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1. Adjuvant abemaciclib combined with endocrine therapy for high-risk early breast cancer: updated efficacy and Ki-67 analysis from the monarchE study

Author

Jimenez, M.M., Johnston, S., Boyle, F., Steger, G.G., Neven, P., Jiang, Z., Campone, M., Huober, J., Shimizu, C., Cicin, I., Wardley, A., Tolaney, S.M., Abuin, G.G., Zarba, J., Lim, E., Sant, P., Liao, N., Christiansen, B., Eigeliene, N., Martin-Babau, J., Ettl, J., Mavroudis, D., Chiu, J., Boer, K., Nagarkar, R., Paluch-Shimon, S., Moscetti, L., Sagara, Y., Kim, S.-B., Maciel, M.M., Tjan-Heijnen, V., Broom, R., Lacko, A., Schenker, M., Volkov, N., Sim Yap, Y., Coccia-Portugal, M., Ángel García Sáenz, J., Andersson, A., Chao, T.-Y., Gokmen, E., Harputluoglu, H., Berzoy, O., Patt, D., McArthur, H., Chew, H., Chalasani, P., Kaufman, P., Tedesco, K., Graff, S.L., Harbeck, N., Rastogi, P., Martin, M., Shao, Z.M., Fasching, P.A., Huang, C.S., Jaliffe, G.G., Tryakin, A., Goetz, M.P., Rugo, H.S., Senkus, E., Testa, L., Andersson, M., Tamura, K., Del Mastro, L., Kreipe, H., Hegg, R., Sohn, J., Guarneri, V., Cortés, J., Hamilton, E., André, V., Wei, R., Barriga, S., Sherwood, S., Forrester, T., Munoz, M., Shahir, A., San Antonio, B., Nabinger, S.C., Toi, M., Johnston, S.R.D., and O’Shaughnessy, J.

Published
2021
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4. Adjuvant abemaciclib combined with endocrine therapy for high-risk early breast cancer: updated efficacy and Ki-67 analysis from the monarchE study

Author

Harbeck, N., primary, Rastogi, P., additional, Martin, M., additional, Tolaney, S.M., additional, Shao, Z.M., additional, Fasching, P.A., additional, Huang, C.S., additional, Jaliffe, G.G., additional, Tryakin, A., additional, Goetz, M.P., additional, Rugo, H.S., additional, Senkus, E., additional, Testa, L., additional, Andersson, M., additional, Tamura, K., additional, Del Mastro, L., additional, Steger, G.G., additional, Kreipe, H., additional, Hegg, R., additional, Sohn, J., additional, Guarneri, V., additional, Cortés, J., additional, Hamilton, E., additional, André, V., additional, Wei, R., additional, Barriga, S., additional, Sherwood, S., additional, Forrester, T., additional, Munoz, M., additional, Shahir, A., additional, San Antonio, B., additional, Nabinger, S.C., additional, Toi, M., additional, Johnston, S.R.D., additional, O’Shaughnessy, J., additional, Jimenez, M.M., additional, Johnston, S., additional, Boyle, F., additional, Neven, P., additional, Jiang, Z., additional, Campone, M., additional, Huober, J., additional, Shimizu, C., additional, Cicin, I., additional, Wardley, A., additional, Abuin, G.G., additional, Zarba, J., additional, Lim, E., additional, Sant, P., additional, Liao, N., additional, Christiansen, B., additional, Eigeliene, N., additional, Martin-Babau, J., additional, Ettl, J., additional, Mavroudis, D., additional, Chiu, J., additional, Boer, K., additional, Nagarkar, R., additional, Paluch-Shimon, S., additional, Moscetti, L., additional, Sagara, Y., additional, Kim, S.-B., additional, Maciel, M.M., additional, Tjan-Heijnen, V., additional, Broom, R., additional, Lacko, A., additional, Schenker, M., additional, Volkov, N., additional, Sim Yap, Y., additional, Coccia-Portugal, M., additional, Ángel García Sáenz, J., additional, Andersson, A., additional, Chao, T.-Y., additional, Gokmen, E., additional, Harputluoglu, H., additional, Berzoy, O., additional, Patt, D., additional, McArthur, H., additional, Chew, H., additional, Chalasani, P., additional, Kaufman, P., additional, Tedesco, K., additional, and Graff, S.L., additional

Published
2021
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5. Executive Summary. Second State of the Carbon Cycle Report

Author

Birdsey, R., primary, Mayes, M. A., additional, Romero-Lankao, P., additional, Najjar, R., additional, Reed, S. C., additional, Cavallaro, N., additional, Shrestha, G., additional, Hayes, D. J., additional, Lorenzoni, L., additional, Marsh, A., additional, Tedesco, K., additional, Wirth, T., additional, and Zhuo, Z., additional

Published
2018
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6. Dr. Robert C. Thunell: A 40‐Year Career of Outstanding Science, Service, and Education in Paleoceanography and Paleoclimatology

Author

Tedesco, K., primary, Tappa, E., additional, Benitez‐Nelson, C., additional, Black, D., additional, Christensen, B., additional, Corliss, B., additional, Goni, M., additional, Lorenzoni, L., additional, McConnell, M., additional, Osborne, E., additional, Pride, C., additional, Sautter, L., additional, and Umling, N., additional

Published
2020
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7. Products from a surface ocean CO2 reference network, SOCONET

Author

Wanninkhof, R., Bakker, D. C. E., Pfeil, B., Smith, K., Hankin, S., Alin, S. R., Cosca, C., Harasawa, S., Kozyr, A., Nojiri, Y., O'Brien, K., Telszewski, M., Tilbrook, B., Wada, C., Akl, J., Barbero, L., Bates, N. R., Boutin, J., Bozec, Y., Cai, W. J., Castle, R. D., Chavez, F. P., Chen, L., Chierici, M., Currie, K., De Baar, H. J. W., Evans, W., Feely, R. A., Fransson, A., Gao, Z., Hales, B., Hardman-Mountford, N. J., Hoppema, Mario, Huang, W.J., Hunt, C. W., Huss, B., Ichikawa, T., Johannessen, T., Jones, E. M., Jones, S. D., Jutterström, S., Kitidis, V., Körtzinger, A., Landschützer, P., Lauvset, S. K., Lefevre, N., Manke, A., Mathis, J. T., Merlivat, L., Metzl, N., Murata, A., Monteiro, P., Newberger, T., Omar, A. M., Ono, T., Park, G. H., Paterson, K., Pierrot, D., Rios, A. F., Sabine, C. L., Saito, S., Salisbury, J., Sarma, V. V. S. S., Schlitzer, Reiner, Sieger, Rainer, Skjelvan, I., Steinhoff, T., Sullivan, K. F., Sun, H., Sutton, A.J., Suzuki, T., Sweeney, C., Takahashi, T., Tjiputra, J., Tsurushima, N., Van Heuven, S. M. A. C., Vandemark, D., Vlahos, P., Wallace, D. W. R., Watson, A., Pickers, P. A., Olsen, A., Stephens, B.B., Munro, D., Rehder, G., Santana-Casiano, J. M., Müller, J. D., Trianes, J., Tedesco, K., Ishii, M., González-Dávila, M., Suntharalingam, P., Nakaoka, S.-i., Schuster, U., Wanninkhof, R., Bakker, D. C. E., Pfeil, B., Smith, K., Hankin, S., Alin, S. R., Cosca, C., Harasawa, S., Kozyr, A., Nojiri, Y., O'Brien, K., Telszewski, M., Tilbrook, B., Wada, C., Akl, J., Barbero, L., Bates, N. R., Boutin, J., Bozec, Y., Cai, W. J., Castle, R. D., Chavez, F. P., Chen, L., Chierici, M., Currie, K., De Baar, H. J. W., Evans, W., Feely, R. A., Fransson, A., Gao, Z., Hales, B., Hardman-Mountford, N. J., Hoppema, Mario, Huang, W.J., Hunt, C. W., Huss, B., Ichikawa, T., Johannessen, T., Jones, E. M., Jones, S. D., Jutterström, S., Kitidis, V., Körtzinger, A., Landschützer, P., Lauvset, S. K., Lefevre, N., Manke, A., Mathis, J. T., Merlivat, L., Metzl, N., Murata, A., Monteiro, P., Newberger, T., Omar, A. M., Ono, T., Park, G. H., Paterson, K., Pierrot, D., Rios, A. F., Sabine, C. L., Saito, S., Salisbury, J., Sarma, V. V. S. S., Schlitzer, Reiner, Sieger, Rainer, Skjelvan, I., Steinhoff, T., Sullivan, K. F., Sun, H., Sutton, A.J., Suzuki, T., Sweeney, C., Takahashi, T., Tjiputra, J., Tsurushima, N., Van Heuven, S. M. A. C., Vandemark, D., Vlahos, P., Wallace, D. W. R., Watson, A., Pickers, P. A., Olsen, A., Stephens, B.B., Munro, D., Rehder, G., Santana-Casiano, J. M., Müller, J. D., Trianes, J., Tedesco, K., Ishii, M., González-Dávila, M., Suntharalingam, P., Nakaoka, S.-i., and Schuster, U.

Published
2020

8. Dr. Robert C. Thunell: A 40-Year Career of Outstanding Science, Service, and Education in Paleoceanography and Paleoclimatology

Author

Tedesco, K., Tappa, E., Benitez-Nelson, C., Black, D., Christensen, B., Corliss, B., Goni, M., Lorenzoni, L., McConnell, M., Osborne, E., Pride, C., Sautter, L., Umling, N., Tedesco, K., Tappa, E., Benitez-Nelson, C., Black, D., Christensen, B., Corliss, B., Goni, M., Lorenzoni, L., McConnell, M., Osborne, E., Pride, C., Sautter, L., and Umling, N.

Published
2020

11. Meltwater along the Arctic margin of the Laurentide Ice Sheet (8-12 ka): stable isotopic evidence and implications for past salinity anomalies

Author

Andrews, J.T., Dyke, A.S., Tedesco, K., and White, J.W.

Subjects
Arctic Coast (Canada) -- Natural history, Glaciology -- Research, Salinity -- Research, Earth sciences
Abstract

We report a new time series of stable isotopic values for the past 12 ka measured in two species of shallow-water marine bivalves collected from raised marine deposits along the coast of Arctic Canada. Each sample (n = 60) had been radiocarbon dated previously. The results indicate that between 11.8 and 10 ka the Delta18O of the shells ranged between 0.25 per thousand and -6 per thousand, but values increased after 9 ka as the flux of meltwater to the Arctic Ocean decreased and as the Canadian Arctic channels opened to allow the present surface circulation to become established. Prior to about 9 ka, glacial meltwaters from the northern margin of the Laurentide Ice Sheet must have been entrained in the surface waters of the Arctic Ocean and directed southward to the North Atlantic through Fram Strait. This source of meltwater must be included in late Quaternary models of forcing of the North Atlantic thermohaline circulation. Glacial isostatic uplift of the sills within the Canadian Arctic channels implies that outflow through Fram Strait increased during the Holocene.

Published
1993

12. Detrital carbonate-rich sediments, northwestern Labrador Sea: implications for ice-sheet dynamics and iceberg rafting (Heirich) events in the North Atlantic

Author

Andrews, J.T. and Tedesco, K.

Subjects
Labrador Sea -- Natural history, North Atlantic Ocean -- Natural history, Carbonates -- Research, Ice sheets -- Research, Icebergs -- Research, Earth sciences
Abstract

Much of the bed of the central and eastern sectors of the Laurentide Ice Sheet was underlain by Paleozoic carbonates. We propose that pulses of detrital carbonate-rich sediments in two cores from the northwestern Labrador Sea reflect episodes when an ice stream from the Hudson Strait extended to the shelf break and delivered sediment onto the slope and deep-sea plain. Atomic mass spectroscopy 14C dating of planktonic foraminifera in cores HU75-009-IV-55 (2.4 km water depth) and HU87-033-009 (1.4 km water depth and 150 km north-northwest), indicates that the youngest event occurred between ca. 14 and 15 ka and another occurred between 19 and 21 ka. The two carbonate intervals in northwestern Labrador Sea cores are coeval with Heinrich events 1 and 2 in the eastern North Atlantic (lat 45 degrees-50 degrees N, long 20 degrees W), where they are associated with an increase in lithic fragments and a drastic reduction in the numbers of foraminifera. These changes have been linked with the massive production of icebergs associated with ice-sheet surges. Our evidence indicates that Heinrich events 1 and 2 are associated with the dynamics of the Hudson Strait ice stream and denote considerable glaciological instability.

Published
1992

13. A surface ocean CO2 reference network, SOCONET and associated marine boundary layer CO2 measurements

Author

Wanninkhof, R., Pickers, P.A., Omar, A. M., Sutton, A., Murata, A., Olsen, A., Stephens, B.B., Tilbrook, B., Munro, D., Pierrot, D., Rehder, G., Santana-Casiano, J.M., Müller, J.D., Trianes, J., Tedesco, K., O'Brien, K., Currie, K., Barbero, L., Telszewski, M., Hoppema, Mario, Ishii, M., González-Dávila, M., Bates, N. R., Metzl, N., Suntharalingam, P., Feely, R. A., Nakaoka, S.-i., Lauvset, S. K., Takahashi, T., Steinhoff, T., Schuster, U., Wanninkhof, R., Pickers, P.A., Omar, A. M., Sutton, A., Murata, A., Olsen, A., Stephens, B.B., Tilbrook, B., Munro, D., Pierrot, D., Rehder, G., Santana-Casiano, J.M., Müller, J.D., Trianes, J., Tedesco, K., O'Brien, K., Currie, K., Barbero, L., Telszewski, M., Hoppema, Mario, Ishii, M., González-Dávila, M., Bates, N. R., Metzl, N., Suntharalingam, P., Feely, R. A., Nakaoka, S.-i., Lauvset, S. K., Takahashi, T., Steinhoff, T., and Schuster, U.

Abstract

The Surface Ocean CO2 NETwork (SOCONET) and atmospheric Marine Boundary Layer (MBL) CO2 measurements from ships and buoys focus on the operational aspects of measurements of CO2 in both the ocean surface and atmospheric MBLs. The goal is to provide accurate pCO2 data to within 2 micro atmosphere (uatm) for surface ocean and 0.2 parts per million (ppm) for MBL measurements following rigorous best practices, calibration and intercomparison procedures. Platforms and data will be tracked in near real-time and final quality-controlled data will be provided to the community within a year. The network, involving partners worldwide, will aid in production of important products such as maps of monthly resolved surface ocean CO2 and air-sea CO2 flux measurements. These products and other derivatives using surface ocean and MBL CO2 data, such as surface ocean pH maps and MBL CO2 maps, will be of high value for policy assessments and socio-economic decisions regarding the role of the ocean in sequestering anthropogenic CO2 and how this uptake is impacting ocean health by ocean acidification. SOCONET has an open ocean emphasis but will work with regional (coastal) networks. It will liaise with intergovernmental science organizations such as Global Atmosphere Watch (GAW), and the joint committee for and ocean and marine meteorology (JCOMM). Here we describe the details of this emerging network and its proposed operations and practices.

Published
2019

14. An open-label, dose-ranging study of Rolontis, a novel long-acting myeloid growth factor, in breast cancer

Author

Vacirca, J., Chan, Arlene, Mezei, K., Adoo, C., Pápai, Z., Mcgregor, K., Okera, M., Horváth, Z., Landherr, L., Hanslik, J., Hager, S., Ibrahim, E., Rostom, M., Bhat, G., Choi, M., Reddy, G., Tedesco, K., Agajanian, R., Láng, I., Schwartzberg, L., Vacirca, J., Chan, Arlene, Mezei, K., Adoo, C., Pápai, Z., Mcgregor, K., Okera, M., Horváth, Z., Landherr, L., Hanslik, J., Hager, S., Ibrahim, E., Rostom, M., Bhat, G., Choi, M., Reddy, G., Tedesco, K., Agajanian, R., Láng, I., and Schwartzberg, L.

Abstract

This randomized, open-label, active-controlled study investigated the safety and efficacy of three doses of Rolontis (eflapegrastim), a novel, long-acting myeloid growth factor, versus pegfilgrastim in breast cancer patients being treated with docetaxel and cyclophosphamide (TC). The primary efficacy endpoint was duration of severe neutropenia (DSN) during the first cycle of treatment. Patients who were candidates for adjuvant/neoadjuvant TC chemotherapy were eligible for participation. TC was administered on Day 1, followed by 45, 135, or 270 µg/kg Rolontis or 6 mg pegfilgrastim on Day 2. Complete blood counts were monitored daily when the absolute neutrophil count (ANC) fell to < 1.5 × 10 9 /L. Up to four cycles of TC were investigated. The difference in DSN (time from ANC < 0.5 × 10 9 /L to ANC recovery =2.0 × 10 9 /L) between the Rolontis and pegfilgrastim groups was -0.28 days (confidence interval [CI]: -0.56, -0.06) at 270 µg/kg, 0.14 days (CI: -0.28, 0.64) at 135 µg/kg, and 0.72 days (CI: 0.19, 1.27) at 45 µg/kg. Noninferiority to pegfilgrastim was demonstrated at 135 µg/kg (P = 0.002) and 270 µg/kg (P < .001), with superiority demonstrated at 270 µg/kg (0.03 days; P = 0.023). The most common treatment-related adverse events (AEs) were bone pain, myalgia, arthralgia, back pain, and elevated white blood cell counts, with similar incidences across groups. All doses of Rolontis were well tolerated, and no new or significant treatment-related toxicities were observed. In Cycle 1, Rolontis demonstrated noninferiority at the 135 µg/kg dose and statistical superiority in DSN at the 270 µg/kg dose when compared to pegfilgrastim.

Published
2018

15. Randomized phase 2, open-label, dose-ranging study of a novel, long-acting G-CSF (SPI-2012) or pegfilgrastim for the management of neutropenia in patients with breast cancer (BC) treated with (Neo) adjuvant chemotherapy with docetaxel + cyclophosphamide (TC)

Author

Vacirca, J. L., Chan, A., Mezei, K., Adoo, C. S., Pápai, Zsuzsanna, McGregor, K., Okera, M., Horváth, Zsolt, Landherr, László, Hanslik, J., Hager, S. J., Ibrahim, E. N., Ghazal, H., Rostom, M., Bhat, G., Choi, M. R., Allen, L. F., Tedesco, K. L., Agajanian, R., and Láng, Ildikó

Subjects
Orvostudományok, Klinikai orvostudományok
Abstract

LB

Published
2017

21. A uniform, quality controlled Surface Ocean CO2 Atlas (SOCAT)

Author

Pfeil, B., Olsen, A., Bakker, D. C. E., Hankin, S., Koyuk, H., Kozyr, A., Malczyk, J., Manke, A., Metzl, N., Sabine, C. L., Akl, J., Alin, S. R., Bellerby, R. G. J., Borges, A., Boutin, J., Brown, P. J., Cai, W.-J., Chavez, F. P., Chen, A., Cosca, C., Fassbender, A. J., Feely, R. A., González-Dávila, M., Goyet, C., Hardman-Mountford, N., Heinze, C., Hood, M., Hoppema, M., Hunt, C. W., Hydes, D., Ishii, M., Johannessen, T., Jones, S. D., Key, R. M., Körtzinger, A., Landschützer, P., Lauvset, S. K., Lefèvre, N., Lenton, A., Lourantou, A., Merlivat, L., Midorikawa, T., Mintrop, L., Miyazaki, C., Murata, A., Nakadate, A., Nakano, Y., Nakaoka, S., Nojiri, Y., Omar, A. M., Padin, X. A., Park, G.-H., Paterson, K., Perez, F. F., Pierrot, D., Poisson, A., Ríos, A. F., Santana-Casiano, J. M., Salisbury, J., Sarma, V. V. S. S., Schlitzer, R., Schneider, B., Schuster, U., Sieger, R., Skjelvan, I., Steinhoff, Tobias, Suzuki, T., Takahashi, T., Tedesco, K., Telszewski, M., Thomas, H., Tilbrook, B., Tjiputra, J., Vandemark, D., Veness, T., Wanninkhof, R., Watson, A. J., Weiss, R., Wong, C. S., Yoshikawa-Inoue, H., Pfeil, B., Olsen, A., Bakker, D. C. E., Hankin, S., Koyuk, H., Kozyr, A., Malczyk, J., Manke, A., Metzl, N., Sabine, C. L., Akl, J., Alin, S. R., Bellerby, R. G. J., Borges, A., Boutin, J., Brown, P. J., Cai, W.-J., Chavez, F. P., Chen, A., Cosca, C., Fassbender, A. J., Feely, R. A., González-Dávila, M., Goyet, C., Hardman-Mountford, N., Heinze, C., Hood, M., Hoppema, M., Hunt, C. W., Hydes, D., Ishii, M., Johannessen, T., Jones, S. D., Key, R. M., Körtzinger, A., Landschützer, P., Lauvset, S. K., Lefèvre, N., Lenton, A., Lourantou, A., Merlivat, L., Midorikawa, T., Mintrop, L., Miyazaki, C., Murata, A., Nakadate, A., Nakano, Y., Nakaoka, S., Nojiri, Y., Omar, A. M., Padin, X. A., Park, G.-H., Paterson, K., Perez, F. F., Pierrot, D., Poisson, A., Ríos, A. F., Santana-Casiano, J. M., Salisbury, J., Sarma, V. V. S. S., Schlitzer, R., Schneider, B., Schuster, U., Sieger, R., Skjelvan, I., Steinhoff, Tobias, Suzuki, T., Takahashi, T., Tedesco, K., Telszewski, M., Thomas, H., Tilbrook, B., Tjiputra, J., Vandemark, D., Veness, T., Wanninkhof, R., Watson, A. J., Weiss, R., Wong, C. S., and Yoshikawa-Inoue, H.

Abstract

A well documented, publicly available, global data set of surface ocean carbon dioxide (CO2) parameters has been called for by international groups for nearly two decades. The Surface Ocean CO2 Atlas (SOCAT) project was initiated by the international marine carbon science community in 2007 with the aim of providing a comprehensive, publicly available, regularly updated, global data set of marine surface CO2, which had been subject to quality control (QC). Many additional CO2 data, not yet made public via the Carbon Dioxide Information Analysis Center (CDIAC), were retrieved from data originators, public websites and other data centres. All data were put in a uniform format following a strict protocol. Quality control was carried out according to clearly defined criteria. Regional specialists performed the quality control, using state-of-the-art web-based tools, specially developed for accomplishing this global team effort. SOCAT version 1.5 was made public in September 2011 and holds 6.3 million quality controlled surface CO2 data points from the global oceans and coastal seas, spanning four decades (1968–2007). Three types of data products are available: individual cruise files, a merged complete data set and gridded products. With the rapid expansion of marine CO2 data collection and the importance of quantifying net global oceanic CO2 uptake and its changes, sustained data synthesis and data access are priorities

Published
2013

22. Surface Ocean CO2 Atlas (SOCAT) Gridded Data Products

Author

Sabine, C. L., Hankin, S., Koyuk, H., Bakker, D. C. E., Pfeil, B., Olsen, A., Metzl, N., Kozyr, A., Fassbender, A., Manke, A., Malczyk, J., Akl, J., Alin, S. R., Bellerby, R. G. J., Borges, A., Boutin, J., Brown, P. J., Cai, W. -j., Chavez, F. P., Chen, A., Cosca, C., Feely, R. A., Gonzalez-davila, M., Goyet, C., Hardman-mountford, N., Heinze, C., Hoppema, M., Hunt, C. W., Hydes, D., Ishii, M., Johannessen, T., Key, R. M., Koertzinger, A., Landschuetzer, P., Lauvset, S. K., Lefevre, N., Lenton, A., Lourantou, A., Merlivat, L., Midorikawa, T., Mintrop, L., Miyazaki, C., Murata, A., Nakadate, A., Nakano, Y., Nakaoka, S., Nojiri, Y., Omar, A. M., Padin, X. A., Park, G. -h., Paterson, K., Perez, F.f., Pierrot, D., Poisson, A., Rios, A. F., Salisbury, J., Santana-casiano, J. M., Sarma, V. V. S. S., Schlitzer, R., Schneider, B., Schuster, U., Sieger, R., Skjelvan, I., Steinhoff, T., Suzuki, T., Takahashi, T., Tedesco, K., Telszewski, M., Thomas, H., Tilbrook, B., Vandemark, D., Veness, T., Watson, A. J., Weiss, R., Wong, C. S., Yoshikawa-inoue, H., Sabine, C. L., Hankin, S., Koyuk, H., Bakker, D. C. E., Pfeil, B., Olsen, A., Metzl, N., Kozyr, A., Fassbender, A., Manke, A., Malczyk, J., Akl, J., Alin, S. R., Bellerby, R. G. J., Borges, A., Boutin, J., Brown, P. J., Cai, W. -j., Chavez, F. P., Chen, A., Cosca, C., Feely, R. A., Gonzalez-davila, M., Goyet, C., Hardman-mountford, N., Heinze, C., Hoppema, M., Hunt, C. W., Hydes, D., Ishii, M., Johannessen, T., Key, R. M., Koertzinger, A., Landschuetzer, P., Lauvset, S. K., Lefevre, N., Lenton, A., Lourantou, A., Merlivat, L., Midorikawa, T., Mintrop, L., Miyazaki, C., Murata, A., Nakadate, A., Nakano, Y., Nakaoka, S., Nojiri, Y., Omar, A. M., Padin, X. A., Park, G. -h., Paterson, K., Perez, F.f., Pierrot, D., Poisson, A., Rios, A. F., Salisbury, J., Santana-casiano, J. M., Sarma, V. V. S. S., Schlitzer, R., Schneider, B., Schuster, U., Sieger, R., Skjelvan, I., Steinhoff, T., Suzuki, T., Takahashi, T., Tedesco, K., Telszewski, M., Thomas, H., Tilbrook, B., Vandemark, D., Veness, T., Watson, A. J., Weiss, R., Wong, C. S., and Yoshikawa-inoue, H.

Abstract

A well documented, publicly available, global data set for surface ocean carbon dioxide (CO2) parameters has been called for by international groups for nearly two decades. The Surface Ocean CO2 Atlas (SOCAT) project was initiated by the international marine carbon science community in 2007 with the aim of providing a comprehensive, publicly available, regularly updated, global data set of marine surface CO2, which had been subject to quality control (QC). SOCAT version 1.5 was made public in September 2011 and holds 6.3 million quality controlled surface CO2 data from the global oceans and coastal seas, spanning four decades (1968–2007). The SOCAT gridded data is the second data product to come from the SOCAT project. Recognizing that some groups may have trouble working with millions of measurements, the SOCAT gridded product was generated to provide a robust regularly spaced fCO2 product with minimal spatial and temporal interpolation which should be easier to work with for many applications. Gridded SOCAT is rich with information that has not been fully explored yet, but also contains biases and limitations that the user needs to recognize and address.

Published
2013
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23. Surface Ocean CO2 Atlas (SOCAT) gridded data products

Author

Sabine, C.L., Hankin, S., Koyuk, H., Bakker, D.C.E., Pfeil, B., Olsen, A., Metzl, N., Kozyr, A., Fassbender, A., Manke, A., Malczyk, J., Akl, J., Alin, S.R., Bellerby, R.G.J., Borges, A., Boutin, J., Brown, P.J., Cai, W.-J., Chavez, F.P., Chen, A., Cosca, C., Feely, R.A., González-Dávila, M., Goyet, C., Hardman-Mountford, N., Heinze, C., Hoppema, Mario, Hunt, C.W., Hydes, D., Ishii, M., Johannessen, T., Key, R.M., Körtzinger, A., Landschützer, P., Lauvset, S.K., Lefèvre, N., Lenton, A., Lourantou, A., Merlivat, L., Midorikawa, T., Mintrop, L., Miyazaki, C., Murata, A., Nakadate, A., Nakano, Y., Nakaoka, S., Nojiri, Y., Omar, A.M., Padin, X.A., Park, G.-H., Paterson, K., Perez, F.F., Pierrot, D., Poisson, A., Ríos, A.F., Salisbury, J., Santana-Casiano, J.M., Sarma, V.V.S.S., Schlitzer, Reiner, Schneider, B., Schuster, U., Sieger, Rainer, Skjelvan, I., Steinhoff, T., Suzuki, T., Takahashi, T., Tedesco, K., Telszewski, M., Thomas, H., Tilbrook, B., Vandemark, D., Veness, T., Watson, A.J., Weiss, R., Wong, C.S., Yoshikawa-Inoue, H., Sabine, C.L., Hankin, S., Koyuk, H., Bakker, D.C.E., Pfeil, B., Olsen, A., Metzl, N., Kozyr, A., Fassbender, A., Manke, A., Malczyk, J., Akl, J., Alin, S.R., Bellerby, R.G.J., Borges, A., Boutin, J., Brown, P.J., Cai, W.-J., Chavez, F.P., Chen, A., Cosca, C., Feely, R.A., González-Dávila, M., Goyet, C., Hardman-Mountford, N., Heinze, C., Hoppema, Mario, Hunt, C.W., Hydes, D., Ishii, M., Johannessen, T., Key, R.M., Körtzinger, A., Landschützer, P., Lauvset, S.K., Lefèvre, N., Lenton, A., Lourantou, A., Merlivat, L., Midorikawa, T., Mintrop, L., Miyazaki, C., Murata, A., Nakadate, A., Nakano, Y., Nakaoka, S., Nojiri, Y., Omar, A.M., Padin, X.A., Park, G.-H., Paterson, K., Perez, F.F., Pierrot, D., Poisson, A., Ríos, A.F., Salisbury, J., Santana-Casiano, J.M., Sarma, V.V.S.S., Schlitzer, Reiner, Schneider, B., Schuster, U., Sieger, Rainer, Skjelvan, I., Steinhoff, T., Suzuki, T., Takahashi, T., Tedesco, K., Telszewski, M., Thomas, H., Tilbrook, B., Vandemark, D., Veness, T., Watson, A.J., Weiss, R., Wong, C.S., and Yoshikawa-Inoue, H.

Abstract

As a response to public demand for a well documented, quality controlled, publically available, global surface ocean carbon dioxide (CO2) data set, the international marine carbon science community developed the Surface Ocean CO2 Atlas (SOCAT). The first SOCAT product is a collection of 6.3 million quality controlled surface CO2 data from the global oceans and coastal seas, spanning four decades (1968–2007). The SOCAT gridded data presented here is the second data product to come from the SOCAT project. Recognizing that some groups may have trouble working with millions of measurements, the SOCAT gridded product was generated to provide a robust, regularly spaced CO2 fugacity (fCO2) product with minimal spatial and temporal interpolation, which should be easier to work with for many applications. Gridded SOCAT is rich with information that has not been fully explored yet (e.g., regional differences in the seasonal cycles), but also contains biases and limitations that the user needs to recognize and address (e.g., local influences on values in some coastal regions).

Published
2013

24. A uniform, quality controlled Surface Ocean CO2 Atlas (SOCAT)

Author

Pfeil, B., Olsen, A., Bakker, D. C. E., Hankin, S., Koyuk, H., Kozyr, A., Malczyk, J., Manke, A., Metzl, N., Sabine, C. L., Akl, J., Alin, S. R., Bellerby, R. G. J., Borges, A., Boutin, J., Brown, P. J., Cai, W.-J., Chavez, F. P., Chen, A., Cosca, C., Fassbender, A. J., Feely, R. A., González-Dávila, M., Goyet, C., Hardman-Mountford, N., Heinze, C., Hood, M., Hoppema, M., Hunt, C. W., Hydes, D., Ishii, M., Johannessen, T., Jones, S. D., Key, R. M., Körtzinger, A., Landschützer, P., Lauvset, S. K., Lefèvre, N., Lenton, A., Lourantou, A., Merlivat, L., Midorikawa, T., Mintrop, L., Miyazaki, C., Murata, A., Nakadate, A., Nakano, Y., Nakaoka, S., Nojiri, Y., Omar, A. M., Padin, X. A., Park, G.-H., Paterson, K., Perez, F. F., Pierrot, D., Poisson, A., Ríos, A. F., Santana-Casiano, J. M., Salisbury, J., Sarma, V. V. S. S., Schlitzer, R., Schneider, B., Schuster, U., Sieger, R., Skjelvan, I., Steinhoff, T., Suzuki, T., Takahashi, T., Tedesco, K., Telszewski, M., Thomas, H., Tilbrook, B., Tjiputra, J., Vandemark, D., Veness, T., Wanninkhof, R., Watson, A. J., Weiss, R., Wong, C. S., Yoshikawa-Inoue, H., Pfeil, B., Olsen, A., Bakker, D. C. E., Hankin, S., Koyuk, H., Kozyr, A., Malczyk, J., Manke, A., Metzl, N., Sabine, C. L., Akl, J., Alin, S. R., Bellerby, R. G. J., Borges, A., Boutin, J., Brown, P. J., Cai, W.-J., Chavez, F. P., Chen, A., Cosca, C., Fassbender, A. J., Feely, R. A., González-Dávila, M., Goyet, C., Hardman-Mountford, N., Heinze, C., Hood, M., Hoppema, M., Hunt, C. W., Hydes, D., Ishii, M., Johannessen, T., Jones, S. D., Key, R. M., Körtzinger, A., Landschützer, P., Lauvset, S. K., Lefèvre, N., Lenton, A., Lourantou, A., Merlivat, L., Midorikawa, T., Mintrop, L., Miyazaki, C., Murata, A., Nakadate, A., Nakano, Y., Nakaoka, S., Nojiri, Y., Omar, A. M., Padin, X. A., Park, G.-H., Paterson, K., Perez, F. F., Pierrot, D., Poisson, A., Ríos, A. F., Santana-Casiano, J. M., Salisbury, J., Sarma, V. V. S. S., Schlitzer, R., Schneider, B., Schuster, U., Sieger, R., Skjelvan, I., Steinhoff, T., Suzuki, T., Takahashi, T., Tedesco, K., Telszewski, M., Thomas, H., Tilbrook, B., Tjiputra, J., Vandemark, D., Veness, T., Wanninkhof, R., Watson, A. J., Weiss, R., Wong, C. S., and Yoshikawa-Inoue, H.

Published
2012

25. Surface Ocean CO2 Atlas (SOCAT) gridded data products

Author

Sabine, C. L., Hankin, S., Koyuk, H., Bakker, D. C. E., Pfeil, B., Olsen, A., Metzl, N., Kozyr, A., Fassbender, A., Manke, A., Malczyk, J., Akl, J., Alin, S. R., Bellerby, R. G. J., Borges, A., Boutin, J., Brown, P. J., Cai, W.-J., Chavez, F. P., Chen, A., Cosca, C., Feely, R. A., González-Dávila, M., Goyet, C., Hardman-Mountford, N., Heinze, C., Hoppema, M., Hunt, C. W., Hydes, D., Ishii, M., Johannessen, T., Key, R. M., Körtzinger, A., Landschützer, P., Lauvset, S. K., Lefèvre, N., Lenton, A., Lourantou, A., Merlivat, L., Midorikawa, T., Mintrop, L., Miyazaki, C., Murata, A., Nakadate, A., Nakano, Y., Nakaoka, S., Nojiri, Y., Omar, A. M., Padin, X. A., Park, G.-H., Paterson, K., Perez, F. F., Pierrot, D., Poisson, A., Ríos, A. F., Salisbury, J., Santana-Casiano, J. M., Sarma, V. V. S. S., Schlitzer, R., Schneider, B., Schuster, U., Sieger, R., Skjelvan, I., Steinhoff, T., Suzuki, T., Takahashi, T., Tedesco, K., Telszewski, M., Thomas, H., Tilbrook, B., Vandemark, D., Veness, T., Watson, A. J., Weiss, R., Wong, C. S., Yoshikawa-Inoue, H., Sabine, C. L., Hankin, S., Koyuk, H., Bakker, D. C. E., Pfeil, B., Olsen, A., Metzl, N., Kozyr, A., Fassbender, A., Manke, A., Malczyk, J., Akl, J., Alin, S. R., Bellerby, R. G. J., Borges, A., Boutin, J., Brown, P. J., Cai, W.-J., Chavez, F. P., Chen, A., Cosca, C., Feely, R. A., González-Dávila, M., Goyet, C., Hardman-Mountford, N., Heinze, C., Hoppema, M., Hunt, C. W., Hydes, D., Ishii, M., Johannessen, T., Key, R. M., Körtzinger, A., Landschützer, P., Lauvset, S. K., Lefèvre, N., Lenton, A., Lourantou, A., Merlivat, L., Midorikawa, T., Mintrop, L., Miyazaki, C., Murata, A., Nakadate, A., Nakano, Y., Nakaoka, S., Nojiri, Y., Omar, A. M., Padin, X. A., Park, G.-H., Paterson, K., Perez, F. F., Pierrot, D., Poisson, A., Ríos, A. F., Salisbury, J., Santana-Casiano, J. M., Sarma, V. V. S. S., Schlitzer, R., Schneider, B., Schuster, U., Sieger, R., Skjelvan, I., Steinhoff, T., Suzuki, T., Takahashi, T., Tedesco, K., Telszewski, M., Thomas, H., Tilbrook, B., Vandemark, D., Veness, T., Watson, A. J., Weiss, R., Wong, C. S., and Yoshikawa-Inoue, H.

Published
2012

26. SOCAT Data treatment and adjustments

Author

Pfeil, B., Olsen, A., Bakker, D. C. E., Sabine, C., Metzl, N., Kozyr, A., Borges, A., Schuster, U., Telszewski, M., Chen, A., Tilbrook, B., Sarma, V. V. S. S., Feely, R., Wanninkhof, R., Hankin, S., Koyuk, H., Malczyk, J., Tedesco, K., Cosca, C., Miyazaki, C., Hunt, C., Pierrot, D., Park, G. H., Skjelvan, I., Paterson, K., Santana-Casiano, M., Hood, M., Hoppema, Mario, Watson, A., Lourantou, A., Padin, A., Lefevre, N., Hardman-Mountford, N., Omar, A., Nakaoka, S., Alin, S., Steinhoff, T., Suzuki, T., Johannessen, T., Nakana, Y., Nojiri, Y., Pfeil, B., Olsen, A., Bakker, D. C. E., Sabine, C., Metzl, N., Kozyr, A., Borges, A., Schuster, U., Telszewski, M., Chen, A., Tilbrook, B., Sarma, V. V. S. S., Feely, R., Wanninkhof, R., Hankin, S., Koyuk, H., Malczyk, J., Tedesco, K., Cosca, C., Miyazaki, C., Hunt, C., Pierrot, D., Park, G. H., Skjelvan, I., Paterson, K., Santana-Casiano, M., Hood, M., Hoppema, Mario, Watson, A., Lourantou, A., Padin, A., Lefevre, N., Hardman-Mountford, N., Omar, A., Nakaoka, S., Alin, S., Steinhoff, T., Suzuki, T., Johannessen, T., Nakana, Y., and Nojiri, Y.

Published
2011

27. Surface Ocean CO&lt;sub&gt;2&lt;/sub&gt; Atlas (SOCAT) gridded data products

Author

Sabine, C. L., primary, Hankin, S., additional, Koyuk, H., additional, Bakker, D. C. E., additional, Pfeil, B., additional, Olsen, A., additional, Metzl, N., additional, Kozyr, A., additional, Fassbender, A., additional, Manke, A., additional, Malczyk, J., additional, Akl, J., additional, Alin, S. R., additional, Bellerby, R. G. J., additional, Borges, A., additional, Boutin, J., additional, Brown, P. J., additional, Cai, W.-J., additional, Chavez, F. P., additional, Chen, A., additional, Cosca, C., additional, Feely, R. A., additional, González-Dávila, M., additional, Goyet, C., additional, Hardman-Mountford, N., additional, Heinze, C., additional, Hoppema, M., additional, Hunt, C. W., additional, Hydes, D., additional, Ishii, M., additional, Johannessen, T., additional, Key, R. M., additional, Körtzinger, A., additional, Landschützer, P., additional, Lauvset, S. K., additional, Lefèvre, N., additional, Lenton, A., additional, Lourantou, A., additional, Merlivat, L., additional, Midorikawa, T., additional, Mintrop, L., additional, Miyazaki, C., additional, Murata, A., additional, Nakadate, A., additional, Nakano, Y., additional, Nakaoka, S., additional, Nojiri, Y., additional, Omar, A. M., additional, Padin, X. A., additional, Park, G.-H., additional, Paterson, K., additional, Perez, F. F., additional, Pierrot, D., additional, Poisson, A., additional, Ríos, A. F., additional, Salisbury, J., additional, Santana-Casiano, J. M., additional, Sarma, V. V. S. S., additional, Schlitzer, R., additional, Schneider, B., additional, Schuster, U., additional, Sieger, R., additional, Skjelvan, I., additional, Steinhoff, T., additional, Suzuki, T., additional, Takahashi, T., additional, Tedesco, K., additional, Telszewski, M., additional, Thomas, H., additional, Tilbrook, B., additional, Vandemark, D., additional, Veness, T., additional, Watson, A. J., additional, Weiss, R., additional, Wong, C. S., additional, and Yoshikawa-Inoue, H., additional

Published
2013
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28. A uniform, quality controlled Surface Ocean CO&lt;sub&gt;2&lt;/sub&gt; Atlas (SOCAT)

Author

Pfeil, B., primary, Olsen, A., additional, Bakker, D. C. E., additional, Hankin, S., additional, Koyuk, H., additional, Kozyr, A., additional, Malczyk, J., additional, Manke, A., additional, Metzl, N., additional, Sabine, C. L., additional, Akl, J., additional, Alin, S. R., additional, Bates, N., additional, Bellerby, R. G. J., additional, Borges, A., additional, Boutin, J., additional, Brown, P. J., additional, Cai, W.-J., additional, Chavez, F. P., additional, Chen, A., additional, Cosca, C., additional, Fassbender, A. J., additional, Feely, R. A., additional, González-Dávila, M., additional, Goyet, C., additional, Hales, B., additional, Hardman-Mountford, N., additional, Heinze, C., additional, Hood, M., additional, Hoppema, M., additional, Hunt, C. W., additional, Hydes, D., additional, Ishii, M., additional, Johannessen, T., additional, Jones, S. D., additional, Key, R. M., additional, Körtzinger, A., additional, Landschützer, P., additional, Lauvset, S. K., additional, Lefèvre, N., additional, Lenton, A., additional, Lourantou, A., additional, Merlivat, L., additional, Midorikawa, T., additional, Mintrop, L., additional, Miyazaki, C., additional, Murata, A., additional, Nakadate, A., additional, Nakano, Y., additional, Nakaoka, S., additional, Nojiri, Y., additional, Omar, A. M., additional, Padin, X. A., additional, Park, G.-H., additional, Paterson, K., additional, Perez, F. F., additional, Pierrot, D., additional, Poisson, A., additional, Ríos, A. F., additional, Santana-Casiano, J. M., additional, Salisbury, J., additional, Sarma, V. V. S. S., additional, Schlitzer, R., additional, Schneider, B., additional, Schuster, U., additional, Sieger, R., additional, Skjelvan, I., additional, Steinhoff, T., additional, Suzuki, T., additional, Takahashi, T., additional, Tedesco, K., additional, Telszewski, M., additional, Thomas, H., additional, Tilbrook, B., additional, Tjiputra, J., additional, Vandemark, D., additional, Veness, T., additional, Wanninkhof, R., additional, Watson, A. J., additional, Weiss, R., additional, Wong, C. S., additional, and Yoshikawa-Inoue, H., additional

Published
2013
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29. A uniform, quality controlled Surface Ocean CO&lt;sub&gt;2&lt;/sub&gt; Atlas (SOCAT)

Author

Pfeil, B., primary, Olsen, A., additional, Bakker, D. C. E., additional, Hankin, S., additional, Koyuk, H., additional, Kozyr, A., additional, Malczyk, J., additional, Manke, A., additional, Metzl, N., additional, Sabine, C. L., additional, Akl, J., additional, Alin, S. R., additional, Bellerby, R. G. J., additional, Borges, A., additional, Boutin, J., additional, Brown, P. J., additional, Cai, W.-J., additional, Chavez, F. P., additional, Chen, A., additional, Cosca, C., additional, Fassbender, A. J., additional, Feely, R. A., additional, González-Dávila, M., additional, Goyet, C., additional, Hardman-Mountford, N., additional, Heinze, C., additional, Hood, M., additional, Hoppema, M., additional, Hunt, C. W., additional, Hydes, D., additional, Ishii, M., additional, Johannessen, T., additional, Jones, S. D., additional, Key, R. M., additional, Körtzinger, A., additional, Landschützer, P., additional, Lauvset, S. K., additional, Lefèvre, N., additional, Lenton, A., additional, Lourantou, A., additional, Merlivat, L., additional, Midorikawa, T., additional, Mintrop, L., additional, Miyazaki, C., additional, Murata, A., additional, Nakadate, A., additional, Nakano, Y., additional, Nakaoka, S., additional, Nojiri, Y., additional, Omar, A. M., additional, Padin, X. A., additional, Park, G.-H., additional, Paterson, K., additional, Perez, F. F., additional, Pierrot, D., additional, Poisson, A., additional, Ríos, A. F., additional, Santana-Casiano, J. M., additional, Salisbury, J., additional, Sarma, V. V. S. S., additional, Schlitzer, R., additional, Schneider, B., additional, Schuster, U., additional, Sieger, R., additional, Skjelvan, I., additional, Steinhoff, T., additional, Suzuki, T., additional, Takahashi, T., additional, Tedesco, K., additional, Telszewski, M., additional, Thomas, H., additional, Tilbrook, B., additional, Tjiputra, J., additional, Vandemark, D., additional, Veness, T., additional, Wanninkhof, R., additional, Watson, A. J., additional, Weiss, R., additional, Wong, C. S., additional, and Yoshikawa-Inoue, H., additional

Published
2012
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30. Surface Ocean CO&lt;sub&gt;2&lt;/sub&gt; Atlas (SOCAT) gridded data products

Author

Sabine, C. L., primary, Hankin, S., additional, Koyuk, H., additional, Bakker, D. C. E., additional, Pfeil, B., additional, Olsen, A., additional, Metzl, N., additional, Kozyr, A., additional, Fassbender, A., additional, Manke, A., additional, Malczyk, J., additional, Akl, J., additional, Alin, S. R., additional, Bellerby, R. G. J., additional, Borges, A., additional, Boutin, J., additional, Brown, P. J., additional, Cai, W.-J., additional, Chavez, F. P., additional, Chen, A., additional, Cosca, C., additional, Feely, R. A., additional, González-Dávila, M., additional, Goyet, C., additional, Hardman-Mountford, N., additional, Heinze, C., additional, Hoppema, M., additional, Hunt, C. W., additional, Hydes, D., additional, Ishii, M., additional, Johannessen, T., additional, Key, R. M., additional, Körtzinger, A., additional, Landschützer, P., additional, Lauvset, S. K., additional, Lefèvre, N., additional, Lenton, A., additional, Lourantou, A., additional, Merlivat, L., additional, Midorikawa, T., additional, Mintrop, L., additional, Miyazaki, C., additional, Murata, A., additional, Nakadate, A., additional, Nakano, Y., additional, Nakaoka, S., additional, Nojiri, Y., additional, Omar, A. M., additional, Padin, X. A., additional, Park, G.-H., additional, Paterson, K., additional, Perez, F. F., additional, Pierrot, D., additional, Poisson, A., additional, Ríos, A. F., additional, Salisbury, J., additional, Santana-Casiano, J. M., additional, Sarma, V. V. S. S., additional, Schlitzer, R., additional, Schneider, B., additional, Schuster, U., additional, Sieger, R., additional, Skjelvan, I., additional, Steinhoff, T., additional, Suzuki, T., additional, Takahashi, T., additional, Tedesco, K., additional, Telszewski, M., additional, Thomas, H., additional, Tilbrook, B., additional, Vandemark, D., additional, Veness, T., additional, Watson, A. J., additional, Weiss, R., additional, Wong, C. S., additional, and Yoshikawa-Inoue, H., additional

Published
2012
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33. Preliminary safety and activity results of trabectedin in a phase II trial dedicated to triple-negative (ER-, PR-, HER2-), HER2+++, or BRCA1/2 germ-line-mutated metastatic breast cancer (MBC) patients (pts)

Author

Delaloge, S., primary, Tedesco, K. L., additional, Blum, J., additional, Gonçalves, A., additional, Lubinski, J., additional, Efrat, N., additional, Osborne, C., additional, Lebedinsky, C., additional, Tercero, J. C., additional, and Holmes, F. A., additional

Published
2009
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38. The NICU Cuddler Curriculum: A Service-Learning Curriculum for Preclinical Medical Students in the Neonatal Intensive Care Unit.

Author

Insley E, Tedesco K, Litman EA, Mangalapally N, Gicewicz C, and Monaco-Brown ML

Subjects
Curriculum, Humans, Infant, Infant, Newborn, Intensive Care Units, Neonatal, Students, Medical
Abstract

Introduction: The neonatal intensive care unit (NICU) is often seen as off-limits by preclinical medical students. The NICU cuddler curriculum is a service-learning curriculum that invited preclinical medical students into the NICU to engage with and learn from one of the hospital's most vulnerable populations: neonates. The purpose of this preclinical experience was to provide students with exposure to the NICU and an opportunity to engage with babies, families, and the NICU staff, in order to improve students' clinical and communication skills., Methods: First- and second- year medical students applied and were selected for participation. Participants cuddled neonates in the NICU for at least 10 hours, attended didactic sessions relevant to neonatal care, and debriefed with an attending each semester. The curriculum was evaluated via qualitative analysis and postparticipation surveys., Results: To date, a total of 73 students have participated in the NICU cuddler curriculum. Qualitative analysis revealed students felt included in patient care, empowered in their understanding of the social determinants of health, and useful in their role. A postsurvey of clinical medical students following participation revealed the sustained impact of this program., Discussion: This service-learning curriculum for preclinical medical students has the potential to enhance student understanding of the social determinants of health, increase exposure to the NICU, and promote interprofessional collaboration, ultimately increasing preparedness of students for their clinical years., (© 2021 Insley et al.)

Published
2021
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39. Phase II Study of Eribulin Mesylate Administered Biweekly in Patients With Human Epidermal Growth Factor Receptor-2-negative Metastatic Breast Cancer.

Author

Smith J 2nd, Irwin A, Jensen L, Tedesco K, Misir S, Zhu W, Almonte A, He Y, Xie R, Olivo M, and O'Shaughnessy J

Subjects
Adult, Aged, Aged, 80 and over, Antineoplastic Agents adverse effects, Breast Neoplasms mortality, Breast Neoplasms pathology, Drug Administration Schedule, Female, Furans adverse effects, Granulocyte Colony-Stimulating Factor administration & dosage, Humans, Injections, Intravenous, Ketones adverse effects, Middle Aged, Neutropenia chemically induced, Neutropenia diagnosis, Neutropenia prevention & control, Prognosis, Progression-Free Survival, Receptor, ErbB-2 analysis, Severity of Illness Index, Antineoplastic Agents administration & dosage, Breast Neoplasms drug therapy, Furans administration & dosage, Ketones administration & dosage, Neutropenia epidemiology
Abstract

Background: Patients with human epidermal growth factor receptor-2-negative metastatic breast cancer (MBC), whose disease progressed on prior chemotherapy, have a poor prognosis. Eribulin, a microtubule dynamics inhibitor, extends overall survival in previously treated MBC. The most common adverse event associated with eribulin is neutropenia, which may result in dose interruptions or reductions. A modified biweekly dosing schedule of eribulin was assessed for efficacy as well as improvements in hematologic toxicity., Patients and Methods: In this open-label, single-arm, multicenter, phase II study, previously treated (2-5 chemotherapy regimens for metastatic disease) patients with human epidermal growth factor receptor-2-negative MBC received intravenous eribulin 1.4 mg/m 2 over 2 to 5 minutes on days 1 and 15 of each 28-day cycle. The primary study endpoints were objective response rate (ORR; complete response [CR] + partial responses [PR]) and disease control rate (DCR; CR + PR + stable disease [SD])., Results: Among 58 treated patients, the ORR was 12% (95% confidence interval [CI], 5%-24%), DCR (CR, n = 1; PR, n = 6; SD, n = 30) was 65%, and the median progression-free survival was 3.6 months (95% CI, 2.9-4.1 months). Grade 3 or 4 neutropenia was 31%; 50% of all patients, and 78% of patients with neutropenia (all grades), received hematopoietic growth-factor support., Conclusion: The efficacy and safety results obtained with a biweekly eribulin schedule in this phase II trial appear similar to those associated with the approved eribulin schedule (1.4 mg/m 2 on days 1 and 8 of a 21-day cycle) reported in the EMBRACE study., (Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.)

Published
2020
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40. Increased cochlear fluid-attenuated inversion recovery signal in patients with vestibular schwannoma.

Author

Bhadelia RA, Tedesco KL, Hwang S, Erbay SH, Lee PH, Shao W, and Heilman C

Subjects
Adult, Aged, Aged, 80 and over, Female, Humans, Image Processing, Computer-Assisted, Male, Middle Aged, Proteins analysis, Cochlea pathology, Magnetic Resonance Imaging, Neuroma, Acoustic diagnosis, Perilymph chemistry
Abstract

Background and Purpose: Elevated protein levels have been reported in perilymph of patients with vestibular schwannoma. Fluid-attenuated inversion recovery (FLAIR) imaging is sensitive to high protein contents in fluids. The purpose of this study was to investigate if in patients with unilateral vestibular schwannoma, cochlear FLAIR signal intensity on the affected side is increased compared with the unaffected side and control subjects., Materials and Methods: Fifteen patients with unilateral vestibular schwannoma and 25 age-matched control subjects (without a history of hearing loss) were retrospectively evaluated. All patients and controls had routine 5-mm FLAIR and T1- and T2-weighted imaging of the brain. The signal intensity of both cochleae was evaluated by placing a small region of interest on FLAIR images. The signal intensity of the brain stem was also determined by placing a second region of interest. A ratio of cochlear signal intensity to brain stem signal intensity (CIBI ratio) was determined. A t test was used to compare the CIBI ratios., Results: In patients, the mean CIBI ratio of the affected side was 0.89 +/- 0.18, and that of the unaffected side was 0.57 +/- 0.12. In control subjects, it was 0.51 +/- 0.07. The CIBI ratio of the affected side was significantly higher compared with the unaffected side (P < .001) and compared with control subjects (P < .001)., Conclusion: Patients with vestibular schwannoma have increased cochlear FLAIR signal intensity on the affected side compared with the unaffected side and healthy subjects.

Published
2008
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