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335 results on '"Teefey, Sharlene A."'

1. Influenza vaccination stimulates maturation of the human T follicular helper cell response

Author

Schattgen, Stefan A., Turner, Jackson S., Ghonim, Mohamed A., Crawford, Jeremy Chase, Schmitz, Aaron J., Kim, Hyunjin, Zhou, Julian Q., Awad, Walid, Mettelman, Robert C., Kim, Wooseob, McIntire, Katherine M., Haile, Alem, Klebert, Michael K., Suessen, Teresa, Middleton, William D., Teefey, Sharlene A., Presti, Rachel M., Ellebedy, Ali H., and Thomas, Paul G.

Published
2024
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2. CD4+ T cells exhibit distinct transcriptional phenotypes in the lymph nodes and blood following mRNA vaccination in humans

Author

Borcherding, Nicholas, Kim, Wooseob, Quinn, Michael, Han, Fangjie, Zhou, Julian Q., Sturtz, Alexandria J., Schmitz, Aaron J., Lei, Tingting, Schattgen, Stefan A., Klebert, Michael K., Suessen, Teresa, Middleton, William D., Goss, Charles W., Liu, Chang, Crawford, Jeremy Chase, Thomas, Paul G., Teefey, Sharlene A., Presti, Rachel M., O’Halloran, Jane A., Turner, Jackson S., Ellebedy, Ali H., and Mudd, Philip A.

Published
2024
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3. SARS-CoV-2 mRNA vaccination elicits a robust and persistent T follicular helper cell response in humans.

Author

Mudd, Philip, Minervina, Anastasia, Pogorelyy, Mikhail, Turner, Jackson, Kim, Wooseob, Kalaidina, Elizaveta, Petersen, Jan, Schmitz, Aaron, Lei, Tingting, Haile, Alem, Kirk, Allison, Mettelman, Robert, Crawford, Jeremy, Nguyen, Thi, Rowntree, Louise, Rosati, Elisa, Richards, Katherine, Sant, Andrea, Klebert, Michael, Suessen, Teresa, Middleton, William, Wolf, Joshua, Teefey, Sharlene, OHalloran, Jane, Presti, Rachel, Kedzierska, Katherine, Rossjohn, Jamie, Thomas, Paul, and Ellebedy, Ali

Subjects
CD4(+) T cell, COVID-19, SARS-CoV-2, T follicular helper cell, TCR repertoire, human immunology, lymph node, mRNA vaccination, Adult, B-Lymphocytes, BNT162 Vaccine, COVID-19, Clone Cells, Cohort Studies, Cytokines, Female, Germinal Center, HLA-DP beta-Chains, Humans, Immunity, Immunodominant Epitopes, Jurkat Cells, Lymph Nodes, Male, Middle Aged, Peptides, Protein Multimerization, Receptors, Antigen, T-Cell, SARS-CoV-2, T Follicular Helper Cells, Vaccination, Vaccines, Synthetic, mRNA Vaccines
Abstract

SARS-CoV-2 mRNA vaccines induce robust anti-spike (S) antibody and CD4+ T cell responses. It is not yet clear whether vaccine-induced follicular helper CD4+ T (TFH) cell responses contribute to this outstanding immunogenicity. Using fine-needle aspiration of draining axillary lymph nodes from individuals who received the BNT162b2 mRNA vaccine, we evaluated the T cell receptor sequences and phenotype of lymph node TFH. Mining of the responding TFH T cell receptor repertoire revealed a strikingly immunodominant HLA-DPB1∗04-restricted response to S167-180 in individuals with this allele, which is among the most common HLA alleles in humans. Paired blood and lymph node specimens show that while circulating S-specific TFH cells peak one week after the second immunization, S-specific TFH persist at nearly constant frequencies for at least six months. Collectively, our results underscore the key role that robust TFH cell responses play in establishing long-term immunity by this efficacious human vaccine.

Published
2022

6. SARS-CoV-2 Omicron boosting induces de novo B cell response in humans

Author

Alsoussi, Wafaa B., Malladi, Sameer Kumar, Zhou, Julian Q., Liu, Zhuoming, Ying, Baoling, Kim, Wooseob, Schmitz, Aaron J., Lei, Tingting, Horvath, Stephen C., Sturtz, Alexandria J., McIntire, Katherine M., Evavold, Birk, Han, Fangjie, Scheaffer, Suzanne M., Fox, Isabella F., Mirza, Senaa F., Parra-Rodriguez, Luis, Nachbagauer, Raffael, Nestorova, Biliana, Chalkias, Spyros, Farnsworth, Christopher W., Klebert, Michael K., Pusic, Iskra, Strnad, Benjamin S., Middleton, William D., Teefey, Sharlene A., Whelan, Sean P. J., Diamond, Michael S., Paris, Robert, O’Halloran, Jane A., Presti, Rachel M., Turner, Jackson S., and Ellebedy, Ali H.

Published
2023
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8. Germinal centre-driven maturation of B cell response to mRNA vaccination

Author

Kim, Wooseob, Zhou, Julian Q., Horvath, Stephen C., Schmitz, Aaron J., Sturtz, Alexandria J., Lei, Tingting, Liu, Zhuoming, Kalaidina, Elizaveta, Thapa, Mahima, Alsoussi, Wafaa B., Haile, Alem, Klebert, Michael K., Suessen, Teresa, Parra-Rodriguez, Luis, Mudd, Philip A., Whelan, Sean P. J., Middleton, William D., Teefey, Sharlene A., Pusic, Iskra, O’Halloran, Jane A., Presti, Rachel M., Turner, Jackson S., and Ellebedy, Ali H.

Published
2022
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9. SARS-CoV-2 mRNA vaccines induce persistent human germinal centre responses

Author

Turner, Jackson S., O’Halloran, Jane A., Kalaidina, Elizaveta, Kim, Wooseob, Schmitz, Aaron J., Zhou, Julian Q., Lei, Tingting, Thapa, Mahima, Chen, Rita E., Case, James Brett, Amanat, Fatima, Rauseo, Adriana M., Haile, Alem, Xie, Xuping, Klebert, Michael K., Suessen, Teresa, Middleton, William D., Shi, Pei-Yong, Krammer, Florian, Teefey, Sharlene A., Diamond, Michael S., Presti, Rachel M., and Ellebedy, Ali H.

Published
2021
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11. Human germinal centres engage memory and naive B cells after influenza vaccination

Author

Turner, Jackson S., Zhou, Julian Q., Han, Julianna, Schmitz, Aaron J., Rizk, Amena A., Alsoussi, Wafaa B., Lei, Tingting, Amor, Mostafa, McIntire, Katherine M., Meade, Philip, Strohmeier, Shirin, Brent, Rafael I., Richey, Sara T., Haile, Alem, Yang, Yuhe R., Klebert, Michael K., Suessen, Teresa, Teefey, Sharlene, Presti, Rachel M., Krammer, Florian, Kleinstein, Steven H., Ward, Andrew B., and Ellebedy, Ali H.

Published
2020
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13. Antigen-specific CD4+ T cells exhibit distinct transcriptional phenotypes in the lymph node and blood following vaccination in humans

Author

Mudd, Philip, primary, Borcherding, Nicholas, additional, Kim, Wooseob, additional, Quinn, Michael, additional, Han, Fangjie, additional, Zhou, Julian, additional, Sturtz, Alexandria, additional, Schmitz, Aaron, additional, Lei, Tingting, additional, Schattgen, Stefan, additional, Klebert, Michael, additional, Suessen, Teresa, additional, Middleton, William, additional, Goss, Charles, additional, Liu, Chang, additional, Crawford, Jeremy, additional, Thomas, Paul, additional, Teefey, Sharlene, additional, Presti, Rachel, additional, O'Halloran, Jane, additional, Turner, Jackson, additional, and Ellebedy, Ali, additional

Published
2023
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14. Imaging Algorithms for Evaluating Suspected Rotator Cuff Disease: Society of Radiologists in Ultrasound Consensus Conference Statement

Author

Nazarian, Levon N, Jacobson, Jon A, Benson, Carol B, Bancroft, Laura W, Bedi, Asheesh, McShane, John M, Miller, Theodore T, Parker, Laurence, Smith, Jay, Steinbach, Lynne S, Teefey, Sharlene A, Thiele, Ralf G, Tuite, Michael J, Wise, James N, and Yamaguchi, Ken

Subjects
Pain Research, Bioengineering, Clinical Research, Physical Injury - Accidents and Adverse Effects, Biomedical Imaging, Generic health relevance, Musculoskeletal, Algorithms, Diagnostic Imaging, Humans, Rotator Cuff, Shoulder Pain, Medical and Health Sciences, Nuclear Medicine & Medical Imaging
Abstract

The Society of Radiologists in Ultrasound convened a panel of specialists from a variety of medical disciplines to reach a consensus about the recommended imaging evaluation of painful shoulders with clinically suspected rotator cuff disease. The panel met in Chicago, Ill, on October 18 and 19, 2011, and created this consensus statement regarding the roles of radiography, ultrasonography (US), computed tomography (CT), CT arthrography, magnetic resonance (MR) imaging, and MR arthrography. The consensus panel consisted of two co-moderators, a facilitator, a statistician and health care economist, and 10 physicians who have specialty expertise in shoulder pain evaluation and/or treatment. Of the 13 physicians on the panel, nine were radiologists who were chosen to represent a broad range of skill sets in diagnostic imaging, different practice types (private and academic), and different geographical regions of the United States. Five of the radiologists routinely performed musculoskeletal US as part of their practice and four did not. There was also one representative from each of the following clinical specialties: rheumatology, physical medicine and rehabilitation, orthopedic surgery, and nonoperative sports medicine. The goal of this conference was to construct several algorithms with which to guide the imaging evaluation of suspected rotator cuff disease in patients with a native rotator cuff, patients with a repaired rotator cuff, and patients who have undergone shoulder replacement. The panel hopes that these recommendations will lead to greater uniformity in rotator cuff imaging and more cost-effective care for patients suspected of having rotator cuff abnormality.

Published
2013

15. Spatiotemporal development of the human T follicular helper cell response to Influenza vaccination

Author

Schattgen, Stefan, primary, Turner, Jackson S, additional, Ghonim, Mohamed A, additional, Crawford, Jeremy Chase, additional, Schmitz, Aaron J, additional, Kim, Hyunjin, additional, Zhou, Julian Q, additional, Awad, Walid, additional, Kim, Wooseob, additional, McIntire, Katherine M, additional, Haile, Alem, additional, Klebert, Michael K, additional, Suessen, Teresa, additional, Middleton, William D, additional, Teefey, Sharlene A, additional, Presti, Rachel M, additional, Ellebedy, Ali, additional, and Thomas, Paul, additional

Published
2023
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17. CD4+T cells exhibit distinct transcriptional phenotypes in the lymph nodes and blood following mRNA vaccination in humans

Author

Borcherding, Nicholas, Kim, Wooseob, Quinn, Michael, Han, Fangjie, Zhou, Julian Q., Sturtz, Alexandria J., Schmitz, Aaron J., Lei, Tingting, Schattgen, Stefan A., Klebert, Michael K., Suessen, Teresa, Middleton, William D., Goss, Charles W., Liu, Chang, Crawford, Jeremy Chase, Thomas, Paul G., Teefey, Sharlene A., Presti, Rachel M., O’Halloran, Jane A., Turner, Jackson S., Ellebedy, Ali H., and Mudd, Philip A.

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and mRNA vaccination induce robust CD4+T cell responses. Using single-cell transcriptomics, here, we evaluated CD4+T cells specific for the SARS-CoV-2 spike protein in the blood and draining lymph nodes (dLNs) of individuals 3 months and 6 months after vaccination with the BNT162b2 mRNA vaccine. We analyzed 1,277 spike-specific CD4+T cells, including 238 defined using Trex, a deep learning-based reverse epitope mapping method to predict antigen specificity. Human dLN spike-specific CD4+follicular helper T (TFH) cells exhibited heterogeneous phenotypes, including germinal center CD4+TFHcells and CD4+IL-10+TFHcells. Analysis of an independent cohort of SARS-CoV-2-infected individuals 3 months and 6 months after infection found spike-specific CD4+T cell profiles in blood that were distinct from those detected in blood 3 months and 6 months after BNT162b2 vaccination. Our findings provide an atlas of human spike-specific CD4+T cell transcriptional phenotypes in the dLNs and blood following SARS-CoV-2 vaccination or infection.

Published
2024
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18. Persons with HIV Develop Spike-Specific Lymph Node Germinal Center Responses following SARS-CoV-2 Vaccination

Author

Quinn, Michael, primary, Parra-Rodriguez, Luis, additional, Alsoussi, Wafaa B., additional, Ayres, Chapelle, additional, Klebert, Michael K., additional, Liu, Chang, additional, Suessen, Teresa, additional, Scheaffer, Suzanne M., additional, Middleton, William D., additional, Teefey, Sharlene A., additional, Powderly, William G., additional, Diamond, Michael S., additional, Presti, Rachel M., additional, Ellebedy, Ali H., additional, Turner, Jackson S., additional, O’Halloran, Jane A., additional, and Mudd, Philip A., additional

Published
2023
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19. SARS-CoV-2 Omicron boosting induces de novo B cell response in humans

Author

Alsoussi, Wafaa B., primary, Malladi, Sameer K., additional, Zhou, Julian Q., additional, Liu, Zhuoming, additional, Ying, Baoling, additional, Kim, Wooseob, additional, Schmitz, Aaron J., additional, Lei, Tingting, additional, Horvath, Stephen C., additional, Sturtz, Alexandria J., additional, McIntire, Katherine M., additional, Evavold, Birk, additional, Han, Fangjie, additional, Scheaffer, Suzanne M., additional, Fox, Isabella F., additional, Parra-Rodriguez, Luis, additional, Nachbagauer, Raffael, additional, Nestorova, Biliana, additional, Chalkias, Spyros, additional, Farnsworth, Christopher W., additional, Klebert, Michael K., additional, Pusic, Iskra, additional, Strnad, Benjamin S., additional, Middleton, William D., additional, Teefey, Sharlene A., additional, Whelan, Sean P.J., additional, Diamond, Michael S., additional, Paris, Robert, additional, O’Halloran, Jane A., additional, Presti, Rachel M., additional, Turner, Jackson S., additional, and Ellebedy, Ali H., additional

Published
2022
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22. Germinal centre-driven maturation of B cell response to SARS-CoV-2 vaccination

Author

Kim, Wooseob, primary, Zhou, Julian Q., additional, Sturtz, Alexandria J., additional, Horvath, Stephen C., additional, Schmitz, Aaron J., additional, Lei, Tingting, additional, Kalaidina, Elizaveta, additional, Thapa, Mahima, additional, Alsoussi, Wafaa B., additional, Haile, Alem, additional, Klebert, Michael K., additional, Suessen, Teresa, additional, Parra-Rodriguez, Luis, additional, Mudd, Philip A., additional, Middleton, William D., additional, Teefey, Sharlene A., additional, Pusic, Iskra, additional, O’Halloran, Jane A., additional, Presti, Rachel M., additional, Turner, Jackson S., additional, and Ellebedy, Ali H., additional

Published
2021
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27. Factors affecting healing rates after arthroscopic double-row rotator cuff repair

Author

Tashjian, Robert Z., Hollins, Anthony M., Kim, Hyun-Min, Teefey, Sharlene A., Middleton, William D., Steger-May, Karen, Galatz, Leesa M., and Yamaguchi, Ken

Subjects
Rotator cuff repair -- Patient outcomes, Rotator cuff repair -- Research, Rotator cuff repair -- Methods, Wound healing -- Research, Health, Sports and fitness
Published
2010

28. SARS-CoV-2 mRNA vaccines induce a robust germinal centre reaction in humans

Author

Ellebedy, Ali, primary, Turner, Jackson, additional, O'Halloran, Jane, additional, Kalaidina, Elizaveta, additional, Kim, Wooseob, additional, Schmitz, Aaron, additional, Lei, Tingting, additional, Thapa, Mahima, additional, Chen, Rita, additional, Case, James, additional, Amanat, Fatima, additional, Rauseo, Adriana, additional, Haile, Alem, additional, Klebert, Michael, additional, Suessen, Teresa, additional, Middleton, William, additional, Krammer, Florian, additional, Teefey, Sharlene, additional, Diamond, Michael, additional, Presti, Rachel, additional, Xie, Xuping, additional, and Shi, Pei-Yong, additional

Published
2021
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32. SARS‐CoV‐2 mRNAVaccination Causes Prolonged Increased Cortical Thickening and Vascularity in Ipsilateral Axillary Lymph Nodes

Author

Teefey, Sharlene A., Middleton, William D., Turner, Jackson S., Ellebedy, Ali H., Suessen, Teresa, Wallendorf, Michael, O'Halloran, Jane A., and Presti, Rachel

Abstract

To describe the serial grey‐scale and color Doppler appearance of ipsilateral axillary lymphadenopathy in response to the Pfizer‐BioNTech Severe Acute Respiratory Syndrome Coronavirus (SARS‐CoV‐2) messenger RNA (mRNA) vaccine over 24 to 28 weeks. The data for this study were collected during an observational study to determine whether mRNA vaccination induced a germinal center B cell reaction in blood and draining axillary lymph nodes. The current study evaluated the serial color Doppler and grey‐scale sonographic appearance of these lymph nodes. Ten participants who each underwent 6 sonograms and FNAs over 24 to 28 weeks were included in the study. A total of 11 lateral lymph nodes were identified. Cortical thickness was measured and absence or presence of color Doppler flow in the hilum and lymph node cortex was graded (scale: 0–2). Eleven lateral axillary lymph nodes were biopsied over 24 to 28 weeks. Mean thickness varied through time (P< .001) and was greater weeks 2 to 7 compared to weeks 24 to 28 (mean differences of 2.6 to 1.3; P< .006), but weeks 14 to 17 mean thickness was not different from weeks 24 to 28 (0.57; P= .15). Cortical vascularity was increased in all 11 lymph nodes by week 5. Mean vascularity varied through time (P< .001) and was greater weeks 2 to 14 compared to weeks 24 to 28; mean differences ranged from 1.7 to 0.83 (P< .001). Serial grey‐scale and color Doppler appearance of ipsilateral axillary lymph nodes after mRNA vaccination manifest as increased and prolonged cortical thickening and vascularity that diminishes and approaches normal by 24 to 28 weeks.

Published
2022
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42. Muscle architecture predicts maximum strength and is related to activity levels in cerebral palsy

Author

Moreau, Noelle G., Simpson, Kit N., Teefey, Sharlene A., and Damiano, Diane L.

Subjects
Cerebral palsy -- Physiological aspects -- Care and treatment -- Patient outcomes, Therapeutics, Physiological -- Methods -- Patient outcomes, Physical therapy -- Methods -- Patient outcomes, Health
Abstract

Background. Muscle architecture is known to be predictive of muscle function. However, it is unknown whether this relationship is similar in children and adolescents with and without cerebral palsy (CP). Objective. The objective of this study was to determine whether the architecture of the rectus femoris (RF) and vastus lateralis (VL) muscles was predictive of maximum voluntary knee extensor torque in children and adolescents with and without CP and whether these measures were related to activity and participation levels. Design. A case-control design was used. Methods. Eighteen participants with CP (mean age = 12.0 years, SD = 3.2) at Gross Motor Function Classification System (GMFCS) levels I through IV and 12 age-matched peers with typical development (mean age = 12.3 years, SD = 3.9) were evaluated. Muscle thickness, fascicle length, and fascicle angle of the RF and VL muscles were measured with 2-dimensional, B-mode ultrasound imaging. The activity and participation measures used for participants with CP were the Pediatric Outcomes Data Collection Instrument (PODCD and the Activities Scale for Kids, Performance Version (ASKp). Results. When age and GMFCS level were controlled for, VL muscle thickness was the best predictor of knee extensor isometric torque in the group with CP ([R.sup.2] = .85). This prediction was similar to the prediction from VL muscle thickness and age in participants with typical development ([R.sup.2] = .91). Rectus femoris muscle fascicle length was significantly correlated with the Sports and Physical Functioning Scale of the PODCI (ρ = .49), and VL muscle fascicle angle was correlated with the Transfers and Basic Mobility Scale of the PODCI (r = .47) and with ASKp Locomotion subdomain (r =.50). Limitations. A limitation of this study was the small sample size. Conclusions. Ultrasound measures of VL muscle thickness, adjusted for age and GMFCS level, were highly predictive of maximum torque and have the potential to serve as surrogate measures of voluntary strength (force-generating capacity) in children and adolescents with and without CP., Cerebral palsy (CP) is a group of disorders of movement and posture, often characterized by impairments such as muscle weakness, spasticity (hypertonicity), stiffness, and excessive co-contraction. (1) In children and [...]

Published
2010
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