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1. Association of Hospital Volume with Perioperative Mortality of Endovascular Repair of Complex Aortic Aneurysms: A Nationwide Cohort Study

Author: Alberga, Anna J., von Meijenfeldt, Gerdine C. I., Rastogi, Vinamr, de Bruin, Jorg L., Wever, Jan J., van Herwaarden, Joost A., Hamming, Jaap F., Hazenberg, Constantijn E. V. B., van Schaik, Jan, Mees, Barend M. E., van der Laan, Maarten J., Zeebregts, Clark J., Schurink, Geert W. H., Verhagen, Hence J. M., van den Akker, P. J., Akkersdijk, G. P., Akkersdijk, W. L., van Andringa de Kempenaer, M. G., Arts, C. H. P., Avontuur, A. M., Bakker, O. J., Balm, R., Barendregt, W. B., Bekken, J. A., Bender, M. H. M., Bendermacher, B. L. W., van den Berg, M., Beuk, R. J., Blankensteijn, J. D., Bode, A. S., Bodegom, M. E., van der Bogt, K. E. A., Boll, A. P. M., Booster, M. H., Borger van der Burg, B. L. S., de Borst, G. J., Bos-van Rossum, W. T. G. J., Bosma, J., Botman, J. M. J., Bouwman, L. H., Brehm, V., de Bruijn, M. T., de Bruin, J. L., Brummel, P., van Brussel, J. P., Buijk, S. E., Buimer, M. G., Buscher, H. C. J. L., Cancrinus, E., Castenmiller, P. H., Cazander, G., Cuypers, P. W. M., Daemen, J. H. C., Dawson, I., Dierikx, J. E., Dijkstra, M. L., Diks, J., Dinkelman, M. K., Dirven, M., Dolmans, D. E. J. G. J., van Dortmont, L. M. C., Drouven, J. W., van der Eb, M. M., Eefting, D., van Eijck, G. J. W. M., Elshof, J. W. M., Elsman, A. H. P., van der Elst, A., van Engeland, M. I. A., van Eps, G. S., Faber, M. J., de Fijter, W. M., Fioole, B., Fritschy, W. M., Fung Kon Jin, P. H. P., Geelkerken, R. H., van Gent, W. B., Glade, G. J., Govaert, B., Groenendijk, R. P. R., de Groot, H. G. W., van den Haak, R. F. F., de Haan, E. F. A., Hajer, G. F., Hamming, J. F., van Hattum, E. S., Hazenberg, C. E. V. B., Hedeman Joosten, P. P. A., Helleman, J. N., van der Hem, L. G., Hendriks, J. M., van Herwaarden, J. A., Heyligers, J. M. M., Hinnen, J. W., Hissink, R. J., Ho, G. H., den Hoed, P. T., Hoedt, M. T. C., van Hoek, F., Hoencamp, R., Hoffmann, W. H., Hoksbergen, A. W. J., Hollander, E. J. F., Huisman, L. C., Hulsebos, R. G., Huntjens, K. M. B., Idu, M. M., Jacobs, M. J. H. M., van der Jagt, M. F. P., Jansbeken, J. R. H., Janssen, R. J. L., Jiang, H. H. L., de Jong, S. C., Jongbloed-Winkel, T. A., Jongkind, V., Kapma, M. R., Keller, B. P. J. A., Jahrome, A. Khodadade, Kievit, J. K., Klemm, P. L., Klinkert, P., Koedam, N. A., Koelemaij, M. J. W., Kolkert, J. L. P., Koning, G. G., Koning, O. H. J., Konings, R., Krasznai, A. G., Kropman, R. H. J., Kruse, R. R., van der Laan, L., van der Laan, M. J., van Laanen, J. H. H., van Lammeren, G. W., Lamprou, D. A. A., Lardenoije, J. H. P., Lauret, G. J., Leenders, B. J. M., Legemate, D. A., Leij-Dekkers, V. J., Lemson, M. S., Lensvelt, M. M. A., Lijkwan, M. A., van der Linden, F. T. P. M., Lung, P. F. L., Loos, M. J. A., Loubert, M. C., van de Luijtgaarden, K. M., Mahmoud, D. E. A. K., Manshanden, C. G., Mat-Tens, E. C. J. L., Meerwaldt, R., Mees, B. M. E., Menting, T. P., Metz, R., de Mol van Otterloo, J. C. A., Molegraaf, M. J., Montauban van Swijn-Dregt, Y. C. A., Morak, M. J. M., van de Mortel, R. H. W., Mulder, W., Nagesser, S. K., Naves, C. C. L. M., Nederhoed, J. H., Nevenzel, A. M., de Nie, A. J., Nieuwenhuis, D. H., van Nieuwenhuizen, R. C., Nieuwenhui-Zen, J., Nio, D., Oomen, A. P. A., Oranen, B. I., Oskam, J., Palamba, H. W., Peppelenbosch, A. G., van Petersen, A. S., Petri, B. J., Pierie, M. E. N., Ploeg, A. J., Pol, R. A., Ponfoort, E. D., Poyck, P. P. C., Prent, A., ten Raa, S., Raymakers, J. T. F. J., Reichmann, B. L., Reijnen, M. M. P. J., de Ridder, J. A. M., Rijbroek, A., van Rijn, M. J. E., de Roo, R. A., Rouwet, E. V., Saleem, B. R., van Sambeek, M. R. H. M., Samyn, M. G., van't Sant, H. P., van Schaik, J., van Schaik, P. M., Scharn, D. M., Scheltinga, M. R. M., Schepers, A., Schlejen, P. M., Schlösser, F. J. V., Schol, F. P. G., Scholtes, V. P. W., Schouten, O., Schreve, M. A., Schurink, G. W. H., Sikkink, C. J. J. M., te Slaa, A., Smeets, H. J., Smeets, L., Smeets, R. R., de Smet, A. A. E. A., Smit, P. C., Smits, T. M., Snoeijs, M. G. J., Sondakh, A. O., Speijers, M. J., van der Steenhoven, T. J., van Sterkenburg, S. M. M., Stigter, D. A. A., Stokmans, R. A., Strating, R. P., Stultiëns, G. N. M., Sybrandy, J. E. M., Teijink, J. A. W., Telgenkamp, B. J., Testroote, M. J. G., Tha-in, T., The, R. M., Thijsse, W. J., Thomassen, I., Tielliu, I. F. J., van Tongeren, R. B. M., Toorop, R. J., Tournoij, E., Truijers, M., Türkcan, K., Nolthenius, R. P. Tutein, Ünlü, C., Vaes, R. H. D., Vahl, A. C., Veen, E. J., Veger, H. T. C., Veldman, M. G., Verhagen, H. J. M., Verhoeven, B. A. N., Vermeulen, C. F. W., Vermeulen, E. G. J., Vierhout, B. P., van der Vijver-Coppen, R. J., Visser, M. J. T., van der Vliet, J. A., van Vlijmen-van Keulen, C. J., van der Vorst, J. R., Vos, A. W. F., Vos, C. G., Vos, G. A., de Vos, B., Voûte, M. T., Vriens, B. H. R., Vriens, P. W. H. E., de Vries, D. K., de Vries, J. P. P. M., de Vries, M., de Vries, A. C., van der Waal, C., Waasdorp, E. J., de Vries, B. M. Wallis, van Walraven, L. A., van Wanroi, J. L., Warlé, M. C., van Weel, V., van Well, A. M. E., Welten, G. M. J. M., Wever, J. J., Wiersema, A. M., Wikkeling, O. R. M., Willaert, W. I. M., Wille, J., Willems, M. C. M., Willigendael, E. M., Wilschut, E. D., Wisselink, W., Witte, M. E., Wittens, C. H. A., Wong, C. Y., Yazar, O., Yeung, K. K., Zeebregts, C. J. A. M., van Zeeland, M. L. P., Physiology, ACS - Pulmonary hypertension & thrombosis, Surgery, ACS - Atherosclerosis & ischemic syndromes, ACS - Microcirculation, VU University medical center, AII - Inflammatory diseases, APH - Digital Health, Medical Biochemistry, ACS - Diabetes & metabolism, AII - Infectious diseases, and AGEM - Amsterdam Gastroenterology Endocrinology Metabolism
Subjects: volume-outcome, complex AAA, endovascular, mortality
Abstract: Objective: We evaluate nationwide perioperative outcomes of complex EVAR and assess the volume-outcome association of complex EVAR. Summary of Background Data: Endovascular treatment with fenestrated (FEVAR) or branched (BEVAR) endografts is progressively used for excluding complex aortic aneurysms (complex AAs). It is unclear if a volumeoutcome association exists in endovascular treatment of complex AAs (complex EVAR). Methods: All patients prospectively registered in the Dutch Surgical Aneurysm Audit who underwent complex EVAR (FEVAR or BEVAR) between January 2016 and January 2020 were included. The effect of annual hospital volume on perioperative mortality was examined using multivariable logistic regression analyses. Patients were stratified into quartiles based on annual hospital volume to determine hospital volume categories. Results: We included 694 patients (539 FEVAR patients, 155 BEVAR patients). Perioperative mortality following FEVAR was 4.5% and 5.2% following BEVAR. Postoperative complication rates were 30.1% and 48.7%, respectively. The first quartile hospitals performed
Published: 2023
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2. Meta‐analysis of individual‐patient data from EVAR‐1, DREAM, OVER and ACE trials comparing outcomes of endovascular or open repair for abdominal aortic aneurysm over 5 years

Author: Powell, J. T., Sweeting, M. J., Ulug, P., Blankensteijn, J. D., Lederle, F. A., Becquemin, J.‐P., Greenhalgh, R. M., Greenhalgh, R. M., Beard, J. D., Buxton, M. J., Brown, L. C., Harris, P. L., Powell, J. T., Rose, J. D. G., Russell, I. T., Sculpher, M. J., Thompson, S. G., Lilford, R.J., Bell, P. R. F., Greenhalgh, R. M., Whitaker, S.C., Poole‐Wilson, the late P.A., Ruckley, C. V., Campbell, W. B., Dean, M. R. E., Ruttley, M. S. T., Coles, E. C., Powell, J. T., Halliday, A., Gibbs, S. J., Brown, L. C., Epstein, D., Sculpher, M. J., Thompson, S. G., Hannon, R. J., Johnston, L., Bradbury, A. W., Henderson, M. J., Parvin, S. D., Shepherd, D. F. C., Greenhalgh, R. M., Mitchell, A. W., Edwards, P. R., Abbott, G. T., Higman, D. J., Vohra, A., Ashley, S., Robottom, C., Wyatt, M. G., Rose, J. D. G., Byrne, D., Edwards, R., Leiberman, D. P., McCarter, D. H., Taylor, P. R., Reidy, J. F., Wilkinson, A. R., Ettles, D. F., Clason, A. E., Leen, G. L. S., Wilson, N. V., Downes, M., Walker, S. R., Lavelle, J. M., Gough, M. J., McPherson, S., Scott, D. J. A., Kessell, D. O., Naylor, R., Sayers, R., Fishwick, N. G., Harris, P. L., Gould, D. A., Walker, M. G., Chalmers, N. C., Garnham, A., Collins, M. A., Beard, J. D., Gaines, P. A., Ashour, M. Y., Uberoi, R., Braithwaite, B., Whitaker, S. C., Davies, J. N., Travis, S., Hamilton, G., Platts, A., Shandall, A., Sullivan, B. A., Sobeh, M., Matson, M., Fox, A. D., Orme, R., Yusef, W., Doyle, T., Horrocks, M., Hardman, J., Blair, P. H. B., Ellis, P. K., Morris, G., Odurny, A., Vohra, R., Duddy, M., Thompson, M., Loosemore, T. M. L., Belli, A. M., Morgan, R., Adiseshiah, M., Brookes, J. A. S., McCollum, C. N., Ashleigh, R., Aukett, M., Baker, S., Barbe, E., Batson, N., Bell, J., Blundell, J., Boardley, D., Boyes, S., Brown, O., Bryce, J., Carmichael, M., Chance, T., Coleman, J., Cosgrove, C., Curran, G., Dennison, T., Devine, C., Dewhirst, N., Errington, B., Farrell, H., Fisher, C., Fulford, P., Gough, M., Graham, C., Hooper, R., Horne, G., Horrocks, L., Hughes, B., Hutchings, T., Ireland, M., Judge, C., Kelly, L., Kemp, J., Kite, A., Kivela, M., Lapworth, M., Lee, C., Linekar, L., Mahmood, A., March, L., Martin, J., Matharu, N., McGuigen, K., Morris‐Vincent, P., Murray, S., Murtagh, A., Owen, G., Ramoutar, V., Rippin, C., Rowley, J., Sinclair, J., Spencer, S., Taylor, V., Tomlinson, C., Ward, S., Wealleans, V., West, J., White, K., Williams, J., Wilson, L., Grobbee, D. E., Blankensteijn, J. D., Bak, A. A. A., Buth, J., Pattynama, P. M., Verhoeven, E. L. G., van Voorthuisen, A. E., Blankensteijn, J. D., Balm, R., Buth, J., Cuypers, P. W. M., Grobbee, D. E., Prinssen, M., van Sambeek, M. R. H. M., Verhoeven, E. L. G., Baas, A. F., Hunink, M. G., van Engelshoven, J. M., Jacobs, M. J. H. M., de Mol, B. A. J. M., van Bockel, J. H., Balm, R., Reekers, J., Tielbeek, X., Verhoeven, E. L. G., Wisselink, W., Boekema, N., Heuveling, L. M., Sikking, I., Prinssen, M., Balm, R., Blankensteijn, J. D., Buth, J., Cuypers, P. W. M., van Sambeek, M. R. H. M., Verhoeven, E. L. G., de Bruin, J. L., Baas, A. F., Blankensteijn, J. D., Prinssen, M., Buth, J., Tielbeek, A.V., Blankensteijn, J. D., Balm, R., Reekers, J. A., van Sambeek, M. R. H. M., Pattynama, P., Verhoeven, E. L. G., Prins, T., van der Ham, A. C., van der Velden, J. J. I. M., van Sterkenburg, S. M. M., ten Haken, G. B., Bruijninckx, C. M. A., van Overhagen, H., Tutein Nolthenius, R. P., Hendriksz, T. R., Teijink, J. A. W., Odink, H. F., de Smet, A. A. E. A., Vroegindeweij, D., van Loenhout, R. M. M., Rutten, M. J., Hamming, J. F., Lampmann, L. E. H., Bender, M. H. M., Pasmans, H., Vahl, A. C., de Vries, C., Mackaay, A. J. C., van Dortmont, L. M. C., van der Vliet, A. J., Schultze Kool, L. J., Boomsma, J. H. B., van Dop, H. R., de Mol van Otterloo, J. C. A., de Rooij, T. P. W., Smits, T. M., Yilmaz, E. N., Wisselink, W., van den Berg, F. G., Visser, M. J. T., van der Linden, E., Schurink, G. W. H., de Haan, M., Smeets, H. J., Stabel, P., van Elst, F., Poniewierski, J., Vermassen, F. E. G., Lederle, F. A., Freischlag, J. A., Kohler, T. R., Latts, E., Matsumura, J., Padberg, F. T., Jr, Kyriakides, T. C., Swanson, K. M., Guarino, P., Peduzzi, P., Antonelli, M., Cushing, C., Davis, E., Durant, L., Joyner, S., Kossack, the late A., Kyriakides, T. C., LeGwin, Mary, McBride, V., OʼConnor, T., Poulton, J., Stratton, the late S., Zellner, S., Snodgrass, A. J., Thornton, J., Swanson, K. M., Haakenson, C. M., Stroupe, K.T., Jonk, Y., Hallett, J. W., Hertzer, N., Towne, J., Katz, D. A., Karrison, T., Matts, J. P., Marottoli, R., Kasl, S., Mehta, R., Feldman, R., Farrell, W., Allore, H., Perry, E., Niederman, J., Randall, F., Zeman, M., Beckwith, the late D., OʼLeary, T. J., Huang, G. D., Latts, E., Bader, M., Ketteler, E. R., Kingsley, D. D., Marek, J. M., Massen, R. J., Matteson, B. D., Pitcher, J. D., Langsfeld, M., Corson, J. D., Goff, J. M., Jr, Kasirajan, K., Paap, C., Robertson, D. C., Salam, A., Veeraswamy, R., Milner, R., Kasirajan, K., Guidot, J., Lal, B. K., Busuttil, S. J., Lilly, M. P., Braganza, M., Ellis, K., Patterson, M. A., Jordan, W. D., Whitley, D., Taylor, S., Passman, M., Kerns, D., Inman, C., Poirier, J., Ebaugh, J., Raffetto, J., Chew, D., Lathi, S., Owens, C., Hickson, K., Dosluoglu, H. H., Eschberger, K., Kibbe, M. R., Baraniewski, H. M., Matsumura, J., Endo, M., Busman, A., Meadows, W., Evans, M., Giglia, J. S., El Sayed, H., Reed, A. B., Ruf, M., Ross, S., Jean‐Claude, J. M., Pinault, G., Kang, P., White, N., Eiseman, M., Jones, the late R., Timaran, C. H., Modrall, J. G., Welborn, M. B., III, Lopez, J., Nguyen, T., Chacko, J. K. Y., Granke, K., Vouyouka, A. G., Olgren, E., Chand, P., Allende, B., Ranella, M., Yales, C., Whitehill, T. A., Krupski, the late W. C., Nehler, M. R., Johnson, S. P., Jones, D. N., Strecker, P., Bhola, M. A., Shortell, C. K., Gray, J. L., Lawson, J. H., McCann, R., Sebastian, M.W., Kistler Tetterton, J., Blackwell, C., Prinzo, P. A., Lee, N., Padberg, F. T., Jr, Cerveira, J. J., Lal, B. K., Zickler, R. W., Hauck, K. A., Berceli, S. A., Lee, W. A., Ozaki, C. K., Nelson, P. R., Irwin, A. S., Baum, R., Aulivola, B., Rodriguez, H., Littooy, F. N., Greisler, H., OʼSullivan, M. T., Kougias, P., Lin, P. H., Bush, R. L., Guinn, G., Bechara, C., Cagiannos, C., Pisimisis, G., Barshes, N., Pillack, S., Guillory, B., Cikrit, D., Lalka, S. G., Lemmon, G., Nachreiner, R., Rusomaroff, M., OʼBrien, E., Cullen, J. J., Hoballah, J., Sharp, W. J., McCandless, J. L., Beach, V., Minion, D., Schwarcz, T. H., Kimbrough, J., Ashe, L., Rockich, A., Warner‐Carpenter, J., Moursi, M., Eidt, J. F., Brock, S., Bianchi, C., Bishop, V., Gordon, I. L., Fujitani, R., Kubaska, S. M., III, Behdad, M., Azadegan, R., Ma Agas, C., Zalecki, K., Hoch, J. R., Carr, S. C., Acher, C., Schwarze, M., Tefera, G., Mell, M., Dunlap, B., Rieder, J., Stuart, J. M., Weiman, D. S., Abul‐Khoudoud, O., Garrett, H. E., Walsh, S. M., Wilson, K. L., Seabrook, G. R., Cambria, R. A., Brown, K. R., Lewis, B. D., Framberg, S., Kallio, C., Barke, R. A., Santilli, S. M., dʼAudiffret, A. C., Oberle, N., Proebstle, C., Johnson, L. L., Jacobowitz, G. R., Cayne, N., Rockman, C., Adelman, M., Gagne, P., Nalbandian, M., Caropolo, L. J., Pipinos, I. I., Johanning, J., Lynch, T., DeSpiegelaere, H., Purviance, G., Zhou, W., Dalman, R., Lee, J. T., Safadi, B., Coogan, S. M., Wren, S. M., Bahmani, D. D., Maples, D., Thunen, S., Golden, M. A., Mitchell, M. E., Fairman, R., Reinhardt, S., Wilson, M. A., Tzeng, E., Muluk, S., Peterson, N. M., Foster, M., Edwards, J., Moneta, G. L., Landry, G., Taylor, L., Yeager, R., Cannady, E., Treiman, G., Hatton‐Ward, S., Salabsky, the late B., Kansal, N., Owens, E., Estes, M., Forbes, B. A., Sobotta, C., Rapp, J. H., Reilly, L. M., Perez, S. L., Yan, K., Sarkar, R., Dwyer, S. S., Perez, S., Chong, K., Kohler, T. R., Hatsukami, T. S., Glickerman, D. G., Sobel, M., Burdick, T. S., Pedersen, K., Cleary, P., Back, M., Bandyk, D., Johnson, B., Shames, M., Reinhard, R. L., Thomas, S. C., Hunter, G. C., Leon, L. R., Jr, Westerband, A., Guerra, R. J., Riveros, M., Mills, J. L., Sr, Hughes, J. D., Escalante, A. M., Psalms, S. B., Day, N. N., Macsata, R., Sidawy, A., Weiswasser, J., Arora, S., Jasper, B. J., Dardik, A., Gahtan, V., Muhs, B. E., Sumpio, B. E., Gusberg, R. J., Spector, M., Pollak, J., Aruny, J., Kelly, E. L., Wong, J., Vasilas, P., Joncas, C., Gelabert, H. A., DeVirgillio, C., Rigberg, D. A., Cole, L., Becquemin, J.‐P., Marzelle, J., Becquemin, J.‐P., Sapoval, M., Becquemin, J.‐P., Favre, J.‐P., Watelet, J., Lermusiaux, P., Sapoval, M., Lepage, E., Hemery, F., Dolbeau, G., Hawajry, N., Cunin, P., Harris, P., Stockx, L., Chatellier, G., Mialhe, C., Fiessinger, J.‐N., Pagny, L., Kobeiter, H., Boissier, C., Lacroix, P., Ledru, F., Pinot, J.‐J., Deux, J.‐F., Tzvetkov, B., Duvaldestin, P., Watelet, J., Jourdain, C., David, V., Enouf, D., Ady, N., Krimi, A., Boudjema, N., Jousset, Y., Enon, B., Blin, V., Picquet, J., LʼHoste, P., Thouveny, F., Borie, H., Kowarski, S., Pernes, J.‐M., Auguste, M., Becquemin, J.‐P., Desgranges, P., Allaire, E., Marzelle, J., Kobeiter, H., Meaulle, P.‐Y., Chaix, D., Juliae, P., Fabiani, J. N., Chevalier, P., Combes, M., Seguin, A., Belhomme, D., Sapoval, M., Baque, J., Pellerin, O., Favre, J. P., Barral, X., Veyret, C., Watelet, J., Peillon, C., Plissonier, D., Thomas, P., Clavier, E., Lermusiaux, P., Martinez, R., Bleuet, F., C, Dupreix, Verhoye, J. P., Langanay, T., Heautot, J. F., Koussa, M., Haulon, S., Halna, P., Destrieux, L., Lions, C., Wiloteaux, S., Beregi, J. P., Bergeron, P., Pinot, J.‐J., Patra, P., Costargent, A., Chaillou, P., DʼAlicourt, A., Goueffic, Y., Cheysson, E., Parrot, A., Garance, P., Demon, A., Tyazi, A., Pillet, J.‐C., Lescalie, F., Tilly, G., Steinmetz, E., Favier, C., Brenot, R., Krause, D., Cercueil, J. P., Vahdat, O., Sauer, M., Soula, P., Querian, A., Garcia, O., Levade, M., Colombier, D., Cardon, J.‐M., Joyeux, A., Borrelly, P., Dogas, G., Magnan, P.‐É., Branchereau, A., Bartoli, J.‐M., Hassen‐Khodja, R., Batt, M., Planchard, P.‐F., Bouillanne, P.‐J., Haudebourg, P., Bayne, J., Gouny, P., Badra, A., Braesco, J., Nonent, M., Lucas, A., Cardon, A., Kerdiles, Y., Rolland, Y., Kassab, M., Brillu, C., Goubault, F., Tailboux, L., Darrieux, H., Briand, O., Maillard, J.‐C., Varty, K., and Cousins, C.
Published: 2017
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3. Treatment Outcome Trends for Non-Ruptured Abdominal Aortic Aneurysms: A Nationwide Prospective Cohort Study

Author: Alberga, Anna J., Karthaus, Eleonora G., Wilschut, Janneke A., de Bruin, Jorg L., Akkersdijk, George P., Geelkerken, Robert H., Hamming, Jaap F., Wever, Jan J., Verhagen, Hence J. M., van den Akker, P. J., Akkersdijk, G. P., Akkersdijk, W. L., van Andringa de Kempenaer, M. G., Arts, C. H. P., Avontuur, A. M., Bakker, O. J., Balm, R., Barendregt, W. B., Bekken, J. A., Bender, M. H. M., Bendermacher, B. L. W., van den Berg, M., Beuk, R. J., Blankensteijn, J. D., Bode, A. S., Bodegom, M. E., van der Bogt, K. E. A., Boll, A. P. M., Booster, M. H., Borger van der Burg, B. L. S., de Borst, G. J., Bos-van Rossum, W. T. G. J., Bosma, J., Botman, J. M. J., Bouwman, L. H., Brehm, V., de Bruijn, M. T., de Bruin, J. L., Brummel, P., van Brussel, J. P., Buijk, S. E., Buimer, M. G., Buscher, H. C. J. L., Cancrinus, E., Castenmiller, P. H., Cazander, G., Cuypers, P. H. W. M., Daemen, J. H. C., Dawson, I., Dierikx, J. E., Dijkstra, M. L., Diks, J., Dinkelman, M. K., Dirven, M., Dolmans, D. E. J. G. J., van Dortmont, L. M. C., Drouven, J. W., van der Eb, M. M., Eefting, D., van Eijck, G. J. W. M., Elshof, J. W. M., Elsman, B. H. P., van der Elst, A., van Engeland, M. I. A., van Eps, G. S., Faber, M. J., de Fijter, W. M., Fioole, B., Fritschy, W. M., Jin, P. H. P. F. K., Geelkerken, R. H., van Gent, W. B., Glade, G. J., Govaert, B., Groenendijk, R. P. R., de Groot, H. G. W., van den Haak, R. F. F., de Haan, E. F. A., Hajer, G. F., Hamming, J. F., van Hattum, E. S., Hazenberg, C. E. V. B., Hedeman Joosten, P. P. H. A., Helleman, J. N., van der Hem, L. G., Hendriks, J. M., van Herwaarden, J. A., Heyligers, J. M. M., Hinnen, J. W., Hissink, R. J., Ho, G. H., den Hoed, P. T., Hoedt, M. T. C., van Hoek, F., Hoencamp, R., Hoffmann, W. H., Hoksbergen, A. W. J., Hollander, E. J. F., Huisman, L. C., Hulsebos, R. G., Huntjens, K. M. B., Idu, M. M., Jacobs, M. J. H. M., van der Jagt, M. F. P., Jansbeken, J. R. H., Janssen, R. J. L., Jiang, H. H. L., de Jong, S. C., Jongbloed-Winkel, T. A., Jongkind, V., Kapma, M. R., Keller, B. P. J. A., Jahrome, A. K., Kievit, J. K., Klemm, P. L., Klinkert, P., Koedam, N. A., Koelemaij, M. J. W., Kolkert, J. L. P., Koning, G. G., Koning, O. H. J., Konings, R., Krasznai, A. G., Kropman, R. H. J., Kruse, R. R., van der Laan, L., van der Laan, M. J., van Laanen, J. H. H., van Lammeren, G. W., Lamprou, D. A. A., Lardenoije, J. H. P., Lauret, G. J., Leenders, B. J. M., Legemate, D. A., Leijdekkers, V. J., Lemson, M. S., Lensvelt, M. M. A., Lijkwan, M. A., van der Linden, F. T. H. P. M., Lung, P. F. Liqui, Loos, M. J. A., Loubert, M. C., van de Luijtgaarden, K. M., Mahmoud, D. E. A. K., Manshanden, C. G., Mattens, E. C. J. L., Meerwaldt, R., Mees, B. M. E., Menting, T. P., Metz, R., de Mol van Otterloo, J. C. A., Molegraaf, M. J., Montauban van Swijndregt, Y. C. A., Morak, M. J. M., van de Mortel, R. H. W., Mulder, W., Nagesser, S. K., Naves, C. C. L. M., Nederhoed, J. H., Nevenzel, A. M., de Nie, A. J., Nieuwenhuis, D. H., van Nieuwenhuizen, R. C., Nieuwenhuizen, J., Nio, D., Oomen, A. P. A., Oranen, B. I., Oskam, J., Palamba, H. W., Peppelenbosch, A. G., van Petersen, A. S., Petri, B. J., Pierie, M. E. N., Ploeg, A. J., Pol, R. A., Ponfoort, E. D., Poyck, P. P. C., Prent, A., Raa, S. ten, Raymakers, J. T. F. J., Reichmann, B. L., Reijnen, M. M. P. J., de Ridder, J. A. M., Rijbroek, A., van Rijn, M. J. E., de Roo, R. A., Rouwet, E. V., Saleem, B. R., van Sambeek, M. R. H. M., Samyn, M. G., van ’t Sant, H. P., van Schaik, J., van Schaik, P. M., Scharn, D. M., Scheltinga, M. R. M., Schepers, A., Schlejen, P. M., Schlösser, F. J. V., Schol, F. P. G., Scholtes, V. P. W., Schouten, O., Schreve, M. A., Schurink, G. W. H., Sikkink, C. J. J. M., Slaa, A. te, Smeets, H. J., Smeets, L., Smeets, R. R., de Smet, A. A. E. A., Smit, P. C., Smits, T. M., Snoeijs, M. G. J., Sondakh, A. O., Speijers, M. J., van der Steenhoven, T. J., van Sterkenburg, S. M. M., Stigter, D. A. A., Stokmans, R. A., Strating, R. P., Stultiëns, G. N. M., Sybrandy, J. E. M., Teijink, J. A. W., Telgenkamp, B. J., Testroote, M. J. G., Tha-in, T., The, R. M., Thijsse, W. J., Thomassen, I., Tielliu, I. F. J., van Tongeren, R. B. M., Toorop, R. J., Tournoij, E., Truijers, M., Türkcan, K., Tutein Nolthenius, R. P., Ünlü, C., Vaes, R. H. D., Vahl, A. C., Veen, E. J., Veger, H. T. C., Veldman, M. G., Verhagen, H. J. M., Verhoeven, B. A. N., Vermeulen, C. F. W., Vermeulen, E. G. J., Vierhout, B. P., van der Vijver-Coppen, R. J., Visser, M. J. T., van der Vliet, J. A., van Vlijmen - van Keulen, C. J., van der Vorst, J. R., Vos, A. W. F., Vos, C. G., Vos, G. A., de Vos, B., Voûte, M. T., Vriens, B. H. R., Vriens, P. W. H. E., de Vries, D. K., de Vries, J. P. P. M., de Vries, M., de Vries, A. C., van der Waal, C., Waasdorp, E. J., Wallis de Vries, B. M., van Walraven, L. A., van Wanroi, J. L., Warlé, M. C., van Weel, V., van Well, A. M. E., Welten, G. M. J. M., Wever, J. J., Wiersema, A. M., Wikkeling, O. R. M., Willaert, W. I. M., Wille, J., Willems, M. C. M., Willigendael, E. M., Wilschut, E. D., Wisselink, W., Witte, M. E., Wittens, C. H. A., Wong, C. Y., Yazar, O., Yeung, K. K., Zeebregts, C. J. A. M., van Zeeland, M. L. P., ACS - Microcirculation, Anesthesiology, Physiology, ACS - Pulmonary hypertension & thrombosis, Surgery, ACS - Atherosclerosis & ischemic syndromes, VU University medical center, ACS - Diabetes & metabolism, TechMed Centre, Multi-Modality Medical Imaging, Medical Biochemistry, and AGEM - Amsterdam Gastroenterology Endocrinology Metabolism
Subjects: Male, Time Factors, Operative procedure, Vascular damage Radboud Institute for Health Sciences [Radboudumc 16], Risk Assessment, Blood Vessel Prosthesis Implantation, Postoperative Complications, Risk Factors, Humans, Hospital Mortality, Prospective Studies, Registries, Treatment outcome, Aged, Netherlands, Retrospective Studies, Aged, 80 and over, Endovascular Procedures, Quality of care, Middle Aged, Endovascular procedure, Abdominal aortic aneurysm, Surgery, Female, Trends, Cardiology and Cardiovascular Medicine, Aortic Aneurysm, Abdominal
Abstract: Contains fulltext : 251573.pdf (Publisher’s version ) (Open Access) OBJECTIVE: The Dutch Surgical Aneurysm Audit (DSAA) initiative was established in 2013 to monitor and improve nationwide outcomes of aortic aneurysm surgery. The objective of this study was to examine whether outcomes of surgery for intact abdominal aortic aneurysms (iAAA) have improved over time. METHODS: Patients who underwent primary repair of an iAAA by standard endovascular (EVAR) or open surgical repair (OSR) between 2014 and 2019 were selected from the DSAA for inclusion. The primary outcome was peri-operative mortality trend per year, stratified by OSR and EVAR. Secondary outcomes were trends per year in major complications, textbook outcome (TbO), and characteristics of treated patients. The trends per year were evaluated and reported in odds ratios per year. RESULTS: In this study, 11 624 patients (74.8%) underwent EVAR and 3 908 patients (25.2%) underwent OSR. For EVAR, after adjustment for confounding factors, there was no improvement in peri-operative mortality (aOR [adjusted odds ratio] 1.06, 95% CI 0.94 - 1.20), while major complications decreased (2014: 10.1%, 2019: 7.0%; aOR 0.91, 95% CI 0.88 - 0.95) and the TbO rate increased (2014: 68.1%, 2019: 80.9%; aOR 1.13, 95% CI 1.10 - 1.16). For OSR, the peri-operative mortality decreased (2014: 6.1%, 2019: 4.6%; aOR 0.89, 95% CI 0.82 - 0.98), as well as major complications (2014: 28.6%, 2019: 23.3%; aOR 0.95, 95% CI 0.91 - 0.99). Furthermore, the proportion of TbO increased (2014: 49.1%, 2019: 58.3%; aOR 1.05, 95% CI 1.01 - 1.10). In both the EVAR and OSR group, the proportion of patients with cardiac comorbidity increased. CONCLUSION: Since the establishment of this nationwide quality improvement initiative (DSAA), all outcomes of iAAA repair following EVAR and OSR have improved, except for peri-operative mortality following EVAR which remained unchanged.
Published: 2022
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4. A Comparison of Health Status and Quality of Life in Patients with Intermittent Claudication

Author: Roijers, J P, van den Houten, M M L, Hopmans, C J, Vriens, P W H E, Willigendael, E M, Lodder, P, de Vries, J, Teijink, J A W, van der Laan, L, Roijers, J P, van den Houten, M M L, Hopmans, C J, Vriens, P W H E, Willigendael, E M, Lodder, P, de Vries, J, Teijink, J A W, and van der Laan, L
Abstract: BACKGROUND: Patient reported outcome measures (PROMs) such as health status (HS) and quality of life (QOL) are frequently used interchangeably while they represent different outcomes. Whether a discrepancy exists in patients with intermittent claudication (IC) in changes over time between HS and QOL is unclear. This study aimed to investigate the strength and the direction of the association between HS and QOL over time in patients with IC that underwent supervised exercise therapy (SET).MATERIAL AND METHODS: Patients were part of the ELECT multi-center prospective cohort study. One goal of this study was to obtain data on HS and QOL at different time intervals of patients with IC that underwent SET. HS (VascuQOL-6) and QOL (WHOQOL-BREF) were completed at baseline, 3 months, and 6 months follow up. Pearson's correlation coefficients and the associated common variances (R2) were calculated to measure the strength and the direction of the association between HS and QOL in changes between baseline and follow-up moments.RESULTS: In total, 177 patients were included in data analyses. Only changes in physical QOL and overall QOL had a small correlation with changes over time in HS, at both 3- and 6 months follow up (respectively R2=.14; P < 0.001 and R2 = 0.12; P < 0.001 for physical QOL and R2 = 0.18; P < 0.001 and R2 = 0.13; P < 0.001 for overall QOL).CONCLUSIONS: This study showed that HS and QOL provide different outcomes in patients with IC that underwent SET. Future studies should be aware of these differences before PROMs are being incorporated as an outcome measure in clinical studies.
Published: 2022

5. Supervised Exercise Therapy is Effective for Patients With Intermittent Claudication Regardless of Psychological Constructs

Author: Jansen, S. C. P., Hoeks, S. E., Nyklíček, I., Scheltinga, M. R. M., Teijink, J. A. W., Rouwet, E. V., Jansen, S. C. P., Hoeks, S. E., Nyklíček, I., Scheltinga, M. R. M., Teijink, J. A. W., and Rouwet, E. V.
Abstract: Objective: According to current guidelines, supervised exercise therapy (SET) is the treatment of choice for intermittent claudication (IC). Little is known about the potential consequences of psychological factors on the effectiveness of treatment. The aim of this study was to determine possible associations between a set of psychological constructs and treatment outcomes, and to investigate whether self efficacy increased after SET. Methods: This was a substudy of the ELECT Registry, a multicentre Dutch prospective cohort study in patients with IC receiving primary SET. A complete set of validated questionnaires scoring extraversion, neuroticism, conscientiousness, anxiety, depression, self control, optimism, and self efficacy was obtained in 237 patients (median age 69 years, 40% female). Anxiety and depression were dichotomised using established cutoff scores, whereas other scores were analysed as continuous measures. Multiple linear regression analyses determined possible associations between these independent variables and maximum and functional walking distances (MWD and FWD, respectively), Six Minute Walk Test (6MWT), and VascuQol-6 (dependent variables). Self efficacy during 12 months of SET was analysed using a linear mixed model. Results: Neuroticism and anxiety were associated with lower overall VascuQol-6 scores (estimate –1.35 points [standard error (SE) 0.57; p = .018] and –1.98 points [SE 0.87, p = .023], respectively). Optimism and self efficacy demonstrated higher overall 6MWT (5.92 m [SE 2.34; p = .012] and 1.35 m [SE 0.42; p = .001], respectively). Self control was associated with lower overall log MWD (–0.02 [SE 0.01; p = .038] and log FWD (–0.02 [SE 0.01; p = .080), whereas self efficacy had a higher overall log MWD (0.01 [SE 0.003; p = .009]) and log FWD (0.01 [SE 0.003; p = .011]). Depressive patients with IC demonstrated a greater improvement in 6MWT during follow up (17.56 m [SE 8.67; p = .044]), but this small effect was not confirmed i
Published: 2022

6. Serology in chronic Q fever is still surrounded by question marks

Author: Wegdam-Blans, M. C. A., Tjhie, H. T., Korbeeck, J. M., Nabuurs-Franssen, M. N., Kampschreur, L. M., Sprong, T., Teijink, J. A. W., and Koopmans, M. P.
Published: 2014
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7. Attitudes to supervised exercise therapy

Author: Gommans, L. N. M. and Teijink, J. A. W.
Published: 2015
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8. Targeted screening as a tool for the early detection of chronic Q fever patients after a large outbreak

Author: Wegdam-Blans, M. C. A., Stokmans, R. A., Tjhie, J. H. T., Korbeeck, J. M., Koopmans, M. P., Evers, S. M. A. A., van der Voort, P. H., and Teijink, J. A. W.
Published: 2013
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9. Medical management of peripheral arterial disease

Author: BENDERMACHER, B. L. W., WILLIGENDAEL, E. M., TEIJINK, J. A. W., and PRINS, M. H.
Published: 2005

10. Carotid Endarterectomy in Octogenarians with Symptomatic High-Grade Internal Carotid Artery Stenosis: Long-Term Clinical and Duplex Follow-up

Author: Metz, R., Teijink, J. A. W., van de Pavoordt, H. D. W. M., Ackerstaff, R. G. A., de Borst, G. J., Kelder, J. C., and Moll, F. L.
Published: 2002

11. Long-term survival and secondary procedures after open or endovascular repair of abdominal aortic aneurysms

Author: Van Schaik, Theodorus G., Yeung, Kak K., Verhagen, Hence J., De Bruin, Jorg L., Van Sambeek, Marc R H M., Balm, Ron, Zeebregts, Clark J., Van Herwaarden, Joost A., Blankensteijn, Jan D., DREAM Trial Participants, Grobbee, D E., Blankensteijn, J D., Bak, A A A., Buth, J., Pattynama, P M., Verhoeven, E L G., Van Voorthuisen, A E., Balm, R., Cuypers, P W M., Prinssen, M., Van Sambeek, M R H M., Baas, A F., Hunink, M G., Van Engelshoven, J M., Jacobs, M J H M., De Mol, B A J M., Van Bockel, J H., Reekers, J., Tielbeek, X., Wisselink, W., Boekema, N., Heuveling, L M., Sikking, I., De Bruin, J L., Tielbeek, A V., Reekers, J A., Pattynama, P., Prins, T., Van Der Ham, A C., Van Der Velden, J J I M., Van Sterkenburg, S M M., Ten Haken, G B., Bruijninckx, C M A., Van Overhagen, H., Tutein Nolthenius, R P., Hendriksz, T R., Teijink, J A W., Odink, H F., De Smet, A A E A., Vroegindeweij, D., Van Loenhout, R M M., Rutten, M J., Hamming, J F., Lampmann, L E H., Bender, M H M., Pasmans, H., Vahl, A C., De Vries, C., Mackaay, A J C., Van Dortmont, L M C., Van Der Vliet, A J., Schultze Kool, L J., Boomsma, J H B., Van Dop, H R., De Mol Van Otterloo, J C A., De Rooij, T P W., Smits, T M., Yilmaz, E N., Van Den Berg, F G., Visser, M J T., Van Der Linden, E., Schurink, G W H., De Haan, M., Smeets, H J., Stabel, P., Van Elst, F., Poniewierski, J., and Vermassen, F E G.
Abstract: Journal of vascular surgery 66(5), 1379-1389 (2017). doi:10.1016/j.jvs.2017.05.122, Published by Elsevier, Amsterdam [u.a.]
Published: 2017
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12. Improved Adherence to a Stepped-care Model Reduces Costs of Intermittent Claudication Treatment in The Netherlands

Author: Hageman, D., Hageman, D., Fokkenrood, H. J. P., Essers, P. P. M., Koelemay, M. J. W., Breek, J. C., Vahl, A. C., Scheltinga, M. R. M., Teijink, J. A. W., Hageman, D., Hageman, D., Fokkenrood, H. J. P., Essers, P. P. M., Koelemay, M. J. W., Breek, J. C., Vahl, A. C., Scheltinga, M. R. M., and Teijink, J. A. W.
Abstract: Objective/Background: A previous budget impact analysis regarding a supervised exercise therapy (SET) first treatment strategy (stepped care model [SCM]) for Dutch patients with intermittent claudication (IC) showed a low referral rate in 2009, despite solid evidence of the effectiveness of SET programs. Recently, several campaigns have stimulated stakeholders in the field to adopt a SET first strategy in patients with IC. The aim of the present study was to reassess SCM adherence after a 2 year period.Methods: IC related invoices of patients in 2011 were obtained from a large Dutch health insurance company (3.5 million persons). Patients were divided into two groups based on their initial treatment. A SET group had started SET between 12 months before (initiated by general practitioner) and 3 months after (initiated by vascular surgeon) presentation at a vascular surgery outpatient clinic. An intervention (INT) group was treated by revascularisation within 3 months of outpatient presentation. Costs of IC treatment in this 2011 cohort were compared with the earlier 2009 cohort.Results: IC related invoices of 4135 patients were available. In 2011, the initial treatment was SET in 56% (2009: 34%; +22% [p <.001]) and INT in 44% (2009: 66%; -22% [p <.001]) of the IC population. Additional revascularisation was performed in 19% of patients in the SET group (2009: 6%; +13% [p <.001]) and also in 19% of patients in the INT group (2009: 35%; -16% [p <.001]). Later on, 29% of patients in the INT group were referred for SET (2009: 10%; +19% [p <.001]). Average costs of IC treatment per patient in 2011 were 6% lower than in 2009 ((sic)6885 vs. (sic)7300; p = .020).Conclusion: A 22% increase in adherence to SET as a first treatment strategy in Dutch patients with IC was attained between 2009 and 2011. This shift suggests successful SCM implementation resulting in lower costs for the national healthcare system. (C) 2017 European Society for
Published: 2017

13. Predicting reinterventions after open and endovascular aneurysm repair using the St George's Vascular Institute score

Author: De Bruin, Jorg Lucas, Karthikesalingam, Alan, Holt, Peter J., Prinssen, Monique, Thompson, Matt M., Blankensteijn, Jan D., Grobbee, D. E., Blankensteijn, J. D., Bak, A. A A, Buth, J., Pattynama, P. M., Verhoeven, E. L G, Van Voorthuisen, A. E., Balm, R., Cuypers, P. W M, Prinssen, M., Van Sambeek, M. R H M, Baas, A. F., Hunink, M. G., Van Engelshoven, J. M., Jacobs, M. J H M, De Mol, B. A J M, Van Bockel, J. H., Reekers, J., Tielbeek, X., Wisselink, W., Boekema, N., Heuveling, L. M., Sikking, I., De Bruin, J. L., Tielbeek, A. V., Reekers, J. A., Pattynama, P., Prins, T., Van Der Ham, A. C., Van Der Velden, J. J I M, Van Sterkenburg, S. M M, Ten Haken, G. B., Bruijninckx, C. M A, Van Overhagen, H., Tutein Nolthenius, R. P., Hendriksz, T. R., Teijink, J. A W, Odink, H. F., De Smet, A. A E A, Vroegindeweij, D., Van Loenhout, R. M M, Rutten, M. J., Hamming, J. F., Lampmann, L. E H, Bender, M. H M, Pasmans, H., Vahl, A. C., De Vries, C., MacKaay, A. J C, Van Dortmont, L. M C, Van Der Vliet, A. J., Schultze Kool, L. J., Boomsma, J. H B, Van, H. R., De Mol Van Otterloo, J. C A, De Rooij, T. P W, Smits, T. M., Yilmaz, E. N., Van Den Berg, F. G., Visser, M. J T, Van Der Linden, E., Schurink, G. W H, De Haan, M., Smeets, H. J., Stabel, P., Van Elst, F., Poniewierski, J., Vermassen, F. E G, De Bruin, Jorg Lucas, Karthikesalingam, Alan, Holt, Peter J., Prinssen, Monique, Thompson, Matt M., Blankensteijn, Jan D., Grobbee, D. E., Blankensteijn, J. D., Bak, A. A A, Buth, J., Pattynama, P. M., Verhoeven, E. L G, Van Voorthuisen, A. E., Balm, R., Cuypers, P. W M, Prinssen, M., Van Sambeek, M. R H M, Baas, A. F., Hunink, M. G., Van Engelshoven, J. M., Jacobs, M. J H M, De Mol, B. A J M, Van Bockel, J. H., Reekers, J., Tielbeek, X., Wisselink, W., Boekema, N., Heuveling, L. M., Sikking, I., De Bruin, J. L., Tielbeek, A. V., Reekers, J. A., Pattynama, P., Prins, T., Van Der Ham, A. C., Van Der Velden, J. J I M, Van Sterkenburg, S. M M, Ten Haken, G. B., Bruijninckx, C. M A, Van Overhagen, H., Tutein Nolthenius, R. P., Hendriksz, T. R., Teijink, J. A W, Odink, H. F., De Smet, A. A E A, Vroegindeweij, D., Van Loenhout, R. M M, Rutten, M. J., Hamming, J. F., Lampmann, L. E H, Bender, M. H M, Pasmans, H., Vahl, A. C., De Vries, C., MacKaay, A. J C, Van Dortmont, L. M C, Van Der Vliet, A. J., Schultze Kool, L. J., Boomsma, J. H B, Van, H. R., De Mol Van Otterloo, J. C A, De Rooij, T. P W, Smits, T. M., Yilmaz, E. N., Van Den Berg, F. G., Visser, M. J T, Van Der Linden, E., Schurink, G. W H, De Haan, M., Smeets, H. J., Stabel, P., Van Elst, F., Poniewierski, J., and Vermassen, F. E G
Published: 2016

14. Predicting reinterventions after open and endovascular aneurysm repair using the St George's Vascular Institute score

Author: Cardiovasculaire Epi Team 9, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Genetica Klinische Genetica, Arts Assistenten CTC, Psychiatrie_Medisch, Pathologie Pathologen staf, Arts-assistenten Radiologie, PCR MN, Other research (not in main researchprogram), JC Overig onderzoek, De Bruin, Jorg Lucas, Karthikesalingam, Alan, Holt, Peter J., Prinssen, Monique, Thompson, Matt M., Blankensteijn, Jan D., Grobbee, D. E., Blankensteijn, J. D., Bak, A. A A, Buth, J., Pattynama, P. M., Verhoeven, E. L G, Van Voorthuisen, A. E., Balm, R., Cuypers, P. W M, Prinssen, M., Van Sambeek, M. R H M, Baas, A. F., Hunink, M. G., Van Engelshoven, J. M., Jacobs, M. J H M, De Mol, B. A J M, Van Bockel, J. H., Reekers, J., Tielbeek, X., Wisselink, W., Boekema, N., Heuveling, L. M., Sikking, I., De Bruin, J. L., Tielbeek, A. V., Reekers, J. A., Pattynama, P., Prins, T., Van Der Ham, A. C., Van Der Velden, J. J I M, Van Sterkenburg, S. M M, Ten Haken, G. B., Bruijninckx, C. M A, Van Overhagen, H., Tutein Nolthenius, R. P., Hendriksz, T. R., Teijink, J. A W, Odink, H. F., De Smet, A. A E A, Vroegindeweij, D., Van Loenhout, R. M M, Rutten, M. J., Hamming, J. F., Lampmann, L. E H, Bender, M. H M, Pasmans, H., Vahl, A. C., De Vries, C., MacKaay, A. J C, Van Dortmont, L. M C, Van Der Vliet, A. J., Schultze Kool, L. J., Boomsma, J. H B, Van, H. R., De Mol Van Otterloo, J. C A, De Rooij, T. P W, Smits, T. M., Yilmaz, E. N., Van Den Berg, F. G., Visser, M. J T, Van Der Linden, E., Schurink, G. W H, De Haan, M., Smeets, H. J., Stabel, P., Van Elst, F., Poniewierski, J., Vermassen, F. E G, Cardiovasculaire Epi Team 9, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Genetica Klinische Genetica, Arts Assistenten CTC, Psychiatrie_Medisch, Pathologie Pathologen staf, Arts-assistenten Radiologie, PCR MN, Other research (not in main researchprogram), JC Overig onderzoek, De Bruin, Jorg Lucas, Karthikesalingam, Alan, Holt, Peter J., Prinssen, Monique, Thompson, Matt M., Blankensteijn, Jan D., Grobbee, D. E., Blankensteijn, J. D., Bak, A. A A, Buth, J., Pattynama, P. M., Verhoeven, E. L G, Van Voorthuisen, A. E., Balm, R., Cuypers, P. W M, Prinssen, M., Van Sambeek, M. R H M, Baas, A. F., Hunink, M. G., Van Engelshoven, J. M., Jacobs, M. J H M, De Mol, B. A J M, Van Bockel, J. H., Reekers, J., Tielbeek, X., Wisselink, W., Boekema, N., Heuveling, L. M., Sikking, I., De Bruin, J. L., Tielbeek, A. V., Reekers, J. A., Pattynama, P., Prins, T., Van Der Ham, A. C., Van Der Velden, J. J I M, Van Sterkenburg, S. M M, Ten Haken, G. B., Bruijninckx, C. M A, Van Overhagen, H., Tutein Nolthenius, R. P., Hendriksz, T. R., Teijink, J. A W, Odink, H. F., De Smet, A. A E A, Vroegindeweij, D., Van Loenhout, R. M M, Rutten, M. J., Hamming, J. F., Lampmann, L. E H, Bender, M. H M, Pasmans, H., Vahl, A. C., De Vries, C., MacKaay, A. J C, Van Dortmont, L. M C, Van Der Vliet, A. J., Schultze Kool, L. J., Boomsma, J. H B, Van, H. R., De Mol Van Otterloo, J. C A, De Rooij, T. P W, Smits, T. M., Yilmaz, E. N., Van Den Berg, F. G., Visser, M. J T, Van Der Linden, E., Schurink, G. W H, De Haan, M., Smeets, H. J., Stabel, P., Van Elst, F., Poniewierski, J., and Vermassen, F. E G
Published: 2016

15. Cost-effectiveness of supervised exercise therapy compared with endovascular revascularization for intermittent claudication

Author: van den Houten, M M L, primary, Lauret, G J, additional, Fakhry, F, additional, Fokkenrood, H J P, additional, van Asselt, A D I, additional, Hunink, M G M, additional, and Teijink, J A W, additional
Published: 2016
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16. How Well Do Randomized Controlled Trials Reflect Standard Care: A Comparison between Scientific Research Data and Standard Care Data in Patients with Intermittent Claudication undergoing Supervised Exercise Therapy

Author: Dörenkamp, S., primary, Mesters, E. P. E., additional, Nijhuis-van der Sanden, M. W. G., additional, Teijink, J. A. W., additional, de Bie, R. A., additional, and Hoogeboom, T. J., additional
Published: 2016
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17. Influence of gender on EVAR outcomes with new low-profile devices

Author: Bendermacher, Bianca L. W., Grootenboer, N., Cuypers, Ph. W. M., Teijink, J. A. W., Van Sambeek, Marc R. H. M., Epidemiologie, Surgery, and RS: CAPHRI School for Public Health and Primary Care
Subjects: Cardiovascular diseases, Endovascular procedures, Gender
Abstract: Women have not benefitted to the same extent as men of endovascular abdominal aortic repair (EVAR). Besides differences in hormones and the higher rate of undiagnosed cardiovascular disease, there are anatomical differences between men and women influencing the outcome of endovascular treatment of abdominal aortic aneurysms (AAA). After the first decade of EVAR procedures, only 28% of women with an elective AAA were treated by EVAR due to their poor anatomical suitability for this technique. The anatomical challenges and their associated poorer outcomes suggest the need for advances in device design to better meet the specific female aneurysm anatomy and physiology. Most of the newer-generation endografts have been associated with lower incidences of graft occlusion compared with first-generation endografts, and might be more suitable for women. It is encouraging that EVAR has decreased long-term mortality in women and that women's survival begins to equal men's after 2 years. However, detailed, adjusted anatomical data from population-based samples are needed for better understanding of the differences in AAA anatomy and EVAR eligibility. This information will contribute to enhance the design, testing and evaluation of future stent grafts, to ensure that women will benefit from EVAR to the same extent as men.
Published: 2013

18. Systematic approach to ruptured abdominal aortic aneurysm in the endovascular era: Intention-to-treat eEVAR protocol

Author: Willigendael, Edith M., Cuypers, P.W., Teijink, J. A. W., Van Sambeek, Marc R. H. M., Epidemiologie, and RS: CAPHRI School for Public Health and Primary Care
Subjects: Enclovascular procedures, Clinical protocols, Aortic rupture
Abstract: Emergency endovascular aneurysm repair (eEVAR) for ruptured abdominal aortic aneurysms (rAAA) is still a relatively new treatment option. A pre-defined strategy of an eEVAR first approach for rAAA is associated with improved mortality rates. After establishing and implementing the Intention-to-treat eEVAR protocol for rAAAs the mortality and morbidity rates improved significantly. The presented Intention-to-treat eEVAR protocol starts at the first telephone call to the ambulance department and lasts until the post-operative care unit. The protocol involves the close collaboration between the ambulance department, vascular surgeon, emergency department physicians, anaesthesiologists, operating room staff and, radiology technicians. The availability of a variety of off-the-shelf stent-grafts, and an operating room that is adequately equipped to perform endovascular procedures is crucial in obtaining better outcomes. High volume centres that offer open surgical repair as well as eEVAR for rAAA show that the Intention-to-treat eEVAR protocol is achievable and appears to be associated with favorable mortality over open repair with appropriate case selection. Unstable or older patients with rAAA may particularly benefit by eEVAR.
Published: 2012

19. ENDOGRAFT TREATMENT OF RUPTURED ABDOMINAL AORTIC ANEURYSMS USING TALENT AORTOUNIILIAC SYSTEM: AN INTERNATIONAL MULTICENTER STUDY

Author: Peppelenbosch, N., Geelkerken, R., Soong, C., Cao, Piergiorgio, Steinmetz, O., Teijink, J. A. W., Lepantalo, M., DE LETTER, J., Vermassen, F. G., Derose, G., Buskens, E., and Buth, J.
Subjects: endograft treatment of ruptured abdominal aortic aneurysms
Published: 2006

20. Treatment for intermittent claudication and the effects on walking distance and quality of life

Author: Kruidenier, Lotte M., Kruidenier, Lotte M., Viechtbauer, W., Nicolai, S. P., Buller, H.R., Prins, M. H., Teijink, J. A. W., Kruidenier, Lotte M., Kruidenier, Lotte M., Viechtbauer, W., Nicolai, S. P., Buller, H.R., Prins, M. H., and Teijink, J. A. W.
Abstract: The objective of the study was to provide an overview of the most common treatments for intermittent claudication and to determine the effectiveness in improving walking distance and quality of life based on a combination of direct and indirect evidence. We included trials that compared: angioplasty, surgery, exercise therapy or no treatment for intermittent claudication. Outcome measurements were walking distance (maximum, pain-free) and quality of life (physical, mental). We used a network meta-analysis model for the combination of direct and indirect evidence. We included 42 studies, presenting 3106 participants. The network meta-analysis showed that supervised exercise therapy (Delta = 1.62, P <0.01), angioplasty (Delta = 1.89, P <0.01) and surgery (Delta = 2.72, P = 0.02) increased walking distance significantly more than no treatment. Furthermore, supervised exercise therapy (Delta = 0.60, P <0.01), angioplasty (Delta = 0.91, P = 0.01) and surgery (Delta = 1.07, P <0.01) increased physical quality of life more than no treatment. However, in the sensitivity analysis, only supervised exercise therapy had additional value over no symptomatic treatment (Delta = 0.66, P <0.01). In conclusion, this network meta-analysis indicates that supervised exercise therapy is more effective in both increasing walking distance and physical quality of life, compared with no treatment. Angioplasty and surgery also increase walking distance, compared with no treatment, but results for physical quality of life are less convincing.
Published: 2012

21. Targeted screening as a tool for the early detection of chronic Q fever patients after a large outbreak

Author: Wegdam-Blans, M. C. A., primary, Stokmans, R. A., additional, Tjhie, J. H. T., additional, Korbeeck, J. M., additional, Koopmans, M. P., additional, Evers, S. M. A. A., additional, Voort, P. H., additional, and Teijink, J. A. W., additional
Published: 2012
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22. Early and mid-term results of a prospective observational study comparing emergency endovascular aneurysm repair with open surgery in both ruptured and unruptured acute abdominal aortic aneurysms

Author: Ten Bosch, J A, primary, Willigendael, E M, additional, Kruidenier, L M, additional, de Loos, E R, additional, Prins, M H, additional, and Teijink, J A W, additional
Published: 2012
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23. Treatment for intermittent claudication and the effects on walking distance and quality of life

Author: Kruidenier, L M, primary, Viechtbauer, W, additional, Nicolaï, S P, additional, Büller, H, additional, Prins, M H, additional, and Teijink, J A W, additional
Published: 2012
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24. Supervised Exercise Therapy for Intermittent Claudication

Author: Bendermacher, B. L. W., primary, Kruidenier, L. M., additional, Nicolaï, S. P. A., additional, Welten, R. J. Th. J., additional, and Teijink, J. A. W., additional
Published: 2007
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25. Editor's Choice - The Effect of Supervision on Walking Distance in Patients with Intermittent Claudication: A Meta-analysis.

Author: Gommans, L. N. M., Saarloos, R., Scheltinga, M. R. M., Houterman, S., de Bie, R. A., Fokkenrood, H. J. P., and Teijink, J. A. W.
Abstract: Background A number of reviews have reported the influence of exercise therapy (ET) for the treatment of intermittent claudication (IC). However, a complete overview of different types of ET is lacking. The aim of this meta-analysis was to study the effect of supervision on walking capacity in patients with IC. It was hypothesized that there was a positive treatment effect in relation to the intensity of supervision and improvement in walking capacity (i.e., a "dose-response" hypothesis). Methods A systematic search in the Cochrane Central Register of Controlled Trials, MEDLINE, and EMBASE databases was performed. Only randomized controlled trials (RCTs) evaluating the efficacy of an ET in IC were included. Type of supervision, treadmill protocol, length of ET, total training volume, and change in walking distance were extracted. RCTs were categorised according to type of support: no exercise, walking advice, home-based exercise (HB-ET), and supervised exercise therapy (SET). A standardised mean difference between pre- and post-training maximal walking distance (MWD) and pain-free walking distance (PFWD) was calculated for all subgroups at 6 weeks, and 3 and 6 months of follow up. Results Thirty studies involving 1406 patients with IC were included. The overall quality was moderate-to-good, although number of included patients varied widely (20-304). The intensity of supervision was directly related to MWD and PFWD. SET was superior to other conservative treatment regimens with respect to improvement in walking distances at all follow-ups. However, the difference between HB-ET and SET at 6 months of follow up was not significant. Conclusion Supervised exercise therapy for intermittent claudication is superior to all other forms of exercise therapy. Intensity of supervision is related to improved walking distance. [ABSTRACT FROM AUTHOR]
Published: 2014
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26. Physical Activity Monitoring in Patients with Peripheral Arterial Disease: Validation of an Activity Monitor.

Author: Fokkenrood, H. J. P., Verhofstad, N., van den Houten, M. M. L., Lauret, G. J., Wittens, C., Scheltinga, M. R. M., and Teijink, J. A. W.
Abstract: Objectives The daily life physical activity (PA) of patients with peripheral arterial disease (PAD) may be severely hampered by intermittent claudication (IC). From a therapeutic, as well as research, point of view, it may be more relevant to determine improvement in PA as an outcome measure in IC. The aim of this study was to validate daily activities using a novel type of tri-axial accelerometer (Dynaport MoveMonitor) in patients with IC. Methods Patients with IC were studied during a hospital visit. Standard activities (locomotion, lying, sitting, standing, shuffling, number of steps and "not worn" detection) were video recorded and compared with activities scored by the MoveMonitor. Inter-rater reliability (expressed in intraclass correlation coefficients [ICC]), sensitivity, specificity, and positive predictive values (PPV) were calculated for each activity. Results Twenty-eight hours of video observation were analysed (n = 21). Our video annotation method (the gold standard method) appeared to be accurate for most postures (ICC > 0.97), except for shuffling (ICC = 0.38). The MoveMonitor showed a high sensitivity (>86%), specificity (>91%), and PPV (>88%) for locomotion, lying, sitting, and "not worn" detection. Moderate accuracy was found for standing (46%), while shuffling appeared to be undetectable (18%). A strong correlation was found between video recordings and the MoveMonitor with regard to the calculation of the "number of steps" (ICC = 0.90). Conclusions The MoveMonitor provides accurate information on a diverse set of postures, daily activities, and number of steps in IC patients. However, the detection of low amplitude movements, such as shuffling and "sitting to standing" transfers, is a matter of concern. This tool is useful in assessing the role of PA as a novel, clinically relevant outcome parameter in IC. [ABSTRACT FROM AUTHOR]
Published: 2014
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27. Early and mid-term results of a prospective observational study comparing emergency endovascular aneurysm repair with open surgery in both ruptured and unruptured acute abdominal aortic aneurysms.

Author: Bosch, J. A. Ten, Willigendael, E. M., Kruidenier, L. M., de Loos, E. R., Prins, M. H., and Teijink, J. A. W.
Abstract: The aim of the paper is to prospectively describe early and mid-term outcomes for emergency endovascular aneurysm repair (eEVAR) versus open surgery in acute abdominal aortic aneurysms (aAAAs), both unruptured (symptomatic) and ruptured. We enrolled all consecutive patients treated for aAAA at our center between April 2002 and April 2008. The main outcome parameters were 30-day, 6- and 12-month mortality (all-cause and aneurysm-related). Two hundred forty patients were enrolled in the study. In the unruptured aAAA group (n = 111), 47 (42%) underwent eEVAR. The 30-day, 6- and 12-month mortality rates were 6, 13 and 15% in the eEVAR group versus 11% (NS), 13% (NS) and 16% (NS) in the open group, respectively. In the ruptured aAAA group (n = 129), 25 (19%) underwent eEVAR (mortality rates: 20, 28 and 36%, respectively) compared with 104 (81%) patients who underwent open surgery (mortality rates: 45% (P = 0.021), 60% (P = 0.004) and 63% (P = 0.014), respectively). In conclusion, the present study showed a reduced 30-day, 6- and 12-month mortality of eEVAR compared with open surgery in all patients with aAAA, mainly due to a lower mortality in the ruptured aAAA group. Late aneurysm-related mortality occurred only in the eEVAR group. [ABSTRACT FROM AUTHOR]
Published: 2012
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28. The ClaudicationNet concept: design of a national integrated care network of supervised exercise therapy for patients with intermittent claudication.

Author: Lauret, G. J., van Dalen, H. C. W., Hendriks, H. J. M., Spronk, S., Rouwet, E. V., de Bie, R. A., and Teijink, J. A. W.
Subjects: INTERMITTENT claudication, ARTERIAL diseases
Published: 2011

29. Scoring multitrauma patients: which scoring system?

Author: Teijink, J. A. W., Dwars, B. J., Patka, P., and Haarman, H. J. T. M.
Published: 1993
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30. A Comparison of Health Status and Quality of Life in Patients with Intermittent Claudication.

Author: Roijers JP, van den Houten MML, Hopmans CJ, Vriens PWHE, Willigendael EM, Lodder P, de Vries J, Teijink JAW, and van der Laan L
Subjects: Aged, Female, Humans, Intermittent Claudication diagnosis, Intermittent Claudication physiopathology, Male, Middle Aged, Netherlands, Prospective Studies, Time Factors, Treatment Outcome, Exercise Therapy, Health Status, Intermittent Claudication therapy, Patient Reported Outcome Measures, Quality of Life
Abstract: Background: Patient reported outcome measures (PROMs) such as health status (HS) and quality of life (QOL) are frequently used interchangeably while they represent different outcomes. Whether a discrepancy exists in patients with intermittent claudication (IC) in changes over time between HS and QOL is unclear. This study aimed to investigate the strength and the direction of the association between HS and QOL over time in patients with IC that underwent supervised exercise therapy (SET)., Material and Methods: Patients were part of the ELECT multi-center prospective cohort study. One goal of this study was to obtain data on HS and QOL at different time intervals of patients with IC that underwent SET. HS (VascuQOL-6) and QOL (WHOQOL-BREF) were completed at baseline, 3 months, and 6 months follow up. Pearson's correlation coefficients and the associated common variances (R 2 ) were calculated to measure the strength and the direction of the association between HS and QOL in changes between baseline and follow-up moments., Results: In total, 177 patients were included in data analyses. Only changes in physical QOL and overall QOL had a small correlation with changes over time in HS, at both 3- and 6 months follow up (respectively R 2 =.14; P < 0.001 and R 2 = 0.12; P < 0.001 for physical QOL and R 2 = 0.18; P < 0.001 and R 2 = 0.13; P < 0.001 for overall QOL)., Conclusions: This study showed that HS and QOL provide different outcomes in patients with IC that underwent SET. Future studies should be aware of these differences before PROMs are being incorporated as an outcome measure in clinical studies., (Copyright © 2021 Elsevier Inc. All rights reserved.)
Published: 2022
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31. Improved Adherence to a Stepped-care Model Reduces Costs of Intermittent Claudication Treatment in The Netherlands.

Author: Hageman D, Fokkenrood HJP, Essers PPM, Koelemay MJW, Breek JC, Vahl AC, Scheltinga MRM, and Teijink JAW
Subjects: Aged, Aged, 80 and over, Budgets, Cost Savings, Cost-Benefit Analysis, Databases, Factual, Female, Humans, Intermittent Claudication diagnosis, Intermittent Claudication physiopathology, Male, Middle Aged, Netherlands, Peripheral Arterial Disease diagnosis, Peripheral Arterial Disease physiopathology, Recovery of Function, Retrospective Studies, Time Factors, Treatment Outcome, Exercise Therapy economics, Guideline Adherence economics, Health Care Costs, Intermittent Claudication economics, Intermittent Claudication therapy, Peripheral Arterial Disease economics, Peripheral Arterial Disease therapy, Practice Guidelines as Topic, Practice Patterns, Physicians' economics, Process Assessment, Health Care economics
Abstract: Objective/background: A previous budget impact analysis regarding a supervised exercise therapy (SET) first treatment strategy (stepped care model [SCM]) for Dutch patients with intermittent claudication (IC) showed a low referral rate in 2009, despite solid evidence of the effectiveness of SET programs. Recently, several campaigns have stimulated stakeholders in the field to adopt a SET first strategy in patients with IC. The aim of the present study was to reassess SCM adherence after a 2 year period., Methods: IC related invoices of patients in 2011 were obtained from a large Dutch health insurance company (3.5 million persons). Patients were divided into two groups based on their initial treatment. A SET group had started SET between 12 months before (initiated by general practitioner) and 3 months after (initiated by vascular surgeon) presentation at a vascular surgery outpatient clinic. An intervention (INT) group was treated by revascularisation within 3 months of outpatient presentation. Costs of IC treatment in this 2011 cohort were compared with the earlier 2009 cohort., Results: IC related invoices of 4135 patients were available. In 2011, the initial treatment was SET in 56% (2009: 34%; +22% [p < .001]) and INT in 44% (2009: 66%; -22% [p < .001]) of the IC population. Additional revascularisation was performed in 19% of patients in the SET group (2009: 6%; +13% [p < .001]) and also in 19% of patients in the INT group (2009: 35%; -16% [p < .001]). Later on, 29% of patients in the INT group were referred for SET (2009: 10%; +19% [p < .001]). Average costs of IC treatment per patient in 2011 were 6% lower than in 2009 (€6885 vs. €7300; p = .020)., Conclusion: A 22% increase in adherence to SET as a first treatment strategy in Dutch patients with IC was attained between 2009 and 2011. This shift suggests successful SCM implementation resulting in lower costs for the national healthcare system., (Copyright © 2017 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.)
Published: 2017
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32. [Neurogenic thoracic outlet syndrome].

Author: Teijink JAW, Pesser N, van Grinsven R, van Suijlekom H, van Sambeek MRHM, and van Nuenen BFL
Subjects: Adolescent, Adult, Brachial Plexus, Female, Humans, Male, Neurosurgical Procedures, Treatment Outcome, Decompression, Surgical, Thoracic Outlet Syndrome diagnosis, Thoracic Outlet Syndrome surgery
Abstract: Neurogenic thoracic outlet syndrome (nTOS) is a type of thoracic outlet syndrome (TOS) where compression of the brachial plexus is responsible for development of upper-extremity, head and neck symptoms. We present a 16-year-old and a 34-year-old patient with nTOS. Diagnosis in both cases was done by following the recently published reporting standards for (n)TOS. After this multidisciplinary diagnostic work-up we performed a transaxillary thoracic outlet decompression (TOD). Due to lack of literature, difficult nomenclature and complexity of diagnosis and treatment, diagnosis of nTOS is often delayed. Recent experience shows that treatment of nTOS is safe and effective, both in the short term and the long term.
Published: 2017

33. Development of quality indicators for physiotherapy for patients with PAOD in the Netherlands: a Delphi study.

Author: Gijsbers HJ, Lauret GJ, van Hofwegen A, van Dockum TA, Teijink JA, and Hendriks HJ
Subjects: Adult, Delphi Technique, Female, Humans, Male, Middle Aged, Netherlands, Practice Guidelines as Topic, Intermittent Claudication rehabilitation, Physical Therapy Modalities standards, Quality Indicators, Health Care standards
Abstract: Objectives: The aim of the study was to develop quality indicators (QIs) for physiotherapy management of patients with intermittent claudication (IC) in the Netherlands., Design: As part of an international six-step method to develop QIs, an online survey Delphi-procedure was completed. After two Delphi-rounds a validation round was performed., Participants: Twenty-six experts were recruited to participate in this study. Twenty-four experts completed two Delphi-rounds. A third round was conducted inviting 1200 qualified and registered physiotherapists of the Dutch integrated care network 'Claudicationet' to validate a draft set of quality indicators., Results: Out of 83 potential QIs in the Dutch physiotherapy guideline on 'Intermittent claudication', consensus among the experts selected nine indicators. All nine quality indicators were validated by 300 physiotherapists., Conclusion: A final set of nine indicators was derived from (1) a Dutch evidence-based physiotherapy guideline, (2) an expert Delphi procedure and (3) a validation by 300 physiotherapists. This set of indicators should be validated in clinical practice., (Copyright © 2015 Chartered Society of Physiotherapy. Published by Elsevier Ltd. All rights reserved.)
Published: 2016
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34. Minimally Important Difference of the Absolute and Functional Claudication Distance in Patients with Intermittent Claudication.

Author: van den Houten MM, Gommans LN, van der Wees PJ, and Teijink JA
Subjects: Aged, Exercise Test, Female, Follow-Up Studies, Humans, Intermittent Claudication diagnosis, Intermittent Claudication rehabilitation, Male, Retrospective Studies, Severity of Illness Index, Time Factors, Treatment Outcome, Exercise Therapy methods, Intermittent Claudication physiopathology, Surveys and Questionnaires, Walking physiology
Abstract: Objective: Disease severity and treatment outcomes in patients with intermittent claudication (IC) are commonly assessed using walking distance measured with a standardized treadmill test. It is unclear what improvement or deterioration in walking distance constitutes a meaningful, clinically relevant, change from the patients' perspective. The purpose of the present study was to estimate the minimally important difference (MID) for the absolute claudication distance (ACD) and functional claudication distance (FCD) in patients with IC., Method: The MIDs were estimated using an anchor based approach with a previously defined clinical anchor derived from scores of the walking impairment questionnaire (WIQ) in a similar IC population. Baseline and 3 month follow up data on WIQ scores and walking distances (ACD and FCD) were used from 202 patients receiving supervised exercise therapy from the 2010 EXITPAD randomized controlled trial. The external WIQ anchor was used to form three distinct categories: patients with "clinically relevant improvement," "clinically relevant deterioration," and "no clinically relevant change." The MIDs for improvement and deterioration were defined by the upper and lower limits of the 95% confidence interval of the mean change in ACD and FCD, for the group of IC patients that remained unchanged according to the WIQ anchor., Results: For the estimation of the MID of the ACD and FCD, 102 and 101 patients were included, respectively. The MID for the ACD was 305 m for improvement, and 147 m for deterioration. The MID for the FCD was 250 m for improvement, and 120 m for deterioration., Conclusion: The MIDs for the treadmill measured ACD and FCD can be used to interpret the clinical relevance of changes in walking distances after supervised exercise therapy and may be used in both research and individual care., (Copyright © 2015 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.)
Published: 2016
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35. Venous Side Branch Ligation as a First Step Treatment for Haemodialysis Access Induced Hand Ischaemia: Effects on Access Flow Volume and Digital Perfusion.

Author: Vaes RH, Wouda R, Teijink JA, and Scheltinga MR
Subjects: Aged, Blood Flow Velocity, Brachial Artery physiopathology, Female, Graft Occlusion, Vascular diagnosis, Graft Occlusion, Vascular etiology, Graft Occlusion, Vascular physiopathology, Humans, Ischemia diagnosis, Ischemia etiology, Ischemia physiopathology, Ligation, Male, Plethysmography, Regional Blood Flow, Reoperation, Surveys and Questionnaires, Time Factors, Treatment Outcome, Ultrasonography, Doppler, Duplex, Vascular Patency, Veins physiopathology, Arteriovenous Shunt, Surgical adverse effects, Brachial Artery surgery, Graft Occlusion, Vascular surgery, Hand blood supply, Ischemia surgery, Renal Dialysis, Veins surgery
Abstract: Objective: Haemodialysis access induced distal ischemia (HAIDI) induced by an autogenous arteriovenous fistula (AVF) is caused by loss of blood pressure somewhere along the arterial blood supply of the arm. In some patients, side branches of the access' venous outflow tract may contribute to this blood pressure loss. Beneficial effects of side branch ligation (SBL) as a first step approach to ischemic symptoms have been reported. However, effects on access flow and AVF function after prolonged follow up are unknown., Materials and Methods: Prior to SBL, HAIDI patients with a brachial artery based AVF were studied using a questionnaire quantifying hand ischemia, digital brachial index (DBI, finger plethysmography), and Duplex analysis. Access flow volume, patency rates, hand perfusion, and complications were determined during a 12 month observation period following SBL., Results: In 9 years, SBLs were performed in 20 haemodialysis patients, either as a single operative procedure (n = 10) or supplemented (n = 10) with additional surgical techniques during the same procedure (banding, n = 5; basilic vein transposition, n = 4; DRIL, n = 1). Follow up data after 12 months were available in 18 patients. One patient with progressive hand ischemia required access ligation 3 months after SBL. Hand ischemia was attenuated or abolished in the remaining 17 patients (94% clinical success rate). DBI improved from 0.51 ± 0.05 (pre-operative) to 0.68 ± 0.04 (immediate post-operative) and 0.83 ± 0.07 (at 1 year follow up). One year primary, assisted primary, and secondary patency rates were 67% (12/18), 83% (15/18), and 94% (17/18), respectively, while mean access flows remained acceptable at 710 ± 70 mL/min., Conclusions: Ligation of non-functional venous side branches of an autogenous brachial artery AVF causing hand ischemia leads to prolonged attenuation of hand ischemia whereas access flow volumes are maintained after 1 year of follow up. Side branch ligation must be considered prior to embarking on more invasive surgery for HAIDI., (Copyright © 2015 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.)
Published: 2015
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36. Response to 'Re: Endovascular Treatment of Ruptured Abdominal Aortic Aneurysms with Hostile Aortic Neck Anatomy'.

Author: Broos PP, 't Mannetje YW, Cuypers PW, van Sambeek MR, and Teijink JA
Subjects: Female, Humans, Male, Aortic Aneurysm, Abdominal surgery, Aortic Rupture surgery, Endovascular Procedures
Published: 2015
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37. Endovascular Treatment of Ruptured Abdominal Aortic Aneurysms with Hostile Aortic Neck Anatomy.

Author: Broos PP, 't Mannetje YW, Cuypers PW, van Sambeek MR, and Teijink JA
Subjects: Aged, Aged, 80 and over, Aortic Aneurysm, Abdominal diagnosis, Aortic Aneurysm, Abdominal mortality, Aortic Rupture diagnosis, Aortic Rupture mortality, Aortography methods, Blood Vessel Prosthesis Implantation adverse effects, Blood Vessel Prosthesis Implantation mortality, Endoleak etiology, Female, Hospitals, High-Volume, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Netherlands, Retrospective Studies, Risk Factors, Time Factors, Tomography, X-Ray Computed, Treatment Outcome, Aortic Aneurysm, Abdominal surgery, Aortic Rupture surgery, Endovascular Procedures adverse effects, Endovascular Procedures mortality
Abstract: Objective: To compare the mid-term results of endovascular aortic aneurysm repair (EVAR) for ruptured abdominal aortic aneurysms (RAAAs) in patients with favourable aortic neck anatomy (FNA) and hostile aortic neck anatomy (HNA)., Methods: Patients treated for a RAAA in a high volume endovascular centre in the Netherlands between February 2009 and January 2014 were identified retrospectively and divided into two groups based on aortic neck anatomy, FNA and HNA. HNA was defined as RAAA with a proximal neck of <10 mm, or a proximal neck of 10-15 mm with a suprarenal angulation (α) >45° and/or an infrarenal angulation (β) >60°, or a proximal neck of >15 mm combined with α >60° and/or β >75°. Patient demographics, procedure details, 30 day and 1 year outcomes were recorded., Results: Of 39 included patients, 17 (44%) had HNA. Technical success was 100% for FNA and 88% for HNA (p = .184). There were no type IA endoleaks on completion angiography in either group; however, more adjunctive procedures were necessary for intra-operative type IA endoleaks in the HNA group (24% vs. 0%, p = .029). Thirty day mortality rates were comparable, FNA 14% vs. HNA 12% (p = 1.000). There were no statistically significant differences at 1 year follow up in type I endoleaks, secondary endovascular procedures, or all cause mortality., Conclusion: Emergency EVAR provides excellent results for treatment of RAAA patients with both FNA and HNA. EVAR in RAAAs with HNA is technically feasible and safe in experienced endovascular centres. Article history., (Copyright © 2015 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.)
Published: 2015
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38. The effect of supervised exercise therapy on physical activity and ambulatory activities in patients with intermittent claudication.

Author: Fokkenrood HJ, Lauret GJ, Verhofstad N, Bendermacher BL, Scheltinga MR, and Teijink JA
Subjects: Actigraphy, Aged, Aged, 80 and over, Exercise Tolerance, Female, Health Behavior, Humans, Intermittent Claudication diagnosis, Intermittent Claudication physiopathology, Intermittent Claudication psychology, Male, Middle Aged, Netherlands, Peripheral Arterial Disease diagnosis, Peripheral Arterial Disease physiopathology, Peripheral Arterial Disease psychology, Sedentary Behavior, Time Factors, Treatment Outcome, Walking, Exercise Therapy, Intermittent Claudication therapy, Motor Activity, Peripheral Arterial Disease therapy
Abstract: Objective/background: Intermittent claudication (IC) is associated with a reduction in physical activity (PA) and a more rapid functional decline leading to a higher mortality rate compared with healthy individuals. Supervised exercise therapy (SET) is known to increase the walking capacity of patients with IC. However, it is unclear whether SET increases PA. The aim of this study was to investigate the effect of SET on PA levels and ambulatory activities in patients with IC., Methods: Patients newly diagnosed with IC were requested to wear an activity monitor 1 week prior to and 1 week immediately after 3 months of SET. The primary outcome was the percentage of patients meeting the minimum recommendations of PA (American College of Sports Medicine [ACSM]/American Heart Association [AHA] recommendation for public health of ≥ 67 metabolic equivalents [METs]/min/day, in bouts of ≥ 10 min) at baseline and after 3 months of SET. Additionally, daily PA level (METs/min), duration of ambulatory activities, daily number of steps, pain free walking distance (PFWD), maximal walking distance (MWD), and Short Form Health Survey (SF-36) health surveys were compared before and after SET., Results: Data from 41 participants were available for analysis. A higher number of participants met the ACSM minimum recommendation for PA at the 3 month follow up (baseline: 43%; 3 months: 63%; p = .003). Despite significant increases in PFWD (baseline: 210 m; 3 months: 390 m; p = .001), MWD (baseline: 373 m; 3 months: 555 m; p = .002) and physical functioning score (SF-36) following SET, no increase in the mean daily PA level was found (395 ± 220 vs. 411 ± 228 METs/min; p = .43). Furthermore, the total number of steps and time spent in ambulatory activities did not change following SET., Conclusion: Three months of SET for IC leads to more patients meeting the ACSM/AHA public health minimum recommendations for PA. Assessment of PA could be incorporated as an outcome parameter in future research comparing different treatment modalities for peripheral arterial disease., (Copyright © 2014 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.)
Published: 2015
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39. Beneficial Effects of Pre-operative Exercise Therapy in Patients with an Abdominal Aortic Aneurysm: A Systematic Review.

Author: Pouwels S, Willigendael EM, van Sambeek MR, Nienhuijs SW, Cuypers PW, and Teijink JA
Subjects: Hemodynamics, Humans, Patient Satisfaction, Physical Fitness, Postoperative Complications prevention & control, Respiratory Function Tests, Risk Reduction Behavior, Treatment Outcome, Aortic Aneurysm, Abdominal rehabilitation, Aortic Aneurysm, Abdominal surgery, Exercise Therapy, Preoperative Care
Abstract: Objective/background: The impact of post-operative complications in abdominal aortic aneurysm (AAA) surgery is substantial, and increases with age and concomitant co-morbidities. This systematic review focuses on the possible effects of pre-operative exercise therapy (PET) in patients with AAA on post-operative complications,aerobic capacity, physical fitness, and recovery., Methods: A systematic search on PET prior to AAA surgery was conducted. The methodological quality of the included studies was rated using the Physiotherapy Evidence Database scale. The agreement between the reviewers was assessed with Cohen's kappa., Results: Five studies were included, with a methodological quality ranging from moderate to good. Cohen's kappa was 0.79. Three studies focused on patients with an AAA (without indication for surgical repair) with physical fitness as the outcome measure. One study focused on PET in patients awaiting AAA surgery and one study focused on the effects of PET on post-operative complications, length of stay, and recovery., Conclusion: PET has beneficial effects on various physical fitness variables of patients with an AAA. Whether this leads to less complications or faster recovery remains unclear. In view of the large impact of post-operative complications, it is valuable to explore the possible benefits of a PET program in AAA surgery.
Published: 2015
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40. Significant savings with a stepped care model for treatment of patients with intermittent claudication.

Author: Fokkenrood HJ, Scheltinga MR, Koelemay MJ, Breek JC, Hasaart F, Vahl AC, and Teijink JA
Subjects: Aged, Cost Savings, Cost-Benefit Analysis, Female, Follow-Up Studies, Guidelines as Topic, Hospital Costs, Humans, Male, Netherlands, Retrospective Studies, Exercise Therapy economics, Intermittent Claudication economics, Intermittent Claudication therapy, Models, Organizational, Vascular Surgical Procedures economics
Abstract: Objectives: International guidelines recommend supervised exercise therapy (SET) as primary treatment for intermittent claudication (IC). The aim of this study was to calculate treatment costs in patients with IC and to estimate nationwide annual savings if a stepped care model (SCM, primary SET treatment followed by revascularization in case of SET failure) was followed., Methods: Invoice data of all patients with IC in 2009 were obtained from a Dutch health insurance company (3.4 million members). Patients were divided into three groups based on initial treatment after diagnosis (t0). The SET group received SET initiated at any time between 12 months before and up to 3 months after t0. The intervention group (INT) underwent endovascular or open revascularization between t0 and t+3 months. The third group (REST) received neither SET nor any intervention. All peripheral arterial disease related invoices were recorded during 2 years and average costs per patient were calculated. Savings following use of a SCM were calculated for three scenarios., Results: Data on 4954 patients were analyzed. Initial treatment was SET (n = 701, 14.1%), INT (n = 1363, 27.5%), or REST (n = 2890, 58.3%). Within 2 years from t0, invasive revascularization in the SET group was performed in 45 patients (6.4%). Additional interventions (primary at other location and/or re-interventions) were performed in 480 INT patients (35.2%). Some 431 REST patients received additional SET (n = 299, 10.3%) or an intervention (n = 132, 4.5%). Mean total IC related costs per patient were €2,191, €9851 and €824 for SET, INT, and REST, respectively. Based on a hypothetical worst, moderate, and best case scenario, some 3.8, 20.6, or 33.0 million euros would have been saved per annum if SCM was implemented in the Dutch healthcare system., Conclusion: Implementation of a SCM treatment for patients with IC may lead to significant savings of health care resources., (Copyright © 2014 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.)
Published: 2014
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41. Rationale and design of the EAGLE Registry: EVAR with Endurant® in challenging anatomy.

Author: Stokmans RA, Broos PP, Cuypers PW, Forbes TL, Vahl AC, Swartbol P, Van Sambeek MR, and Teijink JA
Subjects: Aortic Aneurysm, Abdominal diagnosis, Blood Vessel Prosthesis Implantation adverse effects, Databases, Factual, Endovascular Procedures adverse effects, Humans, Prospective Studies, Prosthesis Design, Risk Factors, Time Factors, Treatment Outcome, Aortic Aneurysm, Abdominal surgery, Blood Vessel Prosthesis, Blood Vessel Prosthesis Implantation instrumentation, Endovascular Procedures instrumentation, Registries, Research Design, Stents
Abstract: Aim: The aim of this study was to collect clinical information on the performance of the Endurant® (II) Stent Graft System for endovascular repair in anatomically challenging infrarenal aneurysms, and to critically assess whether the current instructions for anatomic eligibility for endovascular treatment with this system are still applicable., Methods: Initiated by doctors, EAGLE is a prospective, non-interventional study, aiming to enrol 250 patients in 20 experienced centres across several countries worldwide. EAGLE focuses on patients with challenging angulation or neck length. To minimize the risk of selection bias and enhance data quality, EAGLE eligibility will be determined by an independent core-lab and efforts will be made to secure consecutive enrolment of challenging cases. The EAGLE database is designed to merge with the on-going ENGAGE database, which enables comparative analysis of cases and results., Results: The primary endpoint is treatment success at 30 days, 12 months and yearly up to 5 years postimplant., Conclusion: Separate studies on the performance of EVAR in challenging anatomy are necessary to demonstrate safety and effectiveness of the latest generation stent-grafts, which is essential in making a balanced judgment about the optimal management of AAAs.
Published: 2014

42. Physical activity monitoring in patients with intermittent claudication.

Author: Lauret GJ, Fokkenrood HJ, Bendermacher BL, Scheltinga MR, and Teijink JA
Subjects: Activities of Daily Living, Aged, Awareness, Case-Control Studies, Equipment Design, Female, Health Behavior, Health Knowledge, Attitudes, Practice, Humans, Intermittent Claudication physiopathology, Male, Middle Aged, Patient Compliance, Predictive Value of Tests, Prospective Studies, Sedentary Behavior, Time Factors, Actigraphy instrumentation, Intermittent Claudication diagnosis, Motor Activity
Abstract: Objectives: Reduced physical activity (PA) is associated with a higher mortality rate and more rapid functional decline in patients with intermittent claudication (IC). The newest generation of accelerometers can assess both direction and intensity of activities three-dimensionally and may also adequately calculate energy expenditure in daily life. The aim of this study was to quantify daily PA level and energy expenditure of newly diagnosed patients with IC and healthy controls. PA outcomes are compared with contemporary public health physical activity guidelines., Methods: Before initiating treatment, 94 patients with newly diagnosed IC and 36 healthy controls were instructed to wear a tri-axial seismic accelerometer for 1 week. Daily PA levels (in metabolic equivalents, METs) were compared with the ACSM/AHA public health PA minimum recommendations (≥64 METs·min·day, in bouts of ≥10 minutes). A subgroup analysis assessed the effect of functional impairment on daily PA levels., Results: Data from 56 IC patients and 27 healthy controls were available for analysis. Patients with IC demonstrated significantly lower mean daily PA levels (±SD) than controls (387 ± 198 METs·min vs. 500 ± 156 METs·min, p = .02). This difference was solely attributable to a subgroup of IC patients with the largest functional impairment (WIQ-score < 0.4). Only 45% of IC patients met the public health physical activity guidelines compared with 74% of the healthy controls (p = .01)., Conclusions: More than half of patients with IC do not meet recommended standards of PA. Considering the serious health risks associated with low PA levels, these findings underscore the need for more awareness to improve physical exercise in patients with IC., (Copyright © 2014 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.)
Published: 2014
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43. Editor's choice--Use of disposable radiation-absorbing surgical drapes results in significant dose reduction during EVAR procedures.

Author: Kloeze C, Klompenhouwer EG, Brands PJ, van Sambeek MR, Cuypers PW, and Teijink JA
Subjects: Equipment Design, Humans, Operating Room Nursing, Radiometry, Endovascular Procedures, Occupational Health, Radiology, Interventional, Surgical Drapes
Abstract: Objectives: Because of the increasing number of interventional endovascular procedures with fluoroscopy and the corresponding high annual dose for interventionalists, additional dose-protecting measures are desirable. The purpose of this study was to evaluate the effect of disposable radiation-absorbing surgical drapes in reducing scatter radiation exposure for interventionalists and supporting staff during an endovascular aneurysm repair (EVAR) procedure., Materials: This was a randomized control trial in which 36 EVAR procedures were randomized between execution with and without disposable radiation-absorbing surgical drapes (Radpad: Worldwide Innovations & Technologies, Inc., Kansas City, US, type 5511A). Dosimetric measurements were performed on the interventionalist (hand and chest) and theatre nurse (chest) with and without the use of the drapes to obtain the dose reduction and effect on the annual dose caused by the drapes., Results: Use of disposable radiation-absorbing surgical drapes resulted in dose reductions of 49%, 55%, and 48%, respectively, measured on the hand and chest of the interventionalist and the chest of the theatre nurse., Conclusions: The use of disposable radiation-absorbing surgical drapes significantly reduces scatter radiation exposure for both the interventionalist and the supporting staff during EVAR procedures., (Copyright © 2013 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.)
Published: 2014
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44. Influence of gender on EVAR outcomes with new low-profile devices.

Author: Bendermacher BL, Grootenboer N, Cuypers PW, Teijink JA, and Van Sambeek MR
Subjects: Aortic Aneurysm, Abdominal diagnostic imaging, Aortic Aneurysm, Abdominal mortality, Aortic Aneurysm, Abdominal physiopathology, Blood Vessel Prosthesis Implantation adverse effects, Blood Vessel Prosthesis Implantation mortality, Endovascular Procedures adverse effects, Endovascular Procedures mortality, Female, Graft Occlusion, Vascular, Health Status Disparities, Healthcare Disparities, Humans, Male, Patient Selection, Prosthesis Design, Radiography, Risk Factors, Sex Factors, Time Factors, Treatment Outcome, Aortic Aneurysm, Abdominal surgery, Blood Vessel Prosthesis, Blood Vessel Prosthesis Implantation instrumentation, Endovascular Procedures instrumentation, Hemodynamics
Abstract: Women have not benefitted to the same extent as men of endovascular abdominal aortic repair (EVAR). Besides differences in hormones and the higher rate of undiagnosed cardiovascular disease, there are anatomical differences between men and women influencing the outcome of endovascular treatment of abdominal aortic aneurysms (AAA). After the first decade of EVAR procedures, only 28% of women with an elective AAA were treated by EVAR due to their poor anatomical suitability for this technique. The anatomical challenges and their associated poorer outcomes suggest the need for advances in device design to better meet the specific female aneurysm anatomy and physiology. Most of the newer-generation endografts have been associated with lower incidences of graft occlusion compared with first-generation endografts, and might be more suitable for women. It is encouraging that EVAR has decreased long-term mortality in women and that women's survival begins to equal men's after 2 years. However, detailed, adjusted anatomical data from population-based samples are needed for better understanding of the differences in AAA anatomy and EVAR eligibility. This information will contribute to enhance the design, testing and evaluation of future stent grafts, to ensure that women will benefit from EVAR to the same extent as men.
Published: 2013

45. Response to 're. internal iliac artery coverage during endovascular aneurysm repair'.

Author: Stokmans RA, Cuypers PW, van Sambeek MR, and Teijink JA
Subjects: Female, Humans, Male, Embolization, Therapeutic methods, Endoleak surgery, Iliac Aneurysm surgery, Iliac Artery surgery
Published: 2013
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46. Challenging the evidence for pre-emptive coil embolisation of the internal iliac artery during endovascular aneurysm repair.

Author: Stokmans RA, Willigendael EM, Teijink JA, Ten Bosch JA, van Sambeek MR, and Cuypers PW
Subjects: Aged, Aged, 80 and over, Embolization, Therapeutic adverse effects, Endoleak epidemiology, Female, Follow-Up Studies, Humans, Iliac Artery pathology, Male, Middle Aged, Postoperative Complications epidemiology, Retrospective Studies, Stents adverse effects, Treatment Outcome, Embolization, Therapeutic methods, Endoleak surgery, Iliac Aneurysm surgery, Iliac Artery surgery
Abstract: Objectives: We retrospectively analysed the results of a strategy in which coverage of the internal iliac artery (IIA) during endovascular aneurysm repair (EVAR) was routinely performed without coil embolisation., Methods: From January 2010 until May 2012, 32 patients (96.9% men; mean age 73.0 years, range 52-89 years) underwent EVAR with stent grafts extended into the external iliac artery (EIA), all without prior coil embolisation. Aneurysm morphology was determined on preoperative computed tomography (CT) images. During follow-up, patients were interviewed about buttock claudication, and the occurrence of endoleaks and evolution of aneurysm diameter were recorded., Results: At baseline, the mid-common iliac artery (CIA) diameter was 33.5 ± 16.8 mm and seven patients presented with ruptured aneurysms. Mean follow-up was 14.3 ± 7.4 months. There were eight deaths, none related to IIA coverage. Buttock claudication occurred in seven (22.6%) patients, which persisted after 6 months in two cases of bilateral IIA coverage. No Type-I or -II endoleaks occurred related to IIA coverage. Aneurysm growth was not observed., Conclusion: Endovascular treatment of aortoiliac and iliac aneurysm without pre-emptive coil embolisation of the IIA appears safe and effective. No IIA-related endoleaks or re-interventions occurred in our series. This approach saves operating time, contrast load and costs and may reduce complications. However, a larger population and longer follow-up is required to confirm our findings., (Copyright © 2012 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.)
Published: 2013
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47. Early results from the ENGAGE registry: real-world performance of the Endurant Stent Graft for endovascular AAA repair in 1262 patients.

Author: Stokmans RA, Teijink JA, Forbes TL, Böckler D, Peeters PJ, Riambau V, Hayes PD, and van Sambeek MR
Subjects: Adult, Aged, Aged, 80 and over, Aortic Aneurysm, Abdominal diagnostic imaging, Aortic Aneurysm, Abdominal mortality, Europe epidemiology, Female, Follow-Up Studies, Humans, Male, Middle Aged, Prospective Studies, Prosthesis Design, Survival Rate trends, Time Factors, Tomography, X-Ray Computed, Treatment Outcome, Aortic Aneurysm, Abdominal surgery, Blood Vessel Prosthesis, Endovascular Procedures methods, Registries, Stents
Abstract: Objective: The ENGAGE registry was undertaken to examine the real-world outcome after endovascular abdominal aortic aneurysm (AAA) repair (EVAR) with the Endurant Stent Graft in a large, contemporary, global series of patients., Methods: From March 2009 to April 2011, 1262 AAA patients (89.6% men; mean age 73.1 years, range 43-93 years) were enrolled from 79 sites in 30 countries and treated with Endurant. Results are described following the reporting standards for EVAR. Follow-up data were tabulated for all 1262 patients at a 30-day follow-up and for the first 500 patients at a 1-year follow-up., Results: Intra-operative technical success was achieved in 99.0% of cases. Within 30 days, adverse events were reported in 3.9% of patients, including a 1.3% mortality rate. Type-I or -III endoleaks were identified in 1.5% of cases. Estimated overall survival, aneurysm-related survival and freedom from secondary interventions at 1 year were 91.6%, 98.6% and 95.1%, respectively. At 1 year, aneurysm size increased ≥ 5 mm in 2.8% and decreased ≥ 5 mm in 41.3% of cases., Conclusion: Early results from this real world, global experience are promising and indicate that endovascular AAA repair with the Endurant Stent Graft is safe and effective across different geographies and standards of practice. Longer-term follow-up is necessary to assess durability of these results., (Copyright © 2012 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.)
Published: 2012
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48. EVAR reintervention management strategies in contemporary practice.

Author: Bendermacher BL, Stokmans R, Cuypers PW, Teijink JA, and Van Sambeek MR
Subjects: Angioplasty, Balloon instrumentation, Blood Vessel Prosthesis, Blood Vessel Prosthesis Implantation adverse effects, Device Removal, Embolization, Therapeutic, Endoleak etiology, Endoleak surgery, Endovascular Procedures adverse effects, Foreign-Body Migration etiology, Foreign-Body Migration surgery, Humans, Prosthesis Design, Reoperation, Stents, Thrombolytic Therapy, Treatment Outcome, Aneurysm surgery, Blood Vessel Prosthesis Implantation instrumentation, Endoleak therapy, Endovascular Procedures instrumentation, Foreign-Body Migration therapy, Prosthesis Failure
Abstract: It is known that following an endovascular aneurysm repair (EVAR) procedure, patients may experience endoleaks, device migration, stent fractures, graft deterioration, or aneurysm growth that might require a reintervention. In this review management strategies of reinterventions after EVAR in contemporary practice will be discussed. The current endovascular treatment options of Type I endoleak involve securing of the attachment site with percutaneous transluminal balloon angioplasty, stent-graft extension, or placement of a stent at the proximal attachment site. Moreover, the use of endostaples to secure the position of the proximal cuff to the primary endograft have been developed. Type II endoleaks can be managed conservatively if the aneurysm is shrinking or remains stable. Otherwise, reinterventions include transarterial embolization, translumbar embolization, transcaval embolization, direct thrombin injection, and endoscopic or open ligation of the lumbar and mesenteric arteries. There is little debate regarding the treatment of type III endoleaks, including deployement of additional stent graft components to bridge the defect. Endovascular treatment of endotension includes endovascular conversion stent or relining of the stent graft. Alternative options are puncture of the aneurysm sac and removal of the aneurysm sac content. In case of migration large balloon-expandable stents can be used to improve the seal between the components, or devices that deploy staples to secure endovascular grafts to the aortic wall to secure endovascular components together. In conclusion, the first treatment options for reinterventions after EVAR are catheter based nowadays.
Published: 2012

49. No differences in perioperative outcome between symptomatic and asymptomatic AAAs after EVAR: an analysis from the ENGAGE Registry.

Author: Stokmans RA, Teijink JA, Cuypers PW, Riambau V, and van Sambeek MR
Subjects: Abdominal Pain etiology, Aged, Aged, 80 and over, Aortic Aneurysm, Abdominal complications, Aortic Aneurysm, Abdominal mortality, Asymptomatic Diseases, Back Pain etiology, Blood Vessel Prosthesis, Elective Surgical Procedures, Female, Humans, Logistic Models, Male, Middle Aged, Multivariate Analysis, Prosthesis Design, Registries, Retrospective Studies, Risk Assessment, Risk Factors, Stents, Time Factors, Treatment Outcome, Aortic Aneurysm, Abdominal surgery, Blood Vessel Prosthesis Implantation adverse effects, Blood Vessel Prosthesis Implantation instrumentation, Blood Vessel Prosthesis Implantation mortality, Endovascular Procedures adverse effects, Endovascular Procedures instrumentation, Endovascular Procedures mortality
Abstract: Aim: This study aimed to compare the differences in perioperative outcome after endovascular repair of symptomatic abdominal aneurysms (S-AAAs) and elective non-symptomatic AAAs (E-AAAs). Data from the ENGAGE Registry were used for the analysis., Methods: Between March 2009 and December 2010, 1200 AAA patients were enrolled from 79 sites in 30 countries and treated with an Endurant Stent Graft. S-AAAs defined as AAAs accompanied by abdominal or back pain, without rupture, were present in 185 (15.4%) patients and E-AAAs in 1015 (84.6%) patients. Multivariate logistic regression was used to compare results., Results: At baseline, E-AAA patients had larger aneurysms on average (P = 0.006) and scored higher ASA classification more often (P = 0.001). Further analyses were corrected for baseline differences. Operation time and technical success were comparable, and S-AAAs were admitted to the Intensive Care Unit (ICU) as often as E-AAAs (35.7% vs. 33.4%, P = 0.479). Post-operative hospitalisation was similar (4.83 ± 5.29 in E-AAAs and 4.37 ± 3.49 in S-AAAs, P = 0.360). No differences in the occurrence of major adverse events, including mortality, within the 30-day post-implantation were seen between S-AAA and E-AAA patients, respectively, 3.2% and 4.2% (P = 0.572)., Conclusion: With contemporary devices and technical proficiency, there is no difference in outcome between symptomatic AAA and elective non-symptomatic AAA patients if treated with endovascular techniques., (Copyright © 2012 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.)
Published: 2012
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50. Systematic approach to ruptured abdominal aortic aneurysm in the endovascular era: Intention-to-treat eEVAR protocol.

Author: Willigendael EM, Cuypers PW, Teijink JA, and Van Sambeek MR
Subjects: Aneurysm, Ruptured mortality, Aortic Aneurysm, Abdominal mortality, Global Health, Humans, Rupture, Spontaneous, Survival Rate trends, Aneurysm, Ruptured surgery, Aortic Aneurysm, Abdominal surgery, Emergencies, Endovascular Procedures methods, Intention to Treat Analysis
Abstract: Emergency endovascular aneurysm repair (eEVAR) for ruptured abdominal aortic aneurysms (rAAA) is still a relatively new treatment option. A pre-defined strategy of an eEVAR first approach for rAAA is associated with improved mortality rates. After establishing and implementing the Intention-to-treat eEVAR protocol for rAAAs the mortality and morbidity rates improved significantly. The presented Intention-to-treat eEVAR protocol starts at the first telephone call to the ambulance department and lasts until the post-operative care unit. The protocol involves the close collaboration between the ambulance department, vascular surgeon, emergency department physicians, anaesthesiologists, operating room staff and, radiology technicians. The availability of a variety of off-the-shelf stent-grafts, and an operating room that is adequately equipped to perform endovascular procedures is crucial in obtaining better outcomes. High volume centres that offer open surgical repair as well as eEVAR for rAAA show that the Intention-to-treat eEVAR protocol is achievable and appears to be associated with favorable mortality over open repair with appropriate case selection. Unstable or older patients with rAAA may particularly benefit by eEVAR.
Published: 2012

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