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Your search keyword '"Te Winkel, M. L."' showing total 20 results
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20 results on '"Te Winkel, M. L."'

9. Genetic and metabolic determinants of methotrexate-induced mucositis in pediatric acute lymphoblastic leukemia

Author

Den Hoed, M. A H, Lopez-Lopez, E., Te Winkel, M. L., Tissing, W., De Rooij, J. D E, Gutierrez-Camino, A., Garcia-Orad, A., Den Boer, E., Pieters, R., Pluijm, S. M F, De Jonge, R., Van Den Heuvel-Eibrink, M. M., Den Hoed, M. A H, Lopez-Lopez, E., Te Winkel, M. L., Tissing, W., De Rooij, J. D E, Gutierrez-Camino, A., Garcia-Orad, A., Den Boer, E., Pieters, R., Pluijm, S. M F, De Jonge, R., and Van Den Heuvel-Eibrink, M. M.

Published
2015

10. Genetic and metabolic determinants of methotrexate-induced mucositis in pediatric acute lymphoblastic leukemia

Author

PMC Medisch specialisten, Den Hoed, M. A H, Lopez-Lopez, E., Te Winkel, M. L., Tissing, W., De Rooij, J. D E, Gutierrez-Camino, A., Garcia-Orad, A., Den Boer, E., Pieters, R., Pluijm, S. M F, De Jonge, R., Van Den Heuvel-Eibrink, M. M., PMC Medisch specialisten, Den Hoed, M. A H, Lopez-Lopez, E., Te Winkel, M. L., Tissing, W., De Rooij, J. D E, Gutierrez-Camino, A., Garcia-Orad, A., Den Boer, E., Pieters, R., Pluijm, S. M F, De Jonge, R., and Van Den Heuvel-Eibrink, M. M.

Published
2015

11. Aggravated bone density decline following symptomatic osteonecrosis in children with acute lymphoblastic leukemia

Author

den Hoed, M. A. H., primary, Pluijm, S. M. F., additional, te Winkel, M. L., additional, de Groot-Kruseman, H. A., additional, Fiocco, M., additional, Hoogerbrugge, P., additional, Leeuw, J. A., additional, Bruin, M. C. A., additional, van der Sluis, I. M., additional, Bresters, D., additional, Lequin, M. H., additional, Roos, J. C., additional, Veerman, A. J. P., additional, Pieters, R., additional, and van den Heuvel-Eibrink, M. M., additional

Published
2015
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12. Genetic and metabolic determinants of methotrexate-induced mucositis in pediatric acute lymphoblastic leukemia

Author

den Hoed, M A H, primary, Lopez-Lopez, E, additional, te Winkel, M L, additional, Tissing, W, additional, de Rooij, J D E, additional, Gutierrez-Camino, A, additional, Garcia-Orad, A, additional, den Boer, E, additional, Pieters, R, additional, Pluijm, S M F, additional, de Jonge, R, additional, and van den Heuvel-Eibrink, M M, additional

Published
2014
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13. The negative impact of being underweight and weight loss on survival of children with acute lymphoblastic leukemia

Author

den Hoed, M. A. H., primary, Pluijm, S. M. F., additional, de Groot-Kruseman, H. A., additional, te Winkel, M. L., additional, Fiocco, M., additional, van den Akker, E. L. T., additional, Hoogerbrugge, P., additional, van den Berg, H., additional, Leeuw, J. A., additional, Bruin, M. C. A., additional, Bresters, D., additional, Veerman, A. J. P., additional, Pieters, R., additional, and van den Heuvel-Eibrink, M. M., additional

Published
2014
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18. Personalized medicine of methotrexate therapy

Author

Rotte, M. C. F. J., Den Boer, E., Bulatović Ćalasan, M., Heijstek, M. W., Te Winkel, M. L., Heil, S. G., Lindemans, J., Jansen, G., Godefridus J Peters, Kamphuis, S. S. M., Pieters, R., Tissing, W. J. E., Den Heuvel-Eibrink, M. M., Hazes, J. M. W., Wulffraat, N. M., and Jonge, R.

19. Germline variation in the MTHFR and MTRR genes determines the nadir of bone density in pediatric acute lymphoblastic leukemia: a prospective study.

Author

te Winkel ML, de Muinck Keizer-Schrama SM, de Jonge R, van Beek RD, van der Sluis IM, Hop WC, Pieters R, and van den Heuvel-Eibrink MM

Subjects
Absorptiometry, Photon, Adolescent, Biomarkers, Tumor genetics, Case-Control Studies, Child, Child, Preschool, Folic Acid metabolism, Fractures, Bone complications, Fractures, Bone genetics, Genotype, Homocysteine metabolism, Humans, Infant, Precursor Cell Lymphoblastic Leukemia-Lymphoma complications, Precursor Cell Lymphoblastic Leukemia-Lymphoma diagnostic imaging, Prospective Studies, Vitamin B 12 metabolism, Bone Density genetics, Ferredoxin-NADP Reductase genetics, Germ Cells metabolism, Methylenetetrahydrofolate Reductase (NADPH2) genetics, Polymorphism, Single Nucleotide genetics, Precursor Cell Lymphoblastic Leukemia-Lymphoma enzymology, Precursor Cell Lymphoblastic Leukemia-Lymphoma genetics
Abstract

Background: This study aims to identify folate-metabolism-related genetic risk factors for low bone mineral density (BMD) during/after pediatric acute lymphoblastic leukemia (ALL) treatment., Patients and Methods: We investigated the influence of methylenetetrahydrofolate reductase (MTHFR 677C > T and 1298A > C) and methionine synthase reductase (MTRR 66A > G) single nucleotide polymorphisms (SNPs) on total body BMD (BMD(TB)) and lumbar spine BMD (BMD(LS)) in 83 patients. Homocysteine, folate and vitamin B12 were determined. BMD was measured repeatedly using dual-energy X-ray absorptiometry in patients ≥ 4 years (n = 68)., Results: Carriers of the MTHFR 677 T-allele showed a lower baseline BMD(TB) than non-carriers (-0.38 SDS vs. +0.55 SDS, p = 0.01) and BMD(TB) remained lower during/after treatment. MTHFR 677C>T did not influence treatment-related loss of BMD(TB) (p = 0.39). The MTRR 66 G-allele carriers showed a trend towards a lower BMD(TB) compared with non-carriers. Combining these two SNPs, patients carrying ≥ 2 risk alleles had a significantly lower BMD(TB) (-1.40 SDS) than patients with one (-0.80 SDS) or no risk alleles (-0.31 SDS). Although carriers of the MTHFR 1298A > C had higher homocysteine levels, this SNP was not related to BMD(TB). BMD(LS) of carriers was similar to non-carriers of the investigated SNPs., Conclusions: The MTHFR 677C>T SNP and the MTRR 66A >G SNP were identified as determinants of impaired BMD(TB) in childhood ALL patients., (Crown Copyright © 2010. Published by Elsevier Inc. All rights reserved.)

Published
2011
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20. Letter to the editor in response to "Prospective bone ultrasound patterns during childhood acute lymphoblastic leukemia" by Mussa et al.

Author

te Winkel ML, van der Sluis IM, Lequin MH, Pieters R, and van den Heuvel-Eibrink MM

Subjects
Absorptiometry, Photon, Bone Density physiology, Bone Resorption complications, Bone Resorption diagnostic imaging, Bone and Bones pathology, Bone and Bones physiopathology, Child, Fractures, Bone complications, Fractures, Bone diagnostic imaging, Fractures, Bone pathology, Humans, Precursor Cell Lymphoblastic Leukemia-Lymphoma complications, Precursor Cell Lymphoblastic Leukemia-Lymphoma therapy, Prospective Studies, Reference Standards, Reproducibility of Results, Ultrasonography, Bone and Bones diagnostic imaging, Precursor Cell Lymphoblastic Leukemia-Lymphoma diagnostic imaging
Published
2010
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