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8. Cover

Author

Taylor, Amy Murrell

Published
2005

14. Introduction

Author

Taylor, Amy Murrell

Published
2005

17. Bibliography

Author

Taylor, Amy Murrell

Published
2005

20. Epilogue

Author

Taylor, Amy Murrell

Published
2005

22. Notes

Author

Taylor, Amy Murrell

Published
2005

23. Pelvic Venous Disorders

Author

Clark, Meghan R., Taylor, Amy C., Keefe, Nicole A., editor, Haskal, Ziv J.J, editor, Park, Auh Whan, editor, and Angle, John F., editor

Published
2024
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24. A platform-independent AI tumor lineage and site (ATLAS) classifier

Author

Rydzewski, Nicholas R., Shi, Yue, Li, Chenxuan, Chrostek, Matthew R., Bakhtiar, Hamza, Helzer, Kyle T., Bootsma, Matthew L., Berg, Tracy J., Harari, Paul M., Floberg, John M., Blitzer, Grace C., Kosoff, David, Taylor, Amy K., Sharifi, Marina N., Yu, Menggang, Lang, Joshua M., Patel, Krishnan R., Citrin, Deborah E., Sundling, Kaitlin E., and Zhao, Shuang G.

Published
2024
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31. The All of Us Research Program: Data quality, utility, and diversity

Author

Ramirez, Andrea H, Sulieman, Lina, Schlueter, David J, Halvorson, Alese, Qian, Jun, Ratsimbazafy, Francis, Loperena, Roxana, Mayo, Kelsey, Basford, Melissa, Deflaux, Nicole, Muthuraman, Karthik N, Natarajan, Karthik, Kho, Abel, Xu, Hua, Wilkins, Consuelo, Anton-Culver, Hoda, Boerwinkle, Eric, Cicek, Mine, Clark, Cheryl R, Cohn, Elizabeth, Ohno-Machado, Lucila, Schully, Sheri D, Ahmedani, Brian K, Argos, Maria, Cronin, Robert M, O’Donnell, Christopher, Fouad, Mona, Goldstein, David B, Greenland, Philip, Hebbring, Scott J, Karlson, Elizabeth W, Khatri, Parinda, Korf, Bruce, Smoller, Jordan W, Sodeke, Stephen, Wilbanks, John, Hentges, Justin, Mockrin, Stephen, Lunt, Christopher, Devaney, Stephanie A, Gebo, Kelly, Denny, Joshua C, Carroll, Robert J, Glazer, David, Harris, Paul A, Hripcsak, George, Philippakis, Anthony, Roden, Dan M, Program, the All of Us Research, Ahmedani, Brian, Johnson, Christine D Cole, Ahsan, Habib, Antoine-LaVigne, Donna, Singleton, Glendora, Topol, Eric, Baca-Motes, Katie, Steinhubl, Steven, Wade, James, Begale, Mark, Jain, Praduman, Sutherland, Scott, Lewis, Beth, Behringer, Melissa, Gharavi, Ali G, Bier, Louise, Brilliant, Murray H, Murali, Narayana, Hebbring, Scott Joseph, Farrar-Edwards, Dorothy, Burnside, Elizabeth, Drezner, Marc K, Taylor, Amy, Channamsetty, Veena, Montalvo, Wanda, Sharma, Yashoda, Chinea, Carmen, Jenks, Nancy, Thibodeau, Steve, Holmes, Beverly Wilson, Schlueter, Eric, Collier, Ever, Winkler, Joyce, Corcoran, John, D’Addezio, Nick, Daviglus, Martha, Winn, Robert, Roden, Dan, Denny, Joshua, Doheny, Kim, Nickerson, Debbie, Eichler, Evan, Jarvik, Gail, and Funk, Gretchen

Subjects
Networking and Information Technology R&D (NITRD), Clinical Research, Cardiovascular, Cancer, Generic health relevance, Good Health and Well Being, All of Us Research Program, cloud-based analytics, cohort study, electronic health records, precision medicine
Abstract

The All of Us Research Program seeks to engage at least one million diverse participants to advance precision medicine and improve human health. We describe here the cloud-based Researcher Workbench that uses a data passport model to democratize access to analytical tools and participant information including survey, physical measurement, and electronic health record (EHR) data. We also present validation study findings for several common complex diseases to demonstrate use of this novel platform in 315,000 participants, 78% of whom are from groups historically underrepresented in biomedical research, including 49% self-reporting non-White races. Replication findings include medication usage pattern differences by race in depression and type 2 diabetes, validation of known cancer associations with smoking, and calculation of cardiovascular risk scores by reported race effects. The cloud-based Researcher Workbench represents an important advance in enabling secure access for a broad range of researchers to this large resource and analytical tools.

Published
2022

34. ASO Visual Abstract: Association of Neighborhood Disadvantage with Short- and Long-Term Outcomes After Pancreatectomy for Pancreatic Ductal Adenocarcinoma

Author

Marcinak, Clayton T., Praska, Corinne E., Vidri, Roberto J., Taylor, Amy K., Krebsbach, John K., Ahmed, Kaleem S., LoConte, Noelle K., Varley, Patrick R., Afshar, Majid, Weber, Sharon M., Abbott, Daniel E., Mathew, Jomol, Murtaza, Muhammed, Burkard, Mark E., Churpek, Matthew M., and Zafar, Syed Nabeel

Published
2024
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40. Kinship

Author

Taylor, Amy

Published
2010

44. Phases of the Moon: As Simple as ABCDE Teaching the Phases of the Moon to First Graders Using Patterns

Author

Blum, Caleigh and Taylor, Amy

Abstract

Children are very curious about the world around them. You may find them peering at tadpoles in a pond, counting ants on a log, or wondering about the stars, the sun, and the moon. I have been asked many times: Is the moon really made of cheese? Do astronauts live on the moon? Why does the moon look different every time I look up? Introducing young learners to our universe, beyond what their eyes can see, is a powerful teaching moment that primary teachers like myself get the pleasure to experience. Fostering students' early curiosities regarding our universe is one of the first steps to opening their minds to the vision of endless possibilities. Making observations, asking questions, and recognizing patterns are a few of the initial skills a young science learner should be encouraged to practice. In this particular unit, first grade students make observations of the sky including the differences in features and apparent movement of celestial objects. This unit and the featured lesson emphasize the use of students' prior knowledge and observations of the sky and identifying patterns to predict and infer how the moon changes during the lunar cycle.

Published
2022
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48. Defining compassion and compassionate behaviours in radiotherapy

Author

Taylor, Amy Victoria, Appleyard, Robert, Hodgson, Denyse, Burton, Maria, Collins, Karen, and Probst, Heidi

Abstract

Inadequate care and compassionate practice have been blamed for failings within the NHS. UK healthcare legislation can be criticised for its failure to provide meaning or clarity of practical compassionate care. Consequently, hindering the ability of NHS Trusts, service delivery managers and employees to interpret and implement policy recommendations regarding compassionate practice at a local level. To support the implementation of compassionate legislation, the study sought to understand the perspectives of those in receipt and those delivering compassionate practice. The research aimed to co-construct a context specific definition of compassion and identify commonly recognised compassionate behaviours. Co-production underpinned the qualitative methodological inquiry and design of the research. Eleven focus groups were conducted, five with therapeutic radiographers, three with cancer patients and carers and three with student therapeutic radiographers. On completion of thematic analysis from those groups, three co-production workshops were conducted, integrating the data to ensure the co-produced findings were equally representative of the perspectives of the three participant groups. The co-produced definition conveys how compassion can be recognised by the intention to help, achieved through recognition of individuality and a tailored approach to meet the person's individual need. An understanding of compassionate display is illustrated through the construction of a conceptual framework. The findings indicate four components are essential for compassion demonstration and perception of compassionate display: 1) attitude, 2) behaviours, 3) understanding individuality and the appreciation of needs and 4) practices. Collectively these four components enable the therapeutic radiographer to behave in a manner which facilitates a connection with the patient whilst denoting their intent to be compassionate. Consequently, expression of intent enables the patient to perceive the practices as compassionate. This co-produced definition, underpinned by a conceptual understanding of compassionate display, will facilitate the translation of policy into practice. Recommendations are made which aim to equip the profession with therapeutic radiographers that hold intent to be compassionate, are motivated and have both the confidence and opportunity to be compassionate in a supported culture which shares the vision for person-centred compassionate care. Consequently, this should improve the quality of compassionate care received by patients.

Published
2020

49. Genetic diversity fuels gene discovery for tobacco and alcohol use

Author

Saunders, Gretchen R. B., Wang, Xingyan, Chen, Fang, Jang, Seon-Kyeong, Liu, Mengzhen, Wang, Chen, Gao, Shuang, Jiang, Yu, Khunsriraksakul, Chachrit, Otto, Jacqueline M., Addison, Clifton, Akiyama, Masato, Albert, Christine M., Aliev, Fazil, Alonso, Alvaro, Arnett, Donna K., Ashley-Koch, Allison E., Ashrani, Aneel A., Barnes, Kathleen C., Barr, R. Graham, Bartz, Traci M., Becker, Diane M., Bielak, Lawrence F., Benjamin, Emelia J., Bis, Joshua C., Bjornsdottir, Gyda, Blangero, John, Bleecker, Eugene R., Boardman, Jason D., Boerwinkle, Eric, Boomsma, Dorret I., Boorgula, Meher Preethi, Bowden, Donald W., Brody, Jennifer A., Cade, Brian E., Chasman, Daniel I., Chavan, Sameer, Chen, Yii-Der Ida, Chen, Zhengming, Cheng, Iona, Cho, Michael H., Choquet, Hélène, Cole, John W., Cornelis, Marilyn C., Cucca, Francesco, Curran, Joanne E., de Andrade, Mariza, Dick, Danielle M., Docherty, Anna R., Duggirala, Ravindranath, Eaton, Charles B., Ehringer, Marissa A., Esko, Tõnu, Faul, Jessica D., Silva, Lilian Fernandes, Fiorillo, Edoardo, Fornage, Myriam, Freedman, Barry I., Gabrielsen, Maiken E., Garrett, Melanie E., Gharib, Sina A., Gieger, Christian, Gillespie, Nathan, Glahn, David C., Gordon, Scott D., Gu, Charles C., Gu, Dongfeng, Gudbjartsson, Daniel F., Guo, Xiuqing, Haessler, Jeffrey, Hall, Michael E., Haller, Toomas, Harris, Kathleen Mullan, He, Jiang, Herd, Pamela, Hewitt, John K., Hickie, Ian, Hidalgo, Bertha, Hokanson, John E., Hopfer, Christian, Hottenga, JoukeJan, Hou, Lifang, Huang, Hongyan, Hung, Yi-Jen, Hunter, David J., Hveem, Kristian, Hwang, Shih-Jen, Hwu, Chii-Min, Iacono, William, Irvin, Marguerite R., Jee, Yon Ho, Johnson, Eric O., Joo, Yoonjung Y., Jorgenson, Eric, Justice, Anne E., Kamatani, Yoichiro, Kaplan, Robert C., Kaprio, Jaakko, Kardia, Sharon L. R., Keller, Matthew C., Kelly, Tanika N., Kooperberg, Charles, Korhonen, Tellervo, Kraft, Peter, Krauter, Kenneth, Kuusisto, Johanna, Laakso, Markku, Lasky-Su, Jessica, Lee, Wen-Jane, Lee, James J., Levy, Daniel, Li, Liming, Li, Kevin, Li, Yuqing, Lin, Kuang, Lind, Penelope A., Liu, Chunyu, Lloyd-Jones, Donald M., Lutz, Sharon M., Ma, Jiantao, Mägi, Reedik, Manichaikul, Ani, Martin, Nicholas G., Mathur, Ravi, Matoba, Nana, McArdle, Patrick F., McGue, Matt, McQueen, Matthew B., Medland, Sarah E., Metspalu, Andres, Meyers, Deborah A., Millwood, Iona Y., Mitchell, Braxton D., Mohlke, Karen L., Moll, Matthew, Montasser, May E., Morrison, Alanna C., Mulas, Antonella, Nielsen, Jonas B., North, Kari E., Oelsner, Elizabeth C., Okada, Yukinori, Orrù, Valeria, Palmer, Nicholette D., Palviainen, Teemu, Pandit, Anita, Park, S. Lani, Peters, Ulrike, Peters, Annette, Peyser, Patricia A., Polderman, Tinca J. C., Rafaels, Nicholas, Redline, Susan, Reed, Robert M., Reiner, Alex P., Rice, John P., Rich, Stephen S., Richmond, Nicole E., Roan, Carol, Rotter, Jerome I., Rueschman, Michael N., Runarsdottir, Valgerdur, Saccone, Nancy L., Schwartz, David A., Shadyab, Aladdin H., Shi, Jingchunzi, Shringarpure, Suyash S., Sicinski, Kamil, Skogholt, Anne Heidi, Smith, Jennifer A., Smith, Nicholas L., Sotoodehnia, Nona, Stallings, Michael C., Stefansson, Hreinn, Stefansson, Kari, Stitzel, Jerry A., Sun, Xiao, Syed, Moin, Tal-Singer, Ruth, Taylor, Amy E., Taylor, Kent D., Telen, Marilyn J., Thai, Khanh K., Tiwari, Hemant, Turman, Constance, Tyrfingsson, Thorarinn, Wall, Tamara L., Walters, Robin G., Weir, David R., Weiss, Scott T., White, Wendy B., Whitfield, John B., Wiggins, Kerri L., Willemsen, Gonneke, Willer, Cristen J., Winsvold, Bendik S., Xu, Huichun, Yanek, Lisa R., Yin, Jie, Young, Kristin L., Young, Kendra A., Yu, Bing, Zhao, Wei, Zhou, Wei, Zöllner, Sebastian, Zuccolo, Luisa, Batini, Chiara, Bergen, Andrew W., Bierut, Laura J., David, Sean P., Gagliano Taliun, Sarah A., Hancock, Dana B., Jiang, Bibo, Munafò, Marcus R., Thorgeirsson, Thorgeir E., Liu, Dajiang J., and Vrieze, Scott

Published
2022
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50. Reduced C9ORF72 function exacerbates gain of toxicity from ALS/FTD-causing repeat expansion in C9orf72

Author

Zhu, Qiang, Jiang, Jie, Gendron, Tania F, McAlonis-Downes, Melissa, Jiang, Lulin, Taylor, Amy, Diaz Garcia, Sandra, Ghosh Dastidar, Somasish, Rodriguez, Maria J, King, Patrick, Zhang, Yongjie, La Spada, Albert R, Xu, Huaxi, Petrucelli, Leonard, Ravits, John, Da Cruz, Sandrine, Lagier-Tourenne, Clotilde, and Cleveland, Don W

Subjects
Genetics, Neurosciences, Neurodegenerative, Aging, Orphan Drug, Dementia, Rare Diseases, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Brain Disorders, Alzheimer's Disease Related Dementias (ADRD), Frontotemporal Dementia (FTD), ALS, Acquired Cognitive Impairment, 2.1 Biological and endogenous factors, Aetiology, Neurological, Amyotrophic Lateral Sclerosis, Animals, C9orf72 Protein, DNA Repeat Expansion, Female, Frontotemporal Dementia, Male, Mice, Mice, Inbred C57BL, Mice, Transgenic, Psychology, Cognitive Sciences, Neurology & Neurosurgery
Abstract

Hexanucleotide expansions in C9orf72, which encodes a predicted guanine exchange factor, are the most frequent genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Although repeat expansion has been established to generate toxic products, mRNAs encoding the C9ORF72 protein are also reduced in affected individuals. In this study, we tested how C9ORF72 protein levels affected repeat-mediated toxicity. In somatic transgenic mice expressing 66 GGGGCC repeats, inactivation of one or both endogenous C9orf72 alleles provoked or accelerated, respectively, early death. In mice expressing a C9orf72 transgene with 450 repeats that did not encode the C9ORF72 protein, inactivation of one or both endogenous C9orf72 alleles exacerbated cognitive deficits, hippocampal neuron loss, glial activation and accumulation of dipeptide-repeat proteins from translation of repeat-containing RNAs. Reduced C9ORF72 was shown to suppress repeat-mediated elevation in autophagy. These efforts support a disease mechanism in ALS/FTD resulting from reduced C9ORF72, which can lead to autophagy deficits, synergizing with repeat-dependent gain of toxicity.

Published
2020

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