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2. Efficacy of using autologous cells with graft substitutes for spinal fusion surgery: A systematic review and meta‐analysis of clinical outcomes and imaging features.

Author

Salamanna, F., Contartese, D., Tedesco, G., Ruffilli, A., Manzetti, M., Viroli, G., Traversari, M., Faldini, C., and Giavaresi, G.

Subjects
SPINAL surgery, AUTOTRANSPLANTATION, CELLULAR therapy, SPINE diseases, VISUAL analog scale, SPINAL fusion
Abstract

Over the past several decades, there has been a notable increase in the total number of spinal fusion procedures worldwide. Advanced spinal fusion techniques, surgical approaches, and new alternatives in grafting materials and implants, as well as autologous cellular therapies, have been widely employed for treating spinal diseases. While the potential of cellular therapies to yield better clinical results is appealing, supportive data are needed to confirm this claim. This meta‐analysis aims to compare the radiographic and clinical outcomes between graft substitutes with autologous cell therapies and graft substitutes alone. PubMed, Scopus, Web of Science, ClinicalTrials.gov, and the Cochrane Central Register of Controlled Trials were searched for studies comparing graft substitutes with autologous cell therapies and graft substitutes alone up to February 2024. The risk of bias of the included studies was evaluated using the Downs and Black checklist. The following outcomes were extracted for comparison: fusion success, complications/adverse events, Visual Analog Scale (VAS) score, and Oswestry Disability Index (ODI) score. Thirteen studies involving 836 patients were included, with 7 studies considered for the meta‐analysis. Results indicated that the use of graft substitutes with autologous cell therapies demonstrated higher fusion success rates at 3, 6, and 12 months, lower VAS score at 6 months, and lower ODI score at 3, 6, and 12 months. The complication rate was similar between graft substitutes with autologous cell therapies and graft substitutes alone. Although the current literature remains limited, this meta‐analysis suggests that the incorporation of cellular therapies such as bone marrow and platelet derivatives with graft substitutes is associated with a higher fusion rate and significant improvements in functional status and pain following spinal fusion. Future well‐designed randomized clinical trials are needed to definitively assess the clinical effectiveness of cellular therapies in spinal fusion. [ABSTRACT FROM AUTHOR]

Published
2024
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3. Organization and Activity of Italian Echocardiographic Laboratories: A Survey of the Italian Society of Echocardiography and Cardiovascular Imaging

Author

Ciampi, Q, Pepi, M, Antonini-Canterin, F, Barbieri, A, Barchitta, A, Faganello, G, Miceli, S, Parato, V, Tota, A, Trocino, G, Abbate, M, Accadia, M, Alemanni, R, Angelini, A, Anglano, F, Anselmi, M, Aquila, I, Aramu, S, Avogadri, E, Azzaro, G, Badano, L, Balducci, A, Ballocca, F, Barbarossa, A, Barbati, G, Barletta, V, Barone, D, Becherini, F, Benfari, G, Beraldi, M, Bergandi, G, Bilardo, G, Binno, S, Bolognesi, M, Bongiovi, S, Bragato, R, Braggion, G, Brancaleoni, R, Bursi, F, Dessalvi, C, Cameli, M, Canu, A, Capitelli, M, Capra, A, Carbonara, R, Carbone, M, Carbonella, M, Carrabba, N, Casavecchia, G, Casula, M, Chesi, E, Cicco, S, Citro, R, Cocchia, R, Colombo, B, Colonna, P, Conte, M, Corrado, G, Cortesi, P, Cortigiani, L, Costantino, M, Cozza, F, Cucchini, U, D'Angelo, M, Ros, S, D'Andrea, F, D'Andrea, A, D'Auria, F, De Caridi, G, De Feo, S, De Matteis, G, De Vecchi, S, Del Giudice, C, Dell'Angela, L, Delli Paoli, L, Dentamaro, I, Destefanis, P, Di Fulvio, M, Di Gaetano, R, Di Giannuario, G, Di Gioia, A, Di Martino, L, Di Muro, C, Di Nora, C, Di Salvo, G, Dodi, C, Dogliani, S, Donati, F, Dottori, M, Epifani, G, Fabiani, I, Ferrara, F, Ferrara, L, Ferrua, S, Filice, G, Fiorino, M, Forno, D, Garini, A, Giarratana, G, Gigantino, G, Giorgi, M, Giubertoni, E, Greco, C, Grigolato, M, Marra, W, Holzl, A, Iaiza, A, Iannaccone, A, Ilardi, F, Imbalzano, E, Inciardi, R, Inserra, C, Iori, E, Izzo, A, La Rosa, G, Labanti, G, Lanzone, A, Lanzoni, L, Lapetina, O, Leiballi, E, Librera, M, Lo Conte, C, Lo Monaco, M, Lombardo, A, Luciani, M, Lusardi, P, Magnante, A, Malagoli, A, Malatesta, G, Mancusi, C, Manes, M, Manganelli, F, Mantovani, F, Manuppelli, V, Marchese, V, Marinacci, L, Mattioli, R, Maurizio, C, Mazza, G, Mazza, S, Melis, M, Meloni, G, Merli, E, Milan, A, Minardi, G, Monaco, A, Monte, I, Montresor, G, Moreo, A, Mori, F, Morini, S, Moro, C, Morrone, D, Negri, F, Nipote, C, Nisi, F, Nocco, S, Novello, L, Nunziata, L, Perini, A, Parodi, A, Pasanisi, E, Pastorini, G, Pavasini, R, Pavoni, D, Pedone, C, Pelliccia, F, Pelliciari, G, Pelloni, E, Pergola, V, Perillo, G, Petruccelli, E, Pezzullo, C, Piacentini, G, Picardi, E, Pinna, G, Pizzarelli, M, Pizzuti, A, Poggi, M, Posteraro, A, Privitera, C, Rampazzo, D, Ratti, C, Rettegno, S, Ricci, F, Ricci, C, Rolando, C, Rossi, S, Rovera, C, Ruggieri, R, Russo, M, Sacchi, N, Saladino, A, Sani, F, Sartori, C, Scarabeo, V, Sciacqua, A, Scillone, A, Scopelliti, P, Scorza, A, Scozzafava, A, Serafini, F, Serra, W, Severino, S, Simeone, B, Sirico, D, Solari, M, Spadaro, G, Stefani, L, Strangio, A, Surace, F, Tamborini, G, Tarquinio, N, Tassone, E, Tavarozzi, I, Tchana, B, Tedesco, G, Tinto, M, Torzillo, D, Totaro, A, Triolo, O, Troisi, F, Tusa, M, Vancheri, F, Varasano, V, Venezia, A, Vermi, A, Villari, B, Zampi, G, Zannoni, J, Zito, C, Zugaro, A, Di Bella, G, Carerj, S, Ciampi Q., Pepi M., Antonini-Canterin F., Barbieri A., Barchitta A., Faganello G., Miceli S., Parato V. M., Tota A., Trocino G., Abbate M., Accadia M., Alemanni R., Angelini A., Anglano F., Anselmi M., Aquila I., Aramu S., Avogadri E., Azzaro G., Badano L., Balducci A., Ballocca F., Barbarossa A., Barbati G., Barletta V., Barone D., Becherini F., Benfari G., Beraldi M., Bergandi G., Bilardo G., Binno S. M., Bolognesi M., Bongiovi S., Bragato R. M., Braggion G., Brancaleoni R., Bursi F., Dessalvi C. C., Cameli M., Canu A., Capitelli M., Capra A. C. M., Carbonara R., Carbone M., Carbonella M., Carrabba N., Casavecchia G., Casula M., Chesi E., Cicco S., Citro R., Cocchia R., Colombo B. M., Colonna P., Conte M., Corrado G., Cortesi P., Cortigiani L., Costantino M. F., Cozza F., Cucchini U., D'Angelo M., Ros S. D., D'Andrea F., D'Andrea A., D'Auria F., De Caridi G., De Feo S., De Matteis G. M., De Vecchi S., Del Giudice C., Dell'Angela L., Delli Paoli L., Dentamaro I., Destefanis P., Di Fulvio M., Di Gaetano R., Di Giannuario G., Di Gioia A., Di Martino L. F. M., Di Muro C., Di Nora C., Di Salvo G., Dodi C., Dogliani S., Donati F., Dottori M., Epifani G., Fabiani I., Ferrara F., Ferrara L., Ferrua S., Filice G., Fiorino M., Forno D., Garini A., Giarratana G. A., Gigantino G., Giorgi M., Giubertoni E., Greco C. A., Grigolato M., Marra W. G., Holzl A., Iaiza A., Iannaccone A., Ilardi F., Imbalzano E., Inciardi R., Inserra C. A., Iori E., Izzo A., La Rosa G., Labanti G., Lanzone A. M., Lanzoni L., Lapetina O., Leiballi E., Librera M., Lo Conte C., Lo Monaco M., Lombardo A., Luciani M., Lusardi P., Magnante A., Malagoli A., Malatesta G., Mancusi C., Manes M. T., Manganelli F., Mantovani F., Manuppelli V., Marchese V., Marinacci L., Mattioli R., Maurizio C., Mazza G. A., Mazza S., Melis M., Meloni G., Merli E., Milan A., Minardi G., Monaco A., Monte I., Montresor G., Moreo A., Mori F., Morini S., Moro C., Morrone D., Negri F., Nipote C., Nisi F., Nocco S., Novello L., Nunziata L., Perini A. P., Parodi A., Pasanisi E. M., Pastorini G., Pavasini R., Pavoni D., Pedone C., Pelliccia F., Pelliciari G., Pelloni E., Pergola V., Perillo G., Petruccelli E., Pezzullo C., Piacentini G., Picardi E., Pinna G., Pizzarelli M., Pizzuti A., Poggi M. M., Posteraro A., Privitera C., Rampazzo D., Ratti C., Rettegno S., Ricci F., Ricci C., Rolando C., Rossi S., Rovera C., Ruggieri R., Russo M. G., Sacchi N., Saladino A., Sani F., Sartori C., Scarabeo V., Sciacqua A., Scillone A., Scopelliti P. A., Scorza A., Scozzafava A., Serafini F., Serra W., Severino S., Simeone B., Sirico D., Solari M., Spadaro G. L., Stefani L., Strangio A., Surace F. C., Tamborini G., Tarquinio N., Tassone E. J., Tavarozzi I., Tchana B., Tedesco G., Tinto M., Torzillo D., Totaro A., Triolo O. F., Troisi F., Tusa M., Vancheri F., Varasano V., Venezia A., Vermi A. C., Villari B., Zampi G., Zannoni J., Zito C., Zugaro A., Di Bella G., Carerj S., Ciampi, Q, Pepi, M, Antonini-Canterin, F, Barbieri, A, Barchitta, A, Faganello, G, Miceli, S, Parato, V, Tota, A, Trocino, G, Abbate, M, Accadia, M, Alemanni, R, Angelini, A, Anglano, F, Anselmi, M, Aquila, I, Aramu, S, Avogadri, E, Azzaro, G, Badano, L, Balducci, A, Ballocca, F, Barbarossa, A, Barbati, G, Barletta, V, Barone, D, Becherini, F, Benfari, G, Beraldi, M, Bergandi, G, Bilardo, G, Binno, S, Bolognesi, M, Bongiovi, S, Bragato, R, Braggion, G, Brancaleoni, R, Bursi, F, Dessalvi, C, Cameli, M, Canu, A, Capitelli, M, Capra, A, Carbonara, R, Carbone, M, Carbonella, M, Carrabba, N, Casavecchia, G, Casula, M, Chesi, E, Cicco, S, Citro, R, Cocchia, R, Colombo, B, Colonna, P, Conte, M, Corrado, G, Cortesi, P, Cortigiani, L, Costantino, M, Cozza, F, Cucchini, U, D'Angelo, M, Ros, S, D'Andrea, F, D'Andrea, A, D'Auria, F, De Caridi, G, De Feo, S, De Matteis, G, De Vecchi, S, Del Giudice, C, Dell'Angela, L, Delli Paoli, L, Dentamaro, I, Destefanis, P, Di Fulvio, M, Di Gaetano, R, Di Giannuario, G, Di Gioia, A, Di Martino, L, Di Muro, C, Di Nora, C, Di Salvo, G, Dodi, C, Dogliani, S, Donati, F, Dottori, M, Epifani, G, Fabiani, I, Ferrara, F, Ferrara, L, Ferrua, S, Filice, G, Fiorino, M, Forno, D, Garini, A, Giarratana, G, Gigantino, G, Giorgi, M, Giubertoni, E, Greco, C, Grigolato, M, Marra, W, Holzl, A, Iaiza, A, Iannaccone, A, Ilardi, F, Imbalzano, E, Inciardi, R, Inserra, C, Iori, E, Izzo, A, La Rosa, G, Labanti, G, Lanzone, A, Lanzoni, L, Lapetina, O, Leiballi, E, Librera, M, Lo Conte, C, Lo Monaco, M, Lombardo, A, Luciani, M, Lusardi, P, Magnante, A, Malagoli, A, Malatesta, G, Mancusi, C, Manes, M, Manganelli, F, Mantovani, F, Manuppelli, V, Marchese, V, Marinacci, L, Mattioli, R, Maurizio, C, Mazza, G, Mazza, S, Melis, M, Meloni, G, Merli, E, Milan, A, Minardi, G, Monaco, A, Monte, I, Montresor, G, Moreo, A, Mori, F, Morini, S, Moro, C, Morrone, D, Negri, F, Nipote, C, Nisi, F, Nocco, S, Novello, L, Nunziata, L, Perini, A, Parodi, A, Pasanisi, E, Pastorini, G, Pavasini, R, Pavoni, D, Pedone, C, Pelliccia, F, Pelliciari, G, Pelloni, E, Pergola, V, Perillo, G, Petruccelli, E, Pezzullo, C, Piacentini, G, Picardi, E, Pinna, G, Pizzarelli, M, Pizzuti, A, Poggi, M, Posteraro, A, Privitera, C, Rampazzo, D, Ratti, C, Rettegno, S, Ricci, F, Ricci, C, Rolando, C, Rossi, S, Rovera, C, Ruggieri, R, Russo, M, Sacchi, N, Saladino, A, Sani, F, Sartori, C, Scarabeo, V, Sciacqua, A, Scillone, A, Scopelliti, P, Scorza, A, Scozzafava, A, Serafini, F, Serra, W, Severino, S, Simeone, B, Sirico, D, Solari, M, Spadaro, G, Stefani, L, Strangio, A, Surace, F, Tamborini, G, Tarquinio, N, Tassone, E, Tavarozzi, I, Tchana, B, Tedesco, G, Tinto, M, Torzillo, D, Totaro, A, Triolo, O, Troisi, F, Tusa, M, Vancheri, F, Varasano, V, Venezia, A, Vermi, A, Villari, B, Zampi, G, Zannoni, J, Zito, C, Zugaro, A, Di Bella, G, Carerj, S, Ciampi Q., Pepi M., Antonini-Canterin F., Barbieri A., Barchitta A., Faganello G., Miceli S., Parato V. M., Tota A., Trocino G., Abbate M., Accadia M., Alemanni R., Angelini A., Anglano F., Anselmi M., Aquila I., Aramu S., Avogadri E., Azzaro G., Badano L., Balducci A., Ballocca F., Barbarossa A., Barbati G., Barletta V., Barone D., Becherini F., Benfari G., Beraldi M., Bergandi G., Bilardo G., Binno S. M., Bolognesi M., Bongiovi S., Bragato R. M., Braggion G., Brancaleoni R., Bursi F., Dessalvi C. C., Cameli M., Canu A., Capitelli M., Capra A. C. M., Carbonara R., Carbone M., Carbonella M., Carrabba N., Casavecchia G., Casula M., Chesi E., Cicco S., Citro R., Cocchia R., Colombo B. M., Colonna P., Conte M., Corrado G., Cortesi P., Cortigiani L., Costantino M. F., Cozza F., Cucchini U., D'Angelo M., Ros S. D., D'Andrea F., D'Andrea A., D'Auria F., De Caridi G., De Feo S., De Matteis G. M., De Vecchi S., Del Giudice C., Dell'Angela L., Delli Paoli L., Dentamaro I., Destefanis P., Di Fulvio M., Di Gaetano R., Di Giannuario G., Di Gioia A., Di Martino L. F. M., Di Muro C., Di Nora C., Di Salvo G., Dodi C., Dogliani S., Donati F., Dottori M., Epifani G., Fabiani I., Ferrara F., Ferrara L., Ferrua S., Filice G., Fiorino M., Forno D., Garini A., Giarratana G. A., Gigantino G., Giorgi M., Giubertoni E., Greco C. A., Grigolato M., Marra W. G., Holzl A., Iaiza A., Iannaccone A., Ilardi F., Imbalzano E., Inciardi R., Inserra C. A., Iori E., Izzo A., La Rosa G., Labanti G., Lanzone A. M., Lanzoni L., Lapetina O., Leiballi E., Librera M., Lo Conte C., Lo Monaco M., Lombardo A., Luciani M., Lusardi P., Magnante A., Malagoli A., Malatesta G., Mancusi C., Manes M. T., Manganelli F., Mantovani F., Manuppelli V., Marchese V., Marinacci L., Mattioli R., Maurizio C., Mazza G. A., Mazza S., Melis M., Meloni G., Merli E., Milan A., Minardi G., Monaco A., Monte I., Montresor G., Moreo A., Mori F., Morini S., Moro C., Morrone D., Negri F., Nipote C., Nisi F., Nocco S., Novello L., Nunziata L., Perini A. P., Parodi A., Pasanisi E. M., Pastorini G., Pavasini R., Pavoni D., Pedone C., Pelliccia F., Pelliciari G., Pelloni E., Pergola V., Perillo G., Petruccelli E., Pezzullo C., Piacentini G., Picardi E., Pinna G., Pizzarelli M., Pizzuti A., Poggi M. M., Posteraro A., Privitera C., Rampazzo D., Ratti C., Rettegno S., Ricci F., Ricci C., Rolando C., Rossi S., Rovera C., Ruggieri R., Russo M. G., Sacchi N., Saladino A., Sani F., Sartori C., Scarabeo V., Sciacqua A., Scillone A., Scopelliti P. A., Scorza A., Scozzafava A., Serafini F., Serra W., Severino S., Simeone B., Sirico D., Solari M., Spadaro G. L., Stefani L., Strangio A., Surace F. C., Tamborini G., Tarquinio N., Tassone E. J., Tavarozzi I., Tchana B., Tedesco G., Tinto M., Torzillo D., Totaro A., Triolo O. F., Troisi F., Tusa M., Vancheri F., Varasano V., Venezia A., Vermi A. C., Villari B., Zampi G., Zannoni J., Zito C., Zugaro A., Di Bella G., and Carerj S.

Abstract

Background: The Italian Society of Echocardiography and Cardiovascular Imaging (SIECVI) conducted a national survey to understand better how different echocardiographic modalities are used and accessed in Italy. Methods: We analyzed echocardiography laboratory activities over a month (November 2022). Data were retrieved via an electronic survey based on a structured questionnaire, uploaded on the SIECVI website. Results: Data were obtained from 228 echocardiographic laboratories: 112 centers (49%) in the northern, 43 centers (19%) in the central, and 73 (32%) in the southern regions. During the month of observation, we collected 101,050 transthoracic echocardiography (TTE) examinations performed in all centers. As concern other modalities there were performed 5497 transesophageal echocardiography (TEE) examinations in 161/228 centers (71%); 4057 stress echocardiography (SE) examinations in 179/228 centers (79%); and examinations with ultrasound contrast agents (UCAs) in 151/228 centers (66%). We did not find significant regional variations between the different modalities. The usage of picture archiving and communication system (PACS) was significantly higher in the northern (84%) versus central (49%) and southern (45%) centers (P < 0.001). Lung ultrasound (LUS) was performed in 154 centers (66%), without difference between cardiology and noncardiology centers. The evaluation of left ventricular (LV) ejection fraction was evaluated mainly using the qualitative method in 223 centers (94%), occasionally with the Simpson method in 193 centers (85%), and with selective use of the three-dimensional (3D) method in only 23 centers (10%). 3D TTE was present in 137 centers (70%), and 3D TEE in all centers where TEE was done (71%). The assessment of LV diastolic function was done routinely in 80% of the centers. Right ventricular function was evaluated using tricuspid annular plane systolic excursion in all centers, using tricuspid valve annular systolic velocity by tissue

Published
2023

6. AUTOLOGOUS MESENCHYMAL STEM CELLS IN THE TREATMENT OF SPINAL ANEURYSMAL BONE CYST

Author

Brodano, G.B., primary, Griffoni, C., additional, Facchini, G., additional, Carretta, E., additional, Salamanna, F., additional, Tedesco, G., additional, Evangelisti, G., additional, Terzi, S., additional, Ghermandi, R., additional, Bandiera, S., additional, Girolami, M., additional, Pipola, V., additional, Fini, M., additional, Gasbarrini, A., additional, and Leggi, L., additional

Published
2023
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7. The Scientific Investigation of Unidentified Aerial Phenomena (UAP) Using Multimodal Ground-Based Observatories

Author

Watters, W. A., Loeb, Arthur, Laukien, F., Cloete, R., Delacroix, A., Dobroshinsky, S., Horvath, B., Kelderman, E., Little, S., Masson, E., Mead, A., Randall, M., Schultz, F., Szenher, M., Vervelidou, F., White, A., Ahlstrom, A., Cleland, Carol, Dockal, S., Donahue, N., Elowitz, M., Ezell, C., Gersznowicz, A., Gold, N., Hercz, M. G., Keto, E., Knuth, K. H., Lux, A., Melnick, G. J., Moro-Martín, Amaya, Martín-Torres, F. J., Ribes, D. L., Sail, P., Teodorani, M., Tedesco, J. J., Tedesco, G. T., Tu, M., Zorzano, María Paz, Watters, W. A., Loeb, Arthur, Laukien, F., Cloete, R., Delacroix, A., Dobroshinsky, S., Horvath, B., Kelderman, E., Little, S., Masson, E., Mead, A., Randall, M., Schultz, F., Szenher, M., Vervelidou, F., White, A., Ahlstrom, A., Cleland, Carol, Dockal, S., Donahue, N., Elowitz, M., Ezell, C., Gersznowicz, A., Gold, N., Hercz, M. G., Keto, E., Knuth, K. H., Lux, A., Melnick, G. J., Moro-Martín, Amaya, Martín-Torres, F. J., Ribes, D. L., Sail, P., Teodorani, M., Tedesco, J. J., Tedesco, G. T., Tu, M., and Zorzano, María Paz

Abstract

Unidentified Aerial Phenomena (UAP) have resisted explanation and have received little formal scientific attention for 75 years. A primary objective of the Galileo Project is to build an integrated software and instrumentation system designed to conduct a multimodal census of aerial phenomena and to recognize anomalies. Here we present key motivations for the study of UAP and address historical objections to this research. We describe an approach for highlighting outlier events in the high-dimensional parameter space of our census measurements. We provide a detailed roadmap for deciding measurement requirements, as well as a science traceability matrix (STM) for connecting sought-after physical parameters to observables and instrument requirements. We also discuss potential strategies for deciding where to locate instruments for development, testing, and final deployment. Our instrument package is multimodal and multispectral, consisting of (1) wide-field cameras in multiple bands for targeting and tracking of aerial objects and deriving their positions and kinematics using triangulation; (2) narrow-field instruments including cameras for characterizing morphology, spectra, polarimetry, and photometry; (3) passive multistatic arrays of antennas and receivers for radar-derived range and kinematics; (4) radio spectrum analyzers to measure radio and microwave emissions; (5) microphones for sampling acoustic emissions in the infrasonic through ultrasonic frequency bands; and (6) environmental sensors for characterizing ambient conditions (temperature, pressure, humidity, and wind velocity), as well as quasistatic electric and magnetic fields, and energetic particles. The use of multispectral instruments and multiple sensor modalities will help to ensure that artifacts are recognized and that true detections are corroborated and verifiable. Data processing pipelines are being developed that apply state-of-the-art techniques for multi-sensor data fusion, hypothesis tracki

Published
2023

8. Identification of causes and patterns of albumin structural damages in commercial formulations.

Author

Baldassarre, M., Naldi, M., Zaccherini, G., Pompili, E., Tedesco, D., Nugnes, M., Fabini, E., Pock, K., Tedesco, G., Hegener, O., Bartolini, M., and Caraceni, P.

Abstract

The administration of human albumin (HA) is widely used in patients with decompensated cirrhosis to treat or prevent complications of the disease. HA is given to these patients because of its ability to effectively counteract hypovolemia by acting as a plasma expander. However, several lines of evidence suggest that the non-oncotic properties of the molecule may mediate the beneficial effects. Nevertheless, the HA molecules contained in standard commercial HA solution exhibit a number of oxidative and non-oxidative modifications that may dampen the therapeutic potential of commercial HA formulations. Unfortunately, definitive data on the cause and pattern of HA structural damage in commercial solutions are still lacking, so this study identifies critical steps in the manufacturing process as well as in the shelf life for the onset of structural damage in current commercial solutions. Albumin molecular structure was investigated by using high-performance liquid chromatography/electrospray ionization/mass spectrometry throughout the manufacturing process and at different lengths of shelf-life in standard commercial vials. The LC-MS analysis of samples collected at different steps of the fractionation process indicate that this procedure does not significantly affect albumin quality as the relative amount of reversibly and irreversibly oxidized albumin forms as well as the amount of albumin in its native form at the beginning of the post-production storage period resembles that of healthy donors. Contrary to the manufacturing process, shelf-life at room temperature was found to significantly impair the structural integrity of albumin already after 1 year, with a significant increase of the oxidized (HNA1: +10%; HNA2: 20%) and truncated (N-terminal: +29%) isoforms and a concomitant decrease of the reduced (HMA: -30%) and native (-40%) isoforms. Such results were confirmed by a prospective study in which several strategies to prevent the loss of native albumin in commercial formulation were also tested. This study unveiled that structural damages to the albumin molecule found in commercial formulation do not result from the manufacturing process, but they accumulate during shelf-life at room temperature. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Diophantine Benchmarks for the B-Cell Algorithm

Author

Bull, P., Knowles, A., Tedesco, G., Hone, A., Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Dough, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Bersini, Hugues, editor, and Carneiro, Jorge, editor

Published
2006
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12. Association between changes in body composition and neoadjuvant treatment for pancreatic cancer

Author

Sandini, M, Patino, M, Ferrone, C, Alvarez-Perez, C, Honselmann, K, Paiella, S, Catania, M, Riva, L, Tedesco, G, Casolino, R, Auriemma, A, Salandini, M, Carrara, G, Cristel, G, Damascelli, A, Ippolito, D, D'Onofrio, M, Lillemoe, K, Bassi, C, Braga, M, Gianotti, L, Sahani, D, Fernandez-Del Castillo, C, Sandini M., Patino M., Ferrone C. R., Alvarez-Perez C. A., Honselmann K. C., Paiella S., Catania M., Riva L., Tedesco G., Casolino R., Auriemma A., Salandini M. C., Carrara G., Cristel G., Damascelli A., Ippolito D., D'Onofrio M., Lillemoe K. D., Bassi C., Braga M., Gianotti L., Sahani D., Fernandez-Del Castillo C., Sandini, M, Patino, M, Ferrone, C, Alvarez-Perez, C, Honselmann, K, Paiella, S, Catania, M, Riva, L, Tedesco, G, Casolino, R, Auriemma, A, Salandini, M, Carrara, G, Cristel, G, Damascelli, A, Ippolito, D, D'Onofrio, M, Lillemoe, K, Bassi, C, Braga, M, Gianotti, L, Sahani, D, Fernandez-Del Castillo, C, Sandini M., Patino M., Ferrone C. R., Alvarez-Perez C. A., Honselmann K. C., Paiella S., Catania M., Riva L., Tedesco G., Casolino R., Auriemma A., Salandini M. C., Carrara G., Cristel G., Damascelli A., Ippolito D., D'Onofrio M., Lillemoe K. D., Bassi C., Braga M., Gianotti L., Sahani D., and Fernandez-Del Castillo C.

Abstract

IMPORTANCE Sarcopenia and sarcopenic obesity have been associated with poor outcomes in unresectable pancreatic cancer (PC). Neoadjuvant treatment (NT) is used increasingly to improve resectability; however, its effects on fat and muscle body composition have not been characterized. OBJECTIVES To evaluate whether NT affects muscle mass and adipose tissue in patients with borderline resectable PC (BRPC) and locally advanced PC (LAPC) and determine whether there were potential differences between patients who ultimately underwent resection and those who did not. DESIGN, SETTING, AND PARTICIPANTS In this retrospective cohort study conducted at 4 academic medical centers, 193 patients with BRPC and LAPC undergoing surgical exploration after NT who had available computed tomographic scans (both at diagnosis and preoperatively) and confirmed pancreatic ductal adenocarcinoma were evaluated. The study was conducted from January 2013 to December 2015. Data analysis was performed from September 2016 to May 2017. Measurement of body compartments was evaluated with volume assessment software before and after NT. A radiologist blinded to the patient outcome assessed the areas of skeletal muscle, total adipose tissue, and visceral adipose tissue through a standardized protocol. EXPOSURES Receipt of NT. MAIN OUTCOMES AND MEASURES Achievement of pancreatic resection at surgical exploration after the receipt of NT. RESULTS Of the 193 patients with complete radiologic imaging available after NT, 96 (49.7%) were women; mean (SD) age at diagnosis was 64 (11) years. Most patients received combined therapy with fluorouracil, irinotecan, oxaliplatin, leucovorin, and folic acid (124 [64.2%]) and 86 (44.6%) received chemoradiotherapy as well. The median interval between pre-NT and post-NT imaging was 6 months (interquartile range [IQR], 4-7 months). All body compartments significantly changed. The adipose compound decreased (median total adipose tissue area from 284.0 cm2; IQR, 171.0-414.0

Published
2018

16. L’elettrochemioterapia nel trattamento delle metastasi ossee

Author

CAMPANACCI, Laura, Bianchi G, Sambri A, Tedesco G, Fini M, Tschon M, Gasbarrini A, and Campanacci L, Bianchi G, Sambri A, Tedesco G, Fini M, Tschon M, Gasbarrini A

Subjects
elettrochemioterapia, metastasi ossee
Abstract

Riportiamo l’esperienza pre-clinica e clinica nel trattamento delle metastasi scheletriche mediante elettrochemioterapia. Sono stati trattati 30 pazienti affetti da metastasi scheletriche con una significativa riduzione del dolore nell’84% dei casi. Le evidenze pre-cliniche e l’esperienza clinica supportano l’impiego dell’elettrochemioterapia nel trattamento delle metastasi ossee. La scelta del candidato che maggiormente può beneficiare del trattamento è multidisciplinare e deve considerare non solo le caratteristiche del paziente ma anche le diverse possibilità terapeutiche disponibili, i loro limiti e le loro percentuali di successo.

Published
2017

17. Synthesis and structure-activity relationship of new 1,5 benzodiazepine CCK-B antagonists

Author

Gaviraghi, G., primary, Cassarà, P., additional, Corsi, M., additional, Curotto, G., additional, Donati, D., additional, Feriani, A., additional, Finch, H., additional, Finizia, G., additional, Pentassuglia, G., additional, Polinelli, S., additional, Ratti, E., additional, Reggiani, A., additional, Tarzia, G., additional, Tedesco, G., additional, Tranquillini, M.E., additional, Trist, D.G., additional, and Ursini, A., additional

Published
1996
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23. The impact of SARS-CoV-2 pandemic on Oncologic and Degenerative Spine Surgery Department activity: the experience of Rizzoli Orthopaedic Institute under COVID-19 lockdown.

Author

GHERMANDI, R., PIPOLA, V., TERZI, S., TEDESCO, G., CAVALLARI, C., BANDIERA, S., BRÒDANO, G. BARBANTI, EVANGELISTI, G., GIROLAMI, M., and GASBARRINI, A.

Abstract

OBJECTIVE: Experience of Department of Oncologic and Degenerative Spine Surgery of Rizzoli Orthopaedic Institute during SARS-CoV-2 pandemic lockdown. PATIENTS AND METHODS: Retrospective observational study of surgically treated patients from 09th March 2020 to 04th May 2020. Data collected: age, sex, type of disease, neurological status, days of hospitalization, complications and type of discharge. A comparison analysis with same period of the last year was performed in order to evaluate the impact of COVID-19 spreading on daily surgical activity. RESULTS: A total of 107 surgical procedures in 102 patients were performed from 09th March 2020 to 04th May 2020. Analysis showed a statistically significant difference in age, sex, ASIA class and type of treated disease compared to the same period of the last year (p=0.042, 0.006, 0.022 and 0.007, respectively). No statistically significant differences were observed in type of discharge, length of hospitalization and complications (p= 0.447, 0.261 and 0.127, respectively). 3 COVID-19 infections have been identified in hospitalized patients. 1 COVID-19 patient wad admitted from Emergency Department and was managed according to a dedicated path. CONCLUSIONS: Surgical activity was paradoxically increased during SARS-CoV-2 pandemic lockdown through the management of urgent and non-deferrable spinal disease with a low rate (3,9%) of COVID-19 infections. [ABSTRACT FROM AUTHOR]

Published
2020

24. Wall proteins of Vitis vinifera pollen I. Constancy of the phenotype

Author

Cargnello, G., Gianazza, Elisabetta, Tedesco, G., Capella, Mariella, and Gerola, F. M.

Subjects
fungi, food and beverages
Abstract

Isoelectric focusing of buffer-soluble wall proteins from pollen grains is suggested for the characterization of different Vitis vinifera cultivars. The protein pattern includes several tens of bands, most of which common to all samples. A few clone-specific components are identified, whose expression is stable over time and independent from the influence of environment., VITIS - Journal of Grapevine Research, Vol. 27 No. 1 (1988): VITIS

Published
2015
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25. Wall proteins of Vitis vinifera pollen II. Influence of environment and rootstock on the electrophoretic pattern

Author

Tedesco, G., Gianazza, Elisabetta, Arrigotti, S., and Cargnello, G.

Subjects
fungi, food and beverages
Abstract

Soluble wall proteins from Vitis vinifera pollen are genotypically determined and their expression, if not the extent of their expression, is independent from external factors. After we had previously observed that the time of sample collection does not influence their electrophoretic pattern, we demonstrate in the present work that this is true also for environment where the vine is growing and for the rootstock on which the scion is grafted., VITIS - Journal of Grapevine Research, Vol. 28 No. 2 (1989): VITIS

Published
2015
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27. Vitis vinifera - a chemotaxonomic approach: Pollen wall proteins

Author

Tedesco, G., Cargnello, G., Zanardini, E., Villa, P., Manini, F., and Gianazza, E.

Subjects
food and beverages
Abstract

The electrophoretic pattern of the pollen wall proteins from clones of cv. Nebbiolo grown in different areas show a geographical clustering. Vermentino, Pigato and Favorita are found virtually identical both by morphological and biochemical criteria., VITIS - Journal of Grapevine Research, Vol. 29 (1990): Vitis (Special Issue)

Published
2015
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28. Vitis vinifera - a chemotaxonomic approach: Anthocyanins in the skin

Author

Mattivi, F., Scienza, A., OSVALDO FAILLA, Villa, P., Anzani, R., Tedesco, G., Gianazza, E., and Righetti, P.

Subjects
Settore CHIM/10 - CHIMICA DEGLI ALIMENTI
Abstract

The gaining of new knowledge about varietal differences in grapevines can be useful for the designing of genetic improvement programs. More and more, chemical methods complement ampelographic ones in the study of variability in grapevines. This work is aimed at the anthocyanin profiling of red-coloured grapes, of which ca. 120 cultivars were sampled; among these there were a high number of old Italian vines and 30 Vitis vinifera ssp. silvestris originating from different areas of Italy. Anthocyanins were HPLC separated and quantified with the aid of an inverse phase microbore column and a photodiode detector. Grapevines were numerically separated in groups using as indexes the percentage of the 5 monoglucosides present, the summations of: acetic esters; malvidin-3-monoglucoside-caffeoate plus all 5 p-coumaric esters; as well as a series of relations correlated to certain enzymatic activities necessary for the esterification of glucosides, hydroxylation and methylation in the biosynthesis of several anthocyanins. Data derived from the study of indexes of varietal enzymatic activity enable us to qualify differences between grapevines linked to the synthesis of anthocyanins. The stability of anthocyanic profiles within the same grape variety enables the use of this technique for taxonomic purposes. This research study discusses the use of this technique for classification and analysis of grape phylogenesis. An in-depth look into the relations between cultivated and wild varieties is given., VITIS - Journal of Grapevine Research, Vol. 29 (1990): Vitis (Special Issue)

Published
2015
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29. A chemotaxonomic investigation on Vitis vinifera 1. Within-cultivar population analysis

Author

Tedesco, G., Scienca, A., Villa, P., Saino, N., Magenes, Stefania, Ettori, Claudia, and Gianazza, Elisabetta

Subjects
food and beverages
Abstract

The extent of variability for storage protein subunits as well as the isozymes of AcP, EST and PGM was evaluated by isoelectric focusing on a large number of individual self-pollinated seeds from cvs Chardonnay, Sangiovese and Traminer. Extracts from 35 randomly selected kernels gave reproducible protein patterns and may thus be taken as representative of the average genetic make-up in a given biotype., VITIS - Journal of Grapevine Research, Vol. 30 No. 2 (1991): Vitis

Published
2015
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30. A chemotaxonomic investigation on Vitis vinifera L. II. Comparison among ssp. sativa traditional cultivars and wild biotypes of ssp. silvestris from various Italian regions

Author

Scienza, A., Villa, P., Tedesco, G., Parini, Licia, Ettori, Claudia, Magenes, Stefania, and Gianazza, Elisabetta

Abstract

An extensive screening on regional representatives of Vitis vinifera ssp. sativa and silvestris was carried out to look for relationships and differences between different taxa. Total proteins in the pH range 4.0-5.5, and the enzymes AcP, ADH, EST, G-6-PDH, MDH, PGM and POD were recorded. Only patterns of storage protein subunits, AcP, EST and G-6-PDH were taxonomically informative. Dendrograms were computerized on the basis of presence/absence of individual bands; these always distinguish at different levels in homogeneous groups between ssp. sativa and ssp. silvestris. The acidic subunits showed a dichotomy from the first branching of the cladogram. These observations are a demonstration that neither hypotheses of direct or indirect origin of the Italian ssp. sativa from Italian ssp. silvestris via domestication is tenanble. The authors suggest that, the morphological, the ecological and the biochemical differences between the two taxa support the hypothesis that V. sativa and V. silvestris should be regarded as two separate taxa that have had reciprocal interactions such a long period of time that a precise location of origin is no longer possible., VITIS - Journal of Grapevine Research, Vol. 33 No. 4 (1994): Vitis

Published
2015
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33. Tumori renali: esperienza trentennale monoistituzionale

Author

Indolfi P, Martinelli I, Ficociello C, Bottigliero G, Fiano P, Barone C, Di Pinto D, Pota E, Di Martino M, Indolfi C, Pecoraro G, Tedesco G, Savarese R, CASALE, Fiorina, PERROTTA, Silverio, Indolfi, P, Perrotta, Silverio, Martinelli, I, Ficociello, C, Bottigliero, G, Fiano, P, Barone, C, Di Pinto, D, Pota, E, Di Martino, M, Indolfi, C, Pecoraro, G, Tedesco, G, Savarese, R, and Casale, Fiorina

Published
2012

34. Prognostic value of splenectomy and lymph-node dissection during gastric cancer resection

Author

TAMMARO V, CARLOMAGNO N, LOMBARI P, TEDESCO G, RENDA, ANDREA, Tammaro, V, Carlomagno, N, Lombari, P, Tedesco, G, and Renda, Andrea

Abstract

Gastric carcinoma is the second most common cause of digestive tumour-related death in Europe, North America and Asia. Today, the gold standard of treatment is still surgery, but outcomes to date are unsatisfactory. The Japanese Society for Research in Gastric Cancer (JSRGC) recommends the routine execution of splenectomy during gastrectomy. This recommendation is contested by western Authors because of increased morbidity and mortality without any real advantage in terms of survival. Patients treated for gastric cancer in our department between 1993 and 2002 were selected for this study. The 132 patients recruited were divided into two groups: a) those treated for gastric cancer without splenectomy; and b) those in whom splenectomy was performed in conjunction with gastrectomy. We analysed: the extent of lymph node dissection, the execution of the splenectomy, and the prognostic importance of factors relating to the patient, tumour and surgeon. Splenectomy was not associated with any increase in morbidity. Complications, especially of the septic type, and perioperative mortality were similar in both groups, and the same was true of survival at both 3 and 5 years. In our opinion, splenectomy should not be routinely combined with surgery for gastric cancer but could be considered for T3-T4 neoplasms or those localized in the upper two thirds of the stomach.

Published
2006

40. Tumori colo-rettali in pazienti HIV positivi: la nostra esperienza

Author

Borrelli A., Tedesco G., Ciolli M.G., BRACALE, UMBERTO, DODARO, CONCETTA ANNA, RENDA, ANDREA, Borrelli, A., Bracale, Umberto, Tedesco, G., Ciolli, M. G., Dodaro, CONCETTA ANNA, and Renda, Andrea

Abstract

Dall’analisi della Letteratura in accordo con la nostra esperienza risulta evidente che nei paziente HIV positivi l’età di insorgenza della neoplasia e’ precoce e la prognosi infausta rispetto ai pazienti HIV negativi. Le misure terapeutiche adottate negli ultimi anni hanno dimostrato un prolungamento e miglioramento della qualità della vita, pertanto al fine di poter fornire un’ assistenza ottimale è necessario anche effettuare uno screenig dei soggetti affetti e/o a rischio non solo rivolto verso le infezioni secondarie ma anche alla diagnosi precoce di neoplasie correlate.

Published
2004

41. Conservative versus surgical treatment of osteogenesis imperfecta: a retrospective analysis of 29 patients

Author

Chiarello E, Donati D, Tedesco G, Cevolani L, Frisoni T, Matteo Cadossi, Hoque M, Spazzoli B, Giannini S, E. Chiarello, D. Donati, G. Tedesco, L. Cevolani, T. Frisoni, M. Cadossi, M. Hoque, B. Spazzoli, and S. Giannini

Subjects
stomatognathic system, surgical treatment, Original Article, osteogenesis imperfecta
Abstract

The aim of our study was to compare the surgical and conservative treatment of patients affected by fragility fractures and deformities of long bones in osteogenesis imperfecta (OI).Our series consisted of 29 consecutive OI patients treated at our Institute. The series comprised 14 females and 15 males of different ages. The mean age at the time of the first treatment was 8 years (median 6 years; SD ± 15; range 1 to 75). The mean follow-up was 88 months. The Sillence classification was used to classify OI. Fifteen patients were classified as Type I; five as Type III and nine as Type IV.A total number of 245 procedures were recorded. Of these, 147 were surgical (pinning; intramedullary nailing and plating) while 98 were conservative (cast, braces and bandages). Bisphosphonate use was a major variable in the study. Clinical charts and radiographic films were analyzed for complications (delayed union, nonunion, malunion, hardware loosening). We recorded 58 complications: 13 in Type I; 28 in Type III and 17 in Type IV OI. The rate of each complication was: 15/245 nonunions (6.1%), 14/245 delayed unions (5.7%), 14/245 malunions (5.7%) and 15/245 hardware loosenings (6.1%).We found no statistically significant differences between surgical and conservative treatments. Type III OI, which is a very crippling form of the disease, was associated with radiographically poorer results than the other types. In our analysis, the two groups were unbalanced and only five patients were treated with bisphosphonates. Nevertheless, bisphosphonate use can be considered a good adjuvant to both the conservative and surgical treatment of OI in order to reduce the rate of complications.

Published
2012

43. Osteosynthetic improvement of osteoporotic bone: prevention surgery

Author

Giannini S, Luciani D, Chiarello E, Matteo Cadossi, Tedesco G, Hoque M, Gnudi S, S. Giannini, D. Luciani, E. Chiarello, M. Cadossi, G. Tedesco, M Hoque, and S. Gnudi

Subjects
prevention, hip fracture, osteoporosis
Abstract

A prior osteoporotic femoral neck fracture (FNF) doubles the risk of a second, contralateral hip fracture. Pharmacological prevention of osteoporotic fractures is cost-effective but medication compliance and persistence rates are suboptimal.The aim of our study was to evaluate the safety and effectiveness of a device developed for the surgical prevention of an additional contralateral FNF in elderly osteoporotic patients.Only patients with a T score ≤ -2.5 were enrolled and randomized either to receive (Group A) or not receive (Group B) surgical prevention. Sixty-seven patients were enrolled. The mean follow-up was 16 months (range 1 to 22). To date, no contralateral FNF has been reported in either group. In Group A, no device-related complications were recorded. Twelve patients reported one or more falls and in four cases a non-femoral fragility fracture occurred.The main problem with pharmacological prevention is therapy adherence and the extensive period needed for only a slight improvement in bone strength.Surgical prevention is a potential solution for avoiding the occurrence of a second contralateral FNF. Nevertheless, a longer follow-up and a larger cohort of patients is necessary in order to verify the true effectiveness of the surgical prevention in elderly osteoporotic patients.

Published
2011

47. Quality in emergency departments: a study on 3,285,440 admissions

Author

Sartini, M, Cremonesi, P, Tamagno, R, Cristina, Ml, Orlando, P, Simeu, Group, Vandelli, A, Carinci, A, Caruso, A, Grotti, A, Iacovella, A, La Brocca, A, Mangioncalda, A, Longanesi, Am, Susi, B, Barletta, C, Braglia, D, Coen, D, Tazza, D, Gottardi, E, Palego, E, Urbano, E, Bar, F, Bussani, F, De Giorgi, F, Esposito, F, Fabi, F, Lotti, F, Miglio, F, Moscariello, F, Pertoldi, F, Sardella, F, Tosato, F, Abregal, G, Baldi, G, Carbone, G, Cerqua, G, Giagnorio, G, Pia, G, Piazza, G, Tedesco, G, Sallustio, Gf, Morana, I, Beringheli, L, Jannotti, L, Spinsi, L, Zulli, L, Cavazza, M, De Simone, M, Galletti, M, Gioffre', Maria, Greco, M, Longoni, M, Luppi, M, Magnani, M, Mazzone, M, Pastorello, M, Pazzaglia, M, Ravaglia, M, Zammataro, M, Zanna, M, Bressan, Ma, Saggese, Mp, Gentiloni Silveri, N, Scopetta, N, De Mitri, O, Fantin, O, Boscolo, P, Cancemi, P, De Angelis, P, Di Pietro, P, Mosca, P, Pacelli, P, Torboli, P, Copetti, R, Fazio, R, Losordo, R, Melandri, R, Papitto, R, Chiaravalle, S, Orlando, S, Sturlese, U, Di Grande, A, Narbone, G, Zimmermann, H, Martinelli, L, Clanchini, V, Paternosto, D, Fiorilli, M, Del Prato, C, Becheri, M, Lanigra, M, Guerra, G, Sinno, C, Soragna, A, Ferranio, Mp, Bua, V, Capra, R, and Lualdi, E.

Subjects
Italian Emergency Departments Quality Multi-centre study, Patient Admission, Italy, Health Care Surveys, Humans, Triage, Emergency Service, Hospital, Quality of Health Care
Abstract

A multi-centre study has been conducted, during 2005, by means of a questionnaire posted on the Italian Society of Emergency Medicine (SIMEU) web page. Our intention was to carry out an organisational and functional analysis of Italian Emergency Departments (ED) in order to pick out some macro-indicators of the activities performed. Participation was good, in that 69 ED (3,285,440 admissions to emergency services) responded to the questionnaire.The study was based on 18 questions: 3 regarding the personnel of the ED, 2 regarding organisational and functional aspects, 5 on the activity of the ED, 7 on triage and 1 on the assessment of the quality perceived by the users of the ED.The replies revealed that 91.30% of the ED were equipped with data-processing software, which, in 96.83% of cases, tracked the entire itinerary of the patient. About 48,000 patients/year used the ED: 76.72% were discharged and 18.31% were hospitalised. Observation Units were active in 81.16% of the ED examined. Triage programmes were in place in 92.75% of ED: in 75.81% of these, triage was performed throughout the entire itinerary of the patient; in 16.13% it was performed only symptom-based, and in 8.06% only on-call. Of the patients arriving at the ED, 24.19% were assigned a non-urgent triage code, 60.01% a urgent code, 14.30% a emergent code and 1.49% a life-threatening code. Waiting times were: 52.39 min for non-urgent patients, 40.26 min for urgent, 12.08 for emergent, and 1.19 for life-threatening patients.

Published
2007

48. Quality in Emergency Department: a study on 3,285,440 admissions

Author

Sartini, Marina, Cremonesi, P., Tamagno, R., Cristina, MARIA LUISA, Orlando, Paolo, Vandelli, A., Carinci, A., Caruso, A., Grotti, A., Iacovella, A., LA BROCCA, A., Mangioncalda, A., Longanesi, A. M., Susi, B., Barletta, C., Braglia, D., Coen, D., Tazza, D., Gottardi, E., Palego, E., Urbano, E., Bar, F., Bussani, F., DE GIORGI, F., Esposito, F., Fabi, F., Lotti, F., Miglio, F., Moscariello, F., Pertoldi, F., Sardella, F., Tosato, F., Abregal, G., Baldi, G., Carbone, G., Cerqua, G., Giagnorio, G., Pia, G., Piazza, G., Tedesco, G., Sallustio, G. F., Morana, I., Beringheli, L., Jannotti, L., Spinsi, L., Zulli, L., Cavazza, M., DE SIMONE, M., Galletti, M., GIOFFRÈ FLORIO, M., Greco, M., Longoni, M., Luppi, M., Magnani, M., Mazzone, M., Pastorello, M., Pazzaglia, M., Ravaglia, M., Zammataro, M., Zanna, M., Bressan, M. A., Saggese, M. P., GENTILONI SILVERI, N., Scopetta, N., DE MITRI, O., Fantin, O., Boscolo, P., Cancemi, P., DE ANGELIS, P., DI PIETRO, P., Mosca, P., Pacelli, P., Torboli, P., Copetti, R., Fazio, R., Losordo, R., Melandri, R., Papitto, R., Chiaravalle, S., Orlando, S., Sturlese, U., DI GRANDE, A., Narbone, G., Zimmermann, H., Martinelli, L., Clanchini, V., Paternosto, D., Fiorilli, M., DEL PRATO, C., Becheri, M., Lanigra, M., Guerra, G., Sinno, C., Soragna, A., Ferranio, M. P., Bua, V., Capra, R., and Lualdi, E.

Published
2007

49. Studio Osservazionale Multicentrico

Author

Cremonesi, P, Sartini, M, Tamagno, R, Randelli, A, Orlando, P, Gruppo Simeu: Carinci, A, Caruso, A, Grotti, A, Iacovella, A, La Brocca, A, Mangiocalda, A, Longanesi, Am, Susi, B, Barletta, C, Braglia, D, Coen, D, Tazza, D, Gottardi, E, Palego, E, Urbano, E, Bar, F, Bussani, F, De Giori, F, Esposito, F, Fabi, F, Lotti, F, Miglio, F, Moscariello, F, Pertoldi, F, Sardella, F, Tosato, F, Abregal, G, Baldi, G, Carbone, G, Cerqua, G, Giagnorio, G, Pia, G, Piazza, G, Tedesco, G, Sallustio, Gf, Morana, I, Berigheli, L, Jannotti, L, Spinsi, L, Zulli, L, Cavazza, M, De Simone, M, Galletti, M, Gioffre', Maria, Greco, M, Longoni, M, Luppi, M, Magnani, M, Mazzone, M, Pastorello, M, Pazzaglia, M, Ravaglia, M, Zammataro, M, Zanna, M, Bressan, Ma, Maggese, Mp, Gentiloni Silveri, N, Scopetta, N, De Mitri, O, Fantin, O, Boscolo, P, Cancemi, P, De Angelis, P, Di Pietro, P, Mosca, P, Pacelli, P, Torboli, P, Copetti, R, Fazio, R, Lo Sordo, R, Melandri, R, Papitto, R, Chiaravalle, S, Orlando, S, and Sturlese, U.

Published
2004

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