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150 results on '"Teepen, Jop C."'

1. The impact of clinically relevant health conditions on psychosocial outcomes in survivors of childhood cancer: results of the DCCSS-LATER study

Author

Maas, Anne, Maurice-Stam, Heleen, Feijen, Lieke E.A.M., Teepen, Jop C., van der Aa-van Delden, Alied M., Streefkerk, Nina, van Dulmen-den Broeder, Eline, Tissing, Wim J. E., Loonen, Jacqueline J., van der Pal, Helena J. H., de Vries, Andrica C. H., van den Heuvel-Eibrink, Marry M., Ronckers, Cécile, Neggers, Sebastian, Bresters, Dorine, Louwerens, Marloes, Versluys, Birgitta A. B., van der Heiden-van der Loo, Margriet, Kremer, Leontien C. M., and Grootenhuis, Martha

Published
2024
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2. Risk of subsequent gliomas and meningiomas among 69,460 5-year survivors of childhood and adolescent cancer in Europe: the PanCareSurFup study

Author

Heymer, Emma J., Hawkins, Michael M., Winter, David L., Teepen, Jop C., Sunguc, Ceren, Ronckers, Cécile M., Allodji, Rodrigue S., Alessi, Daniela, Sugden, Elaine, Belle, Fabiën N., Bagnasco, Francesca, Byrne, Julianne, Bárdi, Edit, Garwicz, Stanislaw, Grabow, Desiree, Jankovic, Momcilo, Kaatsch, Peter, Kaiser, Melanie, Michel, Gisela, Schindera, Christina, Haddy, Nadia, Journy, Neige, Česen Mazić, Maja, Skinner, Roderick, Kok, Judith L., Gunnes, Maria W., Wiebe, Thomas, Sacerdote, Carlotta, Maule, Milena M., Terenziani, Monica, Jakab, Zsuzsanna, Winther, Jeanette F., Lähteenmäki, Päivi M., Zadravec Zaletel, Lorna, Haupt, Riccardo, Kuehni, Claudia E., Kremer, Leontien C., de Vathaire, Florent, Hjorth, Lars, and Reulen, Raoul C.

Published
2024
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3. Increased risk of subsequent neoplasm after hematopoietic stem cell transplantation in 5-year survivors of childhood acute lymphoblastic leukemia

Author

Westerveld, Aimée S. R., Roesthuis, Pien, van der Pal, Helena J. H., Bresters, Dorine, Bierings, Marc, Loonen, Jacqueline, de Vries, Andrica C. H., Louwerens, Marloes, Koopman, Maria M. W., van den Heuvel-Eibrink, Marry M., van der Heiden-van der Loo, Margriet, Hoogerbrugge, Peter, Janssens, Geert O., de Krijger, Ronald R., Ronckers, Cecile M., Pieters, Rob, Kremer, Leontien C. M., and Teepen, Jop C.

Published
2024
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4. Subsequent female breast cancer risk associated with anthracycline chemotherapy for childhood cancer

Author

Wang, Yuehan, Ronckers, Cécile M., van Leeuwen, Flora E., Moskowitz, Chaya S., Leisenring, Wendy, Armstrong, Gregory T., de Vathaire, Florent, Hudson, Melissa M., Kuehni, Claudia E., Arnold, Michael A., Demoor-Goldschmidt, Charlotte, Green, Daniel M., Henderson, Tara O., Howell, Rebecca M., Ehrhardt, Matthew J., Neglia, Joseph P., Oeffinger, Kevin C., van der Pal, Helena J. H., Robison, Leslie L., Schaapveld, Michael, Turcotte, Lucie M., Waespe, Nicolas, Kremer, Leontien C. M., and Teepen, Jop C.

Published
2023
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5. Risk of subsequent primary oral cancer in a cohort of 69,460 5-year survivors of childhood and adolescent cancer in Europe: the PanCareSurFup study

Author

Sunguc, Ceren, Hawkins, Michael M., Winter, David L., Dudley, Isabelle M., Heymer, Emma J., Teepen, Jop C., Allodji, Rodrigue S., Belle, Fabiën N., Bagnasco, Francesca, Byrne, Julianne, Bárdi, Edit, Ronckers, Cécile M., Haddy, Nadia, Gudmundsdottir, Thorgerdur, Garwicz, Stanislaw, Jankovic, Momcilo, van der Pal, Helena J. H., Mazić, Maja Česen, Schindera, Christina, Grabow, Desiree, Maule, Milena M., Kaatsch, Peter, Kaiser, Melanie, Fresneau, Brice, Michel, Gisela, Skinner, Roderick, Wiebe, Thomas, Sacerdote, Carlotta, Jakab, Zsuzsanna, Gunnes, Maria Winther, Terenziani, Monica, Winther, Jeanette F., Lähteenmäki, Päivi M., Zaletel, Lorna Zadravec, Kuehni, Claudia E., Kremer, Leontien C., Haupt, Riccardo, de Vathaire, Florent, Hjorth, Lars, and Reulen, Raoul C.

Published
2023
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6. Extensive Cardiac Function Analyses Using Contemporary Echocardiography in Childhood Cancer Survivors: A DCCSS LATER Study

Author

Merkx, Remy, Leerink, Jan M., Feijen, E. (Lieke) A.M., de Baat, Esmée C., Bellersen, Louise, Bresters, Dorine, van Dalen, Elvira C., van Dulmen-den Broeder, Eline, van der Heiden-van der Loo, Margriet, van den Heuvel-Eibrink, Marry M., Kok, Judith L., Louwerens, Marloes, Maas, Angela H.E.M., Neggers, Sebastian J.C.M.M., Ronckers, Cécile M., Teepen, Jop C., Teske, Arco J., Tissing, Wim J.E., de Vries, Andrica C.H., Weijers, Gert, de Korte, Chris L., Loonen, Jacqueline, Mavinkurve-Groothuis, Annelies M.C., van der Pal, Helena J.H., Kremer, Leontien C.M., Kok, Wouter E.M., and Kapusta, Livia

Published
2023
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7. Self-reported outcomes on oral health and oral health-related quality of life in long-term childhood cancer survivors—A DCCSS-LATER 2 Study

Author

Stolze, Juliette, Raber-Durlacher, Judith E., Loonen, Jacqueline J., Teepen, Jop C., Ronckers, Cécile M., Tissing, Wim J. E., de Vries, Andrica C. H., Neggers, Sebastian J. C. M. M., Dulmen-den Broeder, Eline, Heuvel-Eibrink, Marry M., van der Pal, Helena J. H., Versluys, A. Birgitta, Heiden-van der Loo, Margriet, Louwerens, Marloes, Kremer, Leontien C. M., Bresters, Dorine, and Brand, Henk S.

Published
2023
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8. Unhealthy lifestyle behaviors, overweight, and obesity among childhood cancer survivors in the Netherlands: A DCCSS LATER study.

Author

Bouwman, Eline, Penson, Adriaan, de Valk, Maud, van den Oever, Selina R., van der Pal, Helena J. H., van Dulmen‐den Broeder, Eline, Blijlevens, Nicole M. A., Bresters, Dorine, Feijen, Elizabeth A. M., van den Heuvel‐Eibrink, Marry M., van der Heiden‐van der Loo, Margriet, Michel, Gisela, Ronckers, Cécile M., Teepen, Jop C., Tissing, Wim J. E., Versluys, Birgitta A. B., Kremer, Leontien C. M., Pluijm, Saskia M. F., and Loonen, Jacqueline J.

Subjects
HEALTH behavior, CHILDHOOD cancer, CANCER survivors, CHILDHOOD obesity, UNHEALTHY lifestyles, ADOLESCENT smoking
Abstract

Background: The objective of this study was to examine the prevalence of unhealthy lifestyle behaviors, overweight, and obesity in Dutch childhood cancer survivors (CCSs) compared with sibling controls and the Dutch general population. Other aims were to assess associated factors of unhealthy lifestyle behaviors, overweight, and obesity and to identify subgroups of CCSs at risk for these unhealthy statuses. Methods: The authors included 2253 CCSs and 906 siblings from the Dutch Childhood Cancer Survivor Study‐Late Effects After Childhood Cancer cohort, part 1, and added data from the Dutch general population. Questionnaire data were collected on overweight and obesity (body mass index >25.0 kg/m2), meeting physical activity guidelines (>150 minutes per week of moderate or vigorous exercises), excessive alcohol consumption (>14 and >21 alcoholic consumptions per week for women and men, respectively), daily smoking, and monthly drug use. Multivariable logistic regression analyses and two‐step cluster analyses were performed to examine sociodemographic‐related, health‐related, cancer‐related, and treatment‐related associated factors of unhealthy lifestyle behaviors and to identify subgroups of CCSs at risk for multiple unhealthy behaviors. Results: CCSs more often did not meet physical activity guidelines than their siblings (30.0% vs. 19.3%; p <.001). Married as marital status, lower education level, nonstudent status, and comorbidities were common associated factors for a body mass index ≥25.0 kg/m2 and insufficient physical activity, whereas male sex and lower education were shared associated factors for excessive alcohol consumption, daily smoking, and monthly drug use. A subgroup of CCSs was identified as excessive alcohol consumers, daily smokers, and monthly drug users. Conclusions: The current results emphasize the factors associated with unhealthy behaviors and the potential identification of CCSs who exhibit multiple unhealthy lifestyle behaviors. The results of this study indicate a higher prevalence of physical inactivity in childhood cancer survivors compared with sibling controls and the Dutch population, emphasizing the necessity for personalized health behavior interventions in childhood cancer survivors. These findings can be used in clinical practice to create awareness and to identify subgroups of childhood cancer survivors who need special attention regarding health behaviors. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Presence and utility of electrocardiographic abnormalities in long-term childhood cancer survivors

Author

de Baat, Esmée C, primary, Merkx, Remy, additional, Leerink, Jan M, additional, Boerhout, Coen, additional, van der Pal, Heleen J H, additional, van Dalen, Elvira C, additional, Loonen, Jacqueline, additional, Bresters, Dorine, additional, van Dulmen-den Broeder, Eline, additional, van der Heiden-van der Loo, Margriet, additional, van den Heuvel, Marry M, additional, Kok, Judith L, additional, Louwerens, Marloes, additional, Neggers, Sebastian J C M M, additional, Ronckers, Cecline M, additional, Teepen, Jop C, additional, Tissing, Wim J E, additional, de Vries, Andrica C, additional, Kapusta, Livia, additional, Kremer, Leontien C M, additional, Mavinkurve-Groothuis, Annelies M C, additional, Kok, Wouter E M, additional, and Feijen, Elizabeth A M, additional

Published
2024
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10. Surveillance for subsequent neoplasms of the CNS for childhood, adolescent, and young adult cancer survivors: a systematic review and recommendations from the International Late Effects of Childhood Cancer Guideline Harmonization Group

Author

Bowers, Daniel C, Verbruggen, Lisanne C, Kremer, Leontien C M, Hudson, Melissa M, Skinner, Roderick, Constine, Louis S, Sabin, Noah D, Bhangoo, Ranjeev, Haupt, Riccardo, Hawkins, Mike M, Jenkinson, Helen, Khan, Raja B, Klimo, Paul, Jr, Pretorius, Pieter, Ng, Antony, Reulen, Raoul C, Ronckers, Cécile M, Sadighi, Zsila, Scheinemann, Katrin, Schouten-van Meeteren, Netteke, Sugden, Elaine, Teepen, Jop C, Ullrich, Nicole J, Walter, Andrew, Wallace, W Hamish, Oeffinger, Kevin C, Armstrong, Gregory T, van der Pal, Helena J H, and Mulder, Renée L

Published
2021
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11. The cumulative burden of self‐reported, clinically relevant outcomes in long‐term childhood cancer survivors and implications for survivorship care: A DCCSS LATER study.

Author

Streefkerk, Nina, Teepen, Jop C., Feijen, Elizabeth A. M., Jóźwiak, Katarzyna, van der Pal, Helena J. H., Ronckers, Cecile M., De Vries, Andrica C. H., Van der Heiden‐van Der Loo, Margriet, Hollema, Nynke, van den Berg, Marleen, Loonen, Jacqueline, Grootenhuis, Martha A., Bresters, Dorine, Versluys, A. Brigitta, van Dulmen‐den Broeder, Eline, van den Heuvel‐Eibrink, Marry M., van Leeuwen, Flora E., Neggers, Sebastian J. C. M. M., Van Santen, Hanneke M., and Hawkins, Mike

Subjects
*CHILDHOOD cancer, *CANCER survivors, *MISSING data (Statistics), *TUMOR treatment, *CONFIDENCE intervals
Abstract

Background: The aim of this study is to evaluate how cumulative burden of clinically relevant, self‐reported outcomes in childhood cancer survivors (CCSs) compares to a sibling control group and to explore how the burden corresponds to levels of care proposed by existing risk stratifications. Methods: The authors invited 5925 5‐year survivors from the Dutch Childhood Cancer Survivor Study (DCCSS LATER) cohort and their 1066 siblings to complete a questionnaire on health outcomes. Health outcomes were validated by self‐reported medication use or medical record review. Missing data on clinically relevant outcomes in CCSs for whom no questionnaire data were available were imputed with predictive mean matching. We calculated the mean cumulative count (MCC) for clinically relevant outcomes. Furthermore, we calculated 30‐year MCC for groups of CCSs based on primary cancer diagnosis and treatment, ranked 30‐year MCC, and compared the ranking to levels of care according to existing risk stratifications. Results: At median 18.5 years after 5‐year survival, 46% of CCSs had at least one clinically relevant outcome. CCSs experienced 2.8 times more health conditions than siblings (30‐year MCC = 0.79; 95% confidence interval [CI], 0.74–0.85 vs. 30‐year MCC = 0.29; 95% CI, 0.25–0.34). CCSs' burden of clinically relevant outcomes consisted mainly of endocrine and vascular conditions and varied by primary cancer type. The ranking of the 30‐year MCC often did not correspond with levels of care in existing risk stratifications. Conclusions: CCSs experience a high cumulative burden of clinically relevant outcomes that was not completely reflected by current risk stratifications. Choices for survivorship care should extend beyond primary tumor and treatment parameters, and should consider also including CCSs' current morbidity. Survivors of childhood cancer experience a high cumulative burden of clinically relevant outcomes. Choices for survivorship care should extend beyond primary tumor and treatment parameters and should also consider including the current morbidity of childhood cancer survivors. [ABSTRACT FROM AUTHOR]

Published
2024
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12. BRAF V600E is associated with higher incidence of second cancers in adults with Langerhans cell histiocytosis

Author

Acosta-Medina, Aldo A., primary, Kemps, Paul G., additional, Zondag, Timo C. E., additional, Abeykoon, Jithma P., additional, Forma-Borst, Jelske, additional, Steenwijk, Eline C., additional, Feijen, Elizabeth A. M., additional, Teepen, Jop C., additional, Bennani, N. Nora, additional, Schram, Susan M., additional, Shah, Mithun V., additional, Davidge-Pitts, Caroline, additional, Koster, Matthew J., additional, Ryu, Jay H., additional, Vassallo, Robert, additional, Tobin, W. Oliver, additional, Young, Jason R., additional, Dasari, Surendra, additional, Rech, Karen, additional, Ravindran, Aishwarya, additional, Cleven, Arjen H. G., additional, Verdijk, Robert M., additional, van Noesel, Carel J. M., additional, Balgobind, Brian V., additional, Bouma, Gerrit Joan, additional, Saeed, Peerooz, additional, Bramer, Jos A. M., additional, de Groen, Ruben A. L., additional, Vermaat, Joost S. P., additional, van de Sande, Michiel A. J., additional, Smit, Egbert F., additional, Langerak, Anton W., additional, van Wezel, Tom, additional, Tonino, Sanne H., additional, van den Bos, Cor, additional, van Laar, Jan A. M., additional, Go, Ronald S., additional, Goyal, Gaurav, additional, and van Halteren, Astrid G. S., additional

Published
2023
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15. Risk Factors for Primary Bone Cancer After Childhood Cancer: A PanCare Childhood and Adolescent Cancer Survivor Care and Follow-Up Studies Nested Case-Control Study

Author

Reulen, Raoul C., primary, Winter, David L., additional, Diallo, Ibrahim, additional, Veres, Cristina, additional, Llanas, Damien, additional, Allodji, Rodrigue S., additional, Bagnasco, Francesca, additional, Bárdi, Edit, additional, Feijen, Elizabeth A.M., additional, Alessi, Daniela, additional, Fidler-Benaoudia, Miranda M., additional, Høgsholt, Stine, additional, Teepen, Jop C., additional, Linge, Helena, additional, Haddy, Nadia, additional, Byrne, Julianne, additional, Debiche, Ghazi, additional, Grabow, Desiree, additional, Gudmundsdottir, Thorgerdur, additional, Fauchery, Romain, additional, Zrafi, Wael, additional, Michel, Gisela, additional, Øfstaas, Hilde, additional, Kaatsch, Peter, additional, Vu-Bezin, Giao, additional, Jenkinson, Helen, additional, Kaiser, Melanie, additional, Skinner, Roderick, additional, Cole, Trevor, additional, Waespe, Nicolas, additional, Sommer, Grit, additional, Nordenfelt, Susanne, additional, Jankovic, Momcilo, additional, Lähteenmäki Taalas, Tuomas, additional, Maule, Milena M., additional, van der Pal, Helena J.H., additional, Ronckers, Cécile M., additional, van Leeuwen, Flora E., additional, Kok, Judith L., additional, Terenziani, Monica, additional, Winther Gunnes, Maria, additional, Wiebe, Thomas, additional, Sacerdote, Carlotta, additional, Jakab, Zsuzsanna, additional, Haupt, Riccardo, additional, Lähteenmäki, Päivi M., additional, Zadravec Zaletel, Lorna, additional, Kuehni, Claudia E., additional, Falck Winther, Jeanette, additional, Kremer, Leontien C.M., additional, Hjorth, Lars, additional, de Vathaire, Florent, additional, and Hawkins, Michael M., additional

Published
2023
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16. Adverse late health outcomes among children treated with 3D radiotherapy techniques: Study design of the Dutch pediatric 3D‐RT study

Author

Beijer, Josien G. M., primary, Kok, Judith L., additional, Janssens, Geert O., additional, Streefkerk, Nina, additional, de Vries, Andrica C. H., additional, Slagter, Cleo, additional, Maduro, John H., additional, Kroon, Petra S., additional, Grootenhuis, Martha A., additional, van Dulmen‐den Broeder, Eline, additional, Loonen, Jacqueline J., additional, Wendling, Markus, additional, Tissing, Wim J. E., additional, van der Pal, Helena J., additional, Louwerens, Marloes, additional, Bel, Arjan, additional, den Hartogh, Jaap, additional, van der Heiden‐van der Loo, Margriet, additional, Kremer, Leontien C. M., additional, Teepen, Jop C., additional, and Ronckers, Cécile M., additional

Published
2023
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17. Clinical evaluation of late outcomes in Dutch childhood cancer survivors: Methodology of the DCCSS LATER 2 study

Author

Feijen, Elizabeth A. M., primary, Teepen, Jop C., additional, van Dulmen‐den Broeder, Eline, additional, van den Heuvel‐Eibrink, Marry M., additional, van der Heiden‐van der Loo, Margriet, additional, van der Pal, Helena J. H., additional, de Vries, Andrica C. H., additional, Louwerens, Marloes, additional, Bresters, Dorine, additional, Versluys, Birgitta, additional, de Ridder, Hanneke, additional, Veening, Margreet, additional, van Leeuwen, Flora E., additional, Grootenhuis, Martha, additional, Maurice‐Stam, Heleen, additional, van Santen, Hanneke M., additional, Neggers, Sebastian J. C. M. M., additional, Pluijm, Saskia, additional, den Hartogh, Jaap, additional, Ronckers, Cécile M., additional, Tissing, Wim J. E., additional, Loonen, Jacqueline J., additional, and Kremer, Leontien C. M., additional

Published
2023
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18. BRAFV600Eis associated with higher incidence of second cancers in adults with Langerhans cell histiocytosis

Author

Acosta-Medina, Aldo A., Kemps, Paul G., Zondag, Timo C. E., Abeykoon, Jithma P., Forma-Borst, Jelske, Steenwijk, Eline C., Feijen, Elizabeth A. M., Teepen, Jop C., Bennani, N. Nora, Schram, Susan M., Shah, Mithun V., Davidge-Pitts, Caroline, Koster, Matthew J., Ryu, Jay H., Vassallo, Robert, Tobin, W. Oliver, Young, Jason R., Dasari, Surendra, Rech, Karen, Ravindran, Aishwarya, Cleven, Arjen H. G., Verdijk, Robert M., van Noesel, Carel J. M., Balgobind, Brian V., Bouma, Gerrit Joan, Saeed, Peerooz, Bramer, Jos A. M., de Groen, Ruben A. L., Vermaat, Joost S. P., van de Sande, Michiel A. J., Smit, Egbert F., Langerak, Anton W., van Wezel, Tom, Tonino, Sanne H., van den Bos, Cor, van Laar, Jan A. M., Go, Ronald S., Goyal, Gaurav, and van Halteren, Astrid G. S.

Abstract

[Display omitted]

Published
2023
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19. Risk of subsequent primary lymphoma in a cohort of 69,460 five‐year survivors of childhood and adolescent cancer in Europe: The PanCareSurFup study

Author

Dudley, Isabelle M., primary, Sunguc, Ceren, additional, Heymer, Emma J., additional, Winter, David L., additional, Teepen, Jop C., additional, Belle, Fabiën N., additional, Bárdi, Edit, additional, Bagnasco, Francesca, additional, Gudmundsdottir, Thorgerdur, additional, Skinner, Roderick, additional, Michel, Gisela, additional, Byrne, Julianne, additional, Øfstaas, Hilde, additional, Jankovic, Momcilo, additional, Mazić, Maja Česen, additional, Mader, Luzius, additional, Loonen, Jaqueline, additional, Garwicz, Stanislaw, additional, Wiebe, Thomas, additional, Alessi, Daniela, additional, Allodji, Rodrigue S., additional, Haddy, Nadia, additional, Grabow, Desiree, additional, Kaatsch, Peter, additional, Kaiser, Melanie, additional, Maule, Milena M., additional, Jakab, Zsuzsanna, additional, Gunnes, Maria Winther, additional, Terenziani, Monica, additional, Zaletel, Lorna Zadravec, additional, Kuehni, Claudia E., additional, Haupt, Riccardo, additional, de Vathaire, Florent, additional, Kremer, Leontien C., additional, Lähteenmäki, Päivi M., additional, Winther, Jeanette F., additional, Hjorth, Lars, additional, Hawkins, Michael M., additional, and Reulen, Raoul C., additional

Published
2022
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20. Cohort profile: Risk and risk factors for female breast cancer after treatment for childhood and adolescent cancer: an internationally pooled cohort

Author

Wang, Yuehan, primary, Kremer, Leontien C M, additional, van Leeuwen, Flora E, additional, Armstrong, Gregory T, additional, Leisenring, Wendy, additional, de Vathaire, Florent, additional, Hudson, Melissa M, additional, Kuehni, Claudia E, additional, Arnold, Michael A, additional, Haddy, Nadia, additional, Demoor-Goldschmidt, Charlotte, additional, Diallo, Ibrahima, additional, Howell, Rebecca M, additional, Ehrhardt, Matthew J, additional, Moskowitz, Chaya S, additional, Neglia, Joseph P, additional, van der Pal, Helena J H, additional, Robison, Leslie L, additional, Schaapveld, Michael, additional, Turcotte, Lucie M, additional, Waespe, Nicolas, additional, Ronckers, Cécile M, additional, and Teepen, Jop C, additional

Published
2022
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21. Risk of subsequent primary oral cancer in a cohort of 69,460 5-year survivors of childhood and adolescent cancer in Europe: the PanCareSurFup study

Author

Sunguc, Ceren, primary, Hawkins, Michael M., additional, Winter, David L., additional, Dudley, Isabelle M., additional, Heymer, Emma J., additional, Teepen, Jop C., additional, Allodji, Rodrigue S., additional, Belle, Fabiën N., additional, Bagnasco, Francesca, additional, Byrne, Julianne, additional, Bárdi, Edit, additional, Ronckers, Cécile M., additional, Haddy, Nadia, additional, Gudmundsdottir, Thorgerdur, additional, Garwicz, Stanislaw, additional, Jankovic, Momcilo, additional, van der Pal, Helena J. H., additional, Mazić, Maja Česen, additional, Schindera, Christina, additional, Grabow, Desiree, additional, Maule, Milena M., additional, Kaatsch, Peter, additional, Kaiser, Melanie, additional, Fresneau, Brice, additional, Michel, Gisela, additional, Skinner, Roderick, additional, Wiebe, Thomas, additional, Sacerdote, Carlotta, additional, Jakab, Zsuzsanna, additional, Gunnes, Maria Winther, additional, Terenziani, Monica, additional, Winther, Jeanette F., additional, Lähteenmäki, Päivi M., additional, Zaletel, Lorna Zadravec, additional, Kuehni, Claudia E., additional, Kremer, Leontien C., additional, Haupt, Riccardo, additional, de Vathaire, Florent, additional, Hjorth, Lars, additional, and Reulen, Raoul C., additional

Published
2022
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22. BRAFV600E is associated with higher incidence of second cancers in adults with Langerhans cell histiocytosis

Author

Acosta-Medina, Aldo A., Kemps, Paul G., Zondag, Timo C. E., Abeykoon, Jithma P., Borst, Jelske, Steenwijk, Eline C., Feijen, Elizabeth A. M., Teepen, Jop C., Bennani, N. Nora, Schram, Susan M., Shah, Mithun V., Davidge-Pitts, Caroline, Koster, Matthew J., Ryu, Jay H., Vassallo, Robert, Tobin, W. Oliver, Young, Jason R., Dasari, Surendra, Rech, Karen, Ravindran, Aishwarya, Cleven, Arjen H. G., Verdijk, Robert M., van Noesel, Carel J. M., Balgobind, Brian V., Bouma, Gerrit Joan, Saeed, Peerooz, Bramer, Jos A. M., de Groen, Ruben A. L., Vermaat, Joost S. P., van de Sande, Michiel A. J., Smit, Egbert F., Langerak, Anton W., van Wezel, Tom, Tonino, Sanne H., van den Bos, Cor, van Laar, Jan A. M., Go, Ronald S., Goyal, Gaurav, and van Halteren, Astrid G. S.

Published
2023
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23. Prevalence and Risk Factors for Hyposalivation and Xerostomia in Childhood Cancer Survivors Following Different Treatment Modalities—A Dutch Childhood Cancer Survivor Study Late Effects 2 Clinical Study (DCCSS LATER 2)

Author

Stolze, Juliette, primary, Teepen, Jop C., additional, Raber-Durlacher, Judith E., additional, Loonen, Jacqueline J., additional, Kok, Judith L., additional, Tissing, Wim J. E., additional, de Vries, Andrica C. H., additional, Neggers, Sebastian J. C. M. M., additional, van Dulmen-den Broeder, Eline, additional, van den Heuvel-Eibrink, Marry M., additional, van der Pal, Helena J. H., additional, Versluys, A. Birgitta, additional, van der Heiden-van der Loo, Margriet, additional, Louwerens, Marloes, additional, Kremer, Leontien C. M., additional, Brand, Henk S., additional, and Bresters, Dorine, additional

Published
2022
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25. Male breast cancer after childhood cancer: Systematic review and analyses in the PanCareSurFup cohort

Author

Wang, Yuehan, primary, Reulen, Raoul C., additional, Kremer, Leontien C.M., additional, de Vathaire, Florent, additional, Haupt, Riccardo, additional, Zadravec Zaletel, Lorna, additional, Bagnasco, Francesca, additional, Demoor-Goldschmidt, Charlotte, additional, van Dorp, Willem J., additional, Haddy, Nadia, additional, Hjorth, Lars, additional, Jakab, Zsuzsanna, additional, Kuehni, Claudia E., additional, Lähteenmäki, Päivi M., additional, van der Pal, Helena J.H., additional, Sacerdote, Carlotta, additional, Skinner, Roderick, additional, Terenziani, Monica, additional, Wesenberg, Finn, additional, Winther, Jeanette F., additional, van Leeuwen, Flora E., additional, Hawkins, Mike M., additional, Teepen, Jop C., additional, van Dalen, Elvira C., additional, and Ronckers, Cécile M., additional

Published
2022
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26. Questionnaire‐ and linkage‐based outcomes in Dutch childhood cancer survivors: Methodology of the DCCSS LATER study part 1.

Author

Teepen, Jop C., Kok, Judith L., Feijen, Elizabeth A. M., Loonen, Jacqueline J., van den Heuvel‐Eibrink, Marry M., van der Pal, Helena J., Tissing, Wim J. E., Bresters, Dorine, Versluys, Birgitta, Grootenhuis, Martha A., Louwerens, Marloes, Neggers, Sebastian J. C. M. M., van Santen, Hanneke M., de Vries, Andrica, Janssens, Geert O., den Hartogh, Jaap G., van Leeuwen, Flora E., Hollema, Nynke, Streefkerk, Nina, and Kilsdonk, Ellen

Subjects
*CHILDHOOD cancer, *CANCER survivors, *MEDICAL registries, *MEDICAL care use, *PEDIATRIC oncology, *CANCER fatigue
Abstract

Background: Childhood cancer survivors are at risk for developing long‐term adverse health outcomes. To identify the risk of and risk factors for specific health outcomes, well‐established cohorts are needed with detailed information on childhood cancer diagnosis, treatment, and health outcomes. We describe the design, methodology, characteristics, and data availability of the Dutch Childhood Cancer Survivor Study LATER cohort (1963–2001) part 1; questionnaire and linkage studies. Methods: The LATER cohort includes 5‐year childhood cancer survivors, diagnosed in the period 1963–2001, and before the age of 18 in any of the seven former pediatric oncology centers in the Netherlands. Information on health outcomes from survivors and invited siblings of survivors was collected by questionnaires and linkages to medical registries. Results: In total, 6165 survivors were included in the LATER cohort. Extensive data on diagnosis and treatment have been collected. Information on a variety of health outcomes has been ascertained by the LATER questionnaire study and linkages with several registries for subsequent tumors, health care use, and hospitalizations. Conclusion: Research with data of the LATER cohort will provide new insights into risks of and risk factors for long‐term health outcomes. This can enhance risk stratification for childhood cancer survivors and inform surveillance guidelines and development of interventions to prevent (the impact of) long‐term adverse health outcomes. The data collected will be a solid baseline foundation for future follow‐up studies. [ABSTRACT FROM AUTHOR]

Published
2023
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27. Risk of subsequent primary lymphoma in a cohort of 69,460 five‐year survivors of childhood and adolescent cancer in Europe: The PanCareSurFup study.

Author

Dudley, Isabelle M., Sunguc, Ceren, Heymer, Emma J., Winter, David L., Teepen, Jop C., Belle, Fabiën N., Bárdi, Edit, Bagnasco, Francesca, Gudmundsdottir, Thorgerdur, Skinner, Roderick, Michel, Gisela, Byrne, Julianne, Øfstaas, Hilde, Jankovic, Momcilo, Mazić, Maja Česen, Mader, Luzius, Loonen, Jaqueline, Garwicz, Stanislaw, Wiebe, Thomas, and Alessi, Daniela

Subjects
CHILDHOOD cancer, MEDICAL personnel, NEPHROBLASTOMA, OSTEOSARCOMA, HODGKIN'S disease
Abstract

Background: Survivors of Hodgkin lymphoma (HL) are at risk of developing non‐Hodgkin lymphoma (NHL) after treatment; however, the risks of developing subsequent primary lymphomas (SPLs), including HL and NHL, after different types of childhood cancer are unknown. The authors quantified the risk of SPLs using the largest cohort of childhood cancer survivors worldwide. Methods: The Pan‐European Network for Care of Survivors After Childhood and Adolescent Cancer (PanCare) Survivor Care and Follow‐Up Studies (PanCareSurFup) cohort includes 69,460 five‐year survivors of childhood cancer, diagnosed during 1940 through 2008, from 12 European countries. Risks of SPLs were quantified by standardized incidence ratios (SIRs) and relative risks (RRs) using multivariable Poisson regression. Results: Overall, 140 SPLs, including 104 NHLs and 36 HLs, were identified. Survivors were at 60% increased risk of an SPL compared with the general population (SIR, 1.6; 95% confidence interval [CI], 1.4–1.9). Survivors were twice as likely to develop NHL (SIR, 2.3; 95% CI, 1.9–2.8), with the greatest risks among survivors of HL (SIR, 7.1; 95% CI, 5.1–10.0), Wilms tumor (SIR, 3.1; 95% CI, 1.7–5.7), leukemia (SIR, 2.8; 95% CI, 1.8–4.4), and bone sarcoma (SIR, 2.7; 95% CI, 1.4–5.4). Treatment with chemotherapy for any cancer doubled the RR of NHL (RR, 2.1; 95% CI, 1.2–3.9), but treatment with radiotherapy did not (RR, 1.2; 95% CI, 0.7–2.0). Survivors were at similar risk of developing a subsequent HL as the general population (SIR, 1.1; 95% CI, 0.8–1.5). Conclusions: In addition to HL, the authors show here for the first time that survivors of Wilms tumor, leukemia, and bone sarcoma are at risk of NHL. Survivors and health care professionals should be aware of the risk of NHL in these survivors and in any survivors treated with chemotherapy. Using data from 69,460 five‐year survivors of childhood cancer across Europe, the authors investigated the risks of subsequent primary lymphoma within the largest cohort reported to date. Novel findings include the identification of an increased risk of non‐Hodgkin lymphoma among survivors of Wilms tumor, leukemia, and bone sarcoma and in any survivors treated with chemotherapy. [ABSTRACT FROM AUTHOR]

Published
2023
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30. Long-Term Effects of Childhood Cancer Treatment on Dentition and Oral Health: A Dentist Survey Study from the DCCSS LATER 2 Study

Author

Stolze, Juliette, primary, Vlaanderen, Kim C. E., additional, Holtbach, Frederique C. E. D., additional, Teepen, Jop C., additional, Kremer, Leontien C. M., additional, Loonen, Jacqueline J., additional, van Dulmen-den Broeder, Eline, additional, Heuvel-Eibrink, Marry M. van den, additional, Pal, Helena J. H. van der, additional, Versluys, Birgitta, additional, van der Heiden-van der Loo, Margriet, additional, Louwerens, Marloes, additional, Raber-Durlacher, Judith E., additional, Bresters, Dorine, additional, and Brand, Henk S., additional

Published
2021
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31. Clinical characteristics of subsequent histologically confirmed meningiomas in long-term childhood cancer survivors: A Dutch LATER study

Author

Verbruggen, Lisanne C., primary, Kok, Judith L., additional, Teepen, Jop C., additional, Janssens, Geert O., additional, de Boer, Charlotte M., additional, Stalpers, Lukas J.A., additional, Vernooij, Meike W., additional, van Dulmen-den Broeder, Eline, additional, Loonen, Jacqueline J., additional, van den Heuvel-Eibrink, Marry M., additional, Tissing, Wim J.E., additional, van der Heiden-van der Loo, Margriet, additional, Versluys, Anne Birgitta, additional, Neggers, Sebastian J.C.M.M., additional, van Leeuwen, Flora E., additional, Hoving, Eelco W., additional, Wesseling, Pieter, additional, Kremer, Leontine C.M., additional, Ronckers, Cécile M., additional, van der Pal, Helena J.H., additional, Louwerens, Marloes, additional, de Vries, Andrica, additional, Jaspers, Monique, additional, Hollema, Nynke, additional, den Hartogh, Jaap, additional, and Schouten-van Meeteren, Netteke, additional

Published
2021
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32. Subsequent Primary Neoplasms

Author

Hawkins, Michael, primary, Bhatia, Smita, additional, Henderson, Tara O., additional, Nathan, Paul C., additional, Yan, Adam, additional, Teepen, Jop C., additional, and Morton, Lindsay M., additional

Published
2020
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33. Risk of digestive cancers in a cohort of 69 460 five-year survivors of childhood cancer in Europe: the PanCareSurFup study

Author

Reulen, Raoul C, primary, Wong, Kwok F, additional, Bright, Chloe J, additional, Winter, David L, additional, Alessi, Daniela, additional, Allodji, Rodrigue M, additional, Bagnasco, Francesca, additional, Bárdi, Edit, additional, Bautz, Andrea, additional, Byrne, Julianne, additional, Feijen, Elizabeth AM, additional, Fidler-Benaoudia, Miranda M, additional, Diallo, Ibrahim, additional, Garwicz, Stanislaw, additional, Grabow, Desiree, additional, Gudmundsdottir, Thorgerdur, additional, Guha, Joyeeta, additional, Haddy, Nadia, additional, Høgsholt, Stine, additional, Jankovic, Moncilo, additional, Kaatsch, Peter, additional, Kaiser, Melanie, additional, Kuonen, Rahel, additional, Linge, Helena, additional, Øfstaas, Hilde, additional, Ronckers, Cecile M, additional, Hau, Eva-Maria, additional, Skinner, Roderick, additional, van Leeuwen, Flora E, additional, Teepen, Jop C, additional, Veres, Cristina, additional, Zrafi, Wael, additional, Debiche, Ghazi, additional, Llanas, Damien, additional, Terenziani, Monica, additional, Vu-Bezin, Giao, additional, Wesenberg, Finn, additional, Wiebe, Thomas, additional, Sacerdote, Carlotta, additional, Jakab, Zsuzsanna, additional, Haupt, Riccardo, additional, Lähteenmäki, Päivi M, additional, Zadravec Zaletel, Lorna, additional, Kuehni, Claudia E, additional, Winther, Jeanette F, additional, de Vathaire, Florent, additional, Kremer, Leontien C, additional, Hjorth, Lars, additional, and Hawkins, Michael M, additional

Published
2020
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34. Prevalence and risk factors of cancer‐related fatigue in childhood cancer survivors: A DCCSS LATER study.

Author

van Deuren, Sylvia, Penson, Adriaan, van Dulmen‐den Broeder, Eline, Grootenhuis, Martha A., van der Heiden‐van der Loo, Margriet, Bronkhorst, Ewald, Blijlevens, Nicole M. A., Streefkerk, Nina, Teepen, Jop C., Tissing, Wim J. E., van der Pal, Helena J. H., van den Heuvel‐Eibrink, Marry M., Versluys, Birgitta A. B., Bresters, Dorine, van Leeuwen, Flora E., Ronckers, Cécile M., Kremer, Leontien C. M., Knoop, Hans, and Loonen, Jacqueline J.

Subjects
CHILDHOOD cancer, CANCER fatigue, CANCER survivors, LOGISTIC regression analysis, CENTRAL nervous system, ODDS ratio
Abstract

Background: Cancer‐related fatigue is a debilitating late effect after treatment for childhood cancer. The prevalence of fatigue in childhood cancer survivors (CCSs) and associated factors for fatigue has varied widely in previous studies. Two important aspects of cancer‐related fatigue, its severity and chronicity, are often not assessed. This study investigated the prevalence of, and risk factors for, severe chronic fatigue (CF) in a national cohort of Dutch CCSs. Methods: In this study, 2810 CCSs (5‐year survivors of all childhood malignancies diagnosed between 1963 and 2001 with a current age of 12‐65 years) and 1040 sibling controls were included. CF was assessed with the Short Fatigue Questionnaire and was defined as a score ≥ 18 and persistence of fatigue for ≥6 months. Cancer‐ and treatment‐related characteristics, current health problems, and demographic and lifestyle variables were assessed as potential risk factors for CF via multivariable logistic regression analyses. Results: In adult CCSs and sibling controls (≥18 years old), the prevalence of CF was 26.1% and 14.1%, respectively (P <.001). In adolescent CCSs and sibling controls (<18 years old), the prevalence of CF was 10.9% and 3.2%, respectively. Female gender (odds ratio [OR], 2.13; 95% confidence interval [CI], 1.73‐2.62), unemployment (OR, 2.18; 95% CI, 1.67‐2.85), having 1 or more health problems (OR for 1‐2, 1.48; 95% CI, 1.18‐1.87; OR for >2, 2.20; 95% CI, 1.50‐3.21), and a central nervous system diagnosis (OR, 1.74; 95% CI, 1.17‐2.60) were significantly associated with CF in adult CCSs. Conclusions: This study shows that CCSs, regardless of their cancer diagnosis, report CF more often than sibling controls. This study provides new evidence for the prevalence of fatigue in CCSs. One in 4 childhood cancer survivors reports chronic fatigue. Current health problems increase the risk of reporting chronic fatigue. [ABSTRACT FROM AUTHOR]

Published
2022
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36. Large variation in assessment and outcome definitions to describe the burden of long‐term morbidity in childhood cancer survivors: A systematic review

Author

Streefkerk, Nina, primary, Fioole, Lisanne C.E., additional, Beijer, Josien G.M., additional, Feijen, Elizabeth (Lieke) A.M., additional, Teepen, Jop C., additional, Winther, Jeanette F., additional, Ronckers, Cecile M., additional, Loonen, Jaqueline J., additional, Dulmen‐den Broeder, Eline, additional, Skinner, Rod, additional, Hudson, Melissa M., additional, Tissing, Wim J.E., additional, Korevaar, Joke C., additional, Mulder, Renée L., additional, and Kremer, Leontine C.M., additional

Published
2020
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38. Risk of benign meningioma after childhood cancer in the DCOG-LATER cohort : Contributions of radiation dose, exposed cranial volume, and age

Author

Kok, Judith L, Teepen, Jop C, van Leeuwen, Flora E, Tissing, Wim J E, Neggers, Sebastian J C M M, van der Pal, Helena J, Loonen, Jacqueline J, Bresters, Dorine, Versluys, Birgitta, van den Heuvel-Eibrink, Marry M, van Dulmen-den Broeder, Eline, van der Heiden-van der Loo, Margriet, Aleman, Berthe M P, Daniels, Laurien A, Haasbeek, Cornelis J A, Hoeben, Bianca, Janssens, Geert O, Maduro, John H, Oldenburger, Foppe, van Rij, Caroline, Tersteeg, Robbert J H A, Hauptmann, Michael, Kremer, Leontien C M, Ronckers, Cécile M, and DCOG-LATER Study Group

Subjects
Cancer Research, Oncology, childhood cancer survivors, Clinical Neurology, cranial radiotherapy, radiation volume, radiation dose, meningioma
Abstract

Background. Pediatric cranial radiotherapy (CrRT) markedly increases risk of meningiomas. We studied meningioma risk factors with emphasis on independent and joint effects of CrRT dose, exposed cranial volume, exposure age, and chemotherapy. Methods. The Dutch Cancer Oncology Group-Long-Term Effects after Childhood Cancer (DCOG-LATER) cohort includes 5-year childhood cancer survivors (CCSs) whose cancers were diagnosed in 1963-2001. Histologically confirmed benign meningiomas were identified from the population-based Dutch Pathology Registry (PALGA; 1990-2015). We calculated cumulative meningioma incidence and used multivariable Cox regression and linear excess relative risk (ERR) modeling. Results. Among 5843 CCSs (median follow-up: 23.3 y, range: 5.0-52.2 y), 97 developed a benign meningioma, including 80 after full- and 14 after partial-volume CrRT. Compared with CrRT doses of 1-19 Gy, no CrRT was associated with a low meningioma risk (hazard ratio [HR] = 0.04, 95% CI: 0.01-0.15), while increased risks were observed for CrRT doses of 20-39 Gy (HR = 1.66, 95% CI: 0.83-3.33) and 40+ Gy (HR = 2.81, 95% CI: 1.30-6.08). CCSs whose cancers were diagnosed before age 5 versus 10-17 years showed significantly increased risks (HR = 2.38, 95% CI: 1.39-4.07). In this dose-adjusted model, volume was not significantly associated with increased risk (HR full vs partial = 1.66, 95% CI: 0.86-3.22). Overall, the ERR/Gy was 0.30 (95% CI: 0.03-unknown). Dose effects did not vary significantly according to exposure age or CrRT volume. Cumulative incidence after any CrRT was 12.4% (95% CI: 9.8%-15.2%) 40 years after primary cancer diagnosis. Among chemotherapy agents (including methotrexate and cisplatin), only carboplatin (HR = 3.55, 95% CI: 1.62-7.78) appeared associated with meningioma risk. However, we saw no carboplatin dose-response and all 9 exposed cases had high-dose CrRT. Conclusion. After CrRT 1 in 8 survivors developed late meningioma by age 40 years, associated with radiation dose and exposure age, relevant for future treatment protocols and awareness among survivors and physicians.

Published
2019

39. Risk of subsequent primary leukaemias among 69,460 five-year survivors of childhood cancer diagnosed from 1940 to 2008 in Europe: A cohort study within PanCareSurFup

Author

Allodji, Rodrigue S., primary, Hawkins, Mike M., additional, Bright, Chloe J., additional, Fidler-Benaoudia, Miranda M., additional, Winter, David L., additional, Alessi, Daniela, additional, Fresneau, Brice, additional, Journy, Neige, additional, Morsellino, Vera, additional, Bárdi, Edit, additional, Bautz, Andrea, additional, Byrne, Julianne, additional, Feijen, Elizabeth (Lieke) AM., additional, Teepen, Jop C., additional, Vu-Bezin, Giao, additional, Rubino, Carole, additional, Garwicz, Stanislaw, additional, Grabow, Desiree, additional, Gudmundsdottir, Thorgerdur, additional, Guha, Joyeeta, additional, Hau, Eva-Maria, additional, Jankovic, Momcilo, additional, Kaatsch, Peter, additional, Kaiser, Melanie, additional, Linge, Helena, additional, Muraca, Monica, additional, Llanas, Damien, additional, Veres, Cristina, additional, Øfstaas, Hilde, additional, Diallo, Ibrahima, additional, Mansouri, Imene, additional, Ronckers, Cecile M., additional, Skinner, Roderick, additional, Terenziani, Monica, additional, Wesenberg, Finn, additional, Wiebe, Thomas, additional, Sacerdote, Carlotta, additional, Jakab, Zsuzsanna, additional, Haupt, Riccardo, additional, Lähteenmäki, Päivi, additional, Zaletel, Lorna Zadravec, additional, Kuehni, Claudia E., additional, Winther, Jeanette F., additional, Michel, Gisela, additional, Kremer, Leontien C.M., additional, Hjorth, Lars, additional, Haddy, Nadia, additional, de Vathaire, Florent, additional, and Reulen, Raoul C., additional

Published
2019
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41. Risk of digestive cancers in a cohort of 69 460 five-year survivors of childhood cancer in Europe: the PanCareSurFup study

Author

Reulen, Raoul C, Wong, Kwok F, Bright, Chloe J, Winter, David L, Alessi, Daniela, Allodji, Rodrigue M, Bagnasco, Francesca, Bárdi, Edit, Bautz, Andrea, Byrne, Julianne, Feijen, Elizabeth AM, Fidler-Benaoudia, Miranda M, Diallo, Ibrahim, Garwicz, Stanislaw, Grabow, Desiree, Gudmundsdottir, Thorgerdur, Guha, Joyeeta, Haddy, Nadia, Høgsholt, Stine, Jankovic, Moncilo, Kaatsch, Peter, Kaiser, Melanie, Kuonen, Rahel, Linge, Helena, Øfstaas, Hilde, Ronckers, Cecile M, Hau, Eva-Maria, Skinner, Roderick, van Leeuwen, Flora E, Teepen, Jop C, Veres, Cristina, Zrafi, Wael, Debiche, Ghazi, Llanas, Damien, Terenziani, Monica, Vu-Bezin, Giao, Wesenberg, Finn, Wiebe, Thomas, Sacerdote, Carlotta, Jakab, Zsuzsanna, Haupt, Riccardo, La¨hteenma¨ki, Pa¨ivi M, Zadravec Zaletel, Lorna, Kuehni, Claudia E, Winther, Jeanette F, de Vathaire, Florent, Kremer, Leontien C, Hjorth, Lars, and Hawkins, Michael M

Abstract

BackgroundSurvivors of childhood cancer are at risk of subsequent primary neoplasms (SPNs), but the risk of developing specific digestive SPNs beyond age 40 years remains uncertain. We investigated risks of specific digestive SPNs within the largest available cohort worldwide.MethodsThe PanCareSurFup cohort includes 69 460 five-year survivors of childhood cancer from 12 countries in Europe. Risks of digestive SPNs were quantified using standardised incidence ratios (SIRs), absolute excess risks and cumulative incidence.Results427 digestive SPNs (214 colorectal, 62 liver, 48 stomach, 44 pancreas, 59 other) were diagnosed in 413 survivors. Wilms tumour (WT) and Hodgkin lymphoma (HL) survivors were at greatest risk (SIR 12.1; 95% CI 9.6 to 15.1; SIR 7.3; 95% CI 5.9 to 9.0, respectively). The cumulative incidence increased the most steeply with increasing age for WT survivors, reaching 7.4% by age 55% and 9.6% by age 60 years (1.0% expected based on general population rates). Regarding colorectal SPNs, WT and HL survivors were at greatest risk; both seven times that expected. By age 55 years, 2.3% of both WT (95% CI 1.4 to 3.9) and HL (95% CI 1.6 to 3.2) survivors had developed a colorectal SPN—comparable to the risk among members of the general population with at least two first-degree relatives affected.ConclusionsColonoscopy surveillance before age 55 is recommended in many European countries for individuals with a family history of colorectal cancer, but not for WT and HL survivors despite a comparable risk profile. Clinically, serious consideration should be given to the implementation of colonoscopy surveillance while further evaluation of its benefits, harms and cost-effectiveness in WT and HL survivors is undertaken.

Published
2021
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43. Long-Term Risk of Skin Cancer Among Childhood Cancer Survivors: A DCOG-LATER Cohort Study.

Author

Teepen, Jop C, Kok, Judith L, Kremer, Leontien C, Tissing, Wim J E, Heuvel-Eibrink, Marry M van den, Loonen, Jacqueline J, Bresters, Dorine, Pal, Helena J van der, Versluys, Birgitta, Broeder, Eline van Dulmen-den, Nijsten, Tamar, Hauptmann, Michael, Hollema, Nynke, Dolsma, Wil V, Leeuwen, Flora E van, Ronckers, Cécile M, Group, DCOG-LATER Study, van den Heuvel-Eibrink, Marry M, van der Pal, Helena J, and van Dulmen-den Broeder, Eline

Subjects
*CHILDHOOD cancer, *SKIN cancer, *BASAL cell carcinoma, *CANCER patients, *CANCER risk factors, *CANCER radiotherapy complications, *ANTINEOPLASTIC agents
Abstract

Background: Skin cancer is common after radiotherapy among childhood cancer survivors (CCSs). We studied risks and risk factors for subsequent skin cancers, with emphasis on radiation dose, exposed skin surface area, and chemotherapeutic agents.Methods: The DCOG-LATER cohort study includes 5-year Dutch CCSs diagnosed 1963-2001. Subsequent skin cancers were identified from record linkages with the Netherlands Cancer Registry and Dutch Pathology Registry. Incidence rates were compared with general population rates. Multivariable Cox regression models were used, applying a novel method of case-control sampling enabling use of tumor location in cohort analyses. All statistical tests were two-sided.Results: Among 5843 CCSs, 259 developed 1061 basal cell carcinomas (BCCs) (standardized incidence ratio [SIR] = 29.8, 95% confidence interval [CI] = 26.3 to 33.6; excess absolute risk per 10 000 person-years (EAR) = 24.6), 20 had melanoma (SIR = 2.3, 95% CI = 1.4 to 3.5; EAR = 1.1), and 10 had squamous cell carcinoma (SIR = 7.5, 95% CI = 3.6 to 13.8; EAR = 0.8). Cumulative incidence of BCC 40 years after childhood cancer was 19.1% (95% CI = 16.6 to 21.8%) after radiotherapy vs 0.6% expected based on general population rates. After a first BCC, 46.7% had more BCCs later. BCC risk was associated with any radiotherapy to the skin compartment of interest (hazard ratio [HR] = 14.32, 95% CI = 10.10 to 20.29) and with estimated percentage in-field skin surface area (26-75%: HR = 1.99, 95% CI = 1.24 to 3.20; 76-100%: HR = 2.16, 95% CI = 1.33 to 3.53, vs 1-25% exposed; Ptrend among exposed = .002), but not with prescribed radiation dose and likelihood of sun-exposed skin-area. Of all chemotherapy groups examined, only vinca alkaloids increased BCC risk (HR = 1.54, 95% CI = 1.04 to 2.27).Conclusion: CCSs have a strongly, 30-fold increased BCC risk. BCC risk appears to increase with increasing skin surface area exposed. This knowledge underscores the need for awareness by survivors and their health care providers. [ABSTRACT FROM AUTHOR]

Published
2019
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44. The involvement of primary care physicians in care for childhood cancer survivors.

Author

Streefkerk, Nina, Heins, Marianne J., Teepen, Jop C., Feijen, Elizabeth A. M., Bresters, Dorine, Dulmen‐den Broeder, Eline, der Heiden‐van der Loo, Margriet, den Heuvel‐Eibrink, Marry M., Leeuwen, Flora E., Loonen, Jacqueline J., der Pal, Helena J. H., Ronckers, Cécile M., Versluys, A. Birgitta, Tissing, Wim J. E., Korevaar, Joke C., Kremer, Leontien C. M., van Dulmen-den Broeder, Eline, van der Heiden-van der Loo, Margriet, van den Heuvel-Eibrink, Marry M, and van Leeuwen, Flora E

Published
2019
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45. Incidence of and Risk Factors for Histologically Confirmed Solid Benign Tumors Among Long-term Survivors of Childhood Cancer.

Author

Kok, Judith L., Teepen, Jop C., van der Pal, Helena J., van Leeuwen, Flora E., Tissing, Wim J. E., Neggers, Sebastian J. C. M. M., Loonen, Jacqueline J., Louwerens, Marloes, Versluys, Birgitta, van den Heuvel-Eibrink, Marry M., van Dulmen-den Broeder, Eline, Jaspers, Monique M. W., van Santen, Hanneke M., van der Heiden-van der Loo, Margriet, Janssens, Geert O., Maduro, John H., Bruggink, Annette H., Jongmans, Marjolijn C., Kremer, Leontien C. M., and Ronckers, Cécile M.

Published
2019
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48. Colorectal Adenomas and Cancers After Childhood Cancer Treatment: A DCOG-LATER Record Linkage Study.

Author

Teepen, Jop C., Kok, Judith L., van Leeuwen, Flora E., Tissing, Wim J. E., Dolsma, Wil V., van der Pal, Helena J., Loonen, Jacqueline J., Bresters, Dorine, Versluys, Birgitta, den Heuvel-Eibrink, Marry M. van, van Dulmen-den Broeder, Eline, den Berg, Marleen H. van, van der Heiden-van der Loo, Margriet, Hauptmann, Michael, Jongmans, Marjolijn C., Overbeek, Lucy I., de Vijver, Marc J. van, Kremer, Leontien C. M., Ronckers, Cécile M., and van den Heuvel-Eibrink, Marry M

Subjects
*COLON cancer treatment, *CHILDHOOD cancer, *TUMORS in children, *CANCER chemotherapy, *COHORT analysis
Abstract

Background: Although colorectal adenomas serve as prime target for colorectal cancer (CRC) surveillance in other high-risk groups, data on adenoma risk after childhood cancer are lacking. We evaluated the risk of histologically confirmed colorectal adenomas among childhood cancer survivors. A secondary aim was to assess CRC risk.Methods: The DCOG-LATER cohort study includes five-year Dutch childhood cancer survivors and a sibling comparison group (n = 883). Colorectal tumors were identified from the population-based Dutch Pathology Registry (PALGA). We calculated cumulative incidences of adenomas/CRCs for survivors and siblings. For adenomas, multivariable Cox regression models were used to evaluate potential risk factors. All statistical tests were two-sided.Results: Among 5843 five-year survivors (median follow-up = 24.9 years), 78 individuals developed an adenoma. Cumulative incidence by age 45 years was 3.6% (95% confidence interval [CI] = 2.2% to 5.6%) after abdominopelvic radiotherapy (AP-RT; 49 cases) vs 2.0% (95% CI = 1.3% to 2.8%) among survivors without AP-RT (28 cases; Pdifference = .07) and vs 1.0% (95% CI = 0.3% to 2.6%) among siblings (6 cases) (Pdifference = .03). Factors associated with adenoma risk were AP-RT (hazard ratio [HR] = 2.12, 95% CI = 1.24 to 3.60), total body irradiation (TBI; HR = 10.55, 95% CI = 5.20 to 21.42), cisplatin (HR = 2.13; 95% CI = 0.74 to 6.07 for <480 mg/m²; HR = 3.85, 95% CI = 1.45 to 10.26 for ≥480 mg/m²; Ptrend = .62), a hepatoblastoma diagnosis (HR = 27.12, 95% CI = 8.80 to 83.58), and family history of early-onset CRC (HR = 20.46, 95% CI = 8.10 to 51.70). Procarbazine was statistically significantly associated among survivors without AP-RT/TBI (HR = 2.71, 95% CI = 1.28 to 5.74). Thirteen CRCs occurred.Conclusion: We provide evidence for excess risk of colorectal adenomas and CRCs among childhood cancer survivors. Adenoma risk factors include AP-RT, TBI, cisplatin, and procarbazine. Hepatoblastoma (familial adenomatous polyposis-associated) and family history of early-onset CRC were confirmed as strong risk factors. A full benefit-vs-harm evaluation of CRC screening among high-risk childhood cancer survivors warrants consideration. [ABSTRACT FROM AUTHOR]

Published
2018
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49. Long-Term Risk of Subsequent Malignant Neoplasms After Treatment of Childhood Cancer in the DCOG LATER Study Cohort: Role of Chemotherapy.

Author

Teepen, Jop C., van Leeuwen, Flora E., Tissing, Wim J., van Dulmen-den Broeder, Eline, van den Heuvel-Eibrink, Marry M., van der Pal, Helena J., Loonen, Jacqueline J., Bresters, Dorine, Versluys, Birgitta, Neggers, Sebastian J. C. M. M., Jaspers, Monique W. M., Hauptmann, Michael, van der Heiden-van der Loo, Margriet, Visser, Otto, Kremer, Leontien C. M., Ronckers, Cécile M., and DCOG LATER Study Group

Published
2017
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50. Risk of subsequent primary leukaemias among 69,460 five-year survivors of childhood cancer diagnosed from 1940 to 2008 in Europe: A cohort study within PanCareSurFup

Author

Allodji, Rodrigue S, Hawkins, Mike M, Bright, Chloe J, Fidler-Benaoudia, Miranda M, Winter, David L, Alessi, Daniela, Fresneau, Brice, Journy, Neige, Morsellino, Vera, Bárdi, Edit, Bautz, Andrea, Byrne, Julianne, Feijen, Elizabeth Lieke Am, Teepen, Jop C, Vu-Bezin, Giao, Rubino, Carole, Garwicz, Stanislaw, Grabow, Desiree, Gudmundsdottir, Thorgerdur, Guha, Joyeeta, Hau, Eva-Maria, Jankovic, Momcilo, Kaatsch, Peter, Kaiser, Melanie, Linge, Helena, Muraca, Monica, Llanas, Damien, Veres, Cristina, Øfstaas, Hilde, Diallo, Ibrahima, Mansouri, Imene, Ronckers, Cecile M, Skinner, Roderick, Terenziani, Monica, Wesenberg, Finn, Wiebe, Thomas, Sacerdote, Carlotta, Jakab, Zsuzsanna, Haupt, Riccardo, Lähteenmäki, Päivi, Zaletel, Lorna Zadravec, Kuehni, Claudia E, Winther, Jeanette F, Michel, Gisela, Kremer, Leontien C M, Hjorth, Lars, Haddy, Nadia, De Vathaire, Florent, and Reulen, Raoul C

Subjects
610 Medicine & health, 360 Social problems & social services, 3. Good health
Abstract

BACKGROUND Survivors of childhood cancers are at risk of developing subsequent primary leukaemias (SPLs), but the long-term risks beyond 20 years of treatment are still unclear. We investigated the risk of SPLs in five-year childhood cancer survivors using a large-scale pan-European (PanCareSurFup) cohort and evaluated variations in the risk by cancer and demographic factors. METHODS This largest-ever assembled cohort comprises 69,460 five-year childhood cancer survivors from 12 European countries. Standardised incidence ratios (SIRs) and absolute excess risks (AERs) were calculated. RESULTS One hundred fifteen survivors developed an SPL including 86 myeloid leukaemias (subsequent primary myeloid leukaemias [SPMLs]), 17 lymphoid leukaemias and 12 other types of leukaemias; of these SPLs, 31 (27%) occurred beyond 20 years from the first childhood cancer diagnosis. Compared with the general population, childhood cancer survivors had a fourfold increased risk (SIR = 3.7, 95% confidence interval [CI]: 3.1 to 4.5) of developing leukaemia, and eight leukaemias per 100,000 person-years (AER = 7.5, 95% CI: 6.0 to 9.2) occurred in excess of that expected. The risks remained significantly elevated beyond 20 years from the first primary malignancy (SIR = 2.4, 95% CI: 1.6 to 3.4). Overall, the risk ratio for SPML (SIR = 5.8, 95% CI: 4.6 to 7.1) was higher than that for other SPLs. CONCLUSIONS We demonstrate that beyond 20 years after childhood cancer diagnosis, survivors experience an increased risk for SPLs compared with that expected from the general population. Our findings highlight the need for awareness by survivors and their healthcare providers for potential risk related to SPL.

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