Search

Your search keyword '"Tebib, Jacques"' showing total 292 results
Start Over Author "Tebib, Jacques"
292 results on '"Tebib, Jacques"'

6. Clinical features and prognostic factors of listeriosis: the MONALISA national prospective cohort study

Author

Hausfater, Pierre, Pourriat, Jean-Louis, Casalino, Enrique, Riou, Bruno, Pateron, Dominique, Yéni, Patrick, Bricaire, François, Ville, Yves, Azria, Elie, Dommergues, Marc, Bergmann, Jean-François, Wolff, Michel, Mira, Jean-Paul, Guillevin, Loïc, Zuber, Mathieu, Abasse, Soumeth, Aberrane, Saïd, Abgueguen, Pierre, Abokasem, Ayman, Abraham, Bruno, Ache-Papillon, Chantal, Adam, Pascal, Adam, Marie-Noëlle, Adhoute, Xavier, Adoue, Daniel, Afi, Moncef, Afroukh, Nawel, Agha-Mir, Ilhem, Aissa, Nejla, Aissaoui, Liamine, Akerman, Grégory, Akkari, Ali, Al Chaar, Majed, Al Freijat, Faraj, Al-Jalaby, Bachar, Albert, Didier, Albertini, Marie-Thérèse, Albinet, Hélène, Alfonsi, Gwenaël, Ali, Youssef, Chaouche, Zahr-Eddine Ali, Allart, Anne, Alric, Laurent, Améri, Alain, Amoura, Zahir, Ampère, Alexandre, Amroun, Hakim, Ananivi, Amévi, Ancelin, Pascal, André, Thierry, Andremont, Antoine, Andreotti, Dominique, Andriamaneo, Hélinoro, Andriau, Clara, Anglaret, Hélène, Anguel, Nadia, Annaix, Véronique, Anteur, Wassila, Anuset, Delphine, Aoudia, Ourida, Arabi, Miloud, Archambaud, Muriel, Archambaud, Maryse, Ardiet, Emmanuel, Argaud, Laurent, Arista, Sophie, Arlet, Guillaume, Armengaud, Jean, Arnal, Jean-Michel, Arnault, Isabelle, Arsène, Olivier, Assaf, Ziad, Assi, Assi, Assouline, David, Astruc, Dominique, Aubard, Yves, Aubert, Claude, Aubry, Jean-Paul, Auburtin, Marc, Aucher, Philippe, Audeguy, Philippe, Audié, Jean-Pierre, Aumaitre, Hugues, Aumersier, Michel, Auroux, Jean, Autret, Fanny, Auvray, Etienne, Ayach, Badih, Aye, Paul, Ayouz, Khélifa, Bachelier, Marie-Nadège, Badia, Thomas Bachelot Philippe, Badila, Patrice, Bador, Julien, Badurescu, Viorica, Baldesi, Olivier, Bandaly, Françoise, Bandin, Olivia, Bani-Sadr, Firouzé, Bannier, Stéphanie, Baranger, Thierry, Barazer, Isabelle, Barbier, Marie-Christine, Barbier, François, Barbier, Carole, Barbieux, Marianne, Marie, Barboteau, Annick, Barbut, Patricia, Baret, Mylène, Barière, François, Baril, Jean-Yves, Barillot, Isabelle, Barjon, Geneviève, Barnaud, Guilène, Barraduc, Régine, Barraud, Francis, Barraud, Olivier, Barre, Eric, Barrelet, Audrey, Barrier, Jocelyn, Bart, Fréderic, Barthélémy, Gérard, Baty, Gaëlle, Baud, Olivier, Baudel, Jean-Luc, Bay, Jacques-Olivier, Bay, Jérôme, Bazin, Claude, Beague, Sébastien, Beal Ardisson, Dominique, Beaune, Bertrand, Beauplet-Lepage, Anne, Bébéar, Cécile, Bechade, Dominique, Becherrawy, Céline, Becker-Schneider, Michelle, Bednarek, Nathalie, Bedock, Bernard, Begon, Edouard, Bekguesmia, Zaineb, Belaisch-Amart, Joëlle, Belhadj, Karim, Belle, Evelyne, Belmonte, Olivier, Belot, Jean-Pierre, Bemrah, Abdelkader, Ben Soltana, Mouna, Benbara, Amélie, Benddif-Fin, Faiza, Bénézit, François, Benifla, Jean-Louis, Benjelloul, Amine, Benkaci, Yacine, Benkhelil, Abdelaziz, Benoit-Cattin, Thierry, Benoit-Coustou, Sophie, Bensadoun, René-Jean, Bensaid, Thierry, Jacques Bensaude, Raoul, Bérard, Henri, Bercot, Béatrice, Berdin, Bruno, Berger, Marc, Berger, Pierre, Bergheul, Smail, Bergues, Benoît, Berland, Yvon, Bernard, Claude, Bernard, Louis, Bernardaud, Bérangère, Bernardi, Franck, Bernardin, Gilles, Bernasconi, François, Bert-Marcaz, Patrick, Berteaux, Béatrice, Berth-Farges, Anne, Berthelot, Gilles, Berthet, Jean, Bertrand, Kevin, Bertrou, Anne, Besnard, Marianne, Bessede, Emilie, Bethery, Philippe, Beuscart, Claude, Beyne-Rauzy, Odile, Beytout, Jean, Bezian, Marie-Christine, Bicais, Brigitte, Bidart, Sabine, Bidault, Christian, Biessy, Hélène, Bigot, Pierre, Bildea, Adrianna, Bille, Emmanuelle, Billy, Christophe, Biron, Nathalie, Bizet, Jérôme, Blaise, Didier, Blaise, Agathe, Blaison, Gilles, Blaka, Mariam, Blanc, Pierre, Blanc, Stéphane, Blanc-Amrane, Véronique, Blanchard, Pierre, Blanchard-Marche, Geneviève, Blancs, Michèle, Blazejewski, Caroline, Bléher, Yves, Blewoussi, Koffi, Blondet, Romain, Blot, François, Blum, Georges-Fabrice, Bodson, Lucien, Boidin, Emilie, Boileau, Julien, Boileau, Pascal, Boin-Gay, Véronique, Boisseau, Martial, Boisselier, Christine, Bollaert, Pierre-Edouard, Bolot, Pascal, Bonacorsi, Stéphane, Bonfils, Marie, Bonitchi, Pascal, Bonnan, Mickael, Bonnefoy, Philippe, Bonnet, Delphine, Bonnet, Richard, Bonnin, Emmanuelle, Bor, Jacques, Borie, Marie-Françoise, Borstein, Bernard, Bossi, Philippe, Botreau, Yves, Bottero, Julie, Bouasria, Abderrezak, Bouaziz, Radia, Bouchaud, Olivier, Bouche, Flore, Bouchet, Gérard, Bouden, Vincent, Boudhane, Amar, Boudy, Carole-Anne, Boue, François, Bouet, Cédric, Claude Boufetteau, Jean, Bouffandeau, Bernard, Bouhour, Damien, Bouiller, Marc, Bouillet, Laurence, Bouissou, Antoine, Boulain, Luc, Bourgeois, Stéphane, Bourgerette, Evelyne, Bourlet, Anne, Bourlière, Marc, Bourrée, Thomas, Bourrouillou, Aude, Boussekey, Nicolas, Boussier, Remi, Boutoille, David, Bouyer, Jean-Luc, Bouyssou-Destriau, Denise, Bouziges, Nicole, Boyer, Michelle, Braem, Louis, Branger, Bernard, Branger, Catherine, Brasme, Lucien, Bray, Philippe, Brazille, Patricia, Bresson, Violaine, Bret, Laurent, Breton, Anne-Laure, Breuil, Jacques, Brevet, Françoise, Briaud, Michel, Bridoux, Delphine, Briend, Delphine, Briere, Anne-Isabelle, de la Hosseraye, Claire Briere, Brieu, Nathalie, Brieux, Jean-Philippe, Brihier, Hélène, Brisou, Patrick, Brival, Marie-Laure, Broche, David, Brochen, Joëlle, Bron, Camille, Bronet, Nathalie, Bronner, Jacques, Bronowicki, Jean-Pierre, Brosset, François, Brottier-Mancini, Elisabeth, Brovedani, Sophie, Bruley des Varannes, Stanislas, Brunel, Pascale, Brunet, Patrick, Brunet, Xavier, Brunet, Stéphanie, Brung-Lefebvre, Maud, Brunot, Vincent, Brusset, Alain, Burc-Struxiano, Laurence, Burdin, Michèle, Bureau, Thierry, Buron, Fanny, Burucoa, Christophe, Cabalion, Jean, Cabasson, Severine, Cabié, André, Cacheux, Victoria, Cadiergue, Vincent, Cadiot, Guillaume, Caille, Vincent, Cailleaux Pierre-Etienne Cailleux, Vincent, Caillon, Jocelyne, Caillot, Denis, Camara, Mohamed, Cambau, Emmanuelle, Cambonie, Gilles, Camiade, Sabine, Canis, Frederique, Canitrot, Meriem, Canu, Nathalie, Capellier, Gilles, Carbillon, Lionel, Carbonelle, Bernard, Carbonelle, Etienne, Carboni, Marion, Carbonne, Bruno, Carcenac, Francis, Cardot, Florence, Carette, Sylvie, Cariou, Sylvie, Carli, Pierre, Carmagnol, Françoise, Caroli-Bosc, François-Xavier, Caron, François, Cartron, Guillaume, Casali, Patrick, Casanovas, Olivier, Cassignard, Dominique, Castaing, Denis, Castel, Brisse, Castelin, Sandrine, Castelnau, Pierre, Cathebras, Pascal, Catineau, Jean, Catteu, Sylviane, Cattier, Blandine, Cattoen, Christian, Cattoir, Vincent, Caumes, Eric, Caussin, Jean, Cavalié, François, Ceppa, Franck, Cerf, Charles, Ceriez, Anne, Cervantes, Nathalie, Chabanon-Pouget, Bruno, Chabrol, Amélie, Chachaty, Elisabeth, Chahtour, Hanen, Chaix, Fabrice, Challier, Marion, Chalvon-Demersay, Arnaud, Chambreuil, Guy, Chaminade, Bruno, Chamouine, Abdourahim, Chandesris Joséphine Chapalain-Cagnon, Christine, Chapelle, Alain, Chaplain, Chantal, Chapuzet, Claire, Charachon, Sylvie, Charasse, Christophe, Charbonnier, Thierry, Charlier, Franck, Chassin, Olivier, Chassy, Véronique, Chatellier, Delphine, Chatron, Marlène, Chaussade, Hélène, Chavanet, Pascal, Chavel, Pascale, Chekroun, Ali, Chelle, Wladimir, Chelly, Jonathan, Cherlet, Christel, Chevailler, Alain, Chevalet, Pascal, Chevalier, Yannick, Chidiac, Christian, Chimot, Loïc, Chiouk, Nabil, Chiron, Philippe, Chirouze, Catherine, Chopin, Marie-Charlotte, Choukroun, Gabriel, Chouraqui, Martine, Chraibi, Kamilla, Chudersky, Dominique, Chuzeville, Michel, Cingotti, Michel, Cinquetti, Gael, Ciocan, Dragos, Citony, Isabelle, Claise, Catherine, Clarissou-Philippe, Juliette, Claude, Benoît, Clave, Danielle, Clément, Christophe, Climas, Marie-Thérèse, Coetmeur, Daniel, Cognet, Stéphanie, Cohen, Daniel, Coignard, Sophie, Coindre, Jean-Philippe, Coint, Raphaël, Colamarino, Renato, Colingorski, Anne-Marie, Collard, Olivier, Collet, Michel, Collignon, Anne, Collus, Marie-José, Colombani, Jean-Claude, Colombat, Philippe, Combe, Christian, Condominas, Philippe, Conroy, Marie-Chrsitine, Constans, Thierry, Constantin, Nicole, Contamin, Claudine, Corberand, Damien, Cordier, Anne-Marie, Cordonnier, Charlotte, Corneloup, Hélène, Costa, Yannick, Costa, Frédérique, Coste, Mathieu, Costes, Corinne, Cotes, Françoise, Cotteret, Rabea, Couderc, Louis-Jean, Cougoul, Pierre, Coulaud, Jean-Michel, Coulhon, Marie-Pierre, Coulon, Patrice, Courcol, René, Courillon, Florence, Courjon, Johan, Courouble, Jérémie, Courouge-Dorcier, Dominique, Courtade, Henri, Courtois, Stéphanie, Couturier, Pascal, Créange, Alain, Cremet, Lise, Cremniter, Julie, Croize, Jacques, Crombe, Valérie, Croquet, Ingrid, Cua, Eric, Cufi, Marie-Noelle, Cuvillier, Patrice, Dabysing, Marie-Françoise, Dadoun, Karim, Dagada, Corinne, Dahan, Sonia, Dahoumane, Redouane, Daleas, Jacques, Dallay, Dominique, Dalle, Benoît, Damage, Alexandre, Damaj, Lena, Damaj Gandhi, Laurent, Danalaché, Ana, Danin, Pierre-Eric, Danjean, Marie-Pierre, Danquechin Dorval, Etienne, Dao, Anne, Daoud, Patrick, Darchen, Olivier, Dargère, Sylvie, Darre, Bincy, Dassant, Damien, Dassieu, Gilles, Dattin-Dorrière, Valérie, Daupin, Cedric, Daurel, Claire, Dausset, Jean-Claude, Daval Cote, Mélanie, David, Gary, Davido, Benjamin, De Barbeyrac, Bertille, De Biasi, Michel, De Boysson, Hubert, De Clareuil, Edith, De Kermadec, Jean-Michel, De Martino, Sylvie, De Tayrac, Renaud, De Varax, Roland, De Witte, Sten, Debernardi, Anne, Deboutin, Jean-Luc, Debouverie, Marc, Decoene, Christophe, Decoster, Anne, Decousser, Jean-Winoc, Decré, Dominique, Defebvre, Renaud, Degand, Nicolas, Degreff, Jean-Marc, Deiber, Michel, Delaby, Hélène, Delacour, Thierry, Delahaye, Arnaud, Delarbre, Jean-Marie, Delasalle, Chantal, Delbrouck, Claire, Delecalle, Jean-Gilles, Delesalle, Sophie, Delesalle, Chantal, Delhoustal, Laurence, Deligne, Delphine, Delisle Mizon, Françoise, Delobel, Pierre, Delour, Pierre, Delpeuch, Bruno, Demachy, Marie-Claude, Demarchi, Martin, Demarcq, Marie-Joelle, Demontclos, Henri, Dengo, Jean-Christophe, Deprecq, Sophie, Dequin, Pierre-François, Dereeper, Olivier, Deroux, Alban, Derragui, Aicha, Desblache, Julien, Desbois-Nogard, Nicole, Descamps, Dominique, Descamps, Jean-Michel, Deschamps, Christophe, Deschamps, Jacques, Desemerie, Franck, Desfrere, Luc, Desliers, Joelle, Desnoulez, Laurence, Desplaces, Nicole, Després, Nicolas, Dessin, Jean-François, Destors, Marie, Detante, Olivier, Detave, Mathieu, Detourmignies, Laurence, Devaud, Edouard, Devaux, Yves, Devaux, Bruno, Devianne, François, Devidas, Alain, Devos, Philippe, Dewitte, Camille, Dewulf, Gisèle, Dhennain, Chantal, Di Meglio, Chloé, Diallo, Habiboulaye, Diamantis, Sylvain, Dib, Baihas, Didier, Jean-Marc, Dillies, Anne-Françoise, Dingremont, Claire, Djafari, Noureddine, Djeffal, Abdelmajid, Djerad, Hama, Dollon, Christophe, Doloy, Alexandra, Domart, Yves, Donay, Jean-Luc, Dopeux, Loïc, Dorr, Gaelle, Doucet Populaire, Florence, Dournon, Nathalie, Dreyfus, Michel, Dreyfuss, Didier, Du Cheyron, Damien, Dubois, Elodie, Dubois, Nicolas, Dubosc-Marchenay, Nadine, Dubourdieu, Béatrice, Dubroca, Nadine, Dubus, Jean-Christophe, Duche, Catherine, Duchene, Francis, Dudeffant, Patrick, Duez, Jean-Marie, Duhaut, Pierre, Duluc, Françoise, Dumouchel, Hélène, Dumoulard, Bruno, Dupin, Clarisse, Dupon, Michel, Dupont, Mathieu, Dupont, Damien, Dupont, Patrick, Dupre-Narlet, Emmanuelle, Dupretz, Peggy, Dupuy, Claire-Antoinette, Durand, Michel, Durand, Annie, Durliat-Ellie, Solène, Durox, Hélène, Dussopt, Christine, Dutasta, Fabien, Duval, Véronique, Dzeing, Ella, Eboue, Florence, Ede, Cyrille, Eid, Hanna, El Yamani, Abderrazak, Elbez, Annie, Eldeghedy, Mohamed, Elena-Daumas, Martine, Elhadad, Simon, Elharie-Heraux, Zoubida, Eloy, Clarence, Emeriau, Marie-Etiennette, Emond, Jean-Philippe, Equy, Véronique, Erena-Penet, Anne-Sophie, Esnault, Cecilia, Esposito, Laure, Essouri, Sandrine, Estépa, Laurence, Estève, Vincent, Etchemendy, Sabine, Ettahar, Nicolas, Eustache, Marie-Line, Evillard, Mathieu, Evreux, Françoise, Eychene, Jean-Marc, Eyer, Didier, Eymerit, Philippe, Fabre, Jean-Luc, Fabre, Claire, Faibis, Frédéric, Falchero, Lionel, Falguières, Odile, Fallouh, Hassan, Fanjaud, Nicolas, Fantin, Bruno, Farah, Ibrahim, Farto-Bensasson, Fernanda, Fauchais, Anne-Laure, Fauchart, Jean-Pierre, Faucher, Anna, Faucheux, Jean-Marc, Faudon-Gibelin, Anne, Faurie, Pierre, Fèbre, Claudine, Feddal, Toufik, Ferhat Carre, Assia, Ferreira-Maident, Nicole, Ferreyra, Milagros, Ferroni, Agnès, Ferry, Tristan, Feugier, Pierre, Feugier, Jean-Claude, Fezoui, Hacene, Fiette, Hélène, Fille, Alexandra, Filloux, Jean-Michel, Fily, Fabien, Fines, Marguerite, Fissore Magdelein, Cristel, Flahault, Mathilde, Floriot, Christian, Foguem, Clovis, Fonsale, Nathalie, Fontenel, Benoît, Forest, Anne-Marie, Forest, Anne, Forestier, Emmanuel, Fortin, Louise, Fortineau, Nicolas, Fos, Marie-Pierre, Foucart, Saskia, Fouilhoux, Alain-Charles, Fournel, Pierre, Fournier, Damien, Fourrier, François, Fraisse, Thibaut, Fredenucci, Isabelle, Fremin-Batteux, Odile, Frey, Janine, Frimat, Luc, Froidure, Marie, Fruchart, Christophe, Fruleux, Nathalie, Fuhrmann, Christine, Fuillet, Michel, Funakoshi, Nathalie, Fur, Alain, Gabez-Therou, Patricia, Gaborieau, Valerie, Gabriel-Soléan, Sylvie, Gachassin, Laurence, Gaide, Jean-François, Gaillard, Julia, Gaillard, Jean-Louis, Gaillart, Tiphaine, Gaizi, Sad, Gallo, Nicolas, Gameiro, Manuel-Luis, Garandeau, Caroline, Garbi, Aurelie, Garcera, Yves, Gardes, Ghislaine, Garesslin, Olivier, Garnier, Fabien, Garofano, Marie, Garosi, Olivier, Garre, Michel, Garrec, Hélène, Garrigues, Bernard, Gaschet, Anne, Gascon, Alexandre, Gascou, Emmanuel, Gasnault, Jacques, Gatfosse, Marc, Gattault, Jean-François, Gatti, Hélène, Gauche, Bernard, Gaudard, Philippe, Gaudelus, Joel, Gaudry, Stéphane, Gauduchon, Valérie, Gaulthier, Jean-Baptiste, Gauthier, Yvan, Gebeile, Rémi, Geffray, Loïc, Geffroy, Françoise, Geissler, Alain, Gelez, Maud, Gendrin, Vincent, Gengembre, Guy, Gentilhomme, Hervé, Gérart Pons, Sandrine, Germain, Marie-Claude, Gesquière, Julien, Ghedira, Adel, Ghevaert, Christine, Gillot, Jean-Michel, Girard, Edouard, Girard, Serge, Girard, Pierre-Marie, Girard-Buttaz, Isabelle, Giraud, Martine, Glorieux, Isabelle, Goburdhun, Chandrah, Godin, Michel, Godon, Catherine, Goehringer, François, Goffart, Sylvie, Goidin, Isabelle, Goldgran Toledano, Daniele, Golfier, François, Goll, Armand, Gontieron, Olivier, Goquelin, Anne, Got, Laurence, Goudeau, Alain, Goujard, Cécile, Goupil, François, Gouraud, François, Gourlaouen, Alain, Gournay, Jérôme, Goustille, Julien, Goux, Alain, Grandclerc, Benoît, Grange, Jean-Didier, Granger, Thierry, Granier, Françoise, Granier, Michèle, Grasset, Denis, Gravet, Alain, Grawey, Isabelle, Greder Belan, Alix, Grelaud, Jean-Jacques, Grenet, Karine, Gressier, Bernard, Grignon, Bernadette, Grimprel, Emmanuel, Grise, Geneviève, Grobost, Vincent, Gross Goupil, Marine, Grossi, Olivier, Gruffat, Brigitte, Gruson, Anne, Guénard, Yves, Guérard, Arnaud, Guérin, Bruno, Guérin, Mathilde, Guérin, Claude, Guerquin, Bernard, Guerrot, Dominique, Guéry, Benoît, Gueudet, Philippe, Gueugniaud, Pierre-Yves, Guichard, Isabelle, Guichart, François, Guiden, Ozel, Guider, Bertrand, Guillarmé Grossmann, Pascale, Guillemot, François, Guillet, Pierre, Guillet-Caruba, Christelle, Guillois, Bernard, Guilloy, Olivier, Guimard, Thomas, Guimard, Karine, Guimier, Philippe, Guinard, Jérôme, Guinet, François, Guisset, Olivier, Guitteaud, Karine, Gutmann, Laurent, Guyetand, Severine, Haccourt, Fabian, Hacot, Jean-Pierre, Hadou, Tahar, Haiat, Stéphanie, Haioun, Corinne, Hajjar, Mostapha, Hamitou, Zakaria, Hammami, Sarah, Hamon-Charles, Sophie, Hamou-Plotkine, Laurence, Hanouz, Jean-Luc, Harbi, Samia, Harlé, Jean-Robert, Haro, Sophie, Harou, Christian, Harvey, Thierry, Hatem, Ghada, Hausermann, Marie-Hélène, Hauss, Pierre-Alexandre, Hayoun, Fabrice, Hecham, Moussa, Heches, Xavier, Hedjem, Nourredine, Heidt, Anne, Heisel, Nicolas, Heluwaert, Fréderic, Helvadjian, Thierry, Henni, Tawfiq, Henry-Andrieu, Yanne, Hequet, Delphine, Herbecq, Patrick, Herbrecht, Raoul, Hernu, Romain, Herry, Catherine, Herry, Jean-Paul, Herson, Serge, Heurtaux, Marie-Noelle, Heusse, Emmanuelle, Heyraud-Blanchet, Catherine, Hichri, Yoar, Hilbert, Gilles, Hili, Marie-Thérèse, Hiret, Sandrine, Hittinger, Gilles, Hochart, Anne-Cécile, Hodee, Nathalie, Holstein, Anne, Hombrouk-Alet, Cécile, Hominal, Stéphane, Honderlick, Patrick, Honoré Bouakline, Stéphanie, Hory, Bernard, Hourdebaigt-Larrusse, Pierre, Houssaye, Serge, Houssiaux-Maisonneuve, Nathalie, Hrichi, Abdelkader, Hubert, Didier, Huc, Benoît, Humbert, Karine, Hurel, Dominique, Husson-Wetzel, Stéphanie, Hutin, Pascal, Huttin, Bernard, Hyerle, Laura, Iacobelli, Silvia, Ilunga, Serge, Imbert, Guenièvre, Jabre-Sikias, Elias, Jacob, Jean-Louis, Jacobs, Romain, Jacomy, Dominique, Jacquier, Pascal, Jacquier, Hervé, Jaffarbandjee, Marie-Christine, Jamet, Angéline, Jan, Didier, Jang, Guyro, Jaouen, Anne-Christine, Jardel, Henry, Jarlier, Vincent, Jarrige, Luc, Jarrousse, Bernard, Jauhlac, Benoît, Jault, Véronique, Jault, Thierry, Jaunait, Eric, Javouhey, Etienne, Jean, Rodolphe, Jean, Julie, Jean-Pierre, Hélène, Jeanmaire, Eliette, Jeannot, Katy, Jeddi, Hassen, Jego, Mickael, Jennane, Selim, Join-Lambert, Olivier, Joly, Pascal, Jonquet, Olivier, Josien, Eric, Jouatte, Fabienne, Jouffret, Agnès, Jourde-Chiche, Noémie, Jourdes, Emilie, Jouvencel, Philippe, Jouzel, Charlotte, Julienne, Geneviève, Jullian, Eric, Juven, Agnès, Juvin, Philippe, Kaidomar, Michel, Kaiser, Thomas, Kalfon, Pierre, Kaltenbach, Georges, Kamar, Nassim, Kansau, Imad, Kara, Ali, Karaoui, Leila, Karirisi, Apollinaire, Karkous, Bernard, Kassis, Marie, Kayal, Samer, Keller, Marie, Kemenar, Chrystelle, Kennouche, Samir, Kerchache, Aissa, Kerleau, Jean-Marc, Kervegant, Anne-Gaelle, Khalifa-Thellier, Sandrine, Radhouane-Khanjari, Fethi, Kherouf, Hakim, Khodeir, Nordine, Kibbrecht, Eric, Kim, An, Kisterman, Jean-Paul, Kittschke, Bernard, Klapczynski, Frédéric, Kodzin, Marie-José, Konate, Bano, Kouaho, Sylvain, Koulmann, Laurence, Krechiem, Karim, Kubab, Sarah, Kubiak, Charles, Kurtz, Jean-Emmanuel, Labadie, Philippe, Labarrière, Damien, Labaune-Kiss, Andrea, Labé, Aurélie, Labourdette, Isabelle, Labrousse, Philippe, Labussière, Anne-Sophie, Lachenal, Florence, Lacroix, Jérôme, Lafeuillade, Alain, Lafforgue, Marie-Odile, Lafon, Ingrid, Lagasse, Jean-Pierre, Lagrandeur, Julien, Lalot, Jean-Marc, Lalu, Mélissa, Laluque, Simone, Lamache, Sébastien, Lamarca, Richard, Lamberet, Aurore, Lambert, Thierry, Lambiotte, Fabien, Lamia, Bouchra, Lamoine-Gimet, Ghislaine, Lamour, Armelle, Lamy, Brigitte, Lanba, Patrice, Landgraf, Nathalie, Landraud, Luc, Laporte, Jean-Patrick, Larible, Claire, Larrazet, Fabrice, Larroche, Claire, Lasbasses, Claudine, Lassel, Ludovic, Lassere, Bertrand, Laudat, Patrice, Lauque, Dominique, Laurens, Etienne, Laurent, Frédéric, Lauretta, Raphael, Laurin, Max, Lauzanne, Brigitte, Lavalard, Emmanuelle, Lavenu, Isabelle, Lavigne, Jean-Philippe, Le Baron, François, Le Berre, Rozenn, Le Berruyer, Pierre-Yves, Le Bideau, Marc, Le Boterff, Cécile, Le Chevallier, Sylvain, Le Coustumier, Alain, Le Du, Anne, Le Goff, Valérie, Le Henaff, Catherine, Le Lay, Geneviève, Le Maout, Gilles, Le Pierres, Athéna, Le Pimpec, Patricia, Le Poulain, Marguerite, Le Reste, Anne-Marie, Le Sec, Ludovic, Le Turdu, Françoise, Leautez-Nainville, Sophie, Lebas, Eddy, Leblond, Véronique, Lebreton, Marie-Annick, Lebreton, Didier, Lecaillon-Thibon, Evelyne, Lechat, Sylvie, Lechiche, Catherine, Lecis, Alain, Leclercq, Roland, Lecomte, Claire, Lécuyer, Hervé, Ledru, Sylvie, Leduc, Dominique, Leflon, Véronique, Lefort, Christine, Lefranc, Hélène, Lefrant, Jean-Yves, Legendre, Christophe, Legoff, Isabelle, Legout, Laurence, Legrand, Mathieu, Legras, Annick, Legros, Antoine, Leguen, Virginie, Leibinger, Franck, Lelièvre, Jean-Daniel, Lellouche, Franck, Lemaignen, Adrien, Lemarie, Romain, Lemble, Chantal, Lemenand, Olivier, Lemercier, Fanny, Lemery, Didier, Lemmens, Bruno, Lemyze, Malcolm, Leneveu, Michel, Léonetti, Françoise, Léonnet, Caroline, Léotard, Sophie, Lepeletier, Didier, Lepelletier, Didier, Lepeule, Raphael, Lepiller, Quentin, Lequen, Laurence, Leroux, Lionel, Leroux, Stéphane, Leroy, Hélène, Leroy, Vincent, Leroy, Olivier, Lesage, Fabrice, Lescat, Mathilde, Lesecq, Ludovic, Lessene, Aude, Lessinger, Jean-Marc, Letellier, Claire, Letellier, Nicolas, Letouzey, Vincent, Letranchant, Lorraine, Levast, Marion, Leveneur, Yann, Levent, Thierry, Levy, Marie, Levy, Marc, Leysenne, David, Libeau, Benoît, Likose, Ebutu, Lima, Suzanne, Lina, Gérard, Lioger, Bertrand, Lionnet, Benoît, Lipovac, Anne-Sophie, Loffeier, Vincent, Loison, Françoise, Lorchleac'h, Aurélien, Lorge, Fabienne, Loriferne, Jean-François, Lorléa'ch, Aurélien, Louart, Guillaume, Loury-Lariviere, Isabelle, Loustaud, Véronique, Lozniewski, Alain, Luciani, Roger-Charles, Luminitan Elena Lupean, Luca, Lureau, Pierre, Lutz-Murphy, Marie-France, Mbimba, Luwawu, M'Bey, Damien, Maakaroun, Abdallah, Macci, Valérie, Magdoud, Fatma, Mager, Guy, Magna, Théophile, Magny, Jean-François, Mahaza, Chetaou, Mahé, Isabelle, Maillard, Christine, Maillet, Jean-Jacques, Maillet, François, Maillez, Sébastien, Maillot, François, Maisonneuve, Antoine, Makdessi, Solène, Malbrunot, Claire, Malbruny, Brigitte, Malderet, Caroline, Malfuson, Jean-Valère, Malherbe, Philippe, Malherbe, Patrick, Malhiere, Sophie, Mandelbrot, Laurent, Mandin, Laurent, Mandjee, Aziza, Manéglier, Benjamin, Mansouria, Mohammed, Marcu, Elena, Mariette, Jean-Bernard, Mariette, Sylvie, Markarian, Jacques, Marmouset, Carole, Marpeau, Olivier, Marret, Olivier, Marsepoil, Thierry, Marterl-Lafay, Isabelle, Martha, Benoît, Marthelet, Patrick, Martin, Xavier, Martin, Florence, Martin, Pierre, Martin, Régine, Martin, Christian, Martin Lefèvre, Laurent, Martineau, Olivier, Martinet, Olivier, Martinez, Valérie, Martinot, Martin, Martres, Pascale, Marty, Sophie, Marty-Ane, Charles, Marzouk, Paul, Mascade, Géraldine, Masia, Florent, Masseron, Thierry, Masson, Loïc, Masson, Philippe, Matheron, Isabelle, Matica, Slavius, Matray, Olivier, Mattei, Marie-Françoise, Maubert, Bertrand, Maugein, Jeanne, Maureira, Juan-Pablo, May, Thierry, May, Adrien, Maze, Vincent, Meaudre Desgouttes, Eric, Mebazaa, Alexandre, Mechai, Frédéric, Medeau, Virginie, Megbemado, Richard, Mehri, Mona, Mein-Bottini, Myriam, Melis, Adrien, Mellier, Joelle, Ménager, Philippe, Ménard, Céline, Mendes-Martin, Lucile, Menguy, Anne-Claude, Menouar, Mohamed, Merabet, Taoufik, Mercury, Paul, Meregnani, Corinne, Mérigot, Philippe, Mermont, Sylvain, Merrouche, Yacine, Merville, Pierre-Gilles, Mesnage, Renaud, Mesnard, Louis, Messager, Aurélie, Messiaen, Thierry, Messika, Jonathan, Messner Pellenc, Patrick, Métenier, Hervé, Metton, Pierre, Meyer, Christian, Mialon, Michel, Miatello, Jordi, Michaud-herbst, Alban, Michault, Alain, Micheli, Sophie, Michon, Jocelyn, Baptiste Michot, Jean, Mielczarek, Severine, Mignart, Sophie, Mignaut, Virginie, Migraine Bouvagnet, Audrey, Mihout, Fabrice, Mille, Catherine, Millet, Olivier, Milpied, Noel, Mimoz, Olivier, Minet, Jacques, Minguet, Bertrand, Mohty, Mohamad, Moiton, Marie-Pierre, Monarchi, Richard, Monceau, Yannick, Monchi, Mehran, Monlun, Eric, Monsegu, Jacques, Montagne, Nathalie, Montcriol, Ambroise, Montmasson, Bernard, Mootien, Paramasiven, Moquet, Olivier, Morando, Virginie, Moreau, Anne-Sohie, Morel, Yves, Morelon, Emmanuel, Morin-Fatome, Armelle, Morincomme, Mathieu, Morlat, Philippe, Mosser, Laurent, Motard-Picheloup, Annie, Mottaz, Philippe, Moulinoux, Claire, Mouly, Laurence, Mourad, Georges, Mouries, Jean-Claude, Moussa, Hecham, Moustache, Audrey, Muir, Jean-François, Murbach, Valérie, N'guyen, Yohann, N'guyen, Jean-Claude, N'guyen-Khac, Florence, Nabholtz, Jean-Marc, Naceur, Tarik, Nakhleh, Jean, Nare, Aline, Nassif, Xavier, Nathan-Bonnet, Frédérique, Negrery, Huguette, Negrier, Claude, Neri, Dominique, Nesrine, Hakima, Neuwirth, Catherine, Ngami, Eugène, Carole Ngo Bell, Elisabeth, Nicobaharaye, Dieudonné, Nicolet, Laurent, Nicolet, Laurence, Nicolino, Marc, Niel, Philippe, Nikodijevic, Karine, Nkunzimana, Jean-Marie, Noel, Christian, Noirot, Alain, Noto, Philippe, Noulard, Marie-Noelle, Ntalu Nkato, Christophe, Nyunga, Martine, Obiols, Julien, Ochocki, Patrick, Odent, Sylvie, Olivier, Brigitte, Oliviero, Gérard, Ondze, Basile, Orléva, Oléna, Orode, Paul, Osman, Henri, Oswald, Eric, Otean, Paola, Ouazir, Abderkader, Ozanon, Christophe, Paccalin, Marc, Pages, Marie-Christine, Paindaveine, Bénédicte, Pangon, Béatrice, Pannecouck, Jean-Marie, Paquet, Jean-Christophe, Parent, Sabrina, Parisi-Duchene, Elisabeth, Pasche, Jérôme, Pasdeloup, Thierry, Patin, David, Patrigeon, René-Gilles, Patry, Isabelle, Paul, Jean-Gabriel, Pavel, Simona, Pavic, Michel, Pawlotsky, Jean-Michel, Payan, Christopher, Payen, Christiane, Péan, Yves, Péchinot, Frédérique, Péchinot, André, Pecquet, Matthieu, Pélaquier, Agnès, Peltier, Hervé, Penn, Pascale, Pennaforte, Jean-Loup, Perez, Didier, Périsson, Caroline, Perotin, Dominique, Perouse de Montclos, Michèle, Perreve, Sophie, Perronne, Christian, Perrotin, Dominique, Pesque, Valerie, Pestel-Caron, Martine, Pestre, Vincent, Petassou, Fabrice, Petit, Marie-Cécile, Petit Hoang, Camille, Petitjean, Philippe, Pettinelli, François, Peultier, Anne-Sophie, Piala, Jean-Marie, Pialoux, Gilles, Piau, Caroline, Picard, Aurélia, Picaud, Jean-Charles, Pichard, Eric, Pierre, Martin, Pierre, Fabrice, Pierrot, Paul, Piet, Emilie, Piffaut, Marie-Claude, Pigeon, Bertrand, Pignon, Carole, Pinon, Georges, Piquet, Jacques, Piriou, Vincent, Placidi, Eric, Plainfosse, Gillles, Plane, Christophe, Plantier, Isabelle, Claudiu-Plesa, Nicolai, Plésiat, Patrick, Plessis, Patrick, Plouzeau-Jayle, Chloé, Ploy, Marie-Cécile, Pochmalicki, Gilbert, Pofelski, Joanna, Poinsignon, Yves, Poirier, Anne-Sophie, Poitevin, Françoise, Pommier, Christian, Ponceau, Bénédicte, Poncelet, Christophe, Pop, Daniela, Porcheron, Martine, Pordes, Réginald, Porthault, Eric, Portneuf, Marc, Pottier, Anne, Pouedras, Pascal, Poulain, Jocelyne, Poulain, Gérard, Poupet, Hélène, Pouyanne, Julien, Pouzoullic, Marie, Poyart, Claire, Pozzetto, Bruno, Prazuck, Thierry, Pressac, Dominique, Prévost, Fabrice, Prince, Sylvie, Priollet, Pascal, Proost, Olivier, Protar, Daniel, Pujade Lauraine, Eric, Pujol, Antoine, Puybasset, Louis, Puyhardy, Jean, Quentin, Vincent, Quinsat, Denis, Rabier, Valérie, Radaoui, Fouzia, Radenac, Florian, Radenne, Sylvie, Raffenot, Didier, Raffi, François, Rahmani, Hassène, Ramanantsoa, Céline, Ranchon, Guillaume, Ranta, Dana, Raoult, Didier, Rasigade, Jean-Philippe, Rassiat, Emmanuel, Raulin, Olivia, Ravaud, Alain, Ravet, Nathalie, Razafimahefa, Hasinrina, Razafimahery, Mirana, Re, Daniel, Real, Philippe, Rebattu, Paul, Rebeyrotte, Catherine, Reboul, Pascal, Reboux, Anne-Hélène, Recule, Christine, Redonnet, Jean-Philippe, Redor, Alexis, Regouby, Yves, Rémy, Claude, Renard, Gisèle, Renard, Benoît, Renou, Frédéric, Repellin, Philippe, Reveil, Jean-Claude, Revel, Valérie, Reverseau, Anne, Revest, Mathieu, Rey, Philippe, Rey, Hyacine, Rey Zermati, Jany, Reyes Ortega, Guillermo, Reynaud, Alain, Reynes, Jacques, Rezgui, Nasseur, Riahi, Jacques, Ribes, David, Ribier, Arnaud, Richard, Christian, Richardin, Florence, Riche, Agnès, Richette, Pascal, Ridah, Khalid, Riegel, Philippe, Riehl, Frédéric, Rigaux, Françoise, Rioux, Christophe, Rival, Gilles, Rivière, Brigitte, Robert, Henri, Robert, René, Robillard, Pierre-Yves, Roblin, Mélanie, Roblot, Pascal, Roblot, France, Rogeaux, Olivier, Roger, Pierre-Marie, Rohmer-Heitz, Dominique, Rolland, Christophe, Roncato-Saberane, Mariam, Ronda, Isabelle, Rondepierre, Philippe, Roque-Afonso, Anne-Marie, Rosay, David, Rose, Christian, Roseau, Jean-Baptiste, Rosello, Sophie, Rosselli, Sylvène, Rossignol, Serge, Rostaing, Lionel, Roth, Christian, Rothe, Marie-Rose, Roubert, Xavier, Rouget, Sébastien, Rouidi, Ahmed, Roulier, Philippe, Rouquet, Yannick, Rouquette-Vincent, Isabelle, Roure Sobas, Chantal, Rousseau, Sylvaine, Rousseau, Florence, Roussel, Etienne, Roussel, Jean-Christian, Roussel, Christophe, Roussellier, Patricia, Roy, Christophe, Royer, Daniel, Roze, Jean-Christophe, Rozec, Bertrand, Ruimy, Raymond, Ruppé, Etienne, Ruyer, Olivier, Sabbat, Sébastien, Saghi, Tahar, Saigne, Christophe, Sakek, Necera, Salama, Gilles, Salanoubat, Celia, Salaun-Beretta, Guenaelle, Saliba, Elie, Salles, Gilles, Salmon, Odile, Louis Salomon, Jean, Salord, Jean-Michel, Salvucci, Marina, Samson, Thierry, Sanchez, Richard, Sansot, Dominique, Saplacan, Mihaela, Saroufim, Carlo, Sauder, Philippe, Sautereau, Denis, Savare, Ferdinand, Savatier, Rim, Scemla, Anne, Schendel, Adeline, Schmitt, Anna, Schmitt, François, Schmitt, Alain, Schneerson, Morgane, Schneider, Francis, Schved, Jean-François, Schwebel, Carole, Sebban, Anthony, Secher, Aline, Sédillot, Nicholas, Sedjelmaci, Yacine, Segonds, Christine, Seignovert, Camille, Seknazi, Corinne, Semenescu, Marius, Sément, Arnaud, Semet, Jean-Claude, Semet, Guy, Sennevile, Eric, Serier, Miloud, Serre, Arnaud, Seta, Nathalie, Seyrig, Jacques-Arnaud, Sgro, Eric, Sibony-Prat, Joyce, Sicsic, Jean-Luc, Sifaoui, Farid, Signouret, Thomas, Sigur, Nicolas, Silhadi, Souad, Siméoni, Umberto, Simian, Bernard, Similowski, Thomas, Simon, Georges, Simon, François, Simonin, Catherine, Sirbu, Cristina, Sire, Jean-Marie, Sivadon-Tardy, Valérie, Sivery, Bruno, Slama, Michel, Smati, Salim, Sobesky, Rodolphe, Sokeng-Affoule, Hélène, Sollet, Jean-Pierre, Sommabère, André, Sondag, Daniel, Soraudeau, Florence, Sotto, Albert, Soulie, Bruno, Souply, Laurent, Souquet, Jean-Christophe, Soury, Pierre, Souweine, Bertrand, Stahl, Jean-Paul, Steibach, Marie-Isabelle, Stephan, Robin, Stoclin, Annabelle, Stolidi, Philippe, Strock, Paul, Suatean, Diana, Subra, Jean-François, Sucin, Yves, Suel, Philippe, Sullice, Marc, Szwebel, Tali-Anne, Tacchini, Laurent, Talabani-Boizot, Hana, Talarmin, Jean-Philippe, Taleb, Fethi, Tamalet, Catherine, Tamion, Fabienne, Tandonnet, Olivier, Tankovic, Jacques, Tardy, Véronique, Tassot, Christelle, Taurin, Gregory, Taylor, Sabine, Tchenio, Xavier, Tebib, Jacques, Teillet, Laurent, Teixeira, Antonio, Terki, Mustapha, Tesseydre, Sonia, Texier, Jean-Claude, Texier, Anthony, Thellier, Jean-Paul, Thibaud, Didier, Thibault, Michel, Thibaut, Freddy, Thierry, Jacques, Thoinet, Sylvie, Thomas, Pierre, Thomas, René, Thomas, Yves, Thomas, Caroline, Thore, Jean, Thouret, Jean-Marc, Thouvenin, Maxime, Thuet, Francis, Tigaizin, Ahmed, Tigaud, Sylvestre, Tiry, Catherine, Tissieres, Pierre, Tissot, Alain, Tixier, Anne, Touati, Kamel, Toubia, Marie-Lina, Toullalan, Olivier, Tourani, Jean-Marc, Tourrand, Bernadette, Touze, Yvan, Trabelsi-Jnifen, Asma, Traissac, Laurent, Anh Tran, Tu, Tran, Vanessa, Tricoire, Joelle, Tronchon, Laurent, Trouiller, Sébastien, Trystram, David, Ahmed, Becaid, Tsouria, Tuca, Mirela, Turpin, Mathilde, Vache, Bernard, Vachée, Anne, Vaillant, Christine, Valadier, Patrick, Valayer, Patrick, Valette, Xavier, Vallet, Françis, Van de Velde, Florence, Vanden Einjden, Serge, Vandenesch, François, Vande-perre, Philippe, Varin, Marie-Christine, Vary, Gwenaelle, Vaschalde, Yvan, Vassallo, Matteo, Vasse, Marc, Vasseur, Manica, Vatan, Rémi, Vaucel, Jacques, Vergnaud, Michel, Verhaeghe, Annick, Vermesch-Langlin, Annie, Vernet, Guy, Vernet Garnier, Véronique, Verrier, Virginie, Vessieres, Annie, Vialette, Véronique, Viard, Jean-Paul, Vieillard Baron, Antoine, Vighetto, Alain, Villemain, Marc, Villers, Daniel, Vilque, Jean-Pierre, Vinay, Agnès, Vincent, Didier, Vincent, Pascal, Vincent, Colette, Vincent, Simon, Vinci, Clara, Viole, Didier, Violette, Jérémie, Viquesnel, Gerard, Virlouvet, Anne-Laure, Visentin, Séverine, Vittecoq, Daniel, Vodovar, Dominique, Vrigneaud, Laurence, Vu-Thien, Hoang, Vuotto, Fanny, Wafo, Estelle, Wagner, Michel, Walid, Nicola, Walter, Elisabeth, Watson, Sarah, Weinbreck, Pierre, Weinbronn, Eva, Weiss, Emmanuel, Weitten, Thierry, Welker, Yves, Westeel, Pierre-François, Wink, Olivier, Wintenberger, Claire, Woerther, Paul-Louis, Worcel, Isabelle, Wuillai, Anne, Wurmser, Marc, Xavier, Jacob, Yazdanpanah, Yazdan, Yehia, Aihem, Yvenou, Sterenn, Zagdoun, Elie, Zagozda, Dominique, Zame, Thierry-Pascal, Zamfiri, Oana, Zanaldi, Hélène, Zandecki, Marc, Zaoui, Eric, Zarrouk, Virginie, Zarski, Jean-Pierre, Zavadil, Patrick, Zeller, Valérie, Zerbib, Franck, Zerr, Vincent, Zgarni, Lémia, Zoulim, Fabien, Zoveda, Patrick, Zuber, Pierre, Zumbo, Christian, Charlier, Caroline, Perrodeau, Élodie, Leclercq, Alexandre, Cazenave, Benoît, Pilmis, Benoît, Henry, Benoît, Lopes, Amanda, Maury, Mylène M, Moura, Alexandra, Goffinet, François, Dieye, Hélène Bracq, Thouvenot, Pierre, Ungeheuer, Marie-Noëlle, Tourdjman, Mathieu, Goulet, Véronique, de Valk, Henriette, Lortholary, Olivier, Ravaud, Philippe, and Lecuit, Marc

Published
2017
Full Text
View/download PDF

10. Use of glucocorticoids in rheumatoid arthritis – Pratical modalities of glucocorticoid therapy: Recommendations for clinical practice based on data from the literature and expert opinion

Author

Dernis, Emmanuelle, Ruyssen-Witrand, Adeline, Mouterde, Gaël, Maillefert, Jean-Francis, Tebib, Jacques, Cantagrel, Alain, Claudepierre, Pascal, Fautrel, Bruno, Gaudin, Philippe, Pham, Thao, Schaeverbeke, Thierry, Wendling, Daniel, Saraux, Alain, and Loët, Xavier Le

Published
2010
Full Text
View/download PDF

12. Prognosis and follow-up of psoriatic arthritis with peripheral joint involvement: Development of recommendations for clinical practice based on published evidence and expert opinion

Author

Lavie, Frédéric, Salliot, Carine, Dernis, Emmanuelle, Claudepierre, Pascal, Schaeverbeke, Thierry, Tebib, Jacques, Goupille, Philippe, Cantagrel, Alain, Flipo, René-Marc, Gaudin, Philippe, Le Loët, Xavier, Maillefert, Jean-Francis, Paul, Carle, Saraux, Alain, Wendling, Daniel, and Combe, Bernard

Published
2009
Full Text
View/download PDF

13. Pharmacological treatment (biotherapy excluded) of peripheral psoriatic arthritis: Development of recommendations for clinical practice based on data from the literature and experts opinion

Author

Dernis, Emmanuelle, Lavie, Frédéric, Salliot, Carine, Flipo, René-Marc, Saraux, Alain, Maillefert, Jean-Francis, Paul, Carle, Goupille, Philippe, Cantagrel, Alain, Claudepierre, Pascal, Gaudin, Philippe, Tebib, Jacques, Wendling, Daniel, Schaeverbeke, Thierry, Le Loët, Xavier, and Combe, Bernard

Published
2009
Full Text
View/download PDF

15. Use of Whole-Blood Transcriptomic Profiling to Highlight Several Pathophysiologic Pathways Associated With Response to Rituximab in Patients With Rheumatoid Arthritis: Data From a Randomized, Controlled, Open-Label Trial

Author

Sellam, Jérémie, Marion-Thore, Sandrine, Dumont, Florent, Jacques, Sébastien, Garchon, Henri-Jean, Rouanet, Stéphanie, Taoufik, Yassine, Hendel-Chavez, Houria, Sibilia, Jean, Tebib, Jacques, Le Loët, Xavier, Combe, Bernard, Dougados, Maxime, Mariette, Xavier, and Chiocchia, Gilles

Published
2014
Full Text
View/download PDF

17. Langerhans cell histiocytosis reveals a new IL-17A-dependent pathway of dendritic cell fusion

Author

Coury, Fabienne, Annels, Nicola, Rivollier, Aymeric, Olsson, Selma, Santoro, Alessandra, Speziani, Carole, Azocar, Olga, Flacher, Monique, Djebali, Sophia, Tebib, Jacques, Brytting, Maria, Egeler, R Maarten, Rabourdin-Combe, Chantal, Henter, Jan-Inge, Arico, Maurizio, and Delprat, Christine

Subjects
Langerhans-cell histiocytosis -- Research, Dendritic cells -- Research, Flow cytometry -- Usage, Gene expression -- Research, Lymphadenopathy -- Research, Interleukins -- Research
Abstract

IL-17A is a T cell-specific cytokine that is involved in chronic inflammations, such as Mycobacterium infection, Crohn's disease, rheumatoid arthritis and multiple sclerosis. Mouse models have explained the molecular basis of IL-17A production and have shown that IL-17A has a positive effect not only on granuloma formation and neurodegeneration through unknown mechanisms, but also on bone resorption through Receptor activator of NF-[kappa]B ligand (RANKL) induction in osteoblasts. Langerhans cell histiocytosis (LCH) is a rare disease of unknown etiology, lacking an animal model, that cumulates symptoms that are found separately in various IL-17A-related diseases, such as aggressive chronic granuloma formation, bone resorption and soft tissue lesions with occasional neurodegeneration. We examined IL-17A in the context of LCH and found that there were high serum levels of IL-17A during active LCH and unexpected IL-17A synthesis by dendritic cells (DCs), the major cell type in LCH lesions. We also found an IL-17A-dependent pathway for DC fusion, which was highly potentiated by IFN-[gamma] and led to giant cells expressing three major tissue-destructive enzymes: tartrate resistant acidic phosphatase and matrix metalloproteinases 9 and 12. IFN-[gamma] expression has been previously documented in LCH and observed in IL-17A-related diseases. Notably, serum IL-17A-dependent fusion activity correlates with LCH activity. Thus, IL-17A and IL-17A-stimulated DCs represent targets that may have clinical value in the treatment of LCH and other IL-17A-related inflammatory disorders., Author(s): Fabienne Coury [1, 2, 3, 4, 5]; Nicola Annels [6]; Aymeric Rivollier [1, 2, 3, 4]; Selma Olsson [7]; Alessandra Santoro [8, 9]; Carole Speziani [1, 2, 3, 4]; [...]

Published
2008
Full Text
View/download PDF

32. Factors influencing the prescription of Tocilizumab alone or in combination with Dmards in rheumatoid arthritis patients in a real life setting. Pooled analysis of 2 observational studies

Author

Saraux, Alain, Flipo, René-Marc, Combe, Bernard, Tebib, Jacques, Baffie, Christelle, Idier, Isabelle, Cantagrel, Alain, CHRU Brest - Service de Rhumatologie (CHU - BREST - Rhumato), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Lymphocyte B et Auto-immunité (LBAI), Université de Brest (UBO)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM), Département de Rhumatologie (LILLE - Rhumatologie), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Hôpital Lapeyronie [Montpellier] (CHU), Hospices Civils de Lyon (HCL), Altizem on behalf of Roche, Boulogne Billancourt, Chugai Pharma France, Paris La Défense, Department of Rheumatology, Purpan Toulouse, Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO), and Michel, Geneviève

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2017

33. Isolated positive anti-SS-B autoantibodies are not related to clinical features of systemic autoimmune diseases

Author

Jardel, Sabine, Fabien, Nicole, Hot, Arnaud, Vukusic, Sandra, Tebib, Jacques, Cottin, Vincent, Seve, Pascal, Laville, Maurice, Belot, Alexandre, Durieu, Isabelle, Garnier, Lorna, Coutant, Frédéric, Reynaud, Quitterie, Lega, Jean-Christophe, Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL), Hôpital Edouard Herriot [CHU - HCL], Hôpital neurologique et neurochirurgical Pierre Wertheimer [CHU - HCL], Infections Virales et Pathologie Comparée - UMR 754 (IVPC), Institut National de la Recherche Agronomique (INRA)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Hôpital Louis Pradel [CHU - HCL], Hôpital de la Croix-Rousse [CHU - HCL], Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital Femme Mère Enfant [CHU - HCL] (HFME), Evaluation et modélisation des effets thérapeutiques, Département biostatistiques et modélisation pour la santé et l'environnement [LBBE], Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS), Institut National de la Recherche Agronomique (INRA)-École pratique des hautes études (EPHE)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hospices Civils de Lyon (HCL), and Institut National de la Recherche Agronomique (INRA)-École Pratique des Hautes Études (EPHE)

Subjects
[SDV]Life Sciences [q-bio]
Abstract

International audience; Objective : To assess in clinical practice the frequency and diagnosis associated with the SS-B-positive/SS-A negative autoantibody profile. Methods : We analyzed a one-year consecutive population of 624 patients referred by clinicians to the immunology laboratory to investigate anti-SS-A and/or anti-SS-B autoantibodies, who were detected using luminex technology. Data were analyzed for patients with isolated anti-SS-B autoantibodies. The clinical characteristics and diagnosis of connective tissue diseases (CTD) were retrieved according to the international criteria. Results : Among 1173 sera positive for anti-SS-A and/or anti-SS-B autoantibodies from 624 patients, we identified 84 patients (13.5%) that had isolated anti-SS-B. Among the 75 patients positive for anti-SS-B with known clinical data, 15 were diagnosed with a CTD (20%) including 4 systemic lupus erythematosus (5%), 4 rheumatoid arthritis (5%), 2 idiopathic inflammatory myositis (3%), 1 primary Sjogren's syndrome pSS (1%), 1 systemic sclerosis (1%), 2 undefined CTD (3%), and 1 mixed CTD (1%). Among the 60 other patients, 18 had non-CTD autoimmune diseases and 42 had non-autoimmune diseases. Within the CTD population, the presence of isolated anti-SS-B was not significantly associated to characteristic indicating a specific syndrome. There was no association between diagnosis of CTD and level of anti-SS-B autoantibodies (p = 0.70). Arthralgia was the more frequent sign and encountered in 10 patients (67%), of whom 3 had arthritis. Conclusion : The presence of anti-SS-B, without anti-SS-A autoantibodies using luminex technology, was not associated with CTD, especially pSS, in daily clinical practice. Our data suggests that the SS-B serological profile is not contributive for the classification criteria of pSS.

Published
2017
Full Text
View/download PDF

37. Value of ultrasonography as a marker of early response to abatacept in patients with rheumatoid arthritis and an inadequate response to methotrexate: results from the APPRAISE study

Author

Nguyen, Minh Vu Chuong, Romand, Xavier, Trocme, Candice, Courtier, Anaïs, Marotte, Hubert, Thomas, Thierry, Miossec, Pierre, Tebib, Jacques, Grange, Laurent, Toussaint, Bertrand, Gaudin, Philippe, Nourisson, Cynthia, Soubrier, Martin, Mulliez, Aurelien, Baillet, Athan, Bardin, Thomas, Combe, Bernard, Dougados, Maxime, Flipo, René-Marc, Ravaud, Philippe, Tournadre, Anne, Derambure, C., Dzangue-Tchoupou, G., Bérard, C., Vergne, N., Hiron, M., D’Agostino, M., Musette, P., Lequerré, Thierry, Ruyssen-Witrand, Adeline, Degboé, Yannick, Cantagrel, Alain, Nigon, D., Lukas, C., Scaramuzzino, S, Allanore, Y., Schaeverbeke, Thierry, Morel, J., Sibilia, Jean, Cambon-Thomsen, A., Dieudé, P., Constantin, A, Nocturne, G., Virone, A., Ng, Wan-Fai, Le Guern, V., Hachulla, E., Cornec, D., Daien, C., Bienvenu, B., Marcelli, C., Wendling, D., Amoura, Z., Dhote, R., Lavigne, C., Fior, R., Gottenberg, Jacques-Eric, Seror, R., Mariette, Xavier, Eble, V., Legallicier, B., Joly, P., Caron, F., Tamion, F., Ducrotté, P., Lévesque, H., Ménard, J.-F., Jouen, F., Guerrot, D., Marié, I., D'Agostino, Maria-Antonietta, Wakefield, Richard, Berner-Hammer, Hilde, Vittecoq, Olivier, Filippou, Georgios, Bálint, Péter, Möller, Ingrid, Iagnocco, Annamaria, Naredo, Esperanza, Ostergaard, Mikkel, Boers, Maarten, Gaillez, Corine, Van Holder, Karina, Le Bars, Manuela, Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525 (TIMC-IMAG), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Université Grenoble Alpes - UFR Médecine (UGA UFRM), Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Thérapeutique Recombinante Expérimentale (TIMC-IMAG-TheREx), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Groupe de Recherche et d'Etude du Processus Inflammatoire (GREPI), Centre National de la Recherche Scientifique (CNRS)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Service de Rhumatologie [Saint-Etienne], Hôpital de Bellevue-CHU Saint-Etienne, Service d'Endocrinologie [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Department of Immunogenomics, Mixed Unit HCL-BioMerieux, Hopital E. Herriot, Hospices Civils de Lyon (HCL), Service de Rhumatologie, Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble-Hôpital Michallon, Service de rhumatologie, CHU Clermont-Ferrand, Direction de la recherche clinique et de l’innovation [CHU Clermont-Ferrand] (DRCI), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Hôpital Lapeyronie [Montpellier] (CHU), Service de rhumatologie [CHU Cochin], Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Hôpital Claude Huriez [Lille], CHU Lille-CHU Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Modèles et méthodes de l'évaluation thérapeutique des maladies chroniques (U738 / UMR_S738), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Diderot - Paris 7 (UPD7), Unité de Nutrition Humaine (UNH), Université d'Auvergne - Clermont-Ferrand I (UdA)-Clermont Université-Institut National de la Recherche Agronomique (INRA), Génomique et Médecine Personnalisée du Cancer et des Maladies Neuropsychiatriques (GPMCND), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital Femme Mère Enfant [CHU - HCL] (HFME), Laboratoire de Mathématiques Raphaël Salem (LMRS), Normandie Université (NU)-Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS), Service de rhumatologie [CHU Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Physiopathologie, Autoimmunité, maladies Neuromusculaires et THErapies Régénératrices (PANTHER), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU), CHU Toulouse [Toulouse], Service de rhumatologie et réadaptation fonctionelle, CHU Toulouse [Toulouse]-Hôpital Purpan [Toulouse], Hôpital Purpan [Toulouse], Centre de rhumatologie, CHU Purpan, Institut Cochin (IC UM3 (UMR 8104 / U1016)), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), CHU Bordeaux [Bordeaux], Département de Rhumatologie[Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Lapeyronie, Service de rhumatologie [Strasbourg], CHU Strasbourg-Hôpital de Hautepierre [Strasbourg], Epidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps (LEASP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Hôpital Bicêtre-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11), Hôpital Bicêtre, Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Bicêtre, Institute of Cellular Medicine [Newcastle], Newcastle University [Newcastle], Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Lymphocyte B et Auto-immunité (LBAI), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO), CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), Service de Rhumatologie [CHU Caen], Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Hôpital Avicenne [AP-HP], Hôpital Antoine Béclère, Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Immuno-Rhumatologie Moléculaire, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Strasbourg (UNISTRA), CHU Le Kremlin-Bicêtre (Rheumatology Department), Department of Rheumatology, Service de Médecine Interne [CHU Rouen], Service de Néphrologie [Rouen], Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM ), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), Service d'Hépato-Gastroentérologie [CHU Rouen], Hôpital Charles Nicolle [Rouen]-CHU Rouen, Unité de biostatistiques [CHU Rouen], Physiopathologie et biothérapies des maladies inflammatoires et autoimmunes, Service de Dermatologie [Rouen], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Ambroise Paré [AP-HP], Academic Unit of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, Chapel Allerton Hospital, Rheumatology Unit [Siena], National Institute of Rheumatology and Physiotherapy, Instituto Poal de Reumatologia, Barcelona, Università degli studi di Torino (UNITO), Fundación Jiménez Díaz, Fundacion Jimenez Diaz [Madrid] (FJD), Center for Rheumatology and Spine Diseases, Copenhagen (Center for Rheumatology and Spine Diseases), VU University Medical Center [Amsterdam], Epidemiology and Data Science, Rheumatology, AII - Inflammatory diseases, Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-IMAG-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Université Grenoble Alpes (UGA), Groupe de Recherche et d'Etudes du Processus Inflammatoire (GREPI), Université Joseph Fourier - Grenoble 1 (UJF), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-IMAG-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-IMAG-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), CHU Saint-Etienne-Hôpital de Bellevue, Délégation à la recherche clinique et aux innovations (DRCI), CHU de Clermont-Ferrand, Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Lariboisière, CHU Cochin [AP-HP]-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP), Hôpital Claude Huriez-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Modèles et méthodes de l'évaluation thérapeutique des maladies chroniques, Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Unité de Nutrition Humaine - Clermont Auvergne (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA), Service de rhumatologie [Rouen], Normandie Université (NU)-Normandie Université (NU)-CHU Rouen, Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Bicêtre, CHU Cochin [AP-HP], Service de Rhumatologie [CHRU de Besançon], Centre Hospitalier Régional Universitaire [Besançon] (CHRU Besançon), Hôpital avicenne, Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Université Paris 13 (UP13)-Hôpital Avicenne, Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Médecine Interne [Rouen], Service d'Hépato-Gastroentérologie [Rouen], Unité de biostatistiques [Rouen], Normandie Université (NU)-Normandie Université (NU)-Hôpital Charles Nicolle [Rouen], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Ambroise Paré, fundacion Jimenez Diaz, VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Cochin [AP-HP], Institut National de la Recherche Agronomique (INRA)-Université d'Auvergne - Clermont-Ferrand I (UdA)-Clermont Université, Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), Lymphocytes B, Autoimmunité et Immunothérapies (LBAI), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-LabEX IGO Immunothérapie Grand Ouest-Institut Brestois Santé Agro Matière (IBSAM), Università degli studi di Torino = University of Turin (UNITO), Service de Rhumatologie [CHU Saint-Etienne], Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E)-Université Jean Monnet - Saint-Étienne (UJM), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Centre de Rhumatologie [CHU Toulouse], Pôle Inflammation, infection, immunologie et loco-moteur [CHU Toulouse] (Pôle I3LM Toulouse), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-LabEX IGO Immunothérapie Grand Ouest, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Institut Brestois Santé Agro Matière (IBSAM), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), Hôpital Charles Nicolle [Rouen], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Cochin [AP-HP], Laboratoire de recherche européen pour la polyarthrite rhumatoïde (GenHotel - EA 3886), Université d'Évry-Val-d'Essonne (UEVE), and Université Paris 13 (UP13)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Avicenne

Subjects
Male, Genetics and Molecular Biology (all), Settore MED/16 - REUMATOLOGIA, [SDV]Life Sciences [q-bio], DMARDs (biologic), Severity of Illness Index, Biochemistry, Arthritis, Rheumatoid, 0302 clinical medicine, Disease Activity, Rheumatoid Arthritis, Ultrasonography, Rheumatology, Immunology, Biochemistry, Genetics and Molecular Biology (all), Immunology and Allergy, Rheumatoid, 030212 general & internal medicine, Prospective Studies, skin and connective tissue diseases, Prospective cohort study, ComputingMilieux_MISCELLANEOUS, Synovitis, biology, Doppler, Middle Aged, 3. Good health, Europe, Treatment Outcome, Rheumatoid arthritis, Antirheumatic Agents, Combination, [SDV.IMM]Life Sciences [q-bio]/Immunology, Drug Therapy, Combination, Female, medicine.symptom, medicine.drug, musculoskeletal diseases, Adult, medicine.medical_specialty, General Biochemistry, Genetics and Molecular Biology, Abatacept, 03 medical and health sciences, Drug Therapy, Predictive Value of Tests, Internal medicine, medicine, Humans, Aged, 030203 arthritis & rheumatology, business.industry, Arthritis, C-reactive protein, Ultrasonography, Doppler, Joint effusion, Clinical and Epidemiological Research, medicine.disease, Methotrexate, biology.protein, Physical therapy, Joints, business, Rheumatism, Biomarkers
Abstract

Objectives To study the responsiveness of a combined power Doppler and greyscale ultrasound (PDUS) score for assessing synovitis in biologic-naive patients with rheumatoid arthritis (RA) starting abatacept plus methotrexate (MTX). Methods In this open-label, multicentre, single-arm study, patients with RA (MTX inadequate responders) received intravenous abatacept (∼10 mg/kg) plus MTX for 24 weeks. A composite PDUS synovitis score, developed by the Outcome Measures in Rheumatology–European League Against Rheumatism (OMERACT–EULAR)-Ultrasound Task Force, was used to evaluate individual joints. The maximal score of each joint was added into a Global OMERACT–EULAR Synovitis Score (GLOESS) for bilateral metacarpophalangeal joints (MCPs) 2–5 (primary objective). The value of GLOESS containing other joint sets was explored, along with clinical efficacy. Results Eighty-nine patients completed the 24-week treatment period. The earliest PDUS sign of improvement in synovitis was at week 1 (mean change in GLOESS (MCPs 2–5): −0.7 (95% CIs −1.2 to −0.1)), with continuous improvement to week 24. Early improvement was observed in the component scores (power Doppler signal at week 1, synovial hyperplasia at week 2, joint effusion at week 4). Comparable changes were observed for 22 paired joints and minimal joint subsets. Mean Disease Activity Score 28 (C reactive protein) was significantly reduced from weeks 1 to 24, reaching clinical meaningful improvement (change ≥1.2) at week 8. Conclusions In this first international prospective study, the composite PDUS score is responsive to abatacept. GLOESS demonstrated the rapid onset of action of abatacept, regardless of the number of joints examined. Ultrasound is an objective tool to monitor patients with RA under treatment. Trial registration number NCT00767325.

Published
2016
Full Text
View/download PDF

40. Variants of genes implicated in type 1 interferon pathway and B-cell activation modulate the EULAR response to rituximab at 24 weeks in rheumatoid arthritis

Author

Juge, Pierre-Antoine, primary, Gazal, Steven, additional, Constantin, Arnaud, additional, Mariette, Xavier, additional, Combe, Bernard, additional, Tebib, Jacques, additional, Dougados, Maxime, additional, Sibilia, Jean, additional, Le Loet, Xavier, additional, and Dieudé, Philippe, additional

Published
2017
Full Text
View/download PDF

45. Infliximab therapy in rheumatoid arthritis and ankylosing spondylitis-induced specific antinuclear and antiphospholipid autoantibodies without autoimmune clinical manifestations: a two-year prospective study

Author

Ferraro-Peyret, Carole, Coury, Fabienne, Tebib, Jacques G, Bienvenu, Jacques, and Fabien, Nicole

Subjects
musculoskeletal diseases, Autoimmunity, Autoantigens, Autoimmune Diseases, Arthritis, Rheumatoid, immune system diseases, ankylosing spondylitis, anti-β2-glycoprotein I autoantibodies, Humans, Spondylitis, Ankylosing, Prospective Studies, skin and connective tissue diseases, Glycoproteins, rheumatoid arthritis, Tumor Necrosis Factor-alpha, Anti-Inflammatory Agents, Non-Steroidal, Antibodies, Monoclonal, DNA, Infliximab, stomatognathic diseases, antiphospholipid autoantibodies, Methotrexate, Immunoglobulin M, beta 2-Glycoprotein I, Antibodies, Antinuclear, Immunoglobulin G, Antibodies, Antiphospholipid, Immunosuppressive Agents, Research Article, Follow-Up Studies
Abstract

Treatment of rheumatoid arthritis (RA) with infliximab (Remicade®) has been associated with the induction of antinuclear autoantibodies (ANA) and anti-double-stranded DNA (anti-dsDNA) autoantibodies. In the present study we investigated the humoral immune response induced by infliximab against organ-specific or non-organ-specific antigens not only in RA patients but also in patients with ankylosing spondylitis (AS) during a two-year followup. The association between the presence of autoantibodies and clinical manifestations was then examined. The occurrence of the various autoantibodies was analyzed in 24 RA and 15 AS patients all treated with infliximab and in 30 RA patients receiving methotrexate but not infliximab, using the appropriate methods of detection. Infliximab led to a significant induction of ANA and anti-dsDNA autoantibodies in 86.7% and 57% of RA patients and in 85% and 31% of AS patients, respectively. The incidence of antiphospholipid (aPL) autoantibodies was significantly higher in both RA patients (21%) and AS patients (27%) than in the control group. Most anti-dsDNA and aPL autoantibodies were of IgM isotype and were not associated with infusion side effects, lupus-like manifestations or infectious disease. No other autoantibodies were shown to be induced by the treatment. Our results confirmed the occurrence of ANA and anti-dsDNA autoantibodies and demonstrated that the induction of ANA, anti-dsDNA and aPL autoantibodies is related to infliximab treatment in both RA and AS, with no significant relationship to clinical manifestations.

Published
2004

Catalog

Books, media, physical & digital resources
See catalog results