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Objective: To determine the pattern of proton pump inhibitors (PPIs) use in medical wards. Study Design: Prospective observational study. Place and Duration of Study: Department of medical post graduate medical institute, study for 24 weeks, from 01 Nov 2014. Material and Methods: One thousand eight hundred consecutive patients admitted in medical wards and emergency department were enrolled and followed during hospital stay and their discharge slips were analyzed without intervention in the management protocol of different primary consultants. Results: Results were analyzed on SPSS version 20. Out of 1800 patients, 53.3% (n=960) were males and 46.7% (n=840) females, 72.6% (n=1306) had been prescribed PPIs. Major indications for the use of PPI were stress ulcer prophylaxis (32.5%), upper G.I bleeding (20.0%), acid peptic disease (12.5%), patients of GERD (8.1%) and NSAID use (7.5%). In 19.3% patients, indication of PPI use was not mentioned. Out of the admitted patients 57.7% patients were prescribed inject-able and 42.3% were given oral PPIs. There were 77.9% (n=1018) patients prescribed PPIs on discharge slips while duration of treatment and indication for their use were not mentioned on discharge slips for 66.3% (n=866) and 72.3% (n=944) patients, respectively. Conclusion: PPIs are over used without clear indications in hospitalized and discharged patients. [ABSTRACT FROM AUTHOR]