7,007 results on '"Teikyo University School of Medicine"'
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2. Efficacy of Automated Supplying Artery Tracking Software Using Multidetector-Row Computed Tomography Images for Emergent Transcatheter Arterial Embolization
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Oba, Hiroshi [Teikyo University School of Medicine, Department of Radiology (Japan)]
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- 2018
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3. Association of bezafibrate with transplant-free survival in patients with primary biliary cholangitis
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Kosuke Matsumoto, Bettina E. Hansen, Hajime Takikawa, Toshiaki Nakano, Olivier Chazouillères, Atsushi Tanaka, Fabrice Carrat, Junko Hirohara, Christophe Corpechot, Teikyo University School of Medicine, Kansai Medical University, Centre de Recherche Saint-Antoine (CRSA), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Centre de Référence des Maladies Rares - Maladies Inflammatoires des Voies Biliaires et Service d’Hépatologie [CHU Saint-Antoine], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), University of Toronto, Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Service de santé publique [CHU Saint-Antoine], and HAL-SU, Gestionnaire more...
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Adult ,Male ,medicine.medical_specialty ,medicine.medical_treatment ,Liver transplantation ,Lower risk ,Gastroenterology ,Cohort Studies ,Japan ,Internal medicine ,medicine ,Humans ,Proportional Hazards Models ,Retrospective Studies ,[SDV.MHEP] Life Sciences [q-bio]/Human health and pathology ,Hepatology ,Liver Cirrhosis, Biliary ,business.industry ,Hazard ratio ,Retrospective cohort study ,Middle Aged ,Prognosis ,Ursodeoxycholic acid ,Transplantation ,Treatment Outcome ,Cohort ,Number needed to treat ,Female ,Bezafibrate ,business ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology ,medicine.drug - Abstract
A beneficial effect of bezafibrate (BZF) on symptoms and biochemical features of primary biliary cholangitis (PBC) has been reported in patients with an incomplete response to ursodeoxycholic acid (UDCA), but long-term effects on survival remain unknown. In Japan, BZF has been used as a de facto second-line therapy for PBC since 2000. Herein, we compared the survival rates between patients treated with and those without BZF in a large nationwide Japanese PBC cohort.All consecutively registered patients of this cohort who started UDCA therapy from 2000 onwards and had a follow-up ≥1 year were included. Association between BZF exposure and mortality or need for liver transplantation (LT) was assessed using time-dependent, multivariable-and propensity score-adjusted Cox proportional hazards models. Clinical benefit was quantified using the number needed to treat (NNT).Of 3,908 eligible patients, 3,162 (81%) received UDCA only and 746 (19%) UDCA and BZF over 17,360 and 3,932 patient-years, respectively. During follow-up, 183 deaths (89 liver-related) and 21 LT were registered. Exposure to combination therapy was associated with a significant decrease in all-cause and liver-related mortality or need for LT (adjusted hazard ratios: 0.3253, 95% CI 0.1936-0.5466 and 0.2748, 95% CI 0.1336-0.5655, respectively; p0.001 for both). This association was consistent across various risk groups at baseline. The NNTs with combination therapy to prevent 1 additional death or LT over 5, 10, and 15 years were 29 (95% CI 22-46), 14 (10-22), and 8 (6-15), respectively.In a large retrospective cohort study of treatment effects in patients with PBC, the addition of BZF to UDCA was associated with improved prognosis.The long-term efficacy of bezafibrate (BZF) on liver transplantation (LT) - free survival in patients with PBC and an incomplete response to ursodeoxycholic acid (UDCA) remains to be determined. In this Japanese nationwide retrospective cohort study, the use of UDCA-BZF combination therapy, compared to UDCA alone, was associated with a lower risk of all-cause and liver-related mortality or need for LT. These results indicate that BZF is so far the only drug in PBC to have demonstrated efficacy in improving symptoms, biochemical markers, and long-term outcomes. more...
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- 2021
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4. Histone deacetylase inhibitor trichostatin A enhances myogenesis by coordinating muscle regulatory factors and myogenic repressors
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Matsumura, Kiichiro [Department of Neurology, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8605 (Japan)]
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- 2011
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5. Negative regulation of parathyroid hormone-related protein expression by steroid hormones
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Okazaki, Tomoki [Department of Biochemistry, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8605 (Japan)]
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- 2011
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6. Acute myelogenous leukemia cells with the MLL-ELL translocation convert morphologically and functionally into adherent myofibroblasts
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Shirafuji, Naoki [Department of Hematology/Oncology, Teikyo University School of Medicine, 2-11-1, Kaga, Itabashi-ku, Tokyo 173-8606 (Japan)]
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- 2010
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7. Diagnostic procedures & practices in drug allergy/hypersensitivity: a survey of 13 Asian countries
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Wen-Hung Chung, Min-Moon Tang, Jiu Yao Wang, Amir Hamzah Abdul Latiff, Luo Zhang, Iris Rengganis, Ticha Rerkpattanapipat, Philip H. Li, Bernard Yu-Hor Thong, Mizuho Nagao, Jie Shen Fok, Pascal Demoly, Masao Yamaguchi, Ruby Pawankar, Francis Thien, Yi-Giien Tsai, Wasu Kamchaisatian, Hye Ryun Kang, James Yun, Mariana Castells, Ting Fan Leung, Takao Fujisawa, Yoon-Seok Chang, Joo-Yoon Ho, Byung Keun Kim, Michaela Lucas, Hospital Kuala Lumpur, Box Hill Hospital, Monash University [Melbourne], Tan Tock Seng Hospital [Singapore, Singapore], The University of Sydney, Nepean Hospital, Queen Mary Hospital, Queen mary Hospital, The University of Hong Kong (HKU), Seoul National University [Seoul] (SNU), Seoul National University Hospital, Teikyo University School of Medicine, Sir Charles Gairdner Hospital, The University of Western Australia (UWA), Seoul National University Bundang Hospital (SNUBH), Korea University Anam Hospital [Seoul], Mie National Hospital [Tsu], Universitas Indonesia (UI ), Cipto Mangunkusumo Hospital [Jakarta], Kaohsiung Medical University, Chang Gung Memorial Hospital [Taipei] (CGMH), Chang Gung University, Ramathibodi Hospital [Bangkok, Thailand], Mahidol University [Bangkok], Samitivej Children's Hospital [Bangkok], The Chinese University of Hong Kong [Hong Kong], Hanyang University, Beijing Tongren Hospital, Capital University of Medical Sciences [Beijing] (CUMS), Pantai Hospital [Kuala Lumpur], Brigham & Women’s Hospital [Boston] (BWH), Harvard Medical School [Boston] (HMS), Département pneumologie et addictologie [Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Arnaud de Villeneuve, Epidemiology of Allergic and Respiratory Diseases Department [Paris] (EPAR), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Université de Montpellier (UM), National Cheng Kung University Hospital [Tainan], Nippon Medical School [Tokyo, Japon], Tan Tock Seng Hospital, Epidemiology of Allergic and Respiratory Diseases Department [iPlesp] (EPAR), and Herrada, Anthony more...
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Allergy ,medicine.medical_specialty ,Provocation test ,Drug allergy ,Dermatology ,Penicillins ,03 medical and health sciences ,0302 clinical medicine ,Abacavir ,Pharmacogenetics, Skin tests ,medicine ,Immunology and Allergy ,030212 general & internal medicine ,Medical prescription ,[SDV.IMM.ALL]Life Sciences [q-bio]/Immunology/Allergology ,Anaphylaxis ,Asthma ,business.industry ,Contrast media ,COVID-19 ,medicine.disease ,3. Good health ,Coronavirus ,030228 respiratory system ,Pharmacogenetics ,Original Article ,business ,Skin tests ,[SDV.IMM.ALL] Life Sciences [q-bio]/Immunology/Allergology ,medicine.drug - Abstract
International audience; Background: The issues and challenges in the diagnosis of drug allergy/hypersensitivity among children and adults in Asia are likely to be different from non-Asian countries.Objective: To study the diagnostic modalities used in the evaluation and management of drug allergy/drug hypersensitivity reactions (DHRs) among member societies of the Asia Pacific Association of Allergy, Asthma and Clinical Immunology (APAAACI).Methods: A questionnaire comprising 41 questions was circulated electronically to member societies and individual members of APAAACI between January 23, 2020 and March 6, 2020.Results: Twenty-six respondents from 15 member societies and 1 individual member responded. European DHR guidelines were most commonly used. Skin prick and intradermal testing was used by 100%, with only 60% having access to commercial penicillin skin test reagents. In vitro-specific IgE tests were used by 75%, and basophil activation test by 56.3% for immediate DHR. Patch tests were used by 75% in contrast to lymphocyte transformation tests by 25% for nonimmediate DHR. Drug provocation tests were used by 68.8%, the most common indication being to exclude hypersensitivity where history/symptoms were not suggestive of drug hypersensitivity/allergy (93.3%). Human leukocyte antigen (HLA) genotype testing was mandatory among 25% respondents before new carbamazepine prescriptions, and 8.3% for allopurinol prescriptions.Conclusions: There was increased use of skin testing for iodinated contrast media hypersensitivity and patch testing for nonimmediate DHR. HLA genotype testing prior to new carbamazepine, allopurinol and abacavir prescriptions remain variable despite strong associations for severe cutaneous adverse reactions with Asian ethnicity. Results of this survey form a useful framework for developing educational and training needs and for improving access to drug allergy diagnostic and treatment modalities across APAAACI member societies. more...
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- 2020
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8. Tyk2 expression and its signaling enhances the invasiveness of prostate cancer cells
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Horie, Shigeo [Department of Urology, Teikyo University School of Medicine, 2-11-1 Kaga, 2chome, Itabashi-ku, Tokyo 173-8605 (Japan)]
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- 2008
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9. Characterization of the protease activity that cleaves the extracellular domain of {beta}-dystroglycan
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Matsumura, Kiichiro [Department of Neurology and Neuroscience, Teikyo University School of Medicine 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8605 (Japan)]
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- 2006
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10. Temporary Percutaneous Aortic Balloon Occlusion to Enhance Fluid Resuscitation Prior to Definitive Embolization of Post-Traumatic Liver Hemorrhage
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Ogata, Hitoshi [Department of Radiology, Teikyo University School of Medicine, Ichihara Hospital, 3426-3 Anesaki, Ichihara, Chiba 299-0111 (Japan)]
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- 2001
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11. Emergent Right Coronary Artery Thrombectomy with a Jet Aspiration Thrombectomy Catheter
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Sasaki, Yasushi [Department of Radiology, Teikyo University School of Medicine, Kaga 2-11-1 Itabashi, Tokyo 1738605 (Japan)]
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- 1999
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12. FMOS near-IR spectroscopy of Herschel-selected galaxies: star formation rates, metallicity and dust attenuation at z similar to 1
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Roseboom, I. G., Bunker, A., Sumiyoshi, M., Wang, L., Dalton, G., Akiyama, M., Bock, J., Bonfield, D., Buat, V., Casey, C., Chapin, E., Clements, D. L., Conley, A., Curtis-Lake, E., Cooray, A., Dunlop, J. S., Farrah, D., Ham, S. J., Ibar, E., Iwamuro, F., Kimura, M., Lewis, I., Macaulay, E., Magdis, G., Maihara, T., Marsden, G., Mauch, T., Moritani, Y., Ohta, K., Oliver, S. J., Page, M. J., Schulz, B., Scott, Douglas, Symeonidis, M., Takato, N., Tamura, N., Totani, T., Yabe, K., Zemcov, M., Heriot-Watt University [Edinburgh] (HWU), Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Space Sciences Laboratory [Berkeley] (SSL), University of California [Berkeley], University of California-University of California, JSR Micro, entreprise, CHANG, Laboratoire de glaciologie et géophysique de l'environnement (LGGE), Observatoire des Sciences de l'Univers de Grenoble (OSUG), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Observatoire des Sciences de l'Univers de Grenoble (OSUG), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Astrophysique de Marseille (LAM), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Aix Marseille Université (AMU)-Centre National d'Études Spatiales [Toulouse] (CNES), Department of Physics and Astronomy [Vancouver], University of British Columbia (UBC), AUTRES, National Center for Atmospheric Research [Boulder] (NCAR), California Institute of Technology (CALTECH), Astronomy Centre, University of Sussex, UK Astronomy Technology Centre (UK ATC), Science and Technology Facilities Council (STFC), Astrophysique Interprétation Modélisation (AIM (UMR_7158 / UMR_E_9005 / UM_112)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), DoCoMo USA Labs, DoCoMo, Division of Respiratory Medicine and Allergology, Teikyo University School of Medicine, Department of Chemistry and Biochemistry, University of California [Los Angeles] (UCLA), Computing and Mathematical Sciences [Pasadena]], Space Science & Technology Department, Rutheford Appleton Laboratory, National Astronomical Observatory of Japan (NAOJ), Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHANG (CHANG), Laboratoire d'étude des transferts en hydrologie et environnement (LTHE), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national des sciences de l'Univers (INSU - CNRS)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national des sciences de l'Univers (INSU - CNRS)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique de Grenoble (INPG)-Centre National de la Recherche Scientifique (CNRS)-Observatoire des Sciences de l'Univers de Grenoble (OSUG), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national des sciences de l'Univers (INSU - CNRS)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national des sciences de l'Univers (INSU - CNRS)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique de Grenoble (INPG)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), University of California [Berkeley] (UC Berkeley), University of California (UC)-University of California (UC), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Astrophysique Interprétation Modélisation (AIM (UMR7158 / UMR_E_9005 / UM_112)), Institut National Polytechnique de Grenoble (INPG)-Centre National de la Recherche Scientifique (CNRS)-Observatoire des Sciences de l'Univers de Grenoble (OSUG), and Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national des sciences de l'Univers (INSU - CNRS)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national des sciences de l'Univers (INSU - CNRS)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS) more...
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Cosmology and Nongalactic Astrophysics (astro-ph.CO) ,[SDU.ASTR]Sciences of the Universe [physics]/Astrophysics [astro-ph] ,FOS: Physical sciences ,Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
We investigate the properties (e.g. star formation rate, dust attentuation, stellar mass and metallicity) of a sample of infrared luminous galaxies at z \sim 1 via near-IR spectroscopy with Subaru-FMOS. Our sample consists of Herschel SPIRE and Spitzer MIPS selected sources in the COSMOS field with photometric redshifts in the range 0.7 < z-phot < 1.8, which have been targeted in 2 pointings (0.5 sq. deg.) with FMOS. We find a modest success rate for emission line detections, with candidate H{\alpha} emission lines detected for 57 of 168 SPIRE sources (34 per cent). By stacking the near-IR spectra we directly measure the mean Balmer decrement for the H{\alpha} and H{\beta} lines, finding a value of = 0.51\pm0.27 for = 10^12 Lsol sources at = 1.36. By comparing star formation rates estimated from the IR and from the dust uncorrected H{\alpha} line we find a strong relationship between dust attenuation and star formation rate. This relation is broadly consistent with that previously seen in star-forming galaxies at z ~ 0.1. Finally, we investigate the metallicity via the N2 ratio, finding that z ~ 1 IR-selected sources are indistinguishable from the local mass-metallicity relation. We also find a strong correlation between dust attentuation and metallicity, with the most metal-rich IR-sources experiencing the largest levels of dust attenuation., Comment: 13 pages, 7 figures, MNRAS accepted more...
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- 2012
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13. DEEP NEAR-INFRARED SPECTROSCOPY OF PASSIVELY EVOLVING GALAXIES AT z greater than or similar to 1.4
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Onodera, M, Renzini, A, Carollo, M, Cappellari, M, Mancini, C, Strazzullo, V, Daddi, E, Arimoto, N, Gobat, R, Yamada, Y, McCracken, HJ, Ilbert, O, Capak, P, Cimatti, A, Giavalisco, M, Koekemoer, AM, Kong, X, Lilly, S, Motohara, K, Ohta, K, Sanders, DB, Scoville, N, Tamura, N, Taniguchi, Y, Institute for Astronomy [Zürich], Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology in Zürich [Zürich] (ETH Zürich), INAF - Osservatorio Astronomico di Padova (OAPD), Istituto Nazionale di Astrofisica (INAF), Sub-department of Astrophysics [Oxford], Department of Physics [Oxford], University of Oxford [Oxford]-University of Oxford [Oxford], Astrophysique Interprétation Modélisation (AIM (UMR_7158 / UMR_E_9005 / UM_112)), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7), National Astronomical Observatory of Japan (NAOJ), Institut d'Astrophysique de Paris (IAP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Astrophysique de Marseille (LAM), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Aix Marseille Université (AMU)-Centre National d'Études Spatiales [Toulouse] (CNES), Spitzer Science Center, California Institute of Technology (CALTECH), Dipartimento di Astronomia, Università di Bologna [Bologna] (UNIBO), Department of Astronomy [Amherst], University of Massachusetts [Amherst] (UMass Amherst), University of Massachusetts System (UMASS)-University of Massachusetts System (UMASS), Space Telescope Science Institute (STSci), AUTRES, Institute of Astronomy, The University of Tokyo, Division of Respiratory Medicine and Allergology, Teikyo University School of Medicine, Institute for Astronomy [Honolulu], University of Hawai‘i [Mānoa] (UHM), Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich), University of Oxford-University of Oxford, Astrophysique Interprétation Modélisation (AIM (UMR7158 / UMR_E_9005 / UM_112)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO), The University of Tokyo (UTokyo), Onodera, M, Renzini, A, Carollo, M, Cappellari, M, Mancini, C, Strazzullo, V, Daddi, E, Arimoto, N, Gobat, R, Yamada, Y, Mccracken, Hj, Ilbert, O, Capak, P, Cimatti, A, Giavalisco, M, Koekemoer, Am, Kong, X, Lilly, S, Motohara, K, Ohta, K, Sanders, Db, Scoville, N, Tamura, N, Taniguchi, Y, and Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC) more...
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[SDU.ASTR]Sciences of the Universe [physics]/Astrophysics [astro-ph] ,Astrophysics::Solar and Stellar Astrophysics ,Astrophysics::Cosmology and Extragalactic Astrophysics ,Astrophysics::Galaxy Astrophysics - Abstract
International audience; We present the results of new near-IR spectroscopic observations of passive galaxies at z greater than or similar to 1.4 in a concentration of BzK-selected galaxies in the COSMOS field. The observations have been conducted with Subaru/MOIRCS, and have resulted in absorption lines and/or continuum detection for 18 out of 34 objects. This allows us to measure spectroscopic redshifts for a sample that is almost complete to K-AB = 21. COSMOS photometric redshifts are found in fair agreement overall with the spectroscopic redshifts, with a standard deviation of similar to 0.05; however, similar to 30% of objects have photometric redshifts systematically underestimated by up to similar to 25%. We show that these systematic offsets in photometric redshifts can be removed by using these objects as a training set. All galaxies fall in four distinct redshift spikes at z = 1.43, 1.53, 1.67, and 1.82, with this latter one including seven galaxies. SED fits to broadband fluxes indicate stellar masses in the range of similar to 4-40 x 10(10) M-circle dot and that star formation was quenched similar to 1 Gyr before the cosmoic epoch at which they are observed. the spectra of several individual galaxies have allowed us to measure their H delta(F) indices and the strengths of the 4000 angstrom break, which confirms their identification as passive galaxies, as does a composite spectrum resulting from the co-addition of 17 individual spectra. The effective radii of the galaxies have been measured on the COSMOS HST/ACS i(F814W)-band image, confirming the coexistence at these redshifts of passive galaxies, which are substantially more compact than their local counterparts with others that follow the local effective radius-stellar mass relation. For the galaxy with the best signal-to-noise spectrum we were able to measure a velocity dispersion of 270 +/- 105 km s(-1) (error bar including systematic errors), indicating that this galaxy lies closely on the virial relation given its stellar mass and effective radius. more...
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- 2012
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14. Severe Chronic Allergic (and related) Diseases: a uniform approach- a MeDALL- GA(2)LEN-ARIA Position Paper
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WHO Collaborating Center for Asthma, Rhinitis, Bousquet, J, Anto, Jm, Demoly, P, Schünemann, Hj, Togias, A, Akdis, M, Auffray, C, Bachert, C, Bieber, T, Bousquet, Pj, Carlsen, Kh, Casale, Tb, Cruz, Aa, Keil, T, Lodrup Carlsen KC, Maurer, M, Ohta, K, Papadopoulos, Ng, Roman Rodriguez, M, Samolinski, B, Agache, I, Andrianarisoa, A, Ang, Cs, Annesi Maesano, I, Ballester, F, Baena Cagnani CE, Basagaña, X, Bateman, Ed, Bel, Eh, Bedbrook, A, Beghe', Bianca, Beji, M, Ben Kheder, A, Benet, M, Bennoor, Ks, Bergmann, Kc, Berrissoul, F, Bindslev Jensen, C, Bleecker, Er, Bonini, S, Boner, Al, Boulet, Lp, Brightling, Ce, Brozek, Jl, Bush, A, Busse, Ww, Camargos, Pa, Canonica, Gw, Carr, W, Cesario, A, Chen, Yz, Chiriac, Am, Costa, Dj, Cox, L, Custovic, A, Dahl, R, Darsow, U, Didi, T, Dolen, Wk, Douagui, H, Dubakiene, R, El Meziane, A, Fonseca, Ja, Fokkens, Wj, Fthenou, E, Gamkrelidze, A, Garcia Aymerich, J, Gerth van Wijk, R, Gimeno Santos, E, Guerra, S, Haahtela, T, Haddad, H, Hellings, Pw, Hellquist Dahl, B, Hohmann, C, Howarth, P, Hourihane, Jo, Humbert, M, Jacquemin, B, Just, J, Kalayci, O, Kaliner, Ma, Kauffmann, F, Kerkhof, M, Khayat, G, Koffi N'Goran, B, Kogevinas, M, Koppelman, Gh, Kowalski, Ml, Kull, I, Kuna, P, Larenas, D, Lavi, I, Le, Lt, Lieberman, P, Lipworth, B, Mahboub, B, Makela, Mj, Martin, F, Martinez, Fd, Marshall, Gd, Mazon, A, Melen, E, Meltzer, Eo, Mihaltan, F, Mohammad, Y, Mohammadi, A, Momas, I, Morais Almeida, M, Mullol, J, Muraro, A, Naclerio, R, Nafti, S, Namazova Baranova, L, Nawijn, Mc, Nyembue, Td, Oddie, S, O'Hehir, Re, Okamoto, Y, Orru, Mp, Ozdemir, C, Ouedraogo, Gs, Palkonen, S, Panzner, P, Passalacqua, G, Pawankar, R, Pigearias, B, Pin, I, Pinart, M, Pison, C, Popov, Ta, Porta, D, Postma, Ds, Price, D, Rabe, Kf, Ratomaharo, J, Reitamo, S, Rezagui, D, Ring, J, Roberts, R, Roca, J, Rogala, B, Romano, A, Rosado Pinto, J, Ryan, D, Sanchez Borges, M, Scadding, Gk, Sheikh, A, Simons, Fe, Siroux, V, Schmid Grendelmeier PD, Smit, Ha, Sooronbaev, T, Stein, Rt, Sterk, Pj, Sunyer, J, Terreehorst, I, Toskala, E, Tremblay, Y, Valenta, R, Valeyre, D, Vandenplas, O, van Weel, C, Vassilaki, M, Varraso, R, Viegi, G, Wang, Dy, Wickman, M, Williams, D, Wöhrl, S, Wright, J, Yorgancioglu, A, Yusuf, Om, Zar, Hj, Zernotti, Me, Zidarn, M, Zhong, N, Zuberbier, T., Beghe', B., Fthenou, E., Boudier, Anne, Hôpital Arnaud de Villeneuve [CHRU Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), IMIM-Hospital del Mar, Generalitat de Catalunya, Center for Research in Environmental Epidemiology (CREAL), Universitat Pompeu Fabra [Barcelona] (UPF)-Catalunya ministerio de salud, CIBER Epidemiologia y Salud Publica, CIBER de Epidemiología y Salud Pública (CIBERESP), Universitat Pompeu Fabra [Barcelona] (UPF), WHO Collaborating Center for Asthma and Rhinitis, Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Pharmacoepidemiologie et évaluation de l'impact des produits de santé sur les populations, Université Bordeaux Segalen - Bordeaux 2-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Clinical Epidemiology and Biostatistics and Medicine, McMaster University [Hamilton, Ontario], National Institute of Allergy and Infectious Diseases [Bethesda] (NIAID-NIH), National Institutes of Health [Bethesda] (NIH), Swiss Institute of Allergy and Asthma Research (SIAF), Universität Zürich [Zürich] = University of Zurich (UZH), Génomique fonctionnelle et biologie systémique pour la santé, Institut des Sciences Biologiques du CNRS, Upper Airway Research Laboratory (URL), Ghent University Hospital, Department of Dermatology and Allergy, VU University Medical Center [Amsterdam], Department of Paediatrics, University of Oslo (UiO)-Oslo University Hospital [Oslo], Division of Allergy and Immunology, Department of Medicine, Creighton University, ProAR - FMB, Federal University of Bahia School of Medicine, Epidemiology and Health Economics, Instittute of Social Health-Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Department of Dermatology, Medical School-Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Division of Respiratory Medicine and Allergology, Teikyo University School of Medicine, Allergy Department, 2nd Pediatric Clinic, Son Pisa Primary Care Centre, IB-Salut Balearic Health Service, Department of Prevention of Environmental Hazards and Allergology, Medical University of Warsaw - Poland-Faculté de Pharmacie de Paris, Department of Allergy and Clinical Immunology, Faculty of Medicine-Transylvania University, Public Hospital Medical Service, Ministry of Health [Mozambique], Epidémiologie des maladies infectieuses et modélisation (ESIM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Center for Public Health Research (CSISP), University of Valencia, Respiratory Medicine, Università degli studi di Genova = University of Genoa (UniGe)-School of Specialization, Faculty of Medicine, Catholic University, Health Sciences Faculty, University of Cape Town, Department of Pulmonology, University of Amsterdam [Amsterdam] (UvA)-Academic Medical Centre, Divisions of Human Genetics Infection, Inflammation and Repair, University of Southampton-School of Medicine, Service de Pneumologie Allergologie, Hôpital La Rabta [Tunis], Service de Pneumologie, Hôpital Abderrahmen Mami, National Asthma Centre, National Institute of Diseases of the Chest and Hospital (NIDCH), Pneumologie / Anesthésie - réanimation / Oxygénothérapie, Hôpital AKS Phnom Penh-Hôpital Provincial de Siemreap, Department of Dermatology and Allergy Center, Odense University Hospital, Center for Genomics and Personalized Medicine, Wake Forest University, Institute of Neurobiology and Molecular Medicine, CNR, Rome, Italy and Department of Medicine-University of Naples Federico II = Università degli studi di Napoli Federico II, Università degli studi di Verona = University of Verona (UNIVR), Institut de cardiologie et de pneumologie, Université Laval [Québec] (ULaval)-Centre Hospitalier de Laval (CH Laval), Department of Respiratory Medicine and Thoracic Surgery, University of Leicester-Institute for Lung Health, Department of Paediatric Respiratory Medicine, Imperial College London-Royal Brompton Hospital-National Heart and Lung Institute [UK], Department of Medicine, University of Wisconsin School of Medicine and Public Health, Department of Pediatrics, Universidade Federal de Minas Gerais [Belo Horizonte] (UFMG)-Medical School, Allergy & Respiratory Diseases, Università degli studi di Genova = University of Genoa (UniGe)-Department of Internal Medicine (DIMI), Allergy & Asthma Associates, University of California [Irvine] (UC Irvine), University of California (UC)-University of California (UC), Deputy Scientific Director, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Pisana, Department of Thoracic Surgery, Università cattolica del Sacro Cuore = Catholic University of the Sacred Heart [Roma] (Unicatt), National Cooperative Group of Pediatric Research on Asthma, Asthma Clinic and Education Center of the Capital Institute of Pediatrics, Service des Premiers Soins, Université Montpellier 1 (UM1), Osteopathic College of Medicine, Nova Southeastern University (NSU), Respiratory Research Group, University of Manchester [Manchester]-School of Translational Medicine, Department of Respiratory Diseases, Aarhus University Hospital, Department of Dermatology and Allergy Biederstein, Technische Universität Munchen - Université Technique de Munich [Munich, Allemagne] (TUM), Service de pneumologie, Centre hospitalier de la région d'Annecy, Service de pneumo-allergologie, Centre Hospitalo-Universitaire de Béni-Messous, Allergy Centre, Vilnius University Antakalnis Hospital, Société Marocaine des Maladies Respiratoires, Centre of Respiratory Diseases and Allergy-Centre commercial Nadia, Allergy Division, Hospital S. João-Centre for Research in Health Technologies and Information Systems (CINTESIS)-Biostatistics and Medical Informatics Department-Porto University Medical School, Department of Otorhinolaryngology, Academic Medical Center - Academisch Medisch Centrum [Amsterdam] (AMC), University of Amsterdam [Amsterdam] (UvA)-University of Amsterdam [Amsterdam] (UvA), Department of Social Medicine, University of Crete [Heraklion] (UOC)-Faculty of Medicine, Health Care, Minister Of Labour-Ministry of Labor, Health and Social Affairs, Section of Allergology, Erasmus Medical Centre, Epidemiology and Biostatistics Division, University of Arizona-Associate Research Scientist, Respiratory Sciences-Arizona Respiratory Center, Helsinki University Hospital-Skin and Allergy Hospital, Centre Hospitalier de Bigorre [Tarbes]-Association Franco-Libanaise de Pneumologie (AFLP), Department of Otorhinolaryngology, Head, and Neck Surgery, University Hospital Leuven, Engineering and the Environment, University of Southampton, Paediatrics and Child Health, University College Cork (UCC), Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-AP-HP - Hôpital Antoine Béclère [Clamart], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre de l'Asthme et des Allergies [CHU Trousseau], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Pediatric Allergy and Asthma Unit, Ihsan Dogramaci Children's Hospital-Hacettepe University School of Medicine, Institute for Asthma and Allergy, George Washington University Medical School, Department of Epidemiology, University of Groningen [Groningen]-University Medical Center Groningen [Groningen] (UMCG)-Groningen Research Institute for Asthma and COPD (GRIAC), Université Saint-Joseph de Beyrouth (USJ)-Faculté de Médecine-Hôtel-Dieu de France, Service des Maladies Respiratoires, CHU de Cocody-UFR des Sciences Médicales, Pediatric Pulmonology, Allergology & Epidemiology, University of Groningen [Groningen]-University Medical Center Groningen [Groningen] (UMCG)-Beatrix Children's Hospital-Groningen Research Institute for Asthma and COPD, Department of Clinical Immunology and Allergy, Medical University of Łódź (MUL)-Faculty ot Medicine, Centre for Allergy Research, Karolinska Institutet [Stockholm], Department of Clinical Science and Education, Division of Internal Medicine, Asthma and Allergy, Medical University of Łódź (MUL)-Barlicki University Hospital, Hospital Medica Sur, Physiology Department, University of Medicine and Pharmacy, Division of Allergy Immunology, Department of Medicine-The University of Tennessee Health Science Center [Memphis] (UTHSC), university of dundee asthma - allergic rhinitis - COPD - beta-2-adrenoceptor, University of Dundee, Pulmonary and allergy unit, American University of Sharjah-Rashid Hospital-Dubai Health Authority (DHA), Association Franco-Vietnamienne de Pneumologie (AFVP), Centre Hospitalier de Compiègne (CHC), Arizona Respiratory Center, Department of Medicine, Clinical Immunology and Allergy, University of Mississippi Medical Center (UMMC), Institute of Environmental Medicine, Karolinska Institutet [Stockholm]-Karolinska University Hospital [Stockholm]-Astrid Lindgren Children's Hospital, Allergy & Asthma Medical Group & Research Center, University of California [San Diego] (UC San Diego), Pneumology Department, Marius Nasta Institute of Pneumology, Department of Internal Medicine, Tishreen University School of Medicine, Association Franco-Marocaine de Pathologie Thoracique (AFMAPATH), Collège National des Pneumologues Marocains, Epidémiologie Environnementale : Impact Sanitaire des Pollutions (EA 4064), Université Paris Descartes - Paris 5 (UPD5), Immunoallergy Department, Hospital CUF Descobertas, Rhinology Unit & Smell Clinic, Universitat de Barcelona (UB)-Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)-Department of Medicine-Hospital Clinic-ENT Department, Allergy Unit, Università degli Studi di Padova = University of Padua (Unipd)-Department of Paediatrics, Section of Otolaryngology-Head & Neck Surgery (OHNS), University of Chicago, Clinique des maladies respiratoires, centre hospitalo-universitaire Mustapha Pacha d'Alger (CHUMA), Scientific Center for Children's Health, Russian Academy of Medical Sciences (RAMS), Laboratory of Allergology and Pulmonary Diseases, University of Groningen [Groningen]-University Medical Center Groningen [Groningen] (UMCG)-Department of Pathology and Medical Biology-GRIAC Research Institute, ENT Department, University of Kinshasa (UNIKIN), Bradford Neonatology, Bradford Teaching Hospitals NHS Foundation Trust-Bradford Institute for Health Research, Department of Allergy, Immunology and Respiratory Medicine, Alfred Hospital-Monash University Building, AMREP, Chiba University Hospital, Asthme Rhinite allergique, Pharmacie, Division of Pediatric Allergy and Immunology, marmara university, Pédiatrie, Centre Hospitalier National Pédiatrique Charles de Gaulle (CHNP-CDG), European Federation of Allergy (EFA), Airways Diseases Patients' Associations, Department of Allergology and Clinical Immunology, Charles University [Prague] (CU)-Medical Faculty in Pilsen, Immunopharmacology, Nippon Medical School-Medical Research Council Clinical, Laboratoire du Sommeil et de l'Effort, Société de Pneumologie de Langue Française (SPLF)-Clinique St George, Institut d'oncologie/développement Albert Bonniot de Grenoble (INSERM U823), Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble-EFS-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire de bioénergétique fondamentale et appliquée (LBFA), Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM), Clinic of Allergy and Asthma, Medical University Sofia-Alexander's University Hospital, Regional Health Service - Lazio, Primary Care Respiratory Medicine, University of Aberdeen-Department of General Practice and Primary Care-General Practice Airways Group (GPIAG), Department of Pulmonary Medicine, Leiden University Medical Center (LUMC), Pneumalgia, Centre Hospitalier Regional-Espace Francophone de Pneumologie (EFP)-Société de Pneumologie de l'Océan Indien (SPOI), Association Franco-Algérienne de Pneumologie (AFAP), Espace Francophone de pneumologie de la SPLF, Department of Pneumology, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)-Hospital Clínic de Barcelona-Institut Clínic del Tórax (ICT)-CIBER de Enfermedades Respiratorias (CIBERES)-University of Barcelona, Allergology and Clinical Immunology, Medical University of Silesia (SUM)-Chair and Clinical Department of Internal Diseases, UCSC-Allergy Unit, Complesso Integrato Columbus-Department of Internal Medicine and Geriatrics, Hospital da Luz, Medical Centre, Woodbrook Medical Centre, Research Fellow, University of Aberdeen-Department of General Practice, Centro Médico Docente La Trinidad, Department of Pharmacology, University College of London [London] (UCL)-The Royal National Throat, Nose and Ear Hospital, Primary Care Research & Development, University of Edinburgh-Centre for Population Health Sciences, Section of Allergy & Clinical Immunology, University of Manitoba [Winnipeg]-Department of Pediatrics & Child Health, Allergy Unit - Department of Dermatology, Julius Center for Health Sciences and Primary Care, University Medical Center [Utrecht], National Centre of Cardiology and Internal Medicine, Ministry of Health Kyrgyz Republic, School of Medicine, Pontifícia Universidade Católica, Department of ENT and Pediatrics, Finnish Institute of Occupational Health, Department of Obstetrics and Gynaecology, Université Laval [Québec] (ULaval)-Faculty of Medicine, Christian Doppler Laboratory for Allergy Research, Medizinische Universität Wien = Medical University of Vienna-Division of Immunopathology-Department of Pathophysiology and Allergy Research-Center for Pathophysiology, Infectiology and Immunology, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Avicenne [AP-HP], Department of Chest Medicine, Mont-Godinne Hospital-Catholic University of Louvain de Mont-Godinne, Department of Primary and Community Care, Radboud University Medical Center [Nijmegen], Epidemiology Unit, National Research Council (CNR)-Institute of Biomedicine and Molecular Immunology (IBIM), Pulmonary Environmental Epidemiology Unit, CNR Institute of Clinical Physiology, Department of Otolaryngology, National University of Singapore (NUS)-Yong Loo Lin School of Medicine, Karolinska Institutet [Stockholm]-Sachs' Children's Hospital, GLP Analytical Facility, School of Pharmacy, Department of Dermatology Division of Immunology, Allergy and Infectious Diseases (DIAID), Medical University of Vienna (MUW), Celal Bayar University School of Medicine, Allergy and Asthma Clinics, The Allergy and Asthma Institute, Department of Paediatrics and Child Health, Respiratory and Allergic Diseases, University Clinic of Respiratory and Allergic Diseases Golnik, State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Diseases-Guangzhou Medical College, Secretary General of the Global Allergy and Asthma European Network (GA2LEN), Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], In collaboration with the WHO Collaborating Center for Asthma and Rhinitis, University of Genoa (UNIGE)-School of Specialization, CNR, Rome, Italy and Department of Medicine-University of Naples Federico II, University of Verona (UNIVR), Medical School-Federal University of Minas Gerais, University of Genoa (UNIGE)-Department of Internal Medicine (DIMI), University of California [Irvine] (UCI), University of California-University of California, Catholic University Rome, University of Amsterdam [Amsterdam] (UvA)-Academic Medical Center - Academisch Medisch Centrum [Amsterdam] (AMC), University of Amsterdam [Amsterdam] (UvA), Centre Hospitalier de Bigorre (Tarbes)-Association Franco-Libanaise de Pneumologie (AFLP), CUF-Descobertas Hospital, Universita degli Studi di Padova-Department of Paediatrics, Medical Faculty in Pilsen-Charles University in Prague - the First Faculty of Medicine, Centro Medico-Docente La Trinidad, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Charité - UniversitätsMedizin = Charité - University Hospital [Berlin]-Instittute of Social Health, Department of Internal Medicine (DIMI)-University of Genoa (UNIGE), Medical University of Silesia-Chair and Clinical Department of Internal Diseases, Dermatology, Internal Medicine, Immunology, Hôpital Arnaud de Villeneuve, Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ), Centre de recherche en épidémiologie et santé des populations ( CESP ), Université de Versailles Saint-Quentin-en-Yvelines ( UVSQ ) -Université Paris-Sud - Paris 11 ( UP11 ) -Assistance publique - Hôpitaux de Paris (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Center for Research in Environmental Epidemiology ( CREAL ), Universitat Pompeu Fabra [Barcelona]-Catalunya ministerio de salud, Universitat Pompeu Fabra [Barcelona], WHO(OMS), Université Bordeaux Segalen - Bordeaux 2-Université de Rouen Normandie ( UNIROUEN ), Normandie Université ( NU ) -Normandie Université ( NU ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), National Institute of Allergy and Infectious Diseases [Bethesda], National Institutes of Health ( NIH ), Swiss Institute of Allergy and Asthma Research ( SIAF ), University of Zürich [Zürich] ( UZH ), Upper Airway Research Laboratory ( URL ), University Medical Center, University of Oslo ( UiO ) -Oslo University Hospital, Charite-Universitatsmedizin Berlin [Berlin]-Instittute of Social Health, Medical School-Charité - University Medicine Berlin, Medical University of Warsaw-Faculté de Pharmacie de Paris, Ministry of Health, Epidémiologie des maladies infectieuses et modélisation ( ESIM ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Center for Public Health Research ( CSISP ), University of Genoa ( UNIGE ) -School of Specialization, University of Amsterdam [Amsterdam] ( UvA ) -Academic Medical Centre, University of Southampton [Southampton]-School of Medicine, Hôpital La Rabta [Tunis), Wake Forest University Health Sciences, CNR, Rome, Italy and Department of Medicine-Second University of Naples, Università degli Studi di Verona, Université Laval-l'Hôpital Laval, Imperial College London-Royal Brompton Hospital-National Heart and Lung Institute, University of Genoa ( UNIGE ) -Department of Internal Medicine (DIMI), Southern California Research, Université Montpellier 1 ( UM1 ), Nova Southeastern University, Technische Universität München [München] ( TUM ), Academic Medical Center [Amsterdam] ( AMC ), University of Amsterdam [Amsterdam] ( UvA ) -University of Amsterdam [Amsterdam] ( UvA ), University of Crete ( UOC ) -Faculty of Medicine, University of Southampton [Southampton], UUniversity College Cork - National University of Ireland, Cork (UCC), Université Paris-Sud - Paris 11 ( UP11 ) -Assistance publique - Hôpitaux de Paris (AP-HP)-Hôpital Antoine Béclère, Assistance publique - Hôpitaux de Paris (AP-HP)-CHU Trousseau [APHP], University of Groningen [Groningen]-University Medical Center Groningen-Groningen Research Institute for Asthma and COPD (GRIAC), Université Saint-Joseph de Beyrouth ( USJ ) -Faculté de Médecine-Hôtel-Dieu de France, University of Groningen [Groningen]-University Medical Center Groningen-Beatrix Children's Hospital-Groningen Research Institute for Asthma and COPD, Medical University of Łódź ( MUL ) -Faculty ot Medicine, Medical University of Łódź ( MUL ) -Barlicki University Hospital, Department of Medicine-University of Tennessee College for Medicine, Association Franco-Vietnamienne de Pneumologie ( AFVP ), University of Mississippi Medical Center, University of California [San Diego] ( UC San Diego ), Association Franco-Marocaine de Pathologie Thoracique ( AFMAPATH ), Epidémiologie Environnementale : Impact Sanitaire des Pollutions ( EA 4064 ), Université Paris Descartes - Paris 5 ( UPD5 ), Universitat de Barcelona ( UB ) -Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)-Department of Medicine-Hospital Clinic-ENT Department, Section of Otolaryngology-Head & Neck Surgery ( OHNS ), University of Groningen [Groningen]-University Medical Center Groningen-Department of Pathology and Medical Biology-GRIAC Research Institute, University Hospital of Kinshasa, European Federation of Allergy ( EFA ), Institut d'oncologie/développement Albert Bonniot de Grenoble ( INSERM U823 ), Université Joseph Fourier - Grenoble 1 ( UJF ) -CHU Grenoble-EFS-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Bioenergétique fondamentale et appliquée ( LBFA ), Université Joseph Fourier - Grenoble 1 ( UJF ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Department of General Practice and Primary Care-General Practice Airways Group (GPIAG)-University of Aberdeen, Association Franco-Algérienne de Pneumologie ( AFAP ), Department of General Practice-University of Aberdeen, University College of London [London] ( UCL ) -The Royal National Throat, Nose and Ear Hospital, University Medical Center Utrecht, Faculty of Medicine-Laval University [Québec], Medical University of Vienna-Division of Immunopathology-Department of Pathophysiology and Allergy Research-Center for Pathophysiology, Infectiology and Immunology, Assistance publique - Hôpitaux de Paris (AP-HP)-Hôpital Avicenne, National University of Singapore ( NUS ) -Yong Loo Lin School of Medicine, Department of Dermatology Division of Immunology, Allergy and Infectious Diseases ( DIAID ), Secretary General of the Global Allergy and Asthma European Network ( GA2LEN ), Network of Excellence, Charité - Universitätsmedizin Berlin, CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Bradford Institute for Health Research, Bradford Teaching Hospitals NHS Foundation Trust, Bradford, UK (BIHR), Universiteit Leiden-Universiteit Leiden, and Medizinische Universität Wien = Medical University of Vienna more...
- Subjects
MESH: Asthma ,severity ,MESH: Comorbidity ,Comorbidity ,Severity of Illness Index ,urticaria ,MESH : Chronic Disease ,MESH: Practice Guidelines as Topic ,MESH : Dermatitis, Atopic ,MESH: Urticaria ,risk ,216-31 [Rhinitis ,atopy ,allergen Int Arch Allergy Immunol. 2012,158(3)] ,atopic dermatitis ,MESH : Rhinitis ,MESH: Rhinitis ,[ SDV.SPEE ] Life Sciences [q-bio]/Santé publique et épidémiologie ,Effective primary care and public health [NCEBP 7] ,Immunoglobulin E - Asthma - Rhinitis - Rhinosinusitis - Urticaria - Atopic dermatitis ,MESH : Practice Guidelines as Topic ,Practice Guidelines as Topic ,MESH : Comorbidity ,MESH : Severity of Illness Index ,IgE ,MESH: Sinusitis ,MESH : Urticaria ,MESH: Hypersensitivity ,macromolecular substances ,MESH : Asthma ,Dermatitis, Atopic ,rhinitis ,SDG 3 - Good Health and Well-being ,MESH: Dermatitis, Atopic ,MESH: Severity of Illness Index ,Hypersensitivity ,Humans ,Sinusitis ,rhinosinusitis ,MESH : Hypersensitivity ,MESH: Humans ,MESH: Chronic Disease ,MESH : Humans ,Asthma ,Atopic dermatitis ,Immunoglobulin E ,Rhinitis ,Rhinosinusitis ,Urticaria ,asthma ,allergy ,MESH : Sinusitis ,[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie ,Chronic Disease ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,control - Abstract
Concepts of disease severity, activity, control and responsiveness to treatment are linked but different. Severity refers to the loss of function of the organs induced by the disease process or to the occurrence of severe acute exacerbations. Severity may vary over time and needs regular follow-up. Control is the degree to which therapy goals are currently met. These concepts have evolved over time for asthma in guidelines, task forces or consensus meetings. The aim of this paper is to generalize the approach of the uniform definition of severe asthma presented to WHO for chronic allergic and associated diseases (rhinitis, chronic rhinosinusitis, chronic urticaria and atopic dermatitis) in order to have a uniform definition of severity, control and risk, usable in most situations. It is based on the appropriate diagnosis, availability and accessibility of treatments, treatment responsiveness and associated factors such as comorbidities and risk factors. This uniform definition will allow a better definition of the phenotypes of severe allergic (and related) diseases for clinical practice, research (including epidemiology), public health purposes, education and the discovery of novel therapies. Copyright (C) 2012 S. Karger AG, Basel more...
- Published
- 2012
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15. Pseudogenization of the Slc23a4 gene is necessary for the survival of Xdh-deficient mice.
- Author
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Terada K, Watanabe T, Yasuno N, Ohtsubo T, Shibata S, Ichida K, and Hosoyamada M
- Subjects
- Animals, Mice, Pseudogenes, Mice, Knockout, Hypoxanthine metabolism, Hypoxanthine urine, Male, Longevity genetics, Humans, Female, Disease Models, Animal, Xanthine Dehydrogenase genetics, Xanthine Dehydrogenase metabolism, Xanthine Dehydrogenase deficiency, Xanthine metabolism, Xanthine urine, Hypoxanthine Phosphoribosyltransferase genetics, Hypoxanthine Phosphoribosyltransferase metabolism
- Abstract
In most patients with type 1 xanthinuria caused by mutations in the xanthine dehydrogenase gene (XDH), no clinical complications, except for urinary stones, are observed. In contrast, all Xdh(- / -) mice die due to renal failure before reaching adulthood at 8 weeks of age. Hypoxanthine or xanthine levels become excessive and thus toxic in Xdh(- / -) mice because enhancing the activity of hypoxanthine phosphoribosyl transferase (HPRT), which is an enzyme that uses hypoxanthine as a substrate, slightly increases the life span of these mice. In this study, we targeted the mouse intestinal sodium-dependent nucleobase transporter (SNBT) gene (Slc23a4), which is a pseudogene in humans. Hprt(high)Xdh(- / -)Slc23a4(- / -) mice had a longer life span and reached adulthood. The urinary xanthine excretion of these mice was 20-fold greater than that of patients with type 1 xanthinuria. The urinary hypoxanthine/xanthine ratio of Hprt(high)Xdh(- / -)Slc23a4(- / -) mice was lower than that of patients with type 1 xanthinuria. Hprt(high)Xdh(- / -)Slc23a4(- / -) mice exhibited renal impairment, accompanied by high plasma creatinine levels and anemia. Moreover, female Hprt(high)Xdh(- / -)Slc23a4(- / -) mice produced offspring that did not survive. In conclusion, for the first time, we established that Xdh(- / -) mice survive to adulthood., Competing Interests: Declarations. Competing interests: The authors declare no competing interests., (© 2025. The Author(s).) more...
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- 2025
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16. Featuring the morphology: impossible, inseparable, instable, innumerable and infinite.
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Takeda S
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- 2025
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17. Rspo3-mediated metabolic liver zonation regulates systemic glucose metabolism and body mass in mice.
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Uno K, Uchino T, Suzuki T, Sayama Y, Edo N, Uno-Eder K, Morita K, Ishikawa T, Koizumi M, Honda H, Katagiri H, and Tsukamoto K
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- Animals, Mice, Male, Mice, Inbred C57BL, Thermogenesis genetics, Wnt Signaling Pathway, Body Weight, Adipose Tissue metabolism, Thrombospondins metabolism, Thrombospondins genetics, Liver metabolism, Glucose metabolism, Insulin Resistance, Obesity metabolism, Obesity genetics
- Abstract
The unique architecture of the liver consists of hepatic lobules, dividing the hepatic features of metabolism into 2 distinct zones, namely the pericentral and periportal zones, the spatial characteristics of which are broadly defined as metabolic zonation. R-spondin3 (Rspo3), a bioactive protein promoting the Wnt signaling pathway, regulates metabolic features especially around hepatic central veins. However, the functional impact of hepatic metabolic zonation, regulated by the Rspo3/Wnt signaling pathway, on whole-body metabolism homeostasis remains poorly understood. In this study, we analyze the local functions of Rspo3 in the liver and the remote actions of hepatic Rspo3 on other organs of the body by using murine models. Rspo3 expression analysis shows that Rspo3 expression patterns are spatiotemporally controlled in the murine liver such that it locates in the pericentral zones and converges after feeding, and the dynamics of these processes are disturbed in obesity. We find that viral-mediated induction of Rspo3 in hepatic tissue of obesity improves insulin resistance and prevents body weight gain by restoring attenuated organ insulin sensitivities, reducing adipose tissue enlargement and reversing overstimulated adaptive thermogenesis. Denervation of the hepatic vagus suppresses these remote effects, derived from hepatic Rspo3 induction, toward adipose tissues and skeletal muscle, suggesting that signals are transduced via the neuronal communication consisting of afferent vagal and efferent sympathetic nerves. Furthermore, the non-neuronal inter-organ communication up-regulating muscle lipid utilization is partially responsible for the ameliorations of both fatty liver development and reduced skeletal muscle quality in obesity. In contrast, hepatic Rspo3 suppression through Cre-LoxP-mediated recombination system exacerbates diabetes due to glucose intolerance and insulin resistance, promotes fatty liver development and decreases skeletal muscle quality, resulting in obesity. Taken together, our study results reveal that modulation of hepatic Rspo3 contributes to maintaining systemic glucose metabolism and body composition via a newly identified inter-organ communication mechanism., Competing Interests: The authors have declared that no competing interests exist., (Copyright: © 2025 Uno et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.) more...
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- 2025
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18. Correlation between internal limiting membrane preservation and sub-epiretinal membrane space during epiretinal membrane surgery.
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Horiuchi N, Nagai N, Ui R, Takano SI, Kawakita T, and Imamura Y
- Abstract
Purpose: Internal limiting membrane (ILM) is usually peeled simultaneously with epiretinal membrane (ERM), however, in eyes with glaucoma and ERM, ILM is preserved in order to prevent nerve fiber damage. The aim of this study was to evaluate if a new approach for ERM is effective to keep ILM during surgery., Study Design: Retrospective consecutive case series., Methods: ERM was directly grasped with forceps at the site where the scale of submembrane space imaged in OCT was maximum. After the removal of ERM, ILM was stained with brilliant blue G and the area of remaining ILM was graded with 5 patterns. The relationship between ILM preservation and submembrane space was analyzed with ROC curve., Results: Thirty-three eyes of 33 patients undergoing ERM surgery (14 women, mean age: 69.2 years) were enrolled. There were 3 eyes with stage 1, 11 eyes with stage 2, 18 eyes with stage 3, and 1 eye with stage 4. The mean maximum distance between ERM and ILM was 80.5 ± 36.0 μm before surgery. ILM was preserved after initial membrane peeling in 21 of 33 eyes (63.6%). ERM-ILM distance correlated with ILM grading (Spearman rank coefficient: P = 0.03). ROC curve analysis identified cutoff value of ERM-ILM distance for ILM preservation was 66 μm[AUC (95% CI):0.7143 (0.5192-0.9093)]., Conclusions: Eyes with larger ERM-ILM distance are likely to show preserved ILM during ERM surgery. ERM-ILM distance appears to be a biomarker of ILM preservation during ERM surgery, which would be useful to minimize neuroretinal damage in eyes with glaucoma and related diseases., Competing Interests: Declarations. Conflict of interest: N. Horiuchi, None; N. Nagai, None; R. Ui, None; S. Takano, None; T. Kawakita, None; Y. Imamura, None., (© 2024. Japanese Ophthalmological Society.) more...
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- 2025
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19. Real-world effectiveness of mepolizumab in Japanese asthma patients with diverse backgrounds: Improvements in rhinosinusitis imaging (J-Real-Mepo).
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Nagase H, Kobayashi K, Toma-Hirano M, Suzukawa M, Harada N, Masaki K, Miyata Y, Tsuji M, Terada-Hirashima J, Komatsuzaki K, Sasano H, Mizumura K, Kagoya R, Shimizu Y, Yoshihara S, Kihara N, Miyazaki Y, Koya T, Sugihara N, Ishikawa N, Hojo M, Tagaya E, Tanaka A, Fukunaga K, and Gon Y more...
- Abstract
Background: Although randomized controlled trials (RCT) have demonstrated the efficacy of mepolizumab for asthma, they have excluded certain patient subgroups. To bridge the gap between RCT and real-world practice, the effectiveness of mepolizumab in a diverse population, including those potentially excluded from RCT, was assessed. Its effects on imaging findings and symptoms of chronic rhinosinusitis (CRS) with asthma were also assessed., Methods: This retrospective observational study of patients in Japan (J-Real-Mepo: UMIN000045021) evaluated multiple endpoints and analyzed the relationship between clinical background and treatment outcomes., Results: Mepolizumab significantly reduced exacerbations, improved Asthma Control Test (ACT) scores, and forced expiratory volume in 1 s, and reduced oral corticosteroid (OCS) dose, regardless of patient characteristics, including age, body mass index, smoking history, and comorbidities. Regarding RCT exclusion criteria, 29.4 % of patients had no history of exacerbations. Although 25.4 % of these patients required continuous OCS, the OCS dose was reduced similar to those with a history of exacerbations. Disease control and mepolizumab effectiveness in patients with a smoking history ≥10 pack-years was similar to that of never-smokers. Patients with eosinophil counts <150/μL had lower ACT scores and higher OCS use compared with patients with eosinophilia and comparable effectiveness regarding exacerbation and OCS reduction. Significant improvements in Lund-Mackay scores and CRS symptoms were observed., Conclusions: Mepolizumab effectiveness was demonstrated in a broad range of patients including those with RCT exclusion criteria, who had significant disease or OCS burden. These findings may explain the consistent results between RCT and real-world studies of mepolizumab., Competing Interests: Conflict of interest HN reports grants from GSK and Kyorin and personal fees from AstraZeneca, GSK, Kyorin, Novartis, and Sanofi. Kkob reports personal fees from AstraZeneca and GSK. MS reports grants from AstraZeneca, Daiichi Sankyo, GSK, Kyorin, Kyowa Kirin, Sanofi, and Shionogi, and personal fees from AstraZeneca, GSK, Novartis, and Sanofi, and participated in advisory board for AstraZeneca. NH reports personal fees from AstraZeneca, GSK, Kyorin, Novartis, and Sanofi; and grants from AstraZeneca, Daikin, Sanofi. KMa reports personal fees from AstraZeneca, GSK, Kyorin, Novartis, Sanofi, and Viatris. JTH reports personal fees from GSK. KMi reports personal fees from AstraZeneca, GSK, Boehringer Ingelheim, and Novartis. TK reports personal fees from AstraZeneca, GSK, Sanofi, and Novartis. NS reports personal fees from AstraZeneca, GSK, and Sanofi. NI reports personal fees from AstraZeneca and GSK. MH reports personal fees from AstraZeneca, GSK and Sanofi. ET reports personal fees from Sanofi, AstraZeneca, Kyorin, and GSK. AT reports personal fees from AstraZeneca, GSK and Sanofi. KF reports grants from Boehringer Ingelheim, Taiho, and Sanofi, and personal fees from AstraZeneca, Boehringer Ingelheim, Novartis, GSK, and Sanofi. YG reports grants from AstraZeneca, GSK, and Novartis and personal fees from AstraZeneca, GSK, and Sanofi. The rest of the authors have no conflict of interest., (Copyright © 2025 Japanese Society of Allergology. Published by Elsevier B.V. All rights reserved.) more...
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- 2025
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20. The association between physician sex and patient outcomes: a systematic review and meta-analysis.
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Heybati K, Chang A, Mohamud H, Satkunasivam R, Coburn N, Salles A, Tsugawa Y, Ikesu R, Saka N, Detsky AS, Ko DT, Ross H, Mamas MA, Jerath A, and Wallis CJD
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- Humans, Female, Male, Sex Factors, Patient Readmission statistics & numerical data, Length of Stay statistics & numerical data, Adult, Physicians psychology, Physicians statistics & numerical data, Physicians, Women statistics & numerical data
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Background: Some prior studies have found that patients treated by female physicians may experience better outcomes, as well as lower healthcare costs than those treated by male physicians. Physician-patient sex concordance may also contribute to better patient outcomes. However, other studies have not identified a significant difference. There is a paucity of pooled evidence examining the association of physician sex with clinical outcomes., Methods: This random-effects meta-analysis was conducted according to the PRISMA guidelines and prospectively registered on PROSPERO. MEDLINE and EMBASE were searched from inception to October 4th, 2023, and supplemented by a hand-search of relevant studies. Observational studies enrolling adults (≥ 18 years of age) and assessing the effect of physician sex across surgical and medical specialties were included. The risk of bias was assessed using ROBINS-I. A priori subgroup analysis was conducted based on patient type (surgical versus medical). All-cause mortality was the primary outcome. Secondary outcomes included complications, hospital readmission, and length of stay., Results: Across 35 (n = 13,404,840) observational studies, 20 (n = 8,915,504) assessed the effect of surgeon sex while the remaining 15 (n = 4,489,336) focused on physician sex in medical/anesthesia care. Fifteen studies were rated as having a moderate risk of bias, with 15 as severe, and 5 as critical. Mortality was significantly lower among patients of female versus male physicians (OR 0.95; 95% CI: 0.93 to 0.97; P
Q = 0.13; I2 = 26%), which remained consistent among surgeon and non-surgeon physicians (Pinteraction = 0.60). No significant evidence of publication bias was detected (PEgger = 0.08). There was significantly lower hospital readmission among patients receiving medical/anesthesia care from female physicians (OR 0.97; 95% CI: 0.96 to 0.98). In a qualitative synthesis of 9 studies (n = 7,163,775), patient-physician sex concordance was typically associated with better outcomes, especially among female patients of female physicians., Conclusions: Patients treated by female physicians experienced significantly lower odds of mortality, along with fewer hospital readmissions, versus those with male physicians. Further work is necessary to examine these effects in other care contexts across different countries and understand underlying mechanisms and long-term outcomes to optimize health outcomes for all patients., Review Registration: PROSPERO - CRD42023463577., Competing Interests: Declarations. Ethics approval and consent to participate: Not applicable. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests., (© 2025. The Author(s).) more...- Published
- 2025
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21. Retrospective evaluation of a novel ultrasound-based imaging analysis software for predicting radiofrequency ablation areas.
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Sato M, Tateishi R, Zohar Y, Sato J, Watadani T, Moriyama M, Wake T, Nakagomi R, Kinoshita MN, Nakatsuka T, Minami T, Uchino K, Enooku K, Nakagawa H, Asaoka Y, Yamada R, Even N, Amitai I, Abu Y, Fujishiro M, and Koike K more...
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- Humans, Retrospective Studies, Female, Male, Middle Aged, Aged, Tomography, X-Ray Computed methods, Algorithms, Catheter Ablation methods, Image Processing, Computer-Assisted methods, Liver Neoplasms surgery, Liver Neoplasms diagnostic imaging, Carcinoma, Hepatocellular surgery, Carcinoma, Hepatocellular diagnostic imaging, Software, Ultrasonography methods, Radiofrequency Ablation methods
- Abstract
Objective: This study aimed to introduce and evaluate a novel software-based system, BioTrace, designed for real-time monitoring of thermal ablation tissue damage during image-guided radiofrequency ablation for hepatocellular carcinoma (HCC)., Methods: BioTrace utilizes a proprietary algorithm to analyze the temporo-spatial behavior of thermal gas bubble activity during ablation, as seen in conventional B-mode ultrasound imaging. Its predictive accuracy was assessed by comparing the ablation zones it predicted with those annotated by radiologists using contrast-enhanced computed tomography (CECT) 24 hours post-treatment, considered the gold standard. The study included 20 liver tumors., Results: The median tumor measurement along the major axis was 1.2 cm. The median Dice coefficient, Sensitivity, and Precision between BioTrace and CECT were 0.90, 0.91, and 0.91, respectively. The intraclass correlation showed excellent agreement in volume size between BioTrace and CECT findings (0.98)., Conclusion: BioTrace effectively generates an ablation damage prediction map based on real-time ultrasound imaging, accurately predicting the ablation zone as confirmed by 24-hour post-procedural CECT. This system has the potential to enhance the safety and efficacy of ablation procedures in clinical settings., Competing Interests: This study was funded by TechsoMed Medical Technologies and designed in collaboration with the University of Tokyo and SCREEN Holdings Co., Ltd. RT has received lecture fee from TechsoMed Medical Technologies. RY is an employee of SCREEN Holdings Col, Ltd and a shareholder in the company. RY provided technical support for the BioTrace system. YZ is an employee of TechsoMed Medical Technologies. YZ involved in study design, data analysis, and drafting of the manuscript. NE is an employee of TechsoMed Medical Technologies. NE involved in drafting of the manuscript. IA is an employee of TechsoMed Medical Technologies. IA involved in data analysis. YA is an employee of TechsoMed Medical Technologies and a shareholder in the company. YA involved in study design and drafting of the manuscript. This does not alter our adherence to PLOS ONE policies on sharing data and materials., (Copyright: © 2025 Sato et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.) more...
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- 2025
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22. Restoration of Genetic Code in Macular Mouse Fibroblasts via APOBEC1-Mediated RNA Editing.
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Bhakta S, Kodama H, Mimaki M, and Tsukahara T
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- Animals, Mice, Humans, Copper-Transporting ATPases genetics, Copper-Transporting ATPases metabolism, Mutation, RNA Editing genetics, APOBEC-1 Deaminase genetics, APOBEC-1 Deaminase metabolism, Fibroblasts metabolism
- Abstract
RNA editing is a significant mechanism underlying genetic variation and protein molecule alteration; C-to-U RNA editing, specifically, is important in the regulation of mammalian genetic diversity. The ability to define and limit accesses of enzymatic machinery to avoid the modification of unintended targets is key to the success of RNA editing. Identification of the core component of the apoB RNA editing holoenzyme, APOBEC, and investigation into new candidate genes encoding other elements of the complex could reveal further details regarding APOBEC-mediated mRNA editing. Menkes disease is a recessive X-chromosome-linked hereditary syndrome in humans, caused by defective copper metabolism due to mutations in the ATP7A gene, which encodes a copper transport protein. Here, we generated plasmids encoding the MS2 system and the APOBEC1 deaminase domain and used a guide RNA with flanking MS2 sites to restore mutated Atp7a in fibroblasts from a macular mouse model of Menkes disease withs T>C mutation. Around 35% of the mutated C nucleotide (nt) was restored to U, demonstrating that our RNA editing system is reliable and has potential for therapeutic clinical application. RNA base editing via human RNA-guided cytidine deaminases is a potentially attractive approach for in vivo therapeutic application and provides opportunities for new developments in this field. more...
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- 2025
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23. Optimization of dose-dense methotrexate, vinblastine, doxorubicin, and cisplatin therapy for Japanese patients with urothelial carcinoma.
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Kawai T, Kurokawa Y, Taguchi S, Honda K, Maki K, Ambe Y, Saegusa N, Yamamoto M, Miyakawa J, Tokura Y, Inoue H, Tanaka T, Nara K, Kaneko T, Fujii Y, Kamei J, Kakutani S, Yamada Y, Niimi A, Yamada D, Takada T, Nakagawa T, and Kume H more...
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Background: Dose-dense methotrexate, vinblastine, doxorubicin, and cisplatin (dd-MVAC) regimen has been established as a systemic chemotherapy for patients with urothelial carcinoma. However, it is rarely used in Japan owing to the challenges associated with managing the related adverse events. This study aimed to optimize the dd-MVAC protocol for Japanese patients., Methods: Criteria were developed to adjust the doses of anticancer drugs used in dd-MVAC. In this regimen, the initial cycle of methotrexate and cisplatin was administered at 75% of the full dose. Patients who did not experience significant toxicities during the first cycle subsequently received the full dose starting from the second cycle. Additionally, the doses of methotrexate and cisplatin were adjusted according to the Cockcroft-Gault creatinine clearance. Based on these criteria, patients with urothelial carcinoma underwent dd-MVAC between August 2018 and May 2023, and all patients were scheduled to undergo six cycles., Results: A total of 86 patients received dd-MVAC, with 36, 15, and 35 patients receiving it as neoadjuvant, adjuvant, and salvage chemotherapy, respectively. Fifty-nine patients (68.6%) completed the six scheduled cycles. Grade ≥ 3 toxicities of Common Terminology Criteria for Adverse Events were observed in 76 (88.4%) patients; however, most were manageable. In the neoadjuvant cohort, the pathological complete response rate was 52.2% among patients with clinical N0 lower tract urothelial carcinoma. High levels of alkaline phosphatase at the initiation of treatment were correlated with failure to complete six cycles of dd-MVAC., Conclusion: Adjusting the dd-MVAC regimen based on renal function and significant adverse events may result in a high completion rate of scheduled treatments in Japanese patients with urothelial carcinoma., (© The Author(s) 2025. Published by Oxford University Press.) more...
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- 2025
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24. Initial Findings Concerning the Latest Self-Expandable Evolut FX Valve: A Report Using OCEAN-TAVI Registry Data.
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Yashima F, Yamamoto M, Shirai S, Tada N, Naganuma T, Yamawaki M, Yamanaka F, Mizutani K, Noguchi M, Ueno H, Takagi K, Ohno Y, Izumo M, Nishina H, Suzuyama H, Yamasaki K, Nishioka K, Hachinohe D, Fuku Y, Otsuka T, Asami M, Watanabe Y, and Hayashida K more...
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- Humans, Male, Female, Aged, 80 and over, Aged, Japan epidemiology, Postoperative Complications epidemiology, Propensity Score, Transcatheter Aortic Valve Replacement, Registries, Heart Valve Prosthesis, Aortic Valve Stenosis surgery, Bioprosthesis, Prosthesis Design
- Abstract
Data concerning the clinical effect of the latest-generation self-expandable transcatheter heart valve (Evolut FX) remain limited. We aimed to assess the in-hospital outcomes of 3 bioprosthetic valves (Evolut EPO, PRO+, and FX). We analyzed data from a Japanese multicenter registry involving 634 consecutive patients who underwent transcatheter aortic valve replacement with Evolut FX up until October 2023. Patients who underwent transcatheter aortic valve replacement with Evolut EPO between 2018 and 2020 (n = 1,128), and those with Evolut EPO+ between 2020 and 2023 (n = 1,696) served as the control groups. The exclusion criteria comprised patients on dialysis with a history of infective endocarditis or with insufficient data. Unmatched comparisons among the 3 valves were conducted, followed by a propensity score-matched comparison between Evolut EPO+ and FX. In the unmatched cohort, among the Evolut EPO, PRO+, and FX groups, all vascular complications (7.8% vs 5.2% vs 4.5%, respectively, p <0.01) and new pacemaker implantation rates (11.2% vs 6.1% vs 7.7%, respectively, p <0.01) differed significantly. In the propensity score-matched analysis, the rate of all bleeding events was significantly higher in the Evolut EPO+ group (11.0%) than in the FX group (7.0%) (p = 0.02), whereas all vascular complications (4.6% vs 4.6%, respectively, p = 1.00) and new pacemaker implantation (5.9% vs 7.6%, respectively, p = 0.28) rates were comparable. The incidence of stroke in the FX group was approximately half that of the EP+ group (3.7% vs 1.9%, p = 0.095), without statistical significance. In conclusion, compared with the Evolut EPO+, Evolut FX was associated with a lower incidence of in-hospital bleeding complications and may reduce the incidence of in-hospital stroke., Competing Interests: Declaration of competing interest Dr. Nishioka is a clinical proctor at Edwards Lifesciences. Dr. Izumo is a screening proctor at Edwards Life Sciences. Dr. Ohno, Dr. Yashima, Dr. Asami, and Dr. Nishina are clinical proctors at Medtronic. Dr. Naganuma, Dr. Mizutani, Dr. Ueno, Dr. Fuku, and Dr. Takagi are clinical proctors at Edwards Lifesciences and Medtronic. Dr. Yamamoto, Dr. Shirai, Dr. Tada, Dr. Yamasaki, Dr. Hachinohe, Dr. Watanabe, and Dr. Hayashida are clinical proctors at Edwards Lifesciences, Abbott Medical, and Medtronic. The remaining authors declare no conflict of interest., (Copyright © 2024 Elsevier Inc. All rights reserved.) more...
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- 2025
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25. Advantage of spirometry over oscillometry to detect dupilumab's effect on small airway dysfunction.
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Shirai T, Hirai K, Akamatsu T, Mizumura K, Sasano H, Harada N, Tanaka A, Sagara H, Masaki K, Fukunaga K, Kobayashi K, Nagase H, Miyahara N, Kanehiro A, Kitamura N, Sugihara N, Terada-Hirashima J, Hojo M, Chibana K, Tagaya E, and Gon Y more...
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- 2025
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26. Claudin-3 deficiency inhibits allergic responses in an ovalbumin-induced asthma mouse model.
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Ishii Y, Shiota A, Takao T, Yamamoto N, Ogawa T, Jo A, Shinozaki S, Fukuyama S, Koga T, Ito M, Tanaka H, Tamura A, Tsukita S, Matsumoto K, Okamoto I, and Kan-O K
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- 2025
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27. Significance of Endoscopic Redness of Duodenum in Health Checkup.
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Nakayama A, Kato M, Sakaguchi Y, Takahashi Y, Kodashima S, Fujimoto A, Yamamichi N, Miki K, and Yahagi N
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Background and Aim: It is important for endoscopist to diagnose the lesion redness. In this study, we focused on the redness of duodenal bulb. We objectively analyzed the changes in redness of the duodenal bulb using linked color imaging (LCI) with chromatic indicators., Methods: Seven endoscopists observed the duodenal bulb with white light imaging (WLI) and LCI, and evaluated them by visual analogue scale (VAS) for the degree of redness. The difference in VAS between WLI and LCI was defined as ΔVAS. All images were quantified by the Comission Internationale de l'Eclariage- L * a * b * color space. Values related to color differences (Δ E *, Δ L *, Δ a *, and Δ b *) were calculated from the two images of WLI and LCI. Multiple regression analysis was performed for the factors with the health checkup correlated with ΔVAS and the correlation between ΔVAS and Δ E *, Δ L *, Δ a *, and Δ b * was also examined., Results: The analysis prospectively included 1144 examinees. In multiple regression analysis, it revealed that sex ( β = 0.5847, p < 0.0001) and metabolic syndrome ( β = 0.4138, p = 0.0012) were the factors independently influenced ΔVAS. And only Δ a *, a chromatic index for changes in the degree of redness, showed a statistically and considerably positive correlation with ΔVAS ( r = 0.4529, p < 0.0001)., Conclusion: To evaluate the difference in the degree of redness between WLI and LCI of duodenal bulb in esophagogastroduodenoscopy may help in early detection of metabolic syndrome, which rarely has symptoms., Competing Interests: The authors declare no conflicts of interest., (© 2025 The Author(s). JGH Open published by Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd.) more...
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- 2025
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28. A Case of IgA Nephropathy in a Patient With Sarcoidosis: Confirmation of Glomerular Galactose-Deficient IgA1 Deposition.
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Shimizu Y, Ito D, Arakawa M, Shiozaki Y, Suzuki Y, Ito S, Ohashi N, Fujigaki Y, Shimizu A, Yasuda H, and Misaki T
- Abstract
A 63-year-old Japanese housewife was admitted to our hospital because of hematuria and proteinuria lasting for 3 months. At the age of 59 years, she was diagnosed with neurosarcoidosis at another hospital, and she received oral glucocorticoid therapy for 1 year. Her serum angiotensin-converting enzyme (ACE) and 1, 25-dihydroxyvitamin D levels were elevated. Computed tomography showed lymphadenopathy of the tracheal bifurcation and diffuse nodular shadow in the lungs and liver. Renal biopsy findings were compatible with IgA nephropathy without noncaseating granulomas and glomerular galactose-deficient IgA1 (Gd-IgA1) was stained in mesangial area. Because of clinical suspicion of sarcoidosis, liver biopsy was also performed, which showed inflammation with multiple noncaseating granulomas. The patient was diagnosed with IgA nephropathy coincident with sarcoidosis. After oral administration of prednisolone, mild proteinuria persisted; however, serum creatinine level was normalized, hematuria disappeared, and serum ACE and 1, 25-dihydroxyvitamin D levels returned to normal. Although some patients with sarcoidosis occasionally present with glomerulonephritis, there have been few case reports of sarcoidosis with IgA nephropathy. This was the first case report in which glomerular Gd-IgA1 was identified in a patient with IgA nephropathy and sarcoidosis., Competing Interests: The authors declare no conflicts of interest., (Copyright © 2025 Yoshitaka Shimizu et al. Case Reports in Nephrology published by John Wiley & Sons Ltd.) more...
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- 2025
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29. Assessment of heterogeneity according to hospital or medical experience factors in outcomes of chemotherapy for advanced biliary tract cancer: a post-hoc analysis of JCOG1113.
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Fukushi K, Imaoka H, Ikeda M, Mizusawa J, Morizane C, Okusaka T, Kobayashi S, Sasahira N, Shimizu S, Yamazaki K, Okano N, Miwa H, Hara K, Satoi S, Sano K, Sakai K, Sugimoto R, Nakamura K, Terashima T, Ozaka M, and Ueno M more...
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Background: JCOG1113 is a randomized phase III trial that showed non-inferiority of gemcitabine plus S-1 to gemcitabine plus cisplatin in patients with advanced biliary tract cancer. Assessment of inter-institutional heterogeneity in chemotherapy contributes to confirm generalizability and reliability of the study itself. However, there have been no studies conducted to assess the heterogeneity among participating centers in randomized phase III trials for biliary tract cancer., Methods: The objective of this post-hoc analysis was to assess the inter-institutional heterogeneity in the overall survival and progression-free survival of patients with advanced biliary tract cancer treated with first-line chemotherapy in the JCOG1113 trial. The heterogeneity in the overall survival and progression-free survival was assessed according to three factors: hospital volume, experience in medical oncology and experience in biliary intervention. A total of 300 advanced biliary tract cancer patients were analyzed. There were no statistically significant trends observed between hospital volume, experience in medical oncology, or experience in biliary intervention and overall survival (hospital volume: adjusted trend P value = 0.6796; experience in medical oncology: adjusted trend P value = 0.4092; experience in biliary intervention: adjusted trend P value = 0.6112). Similarly, no statistically significant trends were observed between these factors and progression-free survival (hospital volume: adjusted trend P value = 0.3000; experience in medical oncology: adjusted trend P value = 0.1108; experience in biliary intervention: adjusted trend P value = 0.2898)., Conclusions: This study revealed no inter-institutional heterogeneity in the overall survival and progression-free survival in the JCOG1113 study population of advanced biliary tract cancer patients., (© The Author(s) 2025. Published by Oxford University Press.) more...
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- 2025
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30. Effects of different educational interventions on cervical cancer knowledge and human papillomavirus vaccination uptake among young women in Japan: Preliminary results of a cluster randomized controlled trial.
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Takahashi Y, Sasamori Y, Higuchi R, Kaku A, Kumagai T, Watanabe S, Nishizawa M, Takasaki K, Nishida H, Ichinose T, Hirano M, Miyagawa Y, Hiraike H, Kido K, Ishikawa H, and Nagasaka K
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- Humans, Female, Japan, Young Adult, Adolescent, Adult, Surveys and Questionnaires, Health Education methods, Human Papillomavirus Viruses, Uterine Cervical Neoplasms prevention & control, Papillomavirus Vaccines administration & dosage, Health Knowledge, Attitudes, Practice, Health Literacy, Papillomavirus Infections prevention & control, Vaccination statistics & numerical data
- Abstract
The incidence and mortality rates of cervical cancer are increasing among young Japanese women. In November 2021, the Japanese Ministry of Health, Labour, and Welfare reinstated the active recommendation of the human papillomavirus (HPV) vaccine, after it had been suspended in June 2013 due to reports of adverse reactions. However, vaccine hesitancy is prevalent in the younger generation in Japan. To identify obstacles to vaccine uptake, we conducted a randomized study using different methods to provide educational content to improve health literacy regarding cervical cancer and HPV vaccination among Japanese female students. We surveyed 188 Japanese female students, divided into three groups according to the intervention: no intervention, print-based intervention, and social networking service-based intervention. Twenty questionnaires and the Communicative and Critical Health Literacy scales were used as health literacy scales. Participants' knowledge and health literacy improved regardless of the method of education. In fact, participants acquired proper knowledge when given the opportunity to learn about the importance of the disease and its prevention. Therefore, medical professionals in Japan must provide accurate scientific knowledge regarding routine HPV vaccination and the risk of cervical cancer in young women to improve their health literacy and subsequently increase HPV vaccination rates in Japan, which may lead to cervical cancer elimination. Trial registration number: UMIN000036636., Competing Interests: I have read the journal’s policy and the authors of this manuscript have the following competing interests: This research was funded in part by the Investigator-Initiated Studies Program of Merck Sharp & Dohme Corp. (Kenilworth, NJ, USA) and MSD K.K. (grant number 58246). The opinions expressed in this study are those of the authors and do not necessarily represent those of Merck Sharp & Dohme Corp. or MSD K.K. This does not alter our adherence to PLOS ONE policies on sharing data and materials., (Copyright: © 2025 Takahashi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.) more...
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- 2025
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31. Pitfalls of the E-Ref Procedure: Tie Values and the Proportion of the Abnormal Data.
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Tachiyama K, Kanbayashi T, Kawabata A, Hoshino S, Miyaji Y, Kobayashi S, Maruyama H, and Sonoo M
- Abstract
Introduction: Extrapolated reference values (E-Ref) procedure is a new method for determining the cutoff value without collecting the control data. We tried to apply this method to determine the cutoff value for the distal motor latency of the median nerve (median DML). During this process, we found two pitfalls of the E-Ref method. First, the E-Ref procedure did not correctly work when the DML values measured with 0.1 ms accuracy frequently took on tie values. Second, the result was influenced by the proportion of abnormal values. This study investigated these issues., Methods: Data of the median DML were extracted from our laboratory database. To solve the problem of tie values, we tried a wider post-smoothing window in the original E-Ref method. We also devised a modified method conducting pre-smoothing. To see the effect of the proportion of abnormal data, we simulated many datasets having different proportion of abnormal data., Results: In total, 1016 DML values were identified. False deflections due to tie values were often identified as the E-Ref point using the original methods even using a wider window, resulting in unrealistically low values. Modified method was free from this drawback. For all methods, the E-Ref value increased as the proportion of abnormal values increased., Discussion: The problem of tie values, a pitfall of the E-Ref method, might be solved by pre-smoothing the data. The E-Ref value is influenced by the proportion of the normal data, and datasets containing less than 20% abnormal data may achieve appropriate results., (© 2025 Wiley Periodicals LLC.) more...
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- 2025
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32. High systemic inflammation response index (SIRI) level as a prognostic factor for colorectal cancer patients after curative surgery: a single-center retrospective analysis.
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Hayama T, Ochiai H, Ozawa T, Miyata T, Asako K, Fukushima Y, Kaneko K, Nozawa K, Fujii S, Misawa T, and Fukagawa T
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- Humans, Male, Female, Retrospective Studies, Aged, Middle Aged, Prognosis, Neoplasm Recurrence, Local, Kaplan-Meier Estimate, Risk Factors, Disease-Free Survival, Adult, Aged, 80 and over, Colorectal Neoplasms surgery, Colorectal Neoplasms mortality, Colorectal Neoplasms pathology, Inflammation
- Abstract
The Systemic Inflammation Response Index (SIRI), a marker used to assess systemic inflammation, is associated with lower patient survival rates in various cancer types. Factors contributing to the recurrence of colorectal cancer (CRC) have been examined previously using the preoperative SIRI. Herein, we investigated the association between the preoperative SIRI level and both the recurrence-free survival (RFS) and overall survival (OS) in patients diagnosed with CRC. We retrospectively analyzed the case of 406 patients who underwent curative surgery for Stage I-III CRC at a single institution during 2012- 2017. Based on their SIRI levels, we categorized the patients into a low-SIRI group (≤ 1700) and a high-SIRI group (> 1700). Multivariable analyses revealed that a high-SIRI level was an independent risk factor for 5-year RFS (p = 0.045) and OS (p = 0.048) in CRC patients. A Kaplan-Meier analysis demonstrated significantly poorer 5-year RFS and OS outcomes in the high-SIRI group compared to the low-SIRI group (p = 0.0001, p = 0.017 respectively). These findings suggest that the high-SIRI level is significantly associated with a poorer prognosis in patients diagnosed with CRC., Competing Interests: Declarations. Competing interests: The authors declare no competing interests. Ethics: This study was approved by the Teikyo University Ethics Committee (No. 19-127)., (© 2024. The Author(s).) more...
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- 2025
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33. A machine learning model to predict neurological deterioration after mild traumatic brain injury in older adults.
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Abe D, Inaji M, Hase T, Suehiro E, Shiomi N, Yatsushige H, Hirota S, Hasegawa S, Karibe H, Miyata A, Kawakita K, Haji K, Aihara H, Yokobori S, Maeda T, Onuki T, Oshio K, Komoribayashi N, Suzuki M, and Maehara T more...
- Abstract
Objective: Neurological deterioration after mild traumatic brain injury (TBI) has been recognized as a poor prognostic factor. Early detection of neurological deterioration would allow appropriate monitoring and timely therapeutic interventions to improve patient outcomes. In this study, we developed a machine learning model to predict the occurrence of neurological deterioration after mild TBI using information obtained on admission., Methods: This was a retrospective cohort study of data from the Think FAST registry, a multicenter prospective observational study of elderly TBI patients in Japan. Patients with an admission Glasgow Coma Scale (GCS) score of 12 or below or who underwent surgical treatment immediately upon admission were excluded. Neurological deterioration was defined as a decrease of 2 or more points from a GCS score of 13 or more within 24 h of hospital admission. The model predictive accuracy was judged with the area under the receiver operating characteristic curve (AUROC) and the area under the precision-recall curve (AUPRC), and the Youden index was used to determine the cutoff value., Results: A total of 421 of 721 patients registered in the Think FAST registry between December 2019 and May 2021 were included in our study, among whom 25 demonstrated neurological deterioration. Among several machine learning algorithms, eXtreme Gradient Boosting (XGBoost) demonstrated the highest predictive accuracy in cross-validation, with an AUROC of 0.81 (±0.07) and an AUPRC of 0.33 (±0.08). Through SHapley Additive exPlanations (SHAP) analysis, five important features (D-dimer, fibrinogen, acute subdural hematoma thickness, cerebral contusion size, and systolic blood pressure) were identified and used to construct a better performing model (cross-validation AUROC of 0.84 and AUPRC of 0.34; testing data AUROC of 0.77 and AUPRC of 0.19). At the cutoff value from the Youden index, the model showed a sensitivity, specificity, and positive predictive value of 60, 96, and 38%, respectively. When neurosurgeons attempted to predict neurological deterioration using the same testing data, their values were 20, 94, and 19%, respectively., Conclusion: In this study, our predictive model showed an acceptable performance in detecting neurological deterioration after mild TBI. Further validation through prospective studies is necessary to confirm these results., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2025 Abe, Inaji, Hase, Suehiro, Shiomi, Yatsushige, Hirota, Hasegawa, Karibe, Miyata, Kawakita, Haji, Aihara, Yokobori, Maeda, Onuki, Oshio, Komoribayashi, Suzuki and Maehara.) more...
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- 2025
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34. Modulation of the peak velocities and gains of abduction and adduction saccades according to head position.
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Mino H, Sawamura H, Takahashi K, Hara H, Kudo Y, Yamanaka K, Kaida T, Miyata K, Aihara M, and Johkura K
- Abstract
Purpose: To assess the effects of modifying head position and of static ocular counter-rolling (OCR) on abduction and adduction in saccadic eye movements using a head-mounted video-oculographic device., Study Design: A clinical observational study., Methods: The peak velocities and amplitude gains of visually guided 12° saccades were binocularly measured in 21 healthy volunteers with their heads in the upright vertical (0°) and horizontal (± 90°, bilateral side-lying) postures, and in 6 participants with their head positions bilaterally tilted by 30°. The rotation angles of eyeballs generated via OCR in the bilateral 30° and 90° head positions were evaluated in five participants., Results: Peak velocities and gains were significantly higher with the head in the 0° position compared to ± 90°. The decreases in peak velocities and gains at ± 90° were not affected by the apogeotropic or geotropic directions. Faster peak velocities and greater gains on abduction, rather than adduction, were observed under each test condition. The tendencies toward faster peak velocity and greater gain in the 0° head position rather than bilaterally tilted at 30° were preserved. The absolute rotation angles at ± 90° were larger than those at 30°., Conclusions: Head position affected the peak velocities and gains of both abduction and adduction saccades. The findings suggest that modified force vectors exerted by different eye muscles recruited during OCR play a role. Our research provides valuable insights for assessing eye movements across various head positions., Competing Interests: Declarations. Conflict of interest: H. Mino, None; H. Sawamura, None; K. Takahashi, None; H. Hara, None; Y. Kudo, None; K. Yamanaka, None; T. Kaida, None; K. Miyata, None; M. Aihara, Grants or contracts (Santen, Senju, Kowa, Wakamoto), Consulting fees (Santen, Senju, Kowa, Wakamoto, Otsuka, HOYA, CREWT, Astellas), Payment or honoraria for lectures, presentations, speakers, bureaus, manuscript writing or educational events (Santen, Senju, Kowa, Alcon, Otsuka, HOYA, CREWT, Novartis, Glaukos, TOMEY, IRIDEX, Viatris, ZEISS), Participation on a Data Safety Monitoring Board or Advisory Board (Santen, Senju, Kowa, Wakamoto, Otsuka); K. Johkura, None., (© 2024. The Author(s).) more...
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- 2025
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35. Pregnancy and Postpartum Trends in Self-Measured Blood Pressure and Derived Indices: The BOSHI Study.
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Izumi S, Nishimura M, Iwama N, Tomita H, Hamada H, Obara T, Ishikuro M, Murakami T, Satoh M, Hirose T, Saito M, Ohkubo T, Kuriyama S, Yaegashi N, Hoshi K, Imai Y, and Metoki H
- Subjects
- Humans, Female, Pregnancy, Adult, Prospective Studies, Japan epidemiology, Longitudinal Studies, Heart Rate physiology, Postpartum Period physiology, Blood Pressure physiology, Blood Pressure Determination methods
- Abstract
In this study, we aimed to reveal the trends of self-measured blood pressure (SMBP) and SMBP-derived indices during pregnancy and the postpartum period. The Babies and Their Parents Longitudinal Observation in Suzuki Memorial Hospital in the Intrauterine Period (BOSHI) Study is a prospective cohort study in Japan. Participants were instructed to measure SMBP daily during pregnancy and for 1 month after delivery. Among 237 participants with normotensive blood pressure (BP) during pregnancy and the postpartum period who were analyzed using mixed-effects models for repeated measures, the SMBP was measured, on average, 14.3 times from the day before delivery to 28 days postpartum. The systolic blood pressure (SBP) and diastolic blood pressure (DBP) on the day before delivery were 110.6 ± 1.0 and 68.1 ± 0.8 mmHg (estimate ± standard error). Postpartum BP increased from postpartum Days 3-8 in SBP and from Days 3-22 in DBP, compared to that on the day before delivery. The SBP and DBP were 4.9 and 4.7 mmHg higher on postpartum Days 8 and 7 than the day before pregnancy, respectively. During pregnancy, the pulse rate (PR) showed an inverted U-shaped trend and then sharply increased rapidly until the first postpartum day after delivery. The Shock Index showed a similar trend to that of the PR, decreased from labor until postpartum Day 8, and plateaued thereafter. The double product peaked during labor, remained higher than the prelabor levels for approximately 10 days, and then decreased in the postpartum period., (© 2025 The Author(s). The Journal of Clinical Hypertension published by Wiley Periodicals LLC.) more...
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- 2025
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36. Blood DNA virome associates with autoimmune diseases and COVID-19.
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Sasa N, Kojima S, Koide R, Hasegawa T, Namkoong H, Hirota T, Watanabe R, Nakamura Y, Oguro-Igashira E, Ogawa K, Yata T, Sonehara K, Yamamoto K, Kishikawa T, Sakaue S, Edahiro R, Shirai Y, Maeda Y, Nii T, Chubachi S, Tanaka H, Yabukami H, Suzuki A, Nakajima K, Arase N, Okamoto T, Nishikawa R, Namba S, Naito T, Miyagawa I, Tanaka H, Ueno M, Ishitsuka Y, Furuta J, Kunimoto K, Kajihara I, Fukushima S, Miyachi H, Matsue H, Kamata M, Momose M, Bito T, Nagai H, Ikeda T, Horikawa T, Adachi A, Matsubara T, Ikumi K, Nishida E, Nakagawa I, Yagita-Sakamaki M, Yoshimura M, Ohshima S, Kinoshita M, Ito S, Arai T, Hirose M, Tanino Y, Nikaido T, Ichiwata T, Ohkouchi S, Hirano T, Takada T, Tazawa R, Morimoto K, Takaki M, Konno S, Suzuki M, Tomii K, Nakagawa A, Handa T, Tanizawa K, Ishii H, Ishida M, Kato T, Takeda N, Yokomura K, Matsui T, Uchida A, Inoue H, Imaizumi K, Goto Y, Kida H, Fujisawa T, Suda T, Yamada T, Satake Y, Ibata H, Saigusa M, Shirai T, Hizawa N, Nakata K, Imafuku S, Tada Y, Asano Y, Sato S, Nishigori C, Jinnin M, Ihn H, Asahina A, Saeki H, Kawamura T, Shimada S, Katayama I, Poisner HM, Mack TM, Bick AG, Higasa K, Okuno T, Mochizuki H, Ishii M, Koike R, Kimura A, Noguchi E, Sano S, Inohara H, Fujimoto M, Inoue Y, Yamaguchi E, Ogawa S, Kanai T, Morita A, Matsuda F, Tamari M, Kumanogoh A, Tanaka Y, Ohmura K, Fukunaga K, Imoto S, Miyano S, Parrish NF, and Okada Y more...
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- Humans, Female, Genome-Wide Association Study, Male, Anelloviridae genetics, Lupus Erythematosus, Systemic genetics, Lupus Erythematosus, Systemic virology, Lupus Erythematosus, Systemic blood, Lupus Erythematosus, Systemic immunology, DNA, Viral genetics, DNA, Viral blood, Adult, Middle Aged, Japan, COVID-19 genetics, COVID-19 virology, COVID-19 immunology, COVID-19 blood, Herpesvirus 6, Human genetics, Autoimmune Diseases genetics, Autoimmune Diseases virology, Autoimmune Diseases immunology, SARS-CoV-2 genetics, SARS-CoV-2 immunology, Virome genetics
- Abstract
Aberrant immune responses to viral pathogens contribute to pathogenesis, but our understanding of pathological immune responses caused by viruses within the human virome, especially at a population scale, remains limited. We analyzed whole-genome sequencing datasets of 6,321 Japanese individuals, including patients with autoimmune diseases (psoriasis vulgaris, rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), pulmonary alveolar proteinosis (PAP) or multiple sclerosis) and coronavirus disease 2019 (COVID-19), or healthy controls. We systematically quantified two constituents of the blood DNA virome, endogenous HHV-6 (eHHV-6) and anellovirus. Participants with eHHV-6B had higher risks of SLE and PAP; the former was validated in All of Us. eHHV-6B-positivity and high SLE disease activity index scores had strong correlations. Genome-wide association study and long-read sequencing mapped the integration of the HHV-6B genome to a locus on chromosome 22q. Epitope mapping and single-cell RNA sequencing revealed distinctive immune induction by eHHV-6B in patients with SLE. In addition, high anellovirus load correlated strongly with SLE, RA and COVID-19 status. Our analyses unveil relationships between the human virome and autoimmune and infectious diseases., Competing Interests: Competing interests: The authors declare no competing interests., (© 2025. The Author(s).) more...
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- 2025
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37. Predicting dupilumab effectiveness with Type-2 biomarkers: A real-world study of severe asthma.
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Mizumura K, Gon Y, Harada N, Yamada S, Fukuda A, Ozoe R, Maruoka S, Abe S, Takahashi K, Tanaka A, Sagara H, Akamatsu T, Shirai T, Masaki K, Fukunaga K, Kobayashi K, Nagase H, Miyahara N, Kanehiro A, Kitamura N, Sugihara N, Kumasawa F, Terada-Hirashima J, Hojo M, Chibana K, and Tagaya E more...
- Subjects
- Adult, Aged, Female, Humans, Male, Middle Aged, Anti-Asthmatic Agents therapeutic use, Leukocyte Count, Nitric Oxide metabolism, Prospective Studies, Respiratory Function Tests, Severity of Illness Index, Sputum cytology, Treatment Outcome, Antibodies, Monoclonal, Humanized therapeutic use, Asthma drug therapy, Asthma diagnosis, Asthma blood, Biomarkers, Eosinophils
- Abstract
Background: The therapeutic effectiveness of dupilumab for severe asthma in real-world settings is yet to be prospectively investigated across multiple institutions, and uncertainties persist regarding predictive factors for its effectiveness. We aimed to assess the effectiveness of dupilumab and identify predictors of its effectiveness in real-world settings using two type-2 biomarkers: FeNO concentration and blood eosinophil count., Methods: This prospective multicenter study included 103 patients with severe asthma. Exacerbations and respiratory functions were monitored for 24 weeks. Asthma control was evaluated using the Asthma Control Questionnaire-5. Clinical symptoms and their impact on cough and sputum were assessed using the Cough and Sputum Assessment Questionnaire (CASA-Q). Subgroup analyses of type-2 biomarkers were conducted based on FeNO levels and blood eosinophil counts at baseline., Results: Treatment with dupilumab led to a reduction in exacerbations and enhancement in asthma control, FEV
1 , and CASA-Q scores. FEV1 improvement was correlated with enhancement in the sputum domain of the CASA-Q. Patients exhibiting elevated FeNO levels and blood eosinophil counts demonstrated more significant enhancements in FEV1 . CASA-Q sputum domain scores were significantly higher in the group with elevated eosinophil counts. Regression analysis revealed that FeNO levels and blood eosinophil counts are significant predictors of FEV1 improvement, with blood eosinophil counts also predicting sputum improvement in patients treated with dupilumab., Conclusions: Type-2 biomarkers may act as indicators of improvement in FEV1 and sputum outcomes among patients with severe asthma undergoing dupilumab treatment in real-world settings., (Copyright © 2024 Japanese Society of Allergology. Published by Elsevier B.V. All rights reserved.) more...- Published
- 2025
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38. CORR Insights®: No Difference in 10-year Clinical or Radiographic Outcomes Between Kinematic and Mechanical Alignment in TKA: A Randomized Trial.
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Watanabe Y
- Abstract
Competing Interests: All ICMJE Conflict of Interest Forms for authors and Clinical Orthopaedics and Related Research® editors and board members are on file with the publication and can be viewed on request. more...
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- 2025
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39. Tubo-ovarian abscess caused by Clostridioides difficile after eight months of surgery: Case report and review of extraintestinal abdominal abscess cases.
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Nakayama S, Wakabayashi Y, Yamamoto A, Ichinose T, Takasaki K, Nagasaka K, and Kitazawa T
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- Humans, Female, Adult, Drainage, Metronidazole therapeutic use, Abscess microbiology, Abscess drug therapy, Abscess surgery, Fallopian Tube Diseases microbiology, Fallopian Tube Diseases surgery, Abdominal Abscess microbiology, Abdominal Abscess etiology, Clostridium Infections diagnosis, Clostridium Infections microbiology, Clostridium Infections drug therapy, Ovarian Diseases microbiology, Ovarian Diseases surgery, Clostridioides difficile isolation & purification, Anti-Bacterial Agents therapeutic use
- Abstract
We present a case of tubo-ovarian abscess (TOA) caused by Clostridioides difficile (CD) in a 43-year-old female. Despite lacking a history of sexually transmitted diseases, the patient had undergone paraovarian cystectomy nine months before admission. Transvaginal ultrasonography performed eight months post-surgery revealed left ovarian enlargement, accompanied by subsequent lower abdominal pain and fever exceeding 38 °C. As oral antibiotic treatment was ineffective, the patient was admitted to our hospital. Computed tomography upon admission revealed a massive TOA. Surgical drainage of the abscess was performed, and CD was identified in the culture from the pus. The TOA was treated with a three-month course of metronidazole and oral amoxicillin/clavulanic acid. While CD is commonly associated with colitis, extraintestinal manifestations are exceptionally rare. This case represents the inaugural report of TOA resulting from CD. A literature review on abdominal and pelvic CD abscesses found that patients undergoing surgical drainage had a favorable prognosis. Therefore, surgical intervention plays an important role in the management of CD abscesses., Competing Interests: Declaration of competing interest None., (Copyright © 2024 Japanese Society of Chemotherapy, Japanese Association for Infectious Diseases, and Japanese Society for Infection Prevention and Control. Published by Elsevier Ltd. All rights reserved.) more...
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- 2025
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40. Influence of major hepatectomy on gemcitabine-based chemotherapy for recurrent biliary tract cancer after surgery: a subgroup analysis of JCOG1113.
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Okuno T, Morizane C, Mizusawa J, Yanagimoto H, Kobayashi S, Imaoka H, Terashima T, Kawakami H, Sano Y, Okusaka T, Ikeda M, Ozaka M, Miwa H, Todaka A, Shimizu S, Mizuno N, Sekimoto M, Sano K, Tobimatsu K, Katanuma A, Gotoh K, Yamaguchi H, Ishii H, Furuse J, and Ueno M more...
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- Humans, Male, Female, Middle Aged, Aged, Cisplatin therapeutic use, Cisplatin administration & dosage, Oxonic Acid therapeutic use, Oxonic Acid administration & dosage, Drug Combinations, Adult, Gemcitabine, Deoxycytidine analogs & derivatives, Deoxycytidine therapeutic use, Deoxycytidine administration & dosage, Biliary Tract Neoplasms drug therapy, Biliary Tract Neoplasms surgery, Biliary Tract Neoplasms pathology, Hepatectomy, Neoplasm Recurrence, Local drug therapy, Tegafur therapeutic use, Tegafur administration & dosage, Antineoplastic Combined Chemotherapy Protocols therapeutic use
- Abstract
Background: Major hepatectomy (MH) can increase the risk of adverse events (AEs) owing to impaired drug metabolism due to decreased liver volume and surgical injury. Thus, we performed this subgroup analysis using data from JCOG1113, a phase III trial comparing gemcitabine plus S-1 (GS) and gemcitabine plus cisplatin (GC) in patients with advanced and recurrent biliary tract cancer (BTC), to evaluate the effect of MH on the safety and efficacy of GC and GS regimens in patients with recurrent BTC., Methods: Of the 354 patients with advanced BTC enrolled in JCOG1113, 76 patients with postoperative recurrence (30 in the MH group and 46 in the non-MH group) were analyzed., Results: Grade ≥ 3 platelet count decreased in both arms was more frequent in the MH group than in non-MH group (GC, 0.0 vs. 17.6%; GS, 3.9 vs. 15.4%). However, in the MH group, the white blood cell decreased (GC, 55.0 vs. 38.5%; GS, 23.1 vs. 7.7%) and anemia (GC, 15.0 vs. 11.8%; GS, 23.1 vs. 7.7%) were less common than in the non-MH group. The MH and non-MH groups showed no significant difference in overall survival (OS) in both GC [median OS, 23.0 in MH vs. 16.9 months in non-MH (hazard ratio, 0.857; 95% CI 0.387-1.899)], and GS [median OS, 21.5 vs. 14.9 months (hazard ratio, 0.670; 95% CI 0.310-1.447)] arms., Conclusions: The safety and efficacy of gemcitabine-based chemotherapy were comparable between patients who underwent MH and those who underwent other surgeries., Competing Interests: Declarations. Conflict of interest: C.M. reports research Funding from Eisai, Yakult Honsha, Ono Pharmaceutical, Taiho Pharmaceutical, J-Pharma, AstraZeneca, Merck biopharma, Daiichi Sankyo, Boehringer Ingelheim, and honoraria from Novartis, Yakult Honsha, Teijin Pahrma, Eisai, MSD, AstraZeneka, SERVIER, Boehringer Ingelheim, Taiho. J.M.reports Employment/Leadership position/Advisory role from Phizer and honoraria from Chugai Pharmaceutical, Taiho Pharmaceutical, AstraZeneca. S.K. reports research funding from Bayer, Boston Scientific, Chugai Pharmaceutical, Eisai, Eli Lilly Japan, Takeda, Taiho Pharmaceutical, Yakult Honsha. H.I reports fees for promotional materials from Medico’s Hirata, and honoraria from Boston Scientific, Kaneka Medix, Medico’s Hirata, SB KAWASUMI LABORATORIES, AstraZeneca. H.K. reports grants from BMS K.K., ONO Pharmaceutical, Eli Lilly Japan, MSD K.K., and Daiichi Sankyo, and honoraria from Bristol-Myers Squibb, Eli Lilly Japan, MSD K.K., Ono Pharmaceutical, Chugai Pharmaceutical, Daiichi Sankyo, Merck Biopharma, Takeda Pharmaceutical, Yakult Pharmaceutical Industry, Teijin Pharma, Taiho Pharmaceutical, Otsuka Pharmaceutical, Nippon Kayaku, and GlaxoSmithKline. M.I. reports Research Funding from AstraZeneca, Boehringer Ingelheim GmbH, Eisai, J-pharma, Merk biopharma, Ono Pharmaceutical, Eli Lilly Japan, and honoraria from AstraZeneca, Guardant Health Japan, Incyte, Taiho Pharmaceutical. N.M. reports research funding from Novartis, MSD, Incyte, Ono Pharmaceutical, Seagen, Pfizer, Boehringer Ingelheim, AstraZeneca and honoraria from Yakult Honsha, AstraZeneca, Novartis, FUJIFILM Toyama Chemical, MSD, Taiho Pharmaceutical, Boehringer Ingelheim. F.J. reports Research funding from MSD, J-Pharma, Delta-fly-Phrama, Taiho Pharmaceutical, Eisai, Ono Pharmaceutical, Chugai Pharmaceutical, Daiichi Sankyo, Takeda Pharmaceutical, Yakult Honsha and honoraria from Ono Pharmaceutical, Chugai Pharmaceutical, Eisai, Incyte Biosiciences, Eli Lilly Japan, Fuji Film, AstraZeneca, Yakult Honsha. U.M. reports research funding from Taiho Pharmaceutical, AstraZeneca, MSD, Nihon Servier, Ono Pharmaceutical, Incyte Biosciences Japan GK, Chugai Pharmaceutical, Boehringer Ingelheim GmbH, J-pharma, Eisai, Novartis Pharma K.K, Astellas, J-pharma, Delta-fly-Phrama, Novocure GmbH, and Chiome Bioscience Inc. and honoraria from Taiho Pharmaceutical, AstraZeneca, K.K, Yakult Honsha, MSD K.K, Nihon Servier, Ono Pharmaceutical, Incyte Biosciences Japan GK, Chugai Pharmaceutical, Boehringer Ingelheim GmbH, J-pharma, Daiichi Sankyo, Eisai, Takeda Pharmaceutical, Novartis Pharma K.K., (© 2024. The Author(s) under exclusive licence to Japan Society of Clinical Oncology.) more...
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- 2025
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41. Anti-integrin αvβ6 autoantibody in primary sclerosing cholangitis: a Japanese nationwide study.
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Yasuda M, Shiokawa M, Kuwada T, Nishikawa Y, Nakanishi R, Takimoto I, Chikugo K, Yokode M, Muramoto Y, Matsumoto S, Nakamura T, Ota S, Matsumori T, Kuroda K, Hachiya T, Yamazaki H, Uza N, Kodama Y, Chiba T, Fujisawa T, Komori A, Abe M, Yamaguchi I, Matsuda F, Isayama H, Tanaka A, and Seno H more...
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- Humans, Male, Female, Middle Aged, Adult, Japan, Retrospective Studies, Aged, Young Adult, Case-Control Studies, Inflammatory Bowel Diseases immunology, Inflammatory Bowel Diseases diagnosis, East Asian People, Cholangitis, Sclerosing immunology, Cholangitis, Sclerosing diagnosis, Autoantibodies blood, Autoantibodies immunology, Integrins immunology, Enzyme-Linked Immunosorbent Assay, Biomarkers blood, Sensitivity and Specificity, Antigens, Neoplasm immunology
- Abstract
Background: Although specific biomarkers for primary sclerosing cholangitis (PSC) are required, no such biomarkers have been identified. We previously reported that patients with PSC had anti-integrin αvβ6 autoantibodies at only two hospitals. In this study, we aimed to validate the accuracy of the autoantibodies in diagnosing PSC using the newly developed Anti-integrin αvβ6 enzyme-linked immunosorbent assay (ELISA) Kit, which enables quantitation and comparison of antibodies among different facilities., Methods: Overall, 81 patients with PSC in a Japanese PSC registry recruited from 17 medical centers and hospitals, and 358 controls were enrolled. We retrospectively assessed anti-integrin αvβ6 autoantibodies using the Anti-integrin αvβ6 ELISA Kit and in-house ELISA., Results: Anti-Integrin αvβ6 ELISA Kit and in-house ELISA exhibited a significant correlation (r = 0.97, P < 0.001). Anti-integrin αvβ6 autoantibodies were detected in 67 of 81 (82.7%) patients with PSC and 20 of 358 (5.6%) controls, resulting in a sensitivity of 82.7% and specificity of 94.4% for PSC, using the anti-integrin αvβ6 ELISA Kit. When focusing on the presence or absence of inflammatory bowel disease (IBD), the sensitivities for PSC with ulcerative colitis, Crohn's disease, unclassified-IBD, and without IBD were 97.8% (43/44), 100% (1/1), 80.0% (8/10), and 53.8% (7/13), respectively. Antibody concentrations were significantly higher in PSC patients without IBD than in controls (P < 0.001)., Conclusions: We validated that anti-integrin αvβ6 autoantibodies have high sensitivity and specificity for diagnosing PSC. This study provides further evidence that anti-integrin αvβ6 autoantibodies are a useful biomarker for diagnosing PSC., (© 2024. The Author(s).) more...
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- 2025
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42. Practice guidelines on endoscopic surgery for qualified surgeons by the endoscopic surgical skill qualification system: Spleen.
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Nagao Y, Akahoshi T, Nakata K, Ohtsuka T, Nagakawa Y, Nakamura Y, Misawa T, Hashizume M, and Nakamura M
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- 2025
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43. Risk factors for post-endoscopic retrograde cholangiopancreatography complications in very elderly patients aged 90 years or older-No additional risk.
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Manabe D, Arizumi T, Aoyagi H, Abe K, Kodashima S, Asaoka Y, Yamamoto T, and Tanaka A
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- Humans, Female, Male, Aged, 80 and over, Risk Factors, Aged, Retrospective Studies, Age Factors, Cholangiopancreatography, Endoscopic Retrograde adverse effects, Postoperative Complications epidemiology, Postoperative Complications etiology
- Abstract
Aim: In recent years, the majority of patients eligible for endoscopic retrograde cholangiopancreatography (ERCP) have been aged ≥75 years. We investigated ERCP safety in very elderly patients (aged ≥90 years)., Methods: We included patients aged ≥75 years who underwent ERCP between January 2015 and December 2020. We compared background factors, comorbidities, ERCP indications, complications, and outcomes and identified risk factors for complications using binary logistic regression and inverse probability of treatment weighting with propensity scores., Results: The study included 1344 patients aged ≥75 years (137 and 1207 very elderly and elderly patients, respectively). The very elderly group had more women, less frequent diabetes, fewer antithrombotic medications, more frequent parapapillary diverticulum, less frequent post-cholecystectomy, and worse performance status. No significant differences were observed in the ERCP indications. Experienced endoscopists were likely to perform the procedure, and the procedure time was shorter for the very elderly. Complications occurred in 21 (15%) very elderly patients and 120 (10%) elderly patients, with no significant differences. The very elderly did not have an increased risk of complications but were less likely to be discharged home and had a significantly worse performance status at discharge., Conclusions: ERCP could be safely performed in the very elderly, and age did not increase the risk of complications. Geriatr Gerontol Int 2025; 25: 54-60., (© 2024 Japan Geriatrics Society.) more...
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- 2025
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44. Serum interleukin-10 level is increased and correlated positively with disease severity in patients with dipeptidyl peptidase-4 inhibitor-related bullous pemphigoid.
- Author
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Suzuki S, Kamata M, Uchida H, Shimizu T, Okada Y, Ito M, Watanabe A, Mizukawa I, Egawa S, Chijiwa C, Hiura A, Fukaya S, Hayashi K, Fukuyasu A, Tanaka T, Ishikawa T, and Tada Y
- Subjects
- Humans, Male, Female, Aged, Retrospective Studies, Middle Aged, Aged, 80 and over, Autoantibodies blood, Autoantibodies immunology, Collagen Type XVII, Non-Fibrillar Collagens immunology, Non-Fibrillar Collagens blood, Case-Control Studies, Autoantigens immunology, Interleukin-6 blood, Biomarkers blood, Pemphigoid, Bullous blood, Pemphigoid, Bullous chemically induced, Pemphigoid, Bullous immunology, Pemphigoid, Bullous diagnosis, Dipeptidyl-Peptidase IV Inhibitors adverse effects, Severity of Illness Index, Interleukin-10 blood
- Abstract
Bullous pemphigoid (BP) is an autoimmune subepidermal blistering disease with a linear deposit of autoantibodies at the epidermal basement membrane zone. It was reported that diabetes patients who took a dipeptidyl peptidase-4 inhibitor (DPP4i), an oral antidiabetic drug, had an increased incidence of BP. However, data on DPP4i-related BP are limited. In our study, we measured serum levels of various cytokines using LEGENDplex and assessed correlations of these serum levels with clinical severity and laboratory data. Serum samples obtained from BP patients who visited our hospital from June 2016 to February 2023 were collected in this study. Patients' background, characteristics, and clinical data were retrospectively collected from their charts. Serum samples from 27 patients with DPP4i-unrelated BP, 17 patients with DPP4i-related BP, and 13 healthy controls were analyzed. Patients with DPP4i-related BP had lower score of Bullous Pemphigoid Disease Area Index (BPDAI)-erythema/urticaria, lower number of circulating eosinophils, and lower titer of anti-BP180 antibody than patients with DPP4i-unrelated BP. The serum interleukin (IL)-6 level was significantly higher in patients with DPP4i-related BP than in healthy controls (P = 0.0037). The serum IL-10 level was significantly higher in patients with DPP4i-related BP than in patients with DPP4i-unrelated BP and in healthy controls (P = 0.0006, P = 0.0448), and was positively correlated with the BPDAI-blister/erosions score (r = 0.757, P = 0.001), BPDAI-erythema/urticaria score (r = 0.616, P = 0.013), and BPDAI-total score (r = 0.833, P < 0.001) in patients with DPP4i-related BP. In conclusion, patients with DPP4i-related BP had increased serum levels of IL-6 and IL-10 compared with healthy controls and positive correlations between the serum IL-10 level and BPDAI scores reflecting clinical severity, indicating that the serum IL-10 level is a potential objective biomarker of disease severity in patients with DPP4i-related BP., (© 2024 Japanese Dermatological Association.) more...
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- 2025
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45. Split phenomena in manual muscle testing that are helpful for clinical practice.
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Sonoo M
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- 2025
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46. Antihypertensive combinations: mind the potassium.
- Author
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Shibata S
- Subjects
- Humans, Angiotensin Receptor Antagonists therapeutic use, Angiotensin Receptor Antagonists pharmacology, Drug Therapy, Combination, Mineralocorticoid Receptor Antagonists therapeutic use, Mineralocorticoid Receptor Antagonists pharmacology, Angiotensin-Converting Enzyme Inhibitors therapeutic use, Angiotensin-Converting Enzyme Inhibitors pharmacology, Antihypertensive Agents therapeutic use, Antihypertensive Agents pharmacology, Hypertension drug therapy, Hypertension physiopathology, Potassium
- Abstract
Antihypertensive medications that can affect potassium homeostasis in the body. JGA, juxtaglomerular apparatus; ACEIs, angiotensin converting enzyme inhibitors; ARBs, angiotensin receptor blockers; MR, mineralocorticoid receptor., Competing Interests: Compliance with ethical standards. Conflict of interest: The author received personal fees and/or research funding from AstraZeneca, Bayer, and Daiichi-Sankyo., (© 2024. The Author(s), under exclusive licence to The Japanese Society of Hypertension.) more...
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- 2025
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47. Expert consensus on systemic therapy for plaque psoriasis with limited skin involvement in JAPAN: Results from a DELPHI study.
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Morita A, Okubo Y, Imafuku S, Tada Y, Abe M, Gibson AEJ, Becker F, Bogoeva N, and Ohtsuki M
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- Humans, Japan, Dermatologic Agents administration & dosage, Dermatologic Agents therapeutic use, Severity of Illness Index, Treatment Failure, Patient Selection, Skin pathology, Skin drug effects, Psoriasis drug therapy, Psoriasis diagnosis, Psoriasis therapy, Delphi Technique, Consensus
- Abstract
Our objective was to establish consensus on (1) which patients with plaque psoriasis and limited skin involvement (body surface area [BSA] <10%) are suitable for systemic treatment, and (2) a definition of 'topical therapy failure'. A steering committee refined 13 statements drawn from literature related to the study objectives. An independent panel of 45 clinical experts from Japan indicated their agreement to each statement using a 10-point Likert scale (Round 1; strong consensus, ≥70% of responses = 7-10 and median value ≥8). The steering committee reviewed Round 1 results and refined the statements for Round 2, as necessary. In Round 2, the panel indicated their agreement to each statement using a 3-point scale (strong consensus, ≥70% of responses and median value of 3) and were shown Round 1 responses before voting. Forty-five clinicians participated in Round 1 and 41 of those (91%) participated in Round 2. Consensus was achieved on the criteria of eligibility for systemic treatment among patients with limited skin involvement as disease involvement at special or difficult to treat areas, psoriasis-induced psychological distress, uncontrolled symptoms (e.g., scaling, bleeding, pruritus, insomnia) affecting their social life, psoriatic arthritis, or failure of topical therapy. Consensus on criteria for topical failure were persistent symptoms (e.g., itchiness, pain) and plaques, poor patient satisfaction with treatment, a need to increase medication quantity or application time after treatment with two topicals for 4 weeks; or if the Psoriasis Area Severity Index score of >3 or Physician Global Assessment Score of ≥2 after 8 weeks treatment. Our Delphi panel proposes criteria to help physicians identify patients with psoriasis and limited skin involvement who would benefit from systemic therapy and suggests a definition for topical therapy 'failure' which could indicate a move to systemic treatment is warranted., (© 2024 Japanese Dermatological Association.) more...
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- 2025
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48. Fluoroquinolone resistance and clinical characteristics of acute bacterial prostatitis in Japan: A multicenter study by the Japanese research group for urinary tract infection.
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Matsumoto M, Hamasuna R, Wada K, Sadahira T, Shigemura K, Maeda K, Hiyama Y, Togo Y, Nagasawa S, Yamanaka K, Shigehara K, Kobayashi K, Tsuchiya H, Miyazaki J, Nakagawa T, Ishikawa K, Takahashi S, Fujimoto N, and Yamamoto S more...
- Subjects
- Humans, Male, Japan epidemiology, Retrospective Studies, Aged, Middle Aged, Risk Factors, Adult, Escherichia coli drug effects, Escherichia coli isolation & purification, Aged, 80 and over, Acute Disease, Escherichia coli Infections drug therapy, Escherichia coli Infections microbiology, East Asian People, Prostatitis microbiology, Prostatitis drug therapy, Fluoroquinolones therapeutic use, Anti-Bacterial Agents therapeutic use, Drug Resistance, Bacterial, Urinary Tract Infections drug therapy, Urinary Tract Infections microbiology
- Abstract
Objective: This multicenter study aimed to analyze the risk factors for fluoroquinolone (FQ) resistance and to clarify the clinical characteristics of acute bacterial prostatitis (ABP) in Japan., Methods: A total of 124 patients clinically diagnosed with ABP at 13 medical institutions participating in the Japanese Research Group for Urinary Tract Infection between January and December 2017 were retrospectively reviewed., Results: Of the 124 patients included in this study, 37 were outpatients, and 87 were inpatients. The main underlying medical conditions before the onset of ABP were severe dysuria, urinary retention, transurethral manipulation, indwelling urinary catheter, and transrectal prostate biopsy (TRBx). The main symptoms were fever (≥37.5 °C), prostate tenderness, dysuria, micturition pain, urinary retention, and macrohematuria. Bacteremia was observed in 14 patients. Prostatic abscess was observed in three patients. Escherichia coli was the predominant organism, accounting for 48 % (51/106). FQ-resistant E. coli was detected in 33 % (17/51), and extended-spectrum beta-lactamase-producing E. coli in 12 % (6/51). TRBx (odds ratio [OR] = 48.60, 95 % confidence interval [CI]: 5.49-430.00, p < 0.001) and inpatient status (OR = 29.00, 95 % CI: 1.95-430.00, p = 0.014) were risk factors for the detection of FQ-resistant bacteria., Conclusions: The detection rate of FQ-resistant bacteria was significantly higher with TRBx ABP and inpatient status. These findings have important implications for the management of ABP and antimicrobial treatment, especially for TRBx ABP, which should be considered a separate category., Competing Interests: Declaration of Competing interest The authors declare no conflicts of interest., (Copyright © 2024 Japanese Society of Chemotherapy, Japanese Association for Infectious Diseases, and Japanese Society for Infection Prevention and Control. Published by Elsevier Ltd. All rights reserved.) more...
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- 2025
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49. Digital hypertension, implementation hypertension, and internationalization - 3 pillars of Japanese Society of Hypertension 2024-2026 advancing hypertension science from Japan to the world in the information network era.
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Kario K, Nishiyama A, Shibata S, Arima H, Furuhashi M, Ichihara A, Ishida M, Katsuya T, Kishi T, Miura K, Miura SI, Mogi M, Ohishi M, Shibata H, Shimosawa T, Sugawara A, Tamura K, Toyoda K, Yamamoto K, and Node K more...
- Abstract
Competing Interests: Compliance with ethical standards. Conflict of interest: Kario K has received grants from A&D, Omron Healthcare, Fukuda Denshi, CureApp, and Sanwa Kagaku Kenkyusho, and honoraria from Daichi Sankyo, Viatris, Novartis, Otsuka Pharmaceuticals, Medtronic, Otsuka Medical Device, and Omron Healthcare. more...
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- 2025
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50. Nonsteroidal MR antagonism in PA: clinical outcomes and unanswered questions.
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Hirohama D and Shibata S
- Abstract
Competing Interests: Compliance with ethical standards. Conflict of interest: S.S. received honoraria from Daiichi-Sankyo. D.H. declares no competing interests.
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- 2025
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