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10,868 results on '"Taylor, F"'

4. Rapamycin-encapsulated nanoparticle delivery in polycystic kidney disease mice

Author

Shinobu Yamaguchi, Randee Sedaka, Chintan Kapadia, Jifeng Huang, Jung-Shan Hsu, Taylor F. Berryhill, Landon Wilson, Stephen Barnes, Caleb Lovelady, Yasin Oduk, Ryan M. Williams, Edgar A. Jaimes, Daniel A. Heller, and Takamitsu Saigusa

Subjects
Medicine, Science
Abstract

Abstract Rapamycin slows cystogenesis in murine models of polycystic kidney disease (PKD) but failed in clinical trials, potentially due to insufficient drug dosing. To improve drug efficiency without increasing dose, kidney-specific drug delivery may be used. Mesoscale nanoparticles (MNP) selectively target the proximal tubules in rodents. We explored whether MNPs can target cystic kidney tubules and whether rapamycin-encapsulated-MNPs (RapaMNPs) can slow cyst growth in Pkd1 knockout (KO) mice. MNP was intravenously administered in adult Pkd1KO mice. Serum and organs were harvested after 8, 24, 48 or 72 h to measure MNP localization, mTOR levels, and rapamycin concentration. Pkd1KO mice were then injected bi-weekly for 6 weeks with RapaMNP, rapamycin, or vehicle to determine drug efficacy on kidney cyst growth. Single MNP injections lead to kidney-preferential accumulation over other organs, specifically in tubules and cysts. Likewise, one RapaMNP injection resulted in higher drug delivery to the kidney compared to the liver, and displayed sustained mTOR inhibition. Bi-weekly injections with RapaMNP, rapamycin or vehicle for 6 weeks resulted in inconsistent mTOR inhibition and little change in cyst index, however. MNPs serve as an effective short-term, kidney-specific delivery system, but long-term RapaMNP failed to slow cyst progression in Pkd1KO mice.

Published
2024
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5. Enhancing extracellular vesicle cargo loading and functional delivery by engineering protein-lipid interactions

Author

Justin A. Peruzzi, Taylor F. Gunnels, Hailey I. Edelstein, Peilong Lu, David Baker, Joshua N. Leonard, and Neha P. Kamat

Subjects
Science
Abstract

Abstract Naturally generated lipid nanoparticles termed extracellular vesicles (EVs) hold significant promise as engineerable therapeutic delivery vehicles. However, active loading of protein cargo into EVs in a manner that is useful for delivery remains a challenge. Here, we demonstrate that by rationally designing proteins to traffic to the plasma membrane and associate with lipid rafts, we can enhance loading of protein cargo into EVs for a set of structurally diverse transmembrane and peripheral membrane proteins. We then demonstrate the capacity of select lipid tags to mediate increased EV loading and functional delivery of an engineered transcription factor to modulate gene expression in target cells. We envision that this technology could be leveraged to develop new EV-based therapeutics that deliver a wide array of macromolecular cargo.

Published
2024
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6. Hydrophobic mismatch drives self-organization of designer proteins into synthetic membranes

Author

Justin A. Peruzzi, Jan Steinkühler, Timothy Q. Vu, Taylor F. Gunnels, Vivian T. Hu, Peilong Lu, David Baker, and Neha P. Kamat

Subjects
Science
Abstract

Abstract The organization of membrane proteins between and within membrane-bound compartments is critical to cellular function. Yet we lack approaches to regulate this organization in a range of membrane-based materials, such as engineered cells, exosomes, and liposomes. Uncovering and leveraging biophysical drivers of membrane protein organization to design membrane systems could greatly enhance the functionality of these materials. Towards this goal, we use de novo protein design, molecular dynamic simulations, and cell-free systems to explore how membrane-protein hydrophobic mismatch could be used to tune protein cotranslational integration and organization in synthetic lipid membranes. We find that membranes must deform to accommodate membrane-protein hydrophobic mismatch, which reduces the expression and co-translational insertion of membrane proteins into synthetic membranes. We use this principle to sort proteins both between and within membranes, thereby achieving one-pot assembly of vesicles with distinct functions and controlled split-protein assembly, respectively. Our results shed light on protein organization in biological membranes and provide a framework to design self-organizing membrane-based materials with applications such as artificial cells, biosensors, and therapeutic nanoparticles.

Published
2024
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8. Gigification of English Language Instructor Work in Higher Education: Precarious Employment and Magic Time

Author

Kouritzin, Sandra G., Ellis, Taylor F., Ghazani, Ahmad Zirak, and Nakagawa, Satoru

Abstract

This article describes how discourses of professionalism, insecurity, and exploitation among English as a second language/English for Academic Purposes (hereinafter ESL/EAP) instructors and curriculum-level administrators at two Canadian universities relate to their understanding of fair work. These understandings are examined in a nested manner, in keeping with social positioning theory. Via discourse and thematic analysis of job advertisements and semi-structured interviews, we illuminate aspects of the gigification of ESL/EAP in Canada, wherein ESL/EAP instructor work is increasingly rendered un(der)paid, constantly evaluated, surveilled, and precarious. Viewed through the lens of "magic time," an infinite category of work time, we document the frustrations of ESL/EAP instructors who recognize their own exploitation. The relevance of this study is described in relation to the growing numbers of international students at English-speaking universities throughout the world requiring a robust program infrastructure supporting their success, while the ESL/EAP instructors who provide these programs are increasingly made disposable through contingent employment relationships. The increasing reliance on contract professors teaching for-credit courses in higher education has come to be known as adjunctification. In the noncredit, the more marginal context of ESL/EAP instructors subject to the forces of international student supply and demand, underpaid even by contract faculty standards, and engaged in often cutthroat competition for the few remaining contracts, we reference contextual differences by calling it gigification.

Published
2023
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10. Spectral Aggregate of the High-Passed Fundamental Frequency and Its Relationship to the Primary Acoustic Features of Adductor Laryngeal Dystonia

Author

Marks, Katherine L., Feaster, Taylor F., Baker, Sarah, Díaz-Cádiz, Manuel E., Doyle, Philip C., and Stepp, Cara E.

Abstract

Objective: Currently, no clinically feasible objective measures exist that are specific to the signs of adductor laryngeal dystonia (LD), deterring effective diagnosis and treatment. This project sought to establish concurrent validity of a new automated acoustic outcome measure, designed to be specific to adductor laryngeal dystonia (AdLD): the spectral aggregate of the high-passed fundamental frequency contour (SAHfo). Method: Twenty speakers with AdLD read voiced phoneme-loaded (more symptomatic) and voiceless phoneme-loaded (less symptomatic) sentences. LD discontinuities (defined as phonatory breaks, frequency shifts, and creak), the acoustic ramifications of laryngeal spasms, were manually identified. The frequency content of the fo contour was examined as a function of time, and content above 1000 Hz was summed to automatically calculate SAHfo. Multiple linear regression analysis was applied to SAHfo based on LD discontinuities and sentence type (voiced or voiceless phoneme-loaded). Results: The regression model accounted for 41.1% of the variance in SAHfo. Both the LD discontinuities and sentence type were statistically related to SAHfo. Conclusion: Results of this study provide evidence of concurrent validity. SAHfo is an automatic outcome measure specific to acoustic signs of AdLD that may be useful to track treatment progress.

Published
2022
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12. Unusual Presentation of Craniopharyngioma Pituitary Mass in a 71-Year-Old Female: A Case Report

Author

Taylor F. Faust, Punuru Reddy, Jillian Weiss, Michael Steadman, Connie Morizio, and Garrett Cail

Subjects
Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract

In this report, we present the case of a 71-year-old African-American woman experiencing 2 months of intermittent headaches and episodes of blurred vision. Despite a comprehensive medical history that revealed chronic conditions and previous unrelated surgeries, the initial evaluation appeared to be unremarkable. Following the discovery of a mass on an imaging and a subsequent biopsy, the diagnosis of craniopharyngioma (WHO grade I) was confirmed. However, a brain mass was identified after additional ophthalmologic examination and MRI. This case explores the significance of recognizing atypical presentations of a brain injury that required a specific approach for diagnosis, surgical intervention and treatment, and postoperative care. This case contributes to the constantly evolving understanding of atypical manifestations of tumor characteristics and their complexities, along with the need to develop appropriate patient management strategies and provide optimal outcomes.

Published
2024
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13. Survival, healing, and swim performance of juvenile migratory sea lamprey (Petromyzon marinus) implanted with a new acoustic microtransmitter designed for small eel-like fishes

Author

Taylor F. Haas, Theodore Castro-Santos, Scott M. Miehls, Zhiqun D. Deng, Tyler M. Bruning, and C. Michael Wagner

Subjects
Lamprey, JSATS, ELATS, Acoustic Telemetry, Survival, Burst Swim, Ecology, QH540-549.5, Animal biochemistry, QP501-801
Abstract

Abstract Background Little is known about the transformer stage of the parasitic lampreys, a brief but critical period that encompasses juvenile out-migration from rivers to lakes or oceans to begin parasitic feeding. Information about this life stage could have significant conservation implications for both imperiled and invasive lampreys. We investigated tag retention, survival, wound healing, and swim performance of newly transformed sea lamprey (Petromyzon marinus) implanted with a new micro-acoustic transmitter, the eel–lamprey acoustic transmitter (ELAT), in a controlled laboratory environment. Results The 61-day survival of our tagged subjects was 71%, within the range reported in similar studies of juvenile lampreys. However, survival was significantly lower in the tagged animals (vs control), with no effect statistically attributable to measures of animal length, mass, condition, or population of origin (Great Lakes vs. Atlantic drainage). Mortality in tagged fish was concentrated in the first four days post-surgery, suggesting injury from the surgical process. An unusually long recovery time from anesthesia may have contributed to the increased mortality. In a simple burst swim assay, tagged animals swam significantly slower (− 22.5%) than untagged animals, but were not significantly different in endurance swim tests. A composite wound healing score at day four was a significant predictor of maximum burst swim speed at day 20, and wound condition was related to animal mass, but not length, at the time of tagging. Conclusions Impairments to survival and swim performance of juvenile sea lamprey implanted with the ELAT transmitter were within currently reported ranges for telemetry studies with small, difficult to observe fishes. Our results could be improved with more refined anesthesia and surgical techniques. The ability to track migratory movements of imperiled and pest populations of parasitic lampreys will improve our ability to estimate vital rates that underlie recruitment to the adult population (growth, survival) and to investigate the environmental factors that regulate the timing and rates of movement, in wild populations.

Published
2023
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14. Baseline 10-Year Cardiovascular Risk Scores Predict Cognitive Function in Older Persons, and Particularly Women, Living With Human Immunodeficiency Virus Infection

Author

Chow, Felicia C, Lyass, Asya, Mahoney, Taylor F, Massaro, Joseph M, Triant, Virginia A, Wu, Kunling, Berzins, Baiba, Robertson, Kevin, Ellis, Ronald J, Tassiopoulos, Katherine, Taiwo, Babafemi, and D’Agostino, Ralph B

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Prevention, Cardiovascular, Clinical Research, Aging, Behavioral and Social Science, Heart Disease, Good Health and Well Being, Aged, Aged, 80 and over, Cardiovascular Diseases, Cognition, Female, HIV Infections, Heart Disease Risk Factors, Humans, Male, Middle Aged, Risk Assessment, Risk Factors, HIV infection, cardiovascular risk, CVD, risk prediction, cognitive function, Biological Sciences, Medical and Health Sciences, Microbiology, Clinical sciences
Abstract

BackgroundCardiovascular disease (CVD) and associated comorbidities increase the risk of cognitive impairment in persons living with human immunodeficiency virus (PLWH). Given the potential composite effect of multiple cardiovascular risk factors on cognition, we examined the ability of the Atherosclerotic Cardiovascular Disease (ASCVD) risk score and the Framingham Heart Study Global CVD risk score (FRS) to predict future cognitive function in older PLWH.MethodsWe constructed linear regression models evaluating the association between baseline 10-year cardiovascular risk scores and cognitive function (measured by a summary z-score, the NPZ-4) at a year 4 follow-up visit.ResultsAmong 988 participants (mean age, 52 years; 20% women), mean 10-year ASCVD risk score at entry into the cohort was 6.8% (standard deviation [SD], 7.1%) and FRS was 13.1% (SD, 10.7%). In models adjusted only for cognitive function at entry, the ASCVD risk score significantly predicted year 4 NPZ-4 in the entire cohort and after stratification by sex (for every 1% higher ASCVD risk, year 4 NPZ-4 was lower by 0.84 [SD, 0.28] overall, P = .003; lower by 2.17 [SD, 0.67] in women, P = .001; lower by 0.78 [SD, 0.32] in men, P = .016). A similar relationship was observed between FRS and year 4 NPZ-4. In multivariable models, higher 10-year ASCVD risk and FRS predicted lower NPZ-4 in women.ConclusionsBaseline 10-year ASCVD risk and FRS predicted future cognitive function in older PLWH with well-controlled infection. Cardiovascular risk scores may help to identify PLWH, especially women, who are at risk for worse cognition over time.

Published
2020

16. Diurnal variation of dust and gas production in comet 67P/Churyumov-Gerasimenko at the inbound equinox as seen by OSIRIS and VIRTIS-M on board Rosetta

Author

Tubiana, C., Rinaldi, G., Güttler, C., Snodgrass, C., Shi, X., Hu, X., Marschall, R., Fulle, M., Bockelée-Morvan, D., Naletto, G., Capaccioni, F., Sierks, H., Arnold, G., Barucci, M. A., Bertaux, J. -L., Bertini, I., Bodewits, D., Capria, M. T., Ciarniello, M., Cremonese, G., Crovisier, J., Da Deppo, V., Debei, S., De Cecco, M., Deller, J., De Sanctis, M. C., Davidsson, B., Doose, L., Erard, S., Filacchione, G., Fink, U., Formisano, M., Fornasier, S., Gutiérrez, P. J., Ip, W. -H., Ivanovski, S., Kappel, D., Keller, H. U., Kolokolova, L., Koschny, D., Krueger, H., La Forgia, F., Lamy, P. L., Lara, L. M., Lazzarin, M., Levasseur-Regourd, A. C., Lin, Z. -Y., Longobardo, A., López-Moreno, J. J., Marzari, F., Migliorini, A., Mottola, S., Rodrigo, R., Taylor, F., Toth, I., and Zakharov, V.

Subjects
Astrophysics - Earth and Planetary Astrophysics
Abstract

On 27 Apr 2015, when 67P/C-G was at 1.76 au from the Sun and moving towards perihelion, the OSIRIS and VIRTIS-M instruments on Rosetta observed the evolving dust and gas coma during a complete rotation of the comet. We aim to characterize the dust, H2O and CO2 gas spatial distribution in the inner coma. To do this we performed a quantitative analysis of the release of dust and gas and compared the observed H2O production rate with the one calculated using a thermo-physical model. For this study we selected OSIRIS WAC images at 612 nm (dust) and VIRTIS-M image cubes at 612 nm, 2700 nm (H2O) and 4200 nm (CO2). We measured the average signal in a circular annulus, to study spatial variation around the comet, and in a sector of the annulus, to study temporal variation in the sunward direction with comet rotation, both at a fixed distance of 3.1 km from the comet centre. The spatial correlation between dust and water, both coming from the sun-lit side of the comet, shows that water is the main driver of dust activity in this time period. The spatial distribution of CO2 is not correlated with water and dust. There is no strong temporal correlation between the dust brightness and water production rate as the comet rotates. The dust brightness shows a peak at 0deg sub-solar longitude, which is not pronounced in the water production. At the same epoch, there is also a maximum in CO2 production. An excess of measured water production, with respect to the value calculated using a simple thermo-physical model, is observed when the head lobe and regions of the Southern hemisphere with strong seasonal variations are illuminated. A drastic decrease in dust production, when the water production (both measured and from the model) displays a maximum, happens when typical Northern consolidated regions are illuminated and the Southern hemisphere regions with strong seasonal variations are instead in shadow., Comment: 15 pages, accepted for publication in A&A

Published
2019
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17. VIRTIS-H observations of comet 67P's dust coma: spectral properties and color temperature variability with phase and elevation

Author

Bockelée-Morvan, D., Leyrat, C., Erard, S., Andrieu, F., Capaccioni, F., Filacchione, G., Hasselmann, P. H., Crovisier, J., Drossart, P., Arnold, G., Ciarniello, M., Kappel, D., Longobardo, A., Capria, M. -T., De Sanctis, M. C., Rinaldi, G., and Taylor, F.

Subjects
Astrophysics - Earth and Planetary Astrophysics
Abstract

We analyze 2-5 micrometre spectroscopic observations of the dust coma of comet 67P/Churyumov-Gerasimenko obtained with the VIRTIS-H instrument onboard Rosetta from 3 June to 29 October 2015 at heliocentric distances r_h = 1.24-1.55 AU. The 2-2.5 micrometre color, bolometric albedo, and color temperature are measured using spectral fitting. Data obtained at alpha = 90{\deg} solar phase angle show an increase of the bolometric albedo (0.05 to 0.14) with increasing altitude (0.5 to 8 km), accompanied by a possible marginal decrease of the color and color temperature. Possible explanations include the presence in the inner coma of dark particles on ballistic trajectories, and radial changes in particle composition. In the phase angle range 50-120{\deg}, phase reddening is significant (0.031 %/100 nm/{\deg}), for a mean color of 2 %/100 nm at alpha = 90{\deg}, that can be related to the roughness of the dust particles. Moreover, a decrease of the color temperature with decreasing phase angle is also observed at a rate of ~ 0.3 K/{\deg}, consistent with the presence of large porous particles, with low thermal inertia, and showing a significant day-to-night temperature contrast. Comparing data acquired at fixed phase angle (alpha = 90{\deg}), a 20% increase of the bolometric albedo is observed near perihelion. Heliocentric variations of the dust color are not significant in the analyzed time period. Measured color temperatures are varying from 260 to 320 K, and follow a r^0.6 variation in the r_h = 1.24-1.5 AU range, close to the expected r_h^0.5 value., Comment: 13 pages, 11 figures. Accepted for publication in Astronomy & Astrophysics

Published
2019
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19. Biodegradation of poly(butylene succinate) in soil laboratory incubations assessed by stable carbon isotope labelling

Author

Taylor F. Nelson, Rebekka Baumgartner, Madalina Jaggi, Stefano M. Bernasconi, Glauco Battagliarin, Carsten Sinkel, Andreas Künkel, Hans-Peter E. Kohler, Kristopher McNeill, and Michael Sander

Subjects
Science
Abstract

This study applies stable carbon isotope labelling to study polymer biodegradation in soils. This labelling enables accurate and precise tracking of polymer carbon during biodegradation and, thereby, provides a holistic picture of this process.

Published
2022
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20. Neoliberal Sleight of Hand in a University Strategic Plan: Weaponized Sustainability, Strategic Absences, and Magic Time

Author

Kouritzin, Sandra G., Nakagawa, Satoru, Kolomic, Erica, and Ellis, Taylor F.

Abstract

This research analyzed the University of Manitoba (UofM) Strategic Plan to both quantify the occurrence of specific keywords and make inferences about the purpose, messages, and effects being communicated by those keywords. In the first section of this paper, we provide an overview of the historical development and purpose of the neoliberal university. Second, we engage with content and critical discourse analysis to understand how academic work and academic identities are established by the strategic plan, a document that few faculty members consult regularly, and fewer still have a hand in developing. The foundational ideals of the UofM, cited at the beginning of the Strategic Plan are tracked through the document, and keywords as determined by frequency count are then similarly tracked. The findings reveal that most of the foundational ideals are not well-represented in the strategic plan; others, like sustainability, are euphemized. Keywords related to increasing workload are found over 60 times in the document, all in the context of decreased funding. We conclude that the strategic plan is a clear mandate for more to be completed with less. We refer to this aspect of workload creep as the need for "magic time."

Published
2021
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21. Evaluation of prognostic risk models for postoperative pulmonary complications in adult patients undergoing major abdominal surgery: a systematic review and international external validation cohort study

Author

Kouli, O, Murray, V, Bhatia, S, Cambridge, WA, Kawka, M, Shafi, S, Knight, SR, Kamarajah, SK, McLean, KA, Glasbey, JC, Khaw, RA, Ahmed, W, Akhbari, M, Baker, D, Borakati, A, Mills, E, Thavayogan, R, Yasin, I, Raubenheimer, K, Ridley, W, Sarrami, M, Zhang, G, Egoroff, N, Pockney, P, Richards, T, Bhangu, A, Creagh-Brown, B, Edwards, M, Harrison, EM, Lee, M, Nepogodiev, D, Pinkney, T, Pearse, R, Smart, N, Vohra, R, Sohrabi, C, Jamieson, A, Nguyen, M, Rahman, A, English, C, Tincknell, L, Kakodkar, P, Kwek, I, Punjabi, N, Burns, J, Varghese, S, Erotocritou, M, McGuckin, S, Vayalapra, S, Dominguez, E, Moneim, J, Salehi, M, Tan, HL, Yoong, A, Zhu, L, Seale, B, Nowinka, Z, Patel, N, Chrisp, B, Harris, J, Maleyko, I, Muneeb, F, Gough, M, James, CE, Skan, O, Chowdhury, A, Rebuffa, N, Khan, H, Down, B, Fatimah Hussain, Q, Adams, M, Bailey, A, Cullen, G, Fu, YXJ, McClement, B, Taylor, A, Aitken, S, Bachelet, B, Brousse de Gersigny, J, Chang, C, Khehra, B, Lahoud, N, Lee Solano, M, Louca, M, Rozenbroek, P, Rozitis, E, Agbinya, N, Anderson, E, Arwi, G, Barry, I, Batchelor, C, Chong, T, Choo, LY, Clark, L, Daniels, M, Goh, J, Handa, A, Hanna, J, Huynh, L, Jeon, A, Kanbour, A, Lee, A, Lee, J, Lee, T, Leigh, J, Ly, D, McGregor, F, Moss, J, Nejatian, M, O'Loughlin, E, Ramos, I, Sanchez, B, Shrivathsa, A, Sincari, A, Sobhi, S, Swart, R, Trimboli, J, Wignall, P, Bourke, E, Chong, A, Clayton, S, Dawson, A, Hardy, E, Iqbal, R, Le, L, Mao, S, Marinelli, I, Metcalfe, H, Panicker, D, R, HH, Ridgway, S, Tan, HH, Thong, S, Van, M, Woon, S, Woon-Shoo-Tong, XS, Yu, S, Ali, K, Chee, J, Chiu, C, Chow, YW, Duller, A, Nagappan, P, Ng, S, Selvanathan, M, Sheridan, C, Temple, M, Do, JE, Dudi-Venkata, NN, Humphries, E, Li, L, Mansour, LT, Massy-Westropp, C, Fang, B, Farbood, K, Hong, H, Huang, Y, Joan, M, Koh, C, Liu, YHA, Mahajan, T, Muller, E, Park, R, Tanudisastro, M, Wu, JJG, Chopra, P, Giang, S, Radcliffe, S, Thach, P, Wallace, D, Wilkes, A, Chinta, SH, Li, J, Phan, J, Rahman, F, Segaran, A, Shannon, J, Zhang, M, Adams, N, Bonte, A, Choudhry, A, Colterjohn, N, Croyle, JA, Donohue, J, Feighery, A, Keane, A, McNamara, D, Munir, K, Roche, D, Sabnani, R, Seligman, D, Sharma, S, Stickney, Z, Suchy, H, Tan, R, Yordi, S, Ahmed, I, Aranha, M, El Sabawy, D, Garwood, P, Harnett, M, Holohan, R, Howard, R, Kayyal, Y, Krakoski, N, Lupo, M, McGilberry, W, Nepon, H, Scoleri, Y, Urbina, C, Ahmad Fuad, MF, Ahmed, O, Jaswantlal, D, Kelly, E, Khan, MHT, Naidu, D, Neo, WX, O'Neill, R, Sugrue, M, Abbas, JD, Abdul-Fattah, S, Azlan, A, Barry, K, Idris, NS, Kaka, N, Mc Dermott, D, Mohammad Nasir, MN, Mozo, M, Rehal, A, Shaikh Yousef, M, Wong, RH, Curran, E, Gardner, M, Hogan, A, Julka, R, Lasser, G, Ní Chorráin, N, Ting, J, Browne, R, George, S, Janjua, Z, Leung Shing, V, Megally, M, Murphy, S, Ravenscroft, L, Vedadi, A, Vyas, V, Bryan, A, Sheikh, A, Ubhi, J, Vannelli, K, Vawda, A, Adeusi, L, Doherty, C, Fitzgerald, C, Gallagher, H, Gill, P, Hamza, H, Hogan, M, Kelly, S, Larry, J, Lynch, P, Mazeni, NA, O'Connell, R, O'Loghlin, R, Singh, K, Abbas Syed, R, Ali, A, Alkandari, B, Arnold, A, Arora, E, Azam, R, Breathnach, C, Cheema, J, Compton, M, Curran, S, Elliott, JA, Jayasamraj, O, Mohammed, N, Noone, A, Pal, A, Pandey, S, Quinn, P, Sheridan, R, Siew, L, Tan, EP, Tio, SW, Toh, VTR, Walsh, M, Yap, C, Yassa, J, Young, T, Agarwal, N, Almoosawy, SA, Bowen, K, Bruce, D, Connachan, R, Cook, A, Daniell, A, Elliott, M, Fung, HKF, Irving, A, Laurie, S, Lee, YJ, Lim, ZX, Maddineni, S, McClenaghan, RE, Muthuganesan, V, Ravichandran, P, Roberts, N, Shaji, S, Solt, S, Toshney, E, Arnold, C, Baker, O, Belais, F, Bojanic, C, Byrne, M, Chau, CYC, De Soysa, S, Eldridge, M, Fairey, M, Fearnhead, N, Guéroult, A, Ho, JSY, Joshi, K, Kadiyala, N, Khalid, S, Khan, F, Kumar, K, Lewis, E, Magee, J, Manetta-Jones, D, Mann, S, McKeown, L, Mitrofan, C, Mohamed, T, Monnickendam, A, Ng, AYKC, Ortu, A, Patel, M, Pope, T, Pressling, S, Purohit, K, Saji, S, Shah Foridi, J, Shah, R, Siddiqui, SS, Surman, K, Utukuri, M, Varghese, A, Williams, CYK, Yang, JJ, Billson, E, Cheah, E, Holmes, P, Hussain, S, Murdock, D, Nicholls, A, Patel, P, Ramana, G, Saleki, M, Spence, H, Thomas, D, Yu, C, Abousamra, M, Brown, C, Conti, I, Donnelly, A, Durand, M, French, N, Goan, R, O'Kane, E, Rubinchik, P, Gardiner, H, Kempf, B, Lai, YL, Matthews, H, Minford, E, Rafferty, C, Reid, C, Sheridan, N, Al Bahri, T, Bhoombla, N, Rao, BM, Titu, L, Chatha, S, Field, C, Gandhi, T, Gulati, R, Jha, R, Jones Sam, MT, Karim, S, Patel, R, Saunders, M, Sharma, K, Abid, S, Heath, E, Kurup, D, Patel, A, Ali, M, Cresswell, B, Felstead, D, Jennings, K, Kaluarachchi, T, Lazzereschi, L, Mayson, H, Miah, JE, Reinders, B, Rosser, A, Thomas, C, Williams, H, Al-Hamid, Z, Alsadoun, L, Chlubek, M, Fernando, P, Gaunt, E, Gercek, Y, Maniar, R, Ma, R, Matson, M, Moore, S, Morris, A, Nagappan, PG, Ratnayake, M, Rockall, L, Shallcross, O, Sinha, A, Tan, KE, Virdee, S, Wenlock, R, Donnelly, HA, Ghazal, R, Hughes, I, Liu, X, McFadden, M, Misbert, E, Mogey, P, O'Hara, A, Peace, C, Rainey, C, Raja, P, Salem, M, Salmon, J, Tan, CH, Alves, D, Bahl, S, Baker, C, Coulthurst, J, Koysombat, K, Linn, T, Rai, P, Sharma, A, Shergill, A, Ahmed, M, Ahmed, S, Belk, LH, Choudhry, H, Cummings, D, Dixon, Y, Dobinson, C, Edwards, J, Flint, J, Franco Da Silva, C, Gallie, R, Gardener, M, Glover, T, Greasley, M, Hatab, A, Howells, R, Hussey, T, Khan, A, Mann, A, Morrison, H, Ng, A, Osmond, R, Padmakumar, N, Pervaiz, F, Prince, R, Qureshi, A, Sawhney, R, Sigurdson, B, Stephenson, L, Vora, K, Zacken, A, Cope, P, Di Traglia, R, Ferarrio, I, Hackett, N, Healicon, R, Horseman, L, Lam, LI, Meerdink, M, Menham, D, Murphy, R, Nimmo, I, Ramaesh, A, Rees, J, Soame, R, Dilaver, N, Adebambo, D, Brown, E, Burt, J, Foster, K, Kaliyappan, L, Knight, P, Politis, A, Richardson, E, Townsend, J, Abdi, M, Ball, M, Easby, S, Gill, N, Ho, E, Iqbal, H, Matthews, M, Nubi, S, Nwokocha, JO, Okafor, I, Perry, G, Sinartio, B, Vanukuru, N, Walkley, D, Welch, T, Yates, 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T, Packham-Smith, A, Rowsell, K, Spector-Hill, I, Adeniken, E, Baker, J, Bartlett, M, Chikomba, L, Connell, B, Deekonda, P, Dhar, M, Elmansouri, A, Gamage, K, Goodhew, R, Hanna, P, Knight, J, Luca, A, Maasoumi, N, Mahamoud, F, Manji, S, Marwaha, PK, Mason, F, Oluboyede, A, Pigott, L, Razaq, AM, Richardson, M, Saddaoui, I, Wijeyendram, P, Yau, S, Atkins, W, Liang, K, Miles, N, Praveen, B, Ashai, S, Braganza, J, Common, J, Cundy, A, Davies, R, Guthrie, J, Handa, I, Iqbal, M, Ismail, R, Jones, C, Jones, I, Lee, KS, Levene, A, Okocha, M, Olivier, J, Smith, A, Subramaniam, E, Tandle, S, Wang, A, Watson, A, Wilson, C, Chan, XHF, Khoo, E, Montgomery, C, Norris, M, Pugalenthi, PP, Common, T, Cook, E, Mistry, H, Shinmar, HS, Agarwal, G, Bandyopadhyay, S, Brazier, B, Carroll, L, Goede, A, Harbourne, A, Lakhani, A, Lami, M, Larwood, J, Martin, J, Merchant, J, Pattenden, S, Pradhan, A, Raafat, N, Rothwell, E, Shammoon, Y, Sudarshan, R, Vickers, E, Wingfield, L, Ashworth, I, Azizi, S, Bhate, R, Chowdhury, T, Christou, A, Davies, L, Dwaraknath, M, Farah, Y, Garner, J, Gureviciute, E, Hart, E, Jain, A, Javid, S, Kankam, HK, Kaur Toor, P, Kaz, R, Kermali, M, Khan, I, Mattson, A, McManus, A, Murphy, M, Nair, K, Ngemoh, D, Norton, E, Olabiran, A, Parry, L, Payne, T, Pillai, K, Price, S, Punjabi, K, Raghunathan, A, Ramwell, A, Raza, M, Ritehnia, J, Simpson, G, Smith, W, Sodeinde, S, Studd, L, Subramaniam, M, Thomas, J, Towey, S, Tsang, E, Tuteja, D, Vasani, J, Vio, M, Badran, A, Adams, J, Anthony Wilkinson, J, Asvandi, S, Austin, T, Bald, A, Bix, E, Carrick, M, Chander, B, Chowdhury, S, Cooper Drake, B, Crosbie, S, D Portela, S, Francis, D, Gallagher, C, Gillespie, R, Gravett, H, Gupta, P, Ilyas, C, James, G, Johny, J, Jones, A, Kinder, F, MacLeod, C, Macrow, C, Maqsood-Shah, A, Mather, J, McCann, L, McMahon, R, Mitham, E, Mohamed, M, Munton, E, Nightingale, K, O'Neill, K, Onyemuchara, I, Senior, R, Shanahan, A, Sherlock, J, Spyridoulias, A, Stavrou, C, Stokes, D, Tamang, R, Taylor, E, Trafford, C, Uden, C, Waddington, C, Yassin, D, Zaman, M, Bangi, S, Cheng, T, Chew, D, Hussain, N, Imani-Masouleh, S, Mahasivam, G, McKnight, G, Ng, HL, Ota, HC, Pasha, T, Ravindran, W, Shah, K, Vishnu K, S, Zaman, S, Carr, W, Cope, S, Eagles, EJ, Howarth-Maddison, M, Li, CY, Reed, J, Ridge, A, Stubbs, T, Teasdaled, D, Umar, R, Worthington, J, Dhebri, A, Kalenderov, R, Alattas, A, Arain, Z, Bhudia, R, Chia, D, Daniel, S, Dar, T, Garland, H, Girish, M, Hampson, A, Kyriacou, H, Lehovsky, K, Mullins, W, Omorphos, N, Vasdev, N, Venkatesh, A, Waldock, W, Bhandari, A, Brown, G, Choa, G, Eichenauer, CE, Ezennia, K, Kidwai, Z, Lloyd-Thomas, A, Macaskill Stewart, A, Massardi, C, Sinclair, E, Skajaa, N, Smith, M, Tan, I, Afsheen, N, Anuar, A, Azam, Z, Bhatia, P, Davies-kelly, N, Dickinson, S, Elkawafi, M, Ganapathy, M, Gupta, S, Khoury, EG, Licudi, D, Mehta, V, Neequaye, S, Nita, G, Tay, VL, Zhao, S, Botsa, E, Cuthbert, H, Elliott, J, Furlepa, M, Lehmann, J, Mangtani, A, Narayan, A, Nazarian, S, Parmar, C, Shah, D, Shaw, C, Zhao, Z, Beck, C, Caldwell, S, Clements, JM, French, B, Kenny, R, Kirk, S, Lindsay, J, McClung, A, McLaughlin, N, Watson, S, Whiteside, E, Alyacoubi, S, Arumugam, V, Beg, R, Dawas, K, Garg, S, Lloyd, ER, Mahfouz, Y, Manobharath, N, Moonesinghe, R, Morka, N, Patel, K, Prashar, J, Yip, S, Adeeko, ES, Ajekigbe, F, Bhat, A, Evans, C, Farrugia, A, Gurung, C, Long, T, Malik, B, Manirajan, S, Newport, D, Rayer, J, Ridha, A, Ross, E, Saran, T, Sinker, A, Waruingi, D, Allen, R, Al Sadek, Y, Alves do Canto Brum, H, Asharaf, H, Ashman, M, Balakumar, V, Barrington, J, Baskaran, R, Berry, A, Bhachoo, H, Bilal, A, Boaden, L, Chia, WL, Covell, G, Crook, D, Dadnam, F, Davis, L, De Berker, H, Doyle, C, Fox, C, Gruffydd-Davies, M, Hafouda, Y, Hill, A, Hubbard, E, Hunter, A, Inpadhas, V, Jamshaid, M, Jandu, G, Jeyanthi, M, Jones, T, Kantor, C, Kwak, SY, Malik, N, Matt, R, McNulty, P, Miles, C, Mohomed, A, Myat, P, Niharika, J, Nixon, A, O'Reilly, D, Parmar, K, Pengelly, S, Price, L, Ramsden, M, Turnor, R, Wales, E, Waring, H, Wu, M, Yang, T, Ye, TTS, Zander, A, Zeicu, C, Bellam, S, Francombe, J, Kawamoto, N, Rahman, MR, Sathyanarayana, A, Tang, HT, Cheung, J, Hollingshead, J, Page, V, Sugarman, J, Wong, E, Chiong, J, Fung, E, Kan, SY, Kiang, J, Kok, J, Krahelski, O, Liew, MY, Lyell, B, Sharif, Z, Speake, D, Alim, L, Amakye, NY, Chandrasekaran, J, Chandratreya, N, Drake, J, Owoso, T, Thu, YM, Abou El Ela Bourquin, B, Alberts, J, Chapman, D, Rehnnuma, N, Ainsworth, K, Carpenter, H, Emmanuel, T, Fisher, T, Gabrel, M, Guan, Z, Hollows, S, Hotouras, A, Ip Fung Chun, N, Jaffer, S, Kallikas, G, Kennedy, N, Lewinsohn, B, Liu, FY, Mohammed, S, Rutherfurd, A, Situ, T, Stammer, A, Taylor, F, Thin, N, Urgesi, E, Zhang, N, Ahmad, MA, Bishop, A, Bowes, A, Dixit, A, Glasson, R, Hatta, S, Hatt, K, Larcombe, S, Preece, J, Riordan, E, Fegredo, D, Haq, MZ, Li, C, McCann, G, Stewart, D, Baraza, W, Bhullar, D, Burt, G, Coyle, J, Deans, J, Devine, A, Hird, R, Ikotun, O, Manchip, G, Ross, C, Storey, L, Tan, WWL, Tse, C, Warner, C, Whitehead, M, Wu, F, Court, EL, Crisp, E, Huttman, M, Mayes, F, Robertson, H, Rosen, H, Sandberg, C, Smith, H, Al Bakry, M, Ashwell, W, Bajaj, S, Bandyopadhyay, D, Browlee, O, Burway, S, Chand, CP, Elsayeh, K, Elsharkawi, A, Evans, E, Ferrin, S, Fort-Schaale, A, Iacob, M, I, K, Impelliziere Licastro, G, Mankoo, AS, Olaniyan, T, Otun, J, Pereira, R, Reddy, R, Saeed, D, Simmonds, O, Singhal, G, Tron, K, Wickstone, C, Williams, R, Bradshaw, E, De Kock Jewell, V, Houlden, C, Knight, C, Metezai, H, Mirza-Davies, A, Seymour, Z, Spink, D, and Wischhusen, S

Published
2022
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23. G protein-coupled receptor kinase 3 modulates mesenchymal stem cell proliferation and differentiation through sphingosine-1-phosphate receptor regulation

Author

Brozowski, Jaime M., Timoshchenko, Roman G., Serafin, D. Stephen, Allyn, Brittney, Koontz, Jessica, Rabjohns, Emily M., Rampersad, Rishi R., Ren, Yinshi, Eudy, Amanda M., Harris, Taylor F., Abraham, David, Mattox, Daniel, Rubin, Clinton T., Hilton, Matthew J., Rubin, Janet, Allbritton, Nancy L., Billard, Matthew J., and Tarrant, Teresa K.

Published
2022
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24. Optimizing pediatric tonsillectomy outcomes with an opioid sparing anesthesia protocol: Learning and continuously improving with real‐world data.

Author

Chiem, Jennifer L., Franz, Amber M., Hansen, Elizabeth E., Verma, Shilpa T., Stanzione, Taylor F., Bezzo, Leah K., Richards, Michael J., Parikh, Sanjay R., Dahl, John P., Low, Daniel K., and Martin, Lynn D.

Subjects
RECOVERY rooms, SURGICAL clinics, STATISTICAL process control, POSTOPERATIVE nausea & vomiting, SLEEP apnea syndromes, TONSILLECTOMY, PEDIATRIC anesthesia
Abstract

Introduction: This quality improvement initiative is a continued pursuit to optimize outcomes by iteratively improving our opioid sparing anesthesia protocol for tonsillectomy with or without adenoidectomy at our pediatric ambulatory surgical center through data driven Plan‐Do‐Study‐Act cycles. Methods: From 1/2015 through 12/2023, our standardized tonsillectomy protocol underwent nine procedure‐specific perioperative Plan‐Do‐Study‐Act cycles, three procedure‐specific postoperative prescription Plan‐Do‐Study‐Act cycles, and four general ambulatory surgical center enhanced recovery Plan‐Do‐Study‐Act cycles. We analyzed data from the medical record using statistical process control charts. The primary outcome measure was the percent of patients requiring intravenous opioid in the post anesthesia care unit. Secondary outcomes included maximum post anesthesia care unit pain score, the percent of patients requiring treatment for nausea and/or vomiting in the post anesthesia care unit, and the number of postoperative opioid prescription dosages. Balancing measures were average post anesthesia care unit length of stay, percent of patients with prolonged Post Anesthesia Care Unit length of stay (>120 min), and 30‐day reoperation rate. Results: A total of 5654 tonsillectomy with or without adenoidectomy cases were performed at our ambulatory surgical center from 2015 to 2023. The incidence of intravenous opioid administered in the post anesthesia care unit initially rose with opioid free anesthesia launch, but subsequently decreased below the target of 10%. Maximum post anesthesia care unit pain scores rose from mean 3.6 to 4.5, but subsequently returned to the baseline of 3.5, while the incidence of postoperative nausea and/or vomiting improved. The average post anesthesia care unit length of stay increased by 10 min with opioid free anesthesia; however, prolonged post anesthesia care unit stay and 30‐day reoperation rates were unchanged. Conclusions: The continued refinement of our opioid sparing anesthesia protocol has led to reduced perioperative and home opioid use, stable maximum post anesthesia care unit pain scores, and improved postoperative nausea and vomiting rates, with only a slight increase in mean post anesthesia care unit length of stay. [ABSTRACT FROM AUTHOR]

Published
2024
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25. Unusual Presentation of Craniopharyngioma Pituitary Mass in a 71‐Year‐Old Female: A Case Report.

Author

Faust, Taylor F., Reddy, Punuru, Weiss, Jillian, Steadman, Michael, Morizio, Connie, Cail, Garrett, and Isozaki, Osamu

Subjects
*SYMPTOMS, *POSTOPERATIVE care, *BRAIN injuries, *CHRONIC diseases, *DIAGNOSIS, *CRANIOPHARYNGIOMA
Abstract

In this report, we present the case of a 71‐year‐old African‐American woman experiencing 2 months of intermittent headaches and episodes of blurred vision. Despite a comprehensive medical history that revealed chronic conditions and previous unrelated surgeries, the initial evaluation appeared to be unremarkable. Following the discovery of a mass on an imaging and a subsequent biopsy, the diagnosis of craniopharyngioma (WHO grade I) was confirmed. However, a brain mass was identified after additional ophthalmologic examination and MRI. This case explores the significance of recognizing atypical presentations of a brain injury that required a specific approach for diagnosis, surgical intervention and treatment, and postoperative care. This case contributes to the constantly evolving understanding of atypical manifestations of tumor characteristics and their complexities, along with the need to develop appropriate patient management strategies and provide optimal outcomes. [ABSTRACT FROM AUTHOR]

Published
2024
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26. Drainage rearrangement in an intra-continental mountain belt: a case study from the central South Tian Shan, Kyrgyzstan.

Author

Gong, Lingxiao, van der Beek, Peter, Schildgen, Taylor F., Sobel, Edward R., Racano, Simone, Mariotti, Apolline, and McNab, Fergus

Subjects
WATERSHEDS, PETROLOGY, DRAINAGE, NEOGENE Period, INTEGRALS
Abstract

Fluvial drainage patterns in orogenic belts reflect interactions among tectonics, climate, and lithology. The central South Tian Shan displays a complex fluvial drainage pattern that shifts from longitudinal (flowing parallel to mountain ranges) in the west to transverse (flowing across ranges) in the east. Whether such drainage patterns reflect underlying patterns of tectonic deformation, lithology, climate, or the influence of surface processes within a drainage basin is often unclear. We focus here on the large Saryjaz catchment of SE Kyrgyzstan, which marks the transition between longitudinal and transverse drainages. We analyse topographic and fluvial metrics including slope, river steepness (ksn), and the integral proxy (χ) along the river profile, and we map the spatial distribution and characteristics of knickpoints to discern the possible controls on the observed drainage pattern. We discriminate between knickpoints of different origin, namely tectonic, lithologic, glacial, and those linked to transient waves of incision. We find a series of transient knickpoints in tributaries downstream of a sharp 180° bend in the main stem of the Saryjaz river, which also marks a striking increase in channel steepness. Both observations indicate accelerated incision along this lower reach of the catchment. Knickpoint elevations and ksn below the knickpoints decrease downstream, whereas χt values of knickpoints (χ measured from the tributary junctions) remain near-constant among tributaries. These results, together with a comparison of other rivers in the vicinity that show no evidence of transient knickpoints, suggest that transient incision in the Saryjaz catchment is driven "top-down" by a large-magnitude river capture event rather than "bottom-up" by accelerated uplift or base-level fall. We estimate an erodibility parameter from 10Be -derived catchment-average denudation rates and use this to estimate the celerity of knickpoints. We find that the knickpoints started retreating at a similar time between ca. 1.5 and 4.4 Myr ago. Considering the river patterns and the timing constraints, we suggest that this capture event was likely driven by the overfill of Neogene intermontane basins, potentially affected by both tectonic and climate factors. [ABSTRACT FROM AUTHOR]

Published
2024
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28. G protein-coupled receptor kinase 3 modulates mesenchymal stem cell proliferation and differentiation through sphingosine-1-phosphate receptor regulation

Author

Jaime M. Brozowski, Roman G. Timoshchenko, D. Stephen Serafin, Brittney Allyn, Jessica Koontz, Emily M. Rabjohns, Rishi R. Rampersad, Yinshi Ren, Amanda M. Eudy, Taylor F. Harris, David Abraham, Daniel Mattox, Clinton T. Rubin, Matthew J. Hilton, Janet Rubin, Nancy L. Allbritton, Matthew J. Billard, and Teresa K. Tarrant

Subjects
Bone marrow-derived mesenchymal stem cells, Mesenchymal stem cells, G protein-coupled receptors (GPCRs), G protein-coupled receptor kinase 3 (GRK3), Sphingosine-1-phosphate (S1P), Sphingosine-1-phosphate receptor (S1PR), Medicine (General), R5-920, Biochemistry, QD415-436
Abstract

Abstract Background The bone marrow niche supports hematopoietic cell development through intimate contact with multipotent stromal mesenchymal stem cells; however, the intracellular signaling, function, and regulation of such supportive niche cells are still being defined. Our study was designed to understand how G protein receptor kinase 3 (GRK3) affects bone marrow mesenchymal stem cell function by examining primary cells from GRK3-deficient mice, which we have previously published to have a hypercellular bone marrow and leukocytosis through negative regulation of CXCL12/CXCR4 signaling. Methods Murine GRK3-deficient bone marrow mesenchymal stromal cells were harvested and cultured to differentiate into three lineages (adipocyte, chondrocyte, and osteoblast) to confirm multipotency and compared to wild type cells. Immunoblotting, modified-TANGO experiments, and flow cytometry were used to further examine the effects of GRK3 deficiency on bone marrow mesenchymal stromal cell receptor signaling. Microcomputed tomography was used to determine trabecular and cortical bone composition of GRK3-deficient mice and standard ELISA to quantitate CXCL12 production from cellular cultures. Results GRK3-deficient, bone marrow-derived mesenchymal stem cells exhibit enhanced and earlier osteogenic differentiation in vitro. The addition of a sphingosine kinase inhibitor abrogated the osteogenic proliferation and differentiation, suggesting that sphingosine-1-phosphate receptor signaling was a putative G protein-coupled receptor regulated by GRK3. Immunoblotting showed prolonged ERK1/2 signaling after stimulation with sphingosine-1-phosphate in GRK3-deficient cells, and modified-TANGO assays suggested the involvement of β-arrestin-2 in sphingosine-1-phosphate receptor internalization. Conclusions Our work suggests that GRK3 regulates sphingosine-1-phosphate receptor signaling on bone marrow mesenchymal stem cells by recruiting β-arrestin to the occupied GPCR to promote internalization, and lack of such regulation affects mesenchymal stem cell functionality.

Published
2022
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40. Individual and joint associations of daily sleep and stress with daily well-being in hospital nurses: an ecological momentary assessment and actigraphy study

Author

Vigoureux, Taylor F. D. and Lee, Soomi

Subjects
Nurses -- Health aspects -- Psychological aspects, Stress (Psychology) -- Health aspects, Sleep -- Health aspects -- Psychological aspects, Psychology and mental health
Abstract

Sleep and stress are predictors of daily physical and emotional well-being, but few studies assess both simultaneously. This study examined individual and joint associations of daily sleep and stress with daily well-being (DWB) in hospital nurses. Nurses (n = 60) participated in a 14-day ecological momentary assessment and actigraphy study. Multilevel modeling revealed associations of stressor severity and poor sleep health with DWB, independent of and coupled with each other, at within- and between-person levels. Greater stressor severity or poorer sleep health, independent of each other, were associated with more physical symptoms, less positive affect (PA), and more negative affect (NA). Joint associations of stress and sleep with DWB were observed: PA was lowest when higher stressor severity was coupled with poorer sleep health; NA was lowest when lower stressor severity was coupled with better sleep health. Findings suggest the importance of considering both sleep and stress for DWB in hospital nurses., Author(s): Taylor F. D. Vigoureux [sup.1] , Soomi Lee [sup.1] Author Affiliations: (1) grid.170693.a, 0000 0001 2353 285X, School of Aging Studies, University of South Florida, , 4202 E. Fowler [...]

Published
2021
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45. Multi-hazard interrelationships and dynamic risk scenarios in urban areas: a case of Nairobi and Istanbul

Author

Sakic Trogrlic, R., Thompson, H., Mentese, E., Hussain, E., Gill, J., Taylor, F., Mwangi, E., Öner, E., Bukachi, V., Malamud, B., Sakic Trogrlic, R., Thompson, H., Mentese, E., Hussain, E., Gill, J., Taylor, F., Mwangi, E., Öner, E., Bukachi, V., and Malamud, B.

Abstract

This paper introduces a methodology for characterizing the breadth of natural hazard types, hazard interrelationships, and risk scenarios in Global South urban areas, focusing on Nairobi, Kenya, and Istanbul, Türkiye. Our approach involves (a) a comprehensive characterization of multi-hazards and their interrelationships in an urban setting, (b) collaborative development of relevant multi-hazard scenarios with local disaster risk reduction (DRR) stakeholders, and (c) analysis of the potential for integrating these scenarios into urban DRR efforts. Using a critical review of 135 sources (academic and gray literature, databases, online, and social media), we identify 19 natural hazard types that might influence Nairobi and 23 in Istanbul. We further identified in Nairobi 88 and Istanbul 105 hazard interrelationship pairs (e.g., an earthquake triggering landslides) out of a possible 576 interrelationships. These findings are cataloged in an extensive database, which informs the creation of multi-hazard risk scenario exemplars for each city. These exemplars are refined through stakeholder engagement, involving four workshops (47 participants) and nine semi-structured interviews with local DRR stakeholders. Despite the identified benefits, this engagement reveals a significant gap in integrating multi-hazards into current urban policy and practice. Governance challenges are highlighted as a key barrier, but opportunities for better integration are also identified, including evolving policies and growing awareness among urban actors. Our approach, particularly relevant in data-scarce urban areas of low- and middle-income countries, provides a framework for exploring multi-hazard issues in various urban contexts.

Published
2024

46. Latency measurement in functional analysis and treatment of behaviors targeted for reduction.

Author

Mattson, Stephanie L., Spinks, Hailey M., Joslyn, P. Raymond, Spinks, Elissa M., and Moore, Taylor F.

Subjects
FUNCTIONAL assessment, SYSTEMATIC reviews, HEALTH behavior, BEHAVIOR therapy
Abstract

Research has demonstrated that latency is a reasonable index of response strength in the functional analysis and treatment of behaviors targeted for reduction. The literature contains numerous examples of functional analyses emphasizing latency informing effective treatment for problem behavior in various scenarios. Latency measurement can improve the versatility of functional analyses by allowing researchers and practitioners to examine behaviors that are not amenable to a traditional functional analysis arrangement and conduct assessments in challenging environments. Although there have been several reviews of the functional analysis literature, to date none have specifically addressed functional analyses emphasizing latency measurement. Given the unique advantages of latency‐based functional analyses, a systematic review could be beneficial to researchers and practitioners in behavior analysis. Therefore, we conducted a systematic literature review of research on functional analyses using latency to measure target behaviors. Our review included 79 cases across 27 empirical research articles. We present a summary of the extant literature, highlight strengths and limitations of the empirical foundations, provide clinical implications, and discuss future directions for research. [ABSTRACT FROM AUTHOR]

Published
2024
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48. Deep convolutional neural networks to predict cardiovascular risk from computed tomography

Author

Roman Zeleznik, Borek Foldyna, Parastou Eslami, Jakob Weiss, Ivanov Alexander, Jana Taron, Chintan Parmar, Raza M. Alvi, Dahlia Banerji, Mio Uno, Yasuka Kikuchi, Julia Karady, Lili Zhang, Jan-Erik Scholtz, Thomas Mayrhofer, Asya Lyass, Taylor F. Mahoney, Joseph M. Massaro, Ramachandran S. Vasan, Pamela S. Douglas, Udo Hoffmann, Michael T. Lu, and Hugo J. W. L. Aerts

Subjects
Science
Abstract

Coronary artery calcium is an accurate predictor of cardiovascular events but this information is not routinely quantified. Here the authors show a robust and time-efficient deep learning system to automatically quantify coronary calcium on CT scans and predict cardiovascular events in a large, multicentre study.

Published
2021
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