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According to existing historiography the coffee house played an important role in the sociabilization of the late seventeenth- and the eighteenth-century bourgeoisie. The assumption in existing historiography is that the bourgeois went to the Dutch coffee houses to socialize, converse about political and ethical issues, and thus achieve personal growth. Sociabilization in the coffeehouses was encouraged by ‘literary socialization’: the conversations were spurred by the bourgeois’ reading of texts and introduced them to literary reading of these texts. In this article, we question this historiography for the case of Amsterdam between 1685 and 1785 by a closer investigation of both literary representations of coffee houses and judicial (notary) sources. Coffee houses often appear as scenes of gambling and violent encounters in the notary archives. Literary representations (plays, diaries) confirm a more dissolute and less civilizing character of the Amsterdam coffee house. Moreover, the number of coffee houses in Amsterdam diminished in the eighteenth century, and literary representations are almost completely absent after 1730. They do not appear in a typical bourgeois novel such as Sara Burgerhart. We conclude that coffee houses did not play the key role in literary socialization and sociabilization previously assumed.

Plastics show the strongest production growth of all bulk materials and are already responsible for 4.5% of global greenhouse gas emissions 1,2. If no new policies are implemented, we project a doubling of global plastic demand by 2050 and more than a tripling by 2100, with an almost equivalent increase in CO 2 emissions. Here we analyse three alternative CO 2 emission-mitigation pathways for the global plastics sector until 2100, covering the entire life cycle from production to waste management. Our results show that, through bio-based carbon sequestration in plastic products, a combination of biomass use and landfilling can achieve negative emissions in the long term; however, this involves continued reliance on primary feedstock. A circular economy approach without an additional bioeconomy push reduces resource consumption by 30% and achieves 10% greater emission reductions before 2050 while reducing the potential of negative emissions in the long term. A circular bioeconomy approach combining recycling with higher biomass use could ultimately turn the sector into a net carbon sink, while at the same time phasing out landfilling and reducing resource consumption. Our work improves the representation of material flows and the circular economy in global energy and emission models, and provides insight into long-term dynamics in the plastics sector.

Contains fulltext : 287797.pdf (Publisher’s version ) (Closed access) Sensory driven activity during early life is critical for setting up the proper connectivity of the sensory cortices. We ask here whether social play behavior, a particular form of social interaction that is highly abundant during postweaning development, is equally important for setting up connections in the developing prefrontal cortex (PFC). Young male rats were deprived from social play with peers during the period in life when social play behavior normally peaks [postnatal day 21-42] (SPD rats), followed by resocialization until adulthood. We recorded synaptic currents in layer 5 cells in slices from medial PFC of adult SPD and control rats and observed that inhibitory synaptic currents were reduced in SPD slices, while excitatory synaptic currents were unaffected. This was associated with a decrease in perisomatic inhibitory synapses from parvalbumin-positive GABAergic cells. In parallel experiments, adult SPD rats achieved more reversals in a probabilistic reversal learning (PRL) task, which depends on the integrity of the PFC, by using a more simplified cognitive strategy than controls. Interestingly, we observed that one daily hour of play during SPD partially rescued the behavioral performance in the PRL, but did not prevent the decrease in PFC inhibitory synaptic inputs. Our data demonstrate the importance of unrestricted social play for the development of inhibitory synapses in the PFC and cognitive skills in adulthood and show that specific synaptic alterations in the PFC can result in a complex behavioral outcome.SIGNIFICANCE STATEMENT This study addressed the question whether social play behavior in juvenile rats contributes to functional development of the prefrontal cortex (PFC). We found that rats that had been deprived from juvenile social play (social play deprivation - SPD) showed a reduction in inhibitory synapses in the PFC and a simplified strategy to solve a complex behavioral task in adulthood. Providing one daily hour of play during SPD partially rescued the cognitive skills in these rats, but did not prevent the reduction in PFC inhibitory synapses. Our results demonstrate a key role for unrestricted juvenile social play in PFC development and emphasize the complex relation between PFC circuit connectivity and cognitive function.

Brain-related comorbidities are frequently observed in chronic obstructive pulmonary disease (COPD) and are related to increased disease progression and mortality. To date, it is unclear which mechanisms are involved in the development of brain-related problems in COPD. In this study, a cigarette smoke and lipopolysaccharide (LPS) exposure murine model was used to induce COPD-like features and assess the impact on brain and behavior. Mice were daily exposed to cigarette smoke for 72 days, except for days 42, 52, and 62, on which mice were intratracheally exposed to the bacterial trigger LPS. Emphysema and pulmonary inflammation as well as behavior and brain pathology were assessed. Cigarette smoke-exposed mice showed increased alveolar enlargement and numbers of macrophages and neutrophils in bronchoalveolar lavage. Cigarette smoke exposure resulted in lower body weight, which was accompanied by lower serum leptin levels, more time spent in the inner zone of the open field, and decreased claudin-5 and occludin protein expression levels in brain microvessels. Combined cigarette smoke and LPS exposure resulted in increased locomotion and elevated microglial activation in the hippocampus of the brain. These novel findings show that systemic inflammation observed after combined cigarette smoke and LPS exposure in this COPD model is associated with increased exploratory behavior. Findings suggest that neuroinflammation is present in the brain area involved in cognitive functioning and that blood-brain barrier integrity is compromised. These findings can contribute to our knowledge about possible processes involved in brain-related comorbidities in COPD, which is valuable for optimizing and developing therapy strategies.

Genetically controlled broad-spectrum disease resistance is a highly desired trait for crop improvement. It allows to reduce the use of pesticides in the field and helps to streamline the development of new varieties. More than 100 loci are known to control the resistance of rice (Oryza sativa) to the devastating fungal blast disease caused by Magnaporthe oryzae. Some of these loci are effective against a small set of pathogen isolates, while others protect against a broader range of pathogen variants (Ning et al., 2020).

Objective: A fixed 6 mg dexamethasone dose for 10 days is the standard treatment for all hospitalised COVID-19 patients who require supplemental oxygen. Yet, the pharmacokinetic properties of dexamethasone can lead to diminishing systemic dexamethasone exposure with increasing body mass index (BMI). The present study examines whether this translates to overweight and obesity being associated with worse clinical outcomes, defined as ICU admission or in hospital death, in COVID-19 patients treated with fixed-dose dexamethasone. Methods: We conducted a single centre retrospective cohort study in COVID-19 patients who were admitted to a non-ICU ward and were treated with dexamethasone (6 mg once daily for a maximum of ten days) between June 2020 and January 2021. Univariable and multivariable logistic regression analyses were conducted to assess the association between BMI-categories and an unfavourable clinical course (ICU admission and/or in hospital death). Analyses were adjusted for age, comorbidities, inflammatory status, and oxygen requirement at admission. For reference, similar analyses were repeated in a cohort of patients hospitalised before dexamethasone was introduced (March 2020 through May 2020). Results: In patients treated with dexamethasone (n = 385) an unfavourable clinical course was most prevalent in patients with normal weight (BMI < 25) compared to patients with overweight (BMI 25–30) and patients with obesity (BMI ≥ 30) with percentages of 33, 26 and 21% respectively. In multivariable analyses, there was no association between BMI-category and an unfavourable clinical course (respectively with aORs of 0.81 (0.43–1.53) and 0.61 (0.30–1.27) with normal weight as reference). In the reference cohort (n = 249) the opposite was observed with an unfavourable clinical course being most prevalent in patients with overweight (39% vs 28%; aOR 2.17 (0.99–4.76)). In both cohorts, CRP level at admission was higher and lymphocyte count was lower in patients with normal weight compared to patients with obesity. Conclusions: Overweight and obesity are not associated with an unfavourable clinical course in COVID-19 patients admitted to a non-ICU ward and treated with 6 mg dexamethasone once daily.

Our study focuses on myths about older people’s smartphone use. Self-reported data, from Eurostat for example, report access rather than actual usage and are of limited use. What respondents report does not necessarily correspond with their actual smartphone usage behaviour in everyday life. We therefore conducted a tracking study to gain insight into smartphone usage among older adults. Smartphone activity logs were collected from individuals aged 60–79 (N = 303) throughout a period of 28 days between February and May 2019 in Canada, the Netherlands, Spain and Sweden. The data thus obtained on actual smartphone use were critically examined in the light of seven myths related to the smart phone usage of older people in everyday life. We also analysed the data in the context of empirical studies in the field of older people’s digital behaviour. Finally, after drawing our conclusions, we present limitations and sketch implications for future research.

De stelling in deze aflevering van TvCR luidt: ‘In de zaak Gündoğan/Volt wreekte zich het ontbreken van een fatsoenlijke wettelijke regeling over het functioneren van Kamerfracties.’ Max Vetzo pleit tegen deze stelling. Volgens hem schuilt het probleem niet in het ontbreken van objectieve wettelijke normen, maar in institutionele onduidelijkheid over de vraag welke rol de rechter in geschillen over het fractielidmaatschap van Kamerleden toekomt.

Motivation lies at the core of human behavior. It explains why we do what we do. In this article, we seek an explanation for the influence of leadership, purpose, and values on employee engagement through motivation. Engaged employees derive energy from their work, are dedicated, show higher psychological well-being, and perform better. We suspected that motivation, as defined in self-determination theory, is an underlying mechanism that could explain the relationship between leadership and positive outcomes. To this end, we con-ducted five empirical studies in which the fulfillment of the basic psychological needs for autonomy, competence, and connectedness played a central role. We found that engaging leadership, a higher corporate purpose, and intrinsic values stimulated motivation and engagement. The fulfilment of psychological needs (notably autonomy) played an important role in these relationships. A sixth study tested leadership and inspiration in an intervention study. The intervention led to higher motivation among participants, lower absenteeism among employees, and better business performance. Navigating motivation at work supports employees to flourish, develop, and find significance.

AIM: The objective of this study was to describe the use of COVID-19-related medicines during pregnancy and their evolution between the early/late periods of the pandemic. METHODS: Pregnant women who tested positive for SARS-CoV-2 from March 2020 to July 2021 were included using the COVI-PREG registry. Exposure to the following COVID-19-related medicines was recorded: antibiotics, antivirals, hydroxychloroquine, corticosteroids, anti-interleukin-6 and immunoglobulins. We described the prevalence of medicines used, by trimester of pregnancy, maternal COVID-19 severity level and early/late period of the pandemic (before and after 1 July 2020). FINDINGS: We included 1964 pregnant patients who tested positive for SARS-CoV-2. Overall, 10.4% (205/1964) received at least one COVID-19-related medicine including antibiotics (8.6%; 169/1694), corticosteroids (3.2%; 62/1964), antivirals (2.0%; 39/1964), hydroxychloroquine (1.4%; 27/1964) and anti-interleukin-6 (0.3%; 5/1964). The use of at least one COVID-19-related medicine was 3.1% (12/381) in asymptomatic individuals, 4.2% (52/1233) in outpatients, 19.7% (46/233) in inpatients without oxygen, 72.1% (44/61) in those requiring standard oxygen, 95.7% (22/23) in those requiring high flow oxygen, 96.2% (25/26) in patients who required intubation and 57.1% (4/7) among patients who died. The proportion who received medicines to treat COVID-19 was higher before than after July 2020 (16.7% vs. 7.7%). Antibiotics, antivirals and hydroxychloroquine had lower rates of use during the late period. CONCLUSION: Medicine use in pregnancy increased with disease severity. The trend towards increased use of corticosteroids seems to be aligned with changing guidelines. Evidence is still needed regarding the effectiveness and safety of COVID-19-related medicines in pregnancy.

The aim of this work was to evaluate the seasonal effect on the metabolomic profile of the ovarian follicle in Italian Mediterranean buffalo to unravel the causes of the reduced competence during the non-breeding season (NBS). Samples of follicular fluid, follicular cells, cumulus cells and oocytes were collected from abattoir-derived ovaries during breeding season (BS) and NBS and analyzed by 1H Nuclear Magnetic Resonance. The Orthogonal Projections to Latent Structures of the Discriminant Analysis showed clear separation into seasonal classes and Variable Importance in Projection method identified differentially abundant metabolites between seasons. Seasonal differences were recorded in metabolite content in all analyzed components suggesting that the decreased oocyte competence during NBS may be linked to alteration of several metabolic pathways. The pathway enrichment analysis revealed that differences in the metabolites between the seasons were linked to glutathione, energy generating and amino acid metabolism and phospholipid biosynthesis. The current work allows the identification of potential positive competence markers in the follicular fluid as glutathione, glutamate, lactate and choline, and negative markers like leucine, isoleucine and β-hydroxybutyrate. These results form a major basis to develop potential strategies to optimize the follicular environment and the IVM medium to improve the competence of oocytes during the NBS.

Epidemiological studies indicate that chronic obstructive pulmonary disease (COPD) is associated with the incidence of changes in intestinal health. Cigarette smoking, as one of the major causes of COPD, can have an impact on the gastrointestinal system and promotes intestinal diseases. This points to the existence of gut-lung interactions, but an overview of the underlying mechanisms of the bidirectional connection between the lungs and the gut in COPD is lacking. The interaction between the lungs and the gut can occur through circulating inflammatory cells and mediators. Moreover, gut microbiota dysbiosis, observed in both COPD and intestinal disorders, can lead to a disturbed mucosal environment, including the intestinal barrier and immune system, and hence may negatively affect both the gut and the lungs. Furthermore, systemic hypoxia and oxidative stress that occur in COPD may also be involved in intestinal dysfunction and play a role in the gut-lung axis. In this review, we summarize data from clinical research, animal models, and in vitro studies that may explain the possible mechanisms of gut-lung interactions associated with COPD. Interesting observations on the possibility of promising future add-on therapies for intestinal dysfunction in patients with COPD are highlighted.

Epidemiological studies indicate that chronic obstructive pulmonary disease (COPD) is associated with the incidence of changes in intestinal health. Cigarette smoking, as one of the major causes of COPD, can have an impact on the gastrointestinal system and promotes intestinal diseases. This points to the existence of gut-lung interactions, however, an overview of the underlying mechanisms of the bidirectional connection between the lungs and the gut in COPD is lacking. The interaction between the lungs and the gut can occur through circulating inflammatory cells and mediators. Moreover, gut microbiota dysbiosis, observed in both COPD and intestinal disorders, can lead to a disturbed mucosal environment, including the intestinal barrier and immune system, and hence, may negatively affect both the gut and the lungs. Furthermore, systemic hypoxia and oxidative stress that occurs in COPD may also be involved in intestinal dysfunction and play a role in the gut-lung axis. This review summarizes data from clinical research, animal models and in vitro studies that may explain the possible mechanisms of gut-lung interactions associated with COPD. Interesting observations on the possibility of promising future add-on therapies for intestinal dysfunction in COPD patients will be highlighted.

Adaptation is a key societal response to reduce the impacts of climate change, yet it is poorly represented in current modelling frameworks. We identify key research gaps and suggest entry points for adaptation in quantitative assessments of climate change to enhance policy guidance.

Sustainable ecosystem management relies on our ability to predict changes in plant diversity and to understand the underlying mechanisms. Empirical evidence demonstrates that abundance- and functional-based processes simultaneously explain the loss of plant diversity in response to human activities. Recently, a novel indicator based on percent cover (CoverD) and maximum height (HeightD) of the dominant plant species – space resource utilization (SRUD) – has proven to give robust and better predictions of plant diversity dynamics than community biomass. Whether the superior predictive ability of SRUD is due to its capacity to simultaneously capture abundance- and functional-based processes remains unknown. Here, we tested this hypothesis by quantifying mechanistic links between changes in SRUD and biodiversity in response to nutrients and herbivores. Furthermore, we assessed the relative contribution of dominant, intermediate and rare species to reduced density of individuals by combining null model analysis with field experiments. We found that SRUD successfully captured changes in ground-level light availability and changes in the number of individuals to predict plant diversity dynamics, and each of CoverD and HeightD partly and independently contributed to both processes. Comparative results from null model analysis and field experiments confirmed that individual losses of dominant, intermediate and rare species followed non-random processes. Specifically, compared with random loss process, rare species lost proportionally more individuals and thus disproportionately contributed to species loss, while dominant and intermediate species lost less. Our results demonstrate that SRUD captures both abundance- and functional-based processes thus explaining why SRUD provides more accurate predictions of changes in species diversity. Given that rare species can play an important role in shaping community structure, resisting against invasion, impacting higher trophic levels and providing multiple ecosystem functions, reducing the SRU of dominant species could alleviate the risk of exclusion of rare species by mitigating abundance- and functional-based competition processes.

How we can accelerate the diffusion of new clean energy technologies worldwide is a highly relevant topic for energy and climate policies, as well as industrial policies. We trace the time lag between the introduction and the diffusion of breakthroughs in solar photovoltaic technology and wind power technology. Our results show that both domestic knowledge base and organizational proximity to the country introducing breakthroughs, help latecomer countries catch up by actively innovating in these technologies on their own. Moreover, we find that there are more opportunities for latecomer countries with stronger domestic knowledge base to catch up in solar photovoltaic technology than wind power technology. The results of this paper provide systematic evidence of the technology-sensitive catching-up process in the clean energy technological paradigm.

More than 100 countries have communicated or adopted new Nationally Determined Contributions (NDCs) and net-zero target pledges. We investigate the impact on global, national, sectoral, and individual greenhouse gas emissions projections under different scenarios based on the announced NDCs and net-zero pledges using the IMAGE integrated assessment model. Our results show that while the net-zero pledges, if implemented, could be an important step forward, they are still not enough to achieve the Paris Agreement goals of well below 2°C and preferably 1.5°C by the end of the century. Still, our net-zero scenarios project significant all-sector decarbonization, in particular, electricity; however, certain sectors like industry and transport prove hard to completely abate.

In an attempt to explore further the Madelung fluid-like representation of quantum mechanics, we derive the small perturbation equations of the fluid with respect to its basic states. The latter are obtained from the Madelung transform of the Schrödinger equation eigenstates. The fundamental eigenstates of de Broglie monochromatic matter waves are then shown to be mapped into the simple basic states of a fluid with constant density and velocity, where the latter is the de Broglie group velocity. The normal modes with respect to these basic states are derived and found to also satisfy the de Broglie dispersion relation. Despite being dispersive waves, their propagation mechanism is equivalent to that of sound waves in a classical ideal adiabatic gas. We discuss the physical interpretation of these results.

INTRODUCTION: Adherence to anticancer agents is a critical factor in achieving adequate clinical response, and became a major challenge for patients and caregivers since the increased substitution of parenteral cytostatic by oral drugs. One of the factors that influences adherence is how well informed patients are about their therapy. This study assesses the association between patient satisfaction with information about oral anticancer agents and adherence. MATERIALS AND METHODS: This study was conducted among patients (≥18 years) who began oral anticancer therapy. Patients satisfaction with information and adherence were assessed using validated questionnaires. Adherence was also assessed using refill data. Logistic regression was applied to assess the association between overall patient satisfaction with information and both self-reported adherence and adherence based on an MPR value of above 80%. RESULTS: In total, 124 patients were included in the study. The median (IQR) satisfaction with information was 15.0(4) on a scale of 0-17. Eighty-two percent of participants reported adherence, while the refill data demonstrated that 64.5% of patients had an adherence rate of 80% or higher. Overall satisfaction with information was not significantly associated with self-reported adherence (OR adj 0.98 [95% CI 0.85-1.15]) or refill-based adherence (OR adj 1.11 [95% CI 0.99-1.24]). CONCLUSION: The findings indicate no significant relationship between patient satisfaction with information and adherence. The population was highly satisfied with information about the oral anticancer agents, which indicates a high level of satisfaction with usual care. However, the refill data reveals that 35.5% of patients were not adherent.

We generalize the greedy and lazy $\beta$-transformations for a real base $\beta$ to the setting of alternate bases $\boldsymbol{\beta}=(\beta_0,\ldots,\beta_{p-1})$, which were recently introduced by the first and second authors as a particular case of Cantor bases. As in the real base case, these new transformations, denoted $T_\boldsymbol{\beta}$ and $L_\boldsymbol{\beta}$ respectively, can be iterated in order to generate the digits of the greedy and lazy $\boldsymbol{\beta}$-expansions of real numbers. The aim of this paper is to describe the dynamical behaviors of $T_\boldsymbol{\beta}$ and $L_\boldsymbol{\beta}$. We first prove the existence of a unique absolutely continuous (with respect to an extended Lebesgue measure, called the $p$-Lebesgue measure) $T_\boldsymbol{\beta}$-invariant measure. We then show that this unique measure is in fact equivalent to the $p$-Lebesgue measure and that the corresponding dynamical system is ergodic and has entropy $\frac{1}{p}\log(\beta_{p-1}\cdots \beta_0)$. We then express the density of this measure and compute the frequencies of letters in the greedy $\boldsymbol{\beta}$-expansions. We obtain the dynamical properties of $L_\boldsymbol{\beta}$ by showing that the lazy dynamical system is isomorphic to the greedy one. We also provide an isomorphism with a suitable extension of the $\beta$-shift. Finally, we show that the $\boldsymbol{\beta}$-expansions can be seen as $(\beta_{p-1}\cdots \beta_0)$-representations over general digit sets and we compare both frameworks., Comment: 28 pages, 15 figures

De wiskunde en sterrenkunde in de middeleeuwse islamitische wereld hebben grote invloed gehad op de wetenschap in christelijk Europa. Deze invloed is nog steeds te zien aan de Arabische woorden algebra, algoritme, almanak, zenith, nadir en azimuth en aan vele Arabische sterrennamen zoals Rigel, Deneb en Aldebaran. Het aanzien van de exacte wetenschappen in de middeleeuwse islamitische wereld was voor een deel te danken aan het verband tussen wis- en sterrenkunde en islamitische religieuze voorschriften. In dit artikel geven we een paar voorbeelden.

A reflection on the lack of an EU approach of pre-trial detention. There are many ‘success stories’ as to the harmonisation of criminal (procedural) law within the EU, such as the directives on procedural safeguards, that often build upon consistent case-law of the ECtHR. Rules on pre-trial detention are not among these succes stories. On the one hand, the European Arrest Warrant (EAW) has secured, amongst others, a practice in which pre-trial detention can provisionally start in each EU-state, not always with as much judicial scrutiny as a strictly national application of pre-trial detention would require. On the other hand, though, attempts to harmonise national rules on pre-trial detention – and, e.g., promote the use of alternatives for a detention order – so far have failed. This seems odd, as the ECHR and the ECtHR’s case-law on pre-trial detention has been consistent as well and harmonising rules and procedure in this regard would have made sense. In the following, I will shortly point at important aspects of the ECtHR case-law that could be the starting point of such harmonisation (para. 2), after which I will look back in time as I go into the development of the Corpus Juris, which tried to introduce a provision on pre-trial detention in the EU legislation. I will then show that this part of the Corpus Juris has not been followed up (contrary to some important other features) (para. 4) and that up until today, those striving for minimum rules on pre-trial detention in the EU are disenchanted (para. 5).

Declines in grassland diversity in response to nutrient addition are a general consequence of global change. This decline in species richness may be driven by multiple underlying processes operating at different time-scales. Nutrient addition can reduce diversity by enhancing the rate of local extinction via competitive exclusion, or by reducing the rate of colonization by constraining the pool of species able to colonize under new conditions. Partitioning net change into extinction and colonization rates will better delineate the long-term effect of global change in grasslands. We synthesized changes in richness in response to experimental fertilization with nitrogen, phosphorus and potassium with micronutrients across 30 grasslands. We quantified changes in local richness, colonization, and extinction over 8–10 years of nutrient addition, and compared these rates against control conditions to isolate the effect of nutrient addition from background dynamics. Total richness at steady state in the control plots was the sum of equal, relatively high rates of local colonization and extinction. On aggregate, 30%–35% of initial species were lost and the same proportion of new species were gained at least once over a decade. Absolute turnover increased with site-level richness but was proportionately greater at lower-richness sites relative to starting richness. Loss of total richness with nutrient addition, especially N in combination with P or K, was driven by enhanced rates of extinction with a smaller contribution from reduced colonization. Enhanced extinction and reduced colonization were disproportionately among native species, perennials, and forbs. Reduced colonization plateaued after the first few (

The effects of home visiting programs to reduce child maltreatment are generally limited and warrant improvement. The present study, therefore, examined whether the effectiveness of a home visitation program in the Netherlands can be improved by adding specific intervention components targeting important risk factors for child maltreatment, namely parental stress, parental anger, and PTSD symptoms. Using a single-case experimental design, nine mothers were assessed weekly during 36 weeks of the Dutch home visiting program VoorZorg, comparing baseline, treatment (i.e., phase with added intervention components), and follow-up. Outcome effects were examined using statistical analyses on a group level and combining statistical and visual analyses on a case level for primary outcomes: perceived stress, parental anger, and PTSD symptoms, and secondary outcomes: risk of child maltreatment and parental sense of competence. As a group, mothers showed a reduction of anger in response to the additional components. No group effects were found for other outcomes. At an individual level, three mothers showed only positive effects, four mothers showed no intervention effects, and two mothers showed mixed effects (i.e., positive on some outcomes and negative on other). Consequently, the component targeting parental anger seems promising, because it can easily be implemented, but it is important to prevent any possible detrimental effects. Effects of the component targeting stress depended on the use of relaxation exercises, and therefore this component should be expanded in such a way that it is more feasible for mothers to implement it.

Our planet is rapidly urbanizing. Research has recognized the complexity of city-driven dynamics, but our political realities have yet to catch up. A new narrative of sustainable urban development must become central to global policymaking to help humanity respond to the most pressing social and environmental challenges.

The primary objective of this study was to investigate the beneficial effects of seed priming and foliar spray of potassium silicate on antioxidant activities under different salinity levels, thereby potentially improving wheat growth. Seeds were soaked into solutions containing potassium silicate (K2SiO3, 1.5 mM) for 6 h, while foliar spray with K2SiO3 (4 mM) was applied at the early and the late stages of tillering. Lake Urmia water was used to prepare salinity levels of 0, 3, 5, 8, 10, 12, and 14 dS m −1. For such traits as anthocyanin, catalase, ascorbate peroxidase, guaiacol peroxidase, and superoxide dismutase activity, an initial increase was observed at lower salinity levels; higher salinities subsequently decreased these traits or they remained mostly constant. Salinity also increased phenol, malondialdehyde, hydrogen peroxide, and polyphenol oxidase, but decreased flavonoid, nitrate content, and nitrate reductase activity. Seed priming and foliar spray provided effective approaches to reduce reactive oxygen species (ROS) manifestation in wheat grown under saline conditions. The improved antioxidant defense abilities by seed priming and foliar spray alleviated the oxidative damage of proteins and lipids and improved nitrate content and nitrate reductase activity.

Purpose: Population-based studies on treatment patterns in oncology and corresponding clinical outcomes can help identify strategies towards optimal value for patients. This study was performed to describe the variation in treatment patterns and major oncological outcomes for muscle-invasive or metastatic bladder cancer (MIBC/mBC) patients in the Netherlands. Methods: Patients diagnosed with cT2-4aN0-3M0-1 disease between 2008 and 2016 in seven large teaching hospitals in the Netherlands were included. Baseline characteristics, disease stage, intended and definitive treatment, and oncological outcomes were collected. Patients were categorized based on cTNM-stage: (1) cT2-4aN0M0, (2) cT2-4aN1-3M0 and (3) cT4b and/or M1. Results: The total study population comprised 1853 patients, of which 1303 patients were diagnosed with cT2-4aN0M0 disease. Overall, curative treatment was intended in 81% (range 74–85%, P value = 0.132). Radical cystectomy (RC) and curative radiotherapy (RTx) ranged between hospitals from 42 to 66% and 13 to 27%, respectively (P value < 0.001). For 334 patients staged cT4b and/or M1, frequencies for palliative therapy and best supportive care (no anti-cancer therapy) ranged between hospitals from 20 to 54% and 44 to 71%, respectively (P value < 0.001). There was no association between hospital site and overall survival (OS) in a univariable and multivariable Cox regression for survival analysis (after adjusting for age and cT-stage), for all three cTNM-groups. Neoadjuvant or induction chemotherapy (NAIC) utilization rates before RC ranged from 8 to 38% (P value < 0.001). Conclusions: There is large inter-hospital variation in treatment intent in MIBC/mBC patients. This variation does not seem to translate to differences in overall survival rates. There is an ongoing trend of increased use of RC. Utilisation of NAIC is relatively low considering European guideline recommendations.

Evidence suggests an impact of the COVID-19 pandemic on mental health, particularly among emerging adults. However, theories on altruism born of suffering or adversarial growth suggest that we might also see prosocial behavior as a function of the pandemic, which may protect against mental health challenges. Because cultural values are central in determining prosocial behavior, the current study explored how cultural values were differentially associated with adaptive prosocial behaviors that might protect against mental health challenges. Participants for the current study included 5,682 young people aged 18–25 years from 14 different countries around the world (68% female, 62% college students). Path analyses suggested that there were few differences in patterns as a function of culture, but revealed that horizontal individualism and horizontal and vertical collectivism were indirectly associated with lower levels of depression via prosocial behavior toward family members. Discussion focuses on the importance of coping by strengthening family relationships via prosocial behavior during the pandemic.

Protein aggregates are hallmarks of neurodegenerative diseases. The protein quality control (PQC) system normally prevents proteins from misfolding and accumulation; however, proteins somehow escape this control on disease. Here we review advances in the role of PQC in protein aggregation and neurodegeneration. We focus primarily on the protein Tau, which aggregates in Alzheimer's disease (AD) and other tauopathies. We also examine recent advances in amyloid fibril structures and the process of fibril formation via phase separation, which are shedding new light on the role of PQC in protein aggregation diseases. While specific components of the quality control system appear to be altered in disease, most chaperones and degradation factors are unchanged at the cellular end stage. Advancing the understanding of quality control factors in neurodegeneration, particularly in the early stages of disease, is among the key challenges for neurodegeneration research.

Whether the use of industrial wood pellets for bioenergy is part of the problem of climate change or part of the solution to climate change has been heavily debated in the academic and political arena. The uncertainty around this topic is impeded by contradicting scientific assessments of carbon impacts of wood pellet use. Spatially explicit quantification of the potential carbon impacts of increased industrial wood pellet demand, including both indirect market and land-use change effects, is required to understand potential negative impacts on carbon stored in the landscape. Studies that meet these requirements are scarce. This study assesses the impact of increased wood pellet demand on carbon stocks in the landscape in the Southern US spatially explicitly and includes the effects of demand for other wood products and land-use types. The analysis is based on IPCC calculations and highly detailed survey-based biomass data for different forest types. We compare a trend of increased wood pellet demand between 2010 and 2030 with a stable trend in wood pellet demand after 2010, thereby quantifying the impact of increased wood pellet demand on carbon stocks in the landscape. This study shows that modest increases in wood pellets demand (from 0.5 Mt in 2010 to 12.1 Mt in 2030), compared to a scenario without increase in wood pellet demand (stable demand at 0.5 Mt), may result in carbon stock gains of 103-229 Mt in the landscape in the Southern US. These carbon stock increases occur due to a reduction in natural forest loss and an increase in pine plantation area compared to a stable-demand scenario. Projected carbon impacts of changes in wood pellet demand were smaller than carbon effects of trends in the timber market. We introduce a new methodological framework to include both indirect market and land-use change effects into carbon calculations in the landscape.

Nutrients and herbivores are well-known drivers of grassland diversity and stability in local communities. However, whether they interact to impact the stability of aboveground biomass and whether these effects depend on spatial scales remain unknown. It is also unclear whether nutrients and herbivores impact stability via different facets of plant diversity including species richness, evenness, and changes in community composition through time and space. We used a replicated experiment adding nutrients and excluding herbivores for 5 years in 34 global grasslands to explore these questions. We found that both nutrient addition and herbivore exclusion alone reduced stability at the larger spatial scale (aggregated local communities; gamma stability), but through different pathways. Nutrient addition reduced gamma stability primarily by increasing changes in local community composition over time, which was mainly driven by species replacement. Herbivore exclusion reduced gamma stability primarily by decreasing asynchronous dynamics among local communities (spatial asynchrony). Their interaction weakly increased gamma stability by increasing spatial asynchrony. Our findings indicate that disentangling the processes operating at different spatial scales may improve conservation and management aiming at maintaining the ability of ecosystems to reliably provide functions and services for humanity.

In this review, we evaluate the claim that translanguaging in the classroom supports the development of the bilingual lexicon by enhancing cross-linguistic transfer. To address this issue, we integrate findings from psycholinguistics and educational sciences in order to identify how effective pedagogical practices for monolingual children can be extended to pedagogical practices for bilingual children. We show that both monolingual and bilingual children benefit from teaching strategies that strengthen the mental connections between semantically and phonologically related words, and that for bilingual children, these strategies should support both within- and cross-language connections. We argue that by stimulating the use of the home language in the classroom, translanguaging strategies like multilingual label quests and multilingual reading and writing can strengthen cross-language connections and, thereby, facilitate cross-linguistic lexical transfer. For closely related languages, stimulation of the home language has the additional benefit of implicitly facilitating the transfer of cognate vocabulary. Explicit instruction about cognates could further stimulate the development of cognate awareness, but whether it also enhances vocabulary learning is still an open question.

Dams affect the natural flow regime by altering the magnitude, timing and frequency of high and low flows. Many river ecosystems impaired by dams are currently being restored. Restoration success is difficult to quantify and is often assessed by comparing the restored system to an unimpaired static ‘reference’ system. However, restoring a river to past environmental conditions and assessing restoration success by comparing it to a static situation neglects natural system dynamics and non-linear, adaptive system responses. With this modelling study we evaluate long-term changes in river morphology, morphodynamics, riparian vegetation cover and habitat suitability of two fish species and two types of wetland vegetation in a meandering gravel bed river after removal of an upstream dam and complete restoration of the natural flow regime. We assessed the ecological and hydromorphodynamic recovery of systems impaired by two different dam operating regimes and three different time periods the dam was present by comparing these to a dynamic undisturbed situation. Modelling results show that recovery potential depends on how much the system has been changed by the dam and the system state at the start of the restoration, rather than the duration of the pressure. Even if the conditions shortly after restoration are comparable to pre-disturbance conditions, there can still be a time-lag in the system response where the future state of the restored system continues to deviate from the undisturbed situation. When this happens, the system can develop into an alternative dynamic equilibrium where recovery becomes increasingly difficult. These results stress the importance of considering natural variability in restored systems as well as in reference systems, requiring detailed spatio-temporal monitoring to assess restoration effects.

PurposePA scholars argue that two gaps are present in the stress literature: (1) “stress” is too simply treated as deleterious and (2) insufficient efforts are made to capture public servants' stress appraisal, i.e. the degree to which stressors are appraised as hindering or challenging. Overcoming Gap 1, this study aims to study stress as a continuum; from distress to eustress. Overcoming Gap 2, stress appraisal is studied through testing the interaction of PsyCap with the two most common clusters of public servants' job stressors: emotional and psychological stressors.Design/methodology/approachHypotheses are tested through structural equation modeling. A sample is used in this study of 1,853 Dutch public servants.FindingsThe results show that emotional and psychological stressors are high, but public servants often appraise them as challenging or as “part of the job”, with consequently no increased distress or decreased eustress. Moreover, psychological capital helps public servants to appraise some of the negative effects of emotional, but not psychological, stressors as less deleterious.Originality/valueBy approaching stress as a continuum, the authors bring in a more complete picture of public servants' stress in PA literature. Moreover, this research shows that the ambiguous results in the existing stress literature about the consequences of emotional and psychological stressors on distress/eustress can partially be explained by sector differences as well as personality differences (i.e. PsyCap). Finally, this study criticizes the one-sided attention to PsyCap as purely positive. PsyCap is not only unhelpful in coping with psychological stressors, it also drains the challenging properties of psychological stressors for dedication.

While important for many industrial applications, chemical reactions responsible for charging of solids in water are often poorly understood. We theoretically investigate the charging kinetics of solid-liquid interfaces, and find that the time-dependent equilibration of surface charge contains key information not only on the reaction mechanism, but also on the valency of the reacting ions. We construct a non-linear differential equation describing surface charging by combining chemical Langmuir kinetics and electrostatic Poisson-Boltzmann theory. Our results reveal a clear distinction between late-time (near-equilibrium) and short-time (far-from-equilibrium) relaxation rates, the ratio of which contains information on the charge valency and ad- or desorption mechanism of the charging process. Similarly, we find that single-ion reactions can be distinguished from two-ion reactions as the latter show an inflection point during equilibration. Interestingly, such inflection points are characteristic of autocatalytic reactions, and we conclude that the Coulombic ion-surface interaction is an autocatalytic feedback mechanism., Comment: 6 pages, 2 figures, Supplemental Material: 4 pages, 2 figures

Group history provides the experiential building blocks that shape social identity. When contemporary events are perceived as having created (or creating) a discontinuity with that history, collective nostalgia is likely to be elicited. Importantly, collective nostalgia is functional-it consolidates social identity, motivating group members to support a return to the group's "true" state of existence. However, no group is a monolith. Factions within a group may have differing opinions on what aspects of the past best represent core features of the ingroup. Variations in the content of the collective nostalgia can cleavage members' responses. Herein, we review research demonstrating the powerful role collective nostalgia and its contents play in intra- and intergroup relations, especially in the socio-political domain.

A recent article in this journal (Jackson 2021) validly emphasized that debates about the Anthropocene need to recognize a diverse range of perspectives, worldviews, and forms of knowledge. In doing so, however, the author mischaracterized scholarship on earth system governance as being antithetical to a critical and pluralistic stance on the Anthropocene. In this commentary we address key concerns about the article: selective and misleading quotations regarding the earth system governance literature’s diversity; unwarranted insinuations that juxtapose the implications of this literature with those of slavery and holocausts; and neglect of the breadth and diversity of scholarship on earth system governance. We underscore the need for scholarly debates on the Anthropocene to be informed by a balanced and rigorous assessment of existing scholarship, and for a constructive dialogue between global and locally situated ways of understanding the earth.

Although the destabilizing effects of biodiversity loss on ecosystem functioning at local and larger spatial scales are fairly well understood, the consequences of environmental homogenization have received much less attention. Based on detailed measurements of permanent natural forest plots distributed over a large temperate forest region, we explored the effects of environmental heterogeneity and biodiversity on ecosystem stability at local and larger spatial scales. Our results show that the relationship between environmental heterogeneity and biodiversity, as well as between environmental heterogeneity and stability across scales are mostly nonlinear, and that biodiversity stabilizes ecosystem functioning in these natural forests across scales. The unique contribution of biodiversity to stabilizing ecosystem functioning from local to larger scales is greater than the heterogeneity of climate, soils, topography, vegetation, and land cover. To our knowledge, this study is the first to quantify the effects of environmental heterogeneity on the temporal stability of forest productivity in a large natural forest region. Our results imply that biodiversity contributes to stabilizing forest ecosystems from local to larger spatial scales as much as environmental heterogeneity. Research involving large heterogeneous landscapes is critical to understanding the ecological effects of biodiversity across scales. The results of this study are thus relevant for developing effective conservation and land management strategies.

Our planet is rapidly urbanizing. Research has recognized the complexity of city-driven dynamics, but our political realities have yet to catch up. A new narrative of sustainable urban development must become central to global policymaking to help humanity respond to the most pressing social and environmental challenges.

Objectives Most currently available medication self-management support tools do not meet the needs of patients with limited health literacy. Recently, tools that are better tailored to the needs of patients with limited health literacy have been developed. This study aimed to assess the usability of an animated diabetes information tool by patients with diabetes with limited and adequate health literacy levels. Methods Participants with limited and adequate health literacy levels were selected based on three health literacy questions in a screening interview, and asked to use the tool three times a week, after which individual semistructured interviews were conducted. The interview topics were based on the technology acceptance model (i.e. perceived ease of use, perceived usefulness, and intention to use). Twenty-five patients with diabetes were included in the study. Key findings All participants perceived the tool as easy to use due to a clear overview of topics and only personalized information being provided. Those with limited health literacy indicated that they had learned from the tool and had the intention to continue using it in the future. These participants also expressed the need for the tool to be more actively offered by healthcare professionals, while participants with adequate health literacy expressed the need for more in-depth information. Conclusion The tailored self-management support tool was perceived as usable by all participants. To better serve them, the tool could be further improved by addressing the additional needs of people with limited as well as adequate health literacy.