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Objective: To find the changing radiological pattern of COVID-19 on HRCT chest in vaccinated patients. Study Design: Observational, cross-sectional study. Place and Duration of Study: Combined Military Hospital, Sialkot Pakistan, from Jan to Feb 2022. Methodology: All patients referred for High-resolution computed tomography (HRCT) chest were included. All participants underwent HRCT chest after recording the demographic data. Computed tomography (CT) images were reviewed by an experienced radiologist for pulmonary involvement and determining the computed tomography severity score, which ranged from 0-40 points. Results: A total of 90 patients were included in the study. The mean age was 35.8±13.2 years. The number of partially vaccinated, fully vaccinated patients, and those with booster doses were 10(11.1%), 62(68.9%) and 18(20%), respectively. Patients with normal or non-specific findings on HRCT were 74(82.2%), and those with findings suggestive of COVID-19 pneumonitis were 16 (17.8%). The mean CT severity score among positive cases was 4.69±8.01, while the most frequent pulmonary finding was ground glass opacities found in 11(68.8%) cases. Conclusion: Vaccination reduces the frequency and severity of pulmonary involvement in cases with breakthrough COVID-19 though the presentation of the disease and pattern of the pulmonary involvement does not show much change.

Objective: To assess the role of unenhanced multidetector computed tomography (CT) of kidneys, ureters and bladder (KUB) in the initial imaging of suspected acute renal colic. Study Design: Retrospective longitudinal study. Place and Duration of Study: Combined Military Hospital, Kharian Pakistan, from Jan 2020 to Jan 2021. Methodology: One hundred and thirty-eight cases of suspected acute renal colic underwent CT-KUB. The demographic,radiological, clinical, and follow-up data were recorded for each patient. Results: There were 88(51.8%) males and 82(48.2%) females in the present study, with a mean age of 50.86±18.57 years. Out of 170 patients, only 138(81.17%) were indicated with acute findings, whereas 32(18.82%) individuals showed no acute findings.The mean stone size was found to be 4.77±0.98mm. Most of the stones had a location near the pelvic brim (n=47; 34.15%). Conclusion: The use of CT KUB should be encouraged for the evaluation of renal colic. Keywords: Acute renal colic, Computed tomography (CT), Computed tomography of Kidneys, ureter and bladder (CT-KUB).

Polycystic ovary syndrome (PCOS) is an oligogenic condition, characterised by hyperandrogenism, ovulatory dysfunction and polycystic ovarian morphology. Previously, European and Han Chinese populations identified different susceptibility loci, of which ERBB4 (rs1351592) was strongly associated with PCOS. Our study aimed to investigate the association of ERBB4 Single Nucleotide Polymorphism (SNP), rs1351592 with PCOS in Pakistani women of Hazara region. Fifty PCOS patients and 14 healthy women were recruited and SNP was replicated using ARMS-PCR and sequencing. The study showed that Luteinising Hormone (LH), Follicle Stimulating Hormone (FSH), and Testosterone (T) were significantly elevated in patients compared to controls (P