Search

Your search keyword '"Teichmann, Martina"' showing total 11 results
Start Over Author "Teichmann, Martina"
11 results on '"Teichmann, Martina"'

1. Comprehensive mutational profiling in advanced systemic mastocytosis

Author

Schwaab, Juliana, Schnittger, Susanne, Sotlar, Karl, Walz, Christoph, Fabarius, Alice, Pfirrmann, Markus, Kohlmann, Alexander, Grossmann, Vera, Meggendorfer, Manja, Horny, Hans-Peter, Valent, Peter, Jawhar, Mohamad, Teichmann, Martina, Metzgeroth, Georgia, Erben, Philipp, Ernst, Thomas, Hochhaus, Andreas, Haferlach, Torsten, Hofmann, Wolf-Karsten, Cross, Nicholas C.P., and Reiter, Andreas

Published
2013
Full Text
View/download PDF

3. Impact of PTPN11 mutations on clinical outcome analyzed in 1529 patients with acute myeloid leukemia

Author

Stasik, Sebastian, Eckardt, Jan-Niklas, Kramer, Michael, Röllig, Christoph, Krämer, Alwin, Scholl, Sebastian, Hochhaus, Andreas, Crysandt, Martina, Brümmendorf, Tim H., Naumann, Ralph, Steffen, Björn, Kunzmann, Volker, Einsele, Hermann, Schaich, Markus, Burchert, Andreas, Neubauer, Andreas, Schäfer-Eckart, Kerstin, Schliemann, Christoph, Krause, Stefan, Herbst, Regina, Hänel, Mathias, Frickhofen, Norbert, Noppeney, Richard, Kaiser, Ulrich, Baldus, Claudia D., Kaufmann, Martin, Rácil, Zdenek, Platzbecker, Uwe, Berdel, Wolfgang E., Mayer, Jiri, Serve, Hubert, Müller-Tidow, Carsten, Ehninger, Gerhard, Bornhäuser, Martin, Schetelig, Johannes, Middeke, Jan M., Thiede, Christian, Schulz-Abelius, Armin, Trepel, Martin, Teichmann, Martina, Kiani, Alexander, Glaß, Bertram, Görner, Martin, Behringer, Dirk, Kullmer, Johannes, Lamberti, Christof, Schmidt-Hieber, Martin, Flaßhove, Michael, MacKensen, Andreas, Hanoun, Maher, Kiehl, Michael, Höffkes, H.-G., Müller, Lutz Peter, Dürk, Heinz Albert, Held, Gerhard, Repp, Roland Peter, Baldus, Claudia, Chemnitz, Jens-Marcus, Klein, Stefan, Wilhelm, Martin, Schubert, Jörg, Meinhardt, Achim, Geer, Thomas, Ritter, Markus, Aulitzky, Walter Erich, and Heinz, Natalia

Subjects
Neuroblastoma RAS viral oncogene homolog, Oncology, musculoskeletal diseases, medicine.medical_specialty, NPM1, congenital, hereditary, and neonatal diseases and abnormalities, Medizin, Protein Tyrosine Phosphatase, Non-Receptor Type 11, Context (language use), 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Phosphoprotein Phosphatases, medicine, Humans, skin and connective tissue diseases, 030304 developmental biology, 0303 health sciences, Myeloid Neoplasia, business.industry, Remission Induction, Hazard ratio, Cytogenetics, Myeloid leukemia, Hematology, Odds ratio, Prognosis, 3. Good health, PTPN11, Leukemia, Myeloid, Acute, 030220 oncology & carcinogenesis, Mutation, business, Nucleophosmin
Abstract

The tyrosine-protein phosphatase nonreceptor type 11 (PTPN11) is an important regulator of RAS signaling and frequently affected by mutations in patients with acute myeloid leukemia (AML). Despite the relevance for leukemogenesis and as a potential therapeutic target, the prognostic role is controversial. To investigate the prognostic impact of PTPN11 mutations, we analyzed 1529 adult AML patients using next-generation sequencing. PTPN11 mutations were detected in 106 of 1529 (6.93%) patients (median VAF: 24%) in dominant (36%) and subclonal (64%) configuration. Patients with PTPN11 mutations were associated with concomitant mutations in NPM1 (63%), DNMT3A (37%), and NRAS (21%) and had a higher rate of European LeukemiaNet (ELN) favorable cytogenetics (57.8% vs 39.1%; P < .001) and higher white blood cell counts (P = .007) compared with PTPN11 wild-type patients. In a multivariable analysis, PTPN11 mutations were independently associated with poor overall survival (hazard ratio [HR]: 1.75; P < .001), relapse-free survival (HR: 1.52; P = .013), and a lower rate of complete remission (odds ratio: 0.46; P = .008). Importantly, the deleterious effect of PTPN11 mutations was confined predominantly to the ELN favorable-risk group and patients with subclonal PTPN11 mutations (HR: 2.28; P < .001) but not found with dominant PTPN11 mutations (HR: 1.07; P = .775), presumably because of significant differences within the rate and spectrum of associated comutations. In conclusion, our data suggest an overall poor prognostic impact of PTPN11 mutations in AML, which is significantly modified by the underlying cytogenetics and the clonal context in which they occur.

Published
2021

4. The KIT D816V expressed allele burden for diagnosis and disease monitoring of systemic mastocytosis

Author

Erben, Philipp, primary, Schwaab, Juliana, additional, Metzgeroth, Georgia, additional, Horny, Hans-Peter, additional, Jawhar, Mohamad, additional, Sotlar, Karl, additional, Fabarius, Alice, additional, Teichmann, Martina, additional, Schneider, Sven, additional, Ernst, Thomas, additional, Müller, Martin C., additional, Giehl, Michelle, additional, Marx, Alexander, additional, Hartmann, Karin, additional, Hochhaus, Andreas, additional, Hofmann, Wolf-Karsten, additional, Cross, Nicholas C. P., additional, and Reiter, Andreas, additional

Published
2013
Full Text
View/download PDF

5. Mutational Complexity Is Related To Disease Severity In Systemic Mastocytosis

Author

Schwaab, Juliana, primary, Schnittger, Susanne, additional, Sotlar, Karl, additional, Walz, Christoph, additional, Fabarius, Alice, additional, Pfirrmann, Markus, additional, Kohlmann, Alexander, additional, Grossmann, Vera, additional, Meggendorfer, Manja, additional, Horny, Hans Peter, additional, Valent, Peter, additional, Jawhar, Mohamad, additional, Teichmann, Martina, additional, Metzgeroth, Georgia, additional, Erben, Philipp, additional, Ernst, Thomas, additional, Hochhaus, Andreas, additional, Haferlach, Torsten, additional, Hofmann, Wolf-Karsten, additional, Cross, Nicholas C.P., additional, and Reiter, Andreas, additional

Published
2013
Full Text
View/download PDF

6. The KIT D816V Allele Burden in Systemic Mastocytosis Is Strongly Associated with Disease Subtype.

Author

Schwaab, Juliana, Erben, Philipp, Horny, Hans-Peter, Teichmann, Martina, Metzgeroth, Georgia, Ernst, Thomas, Sotlar, Karl, Mueller, Martin C., Marx, Alexander, Hartmann, Karin, Hochhaus, Andreas, Cross, Nicholas C. P., Hofmann, Wolf Karsten, Reiter, Andreas, Schwaab, Juliana, Erben, Philipp, Horny, Hans-Peter, Teichmann, Martina, Metzgeroth, Georgia, Ernst, Thomas, Sotlar, Karl, Mueller, Martin C., Marx, Alexander, Hartmann, Karin, Hochhaus, Andreas, Cross, Nicholas C. P., Hofmann, Wolf Karsten, and Reiter, Andreas

Published
2012

7. The KIT D816V Allele Burden in Systemic Mastocytosis Is Strongly Associated with Disease Subtype.

Author

Schwaab, Juliana, primary, Erben, Philipp, additional, Horny, Hans-Peter, additional, Teichmann, Martina, additional, Metzgeroth, Georgia, additional, Ernst, Thomas, additional, Sotlar, Karl, additional, Mueller, Martin C, additional, Marx, Alexander, additional, Hartmann, Karin, additional, Hochhaus, Andreas, additional, Cross, Nicholas C.P., additional, Hofmann, Wolf Karsten, additional, and Reiter, Andreas, additional

Published
2012
Full Text
View/download PDF

8. Critical Evaluation of Diverse Clinical, Laboratory, Radiological and Histological Parameters Indicating Gastrointestinal Involvement for Diagnosis of Indolent and Aggressive Systemic Mastocytosis

Author

Metzgeroth, Georgia, primary, Schwaab, Juliana, additional, Teichmann, Martina, additional, Marx, Alexander, additional, Michaely, Henrik J., additional, Horny, Hans Peter, additional, Cross, Nicholas C.P., additional, Hochhaus, Andreas, additional, Hofmann, Wolf Karsten, additional, and Reiter, Andreas, additional

Published
2011
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results