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5 results on '"Tedesco C. C."'

1. Mercaptoalbumin Is Associated with Graft Patency in Patients Undergoing Coronary Artery Bypass Grafting

Author

Brioschi, M, Gianazza, E, Andreini, D, Mushtaq, S, Cavallotti, L, Veglia, F, Tedesco, C, Colombo, G, Pepi, M, Polvani, G, Tremoli, E, Parolari, A, Banfi, C, Brioschi M., Gianazza E., Andreini D., Mushtaq S., Cavallotti L., Veglia F., Tedesco C. C., Colombo G. I., Pepi M., Polvani G., Tremoli E., Parolari A., Banfi C., Brioschi, M, Gianazza, E, Andreini, D, Mushtaq, S, Cavallotti, L, Veglia, F, Tedesco, C, Colombo, G, Pepi, M, Polvani, G, Tremoli, E, Parolari, A, Banfi, C, Brioschi M., Gianazza E., Andreini D., Mushtaq S., Cavallotti L., Veglia F., Tedesco C. C., Colombo G. I., Pepi M., Polvani G., Tremoli E., Parolari A., and Banfi C.

Abstract

Coronary artery bypass graft (CABG) surgery still represents the gold standard for patients with complex multivessel coronary artery disease. However, graft occlusion still occurs in a significant proportion of CABG conduits, and oxidative stress is currently considered to be a potential contributor. Human serum albumin (HSA) represents the main antioxidant in plasma through its reduced amino acid Cys34, which can efficiently scavenge several oxidants. In a nested case-control study including 36 patients with occluded grafts and 38 age- and sex-matched patients without occlusion, we assessed the levels of the native mercaptoalbumin (HSA-SH) and oxidized thiolated form of albumin (Thio-HSA) in relation with graft occlusion within 5 years after CABG. We found that the plasma level of preoperative HSA-SH was significantly lower in patients with occluded graft at 5 years follow-up than in patients with graft patency. Furthermore, low HSA-SH remained independently associated with graft occlusion even after adjusting for preoperative D-dimer, a well-known marker of activated coagulation recently found to be associated with graft occlusion. In conclusion, the preoperative level of HSA-SH is independently associated with graft occlusion in CABG and represents a measurable and potentially druggable predictor.

Published
2022

2. Potential relation between plasma bdnf levels and human coronary plaque morphology

Author

Amadio, P., Cosentino, N., Eligini, S., Barbieri, S., Tedesco, C. C., Sandrini, L., Zara, M., Fabiocchi, F., Niccoli, Giampaolo, Magnani, G., Fracassi, Francesco, Crea, Filippo, Veglia, F., Marenzi, Giancarlo, Barbieri, S. S., Niccoli G. (ORCID:0000-0002-3187-6262), Fracassi F., Crea F. (ORCID:0000-0001-9404-8846), Marenzi G., Amadio, P., Cosentino, N., Eligini, S., Barbieri, S., Tedesco, C. C., Sandrini, L., Zara, M., Fabiocchi, F., Niccoli, Giampaolo, Magnani, G., Fracassi, Francesco, Crea, Filippo, Veglia, F., Marenzi, Giancarlo, Barbieri, S. S., Niccoli G. (ORCID:0000-0002-3187-6262), Fracassi F., Crea F. (ORCID:0000-0001-9404-8846), and Marenzi G.

Abstract

Coronary artery disease (CAD) patients are at high ischemic risk, and new biomarkers reflecting atherosclerotic disease severity and coronary plaque vulnerability are required. The Brain-Derived Neurotrophic Factor (BDNF) affects endothelial and macrophage activation suggesting its involvement in atherosclerotic plaque behavior. To investigate whether plasma BDNF is associated with in vivo coronary plaque features, assessed by optical coherence tomography (OCT), in both acute myocardial infarction (AMI) and stable angina (SA) patients, we enrolled 55 CAD patients (31 SA and 24 AMI), and 21 healthy subjects (HS). BDNF was lower in CAD patients than in HS (p < 0.0001), and it decreased with the presence, clinical acuity and severity of CAD. The greater BDNF levels were associated with OCT features of plaque vulnerability in overall CAD as well as in SA and AMI patients (p < 0.03). Specifically, in SA patients, BDNF correlated positively with macrophages’ infiltration within atherosclerotic plaque (p = 0.01) and inversely with minimal lumen area (p = 0.02). In AMI patients a negative correlation between BDNF and cap thickness was found (p = 0.02). Despite a small study population, our data suggest a relationship between BDNF and coronary plaque vulnerability, showing that vulnerable plaque is positively associated with plasma BDNF levels, regardless of the clinical CAD manifestation.

Published
2021

3. Analysis of the genetic variants associated with circulating levels of sgp130. Results from the IMPROVE study

Author

Bonomi, A., Veglia, F., Baldassarre, D., Strawbridge, R. J., Golabkesh, Z., Sennblad, B., Leander, K., Smit, A. J., Giral, P., Humphries, S. E., Tremoli, E., Hamsten, A., de Faire, U., Gigante, B., Sirtori, C. R., Castelnuovo, S., Calabresi, L., Amato, M., Frigerio, B., Ravani, A., Sansaro, D., Coggi, D., Tedesco, C. C., Eriksson, P., Silveira, A., Laguzzi, F., Cooper, J., Acharya, J., Huttunen, K., Rauramaa, E., Pekkarinen, H., Penttila, I. M., Torronen, J., Rauramaa, R., van Gessel, A. I., van Roon, A. M., Teune, G. C., Kuipers, W. D., Bruin, M., Nicolai, A., Haarsma-Jorritsma, P., Mulder, D. J., Bilo, H. J. G., Smeets, G. H., Beaudeux, J. L., Kahn, J. F., Carreau, V., Kontush, A., Karppi, J., Nurmi, T., Nyyssonen, K., Salonen, R., Tuomainen, T. P., Tuomainen, J., Kauhanen, J., Kurl, S., Vaudo, G., Alaeddin, A., Siepi, D., Lupattelli, G., Mannarino, E., Groningen Kidney Center (GKC), Lifestyle Medicine (LM), and Translational Immunology Groningen (TRIGR)

Subjects
Male, Carotid Intima-Media Thickness, Polymorphism, Single Nucleotide, INTIMA-MEDIA THICKNESS, Article, Gene Frequency, Risk Factors, Cytokine Receptor gp130, Humans, Genetic Predisposition to Disease, POPULATION, Aged, Medicinsk genetik, RISK, VASCULAR EVENTS, Interleukin-6, GENOME-WIDE, Genetic Variation, SIGNAL TRANSDUCER GP130, Middle Aged, Atherosclerosis, POLYMORPHISM, Genetic Loci, INTERLEUKIN-6 RECEPTOR, SOLUBLE GP130, Cytokines, Female, Medical Genetics, 4 SUBUNITS, Biomarkers
Abstract

The genes regulating circulating levels of soluble gp130 (sgp130), the antagonist of the inflammatory response in atherosclerosis driven by interleukin 6, are largely unknown. Aims of the present study were to identify genetic loci associated with circulating sgp130 and to explore the potential association between variants associated with sgp130 and markers of subclinical atherosclerosis. The study is based on IMPROVE (n = 3703), a cardiovascular multicentre study designed to investigate the determinants of carotid intima media thickness, a measure of subclinical atherosclerosis. Genomic DNA was genotyped by the CardioMetaboChip and ImmunoChip. About 360,842 SNPs were tested for association with log-transformed sgp130, using linear regression adjusted for age, gender, and population stratification using PLINK v1.07. A p value of 1 × 10−5 was chosen as threshold for significance value. In an exploratory analysis, SNPs associated with sgp130 were tested for association with c-IMT measures. We identified two SNPs significantly associated with sgp130 levels and 24 showing suggestive association with sgp130 levels. One SNP (rs17688225) on chromosome 14 was positively associated with sgp130 serum levels (β = 0.03 SE = 0.007, p = 4.77 × 10−5) and inversely associated with c-IMT (c-IMTmean–max β = −0.001 SE = 0.005, p = 0.0342). Our data indicate that multiple loci regulate sgp130 levels and suggest a possible common pathway between sgp130 and c-IMT measures.

Published
2020

4. Permanent atrial fibrillation affects exercise capacity in chronic heart failure patients

Author

Agostoni, P., primary, Emdin, M., additional, Corra, U., additional, Veglia, F., additional, Magri, D., additional, Tedesco, C. C., additional, Berton, E., additional, Passino, C., additional, Bertella, E., additional, Re, F., additional, Mezzani, A., additional, Belardinelli, R., additional, Colombo, C., additional, La Gioia, R., additional, Vicenzi, M., additional, Giannoni, A., additional, Scrutinio, D., additional, Giannuzzi, P., additional, Tondo, C., additional, Di Lenarda, A., additional, Sinagra, G., additional, Piepoli, M. F., additional, and Guazzi, M., additional

Published
2008
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5. Soluble Receptor for Advanced Glycation End-products regulates age-associated Cardiac Fibrosis

Author

Calogero C. Tedesco, Fabrizio Veglia, Giovanni Pezone, Marco Bianchi, Francesco Scavello, Giulio Pompilio, Federica Macrì, Gualtiero I. Colombo, Estella Zuccolo, Stefania Castiglione, Alessandro Scopece, Giuseppina Milano, Laura Popolo, Angela Raucci, Patrizia Nigro, Elisa Gambini, Filippo Zeni, Genny Degani, Scavello, F., Zeni, F., Milano, G., Macri, F., Castiglione, S., Zuccolo, E., Scopece, A., Pezone, G., Tedesco, C. C., Nigro, P., Degani, G., Gambini, E., Veglia, F., Popolo, L., Pompilio, G., Colombo, G. I., Bianchi, M. E., and Raucci, A.

Subjects
Cardiac function curve, medicine.medical_specialty, Aging, Cardiac fibrosis, Receptor for Advanced Glycation End Products, heart failure, Heart failure, Applied Microbiology and Biotechnology, RAGE (receptor), Cell Line, Transforming Growth Factor beta1, SRAGE, Mice, Fibrosis, Glycation, Internal medicine, medicine, Animals, Humans, Protein Isoforms, Receptor, Molecular Biology, Ecology, Evolution, Behavior and Systematics, Cardiac remodeling, business.industry, Myocardium, fibrosis, Cell Biology, Fibroblasts, medicine.disease, Actins, Mice, Inbred C57BL, Endocrinology, cardiovascular system, Female, cardiac remodeling, business, Developmental Biology, Transforming growth factor, Research Paper, sRAGE
Abstract

Myocardial aging increases the cardiovascular risk in the elderly. The Receptor for Advanced Glycation End-products (RAGE) is involved in age-related disorders. The soluble isoform (sRAGE) acts as a scavenger blocking the membrane-bound receptor activation. This study aims at investigating RAGE contribution to age-related cardiac remodeling. We analyzed the cardiac function of three different age groups of female Rage-/- and C57BL/6N (WT) mice: 2.5- (Young), 12- (Middle-age, MA) and 21-months (Old) old. While aging, Rage-/- mice displayed an increase in left ventricle (LV) dimensions compared to age-matched WT animals, with the main differences observed in the MA groups. Rage-/- mice showed higher fibrosis and a larger number of α-Smooth Muscle Actin (SMA)+ cells with age, along with increased expression of pro-fibrotic Transforming Growth Factor (TGF)-β1 pathway components. RAGE isoforms were undetectable in LV of WT mice, nevertheless, circulating sRAGE declined with aging and inversely associated with LV diastolic dimensions. Human cardiac fibroblasts stimulated with sRAGE exhibited a reduction in proliferation, pro-fibrotic proteins and TGF-beta Receptor 1 (TGFbR1) expression and Smad2-3 activation. Finally, sRAGE administration to MA WT animals reduced cardiac fibrosis. Hence, our work shows that RAGE associates with age-dependent myocardial changes and indicates sRAGE as an inhibitor of cardiac fibroblasts differentiation and age-dependent cardiac fibrosis.

Published
2021

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