Search

Your search keyword '"Teijeira, Álvaro"' showing total 126 results
Start Over Author "Teijeira, Álvaro"
126 results on '"Teijeira, Álvaro"'

1. DSTYK Inhibition Sensitizes NSCLC to Taxane-Based Chemotherapy

Author

Echepare, Mirari, Picabea, Beñat, Arricibita, Andrea, Teijeira, Álvaro, Pasquier, Andrea, Zandueta, Carolina, Otegui, Nerea, Santamaría, Enrique, Fernández-Irigoyen, Joaquín, Romero, Octavio, Sanchez-Cespedes, Montse, Lecanda, Fernando, Hernández, Javier, Felip, Enriqueta, Cruz-Bermúdez, Alberto, Provencio, Mariano, Gentili, Marco, Facchinetti, Federica, Roz, Luca, Montuenga, Luis M., and Valencia, Karmele

Published
2024
Full Text
View/download PDF

2. Intratumoral immunotherapy with mRNAs encoding chimeric protein constructs encompassing IL-12, CD137 agonists, and TGF-β antagonists

Author

Cirella, Assunta, Bolaños, Elixabet, Luri-Rey, Carlos, Di Trani, Claudia Augusta, Olivera, Irene, Gomis, Gabriel, Glez-Vaz, Javier, Pinci, Beatrice, Garasa, Saray, Sánchez-Gregorio, Sandra, Azpilikueta, Arantza, Eguren-Santamaria, Iñaki, Valencia, Karmele, Palencia, Belén, Alvarez, Maite, Ochoa, Maria C., Teijeira, Álvaro, Berraondo, Pedro, and Melero, Ignacio

Published
2023
Full Text
View/download PDF

3. Intratumoral injection of IL-12-encoding mRNA targeted to CSF1R and PD-L1 exerts potent anti-tumor effects without substantial systemic exposure

Author

Di Trani, Claudia Augusta, Cirella, Assunta, Arrizabalaga, Leire, Alvarez, Maite, Bella, Ángela, Fernandez-Sendin, Myriam, Russo-Cabrera, Joan Salvador, Gomar, Celia, Ardaiz, Nuria, Teijeira, Alvaro, Bolaños, Elixabet, González-Gomariz, José, Otano, Itziar, Aranda, Fernando, Palencia, Belén, Segués, Aina, Huang, Shuyu, van Duijnhoven, Sander M.J., van Elsas, Andrea, Melero, Ignacio, and Berraondo, Pedro

Published
2023
Full Text
View/download PDF

4. Neutrophil Extracellular Traps, Local IL-8 Expression, and Cytotoxic T-Lymphocyte Response in the Lungs of Patients With Fatal COVID-19

Author

Melero, Ignacio, Villalba-Esparza, María, Recalde-Zamacona, Borja, Jiménez-Sánchez, Daniel, Teijeira, Álvaro, Argueta, Alan, García-Tobar, Laura, Álvarez-Gigli, Laura, Sainz, Cristina, Garcia-Ros, David, Toledo, Estefanía, Abengozar-Muela, Marta, Fernández-Alonso, Mirian, Rodríguez-Mateos, Mariano, Reina, Gabriel, Carmona-Torre, Francisco, Quiroga, Jorge Augusto, Del Pozo, Jose L., Cross, Amy, López-Janeiro, Álvaro, Hardisson, David, Echeveste, José I., Lozano, Maria D., Ho, Ling-Pei, Klenerman, Paul, Issa, Fadi, Landecho, Manuel F., and de Andrea, Carlos E.

Published
2022
Full Text
View/download PDF

5. Antitumor efficacy and reduced toxicity using an anti-CD137 Probody therapeutic

Author

Etxeberria, Iñaki, Bolaños, Elixabet, Teijeira, Alvaro, Garasa, Saray, Yanguas, Alba, Azpilikueta, Arantza, Kavanaugh, William M., Vasiljeva, Olga, Belvin, Marcia, Howng, Bruce, Irving, Bryan, Tipton, Kimberly, West, James, Mei, Li, Korman, Alan J., Sega, Emanuela, Olivera, Irene, Cirella, Assunta, Ochoa, Maria C., Rodriguez, Maria E., Melero, Ana, Sanmamed, Miguel F., Engelhardt, John J., and Melero, Ignacio

Published
2021

6. Short-term cultured tumor fragments to study immunotherapy combinations based on CD137 (4-1BB) agonism.

Author

Eguren-Santamaría, Iñaki, Rodríguez, Inmaculada, Herrero-Martin, Claudia, Fernández de Piérola, Eva, Azpilikueta, Arantza, Sánchez-Gregorio, Sandra, Bolaños, Elixabet, Gomis, Gabriel, Molero-Glez, Paula, Chacón, Enrique, Mínguez, José Ángel, Chiva, Santiago, Diez-Caballero, Fernando, de Andrea, Carlos, Teijeira, Álvaro, Sanmamed, Miguel F., and Melero, Ignacio

Abstract

Biomarkers for cancer immunotherapy are an unmet medical need. The group of Daniela Thommen at the NKI recently reported on novel methodologies based on short-term cultures of patient-derived tumor fragments whose cytokine concentrations in the supernatants and activation markers on infiltrating T cells were associated with clinical response to PD-1 blockade. We set up a similar culture technology with tumor-derived fragments using mouse tumors transplanted into syngeneic immunocompetent mice to test an agonist anti-CD137 mAb and its combinations with anti-PD-1 and/or anti-TGF-β. Increases in IFNγ concentrations in the tissue culture supernatants were detected upon in-culture activation with the anti-CD137 and anti-PD-1 mAb combinations or concanavalin A as a positive control. No other cytokine from a wide array was informative of stimulation with these mAbs. Interestingly, increases in Ki67 and other activation markers were substantiated in lymphocytes from cell suspensions gathered at the end of 72 h cultures. In mice bearing bilateral tumors in which one was excised prior to in vivo anti-CD137 + anti-PD-1 treatment to perform the fragment culture evaluation, no association was found between IFNγ production from the fragments and the in vivo therapeutic outcome in the non-resected contralateral tumors. The experimental system permitted freezing and thawing of the fragments with similar functional outcomes. Using a series of patient-derived tumor fragments from excised solid malignancies, we showed IFNγ production in a fraction of the studied cases, that was conserved in frozen/thawed fragments. The small tumor fragment culture technique seems suitable to preclinically explore immunotherapy combinations. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

7. Complement C5a induces the formation of neutrophil extracellular traps by myeloid-derived suppressor cells to promote metastasis

Author

Ortiz-Espinosa, Sergio, Morales, Xabier, Senent, Yaiza, Alignani, Diego, Tavira, Beatriz, Macaya, Irati, Ruiz, Borja, Moreno, Haritz, Remírez, Ana, Sainz, Cristina, Rodriguez-Pena, Alejandro, Oyarbide, Alvaro, Ariz, Mikel, Andueza, Maria P., Valencia, Karmele, Teijeira, Alvaro, Hoehlig, Kai, Vater, Axel, Rolfe, Barbara, Woodruff, Trent M., Lopez-Picazo, Jose Maria, Vicent, Silvestre, Kochan, Grazyna, Escors, David, Gil-Bazo, Ignacio, Perez-Gracia, Jose Luis, Montuenga, Luis M., Lambris, John D., Ortiz de Solorzano, Carlos, Lecanda, Fernando, Ajona, Daniel, and Pio, Ruben

Published
2022
Full Text
View/download PDF

8. CXCR1 and CXCR2 Chemokine Receptor Agonists Produced by Tumors Induce Neutrophil Extracellular Traps that Interfere with Immune Cytotoxicity

Author

Teijeira, Álvaro, Garasa, Saray, Gato, María, Alfaro, Carlos, Migueliz, Itziar, Cirella, Assunta, de Andrea, Carlos, Ochoa, Maria Carmen, Otano, Itziar, Etxeberria, Iñaki, Andueza, Maria Pilar, Nieto, Celia P., Resano, Leyre, Azpilikueta, Arantza, Allegretti, Marcello, de Pizzol, Maria, Ponz-Sarvisé, Mariano, Rouzaut, Ana, Sanmamed, Miguel F., Schalper, Kurt, Carleton, Michael, Mellado, Mario, Rodriguez-Ruiz, María E., Berraondo, Pedro, Perez-Gracia, Jose L., and Melero, Ignacio

Published
2020
Full Text
View/download PDF

11. CD137 (4-1BB) costimulation of CD8+ T cells is more potent when provided in cis than in trans with respect to CD3-TCR stimulation

Author

Otano, Itziar, Azpilikueta, Arantza, Glez-Vaz, Javier, Alvarez, Maite, Medina-Echeverz, José, Cortés-Domínguez, Ivan, Ortiz-de-Solorzano, Carlos, Ellmark, Peter, Fritzell, Sara, Hernandez-Hoyos, Gabriela, Nelson, Michelle Hase, Ochoa, María Carmen, Bolaños, Elixabet, Cuculescu, Doina, Jaúregui, Patricia, Sanchez-Gregorio, Sandra, Etxeberria, Iñaki, Rodriguez-Ruiz, María E., Sanmamed, Miguel F., Teijeira, Álvaro, Berraondo, Pedro, and Melero, Ignacio

Published
2021
Full Text
View/download PDF

13. CD137 (4-1BB) requires physically associated cIAPs for signal transduction and antitumor effects

Author

Glez-Vaz, Javier, primary, Azpilikueta, Arantza, additional, Ochoa, María C., additional, Olivera, Irene, additional, Gomis, Gabriel, additional, Cirella, Asunta, additional, Luri-Rey, Carlos, additional, Álvarez, Maite, additional, Pérez-Gracia, Jose L., additional, Ciordia, Sergio, additional, Eguren-Santamaria, Iñaki, additional, Alexandru, Raluca, additional, Berraondo, Pedro, additional, de Andrea, Carlos, additional, Teijeira, Álvaro, additional, Corrales, Fernando, additional, Zapata, Juan M., additional, and Melero, Ignacio, additional

Published
2023
Full Text
View/download PDF

15. Supplementary Figure from A Therapeutically Actionable Protumoral Axis of Cytokines Involving IL-8, TNFα, and IL-1β

Author

Olivera, Irene, primary, Sanz-Pamplona, Rebeca, primary, Bolaños, Elixabet, primary, Rodriguez, Inmaculada, primary, Etxeberria, Iñaki, primary, Cirella, Assunta, primary, Egea, Josune, primary, Garasa, Saray, primary, Migueliz, Itziar, primary, Eguren-Santamaria, Iñaki, primary, Sanmamed, Miguel F., primary, Glez-Vaz, Javier, primary, Azpilikueta, Arantza, primary, Alvarez, Maite, primary, Ochoa, María C., primary, Malacrida, Beatrice, primary, Propper, David, primary, de Andrea, Carlos E., primary, Berraondo, Pedro, primary, Balkwill, Frances R., primary, Teijeira, Álvaro, primary, and Melero, Ignacio, primary

Published
2023
Full Text
View/download PDF

16. Data from Tumor ENPP1 (CD203a)/Haptoglobin Axis Exploits Myeloid-Derived Suppressor Cells to Promote Post-Radiotherapy Local Recurrence in Breast Cancer

Author

Ruiz-Fernández de Córdoba, Borja, primary, Moreno, Haritz, primary, Valencia, Karmele, primary, Perurena, Naiara, primary, Ruedas, Pablo, primary, Walle, Thomas, primary, Pezonaga-Torres, Alberto, primary, Hinojosa, Juan, primary, Guruceaga, Elisabet, primary, Pineda-Lucena, Antonio, primary, Abengózar-Muela, Marta, primary, Cochonneau, Denis, primary, Zandueta, Carolina, primary, Martínez-Canarias, Susana, primary, Teijeira, Álvaro, primary, Ajona, Daniel, primary, Ortiz-Espinosa, Sergio, primary, Morales, Xabier, primary, Ortiz de Solórzano, Carlos, primary, Santisteban, Marta, primary, Ramos-García, Luis I., primary, Guembe, Laura, primary, Strnad, Vratislav, primary, Heymann, Dominique, primary, Hervás-Stubbs, Sandra, primary, Pío, Rubén, primary, Rodríguez-Ruiz, María E., primary, de Andrea, Carlos E., primary, Vicent, Silvestre, primary, Melero, Ignacio, primary, Lecanda, Fernando, primary, and Martínez-Monge, Rafael, primary

Published
2023
Full Text
View/download PDF

17. Abstract 614: CD137 (4-1BB) requires physically associated cIAPs for signal transduction and antitumor effects

Author

Glez-Vaz, Javier, primary, Azpilikueta, Arantza, additional, Ochoa, Maria Carmen, additional, Olivera, Irene, additional, Gomis, Gabriel, additional, Cirella, Asunta, additional, Luri-Rey, Carlos, additional, Álvarez, Maite, additional, Ciordia, Sergio, additional, Berraondo, Pedro, additional, Teijeira, Álvaro, additional, Corrales, Fernando, additional, Zapata, Juan M, additional, and Melero, Ignacio, additional

Published
2023
Full Text
View/download PDF

18. Data from A Therapeutically Actionable Protumoral Axis of Cytokines Involving IL-8, TNFα, and IL-1β

Author

Olivera, Irene, primary, Sanz-Pamplona, Rebeca, primary, Bolaños, Elixabet, primary, Rodriguez, Inmaculada, primary, Etxeberria, Iñaki, primary, Cirella, Assunta, primary, Egea, Josune, primary, Garasa, Saray, primary, Migueliz, Itziar, primary, Eguren-Santamaria, Iñaki, primary, Sanmamed, Miguel F., primary, Glez-Vaz, Javier, primary, Azpilikueta, Arantza, primary, Alvarez, Maite, primary, Ochoa, María C., primary, Malacrida, Beatrice, primary, Propper, David, primary, de Andrea, Carlos E., primary, Berraondo, Pedro, primary, Balkwill, Frances R., primary, Teijeira, Álvaro, primary, and Melero, Ignacio, primary

Published
2023
Full Text
View/download PDF

19. Supplementary Data from Tumor ENPP1 (CD203a)/Haptoglobin Axis Exploits Myeloid-Derived Suppressor Cells to Promote Post-Radiotherapy Local Recurrence in Breast Cancer

Author

Ruiz-Fernández de Córdoba, Borja, primary, Moreno, Haritz, primary, Valencia, Karmele, primary, Perurena, Naiara, primary, Ruedas, Pablo, primary, Walle, Thomas, primary, Pezonaga-Torres, Alberto, primary, Hinojosa, Juan, primary, Guruceaga, Elisabet, primary, Pineda-Lucena, Antonio, primary, Abengózar-Muela, Marta, primary, Cochonneau, Denis, primary, Zandueta, Carolina, primary, Martínez-Canarias, Susana, primary, Teijeira, Álvaro, primary, Ajona, Daniel, primary, Ortiz-Espinosa, Sergio, primary, Morales, Xabier, primary, Ortiz de Solórzano, Carlos, primary, Santisteban, Marta, primary, Ramos-García, Luis I., primary, Guembe, Laura, primary, Strnad, Vratislav, primary, Heymann, Dominique, primary, Hervás-Stubbs, Sandra, primary, Pío, Rubén, primary, Rodríguez-Ruiz, María E., primary, de Andrea, Carlos E., primary, Vicent, Silvestre, primary, Melero, Ignacio, primary, Lecanda, Fernando, primary, and Martínez-Monge, Rafael, primary

Published
2023
Full Text
View/download PDF

20. Supplementary Figure from Tumor ENPP1 (CD203a)/Haptoglobin Axis Exploits Myeloid-Derived Suppressor Cells to Promote Post-Radiotherapy Local Recurrence in Breast Cancer

Author

Ruiz-Fernández de Córdoba, Borja, primary, Moreno, Haritz, primary, Valencia, Karmele, primary, Perurena, Naiara, primary, Ruedas, Pablo, primary, Walle, Thomas, primary, Pezonaga-Torres, Alberto, primary, Hinojosa, Juan, primary, Guruceaga, Elisabet, primary, Pineda-Lucena, Antonio, primary, Abengózar-Muela, Marta, primary, Cochonneau, Denis, primary, Zandueta, Carolina, primary, Martínez-Canarias, Susana, primary, Teijeira, Álvaro, primary, Ajona, Daniel, primary, Ortiz-Espinosa, Sergio, primary, Morales, Xabier, primary, Ortiz de Solórzano, Carlos, primary, Santisteban, Marta, primary, Ramos-García, Luis I., primary, Guembe, Laura, primary, Strnad, Vratislav, primary, Heymann, Dominique, primary, Hervás-Stubbs, Sandra, primary, Pío, Rubén, primary, Rodríguez-Ruiz, María E., primary, de Andrea, Carlos E., primary, Vicent, Silvestre, primary, Melero, Ignacio, primary, Lecanda, Fernando, primary, and Martínez-Monge, Rafael, primary

Published
2023
Full Text
View/download PDF

23. Supplementary figure 4 from Intratumoral Immunotherapy with XCL1 and sFlt3L Encoded in Recombinant Semliki Forest Virus–Derived Vectors Fosters Dendritic Cell–Mediated T-cell Cross-Priming

Author

Sánchez-Paulete, Alfonso R., primary, Teijeira, Álvaro, primary, Quetglas, José I., primary, Rodríguez-Ruiz, María E., primary, Sánchez-Arráez, Álvaro, primary, Labiano, Sara, primary, Etxeberria, Iñaki, primary, Azpilikueta, Arantza, primary, Bolaños, Elixabet, primary, Ballesteros-Briones, María Cristina, primary, Casares, Noelia, primary, Quezada, Sergio A., primary, Berraondo, Pedro, primary, Sancho, David, primary, Smerdou, Cristian, primary, and Melero, Ignacio, primary

Published
2023
Full Text
View/download PDF

24. Supplementary figure 7 from Intratumoral Immunotherapy with XCL1 and sFlt3L Encoded in Recombinant Semliki Forest Virus–Derived Vectors Fosters Dendritic Cell–Mediated T-cell Cross-Priming

Author

Sánchez-Paulete, Alfonso R., primary, Teijeira, Álvaro, primary, Quetglas, José I., primary, Rodríguez-Ruiz, María E., primary, Sánchez-Arráez, Álvaro, primary, Labiano, Sara, primary, Etxeberria, Iñaki, primary, Azpilikueta, Arantza, primary, Bolaños, Elixabet, primary, Ballesteros-Briones, María Cristina, primary, Casares, Noelia, primary, Quezada, Sergio A., primary, Berraondo, Pedro, primary, Sancho, David, primary, Smerdou, Cristian, primary, and Melero, Ignacio, primary

Published
2023
Full Text
View/download PDF

25. Supplementary figure 1 from Intratumoral Immunotherapy with XCL1 and sFlt3L Encoded in Recombinant Semliki Forest Virus–Derived Vectors Fosters Dendritic Cell–Mediated T-cell Cross-Priming

Author

Sánchez-Paulete, Alfonso R., primary, Teijeira, Álvaro, primary, Quetglas, José I., primary, Rodríguez-Ruiz, María E., primary, Sánchez-Arráez, Álvaro, primary, Labiano, Sara, primary, Etxeberria, Iñaki, primary, Azpilikueta, Arantza, primary, Bolaños, Elixabet, primary, Ballesteros-Briones, María Cristina, primary, Casares, Noelia, primary, Quezada, Sergio A., primary, Berraondo, Pedro, primary, Sancho, David, primary, Smerdou, Cristian, primary, and Melero, Ignacio, primary

Published
2023
Full Text
View/download PDF

26. Supplementary figure 5 from Intratumoral Immunotherapy with XCL1 and sFlt3L Encoded in Recombinant Semliki Forest Virus–Derived Vectors Fosters Dendritic Cell–Mediated T-cell Cross-Priming

Author

Sánchez-Paulete, Alfonso R., primary, Teijeira, Álvaro, primary, Quetglas, José I., primary, Rodríguez-Ruiz, María E., primary, Sánchez-Arráez, Álvaro, primary, Labiano, Sara, primary, Etxeberria, Iñaki, primary, Azpilikueta, Arantza, primary, Bolaños, Elixabet, primary, Ballesteros-Briones, María Cristina, primary, Casares, Noelia, primary, Quezada, Sergio A., primary, Berraondo, Pedro, primary, Sancho, David, primary, Smerdou, Cristian, primary, and Melero, Ignacio, primary

Published
2023
Full Text
View/download PDF

27. Sypplementary materials and methods from Intratumoral Immunotherapy with XCL1 and sFlt3L Encoded in Recombinant Semliki Forest Virus–Derived Vectors Fosters Dendritic Cell–Mediated T-cell Cross-Priming

Author

Sánchez-Paulete, Alfonso R., primary, Teijeira, Álvaro, primary, Quetglas, José I., primary, Rodríguez-Ruiz, María E., primary, Sánchez-Arráez, Álvaro, primary, Labiano, Sara, primary, Etxeberria, Iñaki, primary, Azpilikueta, Arantza, primary, Bolaños, Elixabet, primary, Ballesteros-Briones, María Cristina, primary, Casares, Noelia, primary, Quezada, Sergio A., primary, Berraondo, Pedro, primary, Sancho, David, primary, Smerdou, Cristian, primary, and Melero, Ignacio, primary

Published
2023
Full Text
View/download PDF

28. Data from Intratumoral Immunotherapy with XCL1 and sFlt3L Encoded in Recombinant Semliki Forest Virus–Derived Vectors Fosters Dendritic Cell–Mediated T-cell Cross-Priming

Author

Sánchez-Paulete, Alfonso R., primary, Teijeira, Álvaro, primary, Quetglas, José I., primary, Rodríguez-Ruiz, María E., primary, Sánchez-Arráez, Álvaro, primary, Labiano, Sara, primary, Etxeberria, Iñaki, primary, Azpilikueta, Arantza, primary, Bolaños, Elixabet, primary, Ballesteros-Briones, María Cristina, primary, Casares, Noelia, primary, Quezada, Sergio A., primary, Berraondo, Pedro, primary, Sancho, David, primary, Smerdou, Cristian, primary, and Melero, Ignacio, primary

Published
2023
Full Text
View/download PDF

29. Supplementary figure 3 from Intratumoral Immunotherapy with XCL1 and sFlt3L Encoded in Recombinant Semliki Forest Virus–Derived Vectors Fosters Dendritic Cell–Mediated T-cell Cross-Priming

Author

Sánchez-Paulete, Alfonso R., primary, Teijeira, Álvaro, primary, Quetglas, José I., primary, Rodríguez-Ruiz, María E., primary, Sánchez-Arráez, Álvaro, primary, Labiano, Sara, primary, Etxeberria, Iñaki, primary, Azpilikueta, Arantza, primary, Bolaños, Elixabet, primary, Ballesteros-Briones, María Cristina, primary, Casares, Noelia, primary, Quezada, Sergio A., primary, Berraondo, Pedro, primary, Sancho, David, primary, Smerdou, Cristian, primary, and Melero, Ignacio, primary

Published
2023
Full Text
View/download PDF

30. Supplementary figure 2 from Intratumoral Immunotherapy with XCL1 and sFlt3L Encoded in Recombinant Semliki Forest Virus–Derived Vectors Fosters Dendritic Cell–Mediated T-cell Cross-Priming

Author

Sánchez-Paulete, Alfonso R., primary, Teijeira, Álvaro, primary, Quetglas, José I., primary, Rodríguez-Ruiz, María E., primary, Sánchez-Arráez, Álvaro, primary, Labiano, Sara, primary, Etxeberria, Iñaki, primary, Azpilikueta, Arantza, primary, Bolaños, Elixabet, primary, Ballesteros-Briones, María Cristina, primary, Casares, Noelia, primary, Quezada, Sergio A., primary, Berraondo, Pedro, primary, Sancho, David, primary, Smerdou, Cristian, primary, and Melero, Ignacio, primary

Published
2023
Full Text
View/download PDF

31. supplementary figure 6 from Intratumoral Immunotherapy with XCL1 and sFlt3L Encoded in Recombinant Semliki Forest Virus–Derived Vectors Fosters Dendritic Cell–Mediated T-cell Cross-Priming

Author

Sánchez-Paulete, Alfonso R., primary, Teijeira, Álvaro, primary, Quetglas, José I., primary, Rodríguez-Ruiz, María E., primary, Sánchez-Arráez, Álvaro, primary, Labiano, Sara, primary, Etxeberria, Iñaki, primary, Azpilikueta, Arantza, primary, Bolaños, Elixabet, primary, Ballesteros-Briones, María Cristina, primary, Casares, Noelia, primary, Quezada, Sergio A., primary, Berraondo, Pedro, primary, Sancho, David, primary, Smerdou, Cristian, primary, and Melero, Ignacio, primary

Published
2023
Full Text
View/download PDF

33. Intracavitary adoptive transfer of IL-12 mRNA-engineered tumor-specific CD8+ T cells eradicates peritoneal metastases in mouse models

Author

Di Trani, Claudia Augusta, primary, Cirella, Assunta, additional, Arrizabalaga, Leire, additional, Bella, Ángela, additional, Fernandez-Sendin, Myriam, additional, Russo-Cabrera, Joan Salvador, additional, Gomar, Celia, additional, Olivera, Irene, additional, Bolaños, Elizabeth, additional, González-Gomariz, José, additional, Álvarez, Maite, additional, Etxeberria, Iñaki, additional, Palencia, Belen, additional, Teijeira, Álvaro, additional, Melero, Ignacio, additional, Berraondo, Pedro, additional, and Aranda, Fernando, additional

Published
2022
Full Text
View/download PDF

34. DSTYK inhibition increases the sensitivity of lung cancer cells to T cell–mediated cytotoxicity

Author

Valencia, Karmele, primary, Echepare, Mirari, additional, Teijeira, Álvaro, additional, Pasquier, Andrea, additional, Bértolo, Cristina, additional, Sainz, Cristina, additional, Tamayo, Ibon, additional, Picabea, Beñat, additional, Bosco, Graziella, additional, Thomas, Roman, additional, Agorreta, Jackeline, additional, López-Picazo, José María, additional, Frigola, Joan, additional, Amat, Ramon, additional, Calvo, Alfonso, additional, Felip, Enriqueta, additional, Melero, Ignacio, additional, and Montuenga, Luis M., additional

Published
2022
Full Text
View/download PDF

35. Synergistic antitumor response with recombinant modified virus Ankara armed with CD40L and CD137L against peritoneal carcinomatosis

Author

Bella, Ángela, primary, Arrizabalaga, Leire, additional, Di Trani, Claudia Augusta, additional, Cirella, Assunta, additional, Fernandez-Sendin, Myriam, additional, Gomar, Celia, additional, Russo-Cabrera, Joan Salvador, additional, Rodríguez, Inmaculada, additional, González-Gomariz, José, additional, Alvarez, Maite, additional, Teijeira, Álvaro, additional, Medina-Echeverz, José, additional, Hinterberger, Maria, additional, Hochrein, Hubertus, additional, Melero, Ignacio, additional, Berraondo, Pedro, additional, and Aranda, Fernando, additional

Published
2022
Full Text
View/download PDF

37. A Therapeutically Actionable Protumoral Axis of Cytokines Involving IL-8, TNFα, and IL-1β

Author

Olivera, Irene, primary, Sanz-Pamplona, Rebeca, additional, Bolaños, Elixabet, additional, Rodriguez, Inmaculada, additional, Etxeberria, Iñaki, additional, Cirella, Assunta, additional, Egea, Josune, additional, Garasa, Saray, additional, Migueliz, Itziar, additional, Eguren-Santamaria, Iñaki, additional, Sanmamed, Miguel F., additional, Glez-Vaz, Javier, additional, Azpilikueta, Arantza, additional, Alvarez, Maite, additional, Ochoa, María C., additional, Malacrida, Beatrice, additional, Propper, David, additional, de Andrea, Carlos E., additional, Berraondo, Pedro, additional, Balkwill, Frances R., additional, Teijeira, Álvaro, additional, and Melero, Ignacio, additional

Published
2022
Full Text
View/download PDF

38. Abstract 3826: A therapeutically actionable pro-tumoral axis of cytokines involving interleukin-8, TNFα and IL-1β

Author

Olivera, Irene, primary, Sanz-Pamplona, Rebeca, additional, Bolaños, Elixabet, additional, Rodriguez, Inmaculada, additional, Etxeberria, Iñaki, additional, Cirella, Assunta, additional, Garasa, Saray, additional, Migueliz, Itziar, additional, Eguren, Iñaki, additional, Sanmamed, Miguel F., additional, Glez-Vaz, Javier, additional, Azpilikueta, Arantza, additional, Alvarez, Maite, additional, Ochoa, Maria C., additional, De Andrea, Carlos E., additional, Berraondo, Pedro, additional, Teijeira, Álvaro, additional, and Melero, Ignacio, additional

Published
2022
Full Text
View/download PDF

41. Tumor ENPP1 (CD203a)/Haptoglobin Axis Exploits Myeloid-Derived Suppressor Cells to Promote Post-Radiotherapy Local Recurrence in Breast Cancer

Author

Ruiz-Fernández de Córdoba, Borja, primary, Moreno, Haritz, additional, Valencia, Karmele, additional, Perurena, Naiara, additional, Ruedas, Pablo, additional, Walle, Thomas, additional, Pezonaga-Torres, Alberto, additional, Hinojosa, Juan, additional, Guruceaga, Elisabet, additional, Pineda-Lucena, Antonio, additional, Abengózar-Muela, Marta, additional, Cochonneau, Denis, additional, Zandueta, Carolina, additional, Martínez-Canarias, Susana, additional, Teijeira, Álvaro, additional, Ajona, Daniel, additional, Ortiz-Espinosa, Sergio, additional, Morales, Xabier, additional, Ortiz de Solórzano, Carlos, additional, Santisteban, Marta, additional, Ramos-García, Luis I., additional, Guembe, Laura, additional, Strnad, Vratislav, additional, Heymann, Dominique, additional, Hervás-Stubbs, Sandra, additional, Pío, Rubén, additional, Rodríguez-Ruiz, María E., additional, de Andrea, Carlos E., additional, Vicent, Silvestre, additional, Melero, Ignacio, additional, Lecanda, Fernando, additional, and Martínez-Monge, Rafael, additional

Published
2022
Full Text
View/download PDF

42. Intracavitary adoptive transfer of IL-12 mRNA-engineered tumor-specific CD8+ T cells eradicates peritoneal metastases in mouse models.

Author

Di Trani, Claudia Augusta, Cirella, Assunta, Arrizabalaga, Leire, Bella, Ángela, Fernandez-Sendin, Myriam, Russo-Cabrera, Joan Salvador, Gomar, Celia, Olivera, Irene, Bolaños, Elizabeth, González-Gomariz, José, Álvarez, Maite, Etxeberria, Iñaki, Palencia, Belen, Teijeira, Álvaro, Melero, Ignacio, Berraondo, Pedro, and Aranda, Fernando

Subjects
T cells, TUMOR antigens, LABORATORY mice, CANCER invasiveness, PERITONEUM, PERITONEAL cancer
Abstract

Previous studies have shown that local delivery of tumor antigen-specific CD8+ T lymphocytes engineered to transiently express single-chain IL-12 mRNA is highly efficacious. Peritoneal dissemination of cancer is a frequent and often fatal patient condition usually diagnosed when the tumor burden is too large and hence uncontrollable with current treatment options. In this study, we have modeled intracavitary adoptive T cell therapy with OVA-specific OT-I T cells electroporated with IL-12 mRNA to treat B16-OVA and PANC02-OVA tumor spread in the peritoneal cavity. Tumor localization in the omentum and the effects of local T-cell encounter with the tumor antigens were monitored, the gene expression profile evaluated, and the phenotypic reprogramming of several immune subsets was characterized. Intraperitoneal administration of T cells promoted homing to the omentum more effectively than intravenous administration. Transient IL-12 expression was responsible for a favorable reprogramming of the tumor immune microenvironment, longer persistence of transferred T lymphocytes in vivo, and the development of immunity to endogenous antigens following primary tumor eradication. The efficacy of the strategy was at least in part recapitulated with the adoptive transfer of lower affinity transgenic TCR-bearing PMEL-1 T lymphocytes to treat the aggressive intraperitoneally disseminated B16-F10 tumor. Locoregional adoptive transfer of transiently IL-12-armored T cells appears to offer promising therapeutic advantages in terms of anti-tumor efficacy to treat peritoneal carcinomatosis. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

44. Heterogenous presence of neutrophil extracellular traps in human solid tumours is partially dependent on IL ‐8

Author

de Andrea, Carlos E, primary, Ochoa, María Carmen, additional, Villalba‐Esparza, María, additional, Teijeira, Álvaro, additional, Schalper, Kurt A, additional, Abengozar‐Muela, Marta, additional, Eguren‐Santamaría, Iñaki, additional, Sainz, Cristina, additional, Sánchez‐Gregorio, Sandra, additional, Garasa, Saray, additional, Ariz, Mikel, additional, Ortiz‐de‐Solorzano, Carlos, additional, Rodriguez‐Ruiz, María E, additional, Perez‐Gracia, Jose L, additional, Lozano, María D, additional, Echeveste, José I, additional, Sanmamed, Miguel F, additional, and Melero, Ignacio, additional

Published
2021
Full Text
View/download PDF

45. Neutrophil Extracellular Traps, Local IL-8 Expression, and Cytotoxic T-Lymphocyte Absence in the Lungs of Fatal COVID-19: A Retrospective Histopathology Cohort Study

Author

Laura Álvarez-Gigli, Manu Landecho, Amy Cross, María Villalba-Esparza, Laura García-Tobar, Jorge Quiroga, Allan Argueta, Teijeira Álvaro, Estefanía Toledo, Maria Rodriguez-Moreno, Gabriel Reina, Ignacio Melero, Carlos E. de Andrea, Marta Abengozar-Muela, Ling-Pei Ho, Mirian Fernández-Alonso, Cristina Sainz, Francisco Carmona-Torre, Borja Recalde-Zamacona, José I. Echeveste, Paul Klenerman, Fadi Issa, David Garcia-Ros, José Luis del Pozo, and Maria D. Lozano

Subjects
History, medicine.medical_specialty, Chemokine, Lung, Polymers and Plastics, biology, business.industry, Inflammation, Neutrophil extracellular traps, medicine.disease, Industrial and Manufacturing Engineering, medicine.anatomical_structure, Immunology, medicine, biology.protein, Histopathology, Business and International Management, medicine.symptom, business, Viral load, CD8, Pneumonitis
Abstract

Background: Excessive inflammation is pathogenic in pneumonitis associated to severe COVID-19. Neutrophils are among the most abundantly present leukocytes in the inflammatory infiltrates and may form neutrophil extracellular traps (NETs) under the local influence of cytokines. NETs constitute a defence mechanism against bacteria but have also been shown to mediate tissue damage in a number of diseases. Methods: In this retrospective cohort study, sixteen immediate post-mortem lung biopsies were methodologically analysed as exploratory and validation cohorts. NETs were quantitatively analysed by multiplexed immunofluorescence and correlated with local levels of IL-8 mRNA expression and the density of CD8+ T-cell infiltration. SARS-CoV-2 presence in tissue was quantified by RT-PCR and immunohistochemistry. Findings: NETs were found in the lung interstitium and surrounding the bronchiolar epithelium with interindividual and spatial heterogeneity. NET density did not correlate with SARS-CoV-2 tissue viral load. NETs were associated with local IL-8 mRNA levels. NETs were also detected in pulmonary thrombi and in only one out of eight liver tissues in spatial fashion. NET focal presence negatively correlated with CD8+ T-cell infiltration in the lungs. Interpretation: Abundant neutrophils undergoing NETosis are found in the lungs of patients with fatal COVID-19, showing no correlation with viral loads. The strong association between NETs and IL-8 focal expression points to this chemokine as the potential causative factor. The function of cytotoxic T-lymphocytes in the immune responses against SARS-CoV-2 may be interfered by the presence of NETs. Funding Information: This study was supported by Banco Bilbao Vizcaya (BBVA) Foundation, “Ayudas a Equipos de Investigacion Cientifica SARS-CoV-2 y COVID-19”. Declaration of Interests: I.M. reports receiving commercial research grants from BMS, Bioncotech, Alligator, Pfizer, Leadartis and Roche; has received speakers bureau honoraria from MSD; and is a consultant or advisory board member for BMS, Roche, Genmab, F-Star, Bioncotech, Bayer, Numab, Pieris, Alligator, and Merck Serono. C.E.A reports research grants from AstraZeneca. All other authors declare no competing interests. Ethics Approval Statement: This study was approved by the ethics committee of the University of Navarra, Spain (Approval 2020.192). Tissue collections were obtained with consent from a first-degree relative, following a protocol approved by the ethics committee of the University of Navarra (Protocol 2020.192p).

Published
2021
Full Text
View/download PDF

46. Mouse Models of Peritoneal Carcinomatosis to Develop Clinical Applications

Author

Bella, Ángela, primary, Di Trani, Claudia Augusta, additional, Fernández-Sendin, Myriam, additional, Arrizabalaga, Leire, additional, Cirella, Assunta, additional, Teijeira, Álvaro, additional, Medina-Echeverz, José, additional, Melero, Ignacio, additional, Berraondo, Pedro, additional, and Aranda, Fernando, additional

Published
2021
Full Text
View/download PDF

48. Human CD8 T cells are susceptible to TNF-mediated activation-induced cell death

Author

Otano, Itziar, primary, Alvarez, Maite, additional, Minute, Luna, additional, Ochoa, María Carmen, additional, Migueliz, Itziar, additional, Molina, Carmen, additional, Azpilikueta, Arantza, additional, de Andrea, Carlos E., additional, Etxeberria, Iñaki, additional, Sanmamed, Miguel F., additional, Teijeira, Álvaro, additional, Berraondo, Pedro, additional, and Melero, Ignacio, additional

Published
2020
Full Text
View/download PDF

50. CD137 (4-1BB) costimulation of CD8+ T cells is more potent when provided in cis than in trans with respect to CD3-TCR stimulation.

Author

Otano, Itziar, Azpilikueta, Arantza, Glez-Vaz, Javier, Alvarez, Maite, Medina-Echeverz, José, Cortés-Domínguez, Ivan, Ortiz-de-Solorzano, Carlos, Ellmark, Peter, Fritzell, Sara, Hernandez-Hoyos, Gabriela, Nelson, Michelle Hase, Ochoa, María Carmen, Bolaños, Elixabet, Cuculescu, Doina, Jaúregui, Patricia, Sanchez-Gregorio, Sandra, Etxeberria, Iñaki, Rodriguez-Ruiz, María E., Sanmamed, Miguel F., and Teijeira, Álvaro

Subjects
CELL survival, IMMUNE response, CELL cycle, DNA repair, DNA damage, T cells, INTERLEUKIN-7
Abstract

CD137 (4-1BB; TNFSR9) is an activation-induced surface receptor that through costimulation effects provide antigen-primed T cells with augmented survival, proliferation and effector functions as well as metabolic advantages. These immunobiological mechanisms are being utilised for cancer immunotherapy with agonist CD137-binding and crosslinking-inducing agents that elicit CD137 intracellular signaling. In this study, side-by-side comparisons show that provision of CD137 costimulation in-cis with regard to the TCR-CD3-ligating cell is superior to that provided in-trans in terms of T cell activation, proliferation, survival, cytokine secretion and mitochondrial fitness in mouse and human. Cis ligation of CD137 relative to the TCR-CD3 complex results in more intense canonical and non-canonical NF-κB signaling and provides a more robust induction of cell cycle and DNA damage repair gene expression programs. Here we report that the superiority of cis versus trans CD137-costimulation is readily observed in vivo and is relevant for understanding the immunotherapeutic effects of CAR T cells and CD137 agonistic therapies currently undergoing clinical trials, which may provide costimulation either in cis or in trans. Costimulation has been shown to be required for optimal activation of T cells and it could be delivered either in trans with respect to the source of CD3-TCR ligation or in cis on the same cell. Here the authors show that CD137 costimulation is more effective when delivered in cis to enhance T cell proliferation and activation. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results