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139 results on '"Tavmergen, E"'

2. Endocrinology and reproductive medicine

Author

Mardi A., Rahimi G., Amani M., Mashoufi M., Kheirkhah M., Ghaffari Novin M., Pierovi T., Soleimani Rad J., Vanlioglu F., Karaman Y., Bingol B., Tavmergen E., Akdogan A., Akman A., Levi R., Tavmergen Goker EN., Ates U., Seyhan A., Atmaca U., Ortakuz S., Ata B., Akar S., Usta T., Özdemir B., Sidal B., Yoldemir T., Gee A., Sutherland P., Bowman M., Fraser I. S., Haydardedeoglu B., Bagis T., Kilicdag E. B., Simsek E., Aslan E., Zeyneloglu H. B., Kahyaoglu S., Turgay I., Ertas E., Yilmaz B., Var T., Batioglu S., Muftuoglu K., Tekcan C., Naki M. M., Uysal A., Güzin K., Yücel N., Kanadikirik F., Kelekci S., Savan K., Kalyoncu S., Gokturk U., Oral H., Mollamahmutoglu L., Ertas I. E., Mollamahmutoglu L., Kahveci S., Dogan M., Mollamahmutoglu L., Isik A., Saygili U., Gol M., Koyuncuoglu M., Uslu T., Erten O., Ciftci B., Biri A., Bozkurt N., Karabacak O., Himmetoglu O., Amir Jannati N., Nouri M., Hascalik S., Celik O., Parlakpinar H., Mizrak B., Ozsahin M., Önder C., Gezginc K., Colakoglu M., Demir S. C., Cetin M. T., Kadayifci O., Güzel A. B., Polat I., Yildirim G., Özdemir A., Tekirdag Ali I., Kizkin S., Engin-Ustun Y., Ustun Y., Ozcan C., Serbest S., Ozisik H. I., Ergenoglu M., Goker E. N. T., Uckuyu A., Ozcimen E. E., Nisanoglu O., Onal C., Akgun S., Koc S., Cebi Z., Sönmez S., Yasar L., Küpelioglu L., Bilecan S., Aygün M., Zebitay A. G., Dursun P., Ötegen Ü., Bozdag G., Yarali H., Demirci F., Mun S., Eraydin E., Sadik S., Sipahi C., Bayol Ü., Sarikaya S., Garipoglu Dalgin E., Delilbasi L., Gursoy R., Engin-Ustun Y., Meydanli M. M., Atmaca R., Kafkasli A., Canda M. T., Kucuk M., Bagriyanik H. A., Ozyurt D., Canda T., Güven M. A., Tamsoy S., Kaymak O., Ozkale D., Okyay R. E., Neslihanoglu R., Mollamahmutoglu L., Basaran A., Gultekin M., Saygili Yilmaz E., Esinler I., Bayer U., Gunalp S., Aksu T., Gultekin M., Leventerler H., Taga S., Cetin T., Solmaz S., Dikmen N., Karalök H., Ilter E., Tufekci C., Yilmaz S., Karalök A. E., Batur O., Kilicdag E., Haydardedeoglu B., Tarim E., Api M., Gültekin E., Görgen H., Cetin A., Yayla M., Özkilic T., Arikan I., Abali R., Arikan D., Bozkurt S., Demir B., Gunalp S., Erden A. C., Özcan J., Yazicioglu F., and Demirbas R.

Published
2005
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9. İnfertil Türk erkeklerinde MTHFR genindeki C677T ve A1298C polimorfizmlerinin azosperm ve oligosperm gelişim riski üzerindeki etkisinin araştırılması

Author

Vardarlı A T, Bozok Cetintas, Tavmergen E, Zuhal Eroglu, Ulukus M, and Semerci B

Subjects
Gynecology, Azoospermia, medicine.medical_specialty, biology, business.industry, urologic and male genital diseases, medicine.disease, Male infertility, Oligospermia, Methylenetetrahydrofolate reductase, Genotype, medicine, biology.protein, Allele, Genetic risk factor, business, Genotyping
Abstract

Aim: We aimed to investigate the relationship between unexplained male infertility, and the -677C/T (rs1801133) and -1298A/C (rs1801131) polymorphisms of the MTHFR gene in a group of Turkish infertile men with non-obstructive azoospermia and severe oligozoospermia in this study. Materials and Methods: Study group includes 50 non-obstructive azoospermic patients, 50 severe oligospermic patients and 50 healthy controls with normal sperm parameters who had had more than one child. Genotyping was performed by generated amplicons from melting curve analysis after real time PCR. Results: The distribution of the 677CC genotype was significantly higher in the control group than the infertile group (p= 0.046). There was a significant frequency of the polymorphic T allele in infertile patients higher than the control group (p=0.015). Neither the frequency, nor the allelic distribution of A1298C genotype was different between infertile groups compared with the control. Conclusions: The MTHFR 677TT genotype is a genetic risk factor for unexplained male infertility, especially in the group with oligospermia and non-obstructive azoospermia.

Published
2014

10. EVALUATION OF PREIMPLANTATION GENETIC ANEUPLOIDY SCREENING CASES AT A REFERENCE GENETICS CENTER: 10 YEARS' EXPERIENCE

Author

Durmaz, B., Karaca, E., Goker, E. N. Tavmergen, Tavmergen, E., Sahin, G., Akdogan, A., Yasar, B. P., Gunduz, C., Özkınay, Ferda, and Ege Üniversitesi

Subjects
Genetic testing, Preimplantation genetic screening, Aneuploidy
Abstract

WOS: 000395220800002, PubMed ID: 30226964, Evaluation of preimplantation genetic aneuploidy screening cases at a reference genetics center: 10 years' experience: The aim of this study is to review and evaluate our preimplantation genetic screening (PGS) records in terms of their demographic data, indications, cytogenetic results, pregnancy outcomes and discuss these findings in different aspects. PGS was performed in a total of 84 couples (87 cycles) between the period 2005 to 2015. Biopsied blastomeres from embryos on day 3 were fixed and fluorescence in situ hybridization was carried out for chromosomes 13, 16, 18, 21, 22, X and Y depending on the indication. The diagnostic and clinical data were retrospectively evaluated. A total of 450 blastomeres were biopsied. Ninety-eight of them were found to be suitable for transfer. They were transferred to 72 patients in 75 cycles resulting in 23 pregnancies and 20 healthy births. The most common indication was unexplained infertility. The implantation rate was calculated as 23.4% whereas the take-home baby rate was 26.6% per transfer. The highest rate of healthy living births is achieved in patients having low grade maternal mosaic sex chromosomal aneuploidy. All living births achieved by PGS had normal chromosomal structure which we can propose it as an alternative test for couples at risk to select normal embryos to improve the outcomes of assisted reproductive procedures and to avoid the transfer of chromosomally unbalanced and multiple embryos.

Published
2016

11. Evaluation of preimplantation genetic aneuploidy screening cases at a reference i genetics center: 10 years' experience

Author

Durmaz, B., Karaca, E., Tavmergen Goker, E. N., Tavmergen, E., Sahn, G., Akdogan, A., Yasar, B. R., Cumhur Gunduz, Ozkinay, F., and Ege Üniversitesi

Subjects
ComputingMilieux_MANAGEMENTOFCOMPUTINGANDINFORMATIONSYSTEMS, ComputingMethodologies_PATTERNRECOGNITION, Genetic testing, ComputerSystemsOrganization_COMPUTER-COMMUNICATIONNETWORKS, Preimplantation genetic screening, InformationSystems_MISCELLANEOUS, Aneuploidy
Abstract

PubMed ID: 30226964, Evaluation of preimplantation genetic aneuploidy screening cases at a reference genetics center: 10years' experience: The aim of this study is to review and evaluate our preimplantation genetic screening (PGS) records in terms of their demographic data, indications, cytogenetic results, pregnancy outcomes and discuss these findings in different aspects. PGS was performed in a total of 84 couples (87 cycles) between the period 2005 to 2015. Biopsied biastomeres from embryos on day 3 were fixed and fluorescence in situ hybridization was carried out for chromosomes 13, 16, 18, 21, 22, X and Y depending on the indication. The diagnostic and clinical data were retrospectively evaluated. A total of450 biastomeres were biopsied. Ninety-eight of them were found to be suitable for transfer. They were transferred to 72 patients in 75 cycles resulting in 23 pregnancies and 20 healthy births. The most common indication wasjunexplained infertility. The implantation rate was calculated as 23.4% whereas the take-home baby rate was 26.6% per transfer. The highest rate of healthy living births is achieved in patients having low grade maternal mosaic sex chromosomal aneuploidy. All living births achieved by PGS had normal chromosomal structure which we can propose it as an alternative test for couples at risk to select normal embryos to improve the outcomes of assisted reproductive procedures and to avoid the transfer of chromosomally unbalanced and multiple embryos.

Published
2016

12. Genotyping of β-globin gene mutations in single lymphocytes: A preliminary study for preimplantation genetic diagnosis of monogenic disorders

Author

Durmaz, B. Ozkinay, F. Onay, H. Karaca, E. Aydinok, Y. Tavmergen, E. Vrettou, C. Traeger-Synodinos, J. Kanavakis, E.

Abstract

Hemoglobinopathies, especially β-thalassemia (β-thal), represent an important health burden in Mediterranean countries like Turkey. Some couples prefer the option of preimplantation genetic diagnosis (PGD). However, clinical application of PGD, especially for the monogenic disorders is technically demanding. To ensure reliable results, protocols need to be robust and well standardized. Ideally PGD-PCR (polymerase chain reaction) protocols should be based on multiplex and fluorescent PCR for analysis of the disease-causing mutation(s) along with linked markers across the disease-associated locus. In this study, we aimed to constitute a protocol in single cells involving first round multiplex PCR with primers to amplify the region of the β-globin gene containing the most common mutations. Two microsatellites linked to the β-globin gene cluster (D11S4891, D11S2362) and two unlinked (D13S314, GABRB3) microsatellite markers, were used to rule out allele dropout (ADO) and contamination; followed by nested real-time PCR for genotyping the β-globin mutations. We also investigated the allele frequencies and heterozygote rates of these microsatellites in the Turkish population that have not been reported to date. This protocol was tested in 100 single lymphocytes from heterozygotes with known β-globin mutations. Amplification failure was detected in one lymphocyte (1%) and ADO was observed in two lymphocytes (2%). No contamination was detected. All results were concordant with the genotypes of the patients. Overall, this protocol was demonstrated to be sensitive, accurate, reliable and rapid for the detection of β-globin mutations in single cells and shows potential for the clinical application of PGD for hemoglobinopathies in the Turkish population. Copyright © Informa Healthcare USA, Inc.

Published
2012

13. The effects of GnRH an alogs on serum and follicularfluid leptin levels and pregnancy outcomes in short protocols of assisted reproductive technology [Yardi{dotless}mci{dotless} üreme tekniklerinde ki{dotless}sa protokol uygulamalari{dotless}nda GnRH analoglari{dotless}ni{dotless}n serum ve foliküler leptin seviyeleri ve gebelik sonuçlari{dotless} üzerine etkileri]

Author

Ergenoglu M.A., Yeniel A.O., Akdogan A., GÖker E.N.T., Tavmergen E., and Ege Üniversitesi

Subjects
Leptin, endocrine system, GnRH antagonist, GnRH agonist, hormones, hormone substitutes, and hormone antagonists, ART, Prolactin
Abstract

Objective: To determine serum and follicular leptin levels in patients using gonadotropin releasing hormone agonist and antagonist in Assisted Reproductive Technology short protocol cycles and to evaluate pregnancy outcomes. Material and Methods: Patients randomly selected to join assisted reproductive technology cycles during February 2004-July 2004 were enrolled in this study. Group 1 consisted of 21 patients receiving r FSH+ GnRH agonists, whereas Group 2 consisted of 34 patients who received r FSH +GnRH antagonists. During the ovulation induction period 5 serum samples were collected (induction day 1, day 3 or antagonist starting day, human chorionic hormone day, oocyte pickup day, and twelfth day of embryo transfer). Follicular fluid samples were collected to be evaluated for leptin, estradiol, prolactin and luteinizing hormone. Results: There was no difference in age, basal FSH, basal LH, and basal E2 between groups. Serum leptin levels were similar in both groups. Also, when each group's serum leptin levels were evaluated according to the presence of pregnancy, there was no significant difference in both groups. When follicle leptin levels were evaluated according to the existence of pregnancy, in both groups the follicle leptin levels were lower in pregnant participants but this difference was not statistically significant. When obesity is defined as body mass index over 26.5, there is a correlation between obesity and leptin levels in Group 2. Conclusion: Our results have shown that both agonists and antagonists have similar efficacy and effect in poor responder women. Leptin levels in either groups, whether pregnant or non-pregnant were not statistically different. This result shows the need for more studies on leptin in infertility. © 2012 by the Turkish-German Gynecological Education and Research Foundation.

Published
2012

15. Screening of Y chromosome microdeletion which contains AZF regions in 71 Turkish azoospermic men

Author

Okutman-Emonts, O, Pehlivan, S, Tavmergen, E, Tavmergen-Goker, EN, Özkınay, F, and Ege Üniversitesi

Subjects
Y chromosome, azoospermic men, azoospermia factor (AZF), microdeletion
Abstract

WOS: 000222686500007, PubMed ID: 15287420, Screening of Y chromosome microdeletion which contains AZF regions in 71 turkish azoospermic men: In 71 Turkish men Y chromosome microdeletions have been studied before intracytoplasmic sperm injection (ICSI). DNA samples were amplified with 18 STS primers of the azoospermia factor (AZF) region on the Y chromosome by using multiplex polymerase chain reaction (PCR). Microdeletions were detected in 4 azoospermic men (5.6%); one with a deletion in the AZFb region, while the 3 others had a large deletion extending over multiple chromosomal regions (AZFb+c+d and AZFa+b+c+d). In the patients with microdeletion, no spermatogenetic activity could be detected in testis biopsies. This result confirms the idea that Y chromosome microdeletion analysis is important in investigating the possibility of finding sperm in testicular sperm extraction (TESE). Therefore, we point out the importance of genetic testing and counselling regarding Y chromosome microdeletion for couples requesting ICSI.

Published
2004

25. REPRODUCTIVE ENDOCRINOLOGY

Author

Karasu, Y., primary, Dilbaz, B., additional, Demir, B., additional, Dilbaz, S., additional, Secilmis Kerimoglu, O., additional, Ercan, C. M., additional, Keskin, U., additional, Korkmaz, C., additional, Duru, N. K., additional, Ergun, A., additional, de Zuniga, I., additional, Horton, M., additional, Oubina, A., additional, Scotti, L., additional, Abramovich, D., additional, Pascuali, N., additional, Tesone, M., additional, Parborell, F., additional, Bouzas, N., additional, Yang, X. H., additional, Chen, S. L., additional, Chen, X., additional, Ye, D. S., additional, Zheng, H. Y., additional, Nyboe Andersen, A., additional, Lauritsen, M. P., additional, Thuesen, L. L., additional, Khodadadi, M., additional, Shivabasavaiah, S., additional, Mozafari, R., additional, Ansari, Z., additional, Hamdine, O., additional, Broekmans, F., additional, Eijkemans, M. J. C., additional, Cohlen, B. J., additional, Verhoeff, A., additional, van Dop, P. A., additional, Bernardus, R. E., additional, Lambalk, C. B., additional, Oosterhuis, G. J. E., additional, Holleboom, C., additional, van den Dool-Maasland, G. C., additional, Verburg, H. J., additional, van der Heijden, P. F. M., additional, Blankhart, A., additional, Fauser, B. C. J. M., additional, Laven, J. S. E., additional, Macklon, N. S., additional, Agudo, D., additional, Lopez, C., additional, Alonso, M., additional, Huguet, E., additional, Bronet, F., additional, Garcia-Velasco, J. A., additional, Requena, A., additional, Gonzalez Comadran, M., additional, Checa, M. A., additional, Duran, M., additional, Fabregues, F., additional, Carreras, R., additional, Ersahin, A., additional, Kahraman, S., additional, Kavrut, M., additional, Gorgen, B., additional, Acet, M., additional, Dokuzeylul, N., additional, Aybar, F., additional, Lim, S. Y., additional, Park, J. C., additional, Bae, J. G., additional, Kim, J. I., additional, Rhee, J. H., additional, Mahran, A., additional, Abdelmeged, A., additional, El-Adawy, A., additional, Eissa, M., additional, Darne, J., additional, Shaw, R. W., additional, Amer, S. A., additional, Dai, A., additional, Yan, G., additional, He, Q., additional, Hu, Y., additional, Sun, H., additional, Ferrero, H., additional, Gomez, R., additional, Garcia-Pascual, C. M., additional, Simon, C., additional, Gaytan, F., additional, Pellicer, A., additional, Garcia Pascual, C. M., additional, Zimmermann, R. C., additional, Madani, T., additional, Mohammadi Yeganeh, L., additional, Khodabakhshi, S. H., additional, Akhoond, M. R., additional, Hasani, F., additional, Monzo, C., additional, Haouzi, D., additional, Assou, S., additional, Dechaud, H., additional, Hamamah, S., additional, Amer, S., additional, Mahran, M., additional, Shaw, R., additional, Lan, V., additional, Nhu, G., additional, Tuong, H., additional, Mahmoud Youssef, M. A., additional, Aboulfoutouh, I., additional, Al-inany, H., additional, Van Der Veen, F., additional, Van Wely, M., additional, Zhang, Q., additional, Fang, T., additional, Wu, S., additional, Zhang, L., additional, Wang, B., additional, Li, X., additional, Ding, L., additional, Day, A., additional, Fulford, B., additional, Boivin, J., additional, Alanbay, I., additional, Sakinci, M., additional, Coksuer, H., additional, Ozturk, M., additional, Tapan, S., additional, Chung, C. K., additional, Chung, Y., additional, Seo, S., additional, Aksoy, S., additional, Yakin, K., additional, Caliskan, S., additional, Salar, Z., additional, Ata, B., additional, Urman, B., additional, Devroey, P., additional, Arce, J. C., additional, Harrison, K., additional, Irving, J., additional, Osborn, J., additional, Harrison, M., additional, Fusi, F., additional, Arnoldi, M., additional, Cappato, M., additional, Galbignani, E., additional, Galimberti, A., additional, Zanga, L., additional, Frigerio, L., additional, Taghavi, S. A., additional, Ashrafi, M., additional, Karimian, L., additional, Mehdizadeh, M., additional, Joghataie, M., additional, Aflatoonian, R., additional, Xu, B., additional, Cui, Y. G., additional, Gao, L. L., additional, Diao, F. Y., additional, Li, M., additional, Liu, X. Q., additional, Liu, J. Y., additional, Jiang, F., additional, Jee, B. C., additional, Yi, G., additional, Kim, J. Y., additional, Suh, C. S., additional, Kim, S. H., additional, Liu, S., additional, Cai, L. B., additional, Liu, J. J., additional, Ma, X., additional, Geenen, E., additional, Bots, R. S. G. M., additional, Smeenk, J. M. J., additional, Chang, E., additional, Lee, W., additional, Seok, H., additional, Kim, Y., additional, Han, J., additional, Yoon, T., additional, Lazaros, L., additional, Xita, N., additional, Zikopoulos, K., additional, Makrydimas, G., additional, Kaponis, A., additional, Sofikitis, N., additional, Stefos, T., additional, Hatzi, E., additional, Georgiou, I., additional, Atilgan, R., additional, Kumbak, B., additional, Sahin, L., additional, Ozkan, Z. S., additional, Simsek, M., additional, Sapmaz, E., additional, Karacan, M., additional, Alwaeely, F. A., additional, Cebi, Z., additional, Berberoglugil, M., additional, Ulug, M., additional, Camlibel, T., additional, Yelke, H., additional, Kamalak, Z., additional, Carlioglu, A., additional, Akdeniz, D., additional, Uysal, S., additional, Inegol Gumus, I., additional, Ozturk Turhan, N., additional, Regan, S., additional, Yovich, J., additional, Stanger, J., additional, Almahbobi, G., additional, Kara, M., additional, Aydin, T., additional, Turktekin, N., additional, Youssef, M., additional, Al-Inany, H., additional, van der Veen, F., additional, van Wely, M., additional, Hart, R., additional, Doherty, D., additional, Frederiksen, H., additional, Keelan, J., additional, Pennell, C., additional, Newnham, J., additional, Skakkebaek, N., additional, Main, K., additional, Salem, H. T., additional, Ismail, A. a., additional, Viola, M., additional, Siebert, T. I., additional, Steyn, D. W., additional, Kruger, T. F., additional, Robin, G., additional, Dewailly, D., additional, Thomas, P., additional, Leroy, M., additional, Lefebvre, C., additional, soudan, B., additional, Pigny, P., additional, Decanter, C., additional, ElPrince, M., additional, Wang, F., additional, Zhu, Y., additional, Huang, H., additional, Valdez Morales, F., additional, Vital Reyes, V., additional, Mendoza Rodriguez, A., additional, Gamboa Dominguez, A., additional, Cerbon, M., additional, Aizpurua, J., additional, Ramos, B., additional, Luehr, B., additional, Moragues, I., additional, Rogel, S., additional, Cil, A. P., additional, Guler, Z. B., additional, Kisa, U., additional, Albu, A., additional, Radian, S., additional, Grigorescu, F., additional, Albu, D., additional, Fica, S., additional, Al Boghdady, L., additional, Ghanem, M. E., additional, Hassan, M., additional, Helal, A. S., additional, Ozdogan, S., additional, Ozdegirmenci, O., additional, Cinar, O., additional, Goktolga, U., additional, Seeber, B., additional, Tsybulyak, I., additional, Bottcher, B., additional, Grubinger, T., additional, Czech, T., additional, Wildt, L., additional, Wojcik, J., additional, Howles, C. M., additional, Destenaves, B., additional, Arriagada, P., additional, Tavmergen, E., additional, Sahin, G., additional, Akdogan, A., additional, Levi, R., additional, Goker, E. N. T., additional, Loft, A., additional, Smitz, J., additional, Ricciardi, L., additional, Di Florio, C., additional, Busacca, M., additional, Gagliano, D., additional, Immediata, V., additional, Selvaggi, L., additional, Romualdi, D., additional, Guido, M., additional, Bouhanna, P., additional, Salama, S., additional, Kamoud, Z., additional, Torre, A., additional, Paillusson, B., additional, Fuchs, F., additional, Bailly, M., additional, Wainer, R., additional, Tagliaferri, V., additional, Tartaglia, C., additional, Cirella, E., additional, Aflatoonian, A., additional, Eftekhar, M., additional, Mohammadian, F., additional, Yousefnejad, F., additional, De Cicco, S., additional, Campagna, G., additional, Depalo, R., additional, Lippolis, C., additional, Vacca, M., additional, Nardelli, C., additional, Cavallini, A., additional, Panic, T., additional, Mitulovic, G., additional, Franz, M., additional, Sator, K., additional, Tschugguel, W., additional, Pietrowski, D., additional, Hildebrandt, T., additional, Cupisti, S., additional, Giltay, E. J., additional, Gooren, L. J., additional, Oppelt, P. G., additional, Hackl, J., additional, Reissmann, C., additional, Schulze, C., additional, Heusinger, K., additional, Attig, M., additional, Hoffmann, I., additional, Beckmann, M. W., additional, Dittrich, R., additional, Mueller, A., additional, Sharma, S., additional, Singh, S., additional, Chakravarty, A., additional, Sarkar, A., additional, Rajani, S., additional, Chakravarty, B. N., additional, Ozturk, E., additional, Isikoglu, S., additional, Kul, S., additional, Hillensjo, T., additional, Witjes, H., additional, Elbers, J., additional, Mannaerts, B., additional, Gordon, K., additional, Krasnopolskaya, K., additional, Galaktionova, A., additional, Gorskaya, O., additional, Kabanova, D., additional, Venturella, R., additional, Morelli, M., additional, Mocciaro, R., additional, Capasso, S., additional, Cappiello, F., additional, Zullo, F., additional, Monterde, M., additional, Marzal, A., additional, Vega, O., additional, Rubio-Rubio, J. M., additional, Diaz-Garcia, C., additional, Kolibianakis, E., additional, Griesinger, G., additional, Yding Andersen, C., additional, Ocal, P., additional, Guralp, O., additional, Aydogan, B., additional, Irez, T., additional, Cetin, M., additional, Senol, H., additional, Erol, N., additional, Rombauts, L., additional, Van Kuijk, J., additional, Montagut, J., additional, Nogueira, D., additional, Porcu, G., additional, Chomier, M., additional, Giorgetti, C., additional, Nicollet, B., additional, Degoy, J., additional, Lehert, P., additional, Alviggi, C., additional, De Rosa, P., additional, Vallone, R., additional, Picarelli, S., additional, Coppola, M., additional, Conforti, A., additional, Strina, I., additional, Di Carlo, C., additional, De Placido, G., additional, Haeberle, L., additional, Demirtas, O., additional, Fatemi, H., additional, Shapiro, B. S., additional, Mannaerts, B. M., additional, Chimote, M. N., additional, Mehta, B. N., additional, Chimote, N. N., additional, Nath, N. M., additional, Chimote, N. M., additional, Karia, S., additional, Bonifacio, M., additional, Bowman, M., additional, McArthur, S., additional, Jung, J., additional, Cho, S., additional, Choi, Y., additional, Lee, B., additional, Lee, K. H., additional, Kim, C. H., additional, Kwon, S. K., additional, Kang, B. M., additional, Jung, K. S., additional, Basios, G., additional, Trakakis, E., additional, Hatziagelaki, E., additional, Vaggopoulos, V., additional, Tsiavou, A., additional, Panagopoulos, P., additional, Chrelias, C., additional, Kassanos, D., additional, Sarhan, A., additional, Elsamanoudy, A., additional, Harira, M., additional, Dogan, S., additional, Bozdag, G., additional, Esinler, I., additional, Polat, M., additional, and Yarali, H., additional

Published
2012
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26. ANDROLOGY

Author

Hu, J. C. Y., primary, Seo, B. K., additional, Neri, Q. V., additional, Rozenwaks, Z., additional, Palermo, G. D., additional, Fields, T., additional, Monahan, D., additional, Rosenwaks, Z., additional, Szkodziak, P., additional, Plewka, K., additional, Wozniak, S., additional, Czuczwar, P., additional, Mroczkowski, A., additional, Lorenzo Leon, C., additional, Hernandez, J., additional, Chinea Mendez, E., additional, Concepcion Lorenzo, C., additional, Sanabria Perez, V., additional, Puopolo, M., additional, Palumbo, A., additional, Toth, B., additional, Franz, C., additional, Montag, M., additional, Boing, A., additional, Strowitzki, T., additional, Nieuwland, R., additional, Griesinger, G., additional, Schultze-Mosgau, A., additional, Cordes, T., additional, Depenbusch, M., additional, Diedrich, K., additional, Vloeberghs, V., additional, Verheyen, G., additional, Camus, M., additional, Van de Velde, H., additional, Goossens, A., additional, Tournaye, H., additional, Coppola, G., additional, Di Caprio, G., additional, Wilding, M., additional, Ferraro, P., additional, Esposito, G., additional, Di Matteo, L., additional, Dale, R., additional, Dale, B., additional, Daoud, S., additional, Auger, J., additional, Wolf, J. P., additional, Dulioust, E., additional, Lafuente, R., additional, Lopez, G., additional, Brassesco, M., additional, Hamad, M., additional, Montenarh, M., additional, Hammadeh, M., additional, Robles, F., additional, Magli, M. C., additional, Crippa, A., additional, Pescatori, E., additional, Ferraretti, A. P., additional, Gianaroli, L., additional, Zahiri, M., additional, Movahedin, M., additional, Mowla, S. J., additional, Noruzinia, M., additional, Crivello, A. 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A., additional, Macanovic, B., additional, Otasevic, V., additional, Korac, A., additional, Vucetic, M., additional, Garalejic, E., additional, Ivanovic Burmazovic, I., additional, Filipovic, M. 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G., additional, Ocal, P., additional, Sahmay, S., additional, Karahuseyinoglu, S., additional, Usta, T., additional, Repping, S., additional, Silber, S., additional, Van Wely, M., additional, Datta, A., additional, Nayini, K., additional, Eapen, A., additional, Barlow, S., additional, Lockwood, G., additional, Tavares, R., additional, Baptista, M., additional, Publicover, S. J., additional, Ramalho-Santos, J., additional, Vaamonde, D., additional, Rodriguez, I., additional, Diaz, A., additional, Darr, C., additional, Chow, V., additional, Ma, S., additional, Smith, R., additional, Jeria, F., additional, Rivera, J., additional, Gabler, F., additional, Nicolai, H., additional, Cunha, M., additional, Viana, P., additional, Goncalves, A., additional, Silva, J., additional, Oliveira, C., additional, Teixeira da Silva, J., additional, Ferraz, L., additional, Madureira, C., additional, Doria, S., additional, Sousa, M., additional, Barros, A., additional, Herrero, M. B., additional, Delbes, G., additional, Troueng, E., additional, Chan, P. T. K., additional, Vingris, L., additional, Setti, A. S., additional, Braga, D. P. A. F., additional, Figueira, R. C. S., additional, Iaconelli, A., additional, Borges, E., additional, Sargin Oruc, A., additional, Gulerman, C., additional, Zeyrek, T., additional, Yilmaz, N., additional, Tuzcuoglu, D., additional, Cicek, N., additional, Scarselli, F., additional, Terribile, M., additional, Franco, G., additional, Zavaglia, D., additional, Dente, D., additional, Zazzaro, V., additional, Riccio, T., additional, Minasi, M. G., additional, Greco, E., additional, Cejudo-Roman, A., additional, Ravina, C. G., additional, Candenas, L., additional, Gallardo-Castro, M., additional, Martin-Lozano, D., additional, Fernandez-Sanchez, M., additional, Pinto, F. M., additional, Balasuriya, A., additional, Serhal, P., additional, Doshi, A., additional, Harper, J., additional, Romany, L., additional, Fernandez, J. 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A., additional, Sahin, O., additional, Bakircioglu, E., additional, Serdarogullari, M., additional, Bayram, A., additional, Yayla, S., additional, Ulug, U., additional, Tosun, S. B., additional, Bahceci, M., additional, Yoon, S. Y., additional, Shin, D. H., additional, Shin, T. E., additional, Park, E. A., additional, Won, H. J., additional, Kim, Y. S., additional, Lee, W. S., additional, Yoon, T. K., additional, Lee, D. R., additional, Hattori, H., additional, Nakajo, Y., additional, Kyoya, T., additional, Kuchiki, M., additional, Kanto, S., additional, Kyono, K., additional, Park, M., additional, Park, M. R., additional, Lim, E. J., additional, Choi, Y., additional, Mitra, A., additional, Bhattacharya, J., additional, Kundu, A., additional, Mukhopadhaya, D., additional, Pal, M., additional, Enciso, M., additional, Alfarawati, S., additional, Wells, D., additional, Abad, C., additional, Amengual, M. J., additional, Esmaeili, V., additional, Safiri, M., additional, Shahverdi, A. H., additional, Alizadeh, A. R., additional, Ebrahimi, B., additional, Brucculeri, A. M., additional, Ruvolo, G., additional, Giovannelli, L., additional, Schillaci, R., additional, Cittadini, E., additional, Scaravelli, G., additional, Perino, A., additional, Cortes Gallego, S., additional, Gabriel Segovia, A., additional, Nunez Calonge, R., additional, Guijarro Ponce, A., additional, Ortega Lopez, L., additional, Caballero Peregrin, P., additional, Heindryckx, B., additional, Kashir, J., additional, Jones, C., additional, Mounce, G., additional, Ramadan, W. M., additional, Lemmon, B., additional, De Sutter, P., additional, Parrington, J., additional, Turner, K., additional, Child, T., additional, McVeigh, E., additional, Coward, K., additional, Tosun, S., additional, Ciray, N., additional, Saeidi, S., additional, Shapouri, F., additional, Hoseinifar, H., additional, Sabbaghian, M., additional, Pacey, A., additional, Aflatoonian, R., additional, Bosco, L., additional, Carrillo, L., additional, Pane, A., additional, Manno, M., additional, Roccheri, M. C., additional, Selles, E., additional, Garcia-Herrero, S., additional, Martinez, J. A., additional, Munoz, M., additional, Durmaz, A., additional, Dikmen, N., additional, Gunduz, C., additional, Tavmergen Goker, E., additional, Tavmergen, E., additional, Gozuacik, D., additional, Vatansever, H. S., additional, Kara, B., additional, Calimlioglu, N., additional, Yasar, P., additional, Semerci, B., additional, Baka, M., additional, Ozbilgin, K., additional, Karabulut, A., additional, Tekin, A., additional, Sabah, B., additional, Cottin, V., additional, Kottelat, D., additional, Fellmann, M., additional, Halm, S., additional, Rosenthaler, E., additional, Kisida, T., additional, Kojima, F., additional, Sakamoto, T., additional, Makutina, V. A., additional, Balezin, S. L., additional, Rosly, O. F., additional, Slishkina, T. V., additional, Hatzi, E., additional, Lazaros, L., additional, Xita, N., additional, Makrydimas, G., additional, Sofikitis, N., additional, Kaponis, A., additional, Stefos, T., additional, Zikopoulos, K., additional, Georgiou, I., additional, Hibi, H., additional, Ohori, T., additional, Sumitomo, M., additional, Anarte, C., additional, Calvo, I., additional, Domingo, A., additional, Presilla, N., additional, Aleman, M., additional, Bou, R., additional, Guardiola, F., additional, Agirregoikoa, J. A., additional, De Pablo, J. L., additional, Barrenetxea, G., additional, Zhylkova, I., additional, Feskov, O., additional, Feskova, I., additional, Zozulina, O., additional, Somova, O., additional, Nabi, A., additional, Khalili, M. A., additional, Roudbari, F., additional, Parmegiani, L., additional, Cognigni, G. E., additional, Bernardi, S., additional, Taraborrelli, S., additional, Troilo, E., additional, Ciampaglia, W., additional, Pocognoli, P., additional, Infante, F. E., additional, Tabarelli de fatis, C., additional, Arnone, A., additional, Maccarini, A. M., additional, Filicori, M., additional, Silva, L., additional, Oliveira, J. B. A., additional, Petersen, C. G., additional, Mauri, A. L., additional, Massaro, F. C., additional, Cavagna, M., additional, Baruffi, R. L. R., additional, Franco, J. G., additional, Fujii, Y., additional, Endou, Y., additional, Mtoyama, H., additional, Shokri, S., additional, and Aitken, R. J., additional

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2012
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27. EMBRYOLOGY

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Furia, G. U., primary, Kostelijk, E. H., additional, Vergouw, C. G., additional, Lee, H., additional, Lee, S., additional, Park, D., additional, Kang, H., additional, Lim, C., additional, Yang, K., additional, Park, Y., additional, Shin, M., additional, Beyhan, Z., additional, Fisch, J. D., additional, Sher, G., additional, Keskintepe, L., additional, VerMilyea, M. D., additional, Anthony, J. T., additional, Graham, J. R., additional, Tucker, M. J., additional, Freour, T., additional, Lattes, S., additional, Lammers, J., additional, Mansour, W., additional, Jean, M., additional, Barriere, P., additional, El Danasouri, I., additional, Gagsteiger, F., additional, Rinaldi, L., additional, Selman, H., additional, Antonova, I., additional, Milachich, T., additional, Valkova, L., additional, Shterev, A., additional, Barcroft, J., additional, Dayoub, N., additional, Thong, J., additional, Abdel Reda, H., additional, Khalaf, Y., additional, El Touky, T., additional, Cabry, R., additional, Brzakowski, R., additional, Lourdel, E., additional, Brasseur, F., additional, Copin, H., additional, Merviel, P., additional, Yamada, M., additional, Takanashi, K., additional, Hamatani, T., additional, Akutsu, H., additional, Fukunaga, T., additional, Inoue, O., additional, Ogawa, S., additional, Sugawara, K., additional, Okumura, N., additional, Chikazawa, N., additional, Kuji, N., additional, Umezawa, A., additional, Tomita, M., additional, Yoshimura, Y., additional, Van der Jeught, M., additional, Ghimire, S., additional, O'Leary, T., additional, Lierman, S., additional, Deforce, D., additional, Chuva de Sousa Lopes, S., additional, Heindryckx, B., additional, De Sutter, P., additional, Herrero, J., additional, Tejera, A., additional, De los Santos, M. J., additional, Castello, D., additional, Romero, J. L., additional, Meseguer, M., additional, Leperlier, F., additional, Mirallie, S., additional, Schats, R., additional, Al-Nofal, M., additional, Lens, J. W., additional, Rooth, H., additional, Hompes, P. G., additional, Lambalk, C. B., additional, Hreinsson, J., additional, Karlstrom, P. O., additional, Wanggren, K., additional, Lundqvist, M., additional, Vahabi, Z., additional, Eftekhari-Yazdi, P., additional, Dalman, A., additional, Ebrahimi, B., additional, Daneshzadeh, M. T., additional, Rajabpour Niknam, M., additional, Choi, E. G., additional, Rho, Y. H., additional, Oh, D. S., additional, Park, L. S., additional, Cheon, H. S., additional, Lee, C. S., additional, Kong, I. K., additional, Lee, S. C., additional, Liebenthron, J., additional, Montag, M., additional, Koster, M., additional, Toth, B., additional, Reinsberg, J., additional, van der Ven, H., additional, Strowitzki, T., additional, Morita, H., additional, Hirosawa, T., additional, Watanabe, S., additional, Wada, T., additional, Kamihata, M., additional, Kuwahata, A., additional, Ochi, M., additional, Horiuchi, T., additional, Fatemeh, H., additional, Karimian, L., additional, Fazel, M., additional, Fouladi, H., additional, Johansson, L., additional, Ruttanajit, T., additional, Chanchamroen, S., additional, Sopaboon, P., additional, Seweewanlop, S., additional, Sawakwongpra, K., additional, Jindasri, P., additional, Jantanalapruek, T., additional, Charoonchip, K., additional, Vajta, G., additional, Quangkananurug, W., additional, Yi, G., additional, Jo, J. W., additional, Jee, B. C., additional, Suh, C. S., additional, Kim, S. H., additional, Zhang, Y., additional, Zhao, H. J., additional, Cui, Y. G., additional, Gao, C., additional, Gao, L. L., additional, Liu, J. Y., additional, Sozen, E., additional, Buluc, B., additional, Vicdan, K., additional, Akarsu, C., additional, Tuncay, G., additional, Hambiliki, F., additional, Bungum, M., additional, Agapitou, K., additional, Makrakis, E., additional, Liarmakopoulou, S., additional, Anagnostopoulou, C., additional, Moustakarias, T., additional, Giannaris, D., additional, Wang, J., additional, Andonov, M., additional, Linara, E., additional, Charleson, C., additional, Ahuja, K. K., additional, Ozsoy, S., additional, Morris, M. B., additional, Day, M. L., additional, Cobo, A., additional, Viloria, T., additional, Campos, P., additional, Vallejo, B., additional, Remohi, J., additional, Roldan, M., additional, Perez-Cano, I., additional, Cruz, M., additional, Martinez, M., additional, Gadea, B., additional, Munoz, M., additional, Garrido, N., additional, Mesut, N., additional, Ciray, H. 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J., additional, Carvalho, M., additional, Cordeiro, I., additional, Leal, F., additional, Aguiar, A., additional, Nunes, J., additional, Rodrigues, C., additional, Soares, A. P., additional, Sousa, S., additional, Calhaz-Jorge, C., additional, Braga, D. P. A. F., additional, Setti, A. S., additional, Figueira, R. C. S., additional, Aoki, T., additional, Iaconelli, A., additional, Borges, E., additional, Ozkavukcu, S., additional, Sonmezer, M., additional, Atabekoglu, C., additional, Berker, B., additional, Ozmen, B., additional, Isbacar, S., additional, Ibis, E., additional, Menezes, J., additional, Lalitkumar, P. G. L., additional, Borg, P., additional, Ekwurtzel, E., additional, Nordqvist, S., additional, Vaegter, K., additional, Tristen, C., additional, Sjoblom, P., additional, Azevedo, M. C., additional, Remohi Gimenez, J., additional, Gamiz, P., additional, Albert, C., additional, Ferreira, R. C., additional, Resende, S., additional, Colturato, S. S., additional, Ferrer Buitrago, M., additional, Ferrer Robles, E., additional, Munoz Soriano, P., additional, Ruiz-Jorro, M., additional, Calatayud Lliso, C., additional, Rawe, V. Y., additional, Hanrieder, J., additional, Gulen-Yaldir, F., additional, Bergquist, J., additional, Stavreus-Evers, A., additional, Grunskis, A., additional, Bazarova, A., additional, Dundure, I., additional, Fodina, V., additional, Brikune, J., additional, Lakutins, J., additional, Pribenszky, C., additional, Cornea, M., additional, Reichart, A., additional, Uhereczky, G., additional, Losonczy, E., additional, Ficsor, L., additional, Lang, Z., additional, Ohgi, S., additional, Nakamura, C., additional, Hagiwara, C., additional, Kawashima, M., additional, Yanaihara, A., additional, Jones, G. M., additional, Biba, M., additional, Kokkali, G., additional, Vaxevanoglou, T., additional, Chronopoulou, M., additional, Petroutsou, K., additional, Sfakianoudis, K., additional, Pantos, K., additional, Romano, S., additional, Albricci, L., additional, Stoppa, M., additional, Cerza, C., additional, Sanges, F., additional, Fusco, S., additional, Capalbo, A., additional, Maggiulli, R., additional, Ubaldi, F., additional, Rienzi, L., additional, Ulrick, J., additional, Kilani, S., additional, Chapman, M., additional, Losada, C., additional, Ortega, I., additional, Pacheco, A., additional, Bronet, F., additional, Aguilar, J., additional, Ojeda, M., additional, Taboas, E., additional, Perez, M., additional, Munoz, E., additional, Pellicer, A., additional, Boumela, I., additional, Assou, S., additional, Haouzi, D., additional, Monzo, C., additional, Dechaud, H., additional, Hamamah, S., additional, Nakaoka, Y., additional, Hashimoto, S., additional, Amo, A., additional, Yamagata, K., additional, Nakano, T., additional, Akamatsu, Y., additional, Mezawa, T., additional, Ohnishi, Y., additional, Himeno, T., additional, Inoue, T., additional, Ito, K., additional, and Morimoto, Y., additional

Published
2012
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35. P-433

Author

Akdogan, A., primary, Tavmergen, E.G., additional, Ulukus, M., additional, Barut, C., additional, Levi, R., additional, and Tavmergen, E., additional

Published
2006
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38. Do analogues of gonadotrophin releasing hormone influence follicular fluid steroid levels, oocyte maturity and fertilization rates?

Author

Tavmergen, Erol, Tavmergen, Ege Nazan, Çapanoglu, Refik, Tavmergen, E, Tavmergen, E N, and Capanoğlu, R

Abstract

One-hundred-and-twelve samples of follicular fluid from 32 patients undergoing in-vitro fertilization and embryo transfer were analysed in this study. The follicular fluids were analysed for any relationships between oestradiol, progesterone and 17 alpha-hydroxyprogesterone levels, the progesterone/oestradiol and 17 alpha-hydroxyprogesterone/oestradiol ratios and oocyte maturity and fertilization rates. In Group A, consisting of women who used analogues of gonadotrophin-releasing hormone during ovarian stimulation with human menopausal gonadotrophin, the progesterone/oestradiol ratio rose in parallel with the fertilization rate (P less than 0.05). Group B comprised patients treated with human menopausal gonadotrophin alone. No significant relationship was found between the other parameters, oocyte maturation and fertilization rates in either group. [ABSTRACT FROM AUTHOR]

Published
1992

41. Controlled ovarian hyperstimulation and intrauterine insemination for infertility associated with endometriosis: a retrospective analysis.

Author

Göker, E N Tavmergen, Ozçakir, H T, Terek, M C, Levi, R, Adakan, S, and Tavmergen, E

Subjects
INFERTILITY treatment, HUMAN artificial insemination, CHORIONIC gonadotropins, COMPARATIVE studies, ENDOMETRIOSIS, ENDOMETRIUM, FALLOPIAN tube diseases, INFERTILITY, RESEARCH methodology, MEDICAL cooperation, INDUCED ovulation, RESEARCH, EVALUATION research, RETROSPECTIVE studies, DISEASE complications
Abstract

Objective: To evaluate the efficacy of controlled ovarian hyperstimulation and intrauterine insemination for infertility associated with endometriosis.Material and Methods: A retrospective analysis of 260 patients with the only diagnosis of endometriosis, or male factor, or tubal factor, or unexplained infertility were performed: a total of 56 patients with different stages of endometriosis, a control group consisting of 38 patients with male factor infertility, a group of 26 patients with tubal factor infertility and a group of 140 patients with others (unexplained infertility, ovulation disorders, cervical factor). Pregnancy rate, hormone levels, endometrial thickness and number of follicles were analyzed.Results: Clinical pregnancy rates per patient were similar between endometriosis, male factor, tubal factor, and others including unexplained infertility, ovulation disorders and cervical factor groups (10.7%, 5.4%, 11.5%, 17.9%, respectively; p>0.05). Clinical pregnancy rates per patient were not effected between the 2 subgroups of endometriosis as minimal to mild and moderate to severe [5.1% (2/39) versus 23.5% (4/17), p=0.19].Conclusion: Endometriosis did not affect the clinical pregnancy rate per patient compared to the other infertility factors. Endometriosis of various stages have no effect on the success of controlled ovarian hyperstimulation combined with intrauterine insemination. [ABSTRACT FROM AUTHOR]

Published
2002
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42. Significance of oestradiol values in IVF-ET under a combined GnRH analogue--desensitization and simultaneous gonadotrophin stimulation for the outcome of pregnancies.

Author

Mettler, L and Tavmergen, E N

Abstract

The present study was undertaken to determine the relationship between the actual value of oestradiol (E2) levels at the time of human chorionic gonadotrophin (HCG) administration and 36 h later at follicular puncture in in-vitro fertilization and embryo replacement (IVF-ET) patients and the resulting pregnancy rates. Between January and May 1988, 94 patients underwent follicular recruitment with various types of human menopausal gonadotrophin (HMG), follicle stimulating hormone (FSH) and HCG stimulation protocols. E2 and luteinizing hormone (LH) measurements were taken daily beginning on day 2 of the cycle. After an initial sonographic scan at the beginning of the treatment, vaginal sonographic follicular studies were performed based on the associated oestradiol levels from approximately day 8 of the cycle on. Four findings resulted: (i) When follicles reached a diameter of greater than 1.5 cm, the aspirated oocytes were at all stages of maturity. One can rely on follicular diameters alone if the patients' previous cycles and their E2 responses are known. (ii) A minimum plasma level of greater than 800 pg of E2 on the day of administration of HCG is predictive of a favourable pregnancy success rate per embryo transfer. Oestradiol levels do not, however, directly correlate with oocyte maturity and embryonic growth. (iii) The pregnancy rates in the low responding group when compared to the medium and high responding groups were statistically significantly lower despite replacement of an equivalent number of oocytes and cleaving embryos. (iv) We hypothesize that the responsiveness of the endometrium depends on adequate stimulation with oestradiol which it does not receive in the low responders.

Published
1989
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44. GLUCOSE TOLERANCE TESTS IN THE SINGLETON AND TWIN PREGNANCY.

Author

Saraç, F., Tutuncuoglu, P., Tavmergen, E., Saygili, F., Ozgen, A. Gökhan, and Tuzun, M.

Subjects
*DIABETES, *GLUCOSE tolerance tests, *PREGNANCY, *INSULIN resistance, *PLACENTAL hormones, *MEDICAL screening
Abstract

Objective. Gestational diabetes mellitus (GDM) is defined as glucose intolerance that is detected for the first time during pregnancy. Normal pregnancy induces insulin resistance through the diabetogenic effects of placental hormones. Glucose tolerance test results in twin and singleton pregnancies were compared in this study. Subjects and Methods. A total of 360 pregnant women were studied. 200 women (mean age 31.60±2.10 yr) had singleton pregnancies (Group I) and 160 women (mean age 28.20±2.70 yr) had twin pregnancies (Group II). 50- g, 1- hour glucose tolerance test was conducted on the first prenatal visit. An abnormal glucose screen defined as glucose ≥ 140 mg/dL was followed by a 100g, 3-hour glucose tolerance test. Gestational diabetes was defined as the presence of two or more abnormal values during the 3-hour test. Results. Gestational diabetes was found in 4 of the 200 (2%) singleton pregnant women and 8 of the 160 (5%) twin pregnant women. Group I (Singleton) was further divided into two subgroups according to whether the 1-hr plasma glucose level was < 140 mg/dl (Group Ia) or >140 mg/dL (Group Ib). Likewise, Group II pregnancies was also divided into two subgoups on the same basis. Mean screening test glucose levels were found to be 127.8±14.94 mg/dL in Group Ia and 150.8 ± 18.1 mg/dL in Group Ib women. Mean screening test glucose levels of Group IIa subjects was 92.80 ± 18.30 mg/dL while that of Group IIb subjects was 154.8 ± 27.0 mg/dL. Mean 1st h glucose levels of 100-g glucose tolerance test was found to be 131.4 ± 32.58 mg/dL in Group I, and 112.5 ± 39.6 mg/dL in Group II. Mean 2nd h glucose tolerance test values were 133.2 ± 28.8 mg/dL in Group I and 100.6±28.8 mg/dL in Group II. Mean 3rd h glucose tolerance test values were 107.6 ± 23.58 mg/dl in Group I and 72±16.9 mg/dL in Group II. Conclusion: Glucose screening results and 100-g, 3- hour glucose tolerance test values have been found to be lower in twin pregnancies than in singleton pregnancies. Therefore, we suggest that these findings be taken into account in developing diagnostic criteria for gestational diabetes in twin or more pregnancies. [ABSTRACT FROM AUTHOR]

Published
2009
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46. Reproductive and ICSI outcomes after hysteroscopic metroplasty for T-shaped uterus, a prospective follow up study.

Author

Acet F, Sahin G, Goker ENT, and Tavmergen E

Subjects
Female, Follow-Up Studies, Humans, Hysteroscopy adverse effects, Pregnancy, Prospective Studies, Sperm Injections, Intracytoplasmic, Urogenital Abnormalities, Uterus abnormalities, Uterus surgery, Abortion, Habitual epidemiology, Infertility, Female epidemiology, Infertility, Female etiology, Infertility, Female surgery
Abstract

Background: The incidence of uterine anomalies is approximately 0.5-4.7%. In infertile women, this rises to 6.3%. T-shaped uterine anomalies have been associated with infertility, recurrent implantation failure (RIF), and recurrent miscarriage (RM). Hysteroscopic metroplasty (HM) may improve the reproductive outcomes of such cases., Study Objective: We assessed the effects of hysteroscopic metroplasty on the reproductive and in vitro fertilization (IVF) outcomes in women with T-shaped uteri., Design: A prospective controlled study., Setting: A teaching hospital., Patients: The reproductive outcomes of 182 patients with primary infertility (PI), RIF, or RM who underwent hysteroscopic metroplasty to treat T-shaped uteri were prospectively analyzed., Interventions: Between January 2017 and April 2021, hysteroscopic metroplasty was performed by a single experienced surgeon. The primary outcome was the live birth rate (either spontaneous or assisted)., Measurements and Principal Results: In all, 182 patients who underwent bilateral, longitudinal, uterine-lateral wall incisions without complications were included. The clinical pregnancy rates after metroplasty were 50.9% (primary infertility group), 71.4% (RM group), and 39.5% (RIF group). During the 1-year follow-up, 25.5% of patients conceived spontaneously (all groups)., Conclusion: Hysteroscopic metroplasty should be considered for women with primary infertility, RIF, and RM with T-shaped uteri., Competing Interests: Declaration of Competing Interest The authors do not have any potential conflicts of interest to report., (Copyright © 2022 Elsevier Masson SAS. All rights reserved.)

Published
2022
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47. In vitro fertilization and preimplantation genetic diagnosis outcomes in mosaic Turner's syndrome: A retrospective cohort study from a single referral center experience.

Author

Acet F, Sahin G, Ucar AAO, Emirdar V, Karaca E, Durmaz B, Goker ENT, and Tavmergen E

Subjects
Female, Fertilization in Vitro, Humans, Live Birth, Monosomy, Pregnancy, Referral and Consultation, Retrospective Studies, Preimplantation Diagnosis, Turner Syndrome
Abstract

Background: Patients with mosaic Turner syndrome who have normal phenotype and pubertal development may be diagnosed based on karyotype examination which is performed due to recurrent abortion or recurrent implantation failure; but according to the literature review, reproductive and obstetric consequences of these cases are based on case reports. There are contradictory publications on this subject recommending pre-implantation genetic testing (PGT) may be a solution to reduce the high risk for the fetus and perform normal embryo transfer., Aim: In this study, our aim was to evaluate the results of in vitro fertilization and preimplantation genetic diagnosis in patients with low-grade and high-grade mosaic Turner syndrome., Methods: We collected data of patients between 2012 and 2018 from a single center retrospectively. The study analyzed 36 mosaic Turner syndrome patients, of whom, 10 patients were evaluated as high, 26 patients were evaluated as low-grade mosaic pattern for Turner syndrome., Results: Mean age (35,46±0,87 vs. 36,2 ± 1,85) body mass index (25,26±0,74 vs. 30,8 ± 0,63) baseline follicle stimulating hormone (5,73±0,74 vs. 6,70±1,17) basal luteinizing hormone (4,78±0,43 vs. 4,92±0,99) were similar between two groups. In the high-grade mosaic Turner Syndrome patients, duration of stimulation (7,60±0,16 vs. 8,0 ± 0,28, p<0,001), total gonadotrophin dose (1540,0 ± 165,12 vs. 2046,15± 111,47, p<0,001) and the number of normal karyotype embryos was statistically significantly higher (1,58±0,17 vs. 2,00±0,55, p<0,001). The Pregnancy rates in the low-grade and high-grade mosaic Turner syndrome patients' cycles were 30,8% versus 30%, (p = 0.76) respectively. IVF results were also evaluated by the presence of triploidy were accompanying Turner syndrome or not. In the presence of one or 2 X chromosomes, none of the included in the study could achieve live birth. The most common abnormality in the embryos was monosomy and trisomy of the chromosome13. In 30% of the cases, there were 2 or 3 abnormalities present together. In embryos with 2 abnormal chromosomes, the most common 2 abnormalities were monosomy 13 and trisomy 21, while trisomy 13, trisomy X and monosomy 18 were found in 3 or more abnormalities, respectively., Conclusion: In vitro fertilization and Preimplantation genetic diagnose should be considered in the infertility treatment of the patient with mosaic Turner Syndrome., Competing Interests: Declaration of Competing Interest The authors declare that no conflict of interest, (Copyright © 2022 Elsevier Masson SAS. All rights reserved.)

Published
2022
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48. The effect of hysteroscopy and conventional curretage versus no hysteroscopy on live birth rates in recurrent in vitro fertilisation failure: a retrospective cohort study from a single referral centre experience.

Author

Acet F, Sahin G, Goker ENT, and Tavmergen E

Subjects
Embryo Implantation, Endometrium pathology, Endometrium surgery, Female, Humans, Hysteroscopy methods, Live Birth, Pregnancy, Pregnancy Rate, Referral and Consultation, Retrospective Studies, Birth Rate, Fertilization in Vitro methods
Abstract

This retrospective cohort study aimed to evaluate the effect of hysteroscopy and endometrial scratching (ES) in patients with recurrent implantation failure (RIF) who do not have an intracavity pathology. The authors retrospectively collected data of patients between 2014 and 2019 from a single centre. The study analysed 350 unexplained RIF patients, of whom, 225 underwent hysteroscopy and endometrial scratching, and 125 did not have a hysteroscopy prior to an IVF cycle. Pregnancy rates among post endometrial scratching and no endometrial scratching cycles were 35.6% versus 27.2%, ( p  = .048), clinical pregnancy rates were 32.9% versus 21.6% ( p  = .026) and live birth rates were 26.2% versus 19.2% ( p  = .039). Although it is not possible to distinguish whether hysteroscopy or injury is effective in improving live birth results, the authors thought that endometrial injury with gentle conventional curettage is effective in patients with recurrent implantation failure.IMPACT STATEMENT What is already known on this subject? Hysteroscopy and endometrial injury improve pregnancy outcomes in IVF cycles, but definitive conclusions have been uncertain. What do the results of this study add? The study showed that endometrial injury with gentle conventional curettage during hysteroscopy significantly improved the pregnancy rates of RIF patients compared to the non-hysteroscopy group. What are the implications of these findings for clinical practice and/or further research? In cases of recurrent implantation failure, even if hysteroscopy findings are normal, endometrial scratching in the follicular phase increases pregnancy rates compared to the non-hysteroscopy group.

Published
2022
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49. Evaluating the role of endometrial colour Doppler dynamic tissue perfusion measurements in in vitro fertilisation success.

Author

Akgün Kavurmacı S, Şahin G, Akdoğan A, Yeniel AÖ, Acet F, Tavmergen E, and Göker ENT

Subjects
Color, Embryo Implantation, Female, Humans, Perfusion, Pilot Projects, Prospective Studies, Ultrasonography, Doppler, Color, Endometrium diagnostic imaging, Fertilization in Vitro methods
Abstract

The role of uterine receptivity and endometrial perfusion in in vitro fertilisation (IVF) remains unclear. In our prospective pilot study, we used a new dynamic tissue perfusion measurement method to evaluate this relationship in humans. A standard ovulation induction and embryo transfer method were applied to all the volunteers. On the day of embryo transfer, dynamic images of the uterus were recorded using colour Doppler ultrasound, and these images were uploaded onto PixelFlux Chameleon Software (GmbH, Münster, Germany). After determining the region of interest (ROI), the average velocity, intensity, and area values for all coloured pixels in the ROI, the tissue resistance index (RI) and the tissue pulsatility index were calculated. Endometrial thickness, morphology and dynamic endometrial perfusion parameters were compared between the clinically pregnant and non-pregnant groups. Endometrial thickness, morphology values and endometrial dynamic tissue perfusion measurements were similar between the groups. This study compared perfusion parameters between clinically pregnant and non-pregnant patients by accurately calculating endometrial tissue perfusion using standard software to establish its relationship with implantation success in IVF treatment.IMPACT STATEMENT What is already known about this subject? The relationship between IVF success, endometrial receptivity and perfusion is known. Clear valuations of endometrial receptivity require an endometrial biopsy which may cause endometrial damage to the actual IVF cycle. This problem has led researchers to conduct non-interventional studies. Studies have revealed the value of endometrial thickness, pattern and Doppler examination of endometrial uterine arteries in predicting the success of IVF treatment. What do the results of this study add? This prospective pilot study is the first one to use this programme in humans to evaluate uterine receptivity in IVF. Successful results can be obtained by using computer programmes in tissues where perfusion parameters cannot be measured using traditional colour Doppler ultrasonography. Revealing the relationship between tissue perfusion and IVF success will be more effective and accurate with the development of software technologies. What are the implications of these findings for clinical practice and/or further research? To increase the success of IVF treatment, current and new technological developments, as well as imaging methods should continue to be tested.

Published
2022
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50. Controlled ovarian stimulation outcomes of fertility preservation procedures in newly diagnosed breast cancer patients: a retrospective study from a single-tertiary-IVF centre.

Author

Sahin G, Goker ENT, Gokmen E, Yeniay L, Acet F, Zekioglu O, and Tavmergen E

Subjects
Cryopreservation methods, Female, Fertilization in Vitro methods, Humans, Oocyte Retrieval, Oocytes, Ovulation Induction methods, Pregnancy, Retrospective Studies, Breast Neoplasms surgery, Fertility Preservation methods
Abstract

The aim of this study was to evaluate the effectiveness of controlled ovarian stimulation (COS) using the letrozole-supplemented stimulation protocol in breast cancer (BC) patients prior to their cancer treatment. Sixty-one BC patients (Stages 0-3) who were referred to a university IVF unit for fertility preservation (FP) and underwent embryo and/or oocyte cryopreservation between 2008 - 2020 were included in this retrospective study. Time intervals between breast surgery and initial fertility consultation (IFC)/completion of FP procedures were evaluated. COS outcomes were assessed and compared between the early follicular phase (EFP) and the random-start (RS) protocols. The patients' mean age was 33.3 ± 4.9 years. The mean time interval between breast surgery and IFC was 20.6 ± 11 (day, mean ± SD) and from IFC to completion of FP procedure was 14.7 ± 5.3. Overall, 9.1 ± 5.9 mature oocytes were obtained, with a peak serum oestradiol level of 388 ± 358 pg/mL. The number of oocytes obtained (11.5 ± 9.3 vs. 10.9 ± 6.9, p  = .9) and maturation rates (84.3 ± 17.5% vs. 89.2 ± 11.7, p  = .5) were not statistically different between the EPF and RS protocols. The study results support that oocyte or embryo freezing can be performed effectively in a limited time period with letrozole-supplemented COS protocols before the initiation of oncological treatments in breast cancer patients.Impact statement What is already known on this subject? Currently, embryo and oocyte freezing are considered the most established fertility preservation (FP) methods for newly diagnosed cancer patients. What do the results of this study add? This study reports the COS outcomes of newly diagnosed breast cancer patients for FP over a period of twelve years from a single IVF unit. The results support that a considerable number of oocytes can be harvested with letrozole-supplemented COS protocol, which appears to be an effective protocol for BC patients. What are the implications of these findings for clinical practice and/or further research? There is a need for additional studies evaluating long-term follow-up of patients with their pregnancy outcomes.

Published
2022
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