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Your search keyword '"Tax, W.J.M."' showing total 402 results
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402 results on '"Tax, W.J.M."'

15. Increasing cytotoxic activity and production of reactive oxygen and nitrogen intermediates by peritoneal macrophages during the development of MODS in mice

Author

Jansen, M.J.J.M., Hendriks, T., Huyben, C.M.L.C., Tax, W.J.M., Goris, R.J.A., and Meer, J.W.M. van der

Subjects
Lupus Erythematosus, Glomerulonephritis, Membranoproliferative, Systemic, Pathofysiologie, immunologie en behandeling van nieraandoeningen, Modulation of macrophage sensitivity to inflammatory stimuli like endotoxin and zymosan, Pathophysiology, immunology and treatment of renal disease, Urinalysis, Kidney, Kidney Function Tests, Basement Membrane, Chromatin, Autoimmune Diseases, Extracellular Matrix, Glomerulonephritis, Immune System, The effect of interleukin-1 on resistance to infection, Hypertension, Versterking van de weerstand tegen infecties door interleukine-1, Lupus Erythematosus, Systemic, Modulatie van de sensitiviteit van macrofagen voor inflammatoire stimuli als endotoxine en zymosan, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries), Diabetic Angiopathies, Membranoproliferative
Abstract

Contains fulltext : 24105___.PDF (Publisher’s version ) (Open Access)

Published
1996

16. lz8 afungungal protein with immunomodulatory effects

Author

Hem, L.G. van der, Vliet, J.A. van der, Kino, K., Hoitsma, A.J., and Tax, W.J.M.

Subjects
Inflammation, Free Radicals, Anastomosis, Animal, Multiple Trauma, Multiple Organ Failure, Anastomosis, Surgical, Hand Injuries, Rejection prevention in pancreatic islet transplantation, mogelijke oorzaken en gevolgen (sepsis en ontsteking) [Sepsis en niet-bacteriële gegeneraliseerde ontsteking], causes and effects (sepsis and inflammation) [Sepsis and non-bacterial generalized inflammation], Autonomic Nervous System, Afstotingspreventie bij transplantatie van eilandjes van Langerhans (EvL), Extracellular Matrix, Foot Diseases, Disease Models, Animal, Surgical, Sepsis, Disease Models, Wounds and Injuries, Inflammation Mediators
Abstract

Item does not contain fulltext

Published
1996

17. Ling Zhi-8: A fungal protein with immunomodulatory effects

Author

Hem, L.G. van der, Vliet, J.A. van der, Kino, K., Hoitsma, A.J., and Tax, W.J.M.

Subjects
fundamentele en klinische aspecten. [Immunosuppressie met monoclonale antistoffen], fundamental and clinical aspects. [Immunosuppression with monoclonal antibodies], GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries)
Abstract

Contains fulltext : 24249___.PDF (Publisher’s version ) (Open Access)

Published
1996

18. Decreased phagocytosis of apoptotic cells in diseased SLE mice.

Author

Licht, R., Dieker, J.W.C., Jacobs, C.W.M., Tax, W.J.M., Berden, J.H.M., Licht, R., Dieker, J.W.C., Jacobs, C.W.M., Tax, W.J.M., and Berden, J.H.M.

Abstract

Contains fulltext : 57700.pdf (publisher's version ) (Closed access), Antibodies against nucleosomes are a serological hallmark of systemic lupus erythematosus (SLE). Apoptotic cells are the unique source of nucleosomes, which are formed through cleavage of chromatin by nucleases. These nucleosomes and other autoantigens targeted in SLE are expressed in apoptotic blebs or at the surface of apoptotic cells. Therefore, it is conceivable that circulating antibodies can influence apoptotic cell clearance. Using an in vitro phagocytosis assay, we analysed the phagocytic efficacy for apoptotic cells of resident peritoneal macrophages from pre-morbid and diseased lupus mice. The assay was carried out in the presence of autologous serum, using autologous apoptotic thymocytes as targets. Under these conditions macrophages from diseased MRL/lpr and NZBxNZW(F1) lupus mice, and from age-matched NZB mice showed a decreased phagocytic efficacy (decrease 47%, 48% and 37%, respectively compared to measurements in pre-morbid mice). The cause of this decrease resides in the serum, and is not due to an acquired defect of macrophages. In conclusion, during disease progression in murine SLE, apoptotic cell clearance becomes impaired, which might amplify further disease progression.

Published
2004

19. Polymorphism of Fc receptor (Fcgamma-RII) is reflected in cytokine release and adverse effects of mIgG1 anti-CD3/TCR antibody during rejection treatment after renal transplantation

Author

Tax, W.J.M., Frenken, L.A.M., Glaudemans, C.A., Tamboer, W.P.M., and Koene, R.A.P.

Subjects
Effecten van corticosteroïden en anti-glucosteroïden op renale hemodynamiek en glomerulaire permeabiliteit bij proteïnurie, Effects of cortisteroids and anti-glucocortisteroids on renal hemodynamics and glomerular permeability in proteinuria
Abstract

Item does not contain fulltext

Published
1995

26. No constitutive defect in phagocytosis of apoptotic cells by resident peritoneal macrophages from pre-morbid lupus mice.

Author

Licht, R., Jacobs, C.W.M., Tax, W.J.M., Berden, J.H.M., Licht, R., Jacobs, C.W.M., Tax, W.J.M., and Berden, J.H.M.

Abstract

Item does not contain fulltext, Antibodies against nucleosomes are a hallmark of systemic lupus erythematosus (SLE). Nucleosomes are uniquely formed during apoptosis, through cleavage of chromatin by nucleases. Increased exposure of nucleosomes to the immune system could play a role in the induction of the autoimmune repertoire in SLE. To determine whether there exists a constitutive defect in the clearance of apoptotic cells, resident peritoneal macrophages from pre-morbid SLE-prone MRL and New Zealand (NZ) mice were analysed for their efficacy to phagocytose apoptotic cells in vitro. Although differences in phagocytic efficacy of up to 50% between different strains of mice were found, these were not related to SLE development. To evaluate whether macrophages from SLE-prone mice are more susceptible to phagocytic 'exhaustion', resident peritoneal macrophages were challenged by 20 h of additional culture in the presence of apoptotic cells. In both lupus and control strains this led to an increased capacity to phagocytose fresh apoptotic cells (increase between 15 and 92%). As a control, macrophages from all strains were also exposed to 20 h of additional culture without apoptotic cells. Under this condition resident peritoneal macrophages from all SLE-prone strains, and of the SLE-parental strain NZB, displayed a significant decrease in their efficacy to phagocytose apoptotic cells (decrease between 16 and 55%). Together, these findings do not support the hypothesis that a constitutive defect in the clearance of apoptotic cells, as evaluated by testing resident peritoneal macrophages, plays an important role in the induction of SLE.

Published
2001

29. A combination of anti-CD3 and anti-CD7 ricin A-immunotoxins for the in vivo treatment of acute graft versus host disease

Author

Oosterhout, Y.V.J.M. van, Emst, J.E. van, Schattenberg, A.V.M.B., Tax, W.J.M., Ruiter, D.J., Spits, H., Nagengast, F.M., Masereeuw, R., Evers, S.M.M.A., Witte, T.J.M. de, Preijers, F.W.M.B., Oosterhout, Y.V.J.M. van, Emst, J.E. van, Schattenberg, A.V.M.B., Tax, W.J.M., Ruiter, D.J., Spits, H., Nagengast, F.M., Masereeuw, R., Evers, S.M.M.A., Witte, T.J.M. de, and Preijers, F.W.M.B.

Abstract

Item does not contain fulltext

Published
2000

38. In vivo ANA is a fixation artifact : nucleosome-complexed antinucleosome autoantibodies bind to the cell surface and are internalized

Author

Kramers, K., Bruggen, M.C.J. van, Rijke-Schilder, G.P.M., Dijkman, H.B.P.M., Hylkema, M.N., Croes, H.J.E., Fransen, J.A.M., Assmann, K.J.M., Tax, W.J.M., Smeenk, R.J.T., Berden, J.H.M., Kramers, K., Bruggen, M.C.J. van, Rijke-Schilder, G.P.M., Dijkman, H.B.P.M., Hylkema, M.N., Croes, H.J.E., Fransen, J.A.M., Assmann, K.J.M., Tax, W.J.M., Smeenk, R.J.T., and Berden, J.H.M.

Abstract

Contains fulltext : 24092___.PDF (publisher's version ) (Open Access)

Published
1996

41. Ling Zhi-8 - Studies of a New Immunomodulating Agent

Author

Hem, L.G. van der, Vliet, J.A. van der, Bocken, C.F.M., Kino, K., Hoitsma, A.J., Tax, W.J.M., Hem, L.G. van der, Vliet, J.A. van der, Bocken, C.F.M., Kino, K., Hoitsma, A.J., and Tax, W.J.M.

Abstract

Item does not contain fulltext

Published
1995

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