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30 results on '"Tchamgoue, Joseph"'

5. LC-MS Identification and Preliminary Pharmacological Study of the Aqueous and Ethanol Extracts from Combretum glutinosum Perr ex DC. (Combretaceae)

Author

Toklo, Placide Mahougnan, Ahomadegbe, Mathias Amour, Dah-Nouvlessounon, Durand, Jouda, Jean-Bosco, Tchegnitegni, Billy Toussie, Wouamba, Steven Collins Njonte, Ahoton, Djidénou, Assogba, Mahoudo Fidèle, Tchamgoue, Joseph, Lenta, Bruno Ndjakou, Kouam, Simeon Fogue, Baba-Moussa, Lamine, Ladekan, Eléonore Chikani Yayi, and Gbenou, Joachim Djimon

Published
2023
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7. In Vitro and Molecular Docking Evaluation of the Anticholinesterase and Antidiabetic Effects of Compounds from Terminalia macroptera Guill. & Perr. (Combretaceae)

Author

Feunaing, Romeo Toko, primary, Tamfu, Alfred Ngenge, additional, Gbaweng, Abel Joel Yaya, additional, Kucukaydin, Selcuk, additional, Tchamgoue, Joseph, additional, Lannang, Alain Meli, additional, Lenta, Bruno Ndjakou, additional, Kouam, Simeon Fogue, additional, Duru, Mehmet Emin, additional, Anouar, El Hassane, additional, Talla, Emmanuel, additional, and Dinica, Rodica Mihaela, additional

Published
2024
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14. Potentiation effect of mallotojaponin B on chloramphenicol and mode of action of combinations against Methicillin-resistant Staphylococcus aureus

Author

Nguena-Dongue, Branly-Natalien, primary, Tchamgoue, Joseph, additional, Ngandjui Tchangoue, Yvan Anderson, additional, Lunga, Paul Keilah, additional, Toghueo, Kouipou Rufin Marie, additional, Zeuko`o, Menkem Elisabeth, additional, Melogmo, Yanick Kevin Dongmo, additional, Tchouankeu, Jean Claude, additional, Kouam, Simeon Fogue, additional, and Fekam, Boyom Fabrice, additional

Published
2023
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15. Polyoxygenated Stigmastane-Type Steroids from Vernonia kotschyana Sch. Bip. ex Walp. and Their Chemophenetic Significance

Author

Tseme Wandji, Nadine, Bitchagno, Gabin Thierry M., Mawabo Kamga, Isabelle, Tchamgoue, Joseph, Nkenfou, Celine Nguefeu, Lenta, Bruno Ndjakou, Sewald, Norbert, and Kouam, Simeon Fogue

Subjects
antibacterial activity, structure elucidation, Asteraceae, stigmastanes, chemophenetic significance, Vernonia kotschyana
Abstract

Four polyoxygenated stigmastanes (1–4) alongside known analogues (7–8) and flavonoids (5–6) were isolated from a dichloromethane/methanol (1:1, v/v) extract of the whole plant of Vernonia kotschyana Sch. Bip. ex Walp. (Asteraceae). Their structures were determined by means of spectroscopic and spectrometric analysis. The relative stereochemistry of the new compounds was established and confirmed via biosynthesis evidence and cyclization of 1 under acidic conditions. A plausible biosynthetic pathway to the new compounds and the chemophenetic significance of the isolated constituents were also discussed. The crude extract, fractions, and compounds (1–3) were assessed for their antibacterial activity against five highly prevalent bacterial strains. The fractions and compounds showed low to moderate activity with minimal inhibitory concentrations (MICs) > 125 µg/mL.

Published
2023

16. Atricephenols A and B, two phenolic compounds from Indigofera atriceps Hook.f. (Fabaceae).

Author

Mouafon, Iliassou Lah, Mountessou, Bel Youssouf Gbetnkom, Lateef, Mehreen, Tchamgoue, Joseph, Shaiq Ali, Muhammad, Tchouankeu, Jean Claude, Green, Ivan Robert, Ngadjui, Bonaventure Tchaleu, and Kouam, Simeon Fogue

Subjects
PHENOLS, INDIGOFERA, LEGUMES, METABOLITES, SALMONELLA typhi, THIOUREA
Abstract

The phytochemical investigation of a previously unstudied species of the genus Indigofera, I. atriceps Hook.f. was undertaken and two new phenolic compounds, atricephenols A (1) and B (2) were isolated, along with nine known secondary metabolites viz., (-)-melilotocarpan D (3), genistein (4), melilotocarpan A (5), maackiain (6), p-hydroxybenzaldehyde (7), bornesitol (8), β-sitosterol (9), sitosterol-3-O-β-D-glucopyranoside (10) and stigmasterol-3-O-β-D-glucopyranoside (11). Their structures were elucidated by extensive NMR spectroscopic analyses and HRESIMS, and by comparing their data with those reported in the literature. Compounds 1, 4, 7–11 were tested for their antibacterial efficacies and for their potential to inhibit the enzyme urease. Compounds 7 and 9 showed significant antibacterial activity against Salmonella typhi (ZOIs of 13 and 15 mm, respectively), while the best urease inhibition was measured for compound 9 with an IC50 value of 18.6 µM, which is higher than that of the potent inhibitor, thiourea (IC50 = 21.5 µM). [ABSTRACT FROM AUTHOR]

Published
2023
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21. Additional file 1 of Identification of 3,3′-O-dimethylellagic acid and apigenin as the main antiplasmodial constituents of Endodesmia calophylloides Benth and Hymenostegia afzelii (Oliver.) Harms

Author

Keumoe, Rodrigue, Koffi, Jean Garba, Dize, Darline, Fokou, Patrick Valère Tsouh, Tchamgoue, Joseph, Ayong, Lawrence, Ndjakou, Bruno Lenta, Sewald, Norbert, Ngameni, Bathelemy, and Boyom, Fabrice Fekam

Abstract

Additional file 1. 1. NMR data of apigenin (1). 2. NMR data of afzelechin (2). 3. NMR data of kaempferol (3). 4. NMR data of 2β,3β-dihydroxylup-20-ene (4). 5. NMR data of octacosanoic acid (5). 6. NMR data of 3,3′-O-dimethylellagic acid (6).

Published
2021
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22. Greenwaylactams A, B and C, the First Group of Sesquiterpene Alkaloids with an Eight‐Membered Lactam Ring from Greenwayodendron oliveri

Author

Kemgni, Mireille F., primary, Chenda, Laurice Bracine N., additional, Tchamgoue, Joseph, additional, Kenfack, Patrice T., additional, Ngandjui, Yvan Anderson T., additional, Wouamba, Steven C. N., additional, Tiani, Gesquière Laure M., additional, Green, Ivan R., additional, and Kouam, Simeon F., additional

Published
2021
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24. Antibacterial phloroglucinols derivatives from the leaves of Mallotus oppositifolius (Geisler) Müll. Arg. (Euphorbiaceae)

Author

Tchangoue, Yvan Anderson Ngandjui, primary, Tchamgoue, Joseph, additional, Lunga, Paul Keilah, additional, Knepper, Janosch, additional, Paltinean, Ramona, additional, Ibrom, Kerstin, additional, Crișan, Gianina, additional, Kouam, Simeon Fogue, additional, Ali, Muhammad Shaiq, additional, and Schulz, Stefan, additional

Published
2020
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29. Traditional Uses, Phytochemistry, Pharmacology, and Toxicology of Erigeron floribundus(Kunth) Sch. Bip.: A Review

Author

Tamdem Guetchueng, Stephanie, Tiwa Lontsi, Axel, Kopa Kowa, Theodora, Tchamgoue, Joseph, Tsabang, Nole, and Nnanga, Emmanuel Nga

Abstract

Erigeron floribundus (Kunth) Sch. Bip. is a reputed medicinal plant widespread all over the world and used traditionally in the treatment of several diseases and infections such as skin disorders, malaria, and gastrointestinal infections. The purpose of this review is to provide a comprehensive overview of traditional uses, phytochemistry, pharmacological activity, and toxicological profile of E. floribundus, and to direct further studies on aspects that have not yet been investigated in order to bring more scientific data for this plant and then give an opportunity for future exploitation in pharmaceutical industries. A meticulous and methodical analysis of the literature was conducted using various online scientific databases and all relevant abstracts and full text articles analyzed and included in the review. A wide range of traditional uses are cited in the literature with the plant mostly being used in African folk medicine for the treatment of malaria and skin diseases. Phytochemical investigations of E. floribundus have resulted in the isolation of several metabolites from different classes including acetylene-derivatives, phenolic compounds, triterpenoids, and steroids. Extracts and isolates from this species were reported to exhibit promising antimicrobial, anti-inflammatory, and analgesic properties. However, the plant has also demonstrated some toxicological activities and should be used with caution. Reported chemical and pharmacological investigations of E. floribundus support the traditional uses of this plant which deserves further attention for antimicrobial drug discovery. The in-depth study should be emphasized the in vitro and in vivo antimicrobial assessment of its extracts and isolated compounds.

Published
2023
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30. Sensitive Determination of C-Alkylated Flavonoids by HPLC-ESI-MS/MS Using Multiple Reaction Monitoring Approach: Pseudarthria hookeri as a Case Study.

Author

Faraz I, Ali A, Ul Haq F, Tchamgoue J, Kouam SF, Miana GA, and Musharraf SG

Subjects
Limit of Detection, Linear Models, Models, Chemical, Reproducibility of Results, Chromatography, High Pressure Liquid methods, Fabaceae chemistry, Flavonoids analysis, Plant Extracts chemistry, Tandem Mass Spectrometry methods
Abstract

One of the major problems with the formulation of herbal medicines is the quality control of plant material to ensure its efficacy and safety. Quality control of medicinal plants requires analysis of many bioactive compounds present in the plant. C-alkylated flavonoids are an important bioactive subclass of flavonoids. A simple, rapid, sensitive and selective method is presented here for the quantification of bioactive C-alkylated flavonoids. This is the first quantitative method for analysis of C-alkylated flavonoids based on the multiple reaction monitoring (MRM) approach so far. This study focuses on method development for quantification of bioactive C-alkylated flavonoids. Quantification of a total of five C-alkylated flavonoids was done employing the MRM approach on an HPLC-QqQ-MS instrument. LODs and LOQs for quantified flavonoids were in the range of 0.41-1.32 and 1.23-3.96 ng/mL, respectively. Linear calibration curves between 25 and 1500 ng/mL were obtained with the regression coefficients of ≥0.996. Accuracy (% bias) and precision (% RSD) of the analyses were found to be less than 5%. Developed HPLC-ESI-MS/MS can be employed as a quality control method of plant raw materials., (© The Author(s) 2019. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.)

Published
2020
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