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2. Impact of biological sex on heart transplant patients admitted to cardiac rehabilitation: A 10-year retrospective cohort study

Author

Tedeschi, Andrea, Cusmano, Ignazio, Di Salvo, Francesca, Oreni, Letizia, Toccafondi, Anastasia, Tavanelli, Monica, Grati, Paola, Mapelli, Luca, Arrondini, Luisa, Cannadoro, Gianmarco, Gonella, Matteo, Barcella, Chiara, Stilo, Leone, Verde, Alessandro, Masciocco, Gabriella, Ruzzenenti, Giacomo, Biolcati, Marco, Garascia, Andrea, and Morici, Nuccia

Published
2024
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6. Pheochromocytoma-induced cardiogenic shock: A multicentre analysis of clinical profiles, management and outcomes

Author

De Angelis, Elena, Bochaton, Thomas, Ammirati, Enrico, Tedeschi, Andrea, Polito, Maria Vincenza, Pieroni, Maurizio, Merlo, Marco, Gentile, Piero, Van De Heyning, Caroline M., Bekelaar, Thalia, Cipriani, Alberto, Camilli, Massimiliano, Sanna, Tommaso, Marra, Martina Perazzolo, Cabassi, Aderville, Piepoli, Massimo F., Sinagra, Gianfranco, Mewton, Nathan, Bonnefoy-Cudraz, Eric, Ravera, Amelia, and Hayek, Ahmad

Published
2023
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7. Glucagon-like Peptide 1 Receptor Agonists in Cardio-Oncology: Pathophysiology of Cardiometabolic Outcomes in Cancer Patients.

Author

Quagliariello, Vincenzo, Canale, Maria Laura, Bisceglia, Irma, Iovine, Martina, Giordano, Vienna, Giacobbe, Ilaria, Scherillo, Marino, Gabrielli, Domenico, Maurea, Carlo, Barbato, Matteo, Inno, Alessandro, Berretta, Massimiliano, Tedeschi, Andrea, Oliva, Stefano, Greco, Alessandra, and Maurea, Nicola

Subjects
GLUCAGON-like peptide 1, TYPE 2 diabetes, PEPTIDE receptors, HEART failure, CANCER prognosis
Abstract

Cancer patients, especially long cancer survivors, are exposed to several cardio-metabolic diseases, including diabetes, heart failure, and atherosclerosis, which increase their risk of cardiovascular mortality. Therapy with glucagon-like peptide 1 (GLP1) receptor agonists demonstrated several beneficial cardiovascular effects, including atherosclerosis and heart failure prevention. Cardiovascular outcome trials (CVOTs) suggest that GLP-1 RA could exert cardiorenal benefits and systemic anti-inflammatory effects in patients with type-2 diabetes through the activation of cAMP and PI3K/AkT pathways and the inhibition of NLRP-3 and MyD88. In this narrative review, we highlight the biochemical properties of GLP-1 RA through a deep analysis of the clinical and preclinical evidence of the primary prevention of cardiomyopathies. The overall picture of this review encourages the study of GLP-1 RA in cancer patients with type-2 diabetes, as a potential primary prevention strategy against heart failure and atherosclerosis. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Epidemiology and clinical correlates of hidradenitis suppurativa in primary care in Italy.

Author

Lapi, Francesco, Marconi, Ettore, Casoli, Lucia, Tedeschi, Andrea, Giomi, Barbara, and Cricelli, Claudio

Subjects
DECISION support systems, CLINICAL epidemiology, PRIMARY care, PRIMARY health care, GENERAL practitioners
Abstract

Background Hidradenitis suppurativa (HS) is a persistent skin disorder that is characterized by painful lesions or pus-filled lumps, mostly occurring in areas where the skin flexes. It is a disfiguring condition that significantly reduces the quality of life of those affected. Developing new, effective treatments for HS is crucial, but it is important that it be recognized and diagnosed early, especially in primary care settings. Objectives To assess the epidemiology and clinical correlates of HS in a primary care setting. The study utilized the Italian Health Search Database (HSD). A case-control design was adopted to investigate the clinical correlates of HS. Cases were classified as either "definite" or "probable" using an operational algorithm. Up to 10 controls were matched to each case based on factors such as calendar period, age, sex, and duration of follow-up. Results Cumulative prevalence of HS increased from 0.06% in 2002 to 0.46% in 2021. When only "definite" cases were considered, the prevalence was almost 10 times lower (0%–0.02%). Several clinical correlates were found to be positively associated with HS, including obesity, dyslipidemia, hypertension, autoimmune/inflammatory diseases, and depression. Conclusions This study found that correct diagnoses of HS were made, as demonstrated by the expected relationship with clinical correlates. These associations were consistent when probable cases were included in the analysis. This evidence could serve as a foundation for proposing a decision support system for general practitioners to help identify HS in individuals with certain coexisting conditions. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Robust Axonal Regeneration Occurs in the Injured CAST/Ei Mouse CNS.

Author

Omura, Takao, Omura, Kumiko, Tedeschi, Andrea, Riva, Priscilla, Painter, Michio W, Rojas, Leticia, Martin, Joshua, Lisi, Véronique, Huebner, Eric A, Latremoliere, Alban, Yin, Yuqin, Barrett, Lee B, Singh, Bhagat, Lee, Stella, Crisman, Tom, Gao, Fuying, Li, Songlin, Kapur, Kush, Geschwind, Daniel H, Kosik, Kenneth S, Coppola, Giovanni, He, Zhigang, Carmichael, S Thomas, Benowitz, Larry I, Costigan, Michael, and Woolf, Clifford J

Subjects
Neurosciences, Cognitive Sciences, Neurology & Neurosurgery, Psychology
Published
2016

16. Gabapentinoid treatment promotes corticospinal plasticity and regeneration following murine spinal cord injury

Author

Sun, Wenjing, Larson, Molly J.E., Kiyoshi, Conrad M., Annett, Alexander J., Stalker, William A., Peng, Juan, and Tedeschi, Andrea

Subjects
Cell Signaling Technologies, Calcium channels, Gabapentin, Spinal cord injuries, Biotechnology industries, Neurons, Disabilities, Health care industry
Abstract

Axon regeneration failure causes neurological deficits and long-term disability after spinal cord injury (SCI). Here, we found that the [alpha]2[delta]2 subunit of voltage-gated calcium channels negatively regulates axon growth and regeneration of corticospinal neurons, the cells that originate the corticospinal tract. Increased [alpha]2[delta]2 expression in corticospinal neurons contributed to loss of corticospinal regrowth ability during postnatal development and after SCI. In contrast, [alpha]2[delta]2 pharmacological blockade through gabapentin administration promoted corticospinal structural plasticity and regeneration in adulthood. Using an optogenetic strategy combined with in vivo electrophysiological recording, we demonstrated that regenerating corticospinal axons functionally integrate into spinal circuits. Mice administered gabapentin recovered upper extremity function after cervical SCI. Importantly, such recovery relies on reorganization of the corticospinal pathway, as chemogenetic silencing of injured corticospinal neurons transiently abrogated recovery. Thus, targeting [alpha]2[delta]2 with a clinically relevant treatment strategy aids repair of motor circuits after SCI., Introduction Injuries to the adult spinal cord disrupt communication between the brain and the spinal cord, causing neurological deficits and long-term disability. In about half of individuals with spinal cord [...]

Published
2020
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17. Robust Axonal Regeneration Occurs in the Injured CAST/Ei Mouse CNS.

Author

Omura, Takao, Omura, Kumiko, Tedeschi, Andrea, Riva, Priscilla, Painter, Michio W, Rojas, Leticia, Martin, Joshua, Lisi, Véronique, Huebner, Eric A, Latremoliere, Alban, Yin, Yuqin, Barrett, Lee B, Singh, Bhagat, Lee, Stella, Crisman, Tom, Gao, Fuying, Li, Songlin, Kapur, Kush, Geschwind, Daniel H, Kosik, Kenneth S, Coppola, Giovanni, He, Zhigang, Carmichael, S Thomas, Benowitz, Larry I, Costigan, Michael, and Woolf, Clifford J

Subjects
Ganglia, Spinal, Axons, Animals, Mice, Inbred C3H, Mice, Inbred C57BL, Mice, Inbred DBA, Mice, Inbred NOD, Mice, Spinal Cord Injuries, Sciatic Neuropathy, Nerve Regeneration, Mice, 129 Strain, Ganglia, Spinal, Inbred C3H, Inbred C57BL, Inbred DBA, Inbred NOD, Strain, Spinal Cord Injury, Neurosciences, Injury - Trauma -, Genetics, Neurodegenerative, Regenerative Medicine, Brain Disorders, Stem Cell Research - Nonembryonic - Non-Human, Stem Cell Research, Injury (total) Accidents/Adverse Effects, 1.1 Normal biological development and functioning, Neurological, Neurology & Neurosurgery, Cognitive Sciences, Psychology
Abstract

Axon regeneration in the CNS requires reactivating injured neurons' intrinsic growth state and enabling growth in an inhibitory environment. Using an inbred mouse neuronal phenotypic screen, we find that CAST/Ei mouse adult dorsal root ganglion neurons extend axons more on CNS myelin than the other eight strains tested, especially when pre-injured. Injury-primed CAST/Ei neurons also regenerate markedly in the spinal cord and optic nerve more than those from C57BL/6 mice and show greater sprouting following ischemic stroke. Heritability estimates indicate that extended growth in CAST/Ei neurons on myelin is genetically determined, and two whole-genome expression screens yield the Activin transcript Inhba as most correlated with this ability. Inhibition of Activin signaling in CAST/Ei mice diminishes their CNS regenerative capacity, whereas its activation in C57BL/6 animals boosts regeneration. This screen demonstrates that mammalian CNS regeneration can occur and reveals a molecular pathway that contributes to this ability.

Published
2015

20. PTEN deletion enhances the regenerative ability of adult corticospinal neurons

Author

Liu, Kai, Lu, Yi, Lee, Jae K, Samara, Ramsey, Willenberg, Rafer, Sears-Kraxberger, Ilse, Tedeschi, Andrea, Park, Kevin Kyungsuk, Jin, Duo, Cai, Bin, Xu, Bengang, Connolly, Lauren, Steward, Oswald, Zheng, Binhai, and He, Zhigang

Subjects
Biomedical and Clinical Sciences, Neurosciences, Aging, Animals, Axons, Cervical Vertebrae, Intracellular Signaling Peptides and Proteins, Medulla Oblongata, Mice, Mice, Transgenic, Nerve Regeneration, Neurons, PTEN Phosphohydrolase, Protein Serine-Threonine Kinases, Pyramidal Tracts, Somatosensory Cortex, Spinal Cord, Spinal Cord Injuries, Synapses, TOR Serine-Threonine Kinases, Thoracic Vertebrae, Psychology, Cognitive Sciences, Neurology & Neurosurgery, Biological psychology
Abstract

Despite the essential role of the corticospinal tract (CST) in controlling voluntary movements, successful regeneration of large numbers of injured CST axons beyond a spinal cord lesion has never been achieved. We found that PTEN/mTOR are critical for controlling the regenerative capacity of mouse corticospinal neurons. After development, the regrowth potential of CST axons was lost and this was accompanied by a downregulation of mTOR activity in corticospinal neurons. Axonal injury further diminished neuronal mTOR activity in these neurons. Forced upregulation of mTOR activity in corticospinal neurons by conditional deletion of Pten, a negative regulator of mTOR, enhanced compensatory sprouting of uninjured CST axons and enabled successful regeneration of a cohort of injured CST axons past a spinal cord lesion. Furthermore, these regenerating CST axons possessed the ability to reform synapses in spinal segments distal to the injury. Thus, modulating neuronal intrinsic PTEN/mTOR activity represents a potential therapeutic strategy for promoting axon regeneration and functional repair after adult spinal cord injury.

Published
2010

22. Immune checkpoint inhibitor-associated myocarditis: from pathophysiology to rechallenge of therapy – a narrative review

Author

Tedeschi, Andrea, primary, Camilli, Massimiliano, additional, Ammirati, Enrico, additional, Gentile, Piero, additional, Palazzini, Matteo, additional, Conti, Nicolina, additional, Verde, Alessandro, additional, Masciocco, Gabriella, additional, Foti, Grazia, additional, Giannattasio, Cristina, additional, and Garascia, Andrea, additional

Published
2023
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23. Immune checkpoint inhibitor-associated myocarditis: from pathophysiology to rechallenge of therapy - a narrative review

Author

Tedeschi, A, Camilli, M, Ammirati, E, Gentile, P, Palazzini, M, Conti, N, Verde, A, Masciocco, G, Foti, G, Giannattasio, C, Garascia, A, Tedeschi, Andrea, Camilli, Massimiliano, Ammirati, Enrico, Gentile, Piero, Palazzini, Matteo, Conti, Nicolina, Verde, Alessandro, Masciocco, Gabriella, Foti, Grazia, Giannattasio, Cristina, Garascia, Andrea, Tedeschi, A, Camilli, M, Ammirati, E, Gentile, P, Palazzini, M, Conti, N, Verde, A, Masciocco, G, Foti, G, Giannattasio, C, Garascia, A, Tedeschi, Andrea, Camilli, Massimiliano, Ammirati, Enrico, Gentile, Piero, Palazzini, Matteo, Conti, Nicolina, Verde, Alessandro, Masciocco, Gabriella, Foti, Grazia, Giannattasio, Cristina, and Garascia, Andrea

Abstract

Even if immune checkpoint inhibitors have revolutionized the landscape of cancer therapy, their use may be complicated by immune-related adverse events. Among these, myocarditis is the most severe complication. The clinical suspicion often arises after clinical symptoms onset and increase in cardiac biomarkers or electrocardiographic manifestations. Echocardiography and cardiac magnetic resonance imaging are recommended for each patient. However, since they may be misleadingly normal, endomyocardial biopsy remains the gold standard for establishing the diagnosis. Until now, treatment has been based on glucocorticoids even if increasing interest has risen in other immunosuppressive agents. Although myocarditis currently imposes immunotherapy discontinuation, case reports have suggested a safety rechallenge in low-grade myocarditis paving the way for further studies to respond to this unmet clinical need.

Published
2023

26. 108 PHEOCHROMOCYTOMA-INDUCED CARDIOGENIC SHOCK: A MULTICENTRE ANALYSIS OF CLINICAL PROFILES, MANAGEMENT AND OUTCOMES

Author

Angelis, Elena De, primary, Bochaton, Thomas, additional, Ammirati, Enrico, additional, Tedeschi, Andrea, additional, Polito, Maria Vincenza, additional, Pieroni, Maurizio, additional, Merlo, Marco, additional, Van De Heyning, Caroline M, additional, Cipriani, Alberto, additional, Camilli, Massimiliano, additional, Sanna, Tommaso, additional, Cabassi, Aderville, additional, Piepoli, Massimo F, additional, Sinagra, Gianfranco, additional, Bonnefoy-cudraz, Eric, additional, Ravera, Amelia, additional, and Hayek, Ahmad, additional

Published
2022
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33. Takotsubo syndrome after BNT162b2 mRNA Covid-19 vaccine: Emotional or causative relationship with vaccination?

Author

Tedeschi, Andrea, primary, Camilli, Massimiliano, additional, Ianni, Umberto, additional, Tavecchia, Giovanni, additional, Palazzini, Matteo, additional, Cartella, Iside, additional, Gentile, Piero, additional, Quattrocchi, Giuseppina, additional, Maria Spanò, Francesca, additional, Cipriani, Manlio, additional, Garascia, Andrea, additional, and Ammirati, Enrico, additional

Published
2022
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35. Harnessing cortical plasticity via gabapentinoid administration promotes recovery after stroke

Author

Tedeschi, Andrea, primary, Larson, Molly J E, additional, Zouridakis, Antonia, additional, Mo, Lujia, additional, Bordbar, Arman, additional, Myers, Julia M, additional, Qin, Hannah Y, additional, Rodocker, Haven I, additional, Fan, Fan, additional, Lannutti, John J, additional, McElroy, Craig A, additional, Nimjee, Shahid M, additional, Peng, Juan, additional, Arnold, W David, additional, Moon, Lawrence D F, additional, and Sun, Wenjing, additional

Published
2022
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36. Caspase-4/11 exacerbates disease severity in SARS–CoV-2 infection by promoting inflammation and immunothrombosis

Author

Eltobgy, Mostafa M., primary, Zani, Ashley, additional, Kenney, Adam D., additional, Estfanous, Shady, additional, Kim, Eunsoo, additional, Badr, Asmaa, additional, Carafice, Cierra, additional, Daily, Kylene, additional, Whitham, Owen, additional, Pietrzak, Maciej, additional, Webb, Amy, additional, Kawahara, Jeffrey, additional, Eddy, Adrian C., additional, Denz, Parker, additional, Lu, Mijia, additional, KC, Mahesh, additional, Peeples, Mark E., additional, Li, Jianrong, additional, Zhu, Jian, additional, Que, Jianwen, additional, Robinson, Richard, additional, Rosas Mejia, Oscar, additional, Rayner, Rachael E., additional, Hall-Stoodley, Luanne, additional, Seveau, Stephanie, additional, Gavrilin, Mikhail A., additional, Zhang, Xiaoli, additional, Thomas, Jeronay, additional, Kohlmeier, Jacob E., additional, Suthar, Mehul S., additional, Oltz, Eugene, additional, Tedeschi, Andrea, additional, Robledo-Avila, Frank H., additional, Partida-Sanchez, Santiago, additional, Hemann, Emily A., additional, Abdelrazik, Eman, additional, Forero, Adriana, additional, Nimjee, Shahid M., additional, Boyaka, Prosper N., additional, Cormet-Boyaka, Estelle, additional, Yount, Jacob S., additional, and Amer, Amal O., additional

Published
2022
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38. Caspase-4/11 exacerbates disease severity in SARS-CoV-2 infection by promoting inflammation and thrombosis

Author

Eltobgy, Mostafa, primary, Zani, Ashley, additional, Kenney, Adam D., additional, Estfanous, Shady, additional, Kim, Eunsoo, additional, Badr, Asmaa, additional, Carafice, Cierra, additional, Daily, Kylene, additional, Whitham, Owen, additional, Pietrzak, Maciej, additional, Webb, Amy, additional, Kawahara, Jeffrey, additional, Eddy, Adrian C., additional, Denz, Parker, additional, Lu, Mijia, additional, Mahesh, KC, additional, Peeples, Mark E., additional, Li, Jianrong, additional, Zhu, Jian, additional, Que, Jianwen, additional, Robinson, Richard, additional, Mejia, Oscar Rosas, additional, Rayner, Rachael E., additional, Hall-Stoodley, Luanne, additional, Seveau, Stephanie, additional, Gavrilin, Mikhail A., additional, Tedeschi, Andrea, additional, Partida-Sanchez, Santiago, additional, Roberto, Frank, additional, Hemann, Emily A., additional, Abdelrazik, Eman, additional, Forero, Adriana, additional, Nimjee, Shahid M., additional, Boyaka, Prosper, additional, Cormet-Boyaka, Estelle, additional, Yount, Jacob S., additional, and Amer, Amal O., additional

Published
2021
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45. Biodegradable oxygen biosensors via electrospinning

Author

Cybyk, Daniel B., primary, Reinsch, Bonnie M., additional, Presley, Kayla F., additional, Schweller, Ryan M., additional, Tedeschi, Andrea, additional, Burns, Teresa, additional, Chaparro, Francisco J., additional, Ly, Jack T., additional, Dalton, Matthew J., additional, Lozano, Monica, additional, Grusenmeyer, Tod A., additional, and Lannutti, John J., additional

Published
2020
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