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3. Dual latent tuberculosis screening with tuberculin skin tests and QuantiFERON-TB assays before TNF-α inhibitor initiation in children in Spain

Author

Calzada-Hernández, Joan, Anton, Jordi, Martín de Carpi, Javier, López-Montesinos, Berta, Calvo, Inmaculada, Donat, Ester, Núñez, Esmeralda, Blasco Alonso, Javier, Mellado, María José, Baquero-Artigao, Fernando, Leis, Rosaura, Vegas-Álvarez, Ana María, Medrano San Ildefonso, Marta, Pinedo-Gago, María del Carmen, Eizaguirre, Francisco Javier, Tagarro, Alfredo, Camacho-Lovillo, Marisol, Pérez-Gorricho, Beatriz, Gavilán-Martín, César, Guillén, Sara, Sevilla-Pérez, Belén, Peña-Quintana, Luis, Mesa-Del-Castillo, Pablo, Fortuny, Clàudia, Tebruegge, Marc, and Noguera-Julian, Antoni

Published
2023
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5. Contributors

Author

Abzug, Mark J., primary, Adderson, Elisabeth E., additional, Agarwal, Aastha, additional, Agwu, Allison L., additional, Albenberg, Lindsey, additional, Albert, Jonathan, additional, Alby, Kevin, additional, Aldrovandi, Grace M., additional, Allen, Upton D., additional, Alvarez-Hernndez, Gerardo, additional, Ampofo, Krow, additional, Anderson, Evan J., additional, Appiah, Grace D., additional, Ardura, Monica I., additional, Arnon, Stephen S., additional, Aronson, Naomi E., additional, Arvin, Ann M., additional, Ashkenazi, Shai, additional, Ashkenazi-Hoffnung, Liat, additional, Asturias, Edwin J., additional, Aukstuolis, Kestutis, additional, Badalyan, Vahe, additional, Baker, Carol J., additional, Balakrishnan, Karthik, additional, Barnett, Elizabeth D., additional, Bechtel, Kirsten, additional, Benitz, William E., additional, Berkovich, Rachel, additional, Berman, David M., additional, Bialek, Stephanie R., additional, Bijker, Else M., additional, Bizzarro, Matthew J., additional, Bloch, Karen C., additional, Bocchini, Joseph A., additional, Boyce, Thomas G., additional, Bradley, John S., additional, Bratcher, Denise F., additional, Braverman, Paula K., additional, Brook, Itzhak, additional, Brown, Kevin Edward, additional, Bryant, Kristina P., additional, Camacho-Gonzalez, Andres F., additional, Caete-Gibas, Connie F., additional, Cantey, Joseph B., additional, Cantey, Paul, additional, Cardemil, Cristina V., additional, Caserta, Mary T., additional, Castagnini, Luis A., additional, Cataldi, Jessica R., additional, Chadwick, Ellen Gould, additional, Chancey, Rebecca J., additional, Cherry, Cara C., additional, Chiang, Silvia S., additional, Choi, Mary, additional, Christenson, John C., additional, Coffin, Susan E., additional, Cohn, Amanda, additional, Contopoulos-Ioannidis, Despina G., additional, Conway, James H., additional, Cortese, Margaret M., additional, Creech, C. Buddy, additional, Crews, Jonathan D., additional, Curtis, Donna, additional, Curtis, Nigel, additional, Danziger-Isakov, Lara A., additional, Darville, Toni, additional, Dasch, Gregory A., additional, Daskalaki, Irini, additional, Davies, H. Dele, additional, Dawood, Fatimah S., additional, Day, J. Christopher, additional, Teresa de la Morena, M., additional, DeMuri, Gregory P., additional, Despommier, Dickson D., additional, Dodson, Daniel S., additional, Dolgner, Stephen J., additional, Dunn, Clinton, additional, Dyal, Jonathan, additional, Edwards, Kathryn M., additional, Edwards, Morven S., additional, Eichenfield, Dawn Z., additional, Eichenfield, Lawrence F., additional, Elston, Dirk M., additional, Emerson, Beth, additional, Enane, Leslie A., additional, Ephros, Moshe, additional, Erdem, Guliz, additional, Eremeeva, Marina E., additional, Esposito, Douglas H., additional, Farley, Monica M., additional, Feingold, Anat R., additional, Feja, Kristina N., additional, Finn, Adam, additional, Fischer, Marc, additional, Fisher, Brian T., additional, Fisher, Randall G., additional, Flynn, Patricia Michele, additional, Foster, Monique A., additional, Fox, LeAnne M., additional, Frank, Michael M., additional, Fredrick, Douglas R., additional, Frenck, Robert W., additional, Gaensbauer, James, additional, Gans, Hayley A., additional, Gauthier, Gregory M., additional, Gavigan, Patrick, additional, Gerber, Jeffrey S., additional, Gernez, Yael, additional, Gigliotti, Francis, additional, Gilger, Mark A., additional, Glaser, Carol A., additional, Gould, Jane M., additional, Graziano, James, additional, Green, Amanda M., additional, Green, Michael, additional, Griffin, Daniel, additional, Griffin, Patricia M., additional, Griffith, David C., additional, Gupta, Piyush, additional, Gutelius, Bruce J., additional, Gutman, Julie R., additional, Hall, Aron J., additional, Hamdy, Rana F., additional, Han, Jin-Young, additional, Handy, Lori K., additional, Hanisch, Benjamin, additional, Harper, Marvin B., additional, Harris, Aaron M., additional, Harrison, Christopher J., additional, Haslam, David B., additional, Haston, Julia C., additional, Hawkes, Sarah.J., additional, Heald-Sargent, Taylor, additional, Hendley, J. Owen, additional, Hersh, Adam L., additional, Hilinski, Joseph A., additional, Hills, Susan L., additional, Hong, David K., additional, Hotez, Peter J., additional, Hsu, Katherine K., additional, Huang, Felicia Scaggs, additional, Hunstad, David A., additional, Hunt, W. Garrett, additional, Hwang, Loris Y., additional, Ilboudo, Christelle M., additional, Jaggi, Preeti, additional, Jean, Sophonie, additional, Jhaveri, Ravi, additional, Jirk-Pomajbkov, Kateina, additional, Kadry, Nadia A., additional, Kamb, Mary L., additional, Kapadia, Ronak K., additional, Katz, Ben Z., additional, Katz, Sophie E., additional, Kaur, Ishminder, additional, Kersh, Gilbert J., additional, Khan, Muhammad Ali, additional, Khurana, Ananta, additional, Kimberlin, David W., additional, Klein, Bruce, additional, Kobayashi, Miwako, additional, Kociolek, Larry K., additional, Koh, Andrew Y., additional, Kotloff, Karen L., additional, Kroger, Andrew T., additional, Kronman, Matthew P., additional, Lalor, Leah, additional, Lauren, Christine T., additional, Leber, Amy, additional, Leshem, Eyal, additional, Lewis, David B., additional, Livingston, Robyn A., additional, Llata, Eloisa, additional, Lloyd, Kevin, additional, Loh, Katrina, additional, Long, Sarah S., additional, Lopman, Benjamin A., additional, Lucero, Yalda C., additional, Lugo, Debra J., additional, Lujn-Zilbermann, Jorge, additional, Maldonado, Yvonne A., additional, Manaloor, John J., additional, Manthiram, Kalpana, additional, Martin, Stacey W., additional, Mathew, Roshni, additional, Mazzulli, Tony, additional, McFarland, Elizabeth J., additional, McGann, Kathleen A., additional, McNamara, Lucy A., additional, Meislich, Debrah, additional, Meissner, H. Cody, additional, Mejias, Asuncion, additional, Mertsola, Jussi, additional, Messacar, Kevin, additional, Mhaissen, Mohammad Nael, additional, Michaels, Marian G., additional, Miller, Melissa B., additional, Miller-Handley, Hilary, additional, Mintz, Eric, additional, Mohan, Parvathi, additional, Montgomery, Susan P., additional, Montoya, Jose G., additional, Moorman, Anne C., additional, Moro, Pedro L., additional, Moscicki, Anna-Barbara, additional, Muller, William J., additional, Myers, Angela L., additional, Nadel, Simon, additional, Nayak, Jennifer Lynn, additional, Neely, Michael Noel, additional, Neil, Karen P., additional, Nelson, Christina A., additional, Nelson, Noele P., additional, Nichols, Megin, additional, Nicholson, William, additional, Nopper, Amy Jo, additional, Norton, Laura E., additional, Ochoa, Theresa J., additional, Olarte, Liset, additional, Onarecker, Timothy R., additional, Orenstein, Walter A., additional, ORyan, Miguel, additional, Otto, William R., additional, Ouellette, Christopher P., additional, Paddock, Christopher D., additional, Palazzi, Debra L., additional, Panuganti, Suresh Kumar, additional, Pappas, Diane E., additional, Paret, Michal, additional, Pastula, Daniel M., additional, Patterson, Thomas F., additional, Petersen, Brett W., additional, Petrosyan, Mikael, additional, Pickering, Larry K., additional, Pindyck, Talia, additional, Pinninti, Swetha, additional, Pittet, Laure F., additional, Planet, Paul J., additional, Pollard, Andrew J., additional, Posfay-Barbe, Klara M., additional, Poulsen, Casper S., additional, Poutanen, Susan M., additional, Powers, Ann M., additional, Prasanphanich, Nina Salinger, additional, Pritt, Bobbi S., additional, Prober, Charles G., additional, Puar, Neha, additional, Quilter, Laura A.S., additional, Ramilo, Octavio, additional, Rao, Suchitra, additional, Ratner, Adam J., additional, Rawstron, Sarah A., additional, Read, Jennifer S., additional, Relich, Ryan F., additional, Reller, Megan E., additional, Robinson, Candice L., additional, Romero, Jos R., additional, Rosen, David A., additional, Ross, Shannon A., additional, Rours, G. Ingrid J.G., additional, Rowe, Peter C., additional, Rowley, Anne H., additional, Rubin, Lorry G., additional, Ryan, Edward T., additional, Sacharok, Alexandra, additional, Sandora, Thomas J., additional, Sapp, Sarah G.H., additional, Sardana, Kabir, additional, Sauberan, Jason B., additional, Schaffzin, Joshua K., additional, Schillie, Sarah, additional, Schuster, Jennifer E., additional, Schwartz, Kevin L., additional, Sederdahl, Bethany K., additional, Serpa-Alvarez, Jose, additional, Shah, Kara N., additional, Shah, Samir S., additional, Shaikh, Nader, additional, Shane, Andi L., additional, Shapiro, Eugene D., additional, Shaw, Jana, additional, Shetty, Avinash K., additional, Shope, Timothy R., additional, Dairiki Shortliffe, Linda M., additional, Shulman, Stanford T., additional, Shust, Gail F., additional, Siberry, George Kelly, additional, Siegel, Jane D., additional, Siegel, Robert David, additional, Simonsen, Kari A., additional, Singh, Upinder, additional, Smith, Christiana, additional, Smith, Lauren L., additional, Song, Eunkyung, additional, Souder, Emily, additional, Spearman, Paul, additional, St. Geme, Joseph W., additional, Staat, Mary Allen, additional, Staples, J. Erin, additional, Starke, Jeffrey R., additional, Statler, Victoria A., additional, Steinbach, William J., additional, Stensvold, Christen Rune, additional, Stokes, Erin K., additional, Stoner, Bradley P., additional, Storch, Gregory A., additional, Straily, Anne, additional, Sullivan, Kathleen E., additional, Swanson, Douglas S., additional, Tanz, Robert R., additional, Taormina, Gillian, additional, Tate, Jacqueline E., additional, Taveras, Jeanette, additional, Tebruegge, Marc, additional, Teshale, Eyasu H., additional, Thompson, George R., additional, Thompson-Stone, Robert, additional, Thomsen, Isaac, additional, Thomson, Richard B., additional, Thorell, Emily A., additional, Tien, Vivian, additional, Tobin, Nicole H., additional, Toltzis, Philip, additional, Treat, James, additional, Troy, Stephanie B., additional, Van Dvke, Russell B., additional, Vaz, Louise Elaine, additional, Vijayan, Vini, additional, Vodzak, Jennifer, additional, Wagner, Thor A., additional, Wald, Ellen R., additional, Wallihan, Rebecca, additional, Wang, Huanyu, additional, Wangu, Zoon, additional, Washam, Matthew, additional, Waters, Valerie, additional, Watson, Joshua R., additional, Weatherhead, Jill E., additional, Weinberg, Geoffrey A., additional, Weng, Mark K., additional, Wiederhold, Nathan P., additional, Wiesenfeld, Harold C., additional, Williams, Cydni, additional, Williams, John V., additional, Willoughby, Rodney E., additional, Wittler, Robert R., additional, Wood, James B., additional, Woods, Charles Reece, additional, Workowski, Kimberly A., additional, Wright, Terry W., additional, Wu, Hsi-Yang, additional, Xu, Huan, additional, Yagupsky, Pablo, additional, Yi, Jumi, additional, Yoder, Jonathan, additional, Young, Edward J., additional, Zaenglein, Andrea L., additional, Zimmermann, Petra, additional, and Zong, Wenjing, additional

Published
2023
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7. The Value of the Second QuantiFERON-TB Gold-Plus Antigen Tube at Diagnosis and at Treatment Completion in Spanish Children With Tuberculosis

Author

Soler-Garcia, Aleix, Gamell, Anna, Monsonís, Manuel, Korta-Murua, José Javier, Espiau, María, Rincón-López, Elena, Rodríguez-Molino, Paula, Pérez-Porcuna, Tomàs, Bustillo-Alonso, Matilde, Santiago, Begoña, Tebruegge, Marc, Noguera-Julian, Antoni, AZURMENDI-GUNDÍN, Nerea, FORTUNY, Clàudia, COLINO, Elena, GÓMEZ-PASTRANA, David, MONTERO, María, PEROMINGO, Estrella, LAFUENTE-HIDALGO, Miguel, MOLINER, Elisenda, VALMANYA, Teresa, MINGUELL-DOMINGO, Laura, FENOY, Marina, VELÁZQUEZ, Marta, SOLER-CAMPINS, Maria Queralt, GARCIA, Lourdes, LAHOZ, Rebeca, CALAVIA, Olga, PASCUAL, María Teresa, RIUS, Neus, TÓRTOLA, Teresa, SORIANO-ARANDES, Antoni, MARTÍN-NALDA, Andrea, SOLER-PALACÍN, Pere, LILLO, Miguel, DAPENA, Marta, LÓPEZ-MEDINA, Eva María, PIQUERAS, Ana Isabel, RUIZ-JIMÉNEZ, Marta, SOTO-SÁNCHEZ, Beatriz, HERNÁNDEZ, Ángel, RUIZ-SERRANO, María Jesús, COBO-VÁZQUEZ, Elvira, SANTOS, María del Mar, HERNÁNDEZ-SAMPELAYO, Teresa, TAGARRO, Alfredo, MÉNDEZ-ECHEVARRÍA, Ana, MELLADO, María José, BAQUERO-ARTIGAO, Fernando, CALVO, Cristina, SAINZ, Talía, ÁLVAREZ, Javier, GARCÍA ASCASO, Marta Taida, VILLALOBOS, Enrique, PÉREZ-GORRICHO, Beatriz, GARCÍA-GARCÍA, María Luz, GARROTE-LLANOS, Maria Isabel, REMENTERÍA, Joseba, SÁNCHEZ-TORRENT, Laia, GARCÍA-HORTELANO, Milagros, and LOBATO, Zulema

Published
2023
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9. Empfehlungen der Österreichischen Gesellschaft für Kinder- und Jugendheilkunde zur Prophylaxe einer RSV-Infektion mit Nirsevimab.

Author

Resch, Bernhard, Strenger, Volker, Zacharasiewicz, Angela, Zwiauer, Karl, Berger, Angelika, Zacharasiewcz, Angela, Redlberger-Fritz, Monika, Wald, Martin, Kiechl-Kohlendorfer, Ursula, Köstenberger, Martin, Dornbusch, Hans Jürgen, Voitl, Peter, and Tebruegge, Marc

Abstract

Copyright of Pädiatrie & Pädologie is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024
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10. Tuberculosis disease in immunocompromised children and adolescents: a pTBnet multi-centre case-control study

Author

Rodríguez-Molino, Paula, primary, Tebruegge, Marc, additional, Noguera-Julian, Antoni, additional, Neth, Olaf, additional, Fidler, Katy, additional, Brinkmann, Folke, additional, Sainz, Talia, additional, Ivaskeviciene, Inga, additional, Ritz, Nicole, additional, Brito, Maria Joao, additional, Milheiro Silva, Tiago, additional, Chechenieva, Vira, additional, Serdiuk, Maryna, additional, Lancella, Laura, additional, Russo, Cristina, additional, Soler-García, Aleix, additional, Navarro, Maria Luisa, additional, Krueger, Renate, additional, Feiterna-Sperling, Cornelia, additional, Starshinova, Anna, additional, Hiteva, Antonina, additional, Hoffmann, Anna, additional, Kalibatas, Paulius, additional, Lo Vecchio, Andrea, additional, Scarano, Sara Maria, additional, Bustillo, Matilde, additional, Blázquez Gamero, Daniel, additional, Espiau, María, additional, Buonsenso, Danilo, additional, Falcón, Lola, additional, Turnbull, Louise, additional, Colino, Elena, additional, Rueda, Santiago, additional, Buxbaum, Charlotte, additional, Carazo, Begoña, additional, Alvarez, Cristina, additional, Dapena, Marta, additional, Piqueras, Anabel, additional, Velizarova, Svetlana, additional, Ozere, Iveta, additional, Götzinger, Florian, additional, Pareja, Marta, additional, Garrote Llanos, Maria Isabel, additional, Soto, Beatriz, additional, Rodríguez Martín, Sonia, additional, Korta, Jose Javier, additional, Pérez-Gorricho, Beatriz, additional, Herranz, Mercedes, additional, Hernández-Bartolomé, Ángel, additional, Díaz-Almirón, Mariana, additional, Kohns Vasconcelos, Malte, additional, Ferreras-Antolín, Laura, additional, and Santiago-García, Begoña, additional

Published
2024
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11. Preventing tuberculosis in paediatric kidney transplant recipients: is there a role for BCG immunisation pre-transplantation in low tuberculosis incidence countries?

Author

Bamford, Alasdair, Dixon, Garth, Klein, Nigel, Marks, Stephen D., Ritz, Nicole, Welch, Steven B., and Tebruegge, Marc

Subjects
Children -- Surgery, Tuberculosis -- Prevention, Preoperative care -- Patient outcomes, BCG vaccination -- Evaluation, Health
Abstract

The risk of tuberculosis (TB) disease is increased in children with chronic kidney disease (CKD), even higher in stage 5 CKD/kidney failure and especially high after kidney transplantation due to immunosuppression. TB disease may follow recent primary infection, or result from reactivation of latent infection. Reactivation is more common in adults, while progression following primary infection makes up a greater proportion of disease in children. Recommendations for preventing TB disease in some low TB incidence countries have previously included offering Bacillus Calmette-Guérin (BCG) vaccine to all children listed for kidney transplant if they had not received this as part of previous national immunisation programmes. Based on the available evidence, we recommend modifying this practice, focusing instead on awareness of risk factors for TB exposure, infection and disease and the use of appropriate testing strategies to identify and treat TB infection and disease., Author(s): Alasdair Bamford [sup.1] [sup.2] , Garth Dixon [sup.3] [sup.2] , Nigel Klein [sup.1] [sup.2] , Stephen D. Marks [sup.4] [sup.2] , Nicole Ritz [sup.5] [sup.6] , Steven B. Welch [...]

Published
2021
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12. Interferon-Gamma Release Assays Differentiate between Mycobacterium avium Complex and Tuberculous Lymphadenitis in Children

Author

Vallmanya, Teresa, Minguell, Laura, Martín-Nalda, Andrea, Soler-Palacín, Pere, Espiau, María, Lobato, Zulema, Garcia, Lourdes, Velázquez, Marta, Herranz, Mercedes, Arroyo, Mireia, Gutiérrez, Carmelo, Gavilán, César, Piqueras, Ana Isabel, Martinón-Torres, Federico, Villanueva, Isabel, Rueda, Santiago, Ramos, Marta Illán, Morales, Ana, ROA, Miguel, Pérez-Gorricho, Beatriz, Pinto, Enrique Villalobos, Sanz-Santaeufemia, Francisco José, Álvarez, Javier, Álvarez, Cristina, Guarch, Borja, Montero, María, Cilleruelo, María José, Otheo, Enrique, Calvo, Cristina, Korta Murua, José Javier, Mellado, María José, Rojo, Pablo, Moreno-Pérez, David, Neth, Olaf, Santos, Mar, Hernández, Teresa, Hidalgo, Miguel Lafuente, Antonio Cepillo, Martínez-Planas, Aina, Baquero-Artigao, Fernando, Santiago, Begoña, Fortuny, Clàudia, Méndez-Echevarría, Ana, Del Rosal, Teresa, Bustillo-Alonso, Matilde, Gale, Inés, Guerrero, Carmelo, Blázquez-Gamero, Daniel, Canet, Anna, Lillo, Miguel, Calavia, Olga, Núñez Cuadros, Esmeralda, Falcón-Neyra, Lola, Soriano-Arandes, Antoni, Van Ingen, Jakko, Tebruegge, Marc, and Noguera-Julian, Antoni

Published
2021
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13. Long COVID in Children and Adolescents: A Critical Review.

Author

Rothensteiner, Maria, Leeb, Franziska, Götzinger, Florian, Tebruegge, Marc, and Zacharasiewicz, Angela

Subjects
CARDIOVASCULAR diseases, DISEASE duration, POST-acute COVID-19 syndrome, DISEASE prevalence, AGE distribution, RESPIRATORY diseases, NEUROBEHAVIORAL disorders, PSYCHOSES, DISEASE risk factors, SYMPTOMS, ADOLESCENCE, CHILDREN
Abstract

(1) Background: Data on persisting symptoms after SARS-CoV-2 infection in children and adolescents are conflicting. Due to the absence of a clear pathophysiological correlate and a definitive diagnostic test, the diagnosis of Long COVID currently rests on consensus definitions only. This review aims to summarise the evidence regarding Long COVID in children and adolescents, incorporating the latest studies on this topic. (2) Methods: We designed a comprehensive search strategy to capture all relevant publications using Medline via the PubMed interface, with the initial literature search conducted in April 2023. To be included, publications had to present original data and include >50 participants with Long COVID symptoms aged between 0 and18 years. (3) Results: A total of 51 studies met the inclusion criteria, with most studies originating from Europe (n = 34; 66.7%), followed by the Americas (n = 8; 15.7%) and Asia (n = 7; 13.7%). Various study designs were employed, including retrospective, cross-sectional, prospective, or ambispective approaches. Study sizes varied significantly, with 18/51 studies having fewer than 500 participants. Many studies had methodological limitations: 23/51 (45.1%) studies did not include a control group without prior COVID-19 infection. Additionally, a considerable number of papers (33/51; 64.7%) did not include a clear definition of Long COVID. Other limitations included the lack of PCR- or serology-based confirmation of SARS-CoV-2 infection in the study group. Across different studies, there was high variability in the reported prevalence of Long COVID symptoms, ranging from 0.3% to 66.5%, with the majority of studies included in this review reporting prevalences of approximately 10–30%. Notably, the two studies with the highest prevalences also reported very high prevalences of Long COVID symptoms in the control group. There was a relatively consistent trend for Long COVID prevalence to decline substantially over time. The prevalence of Long COVID appeared to differ across different paediatric age groups, with teenagers being more commonly affected than younger children. Furthermore, data suggest that children and adolescents are less commonly affected by Long COVID compared to adults. In children and adolescents, Long COVID is associated with a very broad range of symptoms and signs affecting almost every organ system, with the respiratory, cardiovascular, and neuropsychiatric systems being most commonly affected. (4) Conclusions: The heterogeneity and limitations of published studies on Long COVID in children and adolescents complicate the interpretation of the existing data. Future studies should be rigorously designed to address unanswered questions regarding this complex disease. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Tuberculosis Disease in Immunocompromised Children and Adolescents: A Pediatric Tuberculosis Network European Trials Group Multicenter Case-control Study.

Author

Rodríguez-Molino, Paula, Tebruegge, Marc, Noguera-Julian, Antoni, Neth, Olaf, Fidler, Katy, Brinkmann, Folke, Sainz, Talia, Ivaskeviciene, Inga, Ritz, Nicole, Brito, Maria Joao, Silva, Tiago Milheiro, Chechenieva, Vira, Serdiuk, Maryna, Lancella, Laura, Russo, Cristina, Soler-García, Aleix, Navarro, Maria Luisa, Krueger, Renate, Feiterna-Sperling, Cornelia, and Starshinova, Anna

Subjects
*TUBERCULOSIS diagnosis, *PREVENTION of communicable diseases, *TUBERCULOSIS epidemiology, *HIV infection complications, *RISK assessment, *DISEASE duration, *RESEARCH funding, *IMMUNOCOMPROMISED patients, *TREATMENT effectiveness, *DESCRIPTIVE statistics, *ANTITUBERCULAR agents, *PEDIATRICS, *ODDS ratio, *RESEARCH, *CASE-control method, *TUBERCULIN test, *CONFIDENCE intervals, *TUBERCULOSIS, *IMMUNOSUPPRESSION, *ADOLESCENCE, *CHILDREN
Abstract

Background In high-resource settings, the survival of children with immunocompromise (IC) has increased and immunosuppressive therapies are increasingly being used. This study aimed to determine the clinical characteristics, performance of diagnostic tools, and outcome of IC children with tuberculosis (TB) in Europe. Methods Multicenter, matched case-control study within the Pediatric Tuberculosis Network European Trials Group, capturing TB cases <18 years diagnosed 2000–2020. Results A total of 417 TB cases were included, comprising 139 children who are IC (human immunodeficiency virus, inborn errors of immunity, drug-induced immunosuppression, and other immunocompromising conditions) and 278 non-IC children as controls. Nonrespiratory TB was more frequent among cases than controls (32.4% vs 21.2%; P =.013). Patients with IC had an increased likelihood of presenting with severe disease (57.6% vs 38.5%; P <.001; odds ratio [95% confidence interval], 2.073 [1.37–3.13]). Children with IC had higher rates of false-negative tuberculin skin test (31.9% vs 6.0%; P <.001) and QuantiFERON-TB Gold assay (30.0% vs 7.3%; P <.001) results at diagnosis. Overall, the microbiological confirmation rate was similar in IC and non-IC cases (58.3% vs 49.3%; P =.083). Although the mortality in children with IC was <1%, the rate of long-term sequelae was significantly higher than in non-IC cases (14.8% vs 6.1%; P =.004). Conclusions Children with IC and TB in Europe have increased rates of nonrespiratory TB, severe disease, and long-term sequelae. Immune-based TB tests have poor sensitivity in those children. Future research should focus on developing improved immunological TB tests that perform better in patients with IC, and determining the reasons for the increased risk of long-term sequelae, with the aim to design preventive management strategies. [ABSTRACT FROM AUTHOR]

Published
2024
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21. Probable Vertical Transmission of SARS-CoV-2 Infection

Author

Demirjian, Alicia, Singh, Cheentan, Tebruegge, Marc, Herbert, Rachel, Draz, Nehal, Mirfenderesky, Mariyam, Jones, Victoria, Hinstridge, Peter, Seneviratne, Ranjika, Myers, Richard, Ellis, Joanna, Miah, Shahjahan, Meadows, Christopher IS, Kenny, Julia, Alonso, Alejandra, Handforth, Jennifer, Perkins, Shona, Butler, Mark, Blackburn, Frances, Douthwaite, Sam, Pillay, Deenan, Chand, Meera, and Zambon, Maria

Published
2020
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23. The impact of Bacille Calmette-Guérin shortage on immunisation practice and policies in Europe – A Paediatric Tuberculosis Network European Trials Group (ptbnet) survey

Author

Blázquez, Daniel, Bogyi, Matthias, Buonsenso, Danilo, Dreesman, Alexandra, Krivec, Uros, Mouchet, Françoise, Nejat, Sahar, Neth, Olaf, Pavić, Ivan, Ruga, Ezia, Schlags, Rupert, Soriano-Arandes, Antoni, Thee, Steffi, Tsolia, Maria, Velizarova, Svetlana, Kontturi, Antti, Santiago, Begoña, Tebruegge, Marc, von Both, Ulrich, Salo, Eeva, and Ritz, Nicole

Published
2016
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27. Contributors

Author

Abzug, Mark J., primary, Adderson, Elisabeth E., additional, Agwu, Allison L., additional, Alby, Kevin, additional, Aldrovandi, Grace M., additional, Allen, Upton D., additional, Alvarez-Hernández, Gerardo, additional, Ampofo, Krow, additional, Anderson, Evan J., additional, Anderson, Margot, additional, Antonara, Stella, additional, Ardura, Monica I., additional, Arguin, Paul M., additional, Arnold, John C., additional, Aronson, Naomi E., additional, Arvin, Ann M., additional, Ashkenazi, Shai, additional, Asturias, Edwin J., additional, Badalyan, Vahe, additional, Baker, Carol J., additional, Balakrishnan, Karthik, additional, Barros, Brittany S., additional, Barson, William J., additional, Bausch, Daniel G., additional, Bechtel, Kirsten, additional, Benjamin, Daniel K., additional, Berman, David M., additional, Blanco, David A., additional, Bloch, Karen C., additional, Blythe, Margaret J., additional, Bocchini, Joseph A., additional, Bowen, Anna, additional, Bowie, William R., additional, Boyce, Thomas G., additional, Bradley, John S., additional, Brady, Michael T., additional, Bratcher, Denise F., additional, Braverman, Paula K., additional, Bresee, Joseph, additional, Brook, Itzhak, additional, Brown, Kevin E., additional, Bryant, Kristina, additional, Buescher, E. Stephen, additional, Burns, Jane L., additional, Byington, Carrie L., additional, Camacho-Gonzalez, Andres F., additional, Cantey, Paul, additional, Carter, Bryan D., additional, Caserta, Mary T., additional, Castagnini, Luis A., additional, Cerini, Chiara, additional, Chadwick, Ellen Gould, additional, Chiang, Silvia S., additional, Christenson, John C., additional, Coffin, Susan E., additional, Collier, Melissa G., additional, Collins, Jennifer P., additional, Conklin, Laurie S., additional, Connelly, Beverly L., additional, Contopoulos-Ioannidis, Despina, additional, Conway, James H., additional, Cortese, Margaret M., additional, Cox, Elaine G., additional, Creech, C. Buddy, additional, Crews, Jonathan D., additional, Cunningham, Dennis J., additional, Curtis, Nigel, additional, Dailey, Natalie J.M., additional, Danziger-Isakov, Lara A., additional, Darville, Toni, additional, Dasch, Gregory A., additional, Daskalaki, Irini, additional, Daum, Robert S., additional, Davenport, Michael, additional, Davies, H. Dele, additional, Dawood, Fatimah S., additional, Day, J. Christopher, additional, de la Morena, Maite, additional, Demmler-Harrison, Gail J., additional, DeMuri, Gregory P., additional, Despommier, Dickson D., additional, Diefenbach, Karen A., additional, Edwards, Kathryn M., additional, Edwards, Morven S., additional, Eichenfield, Lawrence F., additional, Elston, Dirk M., additional, Emerson, Beth, additional, Ephros, Moshe, additional, Erdem, Guliz, additional, Eremeeva, Marina E., additional, Ericson, Jessica E., additional, Esposito, Douglas H., additional, Farley, Monica M., additional, Feingold, Anat R., additional, Feja, Kristina N., additional, Finn, Adam, additional, Fischer, Marc, additional, Flynn, Patricia M., additional, Fox, LeAnne M., additional, Frank, Michael M., additional, Fredrick, Douglas R., additional, Frenck, Robert W., additional, Friedlander, Sheila Fallon, additional, Gans, Hayley A., additional, Gauthier, Gregory M., additional, Gerber, Jeffrey S., additional, Gigliotti, Francis, additional, Gilger, Mark A., additional, Glaser, Carol A., additional, Goddard, Amanda F., additional, Gold, Benjamin D., additional, Gould, Jane M., additional, Green, Michael, additional, Greenberg, David, additional, Greywal, Tanya, additional, Griffin, Daniel, additional, Griffin, Patricia M., additional, Grom, Alexei A., additional, Gutierrez, Kathleen, additional, Gutman, Julie, additional, Guzman-Cottrill, Judith A., additional, Hall, Aron J., additional, Han, Jin-Young, additional, Harper, Marvin B., additional, Harris, Julie R., additional, Harrison, Christopher J., additional, Haslam, David B., additional, Hawkes, Sarah J., additional, Hendley, J. Owen, additional, Henry, Marion C.W., additional, Hilinski, Joseph A., additional, Hills, Susan L., additional, Holmberg, Scott D., additional, Holtzman, Deborah, additional, Hong, David K., additional, Hotez, Peter J., additional, Hsu, Katherine K., additional, Hunstad, David A., additional, Hwang, Loris Y., additional, Jackson, Mary Anne, additional, Jacobs, Richard F., additional, Jhaveri, Ravi, additional, Jirků-Pomajbíková, Kateřina, additional, Jones, Jeffrey L., additional, Karki, Mahima, additional, Karlowicz, M. Gary, additional, Katz, Ben Z., additional, Kaur, Ishminder, additional, Kersh, Gilbert J., additional, Keystone, Jay S., additional, Khan, Muhammad Ali, additional, Kimberlin, David W., additional, Kleiman, Martin B., additional, Klein, Bruce S., additional, Klontz, Karl, additional, Knust, Barbara, additional, Koh, Andrew Y., additional, Korgenski, E. Kent, additional, Krogstad, Paul, additional, Kutty, Preeta Krishnan, additional, Lauren, Christine T., additional, Lawrence, Hillary S., additional, Leber, Amy, additional, Lee, Grace M., additional, Leibovitz, Eugene, additional, Leshem, Eyal, additional, Levasseur, Stéphanie, additional, Lewis, David B., additional, Livingston, Robyn A., additional, Llata, Eloisa, additional, Long, Sarah S., additional, Lopman, Ben A., additional, Lucero, Yalda C., additional, Luján-Zilbermann, Jorge, additional, Luzuriaga, Katherine, additional, MacDonald, Noni E., additional, Maldonado, Yvonne A., additional, Manaloor, John, additional, Mani, Chitra S., additional, Manthiram, Kalpana, additional, Marshall, Gary S., additional, Martin, Stacey W., additional, Matanock, Almea, additional, Matiz, Catalina, additional, Mawle, Alison C., additional, Mazzulli, Tony, additional, McGann, Kathleen A., additional, McIntosh, Kenneth, additional, McNamara, Lucy A., additional, Meir, Michal, additional, Meislich, Debrah, additional, Meissner, H. Cody, additional, Meites, Elissa, additional, Mejías, Asunción, additional, Mertsola, Jussi, additional, Messacar, Kevin, additional, Mhaissen, Mohammed Nael, additional, Michaels, Marian G., additional, Miller, Melissa B., additional, Mintz, Eric D., additional, Modlin, John F., additional, Mohan, Parvathi, additional, Montgomery, Susan P., additional, Montoya, José G., additional, Moro, Pedro L., additional, Moscicki, Anna-Barbara, additional, Moss, R. Lawrence, additional, Myers, Angela L., additional, Nadel, Simon, additional, Neely, Michael N., additional, Neil, Karen P., additional, Nelson, Joanna, additional, Nelson, Noele P., additional, Nicholson, William L., additional, Nizet, Victor, additional, Nopper, Amy Jo, additional, Ochoa, Theresa J., additional, Orenstein, Walter A., additional, O'Ryan, Miguel, additional, Paddock, Christopher D., additional, Pall, Harpreet, additional, Panuganti, Suresh Kumar, additional, Pappas, Diane E., additional, Pass, Robert F., additional, Patterson, Thomas F., additional, Patton, Monica E., additional, Pelton, Stephen I., additional, Petersen, Brett W., additional, Pickering, Larry K., additional, Pinninti, Swetha, additional, Planet, Paul J., additional, Pollard, Andrew J., additional, Posfay-Barbe, Klara M., additional, Poulsen, Casper S., additional, Poutanen, Susan M., additional, Powers, Ann M., additional, Prober, Charles G., additional, Ramilo, Octavio, additional, Rangel, Shawn J., additional, Rao, Suchitra, additional, Rawstron, Sarah A., additional, Read, Jennifer S., additional, Reed, Michael D., additional, Relich, Ryan F., additional, Reller, Megan E., additional, Rellosa, Neil, additional, Rempe, Katherine A., additional, Reyes, Melissa A., additional, Rice-Townsend, Samuel E., additional, Richards, Frank O., additional, Romero, José R., additional, Rosen, David A., additional, Rostad, Christina A., additional, Rours, G. Ingrid J.G., additional, Routh, Janell A., additional, Rowley, Anne H., additional, Rubin, Lorry G., additional, Ryan, Edward T., additional, Saiman, Lisa, additional, Sammons, Julia S., additional, Sass, Laura, additional, Sauberan, Jason B., additional, Schillie, Sarah, additional, Schulert, Grant S., additional, Schuster, Jennifer E., additional, Schwartz, Kevin L., additional, Sederdahl, Bethany K., additional, Serpa, Jose A., additional, Shah, Kara N., additional, Shah, Samir S., additional, Shane, Andi L., additional, Shapiro, Eugene D., additional, Shaw, Jana, additional, Shetty, Avinash K., additional, Dairiki, Linda M., additional, Siberry, George Kelly, additional, Siegel, Jane D., additional, Siegel, Robert David, additional, Simonsen, Kari A., additional, Singh, Nalini, additional, Singh, Upinder, additional, Smith, P. Brian, additional, Snyder, John D., additional, Song, Eunkyung, additional, Sorrell, Jennifer L., additional, Souder, Emily, additional, St. Geme, Joseph W., additional, Staat, Mary Allen, additional, Staples, J. Erin, additional, Starke, Jeffrey R., additional, Steinbach, William J., additional, Stensvold, Christen R., additional, Stoner, Bradley P., additional, Strikas, Raymond A., additional, Strober, Jonathan B., additional, Sue, Paul K., additional, Sutton, Deanna A., additional, Swanson, Douglas, additional, Tate, Jacqueline E., additional, Tebruegge, Marc, additional, Teshale, Eyasu H., additional, Thompson, Amelia B., additional, Thompson, George R., additional, Thompson-Stone, Robert, additional, Thomson, Richard B., additional, Thorell, Emily A., additional, Tobin, Nicole H., additional, Toltzis, Philip, additional, Treat, James, additional, Troy, Stephanie B., additional, Van, Russell B., additional, Vaz, Louise Elaine, additional, Vodzak, Jennifer, additional, Wald, Ellen R., additional, Wallihan, Rebecca, additional, Wangu, Zoon, additional, Washam, Matthew, additional, Watson, Joshua R., additional, Wattier, Rachel L., additional, Weinberg, Geoffrey A., additional, White, A. Clinton, additional, Wiesenfeld, Harold C., additional, Williams, John V., additional, Willoughby, Rodney E., additional, Wingerter, Sarah L., additional, Wittler, Robert R., additional, Wong, Karen K., additional, Workowski, Kimberly A., additional, Wright, Terry W., additional, Yagupsky, Pablo, additional, Yen, Catherine, additional, Yi, Jumi, additional, Yoder, Jonathan S., additional, Young, Edward J., additional, Zaenglein, Andrea L., additional, and Zimmerman, Kanecia, additional

Published
2018
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36. Dual latent tuberculosis screening with tuberculin skin tests and QuantiFERON-TB assays before TNF-α inhibitor initiation in children in Spain

Author

Calzada-Hernández, Joan, primary, Anton, Jordi, additional, Martín de Carpi, Javier, additional, López-Montesinos, Berta, additional, Calvo, Inmaculada, additional, Donat, Ester, additional, Núñez, Esmeralda, additional, Blasco Alonso, Javier, additional, Mellado, María José, additional, Baquero-Artigao, Fernando, additional, Leis, Rosaura, additional, Vegas-Álvarez, Ana María, additional, Medrano San Ildefonso, Marta, additional, Pinedo-Gago, María del Carmen, additional, Eizaguirre, Francisco Javier, additional, Tagarro, Alfredo, additional, Camacho-Lovillo, Marisol, additional, Pérez-Gorricho, Beatriz, additional, Gavilán-Martín, César, additional, Guillén, Sara, additional, Sevilla-Pérez, Belén, additional, Peña-Quintana, Luis, additional, Mesa-Del-Castillo, Pablo, additional, Fortuny, Clàudia, additional, Tebruegge, Marc, additional, and Noguera-Julian, Antoni, additional

Published
2022
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37. Performance of QuantiFERON-TB Gold Plus assays in paediatric tuberculosis: a multicentre PTBNET study

Author

Buonsenso, Danilo, primary, Noguera-Julian, Antoni, additional, Moroni, Rossana, additional, Hernández-Bartolomé, Angel, additional, Fritschi, Nora, additional, Lancella, Laura, additional, Cursi, Laura, additional, Soler-Garcia, Aleix, additional, Krüger, Renate, additional, Feiterna-Sperling, Cornelia, additional, Sali, Michela, additional, Lo Vecchio, Andrea, additional, Scarano, Sara, additional, Hernanz Lobo, Alicia, additional, Espiau, Maria, additional, Soriano-Arandes, Antonio, additional, Cetin, Benhur Sirvan, additional, Brinkmann, Folke, additional, Ozere, Iveta, additional, Baquero-Artigao, Fernando, additional, Tsolia, Maria, additional, Milheiro Silva, Tiago, additional, Bustillo-Alonso, Matilde, additional, Martín Nalda, Andrea, additional, Mancini, Margherita, additional, Starshinova, Anna, additional, Ritz, Nicole, additional, Velizarova, Svetlana, additional, Ferreras-Antolín, Laura, additional, Götzinger, Florian, additional, Bilogortseva, Olga, additional, Chechenyeva, Vira, additional, Tebruegge, Marc, additional, and Santiago-García, Begoña, additional

Published
2022
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38. Accuracy of Xpert Ultra for the diagnosis of paediatric tuberculosis in a low TB burden country: a prospective multicentre study

Author

Aguilera-Alonso, David, primary, Solís-García, Gonzalo, additional, Noguera-Julian, Antoni, additional, González-Martín, Julián, additional, Román Cobeña, Angely, additional, Baquero-Artigao, Fernando, additional, Toro Rueda, Carlos, additional, Rodríguez-Molino, Paula, additional, Bloise Sánchez, Iván, additional, Vallmanya, Teresa, additional, Bernet-Sánchez, Albert, additional, Minguell Domingo, Laura, additional, Rubio, Adriana, additional, Saavedra-Lozano, Jesús, additional, Ruiz-Serrano, María Jesús, additional, Blázquez-Gamero, Daniel, additional, López-Roa, Paula, additional, Gomez-Pastrana, David, additional, López Prieto, María Dolores, additional, López Medina, Eva María, additional, Gil-Brusola, Ana, additional, Martín Nalda, Andrea, additional, Soriano-Arandes, Antonio, additional, Tórtola, Teresa, additional, Falcon-Neyra, Lola, additional, González Galán, Verónica, additional, Tebruegge, Marc, additional, and Santiago-García, Begoña, additional

Published
2022
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42. Mycobacterium ulcerans-specific immune response after immunisation with bacillus Calmette-Guérin (BCG) vaccine

Author

Pittet, Laure, Tebruegge, Marc, Dutta, Binita, Donath, Susan, Messina, Nicole, Casalaz, Dan, Hanekom, Willem A, Britton, Warwick J, Robins-Browne, Roy, Curtis, Nigel, Ritz, Nicole, and BCG Immune Response Study (BIRS) group

Subjects
Buruli ulcer, medicine.medical_treatment, 030231 tropical medicine, complex mixtures, Russia, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Immune system, Japan, Humans, Medicine, 030212 general & internal medicine, Mycolactone, Randomised controlled trial, Mycobacterium bovis, ddc:618, Mycobacterium ulcerans, General Veterinary, General Immunology and Microbiology, biology, business.industry, Prevention, Australia, Immunity, Public Health, Environmental and Occupational Health, Infant, biology.organism_classification, Acquired immune system, medicine.disease, 3. Good health, Infectious Diseases, Cytokine, chemistry, Immunology, BCG Vaccine, Molecular Medicine, Immunization, business, Cross-protection, BCG vaccine
Abstract

Background Bacillus Calmette–Guerin (BCG) vaccine provides partial protection against Buruli ulcer caused by Mycobacterium ulcerans in epidemiological studies. This study aimed to quantify M. ulcerans-specific immune responses induced by BCG immunisation. Methods Intracellular cytokine analysis of in-vitro experiments done 10 weeks after BCG immunisation in 130 Australian infants randomised to one of three BCG vaccine strains given either at birth (BCG-Denmark, BCG-Japan, or BCG-Russia) or at two months of age (BCG-Denmark). Results Proportions of polyfunctional CD4+ T-cells were higher in M. ulcerans-stimulated compared to unstimulated control samples. These proportions were not influenced by the vaccine strain or timing of the immunisation. The M. ulcerans-specific immune responses showed similar patterns to those observed in M. tuberculosis-stimulated samples, although they were of lower magnitude. Conclusions Our data show that BCG immunisation induces M. ulcerans-specific immune responses in infants, likely explaining the cross-protective effect observed in epidemiological studies. (ACTRN12608000227392)

Published
2021

43. Accuracy of Xpert Ultra for the diagnosis of paediatric tuberculosis in a low TB burden country: a prospective multicentre study

Author

Ministerio de Sanidad (España), Instituto de Salud Carlos III, European Commission, Generalitat de Catalunya, Ministerio de Ciencia e Innovación (España), Aguilera-Alonso, David, Solís-García, Gonzalo, Noguera-Julián, Antoni, González-Martín, Julián, Román Cobeña, Angely, Baquero-Artigao, Fernando, Toro Rueda, Carlos, Rodríguez-Molino, Paula, Bloise Sánchez, Iván, Vallmanya, Teresa, Bernet-Sánchez, Albert, Minguell Domingo, Laura, Rubio, Adriana, Saavedra-Lozano, Jesús, Ruiz-Serrano, María Jesús, Blázquez-Gamero, Daniel, López-Roa, Paula, Gómez-Pastrana, David, López Prieto, María Dolores, López Medina, Eva María, Gil-Brusola, Ana, Martín Nalda, Andrea, Soriano-Arandes, Antoni, Tórtola, Teresa, Falcón Neyra, Lola, González Galán, Verónica, Tebruegge, Marc, Santiago-García, Begoña, Ministerio de Sanidad (España), Instituto de Salud Carlos III, European Commission, Generalitat de Catalunya, Ministerio de Ciencia e Innovación (España), Aguilera-Alonso, David, Solís-García, Gonzalo, Noguera-Julián, Antoni, González-Martín, Julián, Román Cobeña, Angely, Baquero-Artigao, Fernando, Toro Rueda, Carlos, Rodríguez-Molino, Paula, Bloise Sánchez, Iván, Vallmanya, Teresa, Bernet-Sánchez, Albert, Minguell Domingo, Laura, Rubio, Adriana, Saavedra-Lozano, Jesús, Ruiz-Serrano, María Jesús, Blázquez-Gamero, Daniel, López-Roa, Paula, Gómez-Pastrana, David, López Prieto, María Dolores, López Medina, Eva María, Gil-Brusola, Ana, Martín Nalda, Andrea, Soriano-Arandes, Antoni, Tórtola, Teresa, Falcón Neyra, Lola, González Galán, Verónica, Tebruegge, Marc, and Santiago-García, Begoña

Abstract

[Introduction] Childhood pulmonary tuberculosis (TB) remains a diagnostic challenge. This study aimed to evaluate the performance of Xpert Ultra for the diagnosis of pulmonary TB in children in a low TB prevalence setting., [Methods] Prospective, multicentre, diagnostic accuracy study. Children with clinical or radiological suspicion of pulmonary TB were recruited at 11 paediatric units in Spain. Up to three gastric or sputum specimens were taken on 3 consecutive days, and analysed by Xpert MTB/RIF, Xpert Ultra and culture in parallel., [Results] 86 children were included (median age 4.9 years, IQR 2.0–10.0; 51.2% male). The final diagnosis was pulmonary TB in 75 patients (87.2%); 33 (44.0%) were microbiologically confirmed. A total of 219 specimens, comprising gastric aspirates (n=194; 88.6%) and sputum specimens (n=25; 11.4%), were analysed. Using culture as reference standard and comparing individual specimens, the sensitivity was 37.8% (14/37) for Xpert MTB/RIF and 81.1% (30/37) for Xpert Ultra (p<0.001); specificity was 98.4% (179/182) and 93.4% (170/182), respectively (p=0.02). In the per-patient analysis, considering positive results on any specimen, the sensitivity was 42.9% (9/21) for Xpert MTB/RIF and 81.0% for Xpert Ultra (17/21, p=0.01); specificity was 96.9% (63/65) and 87.7% (57/65, p=0.07), respectively., [Conclusions] In children with pulmonary TB in a low burden setting, Xpert Ultra has significantly higher sensitivity than the previous generation of Xpert assay and only marginally lower specificity. Therefore, in children undergoing evaluation for suspected pulmonary TB, Xpert Ultra should be used in preference to Xpert MTB/RIF whenever possible.

Published
2022

44. Treatment and outcome in children with tuberculous meningitis: A multicenter pediatric tuberculosis network european trials group study

Author

Deutsche Gesellschaft für Internationale Zusammenarbeit, National Institute for Health Research (UK), London School of Economics and Political Science, Generalitat de Catalunya, Junta de Andalucía, Thee, Stephanie [0000-0001-9090-7869], Buonsenso, Danilo [0000-0001-8567-2639], Thee, Stephanie, Basu Roy, Robindra, Blázquez-Gamero, Daniel, Falcón Neyra, Lola, Neth, Olaf, Noguera-Julián, Antoni, Lillo, Cristina, Galli, Luisa, Venturini, Elisabetta, Buonsenso, Danilo, Götzinger, Florian, Martinez-Alier, Nuria, Velizarova, Svetlana, Brinkmann, Folke, Welch, Steven B., Tsolia, Maria, Santiago-García, Begoña, Schilling, Ralph, Tebruegge, Marc, Krüger, Renate, Deutsche Gesellschaft für Internationale Zusammenarbeit, National Institute for Health Research (UK), London School of Economics and Political Science, Generalitat de Catalunya, Junta de Andalucía, Thee, Stephanie [0000-0001-9090-7869], Buonsenso, Danilo [0000-0001-8567-2639], Thee, Stephanie, Basu Roy, Robindra, Blázquez-Gamero, Daniel, Falcón Neyra, Lola, Neth, Olaf, Noguera-Julián, Antoni, Lillo, Cristina, Galli, Luisa, Venturini, Elisabetta, Buonsenso, Danilo, Götzinger, Florian, Martinez-Alier, Nuria, Velizarova, Svetlana, Brinkmann, Folke, Welch, Steven B., Tsolia, Maria, Santiago-García, Begoña, Schilling, Ralph, Tebruegge, Marc, and Krüger, Renate

Abstract

[Background]: Currently, data on treatment, outcome, and prognostic factors in children with tuberculous meningitis (TBM) in Europe are limited. To date, most existing data on TBM originate from adult studies, or studies conducted in low-resource settings., [Methods]: We designed a multicenter, retrospective study involving 27 pediatric healthcare institutions in 9 European countries via an established pediatric TB research network, before and after the 2014 revision of World Health Organization (WHO) dosing recommendations., [Results]: Of 118 children, 39 (33.1%) had TBM grade 1, 68 (57.6%) grade 2, and 11 (9.3%) grade 3. Fifty-eight (49.1%) children received a standard 4-drug treatment regimen; other commonly used drugs included streptomycin, prothionamide, and amikacin. Almost half of the patients (48.3%; 56/116) were admitted to intensive care unit, with a median stay of 10 (interquartile range [IQR] 4.5–21.0) days. Of 104 children with complete outcome data, 9.6% (10/104) died, and only 47.1% (49/104) recovered fully. Main long-term sequelae included spasticity of 1 or more limbs and developmental delay both in 19.2% (20/104), and seizure disorder in 17.3% (18/104). Multivariate regression analyses identified microbiological confirmation of TBM, the need for neurosurgical intervention, and mechanical ventilation as risk factors for unfavorable outcome., [Conclusions]: There was considerable heterogeneity in the use of TB drugs in this cohort. Despite few children presenting with advanced disease and the study being conducted in a high-resource setting, morbidity and mortality were high. Several risk factors for poor outcome were identified, which may aid prognostic predictions in children with TBM in the future.

Published
2022

46. Bacillus Calmette-Guérin Skin Reaction Predicts Enhanced Mycobacteria-Specific T-Cell Responses in Infants: APost HocAnalysis of a Randomized Controlled Trial

Author

Pittet, Laure F., primary, Fritschi, Nora, additional, Tebruegge, Marc, additional, Dutta, Binita, additional, Donath, Susan, additional, Messina, Nicole L., additional, Casalaz, Dan, additional, Hanekom, Willem A., additional, Britton, Warwick J., additional, Robins-Browne, Roy, additional, Curtis, Nigel, additional, and Ritz, Nicole, additional

Published
2022
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48. Performance of QuantiFERON-TB Gold Plus assays in children and adolescents at risk of tuberculosis: a cross-sectional multicentre study

Author

Soler-Garcia, Aleix, primary, Gamell, Anna, additional, Pérez-Porcuna, Tomàs, additional, Soriano-Arandes, Antonio, additional, Santiago, Begoña, additional, Tórtola, Teresa, additional, Ruiz-Serrano, María Jesús, additional, Korta Murua, José Javier, additional, Bustillo-Alonso, Matilde, additional, Garrote-Llanos, María Isabel, additional, Rodríguez-Molino, Paula, additional, Piqueras, Ana Isabel, additional, Tagarro, Alfredo, additional, Monsonís, Manuel, additional, Tebruegge, Marc, additional, and Noguera-Julian, Antoni, additional

Published
2021
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49. Performance of QuantiFERON- Gold Plus assays in children and adolescents at risk of tuberculosis: a cross-sectional multicentre study.

Author

Soler-Garcia, Aleix, Gamell, Anna, Pérez-Porcuna, Tomàs, Soriano-Arandes, Antonio, Santiago, Begoña, Tórtola, Teresa, Jesús Ruiz-Serrano, María, Korta Murua, José Javier, Bustillo-Alonso, Matilde, Isabel Garrote-Llanos, María, Rodríguez-Molino, Paula, Isabel Piqueras, Ana, Tagarro, Alfredo, Monsonís, Manuel, Tebruegge, Marc, Noguera-Julian, Antoni, Ruiz-Serrano, María Jesús, Garrote-Llanos, María Isabel, Piqueras, Ana Isabel, and QFT-Plus Study Group of the Spanish Pediatric TB Research Network

Subjects
LATENT tuberculosis, LYMPHADENITIS, TUBERCULOSIS, NEUROBLASTOMA, MYCOBACTERIAL diseases, LATENT infection, TEENAGERS, TUBERCULOSIS diagnosis, CROSS-sectional method, INTERFERON gamma release tests, EVALUATION research, TUBERCULIN test, RESEARCH, COMPARATIVE studies, MYCOBACTERIUM tuberculosis
Abstract

Introduction: The QuantiFERON-TB Gold Plus (QFT-Plus) assay, which features two antigen-stimulated tubes (TB1 and TB2) instead of a single tube used in previous-generation interferon-gamma release assays (IGRAs), was launched in 2016. Despite this, data regarding the assay's performance in the paediatric setting remain scarce. This study aimed to determine the performance of QFT-Plus in a large cohort of children and adolescents at risk of tuberculosis (TB) in a low-burden setting.Methods: Cross-sectional, multicentre study at healthcare institutions participating in the Spanish Paediatric TB Research Network, including patients <18 years who had a QFT-Plus performed between September 2016 and June 2020.Results: Of 1726 patients (52.8% male, median age: 8.4 years), 260 (15.1%) underwent testing during contact tracing, 288 (16.7%) on clinical/radiological suspicion of tuberculosis disease (TBD), 649 (37.6%) during new-entrant migrant screening and 529 (30.6%) prior to initiation of immunosuppressive treatment. Overall, the sensitivity of QFT-Plus for TBD (n=189) and for latent tuberculosis infection (LTBI, n=195) was 83.6% and 68.2%, respectively. The agreement between QFT-Plus TB1 and TB2 antigen tubes was excellent (98.9%, κ=0.961). Only five (2.5%) patients with TBD had discordance between TB1 and TB2 results (TB1+/TB2-, n=2; TB1-/TB2+, n=3). Indeterminate assay results (n=54, 3.1%) were associated with young age, lymphopenia and elevated C reactive protein concentrations.Conclusions: Our non-comparative study indicates that QFT-Plus does not have greater sensitivity than previous-generation IGRAs in children in both TBD and LTBI. In TBD, the addition of the second antigen tube, TB2, does not enhance the assay's performance substantially. [ABSTRACT FROM AUTHOR]

Published
2022
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