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4 results on '"Tawhid, Muhammad"'

2. BIOCHEMICAL ASSAY FOR DETECTION OF PATHOGENIC AND PROBIOTIC BACTERIA AT SHRIMP AND PRAWN FROM WILD AND DIFFERENT CULTURE CONDITIONS IN BANGLADESH.

Author

Tawhid, Muhammad, Islam, Mohammed Mafizul, Amanat, Muhammed, and Tandon, Sapna

Subjects
*PATHOGENIC bacteria, *ENTEROBACTER aerogenes, *SHRIMPS, *SHIGELLA flexneri, *KLEBSIELLA pneumoniae, *STAPHYLOCOCCUS aureus, *VIBRIO cholerae
Abstract

We conducted biochemical assays on shrimp and prawn samples in Bangladesh, revealing the presence of both harmful and beneficial bacteria. Pathogens such as Escherichia coli, Klebsiella pneumonia, Vibrio cholera, Pseudomonas aeruginosa, Clostridium perfringens, Salmonella typhimurium, Shigella flexneri, Listeria monocytogenes, and Staphylococcus aureus were detected in these samples, with Escherichia coli being the most prevalent. Additionally, we identified three potential probiotic bacteria - Bacillus subtilis, Lactobacillus spp., and Enterobacter aerogenes. These probiotics can enhance immunity, support survival, and have minimal environmental impact. Shrimp and prawn farms in Bangladesh may be susceptible to harmful microorganisms due to contaminated water sources and subpar sanitation during post-harvest handling and processing. Our use of biochemical characterization proves a dependable method for distinguishing pathogenic and probiotic bacteria in shrimp and prawns, offering valuable insights for future disease research. [ABSTRACT FROM AUTHOR]

Published
2024
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3. Molecular Docking, ADMET, QSAR, Biological Activity and Toxicity Prediction of Selected Natural Products and Act as the Stimulators of Antioxidant Superoxide Dismutase Enzyme

Author

Tawhid, Muhammad, Amanat, Muhammed, Islam, Mohammed Mafizul, and Md. Murad Hossain

Subjects
Natural products, antioxidants, superoxide dismutase, molecular docking, biological activity, ADMET study, QSAR, Toxicity
Abstract

Objective: Antioxidants are substances that can prevent or delay cell damage caused by free radicals, which are unstable molecules produced by the body, in response to the environment and other pressures. Molecular docking is used to predict and analyze the interactions between protein receptors and ligands. In this study, efforts have been made to identify natural products with antioxidant activity using Autodock PyRx 0.8.. Methods: Autodock PyRx 0.8 was used to prepare for docking and was also used to calculate the binding energy. Virtual analysis of the docking site was analyzed by PyRx, PyMol & Discovery studio 2020 clients. The structure of the superoxide dismutase (1CB4) was obtained from the protein data bank and the structure of the ligand was collected from the PubChem database. Results: All selected ligands (ligands 1, 3, 4, 5, 6) compared to the standard drug ascorbic acid satisfied Lipinski's rule of five and exhibited the highest binding affinity except ligand 2. The higher binding affinity and drug conductivity of all compounds suggest that it could be further explored as SOD promoters. Conclusion: We found that selected natural products could be potential antioxidants.

Published
2022
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