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244 results on '"Tavangar, SM"'

1. Global burden of 288 causes of death and life expectancy decomposition in 204 countries and territories and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021

Author: Naghavi, M, Ong, KL, Aali, A, Ababneh, HS, Abate, YH, Abbafati, C, Abbasgholizadeh, R, Abbasian, M, Abbasi-Kangevari, M, Abbastabar, H, Abd ElHafeez, S, Abdelmasseh, M, Abd-Elsalam, S, Abdelwahab, A, Abdollahi, M, Abdollahifar, M-A, Abdoun, M, Abdulah, DM, Abdullahi, A, Abebe, M, Abebe, SS, Abedi, A, Abegaz, KH, Abhilash, ES, Abidi, H, Abiodun, O, Aboagye, RG, Abolhassani, H, Abolmaali, M, Abouzid, M, Aboye, GB, Abreu, LG, Abrha, WA, Abtahi, D, Abu Rumeileh, S, Abualruz, H, Abubakar, B, Abu-Gharbieh, E, Abu-Rmeileh, NME, Aburuz, S, Abu-Zaid, A, Accrombessi, MMK, Adal, TG, Adamu, AA, Addo, IY, Addolorato, G, Adebiyi, AO, Adekanmbi, V, Adepoju, AV, Adetunji, CO, Adetunji, JB, Adeyeoluwa, TE, Adeyinka, DA, Adeyomoye, OI, Admass, BAA, Adnani, QES, Adra, S, Afolabi, AA, Afzal, MS, Afzal, S, Agampodi, SB, Agasthi, P, Aggarwal, M, Aghamiri, S, Agide, FD, Agodi, A, Agrawal, A, Agyemang-Duah, W, Ahinkorah, BO, Ahmad, A, Ahmad, D, Ahmad, F, Ahmad, MM, Ahmad, S, Ahmad, T, Ahmadi, K, Ahmadzade, AM, Ahmed, A, Ahmed, H, Ahmed, LA, Ahmed, MS, Ahmed, MB, Ahmed, SA, Ajami, M, Aji, B, Akara, EM, Akbarialiabad, H, Akinosoglou, K, Akinyemiju, T, Akkaif, MA, Akyirem, S, Al Hamad, H, Al Hasan, SM, Alahdab, F, Alalalmeh, SO, Alalwan, TA, Al-Aly, Z, Alam, K, Alam, M, Alam, N, Al-amer, RM, Alanezi, FM, Alanzi, TM, Al-Azzam, S, Albakri, A, Albashtawy, M, AlBataineh, MT, Alcalde-Rabanal, JE, Aldawsari, KA, Aldhaleei, WA, Aldridge, RW, Alema, HB, Alemayohu, MA, Alemi, S, Alemu, YM, Al-Gheethi, AAS, Alhabib, KF, Alhalaiqa, FAN, Al-Hanawi, MK, Ali, A, Ali, L, Ali, MU, Ali, R, Ali, S, Ali, SSS, Alicandro, G, Alif, SM, Alikhani, R, Alimohamadi, Y, Aliyi, AA, Aljasir, MAM, Aljunid, SM, Alla, F, Allebeck, P, Al-Marwani, S, Al-Maweri, SAA, Almazan, JU, Al-Mekhlafi, HM, Almidani, L, Almidani, O, Alomari, MA, Al-Omari, B, Alonso, J, Alqahtani, JS, Alqalyoobi, S, Alqutaibi, AY, Al-Sabah, SK, Altaany, Z, Altaf, A, Al-Tawfiq, JA, Altirkawi, KA, Aluh, DO, Alvis-Guzman, N, Alwafi, H, Al-Worafi, YM, Aly, H, Aly, S, Alzoubi, KH, Amani, R, Amare, AT, Amegbor, PM, Ameyaw, EK, Amin, TT, Amindarolzarbi, A, Amiri, S, Amirzade-Iranaq, MH, Amu, H, Amugsi, DA, Amusa, GA, Ancuceanu, R, Anderlini, D, Anderson, DB, Andrade, PP, Andrei, CL, Andrei, T, Angus, C, Anil, A, Anil, S, Anoushiravani, A, Ansari, H, Ansariadi, A, Ansari-Moghaddam, A, Antony, CM, Antriyandarti, E, Anvari, D, Anvari, S, Anwar, S, Anwar, SL, Anwer, R, Anyasodor, AE, Aqeel, M, Arab, JP, Arabloo, J, Arafat, M, Aravkin, AY, Areda, D, Aremu, A, Aremu, O, Ariffin, H, Arkew, M, Armocida, B, Arndt, MB, Ärnlöv, J, Arooj, M, Artamonov, AA, Arulappan, J, Aruleba, RT, Arumugam, A, Asaad, M, Asadi-Lari, M, Asgedom, AA, Asghariahmadabad, M, Asghari-Jafarabadi, M, Ashraf, M, Aslani, A, Astell-Burt, T, Athar, M, Athari, SS, Atinafu, BTT, Atlaw, HW, Atorkey, P, Atout, MMW, Atreya, A, Aujayeb, A, Ausloos, M, Avan, A, Awedew, AF, Aweke, AM, Ayala Quintanilla, BP, Ayatollahi, H, Ayuso-Mateos, JL, Ayyoubzadeh, SM, Azadnajafabad, S, Azevedo, RMS, Azzam, AY, B, DB, Babu, AS, Badar, M, Badiye, AD, Baghdadi, S, Bagheri, N, Bagherieh, S, Bah, S, Bahadorikhalili, S, Bahmanziari, N, Bai, R, Baig, AA, Baker, JL, Bako, AT, Bakshi, RK, Balakrishnan, S, Balasubramanian, M, Baltatu, OC, Bam, K, Banach, M, Bandyopadhyay, S, Banik, PC, Bansal, H, Bansal, K, Barbic, F, Barchitta, M, Bardhan, M, Bardideh, E, Barker-Collo, SL, Bärnighausen, TW, Barone-Adesi, F, Barqawi, HJ, Barrero, LH, Barrow, A, Barteit, S, Barua, L, Basharat, Z, Bashiri, A, Basiru, A, Baskaran, P, Basnyat, B, Bassat, Q, Basso, JD, Basting, AVL, Basu, S, Batra, K, Baune, BT, Bayati, M, Bayileyegn, NS, Beaney, T, Bedi, N, Beghi, M, Behboudi, E, Behera, P, Behnoush, AH, Behzadifar, M, Beiranvand, M, Bejarano Ramirez, DF, Béjot, Y, Belay, SA, Belete, CM, Bell, ML, Bello, MB, Bello, OO, Belo, L, Beloukas, A, Bender, RG, Bensenor, IM, Beran, A, Berezvai, Z, Berhie, AY, Berice, BN, Bernstein, RS, Bertolacci, GJ, Bettencourt, PJG, Beyene, KA, Bhagat, DS, Bhagavathula, AS, Bhala, N, Bhalla, A, Bhandari, D, Bhangdia, K, Bhardwaj, N, Bhardwaj, P, Bhardwaj, PV, Bhargava, A, Bhaskar, S, Bhat, V, Bhatti, GK, Bhatti, JS, Bhatti, MS, Bhatti, R, Bhutta, ZA, Bikbov, B, Bishai, JD, Bisignano, C, Bisulli, F, Biswas, A, Biswas, B, Bitaraf, S, Bitew, BD, Bitra, VR, Bjørge, T, Boachie, MK, Boampong, MS, Bobirca, AV, Bodolica, V, Bodunrin, AO, Bogale, EK, Bogale, KA, Bohlouli, S, Bolarinwa, OA, Boloor, A, Bonakdar Hashemi, M, Bonny, A, Bora, K, Bora Basara, B, Borhany, H, Borzutzky, A, Bouaoud, S, Boustany, A, Boxe, C, Boyko, EJ, Brady, OJ, Braithwaite, D, Brant, LC, Brauer, M, Brazinova, A, Brazo-Sayavera, J, Breitborde, NJK, Breitner, S, Brenner, H, Briko, AN, Briko, NI, Britton, G, Brown, J, Brugha, T, Bulamu, NB, Bulto, LN, Buonsenso, D, Burns, RA, Busse, R, Bustanji, Y, Butt, NS, Butt, ZA, Caetano dos Santos, FL, Calina, D, Cámera, LA, Campos, LA, Campos-Nonato, IR, Cao, C, Cao, Y, Capodici, A, Cárdenas, R, Carr, S, Carreras, G, Carrero, JJ, Carugno, A, Carvalheiro, CG, Carvalho, F, Carvalho, M, Castaldelli-Maia, JM, Castañeda-Orjuela, CA, Castelpietra, G, Catalá-López, F, Catapano, AL, Cattaruzza, MS, Cederroth, CR, Cegolon, L, Cembranel, F, Cenderadewi, M, Cercy, KM, Cerin, E, Cevik, M, Chadwick, J, Chahine, Y, Chakraborty, C, Chakraborty, PA, Chan, JSK, Chan, RNC, Chandika, RM, Chandrasekar, EK, Chang, C-K, Chang, J-C, Chanie, GS, Charalampous, P, Chattu, VK, Chaturvedi, P, Chatzimavridou-Grigoriadou, V, Chaurasia, A, Chen, AW, Chen, A-T, Chen, CS, Chen, H, Chen, MX, Chen, S, Cheng, C-Y, Cheng, ETW, Cherbuin, N, Cheru, WA, Chien, J-H, Chimed-Ochir, O, Chimoriya, R, Ching, PR, Chirinos-Caceres, JL, Chitheer, A, Cho, WCS, Chong, B, Chopra, H, Choudhari, SG, Chowdhury, R, Christopher, DJ, Chukwu, IS, Chung, E, Chung, S-C, Chutiyami, M, Cindi, Z, Cioffi, I, Claassens, MM, Claro, RM, Coberly, K, Cogen, RM, Columbus, A, Comfort, H, Conde, J, Cortese, S, Cortesi, PA, Costa, VM, Costanzo, S, Cousin, E, Couto, RAS, Cowden, RG, Cramer, KM, Criqui, MH, Cruz-Martins, N, Cuadra-Hernández, SM, Culbreth, GT, Cullen, P, Cunningham, M, Curado, MP, Dadana, S, Dadras, O, Dai, S, Dai, X, Dai, Z, Dalli, LL, Damiani, G, Darega Gela, J, Das, JK, Das, S, Dascalu, AM, Dash, NR, Dashti, M, Dastiridou, A, Davey, G, Dávila-Cervantes, CA, Davis Weaver, N, Davletov, K, De Leo, D, de Luca, K, Debele, AT, Debopadhaya, S, Degenhardt, L, Dehghan, A, Deitesfeld, L, Del Bo', C, Delgado-Enciso, I, Demessa, BH, Demetriades, AK, Deng, K, Deng, X, Denova-Gutiérrez, E, Deravi, N, Dereje, N, Dervenis, N, Dervišević, E, Des Jarlais, DC, Desai, HD, Desai, R, Devanbu, VGC, Dewan, SMR, Dhali, A, Dhama, K, Dhimal, M, Dhingra, S, Dhulipala, VR, Dias da Silva, D, Diaz, D, Diaz, MJ, Dima, A, Ding, DD, Ding, H, Dinis-Oliveira, RJ, Dirac, MA, Djalalinia, S, Do, THP, do Prado, CB, Doaei, S, Dodangeh, M, Dohare, S, Dokova, KG, Dolecek, C, Dominguez, R-MV, Dong, W, Dongarwar, D, D'Oria, M, Dorostkar, F, Dorsey, ER, dos Santos, WM, Doshi, R, Doshmangir, L, Dowou, RK, Driscoll, TR, Dsouza, HL, Dsouza, V, Du, M, Dube, J, Duncan, BB, Duraes, AR, Duraisamy, S, Durojaiye, OC, Dwyer-Lindgren, L, Dzianach, PA, Dziedzic, AM, E'mar, AR, Eboreime, E, Ebrahimi, A, Echieh, CP, Edinur, HA, Edvardsson, D, Edvardsson, K, Efendi, D, Efendi, F, Effendi, DE, Eikemo, TA, Eini, E, Ekholuenetale, M, Ekundayo, TC, El Sayed, I, Elbarazi, I, Elema, TB, Elemam, NM, Elgar, FJ, Elgendy, IY, ElGohary, GMT, Elhabashy, HR, Elhadi, M, El-Huneidi, W, Elilo, LT, Elmeligy, OAA, Elmonem, MA, Elshaer, M, Elsohaby, I, Emeto, TI, Engelbert Bain, L, Erkhembayar, R, Esezobor, CI, Eshrati, B, Eskandarieh, S, Espinosa-Montero, J, Esubalew, H, Etaee, F, Fabin, N, Fadaka, AO, Fagbamigbe, AF, Fahim, A, Fahimi, S, Fakhri-Demeshghieh, A, Falzone, L, Fareed, M, Farinha, CSES, Faris, MEM, Faris, PS, Faro, A, Fasanmi, AO, Fatehizadeh, A, Fattahi, H, Fauk, NK, Fazeli, P, Feigin, VL, Feizkhah, A, Fekadu, G, Feng, X, Fereshtehnejad, S-M, Feroze, AH, Ferrante, D, Ferrari, AJ, Ferreira, N, Fetensa, G, Feyisa, BR, Filip, I, Fischer, F, Flavel, J, Flood, D, Florin, BT, Foigt, NA, Folayan, MO, Fomenkov, AA, Foroutan, B, Foroutan, M, Forthun, I, Fortuna, D, Foschi, M, Fowobaje, KR, Francis, KL, Franklin, RC, Freitas, A, Friedman, J, Friedman, SD, Fukumoto, T, Fuller, JE, Fux, B, Gaal, PA, Gadanya, MA, Gaidhane, AM, Gaihre, S, Gakidou, E, Galali, Y, Galles, NC, Gallus, S, Ganbat, M, Gandhi, AP, Ganesan, B, Ganiyani, MA, Garcia-Gordillo, MA, Gardner, WM, Garg, J, Garg, N, Gautam, RK, Gbadamosi, SO, Gebi, TG, Gebregergis, MW, Gebrehiwot, M, Gebremeskel, TG, Georgescu, SR, Getachew, T, Gething, PW, Getie, M, Ghadiri, K, Ghahramani, S, Ghailan, KY, Ghasemi, M-R, Ghasempour Dabaghi, G, Ghasemzadeh, A, Ghashghaee, A, Ghassemi, F, Ghazy, RM, Ghimire, A, Ghoba, S, Gholamalizadeh, M, Gholamian, A, Gholamrezanezhad, A, Gholizadeh, N, Ghorbani, M, Ghorbani Vajargah, P, Ghoshal, AG, Gill, PS, Gill, TK, Gillum, RF, Ginindza, TG, Girmay, A, Glasbey, JC, Gnedovskaya, EV, Göbölös, L, Godinho, MA, Goel, A, Golchin, A, Goldust, M, Golechha, M, Goleij, P, Gomes, NGM, Gona, PN, Gopalani, SV, Gorini, G, Goudarzi, H, Goulart, AC, Goulart, BNG, Goyal, A, Grada, A, Graham, SM, Grivna, M, Grosso, G, Guan, S-Y, Guarducci, G, Gubari, MIM, Gudeta, MD, Guha, A, Guicciardi, S, Guimarães, RA, Gulati, S, Gunawardane, DA, Gunturu, S, Guo, C, Gupta, AK, Gupta, B, Gupta, MK, Gupta, M, Gupta, RD, Gupta, R, Gupta, S, Gupta, VB, Gupta, VK, Gurmessa, L, Gutiérrez, RA, Habibzadeh, F, Habibzadeh, P, Haddadi, R, Hadei, M, Hadi, NR, Haep, N, Hafezi-Nejad, N, Hailu, A, Haj-Mirzaian, A, Halboub, ES, Hall, BJ, Haller, S, Halwani, R, Hamadeh, RR, Hameed, S, Hamidi, S, Hamilton, EB, Han, C, Han, Q, Hanif, A, Hanifi, N, Hankey, GJ, Hanna, F, Hannan, MA, Haque, MN, Harapan, H, Hargono, A, Haro, JM, Hasaballah, AI, Hasan, I, Hasan, MT, Hasani, H, Hasanian, M, Hashi, A, Hasnain, MS, Hassan, I, Hassanipour, S, Hassankhani, H, Haubold, J, Havmoeller, RJ, Hay, SI, He, J, Hebert, JJ, Hegazi, OE, Heidari, G, Heidari, M, Heidari-Foroozan, M, Helfer, B, Hendrie, D, Herrera-Serna, BY, Herteliu, C, Hesami, H, Hezam, K, Hill, CL, Hiraike, Y, Holla, R, Horita, N, Hossain, MM, Hossain, S, Hosseini, M-S, Hosseinzadeh, H, Hosseinzadeh, M, Hosseinzadeh Adli, A, Hostiuc, M, Hostiuc, S, Hsairi, M, Hsieh, VC-R, Hsu, RL, Hu, C, Huang, J, Hultström, M, Humayun, A, Hundie, TG, Hussain, J, Hussain, MA, Hussein, NR, Hussien, FM, Huynh, H-H, Hwang, B-F, Ibitoye, SE, Ibrahim, KS, Iftikhar, PM, Ijo, D, Ikiroma, AI, Ikuta, KS, Ikwegbue, PC, Ilesanmi, OS, Ilic, IM, Ilic, MD, Imam, MT, Immurana, M, Inamdar, S, Indriasih, E, Iqhrammullah, M, Iradukunda, A, Iregbu, KC, Islam, MR, Islam, SMS, Islami, F, Ismail, F, Ismail, NE, Iso, H, Isola, G, Iwagami, M, Iwu, CCD, Iyamu, IO, Iyer, M, J, LM, Jaafari, J, Jacob, L, Jacobsen, KH, Jadidi-Niaragh, F, Jafarinia, M, Jafarzadeh, A, Jaggi, K, Jahankhani, K, Jahanmehr, N, Jahrami, H, Jain, N, Jairoun, AA, Jaiswal, A, Jamshidi, E, Janko, MM, Jatau, AI, Javadov, S, Javaheri, T, Jayapal, SK, Jayaram, S, Jebai, R, Jee, SH, Jeganathan, J, Jha, AK, Jha, RP, Jiang, H, Jin, Y, Johnson, O, Jokar, M, Jonas, JB, Joo, T, Joseph, A, Joseph, N, Joshua, CE, Joshy, G, Jozwiak, JJ, Jürisson, M, K, V, Kaambwa, B, Kabir, A, Kabir, Z, Kadashetti, V, Kadir, DH, Kalani, R, Kalankesh, LR, Kaliyadan, F, Kalra, S, Kamal, VK, Kamarajah, SK, Kamath, R, Kamiab, Z, Kamyari, N, Kanagasabai, T, Kanchan, T, Kandel, H, Kanmanthareddy, AR, Kanmiki, EW, Kanmodi, KK, Kannan S, S, Kansal, SK, Kantar, RS, Kapoor, N, Karajizadeh, M, Karanth, SD, Karasneh, RA, Karaye, IM, Karch, A, Karim, A, Karimi, SE, Karimi Behnagh, A, Kashoo, FZ, Kasnazani, QHA, Kasraei, H, Kassebaum, NJ, Kassel, MB, Kauppila, JH, Kaur, N, Kawakami, N, Kayode, GA, Kazemi, F, Kazemian, S, Kazmi, TH, Kebebew, GM, Kebede, AD, Kebede, F, Keflie, TS, Keiyoro, PN, Keller, C, Kelly, JT, Kempen, JH, Kerr, JA, Kesse-Guyot, E, Khajuria, H, Khalaji, A, Khalid, N, Khalil, AA, Khalilian, A, Khamesipour, F, Khan, A, Khan, G, Khan, I, Khan, IA, Khan, MN, Khan, M, Khan, MJ, Khan, MAB, Khan, ZA, Khan suheb, MZ, Khanmohammadi, S, Khatab, K, Khatami, F, Khatatbeh, H, Khatatbeh, MM, Khavandegar, A, Khayat Kashani, HR, Khidri, FF, Khodadoust, E, Khorgamphar, M, Khormali, M, Khorrami, Z, Khosravi, A, Khosravi, MA, Kifle, ZD, Kim, G, Kim, J, Kim, K, Kim, MS, Kim, YJ, Kimokoti, RW, Kinzel, KE, Kisa, A, Kisa, S, Klu, D, Knudsen, AKS, Kocarnik, JM, Kochhar, S, Kocsis, T, Koh, DSQ, Kolahi, A-A, Kolves, K, Kompani, F, Koren, G, Kosen, S, Kostev, K, Koul, PA, Koulmane Laxminarayana, SL, Krishan, K, Krishna, H, Krishna, V, Krishnamoorthy, V, Krishnamoorthy, Y, Krohn, KJ, Kuate Defo, B, Kucuk Bicer, B, Kuddus, MA, Kuddus, M, Kuitunen, I, Kulimbet, M, Kulkarni, V, Kumar, A, Kumar, H, Kumar, M, Kumar, R, Kumari, M, Kumie, FT, Kundu, S, Kurmi, OP, Kusnali, A, Kusuma, D, Kwarteng, A, Kyriopoulos, I, Kyu, HH, La Vecchia, C, Lacey, B, Ladan, MA, Laflamme, L, Lagat, AK, Lager, ACJ, Lahmar, A, Lai, DTC, Lal, DK, Lalloo, R, Lallukka, T, Lam, H, Lám, J, Landrum, KR, Lanfranchi, F, Lang, JJ, Langguth, B, Lansingh, VC, Laplante-Lévesque, A, Larijani, B, Larsson, AO, Lasrado, S, Lassi, ZS, Latief, K, Latifinaibin, K, Lauriola, P, Le, NHH, Le, TTT, Le, TDT, Ledda, C, Ledesma, JR, Lee, M, Lee, PH, Lee, SW, Lee, SWH, Lee, W-C, Lee, YH, LeGrand, KE, Leigh, J, Leong, E, Lerango, TL, Li, M-C, Li, W, Li, X, Li, Y, Li, Z, Ligade, VS, Likaka, ATM, Lim, L-L, Lim, SS, Lindstrom, M, Linehan, C, Liu, C, Liu, G, Liu, J, Liu, R, Liu, S, Liu, X, Llanaj, E, Loftus, MJ, López-Bueno, R, Lopukhov, PD, Loreche, AM, Lorkowski, S, Lotufo, PA, Lozano, R, Lubinda, J, Lucchetti, G, Lugo, A, Lunevicius, R, Ma, ZF, Maass, KL, Machairas, N, Machoy, M, Madadizadeh, F, Madsen, C, Madureira-Carvalho, ÁM, Maghazachi, AA, Maharaj, SB, Mahjoub, S, Mahmoud, MA, Mahmoudi, A, Mahmoudi, E, Mahmoudi, R, Majeed, A, Makhdoom, IF, Malakan Rad, E, Maled, V, Malekzadeh, R, Malhotra, AK, Malhotra, K, Malik, AA, Malik, I, Malta, DC, Mamun, AA, Mansouri, P, Mansournia, MA, Mantovani, LG, Maqsood, S, Marasini, BP, Marateb, HR, Maravilla, JC, Marconi, AM, Mardi, P, Marino, M, Marjani, A, Martinez, G, Martinez-Guerra, BA, Martinez-Piedra, R, Martini, D, Martini, S, Martins-Melo, FR, Martorell, M, Marx, W, Maryam, S, Marzo, RR, Masaka, A, Masrie, A, Mathieson, S, Mathioudakis, AG, Mathur, MR, Mattumpuram, J, Matzopoulos, R, Maude, RJ, Maugeri, A, Maulik, PK, Mayeli, M, Mazaheri, M, Mazidi, M, McGrath, JJ, McKee, M, McKowen, ALW, McLaughlin, SA, McPhail, SM, Mechili, EA, Medina, JRC, Mediratta, RP, Meena, JK, Mehra, R, Mehrabani-Zeinabad, K, Mehrabi Nasab, E, Mekene Meto, T, Meles, GG, Mendez-Lopez, MAM, Mendoza, W, Menezes, RG, Mengist, B, Mentis, A-FA, Meo, SA, Meresa, HA, Meretoja, A, Meretoja, TJ, Mersha, AM, Mesfin, BA, Mestrovic, T, Mettananda, KCD, Mettananda, S, Meylakhs, P, Mhlanga, A, Mhlanga, L, Mi, T, Miazgowski, T, Micha, G, Michalek, IM, Miller, TR, Mills, EJ, Minh, LHN, Mini, GK, Mir Mohammad Sadeghi, P, Mirica, A, Mirijello, A, Mirrakhimov, EM, Mirutse, MK, Mirzaei, M, Misganaw, A, Mishra, A, Misra, S, Mitchell, PB, Mithra, P, Mittal, C, Mobayen, M, Moberg, ME, Mohamadkhani, A, Mohamed, J, Mohamed, MFH, Mohamed, NS, Mohammad-Alizadeh-Charandabi, S, Mohammadi, S, Mohammadian-Hafshejani, A, Mohammadifard, N, Mohammed, H, Mohammed, M, Mohammed, S, Mohan, V, Mojiri-Forushani, H, Mokari, A, Mokdad, AH, Molinaro, S, Molokhia, M, Momtazmanesh, S, Monasta, L, Mondello, S, Moni, MA, Moodi Ghalibaf, A, Moradi, M, Moradi, Y, Moradi-Lakeh, M, Moradzadeh, M, Moraga, P, Morawska, L, Moreira, RS, Morovatdar, N, Morrison, SD, Morze, J, Mosser, JF, Motappa, R, Mougin, V, Mouodi, S, Mousavi, P, Mousavi, SE, Mousavi Khaneghah, A, Mpolya, EA, Mrejen, M, Mubarik, S, Muccioli, L, Mueller, UO, Mughal, F, Mukherjee, S, Mulita, F, Munjal, K, Murillo-Zamora, E, Musaigwa, F, Musallam, KM, Mustafa, A, Mustafa, G, Muthupandian, S, Muthusamy, R, Muzaffar, M, Myung, W, Nagarajan, AJ, Nagel, G, Naghavi, P, Naheed, A, Naik, 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Zhu, L, Ziafati, M, Zielińska, M, Zitoun, OA, Zoladl, M, Zou, Z, Zuhlke, LJ, Zumla, A, Zweck, E, Zyoud, SH, Wool, EE, and Murray, CJL
Published: 2024

2. Burden of disease scenarios for 204 countries and territories, 2022–2050: a forecasting analysis for the Global Burden of Disease Study 2021

Author: Vollset, SE, Ababneh, HS, Abate, YH, Abbafati, C, Abbasgholizadeh, R, Abbasian, M, Abbastabar, H, Abd Al Magied, AHA, Abd ElHafeez, S, Abdelkader, A, Abdelmasseh, M, Abd-Elsalam, S, Abdi, P, Abdollahi, M, Abdoun, M, Abdullahi, A, Abebe, M, Abiodun, O, Aboagye, RG, Abolhassani, H, Abouzid, M, Aboye, GB, Abreu, LG, Absalan, A, Abualruz, H, Abubakar, B, Abukhadijah, HJJ, Addolorato, G, Adekanmbi, V, Adetunji, CO, Adetunji, JB, Adeyeoluwa, TE, Adha, R, Adhikary, RK, Adnani, QES, Adzigbli, LA, Afrashteh, F, Afzal, MS, Afzal, S, Agbozo, F, Agodi, A, Agrawal, A, Agyemang-Duah, W, Ahinkorah, BO, Ahlstrom, AJ, Ahmad, A, Ahmad, F, Ahmad, MM, Ahmad, S, Ahmed, A, Ahmed, H, Ahmed, S, Ahmed, SA, Akinosoglou, K, Akkaif, MA, Akrami, AE, Akter, E, Al Awaidy, S, Al Hasan, SM, Al Mosa, AS, Al Ta'ani, O, Al Zaabi, OAM, Alahdab, F, Alajlani, MM, Al-Ajlouni, Y, Alalalmeh, SO, Al-Aly, Z, Alam, K, Alam, N, Alam, T, Alam, Z, Al-amer, RM, Alanezi, FM, Alanzi, TM, Albakri, A, Aldhaleei, WA, Aldridge, RW, Alemohammad, SY, Alemu, YM, Al-Gheethi, AAS, Al-Hanawi, MK, Ali, A, Ali, I, Ali, MU, Ali, R, Ali, SSS, Ali, VE, Ali, W, Al-Ibraheem, A, Alicandro, G, Alif, SM, Aljunid, SM, Alla, F, Almazan, JU, Al-Mekhlafi, HM, Alqutaibi, AY, Alrawashdeh, A, Alrousan, SM, Al-Sabah, SK, Alsabri, MA, Altaany, Z, Al-Tammemi, AB, Al-Tawfiq, JA, Altirkawi, KA, Aluh, DO, Alvis-Guzman, N, Al-Wardat, MS, Al-Worafi, YM, Aly, H, Alyahya, MS, Alzoubi, KH, Al-Zyoud, W, Amani, R, Ameyaw, EK, Amin, TT, Amindarolzarbi, A, Amiri, S, Amirzade-Iranaq, MH, Amu, H, Amugsi, DA, Ancuceanu, R, Anderlini, D, Anderson, DB, Andrade, PP, Andrei, CL, Andrei, T, Andrews, EA, Anil, A, Anil, S, Anoushiravani, A, Antony, CM, Antriyandarti, E, Anuoluwa, BS, Anvari, S, Anyasodor, AE, Appiah, F, Aquilano, M, Arab, JP, Arabloo, J, Arafa, EA, Arafat, M, Aravkin, AY, Ardekani, A, Areda, D, Aregawi, BB, Aremu, A, Ariffin, H, Arkew, M, Armani, K, Artamonov, AA, Arumugam, A, Asghari-Jafarabadi, M, Ashbaugh, C, Astell-Burt, T, Athari, SS, Atorkey, P, Atout, MMW, Aujayeb, A, Ausloos, M, Awad, H, Awotidebe, AW, Ayatollahi, H, Ayuso-Mateos, JL, Azadnajafabad, S, Azeez, FK, Azevedo, RMS, Badar, M, Baghdadi, S, Bagheri, M, Bagheri, N, Bai, R, Baker, JL, Bako, AT, Balakrishnan, S, Balcha, WF, Baltatu, OC, Barchitta, M, Bardideh, E, Barker-Collo, SL, Bärnighausen, TW, Barqawi, HJ, Barteit, S, Basiru, A, Basso, JD, Bastan, M-M, Basu, S, Bauckneht, M, Baune, BT, Bayati, M, Bayileyegn, NS, Behnoush, AH, Behzadi, P, Beiranvand, M, Bello, OO, Belo, L, Beloukas, A, Bemanalizadeh, M, Bensenor, IM, Benzian, H, Beran, A, Berezvai, Z, Bernstein, RS, Bettencourt, PJG, Beyene, KA, Beyene, MG, Bhagat, DS, Bhagavathula, AS, Bhala, N, Bhandari, D, Bharadwaj, R, Bhardwaj, N, Bhardwaj, P, Bhargava, A, Bhaskar, S, Bhat, V, Bhattacharjee, NV, Bhatti, GK, Bhatti, JS, Bhatti, MS, Bhuiyan, MA, Bisignano, C, Biswas, B, Bjørge, T, Bodolica, V, Bodunrin, AO, Bonakdar Hashemi, M, Bora Basara, B, Borhany, H, Bosoka, SA, Botero Carvajal, A, Bouaoud, S, 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Silva, AG, Dadras, O, Dai, X, Dai, Z, Dalton, BE, Damiani, G, Dandona, L, Dandona, R, Das, JK, Das, S, Dash, NR, Davletov, K, De la Hoz, FP, De Leo, D, Debopadhaya, S, Delgado-Enciso, I, Denova-Gutiérrez, E, Dervenis, N, Desai, HD, Devanbu, VGC, Dewan, SMR, Dhama, K, Dhane, AS, Dhingra, S, Dias da Silva, D, Diaz, D, Diaz, LA, Diaz, MJ, Dima, A, Ding, DD, Do, THP, do Prado, CB, Dodangeh, M, Doegah, PT, Dohare, S, Dong, W, D'Oria, M, Doshi, R, Dowou, RK, Dsouza, HL, Dsouza, V, Dube, J, Dumith, SC, Duncan, BB, Duraes, AR, Duraisamy, S, Durojaiye, OC, Dushpanova, A, Dutta, S, Dzianach, PA, Dziedzic, AM, Eboreime, E, Ebrahimi, A, Ebrahimi Kalan, M, Edinur, HA, Efendi, F, Eikemo, TA, Eini, E, Ekundayo, TC, El Arab, RA, El Sayed, I, Elamin, O, Elemam, NM, ElGohary, GMT, Elhadi, M, Elmeligy, OAA, Elmoselhi, AB, Elshaer, M, Elsohaby, I, Eltahir, ME, Emeto, TI, Eshrati, B, Eslami, M, Esmaeili, Z, Fabin, N, Fagbamigbe, AF, Fagbule, OF, Falzone, L, Fareed, M, Farinha, CSES, Faris, MEM, Faro, A, Fasihi, K, Fatehizadeh, A, Fauk, NK, Fazylov, T, Feigin, VL, Fekadu, G, Feng, X, Fereshtehnejad, S-M, Ferrara, P, Ferreira, N, Firew, BS, Fischer, F, Fitriana, I, Flavel, J, Flor, LS, Folayan, MO, Foley, KM, Fonzo, M, Force, LM, Foschi, M, Freitas, A, Fridayani, NKY, Fukutaki, KG, Furtado, JM, Fux, B, Gaal, PA, Gadanya, MA, Gallus, S, Ganesan, B, Ganiyani, MA, Gautam, RK, Gebi, TG, Gebregergis, MW, Gebrehiwot, M, Getacher, L, Getahun, GKA, Gething, PW, Ghadimi, DJ, Ghadirian, F, Ghafarian, S, Ghailan, KY, Ghasemi, M, Ghasempour Dabaghi, G, Ghazy, RM, Ghoba, S, Gholami, E, Gholamrezanezhad, A, Gholizadeh, N, Ghorbani, M, Ghorbani Vajargah, P, Ghotbi, E, Gil, AU, Gill, TK, Girmay, A, Glasbey, JC, Glushkova, EV, Gnedovskaya, EV, Göbölös, L, Goldust, M, Goleij, P, Golinelli, D, Gopalani, SV, Goulart, AC, Gouravani, M, Goyal, A, Grivna, M, Grosso, G, Guarducci, G, Gubari, MIM, Guicciardi, S, Guimarães, RA, Gulati, S, Gulisashvili, D, Gunawardane, DA, Guo, C, Gupta, AK, Gupta, R, Gupta, S, Gupta, VK, Haakenstad, A, Hadi, NR, Haep, N, Hafiz, A, Haghmorad, D, Haile, D, Hajj Ali, A, Haj-Mirzaian, A, Halboub, ES, Haller, S, Halwani, R, Hamagharib Abdullah, K, Hamdy, NM, Hamoudi, R, Hanifi, N, Hankey, GJ, Haq, ZA, Haque, MR, Harapan, H, Hargono, A, Haro, JM, Hasaballah, AI, Hasan, SMM, Hasanian, M, Hasnain, MS, Hassan, A, Haubold, J, Hay, SI, Hebert, JJ, Hegazi, OE, Heidari, M, Hemmati, M, Henson, CA, Herrera-Serna, BY, Herteliu, C, Heydari, M, Hezam, K, Hidayana, I, Hiraike, Y, Hoan, NQ, Holla, R, Hoogar, P, Horita, N, Hossain, MM, Hosseinzadeh, H, Hosseinzadeh, M, Hostiuc, M, Hostiuc, S, Hu, C, Huang, J, Hultström, M, Hundie, TG, Hunt, AJ, Hushmandi, K, Hussain, J, Hussain, MA, Hussein, NR, Huynh, H-H, Hwang, B-F, Ibitoye, SE, Iftikhar, PM, Ikiroma, AI, Ikwegbue, PC, Ilic, IM, Ilic, MD, Immurana, M, Isa, MA, Islam, MR, Islam, SMS, Ismail, F, Ismail, NE, Isola, G, Iwagami, M, Iyamu, IO, Jacob, L, Jacobsen, KH, Jafarinia, M, Jahankhani, K, Jahanmehr, N, Jain, N, Jairoun, AA, Jakhmola Mani, DR, Jamil, S, Jamora, RDG, Jatau, AI, Javadov, S, Javaheri, T, Jayaram, S, Jee, SH, Jeganathan, J, Jiang, H, Jokar, M, Jonas, JB, Joseph, N, Joshua, CE, Jürisson, M, K, V, Kabir, A, Kabir, Z, Kadashetti, V, Kalankesh, LR, Kalra, S, Kamath, A, Kamath, R, Kamireddy, A, Kanaan, M, Kanchan, T, Kanmiki, EW, Kanmodi, KK, Kansal, SK, Karim, A, Karkhah, S, Kashoo, FZ, Kasraei, H, Kassel, MB, Katikireddi, SV, Kauppila, JH, Kaur, H, Kayode, GA, Kazemi, F, Kazemian, S, Kebede, F, Kendal, ES, Kesse-Guyot, E, Khademvatan, S, Khajuria, H, Khalaji, A, Khalid, A, Khalid, N, Khalilian, A, Khamesipour, F, Khan, F, Khan, MJ, Khan, MAB, Khanmohammadi, S, Khatab, K, Khatatbeh, H, Khatatbeh, MM, Khatib, MN, Khayat Kashani, HR, Kheirallah, KA, Khokhar, M, Khormali, M, Khorrami, Z, Khosla, AA, Khosravi, M, Khosrowjerdi, M, Khubchandani, J, Kifle, ZD, Kim, G, Kim, JS, Kim, MS, Kim, YJ, Kimokoti, RW, Kisa, A, Kisa, S, Knibbs, LD, Knudsen, AKS, Kochhar, S, Kolahi, A-A, Kompani, F, Koren, G, 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Published: 2024

3. Global incidence, prevalence, years lived with disability (YLDs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries in 204 countries and territories and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021

Author: Ferrari, AJ, Santomauro, DF, Aali, A, Abate, YH, Abbafati, C, Abbastabar, H, Abd ElHafeez, S, Abdelmasseh, M, Abd-Elsalam, S, Abdollahi, A, Abdullahi, A, Abegaz, KH, Abeldaño Zuñiga, RA, Aboagye, RG, Abolhassani, H, Abreu, LG, Abualruz, H, Abu-Gharbieh, E, Abu-Rmeileh, NME, Ackerman, IN, Addo, IY, Addolorato, G, Adebiyi, AO, Adepoju, AV, Adewuyi, HO, Afyouni, S, Afzal, S, Agodi, A, Ahmad, A, Ahmad, D, Ahmad, F, Ahmad, S, Ahmed, A, Ahmed, LA, Ahmed, MB, Ajami, M, Akinosoglou, K, Akkaif, MA, Al Hasan, SM, Alalalmeh, SO, Al-Aly, Z, Albashtawy, M, Aldridge, RW, Alemu, MD, Alemu, YM, Alene, KA, Al-Gheethi, AAS, Alharrasi, M, Alhassan, RK, Ali, MU, Ali, R, Ali, SSS, Alif, SM, Aljunid, SM, Al-Marwani, S, Almazan, JU, Alomari, MA, Al-Omari, B, Altaany, Z, Alvis-Guzman, N, Alvis-Zakzuk, NJ, Alwafi, H, Al-Wardat, MS, Al-Worafi, YM, Aly, S, Alzoubi, KH, Amare, AT, Amegbor, PM, Ameyaw, EK, Amin, TT, Amindarolzarbi, A, Amiri, S, Amugsi, DA, Ancuceanu, R, Anderlini, D, Anderson, DB, Andrade, PP, Andrei, CL, Ansari, H, Antony, CM, Anwar, S, Anwar, SL, Anwer, R, Anyanwu, PE, Arab, JP, Arabloo, J, Arafat, M, Araki, DT, Aravkin, AY, Arkew, M, Armocida, B, Arndt, MB, Arooj, M, Artamonov, AA, Aruleba, RT, Arumugam, A, Ashbaugh, C, Ashemo, MY, Ashraf, M, Asika, MO, Askari, E, Astell-Burt, T, Athari, SS, Atorkey, P, Atout, MMW, Atreya, A, Aujayeb, A, Ausloos, M, Avan, A, Awotidebe, AW, Awuviry-Newton, K, Ayala Quintanilla, BP, Ayuso-Mateos, JL, Azadnajafabad, S, Azevedo, RMS, Babu, AS, Badar, M, Badiye, AD, Baghdadi, S, Bagheri, N, Bah, S, Bai, R, Baker, JL, Bakkannavar, SM, Bako, AT, Balakrishnan, S, Bam, K, Banik, PC, Barchitta, M, Bardhan, M, Bardideh, E, Barker-Collo, SL, Barqawi, HJ, Barrow, A, Barteit, S, Barua, L, Bashiri Aliabadi, S, Basiru, A, Basu, S, Bathini, PP, Batra, K, Baune, BT, Bayileyegn, NS, Behnam, B, Behnoush, AH, Beiranvand, M, Bejarano Ramirez, DF, Bell, ML, Bello, OO, Beloukas, A, Bensenor, IM, Berezvai, Z, Bernabe, E, Bernstein, RS, Bettencourt, 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Published: 2024

4. Personalized treatment options for thyroid cancer: current perspectives

Author: Khatami F, Larijani B, Nikfar S, Hasanzad M, Fendereski K, and Tavangar SM
Subjects: Personalized Medicine, Target therapy, Molecular testing, Therapeutics. Pharmacology, RM1-950
Abstract: Fatemeh Khatami,1 Bagher Larijani,2,3 Shekoufeh Nikfar,3,4 Mandana Hasanzad,3,5 Kiarad Fendereski,6 Seyed Mohammad Tavangar1,7 1Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran; 2Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran; 3Personalized Medicine Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran; 4Department of Pharmacoeconomics and Pharmaceutical Administration, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran; 5Medical Genomics Research Center, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran; 6Pediateric Urology and Regenerative Medicine Research Center, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran; 7Department of Pathology, Dr. Shariati Hospital, Tehran University of Medical Sciences, Tehran, IranCorrespondence: Seyed Mohammad TavangarDepartment of Pathology, Dr. Shariati Hospital, Tehran University of Medical Sciences, Jalale Ale Ahmad Ave, Tehran, IranTel +98 218 490 2187Fax +98 218 863 3078Email Tavangar@ams.ac.irAbstract: Thyroid cancer is one of the most common endocrine malignancies, with increasing incidence all over the world. In spite of good prognosis for differentiated thyroid carcinoma, for an unknown reason, about 5–10% of the patients, the cancer will show aggressive behavior, develop metastasis, and be refractory to treatment strategies like radioactive iodine. Regarding the genetic information, each thyroid cancer patient can be considered as an individual unique one, with unique genetic information. Contrary to standard chemotherapy drugs, target therapy components aim at one or more definite molecular pathway on cancer cells, so their selection is underlying patient’s genetic information. Nowadays, several mutations and rearrangements including BRAF, VEGF receptors, RET, and RET/PTC, KDR, KIT, PDGFRA, CD274, and JAK2 are taken into account for the therapeutic components like larotrectinib (TRK inhibitor), vemurafenib, sunitinib, sorafenib, selumetinib, and axitinib. With the new concept of personalized treatment of thyroid cancer diagnoses, planning treatment, finding out how well treatment will work, and estimating a prognosis has changed for the better over the last decade.Keywords: personalized medicine, target therapy, molecular testing
Published: 2019

5. Oncometabolites as biomarkers in thyroid cancer: a systematic review

Author: Khatami F, Payab M, Sarvari M, Gilany K, Larijani B, Arjmand B, and Tavangar SM
Subjects: Biomarkers, Oncometabolites, Thyroid Cancer (TC), Metabolite profile, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract: Fatemeh Khatami,1 Moloud Payab,2 Masoumeh Sarvari,3 Kambiz Gilany,3–5 Bagher Larijani,6 Babak Arjmand,7 Seyed Mohammad Tavangar1,8 1Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran; 2Obesity and Eating Habits Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran; 3Metabolomics and Genomics Research Center, Endocrinology and Metabolomics Molecular Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran; 4Reproductive Biotechnology Research Center, Avicenna Research Institute, Academic Center for Education, Culture and Research (ACECR), Tehran, Iran; 5Integrative Oncology Department, Breast Cancer Research Center, Motamed Cancer Institute, Acercr, Tehran, Iran; 6Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran; 7Cell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran; 8Department of Pathology, Dr. Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran Introduction: Thyroid cancer (TC) is an important common endocrine malignancy, and its incidence has increased in the past decades. The current TC diagnosis and classification tools are fine-needle aspiration (FNA) and histological examination following thyroidectomy. The metabolite profile alterations of thyroid cells (oncometabolites) can be considered for current TC diagnosis and management protocols.Methods: This systematic review focuses on metabolite alterations within the plasma, FNA specimens, and tissue of malignant TC contrary to benign, goiter, or healthy TC samples. A systematic search of MEDLINE (PubMed), Scopus, Embase, and Web of Science databases was conducted, and the final 31 studies investigating metabolite biomarkers of TC were included.Results: A total of 15 targeted studies and 16 untargeted studies revealed several potential metabolite signatures of TC such as glucose, fructose, galactose, mannose, 2-keto-d-gluconic acid and rhamnose, malonic acid and inosine, cholesterol and arachidonic acid, glycosylation (immunoglobulin G [IgG] Fc-glycosylation), outer mitochondrial membrane 20 (TOMM20), monocarboxylate transporter 4 (MCT4), choline, choline derivatives, myo-/scyllo-inositol, lactate, fatty acids, several amino acids, cell membrane phospholipids, estrogen metabolites such as 16 alpha-OH E1/2-OH E1 and catechol estrogens (2-OH E1), and purine and pyrimidine metabolites, which were suggested as the TC oncometabolite.Conclusion: Citrate was suggested as the first most significant biomarker and lactate as the second one. Further research is needed to confirm these biomarkers as the TC diagnostic oncometabolite. Keywords: biomarkers, oncometabolites, thyroid cancer, TC, systematic review
Published: 2019

6. Lung tissue engineering and preservation of alveolar microstructure using a novel casting method

Author: Kajbafzadeh, A-m, primary, Sabetkish, N, additional, Sabetkish, S, additional, Tavangar, Sm, additional, Beigi, Rs Hossein, additional, Talebi, Ma, additional, Akbarzadeh, A, additional, and Nikfarjam, L, additional
Published: 2014
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7. Relationship between genetic polymorphism of glutathione S-transferase-p1 and p53 protein accumulation in Iranian esophageal squamous cell carcinoma patients

Author: Allameh, A, primary, Biramijamal, F, additional, Mohammadzadeh, SH, additional, Rasmi, Y, additional, Tavangar, SM, additional, Jamali-Zavarei, M, additional, and Sharifi, R, additional
Published: 2008
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8. Lung tissue engineering and preservation of alveolar microstructure using a novel casting method.

Author: Kajbafzadeh, A-m, Sabetkish, N, Sabetkish, S, Tavangar, Sm, Beigi, Rs Hossein, Talebi, Ma, Akbarzadeh, A, and Nikfarjam, L
Subjects: TISSUE engineering, TISSUE preservation, LABORATORY rats, SCANNING electron microscopy, GREEN fluorescent protein, MICROSTRUCTURE
Abstract: We used a rat model to decellularize and seed alveolar cells on a three-dimensional lung scaffold to preserve alveolar microarchitecture. We verified the preservation of terminal respiratory structure by casting and by scanning electron microscopy (SEM) of the casts after decellularization. Whole lungs were obtained from 12 healthy Sprague-Dawley rats, cannulated through the trachea under sterile conditions, and decellularized using a detergent-based method. Casting of both natural and decellularized lungs was performed to verify preservation of the inner microstructure of scaffolds for further cell seeding. Alveolar cell seeding was performed using green fluorescent protein (GFP) lung cells and non-GFP lung cells, and a peristaltic pump. We assessed cell seeding using histological and immunohistochemical staining, and enzymatic evaluation. All cellular components were removed completely from the scaffolds, and histological staining and SEM of casts were used to verify the preservation of tissue structure. Tensile tests verified conservation of biomechanical properties. The hydroxyproline content of decellularized lungs was similar to native lung. Histological and immunohistochemical evaluations showed effective cell seeding on decellularized matrices. Enzymatic measurement of trypsin and alpha 1 antitrypsin suggested the potential functional properties of the regenerated lungs. Casts produced by our method have satisfactory geometrical properties for further cell seeding of lung scaffolds. Preservation of micro-architecture and terminal alveoli that was confirmed by SEM of lung casts increases the probability of an effective cell seeding process. [ABSTRACT FROM AUTHOR]
Published: 2015
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9. Endocrine cancer in Iran: Based on cancer registry system

Author: Larijani, Bagher, primary, Haghpanah, V, additional, Soliemanpour, B, additional, Heshmat, R, additional, Mosavi-Jarrahi, AR, additional, Tavangar, SM, additional, and Malekzadeh, R, additional
Published: 2006
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10. Gastrointestinal: Polypoid arteriovenous malformation of the colon

Author: NASSERI-MOGHADDAM, S, primary, MOHAMADNEJAD, M, additional, MALEKZADEH, R, additional, and TAVANGAR, SM, additional
Published: 2004
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11. Relationship between genetic polymorphism of glutathione S-transferase-p1 and p53 protein accumulation in Iranian esophageal squamous cell carcinoma patients.

Author: Sharifi R, Allameh A, Biramijamal F, Mohammadzadeh SH, Rasmi Y, Tavangar SM, Jamali-Zavarei M, Sharifi, R, Allameh, A, Biramijamal, F, Mohammadzadeh, S H, Rasmi, Y, Tavangar, S M, and Jamali-Zavarei, M
Abstract: Background: It has been reported that the activity of glutathione S-transferase (GST) is over-expressed in plasma and esophagus biopsies in Iranian patients suffering from esophageal squamous cell carcinoma (SCC). The aim of this study was to find out the frequency of GST-P genotypes in these patients. Moreover, the association of GST-P genotypes with p53 protein accumulation in esophageal epithelium was investigated.Materials and Methods: DNA isolated from paraffin-embedded tissue biopsies from patients suffering from esophageal SCC (n = 56) were collected. polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) using Alw261 enzyme was applied to determine GST-P genotypes (Ile 105 Val). All the samples were also subjected to immunohistochemistry (IHC) for p53.Results: The frequency of GST-P genotypes in Iranian esophagus SCC patients for Ile/Ile, Ile/Val and Val/Val was 73.2, 21.5 and 5.3%. There was no association between GST-P polymorphism and p53 accumulation in esophageal epithelial cells.Conclusions: The frequency of GST-P polymorphism was not associated with p53 protein accumulation in esophagus epithelium. The frequency of polymorphic variants of GST-P, Ile/Ile, Ile/Val and Val/Val in SCC patients may suggest that Ile to Val substitution in GST-P gene dose not represent susceptibility to SCC in high-risk Iranian population. [ABSTRACT FROM AUTHOR]
Published: 2008

12. Liver histology and HBV DNA levels in chronically HBV infected patients with persistently normal alanine aminotransferase.

Author: Montazeri G, Rahban M, Mohamadnejad M, Zamani F, Hooshyar A, Fazlolahi A, Abedian S, Ghoujeghi F, Estakhri A, Montazeri F, Razjoyan H, Mamarabadi M, Alimohamadi M, Tavangar SM, and Malekzadeh R
Abstract: BACKGROUND: Data on histological activity and HBV DNA levels in patients with chronic HBV infection and persistently normal alanine aminotransferase levels are sparse. We aimed to investigate the histological activity and HBV DNA levels in these patients. METHODS: There were 132 patients with HBeAg negative chronic HBV infection and persistently normal alanine aminotransferase levels that were included prospectively. Data were dichotomized according to the median levels. Associations of histology with HBV DNA and other variables were assessed. RESULTS: A total of 80 patients were male. The median age was 36 years. The median baseline HBV DNA was 2.9Log10 IU/mL. There were 50 cases (38%) with a total score > or = 5, 53 cases (40.2%) had grade > or = 4 and 40 cases (30.3%) had stage > or = 2. A baseline HBV DNA <2000 IU/mL was seen in 24 cases (48%) of those with total score > or = 5, 28 cases (53%) of those with grade > or = 4 and 9 cases (22.5%) with stage > or = 2. Multivariate analysis of baseline HBV DNA above the median level significantly predicted the total score, grade and stage with an adjusted odds ratio of 5.43, 3.47, and 4.23, respectively when compared to below median values. A second liver biopsy was performed in 61 patients. The median time interval between the two biopsies was 40 months. Total scores of 23 cases (38%) progressed by > or = 2 scores and the HBV DNA of 18 cases (22.5%) increased by > or = 1 Log10 IU when compared to baseline values. CONCLUSION: HBeAg negative chronic HBV infection with persistently normal alanine aminotransferase is not a silent disease. Active liver disease may be seen in such patients with viral loads less than 2000 IU/mL. [ABSTRACT FROM AUTHOR]
Published: 2010

13. A modification of the Brunt system for scoring liver histology of patients with non-alcoholic fatty liver disease.

Author: Merat S, Khadem-Sameni F, Nouraie M, Derakhshan MH, Tavangar SM, Mossaffa S, Malekzadeh R, and Sotoudeh M
Abstract: BACKGROUND: Nonalcoholic steatohepatitis is a common cause of chronic liver disease. It is important to have a uniform and validated method for scoring liver histology in these patients. Therefore, we propose a modification of the Brunt system by scoring the four histologic features separately and reporting their sums as the nonalcoholic steatohepatitis activity index. METHODS: A nonalcoholic steatohepatitis activity index was defined which scored the grade of disease activity between 0 and 12 according to four histologic features: steatosis, hepatocyte ballooning, portal inflammation, and lobular inflammation. Fibrosis was separately scored between 0 and 4. A total of 60 liver specimens collected from nonalcoholic steatohepatitis patients were scored by two pathologists at the time of biopsy and after three months. Liver enzyme levels were also correlated with the histologic score. RESULTS: The intra-rater agreement (weighted kappa) for various variables of the scoring system was between 0.59 and 0.80 for one pathologist and 0.78 to 0.95 for the other. The repeatability of the nonalcoholic steatohepatitis activity index was excellent with only 4% of the repeated measures out of the acceptable range of agreement. In addition, liver enzyme levels strongly correlated with the nonalcoholic steatohepatitis activity index. CONCLUSION: This system provides a fine graduation of liver histologic damage in nonalcoholic steatohepatitis and is well suited for use in clinical trials or natural history studies. [ABSTRACT FROM AUTHOR]
Published: 2010

14. Enhanced staging of extrahepatic hepatocellular carcinoma metastasis through dual-tracer PET/computed tomography: a systematic review and meta-analysis.

Author: Mohebbi A, Kiani I, Mohammadzadeh S, Mirza-Aghazadeh-Attari M, Mohammadi A, and Tavangar SM
Subjects: Humans, Neoplasm Staging, Fluorodeoxyglucose F18, Positron Emission Tomography Computed Tomography, Carcinoma, Hepatocellular diagnostic imaging, Carcinoma, Hepatocellular pathology, Liver Neoplasms diagnostic imaging, Liver Neoplasms secondary, Liver Neoplasms pathology, Neoplasm Metastasis
Abstract: The aim of this study was to quantify the diagnostic value of dual-tracer PET/computed tomography (CT) with 11 C-acetate and fluorodeoxyglucose (FDG) in per-lesion and per-patient and its effect on clinical decision-making for choosing the most appropriate management. The study protocol is registered a priori at https://osf.io/rvm75/ . PubMed, Web of Science, Embase , and Cochrane Library were searched for relevant studies until 1 June 2023. Studies regarding the review question were included. The Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2) was used to assess bias risk. Per-lesion and per-patient diagnostic performance were calculated for: (1) 11 C-acetate alone; (2) FDG alone; and (3) dual tracer of 11 C-acetate and FDG. A direct comparison of these three combinations was made. The possible sources of statistical heterogeneity were also examined. We also calculated the percentage change in clinical decision-making when dual-tracer PET/CT was added to conventional imaging routinely used for metastatic evaluation (CT/MRI). Grading of Recommendations, Assessment, Development, and Evaluations tool was used to evaluate the certainty of evidence. Eight studies including 521 patients and 672 metastatic lesions were included. Dual-tracer PET/CT had a per-lesion sensitivity of 96.3% [95% confidence interval (CI), 91.8-98.4%] and per-patient sensitivity of 95.5% (95% CI, 89.1-98.2%) which were highly superior to either of tracers alone. Per-patient specificity was 98.5% (84.1-99.9%) which was similar to either of tracers alone. Overall, 9.3% (95% CI, 4.7-13.9%) of the patients had their management beneficially altered by adding dual-tracer PET/CT to their conventional CT/MRI results. Dual-tracer PET/CT substantially outperforms single-tracer methods in detecting extrahepatic hepatocellular carcinoma metastases, evidencing its reliability and significant role in refining clinical management strategies based on robust diagnostic performance., (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.)
Published: 2024
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15. Diagnostic performance of ultrasound elastography in differentiating hepatocellular carcinoma and intrahepatic cholangiocarcinoma: a systematic review and meta-analysis.

Author: Mohebbi A, Mohammadzadeh S, Mohebbi S, Mohammadi A, and Tavangar SM
Abstract: Purpose: To evaluate the diagnostic value of ultrasound elastography (USE) for characterizing hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC)., Methods: The protocol was pre-registered a priori at ( https://osf.io/namvk/ ). Using PubMed, Web of Science, Embase, and Cochrane Library, we found studies up to April 20, 2024 by searching HCC, ICC, and USE as keywords. Parameters of USE were directly compared between HCC and ICC patients using random-effects bivariate model on STATA 17.0, MedCalc 20.0, and Psychometrica. Trim & fill method and sensitivity analysis were also performed., Results: Eighteen studies were included with 1057 patients, consisting of 863 HCC lesions, 188 ICC lesions, and 6 mixed lesions. The pooled E mean values of HCC and ICC were 28.3 (CI = 19.8 to 36.8) and 44.0 (CI = 20.9 to 67.2). HCC tumors were 34.3% softer than ICC while peritumoral tissue in HCC lesions was 75% stiffer than ICC lesions based on E mean . The strain value index (tumoral-to-peritumoral ratio) in HCC patients was 49.4% less than that of ICC patients. USE demonstrated a pool sensitivity of 87% (CI = 73-95%), specificity of 82% (CI = 65-92%), positive likelihood ratio of 4.8 (CI = 2.2 to 10.3), negative likelihood ratio of 0.16 (CI = 0.07 to 0.37), and diagnostic odds ratio of 31 (CI = 7 to 127) in differentiation of ICC from HCC., Conclusion: By evaluating tumoral and pre-tumoral stiffness, along with strain value index, USE may provide a valuable quantitative diagnostic tool for accurately differentiating HCC and ICC., (© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Published: 2024
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16. Qualitative and quantitative differentiation efficiency of dual-tracer PET/CT with 18F-fluorodeoxyglucose and 11 C-acetate for primary hepatocellular carcinoma: a systematic review and meta-analysis.

Author: Mohebbi A, Kiani I, Mohammadzadeh S, Mohammadi A, and Tavangar SM
Abstract: Purpose: Primary hepatocellular carcinoma (HCC) represents a substantial global health challenge. Early diagnosis of HCC is crucial for improved patient outcomes. The aim of this study was to assess qualitative and quantitative diagnostic performance of PET/CT using 11 C-acetate and [18F]-fluorodeoxyglucose (FDG) in detection of primary HCC and to determine if 11 C-acetate added to [18F]-FDG alleviates the low sensitivity rate mentioned in guidelines., Methods: Protocol was pre-registered at https://osf.io/2vcb9 . We searched PubMed, Web of Science, Embase, and the Cochrane Library for included studies. Quality Assessment of Diagnostic Accuracy Studies 2 was used to assess the risk of bias. Possible sources of statistical heterogeneity were explored. Additionally, mentioned three PET/CT tests were evaluated for their diagnostic performance in differentiating HCC from its differential diagnoses. Grades of Recommendation, Assessment, Development, and Evaluation was used to assess quality of generated evidence., Results: Twenty-four studies were analyzed. Qualitative dual-tracer PET/CT demonstrated 92.0% per-lesion sensitivity, and a significantly higher direct sensitivity difference of 30% to conventional CT, 44.7% to [18F]-FDG, and 12.0% to 11 C-acetate. Regarding differentiation rate, [18F]-FDG was superior to 11 C-acetate in poorly differentiated lesions while 11 C-acetate was superior in well-differentiated lesions. Regarding size, dual tracer combination solved the high missing rate of HCC lesions in 1-2 cm and 2-5 cm groups but could not help in size < 1 cm., Conclusion: Dual-tracer PET/CT utilizing 11 C-acetate and [18F]-FDG represents a sensitive method for detecting primary HCC. By concurrently quantifying or qualifying the uptake of 11 C-acetate and [18F]-FDG, this multimodal approach enables precise localization of intrahepatic lesions., (© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Published: 2024
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17. From balance to imbalance: disruption of plasma glutathione concentration in micropapillary thyroid carcinoma.

Author: Eskandari F, Hedayati M, Tavangar SM, Rezaei F, Khodagholipour A, and Razavi SA
Abstract: Background: Despite the presence of evidence that establishes a strong correlation between oxidative stress and thyroid cancer, there exists a scarcity of research that investigates the specific role of glutathione as an important antioxidant in this particular context. The objective of this study was to assess the altered balance of oxidative stress in cases of thyroid cancer, which includes both papillary thyroid carcinoma (PTC) and micro PTC (mPTC), by examining and comparing the total antioxidant capacity (TAC), total oxidant status (TOS), oxidative stress index (OSI), reduced glutathione (GSH), oxidized glutathione (GSSG), and GSSG/GSH ratio with those of individuals diagnosed with multinodular goiter (MNG) as well as Healthy subjects., Materials and Methods: Plasma samples were collected from 92 patients (23 mPTC, 23 PTC, 23 MNG, 23 Healthy). The levels of TAC, TOS, GSH, and GSSG were measured using a commercial assay kits, and the OSI and GSSG/GSH ratio were calculated for each sample. Statistical analyses were performed to compare the oxidative stress between the groups., Results: The plasma levels of TOS were significantly higher in the mPTC, PTC, and MNG groups compared to the Healthy individuals (p < 0.05). The OSI in the mPTC and PTC groups showed a significant increase compared to the Healthy group (p < 0.05). The levels of GSH in mPTC and PTC were markedly lower compared to the Healthy subjects (p < 0.01). Interestingly, the concentration of GSH in mPTC was found to be considerably lower than in PTC and MNG patients (p < 0.01)., Conclusion: These findings indicate that GSH may be a useful biomarker for evaluating oxidative stress and antioxidant system status in patients with PTC, especially mPTC. Low levels of GSH may indicate increased levels of oxidative stress, which may contribute to the development and progression of mPTC to PTC., (© 2024. The Author(s).)
Published: 2024
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18. Sumatriptan mitigates bleomycin-induced lung fibrosis in male rats: Involvement of inflammation, oxidative stress and α-SMA.

Author: Bahramifar A, Jafari RM, Sheibani M, Manavi MA, Rashidian A, Tavangar SM, Akbariani M, Mohammadi Hamaneh A, Goudarzi R, Shadboorestan A, and Dehpour AR
Subjects: Animals, Male, Rats, Lung pathology, Lung drug effects, Lung metabolism, Bleomycin toxicity, Oxidative Stress drug effects, Sumatriptan pharmacology, Rats, Wistar, Actins metabolism, Inflammation pathology, Inflammation drug therapy, Inflammation metabolism, Inflammation chemically induced, Pulmonary Fibrosis chemically induced, Pulmonary Fibrosis drug therapy, Pulmonary Fibrosis metabolism, Pulmonary Fibrosis pathology
Abstract: Introduction: Idiopathic pulmonary fibrosis (IPF) is a fibrotic lung condition that produces symptoms including coughing which may cause by excessive accumulation of scar tissue inflammatory and oxidative stress exacerbation. Sumatriptan, utilized for migraine treatment as a selective 5-HT 1B/1D receptor agonist, has demonstrated significant anti-inflammatory and antioxidant properties in multiple preclinical investigations. Operating primarily on serotonin receptors, sumatriptan leverages the diverse physiological functions of serotonin, playing a pivotal role in regulating both inflammation and oxidative stress which is particularly relevant in the context of IPF., Materials & Methods: Thirty-five male Wistar rats were divided to five group, including: Sham (without IPF induction), control (BLM 5 mg/kg, intraperitoneally), and three fibrosis group with sumatriptan (0.5, 1, and 3 mg/kg, i.p. for 2 weeks) administration. IPF was induced by injection of BLM (single dose, 5 mg/kg intratracheally). Lung tissues were separated for measurement of myeloperoxidase (MPO) as an oxidative stress hallmark, and tumor necrosis factor-α (TNF-α), interleukin-1β (IL-β), and transforming growth factor-β (TGF-β) as inflammatory markers as well as alpha smooth muscle actin (α-SMA). Also, for histological investigations, tissue damages were assessed by Hematoxylin-eosin (H&E) and Masson's trichrome staining method., Results: BLM-induced fibrosis could increase α-SMA, MPO, TNF-α, IL-1β, and TGF-β, while treatment with sumatriptan has reversed the α-SMA, MPO, and IL-1β levels. Moreover, the results of H&E and Masson's trichrome staining indicated that sumatriptan (1 and 3 mg/kg) reduced tissue damages, alveolar wall thickness, collagen accumulation, and pulmonary fibrosis induced by BLM., Conclusion: According to the data achieved from this study, Sumatriptan appears to have therapeutic benefits in IPF, possibly via reducing α-SMA as well as inflammation and the toxicity caused by oxidative stress., Competing Interests: Declaration of Competing Interest None, (Copyright © 2024 Elsevier Ltd. All rights reserved.)
Published: 2024
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19. Spermidine Exerts Protective Effects in Random-Pattern Skin Flap Survival in Rats: Possible Involvement of Inflammatory Cytokines, Nitric Oxide, and VEGF.

Author: Jouyban K, Mohammad Jafari R, Charkhpour M, Rezaei H, Seyfinejad B, Manavi MA, Tavangar SM, and Dehpour AR
Abstract: Background: Distal necrosis and inflammation are two of the most common health consequences of random-pattern skin flaps survival (SFS). Anti-inflammatory effects of spermidine have been identified in various studies. On the other hand, considering the involvement of the nitric oxide molecule in the spermidine mode of action and also its role in skin tissue function, we analyzed the possible effects of spermidine on the SFS and also, potential involvement of nitrergic pathway and inflammatory cytokine in these phenomena., Methods: Each rat was pretreated with either a vehicle (control) or various doses of spermidine (0.5, 1, 3, 5, 10 and 30 mg/kg) and then was executed a random-pattern skin flap paradigm. Also, spermidine at the dose of 5 mg/kg was selected and one group rats received spermidine 20 min prior to surgery and one additional dose 1 day after operation. Then, 7 days after operations, interleukin (IL)-6, tumor necrosis factor (TNF)-α, interferon-gamma (IFN-γ), and nitrite levels were inquired in the tissue samples by ELIZA kit. Vascular endothelial growth factor expression was assessed by DAPI staining and fluorescent microscopes. The concentrations of three polyamines, including spermidine, spermine, and cadaverine, were analyzed using HPLC., Results: Pretreatment with spermidine 5 mg/kg improved SFS considerably in microscopic skin H&E staining analysis and decreased the percentage of necrotic area. Moreover, spermidine exerted promising anti-inflammatory effects via the modulation of nitric oxide and reducing inflammatory cytokines., Conclusions: Spermidine could improve skin flaps survival, probably through the nitrergic system and inflammation pathways. This preclinical study provides level III evidence for the potential therapeutic effects of spermidine on SFS in rats, based on the analysis of animal models. Further studies are needed to confirm these findings in clinical settings., Level of Evidence Iii: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 ., (© 2024. Springer Science+Business Media, LLC, part of Springer Nature and International Society of Aesthetic Plastic Surgery.)
Published: 2024
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20. Effects of Gap 26, a Connexin 43 Inhibitor, on Cirrhotic Cardiomyopathy in Rats.

Author: Mohammed D, Tavangar SM, Khodadoostan A, Mousavi SE, Dehpour AR, and Jazaeri F
Abstract: Introduction Cirrhotic cardiomyopathy (CCM) is recognized by impaired cardiac responsiveness to stress, prolonged QT interval, and systolic and diastolic dysfunctions. Connexins are a family of transmembrane proteins that play a key role in cardiac physiology. Connexin 43 (Cx43) inhibition showed cardio-protective effects. Peptide drug Cx43 inhibitor, Gap 26, could inhibit gap junction 43. This study was designed to evaluate the effects of a connexin mimetic peptide, Gap 26, in the CCM model in rats. Methods The cirrhosis was induced through carbon tetrachloride (CCl4). On day 56, electrocardiography (ECG) was recorded, spleen weight was measured, and tissue and serum samples were collected. Further, Cx43 mRNA expression in heart tissue was checked. Results The chronotropic responses decreased in the CCl4/saline and increased in the CCl4/Gap. The spleen weight, QTc interval, and brain natriuretic peptide (BNP), tumor necrosis factor-alpha (TNF-α), aspartate aminotransferase (AST), alanine transaminase (ALT), and malondialdehyde (MDA) levels elevated in the CCl4/saline, and the spleen weight, QTc interval, and MDA and ALT levels were reduced by Gap 26 treatment. The level of nuclear factor (erythroid-derived 2) factor 2 (Nrf2) decreased in the CCl4/saline. The Cx43 expression was downregulated in the CCl4/saline and upregulated with the Gap 26 treatment. Conclusion Gap 26 not only alleviated the chronotropic hyporesponsiveness and the severity of liver damage and upregulated the atrial Cx43 expression, but it also had an antioxidant effect on the heart., Competing Interests: The authors have declared that no competing interests exist., (Copyright © 2024, Mohammed et al.)
Published: 2024
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21. Ivermectin ameliorates bleomycin-induced lung fibrosis in male rats by inhibiting the inflammation and oxidative stress.

Author: Habibi Razi F, Mohammad Jafari R, Manavi MA, Sheibani M, Rashidian A, Tavangar SM, Beighmohammadi MT, and Dehpour AR
Subjects: Rats, Male, Animals, Bleomycin adverse effects, Ivermectin adverse effects, Tumor Necrosis Factor-alpha metabolism, Rats, Wistar, Inflammation chemically induced, Inflammation drug therapy, Inflammation pathology, Lung metabolism, Oxidative Stress, Transforming Growth Factor beta, Glutathione metabolism, Superoxide Dismutase metabolism, Pulmonary Fibrosis chemically induced, Pulmonary Fibrosis drug therapy, Pulmonary Fibrosis prevention & control
Abstract: Background: Idiopathic pulmonary fibrosis (IPF) is a pulmonary fibrotic disease characterized by a poor prognosis, which its pathogenesis involves the accumulation of abnormal fibrous tissue, inflammation, and oxidative stress. Ivermectin, a positive allosteric modulator of GABA A receptor, exerts anti-inflammatory and antioxidant properties in preclinical studies. The present study investigates the potential protective effects of ivermectin treatment in rats against bleomycin-induced IPF., Materials and Methods: The present study involved 42 male Wistar rats, which were divided into five groups: control (without induction of IPF), bleomycin (IPF-induced by bleomycin 2.5 mg/kg, by intratracheal administration), and three fibrosis groups receiving ivermectin (0.5, 1, and 3 mg/kg). lung tissues were harvested for measurement of oxidative stress [ via myeloperoxidase (MPO), superoxide dismutase (SOD), glutathione (GSH)] and inflammatory markers (tumor necrosis factor-α [TNF-α], interleukin-1β [IL-1β], and transforming growth factor-β [TGF-β]). Histological assessments of tissue damage were performed using hematoxylin-eosin (H&E) and Masson's trichrome staining methods., Results: The induction of fibrosis via bleomycin was found to increase levels of MPO as well as TNF-α, IL-1β, and TGF-β while decrease SOD activity and GSH level. Treatment with ivermectin at a dosage of 3 mg/kg was able to reverse the effects of bleomycin-induced fibrosis on these markers. In addition, results from H&E and Masson's trichrome staining showed that ivermectin treatment at this same dose reduced tissue damage and pulmonary fibrosis., Conclusion: The data obtained from this study indicate that ivermectin may have therapeutic benefits for IPF, likely due to its ability to reduce inflammation and mitigate oxidative stress-induced toxicity.
Published: 2024
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22. Empty sella in somatotropic pituitary adenomas; a series of 23 cases.

Author: Sharifi G, Mohammadi E, Paraandavaji E, Tavangar SM, Dabbagh Ohadi MA, Jafari A, Jahanbakhshi A, Akbari Dilmaghani N, Davoudi Z, Smith TR, Banihashemi G, Azadi M, Hatami N, Zenonos GA, and Mohajeri Tehrani M
Abstract: Purpose: We aimed to investigate empty sella syndrome in somatotrophic pituitary adenoma for possible etiology, complications, and treatment options., Method: Among over 2,000 skull base masses that have been managed in our center since 2013, we searched for growth hormone-producing adenomas. Clinical, surgical, and imaging data were retrospectively collected from hospital records to check for sella that lacked pituitary tissue on routine imaging., Result: In 220 somatotrophic adenomas, 23 patients had an empty sella with surgical and follow-up data. The mean age of the sample was 46 years with the same male-to-female ratio. Five cases had partial empty sella and the rest were complete empty sellas. The most common simultaneous hormonal disturbance was high prolactin levels. Six had adenoma invasion into the clivus or sphenoid sinus and 10 had cavernous sinus intrusion. Peri-operative low-flow and high-flow cerebrospinal fluid (CSF) leaks were encountered in one and two patients, respectively, which were successfully sealed by abdominal fat. The majority of cases required growth hormone replacement therapy while it was controlled without any replacement therapy in nine patients. No pituitary hormonal disturbance occurred after transsphenoidal surgery except for hypothyroidism in one patient., Conclusion: An empty sella filled with fluid can be detected frequently in pituitary adenomas, especially in the setting of acromegaly. The pituitary gland may be pushed to the roof of the sella and might be visible as a narrow rim on imaging or may be detected in unusual places out of the sella. The pathophysiology behind such finding originates from soft and hard tissue changes and CSF pressure alternations during abundant growth hormone production., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (© 2024 Sharifi, Mohammadi, Paraandavaji, Tavangar, Dabbagh Ohadi, Jafari, Jahanbakhshi, Akbari Dilmaghani, Davoudi, Smith, Banihashemi, Azadi, Hatami, Zenonos, and Mohajeri Tehrani.)
Published: 2024
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23. Safety and hemostatic effect of Achillea millefolium L. in localized bleeding.

Author: Bagheri A, Amin G, Tavangar SM, Heidari M, and Bagheri J
Abstract: Background and Aim: This study aims to demonstrate the hemostatic effect of the hydroalcoholic extract of Achillea millefolium L. in localized bleeding and to assess the safety of its topical application on rat liver., Materials and Methods: The aerial parts of A. millefolium were macerated in methanol for two days. Twelve female Wistar rats, weighing 120-220 g, underwent anesthesia and laparotomy. The liver was exposed, and two incisions were made to induce bleeding. One incision was treated with a sponge soaked in A. millefolium extract, while the other served as a control. The animals were divided into two groups: in one, A. millefolium (150 mg/kg) was applied to the first incision, and in the other, to the second incision. Liver biopsies were collected after 4, 6, and 8 weeks., Results: Application of A. millefolium to liver incisions, whether first or second, significantly reduced bleeding time (by 36.1% and 31.9%, respectively). Histopathological analysis showed no signs of toxicity or hepatic damage after 4, 6, and 8 weeks in the female rats., Conclusion: The study confirms the hemostatic effect of the hydroalcoholic extract of A. millefolium in localized bleeding and establishes its safety for topical use., Competing Interests: The authors have no conflict of interest to declare., (© Copyright 2024 by Hepatology Forum.)
Published: 2024
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24. The Association of Oral Microbiome Dysbiosis with Gastrointestinal Cancers and Its Diagnostic Efficacy.

Author: Asili P, Mirahmad M, Rezaei P, Mahdavi M, Larijani B, and Tavangar SM
Subjects: Humans, Dysbiosis diagnosis, Dysbiosis microbiology, Bacteria, Biomarkers, Microbiota, Esophageal Neoplasms
Abstract: Background: The second leading mortality cause in the world is cancer, making it a critical issue that impacts human health. As a result, scientists are looking for novel biomarkers for cancer detection. The oral microbiome, made up of approximately 700 species-level taxa, is a significant source for discovering novel biomarkers. In this review, we aimed to prepare a summary of research that has investigated the association between the oral microbiome and gastrointestinal cancers., Methods: We searched online scientific datasets including Web of Science, PubMed, Scopus, and Google Scholar. Eligibility criteria included human studies that reported abundances of the oral microbiome, or its diagnostic/prognostic performance in patients with gastrointestinal cancers., Results: Some phyla of the oral microbiome have a relationship with cancers. Some particular phyla of the oral microbiome that may be related to gastrointestinal cancers consist of Firmicutes, Actinobacteria, Bacteroidetes, Proteobacteria, and Fusobacteria. Changes in the abundances of Porphyromonas, Fusobacterium, Prevotella, and Veillonella are correlated with carcinogenesis, and may be used for distinguishing cancer patients from healthy subjects. Oral, colorectal, pancreatic, and esophageal cancers are the most important cancers related to the oral microbiome., Conclusion: The results of this study may help future research to select bacteria as an early diagnostic or prognostic biomarker of gastrointestinal cancer. Given the current state of our knowledge, additional research is required to comprehend the multiplex processes underlying the role of bacterial microbiota upon cancer progression and to characterize the complex microbiota-host interaction network., (© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Published: 2023
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25. National and subnational burden of leukemia and its risk factors, 1990-2019: Results from the Global Burden of Disease study 2019.

Author: Poopak A, Saeedi Moghaddam S, Esfahani Z, Keykhaei M, Rezaei N, Rezaei N, Rashidi MM, Ahmadi N, Abbasi-Kangevari M, Malekpour MR, Ghamari SH, Djalalinia S, Tavangar SM, Larijani B, and Kompani F
Subjects: Humans, Global Burden of Disease, Quality-Adjusted Life Years, Bayes Theorem, Life Expectancy, Risk Factors, Global Health, Neoplasms epidemiology, Leukemia epidemiology
Abstract: Background: Hematologic malignancies have a great essential role in cancer global burden. Leukemia which two major subtypes based on the onset, is one of the common subtypes of this malignancy., Method: For the GBD 2019 study, cancer registry data and vital registration system were used to estimate leukemia mortality. The Meta-Regression-Bayesian Regularized Trimmed (MR-BRT), Cause of Death Ensemble model (CODEm) and Spatiotemporal Gaussian Process Regression (ST-GPR) were used to model our data and estimate each quantity of interest. Mortality to incidence ratios (MIR) were used to generate incidence and survival from mortality rate. Prevalence and survival were used to generate years lived with disability (YLDs). Age-specific mortality and life expectancy at the same age were used to estimate years of life lost (YLLs). The sum of YLLs and YLDs generates DALYs., Results: The total national incidence of leukemia increased from 6092 (UI 95%: 3803-8507) in 1990 to 6767 (4646-7890) new cases in 2019. However, leukemia age-standardized incidence ratio(ASIR) decreased from 11.6 (8-14.8) to 8.9 (6.2-10.3) new cases per 100,000 in this exact period. At the national level, deaths from leukemia increased 1.5-fold between 1990 and 2019, from 3287 (2284-4201) to 4424 (3137-5030), whereas the age-standardized death rate(ASDR) decreased from 8.3 (6.1-9.8) in 1990 to 6 (4.3-6.8) per 100,000 in 2019. In the study period, total leukemia DALYs decreased 12.2% and reached 162850 (110681-188806), in 2019. The age-standardized DALYs decreased 36.7% from 324.3 (224.8-413.4) in 1990 to 205.3 (140.3-237.8) in 2019. ASDR, DALYs, YLLs, and YLDs rate to high BMI was increasing while smoking and occupational exposure to benzene and formaldehyde were decreasing in the study period., Conclusion: This study provided a better understanding of leukemia burden and to reduce controversies of leukemia across Iran. The leukemia status alteration of the country, is trackable., Competing Interests: The authors have declared that no competing interests exist., (Copyright: © 2023 Poopak et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Published: 2023
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26. Spermidine reduced neuropathic pain in chronic constriction injury-induced peripheral neuropathy in rats.

Author: Yousefi-Manesh H, Shirooie S, Noori T, Sheibani M, Tavangar SM, Hemmati S, Sadeghi MA, Akbarniakhaky H, Mohammadi Z, Foroutani L, and Dehpour AR
Subjects: Rats, Male, Animals, Constriction, Pain Threshold, Sciatic Nerve, Hyperalgesia drug therapy, Hyperalgesia etiology, Spermidine pharmacology, Neuralgia drug therapy, Neuralgia etiology
Abstract: Neuropathic pain is one of the most critical types of chronic pain despite the increasing advances in medical science. Spermidine (SPD) is a natural polyamine that has wide roles in several cellular processes inducing autophagy and reducing oxidative stress. This study aimed to investigate the effects of SPD on oxidative stress markers and pain threshold in the neuropathic rat model of chronic constriction injury (CCI) model. Eighteen adult male rats were divided into three groups: sham, CCI and CCI+SPD. After induction of neuropathy via CCI model in the CCI and CCI+SPD groups, SPD (1 mg/kg/day, orally) was administered to the CCI+SPD group for 3 weeks. The behavioral tests (von Frey, hot plate) were done four times during the experiment. At the end of the study, electrophysiological tests, the H & E staining, and oxidative stress assay of the prefrontal cortex (PFC), spinal cord, and sciatic nerve were performed. The threshold of pain in hot plate and von Frey tests was significantly lower in the CCI group than in the sham group, which was reversed by SPD treatment in the CCI+ SPD group. In addition, nerve conduction was considerably lower in the CCI group than in the sham and CCI+SPD groups (P < 0.01, P < 0.05, respectively). The CCI group showed neuronal degeneration and fibrosis in the different tissues in the H & E assay; elevated tissues level of nitrite, decreased levels of superoxide dismutase (SOD), glutathione (GPx), and catalase were also observed. However, SPD treatment modulated the pathological changes and oxidative stress biomarkers. In conclusion, SPD showed beneficial effects in decreasing neuropathic pains. SPD treatment reduced oxidative stress and improved histopathological changes and behavioral tests in the CCI-induced neuropathic pain in in vivo model., (© 2023 Société Française de Pharmacologie et de Thérapeutique.)
Published: 2023
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27. Practice of IDH1, ATRX, and P53 Immunohistochemistry in Integrated Diagnosis of Adult Diffuse Gliomas: Single Center Study.

Author: Shabanzadeh Nejabad Z, Mabroukzadeh Kavari H, Saffar H, Tavangar SM, Sefidbakht S, Khoshnevisan A, Zare-Mirzaie A, Vasei M, Jafari E, Yaghmaii M, and Saffar H
Subjects: Humans, Tumor Suppressor Protein p53 genetics, Immunohistochemistry, X-linked Nuclear Protein genetics, Mutation, Chromosome Aberrations, Isocitrate Dehydrogenase genetics, Isocitrate Dehydrogenase metabolism, Brain Neoplasms diagnosis, Brain Neoplasms genetics, Brain Neoplasms pathology, Glioma diagnosis, Glioma genetics, Glioma pathology, Glioblastoma pathology, Oligodendroglioma diagnosis, Oligodendroglioma genetics, Oligodendroglioma pathology
Abstract: Diffuse gliomas exhibit different molecular and genetic profiles with a wide range of heterogeneity and prognosis. Recently, molecular parameters including ATRX, P53, and IDH mutation status or absence or presence of 1p/19q co-deletion have become a crucial part of the diagnosis of diffuse glioma. In the present study, we tried to analyze the routine practice of the above-mentioned molecular markers focusing on the IHC method in cases of adult diffuse gliomas to evaluate their utility in the integrated diagnosis of adult diffuse gliomas. In total, 134 cases of adult diffuse glioma were evaluated. Using the IHC method, 33,12, and 12 cases of IDH mutant Astrocytoma grade 2, 3, 4, and 45 cases of gliobalstoma, IDH wild type, were molecularly diagnosed. By adding the FISH study for 1p/19q co-deletion, 9 and 8 cases of oligodendroglioma grade 2 and 3 also were included. Two IDH mutant cases were negative for IDH1 in IHC but revealed a positive mutation in further molecular testing. Finally, we were not able to incorporate a complete integrated diagnosis in 16/134(11.94%) of cases. The main molecularly unclassified group was histologically high-grade diffuse glial tumors in patients less than 55 years old and negative IDH1 immunostaining. P53 was positive in 23/33 grade 2, 4/12 grade 3, and 7/12 grade 4 astrocytomas, respectively. Four out of 45 glioblastomas showed positive immunostain, and all oligodendrogliomas were negative. In conclusion, a panel of IHC markers for IDH1 R132H, P53, and ATRX significantly improves the molecular classification of adult diffuse gliomas in daily practice and can be used as a tool to select limited cases for co-deletion testing in the low resources area., Competing Interests: The authors declare no conflict of interest., (Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.)
Published: 2023
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28. The 15-year national trends of endocrine cancers incidence among Iranian men and women; 2005-2020.

Author: Balajam NZ, Mousavian AH, Sheidaei A, Gohari K, Tavangar SM, Ghanbari-Motlagh A, Ostovar A, Shafiee G, and Heshmat R
Subjects: Male, Adolescent, Humans, Female, Incidence, Iran epidemiology, Registries, Endocrine Gland Neoplasms, Neoplasms epidemiology, Thyroid Neoplasms epidemiology, Adrenal Gland Neoplasms
Abstract: Cancer is one of the important health problems in Iran, which is considered as the third cause of death. Endocrine cancers are rare but mostly curable. Thyroid cancer, the most common endocrine tumors, includes about one percent of malignant cancer. In this study, we examined the 15-year national trend of endocrine cancer incidence in Iranian men and women. The data in each province were evaluated based on age, gender, and cancer type according to International Classification of Disease Codes version 10 (ICD-10) from 2005 to 2020 in Iran. All data were obtained from the reports of the Statistics Center of Iran (SCI), 6 phases of the step-by-step approach to monitoring the risk factors of chronic diseases over 18 years old (STEPs), and 3 periods of the CASPIAN study (survey of non-communicable diseases in childhood and adolescence). Statistical analyzes and graph generation were done using R statistical software. Poisson regression with mixed effects was used for data modeling and incidence rate estimation. The incidence of thyroid gland malignancy is higher in women than in men. On the other hand, the incidence of adrenal gland cancer is slightly higher in men than in women. The same pattern is observed for other endocrine neoplasms and related structures. The incidence rate of these types of cancers has generally increased from 2005 to 2020 in Iran. This increase is more in women than in men. In addition, in the middle of the country, there is a strong region in terms of the occurrence of these types of cancers. The incidence rate in these provinces is relatively higher for both sexes and all studied periods. We conducted a study to observe the changing trends for various types of endocrine cancers over 15 years in men and women. Considering the increasing trend of thyroid cancers in Iran, therefore, creating essential policies for the management of these types of cancers for prevention, rapid diagnosis, and, timely treatment is particularly important., (© 2023. The Author(s).)
Published: 2023
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29. Single-cell transcriptome analysis for cancer and biology of the pancreas: A review on recent progress.

Author: Tamaddon M, Azimzadeh M, Gifani P, and Tavangar SM
Abstract: Single-cell sequencing has become one of the most used techniques across the wide field of biology. It has enabled researchers to investigate the whole transcriptome at the cellular level across tissues, which unlocks numerous potentials for basic and applied studies in future diagnosis and therapy. Here, we review the impact of single-cell RNA sequencing, as the prominent single-cell technique, in pancreatic biology and cancer. We discuss the most recent findings about pancreatic physiology and pathophysiology owing to this technological advancement in the past few years. Using single-cell RNA sequencing, researchers have been able to discover cellular heterogeneity across healthy cell types, as well as cancer tissues of the pancreas. We will discuss the new immunological targets and new molecular mechanisms of progression in the microenvironment of pancreatic cancer studied using single-cell RNA sequencing. The scope is not limited to cancer tissues, and we cover novel developmental, evolutionary, physiological, and heterogenic insights that have also been achieved recently for pancreatic tissues. We cover all biological insights derived from the single-cell RNA sequencing data, discuss the corresponding pros and cons, and finally, conclude how future research can move better by utilizing single-cell analysis for pancreatic biology., Competing Interests: PG was employed by AI VIVO Ltd. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Tamaddon, Azimzadeh, Gifani and Tavangar.)
Published: 2023
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30. A Case Report of Cushing's Disease Presenting With Psychosis and Muscle Weakness Postpartum.

Author: Eskandari D, Ziaee A, Samadanifard SH, Tavangar SM, Tirkan A, and ZaeimYekeh MA
Subjects: Adult, Female, Humans, Hydrocortisone, Muscle Weakness, Postpartum Period, Cushing Syndrome complications, Cushing Syndrome diagnosis, Pituitary ACTH Hypersecretion complications, Psychotic Disorders diagnosis, Psychotic Disorders etiology
Abstract: Cushing's syndrome is a condition leading to overproducing of cortisol by the adrenal glands. If the pituitary gland overproduces cortisol, it is called Cushing's disease. Cushing's syndrome and even Cushing's disease during and after pregnancy are rare events. There is not enough literature and guidance for managing and treating these patients. The diagnosis of Cushing's syndrome in pregnancy is often delayed because the symptoms overlap. We presented a thin 31-year-old woman, admitted 2 months after a normal-term delivery, with an atypical presentation of Cushing's disease, unusual clinical features, and a challenging clinical course. She had no clinical discriminatory features of Cushing's syndrome. Given that the patient only presented with psychosis and proximal myopathy and had an uncomplicated pregnancy, our case was considered unusual. The patients also had hyperpigmentation and severe muscle weakness which are among the less common presentations of Cushing's syndrome. Our findings suggest that an early diagnosis of Cushing's disease is important in pregnancy period for its prevalent fetal and maternal complications, and it should be treated early to optimize fetal and maternal outcomes as there is an increasing trend toward live births in treated participants., Competing Interests: Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Published: 2023
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31. Cannabidiol Improves Random-Pattern Skin Flap Survival in Rats: Involvement of Cannabinoid Type-2 Receptors.

Author: Aryannejad A, Eslami F, Shayan M, Noroozi N, Hedayatyanfard K, Tavangar SM, Jafari RM, and Dehpour AR
Subjects: Rats, Male, Animals, Receptors, Cannabinoid, Rats, Wistar, Drug Inverse Agonism, Cannabidiol pharmacology
Abstract: Background: One of the major complications associated with random-pattern skin flaps is distal necrosis. Cannabidiol (CBD) has recently gained much attention as a therapeutic anti-inflammatory agent. We aimed to evaluate the efficacy of CBD on the random-pattern skin flap survival (SFS) in rats and to explore the possible involvement of cannabinoid type-2 (CB2) receptors., Methods: In this controlled experimental study, we randomly divided male Wistar rats into seven study groups (six rats each). We performed a random-pattern skin flap model in each rat following pretreatment with vehicle (control) or multiple doses of CBD (0.3, 1, 5, or 10 mg/kg). In a separate group, we injected SR144528 (2 mg/kg), a high affinity and selective CB2 inverse agonist, before the most effective dose of CBD (1 mg/kg). A sham nontreated and nonoperated group was also included. Seven days after surgeries, the percentage of necrotic area (PNA) was calculated. Histopathological microscopy, CB2 expression level, and interleukin (IL)-1β and tumor necrosis factor (TNF)-α concentrations were also investigated in the flap tissue samples., Results: A PNA of 72.7 ± 7.5 (95% confidence interval [CI]: 64.8-80.6) was captured in the control group. Following treatment with CBD 0.3, 1, 5, and 10 mg/kg, a dose-dependent effect was observed with PNAs of 51.0 ± 10.0 (95% CI: 40.5-61.5; p <0.05), 15.4 ± 5.8 (95% CI: 9.3-21.5; p <0.001), 37.1 ± 10.2 (95% CI: 26.3-47.8; p <0.001), and 46.4 ± 14.0 (95% CI: 31.7-61.1; p <0.001), respectively. Histopathologically, tissues enhanced significantly. Besides, CB2 expression surged remarkably, IL-1β and TNF-α concentrations decreased considerably after treatment with CBD of 1 mg/kg compared with the control ( p <0.05 and <0.001, respectively). Administering SR144528 reversed the favorable effects of CBD of 1 mg/kg, both macroscopically and microscopically., Conclusion: Pretreatment with CBD of 1 mg/kg improved SFS considerably in rats and exerted desirable anti-inflammatory effects which were possibly mediated by CB2 receptors., Competing Interests: None declared.A.R.D. reports that this study was supported by a grant from the Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran (grant no. 99-3-209-49168).R.M.J. reports that this study was supported by a grant from the Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran (grant no. 99-3-209-49168).S.M.T. reports that this study was supported by a grant from the Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran (grant no. 99-3-209-49168).K.H. reports that this study was supported by a grant from the Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran (grant no. 99-3-209-49168).N.N. reports that this study was supported by a grant from the Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran (grant no. 99-3-209-49168).M.S. reports that this study was supported by a grant from the Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran (grant no. 99-3-209-49168).F.E. reports that this study was supported by a grant from the Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran (grant no. 99-3-209-49168).A.A. reports that this study was supported by a grant from the Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran (grant no. 99-3-209-49168)., (Thieme. All rights reserved.)
Published: 2023
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32. Evaluation of statins as a new therapy to alleviate chronotropic dysfunction in cirrhotic rats.

Author: Niaz Q, Tavangar SM, Mehreen S, Ghazi-Khansari M, and Jazaeri F
Subjects: Animals, Male, Rats, Anti-Inflammatory Agents therapeutic use, Antioxidants metabolism, Atorvastatin metabolism, Cholesterol metabolism, Fibrosis, Ligation, Liver metabolism, Liver Cirrhosis pathology, Malondialdehyde metabolism, Natriuretic Peptides metabolism, NF-E2-Related Factor 2 metabolism, Rats, Wistar, rhoA GTP-Binding Protein metabolism, Tumor Necrosis Factor-alpha metabolism, Hydroxymethylglutaryl-CoA Reductase Inhibitors therapeutic use, Nitric Oxide Synthase Type III metabolism
Abstract: Aims: Liver cirrhosis defines by regenerative nodules and fibrotic septa, causing a complication called cirrhotic cardiomyopathy (CCM) with chronotropic hypo-responsiveness. In addition to lowering cholesterol levels, statins yield antioxidant and anti-inflammatory effects. In liver diseases animal models, statins have been shown to decrease hepatic inflammation, fibrogenesis, and portal pressure (PP). Therefore, we evaluated the atorvastatin effect on the heart in cirrhotic rats., Materials and Methods: Bile duct ligation (BDL) or sham operation performed on male Wistar rats and grouped as cirrhotic; BDL/Saline, BDL/Ator-7d(days) (Atorvastatin 15 mg/kg/day), and BDL/Ator-14d groups, or control; Sham/Saline, Sham/Ator-7d, and Sham/Ator-14d groups. Corrected QT interval (QTc interval), chronotropic responses, serum brain natriuretic peptides (BNP), heart tumor necrosis factor-α (TNF-α), nuclear factor erythroid 2-related factor 2 (Nrf2), and malondialdehyde (MDA) levels were studied along with atrial Ras homolog family member A (RhoA) and endothelial nitric oxide synthase (eNOS) gene expression., Key Findings: The chronotropic responses decreased in BDL/Saline and increased in BDL/Ator-7d group. The QTc interval, BNP, TNF-α, and MDA levels increased in BDL/Saline and decreased in BDL/Ator-14d group. The Nrf2 level did not change in BDL/Saline and increased in BDL/Ator-14d group. The liver inflammation and fibrosis increased in BDL/Saline and did not affect BDL/Ator-7d and BDL/Ator-14d groups. The RhoA expression was down-regulated in BDL/Saline, BDL/Ator-7d, and BDL/Ator-14d groups. The eNOS expression did not change in BDL/Saline and down-regulated in BDL/Ator-14d group., Significance: Atorvastatin alleviates the chronotropic hypo-responsiveness and down-regulates the atrial RhoA and eNOS gene expression along with anti-inflammatory, antioxidant, and anti-stress effects in CCM., Competing Interests: Conflict of interest statement The authors declare no conflicts of interest related to this work or its publication., (Copyright © 2022. Published by Elsevier Inc.)
Published: 2022
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33. The role of HER2 alterations in clinicopathological and molecular characteristics of breast cancer and HER2-targeted therapies: a comprehensive review.

Author: Asgari-Karchekani S, Aryannejad A, Mousavi SA, Shahsavarhaghighi S, and Tavangar SM
Subjects: Female, Hormones, Humans, Phosphatidylinositol 3-Kinases, Proto-Oncogene Proteins c-akt, TOR Serine-Threonine Kinases, Tyrosine, Breast Neoplasms drug therapy, Breast Neoplasms genetics
Abstract: Breast cancer (BC) is the most common malignancy in women and one of the leading causes of cancer mortality, despite significant treatment advancements over the last decades. Human epidermal growth factor receptor-2 (HER2) is a member of the ERBB family of receptor tyrosine kinases which have long been known to mediate cancer cell growth and invasion through constitutive activation of oncogenic downstream signaling, such as PI3K/Akt/mTOR and MAPK. Overexpression/amplification of HER2 in various tumors, especially BC, offers the possible therapeutic potential for target therapies. HER2-targeted therapies, either with a combination of chemotherapy or through multi-anti-HER2 therapies without chemotherapy, have significantly improved the prognosis of HER2-positive tumors. In recent years, novel anti-HER2 agents and combination therapies have garnered much attention, especially for heavily treated advanced or metastatic BCs. HER2-positive BC is biologically a heterogeneous group depending on HER2 activation mechanisms, hormone receptor status, genome variations, tumor heterogeneity, and treatment resistance, which affect the treatment benefit and patients' outcomes. This review will discuss HER2 alternations (gene amplification or receptor overexpression) in BC, their correlation with clinicopathological characteristics and molecular characteristics, and HER2-based therapies in tumors with HER2 overexpression/amplification., (© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Published: 2022
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34. Burden of thyroid cancer in North Africa and Middle East 1990-2019.

Author: Nejadghaderi SA, Moghaddam SS, Azadnajafabad S, Rezaei N, Rezaei N, Tavangar SM, Jamshidi H, Mokdad AH, Naghavi M, Farzadfar F, and Larijani B
Abstract: Background: Thyroid cancer is the leading cause of mortality and morbidity among cancers of the endocrine system. We aimed to describe the trends of thyroid cancer burden in North Africa and Middle East for 1990-2019., Methods: Data on burden of thyroid cancer in North Africa and Middle East from 1990 to 2019 were obtained from the Global Burden of Disease (GBD) Study 2019. Decomposition analysis was used to estimate the effects of population growth, aging, and change in incident numbers on overall change of thyroid cancer incidence. Also, we used the comparative risk assessment framework of GBD to determine the burden of thyroid cancer attributable to a high body mass index (BMI)., Results: In 2019, the age-standardized incidence rate (ASIR) and age-standardized mortality rate (ASMR) of thyroid cancer were 3.5 (2.9-4) and 0.5 (0.5-0.7) per 100,000, respectively. The highest age-standardized incidence, deaths, and disability-adjusted life year (DALY) rate were in Lebanon, Afghanistan, and United Arab Emirates, respectively. The ASIR of thyroid cancer in region was about 2.5 times higher among women, which had a positive association with increasing age. In 2019, the age-standardized deaths attributable to a high BMI was 16.7% of all deaths due to thyroid cancer. In 1990-2019, the overall change in thyroid cancer incident cases was a 396% increase which was mostly driven by the increase in disease-specific incidence rate (256.8%)., Conclusions: Women, the elderly above about 60 years old, and countries with a higher sociodemographic index showed higher incidence rates of thyroid cancer. Regarding our findings, it is recommended to establish preventive plans by modification in life style like weight reduction programs., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Nejadghaderi, Moghaddam, Azadnajafabad, Rezaei, Rezaei, Tavangar, Jamshidi, Mokdad, Naghavi, Farzadfar and Larijani.)
Published: 2022
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35. National, sub-national, and risk-attributed burden of thyroid cancer in Iran from 1990 to 2019.

Author: Azangou-Khyavy M, Saeedi Moghaddam S, Rezaei N, Esfahani Z, Rezaei N, Azadnajafabad S, Rashidi MM, Mohammadi E, Tavangar SM, Jamshidi H, Mokdad AH, Naghavi M, Farzadfar F, and Larijani B
Subjects: Body Mass Index, Global Health, Humans, Incidence, Iran epidemiology, Quality-Adjusted Life Years, Risk Factors, Global Burden of Disease, Thyroid Neoplasms epidemiology
Abstract: An updated exploration of the burden of thyroid cancer across a country is always required for making correct decisions. The objective of this study is to present the thyroid cancer burden and attributed burden to the high Body Mass Index (BMI) in Iran at national and sub-national levels from 1990 to 2019. The data was obtained from the GBD 2019 study estimates. To explain the pattern of changes in incidence from 1990 to 2019, decomposition analysis was conducted. Besides, the attribution of high BMI in the thyroid cancer DALYs and deaths were obtained. The age-standardized incidence rate of thyroid cancer was 1.57 (95% UI: 1.33-1.86) in 1990 and increased 131% (53-191) until 2019. The age-standardized prevalence rate of thyroid cancer was 30.19 (18.75-34.55) in 2019 which increased 164% (77-246) from 11.44 (9.38-13.85) in 1990. In 2019, the death rate, and Disability-adjusted life years of thyroid cancer was 0.49 (0.36-0.53), and 13.16 (8.93-14.62), respectively. These numbers also increased since 1990. The DALYs and deaths attributable to high BMI was 1.91 (0.95-3.11) and 0.07 (0.04-0.11), respectively. The thyroid cancer burden and high BMI attributed burden has increased from 1990 to 2019 in Iran. This study and similar studies' results can be used for accurate resource allocation for efficient management and all potential risks' modification for thyroid cancer with a cost-conscious view., (© 2022. The Author(s).)
Published: 2022
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36. The role of saffron in improvement of ocular surface disease in a mouse model of Lacrimal Gland Excision-induced dry eye disease.

Author: Yousefi-Manesh H, Aghamollaei H, Dehpour AR, Sheibani M, Tavangar SM, Bagheri M, Shirooie S, Daryabari SH, and Noori T
Subjects: Animals, Anti-Inflammatory Agents pharmacology, Anti-Inflammatory Agents therapeutic use, Betamethasone pharmacology, Betamethasone therapeutic use, Disease Models, Animal, Fluorescein, Mice, Tears, Crocus, Dry Eye Syndromes pathology, Lacrimal Apparatus pathology
Abstract: One of the most prevalent eye disorders is dry eye disease (DED), described by ocular dryness due to the tear insufficiency. Prolonged dry eye causes damage and ulcer to the surface of the cornea. The core of the DED mechanism is inflammation which is a biological response of the body to pathogens. Several studies have indicated that saffron has many beneficial biological effects, such as anti-inflammatory and free radical scavenging. This research aims to examine possible positive impact of saffron in the mice model of DED. The animals were divided into 4 groups. Induction of DED was done by right Lacrimal Gland Excision (LGE). Treatment was done by intraperitoneal (i.p.) injection of saffron (1 mg/kg/day, for 28 days after induction of DED) in the SAF group, betamethasone (the BET group) (i.p., 1 mg/kg/day, for 28 days after induction of DED), the LGE group (received normal saline i.p. for 28 days after induction of DED) and the sham group (no induction of DED). Ophthalmological assay with fluorescein staining on the 0, 14 and, 28 days, histopathological analysis (H & E assay) on the last day and, pro-inflammatory cytokine assays of eyes were done. Saffron and betamethasone reduced the fluorescein score of the eyes (P < 0.0001) and improved the ocular surface disease in H & E assay as well as reduced the eye levels of TNF-α (P < 0.01), IL-1β (P < 0.0001) and, IL-6 (P < 0.001) compared to those of the LGE group. The current study indicated that treatment with saffron has a beneficial effect on LGE (Lacrimal gland excision)-induced DED in mice via its anti-inflammatory properties., (Copyright © 2022 Elsevier Ltd. All rights reserved.)
Published: 2022
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37. Sildenafil improves radiation-induced oral mucositis by attenuating oxidative stress, NF-κB, ERK and JNK signalling pathways.

Author: Ala M, Mohammad Jafari R, Ala M, Hejazi SM, Tavangar SM, Mahdavi SR, and Dehpour AR
Subjects: Animals, Apoptosis, Oxidative Stress, Rats, Sildenafil Citrate pharmacology, Sildenafil Citrate therapeutic use, NF-kappa B metabolism, Stomatitis drug therapy, Stomatitis etiology, Stomatitis metabolism
Abstract: Radiation-induced oral mucositis is a common and dose-limiting complication of head and neck radiotherapy with no effective treatment. Previous studies revealed that sildenafil, a phosphodiesterase 5 inhibitor, has anti-inflammatory and anti-cancer effects. In this study, we investigated the effect of sildenafil on radiation-induced mucositis in rats. Two doses of radiation (8 and 26 Gy X-ray) were used to induce low-grade and high-grade oral mucositis, separately. A control group and three groups of sildenafil citrate-treated rats (5, 10, and 40 mg/kg/day) were used for each dose of radiation. Radiation increased MDA and activated NF-κB, ERK and JNK signalling pathways. Sildenafil significantly decreased MDA level, nitric oxide (NO) level, IL1β, IL6 and TNF-α. The most effective dose of sildenafil was 40 mg/kg/day in this study. Sildenafil also significantly inhibited NF-κB, ERK and JNK signalling pathways and increased bcl2/bax ratio. In addition, high-dose radiation severely destructed the mucosal layer in histopathology and led to mucosal cell apoptosis in the TUNEL assay. Sildenafil significantly improved mucosal structure and decreased inflammatory cell infiltration after exposure to high-dose radiation and reduced apoptosis in the TUNEL assay. These findings show that sildenafil can improve radiation-induced oral mucositis and decrease the apoptosis of mucosal cells via attenuation of inflammation and oxidative stress., (© 2022 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.)
Published: 2022
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38. Anti-inflammatory Effects of Ivermectin in the Treatment of Acetic Acid-Induced Colitis in Rats: Involvement of GABA B Receptors.

Author: Aryannejad A, Tabary M, Noroozi N, Mashinchi B, Iranshahi S, Tavangar SM, Mohammad Jafari R, Rashidian A, and Dehpour AR
Subjects: Acetic Acid, Animals, Baclofen pharmacology, Baclofen therapeutic use, Colon pathology, Cyclooxygenase 2, Male, NF-kappa B metabolism, Peroxidase metabolism, Rats, Rats, Wistar, Tumor Necrosis Factor-alpha metabolism, Anti-Inflammatory Agents therapeutic use, Colitis chemically induced, Colitis drug therapy, Colitis pathology, Ivermectin therapeutic use, Receptors, GABA metabolism
Abstract: Background: Recent investigations have proposed the potential role of gamma-aminobutyric acid (GABA) in regulating motility and immunity of the gastrointestinal system., Aims: We aimed to investigate the anti-inflammatory effects of ivermectin (IVM) through GABA B receptors following acetic acid-induced colitis in rats., Methods: In a controlled experimental study, we enrolled 78 male Wistar rats (13 groups; 6 rats/group). After colitis induction using acetic acid (4%), IVM, baclofen (a standard GABA B agonist) or the combination of both agents was delivered to rats orally (by gavage), with the same dosage continued for 5 days. The control group received the vehicle, and prednisolone (a standard anti-inflammatory agent) was administered in a separate group as the positive control. Colon samples were collected on the sixth day for histopathological evaluations and measurement of myeloperoxidase (MPO) activity, TNF-α levels, and p-NF-ĸB p65, COX-2 and iNOS expression levels., Results: The greatest recovery was found after administering IVM 0.5, baclofen 0.5, or IVM 0.2 + baclofen 0.2 mg/kg/day (ulcer index [UI] = 1.4 ± 0.4, 1.7 ± 0.6, and 1.4 ± 0.3, respectively; p < 0.001 vs. the control [UI = 6.5 ± 0.7]). Histopathological evaluations revealed a significant decrease in the inflammation severity in the three above-mentioned groups. P-NF-ĸB p65, COX-2, and iNOS expression, MPO activity, and TNF-α levels also decreased dramatically following treatment with IVM 0.5, baclofen 0.5, or the combination therapy (p < 0.001 vs. the control)., Conclusions: IVM exerted promising anti-inflammatory effects in treating acetic acid-induced colitis in rats. Its synergistic effect with baclofen also signified the possible involvement of GABA B receptors in this process., (© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Published: 2022
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39. The Promising Effect of Colchicine on Random-Pattern Skin Flap Survival in Rats: Glutamate Pathway.

Author: Tabary M, Aryannejad A, Noroozi N, Iranshahi S, Mohammad Jafari R, Mashinchi B, Tavangar SM, Araghi F, and Dehpour AR
Subjects: Animals, Colchicine pharmacology, Interleukin-6 metabolism, Male, Rats, Rats, Wistar, Receptors, N-Methyl-D-Aspartate, Tumor Necrosis Factor-alpha metabolism, Dizocilpine Maleate pharmacology, Glutamic Acid metabolism
Abstract: Background: Random-pattern skin flap is a conventional procedure in reconstructive surgery, yet partial or complete flap necrosis has remained a major issue. Herein, we investigated the potential effects of colchicine on skin flap survival through the glutamate pathway and N-methyl-D-aspartate (NMDA) receptors., Methods: Wistar male rats were injected multiple doses of colchicine intraperitoneally (0.02, 0.05, 0.1, and 0.4 mg/kg) before the surgery. MK-801 (a noncompetitive NMDA receptor antagonist) was administered in combination with colchicine to assess the role of glutamate. Histopathological evaluation; quantitative assessment of glutamate, IL-6, and TNF-α; and the expression of NR2A-type NMDA receptors were performed in the skin tissue., Results: Colchicine 0.05 mg/kg could significantly promote flap survival compared to the control group (P < 0.001), while administration of MK-801 (0.05 mg/kg) reversed the effect of colchicine (0.05 mg/kg) (P < 0.001). Levels of IL-6 and TNF-α decreased, and the expression of NR2A-type NMDA receptors was enhanced in the flap tissue of colchicine 0.05 mg/kg group compared to the controls. Also, glutamate level significantly increased after the administration of colchicine 0.05 mg/kg compared to the controls (P < 0.05)., Conclusions: We found that colchicine could improve skin flap survival remarkably in rats that have undergone skin flap surgery through the glutamate pathway and NMDA receptors., (Copyright © 2022 Elsevier Inc. All rights reserved.)
Published: 2022
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40. Medical management of pancreatic neuroendocrine tumors in patients with MEN 1: case report.

Author: Mohajeri-Tehrani MR, Ebrahimpur M, Nasseri-Moghaddam S, Tavangar SM, Sani MP, Zandi A, and Shadmehr MB
Abstract: Objectives: Multiple endocrine neoplasia type 1 (MEN-1) is a rare inherited autosomal dominant disease which manifests itself with at least one clinical scenario before 45 years of age. The value of somatostatin analogue therapy is unknown in the treatment of non-functioning pancreatic tumours and a few studies have been published in this field., Case Presentation: We report a young patient with MEN-1 with multiple gastric and pancreatic neuroendocrine tumors that was treated with the monthly injection of Sandostatin LAR before and After Distal Pancreatectomy and partial gastrectomy., Conclusions: Now she is well after four years of treatment with Sandostatin LAR., Competing Interests: Conflict of interestAll authors declare no financial and non-financial competing interests., (© The Author(s), under exclusive licence to Tehran University of Medical Sciences 2022.)
Published: 2022
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41. Esophagus tissue engineering: from decellularization to in vivo recellularization in two sites.

Author: Eftekharzadeh S, Akbarzadeh A, Sabetkish N, Rostami M, Zabolian AH, Hashemi J, Tavangar SM, and Kajbafzadeh AM
Subjects: Animals, Epithelial Cells, Esophagus, Extracellular Matrix, Rats, Tissue Engineering methods, Tissue Scaffolds
Abstract: To produce an esophageal scaffold with suitable features and evaluate the result of in vivo cell seeding after its implantation in the omentum and near its original anatomical position in the rat model. The esophagus of twelve rats were resected, cannulated, and decellularized via a peristaltic pump. After confirmation of decellularization and preservation of extracellular matrix, decellularized scaffolds were implanted either in the abdominal cavity (group I, n = 6) or cervical area (group II, n = 6). Histological evaluations were performed after 3 and 6 months of implantation. The results of histological evaluations, scanning electron microscopy, and the tensile test confirmed the maintenance of extracellular matrix and removal of all cellular constituents. At the time of biopsy, no evidence of inflammation was detected and the implanted scaffolds appeared normal. Histopathological evaluations of implanted tissues revealed that undifferentiated cells were seen in scaffolds of all follow-ups in both groups. Epithelial cell seeding was more advanced in biopsies of group II obtained after 6 months of operation and was accompanied by angiogenesis in surrounding adventitia. It seems that the implantation of scaffold near its original place may have an important role in further cell seeding. This method may be surpassing in comparison with traditional implantation techniques for perfecting esophageal transplantation., (© 2021. The Author(s), under exclusive licence to Springer Nature B.V.)
Published: 2022
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42. Whole-organ decellularization of the human uterus and in vivo application of the bio-scaffolds in animal models.

Author: Daryabari SS, Fendereski K, Ghorbani F, Dehnavi M, Shafikhani Y, Omranipour A, Zeraatian-Nejad Davani S, Majidi Zolbin M, Tavangar SM, and Kajbafzadeh AM
Subjects: Animals, Female, Humans, Models, Animal, Rats, Rats, Wistar, Tissue Engineering, Uterus, Extracellular Matrix metabolism, Tissue Scaffolds chemistry
Abstract: Purpose: The aim of this investigation was to design a perfusion-based decellularization protocol to provide whole human uterine bio-scaffolds with preserved structural and componential characteristics and to investigate the in vivo properties of the decellularized tissues., Methods: Eight human uteri, donated by brain-dead patients, were decellularized by perfusion of sodium dodecyl sulfate (SDS) through the uterine arteries using a peristaltic pump. The bio-scaffolds were evaluated and compared with native human uterus regarding histological, immunohistochemical, structural, and bio-mechanical properties, in addition to CT angiographies to examine the preservation of the vascular networks. Subsequently, we obtained acellular patches and implanted them on uterine defects of female Wistar rats to investigate the bio-compatibility and regenerative potential of the bio-scaffolds. Finally, we performed immunostaining to investigate the potential role of circulating stem cells in recellularization of the implanted bio-scaffolds., Results: The outcomes of this investigation confirmed the efficacy of the proposed protocol to provide whole human uterine scaffolds with characteristics and extra-cellular matrix components similar to the native human uterus. Subsequent in vivo studies demonstrated the bio-compatibility and the regenerative potential of the scaffolds and suggested a signaling pathway as an underlying mechanism for the regenerative process., Conclusions: To the best of our knowledge, this investigation provides the first efficient perfusion-based decellularization protocol for the human uterus to obtain whole-organ scaffolds. The outcomes of this investigation could be employed in future human uterus tissue engineering studies which could ultimately result in the development of novel treatments for female infertile patients., (© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Published: 2022
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43. Assessment of Sumatriptan on Sepsis-Induced Kidney injury in the Cecal Ligation and Puncture Mice Model.

Author: Yousefi-Manesh H, Shirooie S, Noori T, Tavangar SM, Sheibani M, Chaboki A, Mohammadi S, and Dehpour AR
Subjects: Animals, Cytokines, Disease Models, Animal, Kidney, Ligation, Male, Mice, Mice, Inbred C57BL, Punctures, Sepsis complications, Sepsis drug therapy, Sumatriptan pharmacology, Sumatriptan therapeutic use
Abstract: Sepsis is a severe systemic inflammatory response with high mortality rate resulting from different microorganisms. Cytokines activation is essential for the immune response, but in painful conditions like sepsis, cytokines act as a double-edged sword and dysregulate immune response which is life-threatening owing to multiple organ dysfunction. The abnormality in 5-HT function is involved in pathological conditions like irritable bowel syndrome, inflammation, myocardial ischemia, itch and renal injury. Sumatriptan, a 5-HT 1B/1D agonist, has anti-inflammatory and anti-oxidative stress effects on animal models. This study was aimed to assess the effects of sumatriptan on kidney injury, the levels of pro-inflammatory cytokines and the percentage of survival in (CLP)-induced sepsis were examined.Cecal ligation and puncture (CLP) model was done on adult C57BL/6 male mice to induce Polymicrobial sepsis. Sumatriptan was injected intraperitoneally 1 h after the sepsis induction by CLP at doses of 0.1, 0.3, and 1 mg/kg in 3 treatment groups. To study the effect of sumatriptan on short-term survival, septic animals were detected 72 h after CLP. Serum levels of TNF-α, IL-1β, IL-6 and IL-10 were evaluated. To study sepsis-induced acute renal failure, kidney functional biomarkers and histopathological alterations were evaluated.Sumatriptan (0.3 mg/kg) administration significantly enhanced survival rate (P<0.01) compared to the CLP group. The beneficial effects of sumatriptan were related to a significant decrease in the pro-inflammatory cytokines and elevated level of IL-10. Sumatriptan presented protective effects on kidney biomarkers and histopathology assay.Anti-inflammatory effects of sumatriptan lead to decrease mortality rate and inflammatory cytokines in CLP induction sepsis in C57BL/6 mice., Competing Interests: The authors declare that they have no conflict of interest., (Thieme. All rights reserved.)
Published: 2022
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44. microRNAs and long non-coding RNAs as biomarkers for polycystic ovary syndrome.

Author: Tamaddon M, Azimzadeh M, and Tavangar SM
Subjects: Biomarkers, Female, Humans, RNA, Messenger genetics, MicroRNAs genetics, Polycystic Ovary Syndrome diagnosis, Polycystic Ovary Syndrome genetics, Polycystic Ovary Syndrome metabolism, RNA, Long Noncoding genetics
Abstract: Polycystic ovary syndrome (PCOS) is known as the most common metabolic/endocrine disorder among women of reproductive age. Its complicated causality assessment and diagnostic emphasized the role of non-coding regulatory RNAs as molecular biomarkers in studying, diagnosing and even as therapeutics of PCOS. This review discusses a comparative summary of research into microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) that are molecularly or statistically related to PCOS. We categorize the literature in terms of centering on either miRNAs or lncRNAs and discuss the combinatory studies and promising ideas as well. Additionally, we compare the pros and cons of the prominent research methodologies used for each of the abovementioned research themes and discuss how errors can be stopped from propagation by selecting correct methodologies for future research. Finally, it can be concluded that research into miRNAs and lncRNAs has the potential for identifying functional networks of regulation with multiple mRNAs (and hence, functional proteins). This new understanding may eventually afford clinicians to control the molecular course of the pathogenesis better. With further research, RNA (with statistical significance and present in the blood) may be used as biomarkers for the disease, and more possibilities for RNA therapy agents can be identified., (© 2022 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.)
Published: 2022
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45. Protective effect of dapsone against bleomycin-induced lung fibrosis in rat.

Author: Yousefi-Manesh H, Noori T, Asgardoon MH, Derakhshan MH, Tavangar SM, Sheibani M, Shirooie S, and Dehpour AR
Subjects: Animals, Anti-Inflammatory Agents administration & dosage, Anti-Inflammatory Agents pharmacology, Antioxidants administration & dosage, Antioxidants pharmacology, Bleomycin toxicity, Catalase metabolism, Dapsone administration & dosage, Disease Models, Animal, Glutathione Peroxidase metabolism, Histocytochemistry, Lung cytology, Lung pathology, Oxidative Stress drug effects, Peroxidase metabolism, Rats, Rats, Wistar, Superoxide Dismutase metabolism, Bleomycin adverse effects, Dapsone pharmacology, Pulmonary Fibrosis chemically induced, Pulmonary Fibrosis drug therapy, Pulmonary Fibrosis physiopathology
Abstract: Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial disease of the lung tissue that causes symptoms such as coughing and asthma. It is caused by inflammatory factors and oxidative stress. In vivo model of IPF is induced by bleomycin (BLM,) a chemotherapeutic agent. We have investigated the effect of dapsone on bleomycin-induced IPF in adult male Wistar rats due to its anti-inflammatory and anti-oxidative stress effects. The animals were randomly divided into 5 groups (Control, BLM, BLM + dapsone 1, BLM + Dapsone 3, BLM + Dapsone 10). The control group received normal water and food. In the fibrosis group, bleomycin (BLM) (5 mg/kg) was used to induce pulmonary fibrosis by intratracheal administration. Three groups of animals were treated daily with single doses of 1, 3, and 10 mg dapsone by intraperitoneal injection 1 h after receiving BLM for 2 weeks. The activity of antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx), and oxidative stress markers such as myeloperoxidase (MPO), malondialdehyde (MDA), protein carbonyl (PC) and nitrite were measured to evaluate bleomycin and therapeutic effect of dapsone. The histological assays of lung tissues were done by Hematoxylin-eosin (H & E) and Masson's trichrome staining. BLM reduced the activity of oxidative enzymes and increased the oxidative stress markers, while treatment with dapsone has reversed the results. In addition, the total number of cells as inflammatory cells such as neutrophils and eosinophils were examined. It has been indicated BLM increased these cells, and dapsone decreased them. The results of H & E and Masson's trichrome staining showed that dapsone reduced inflammation and alveolar wall thickness and BLM-induced pulmonary fibrosis. According to the findings of this study, dapsone seems to have therapeutic effects on pulmonary fibrosis through its anti-inflammatory and anti-oxidative stress properties and reduction of the toxic effects of bleomycin., (Copyright © 2021 Elsevier Inc. All rights reserved.)
Published: 2022
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46. Utilizing the circulating tumor markers in diagnosis and management of medullary thyroid cancer.

Author: Zarkesh M, Arab N, Tavangar SM, Nozhat Z, Fanaei SM, and Hedayati M
Subjects: Humans, Prognosis, Biomarkers, Tumor blood, Carcinoma, Neuroendocrine blood, Carcinoma, Neuroendocrine diagnosis, Carcinoma, Neuroendocrine therapy, Thyroid Neoplasms blood, Thyroid Neoplasms diagnosis, Thyroid Neoplasms therapy
Abstract: Medullary thyroid cancer (MTC) is the third frequent subtype of thyroid cancer-driving from thyroid C-cells. The first-line strategy to treat MTC is surgery, but tumor recurrence and patients' mortality rate have still been demonstrated in approximately 4-10% of MTC cases. Therefore, to treat and prevent the progressive form of the disease, the early diagnosis of MTC is assumed to play a critical role. In this regard, recently, circulating biomarkers have drawn researchers' attention for their nonaggressive manners in the sample collection. In this systematic review, we aimed to focus on circulating biomarkers and their applications in MTC diagnosis, prognosis and follow-up, and we discussed their clinical application and how they can affect clinical decision making in the future. A literature search (from 2000 to 2021) was accomplished on MTC circulating biomarkers in different databases, and only English articles were evaluated. We found that calcitonin (CT) and carcinoembryonic antigen (CEA) are the most important circulating biomarkers in the MTC diagnosis. Other circulating biomarkers included pro-calcitonin (Pro-CT), pro-Gastrin releasing peptide (Pro-GRP), carbohydrate antigen 19-9 (CA 19-9) and chromogranin A (CgA). Some novel circulating biomarkers comprised vaspin and retinol-binding protein-4 (RBP4), myostatin, tumor cells (CTCs), RET M918T mutated cfDNA, circulating tumor DNA (ctDNA), miR-375 and Alu83 and Alu244 cfDNAs. Several circulating biomarkers have been identified to optimize the accuracy of diagnosis and offer new prognostic criteria, which should be verified before any clinical application. Although different circulating biomarkers contributed to MTC have been discovered, a few of them could be used in clinical diagnosis. In many cases, the application of each marker may not be useful lonely; therefore, a combination of two or more biomarkers could open a new avenue in the diagnosis, prognosis and prediction of MTC., (Copyright © 2021 Elsevier GmbH. All rights reserved.)
Published: 2022
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47. Involvement of Cannabinoid Type 2 Receptors in the Favorable Effects of Sumatriptan on the Random-Pattern Skin Flap Survival in Rats: A Novel Potential Target.

Author: Aryannejad A, Noroozi N, Tavangar SM, Ramezani S, Rashidian A, Laripour R, Yousefi Zoshk M, Dehpour AR, and Chamanara M
Subjects: Rats, Male, Animals, Rats, Wistar, Tumor Necrosis Factor-alpha metabolism, Receptors, Cannabinoid, Drug Inverse Agonism, Sumatriptan pharmacology, Cannabinoids pharmacology
Abstract: Introduction: Recent investigations have indicated the potential therapeutic role of cannabinoid type 2 (CB2) receptors in various inflammatory-related disorders. However, the role of these receptors has not been studied in skin flap models to date. In this study, we aimed to evaluate the possible involvement of CB2 receptors in the anti-inflammatory effects of sumatriptan, improving the random-pattern skin flap survival in rats., Methods: In a controlled experimental study, 36 male Wistar rats were randomly divided into 6 study groups (n = 6 per group). Two doses of sumatriptan (0.1 and 0.3 mg/kg) were administered intraperitoneally 30 min before harvesting the flap tissue. In a separate group, SR144528 (a selective CB2 receptor inverse agonist) was injected before the most effective dose of sumatriptan to determine the possible involvement of CB2 receptors in its action. Histopathological examinations, the expression level of CB2 receptors (Western blot analysis), and IL-1β and TNF-α concentrations (ELISA) were explored in the skin flap sampled tissues., Results: Sumatriptan 0.3 mg/kg remarkably enhanced the skin flap survival in all macroscopic and microscopic investigations compared to the control group (p < 0.001). IL-1β and TNF-α levels were significantly attenuated (p < 0.001), and the expression of CB2 receptors in skin cells was amplified in rats treated with sumatriptan 0.3 mg/kg (p < 0.05) compared to the control group. However, the administration of SR144528 (2 mg/kg) nullified all the protective effects of sumatriptan 0.3 mg/kg., Conclusion: We discovered that CB2 receptors play a crucial role in the favorable effects of sumatriptan on skin flap survival as a novel mechanism of action. So, targeting these receptors seems to be a dependable method in skin flap surgeries to ensure its survival and prevent tissue necrosis. Further experimental and clinical investigations are needed to ensure the safe clinical application of this method., (© 2021 S. Karger AG, Basel.)
Published: 2022
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48. Lateral flow assays (LFA) as an alternative medical diagnosis method for detection of virus species: The intertwine of nanotechnology with sensing strategies.

Author: Sadeghi P, Sohrabi H, Hejazi M, Jahanban-Esfahlan A, Baradaran B, Tohidast M, Majidi MR, Mokhtarzadeh A, Tavangar SM, and de la Guardia M
Abstract: Viruses are responsible for multiple infections in humans that impose huge health burdens on individuals and populations worldwide. Therefore, numerous diagnostic methods and strategies have been developed for prevention, management, and decreasing the burden of viral diseases, each having its advantages and limitations. Viral infections are commonly detected using serological and nucleic acid-based methods. However, these conventional and clinical approaches have some limitations that can be resolved by implementing other detector devices. Therefore, the search for sensitive, selective, portable, and costless approaches as efficient alternative clinical methods for point of care testing (POCT) analysis has gained much attention in recent years. POCT is one of the ultimate goals in virus detection, and thus, the tests need to be rapid, specific, sensitive, accessible, and user-friendly. In this review, after a brief overview of viruses and their characteristics, the conventional viral detection methods, the clinical approaches, and their advantages and shortcomings are firstly explained. Then, LFA systems working principles, benefits, classification are discussed. Furthermore, the studies regarding designing and employing LFAs in diagnosing different types of viruses, especially SARS-CoV-2 as a main concern worldwide and innovations in the LFAs' approaches and designs, are comprehensively discussed here. Furthermore, several strategies addressed in some studies for overcoming LFA limitations like low sensitivity are reviewed. Numerous techniques are adopted to increase sensitivity and perform quantitative detection. Employing several visualization methods, using different labeling reporters, integrating LFAs with other detection methods to benefit from both LFA and the integrated detection device advantages, and designing unique membranes to increase reagent reactivity, are some of the approaches that are highlighted., Competing Interests: The authors have no conflict of interest to declare., (© 2021 Elsevier B.V. All rights reserved.)
Published: 2021
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49. Comparative Effect of two Types of Surface Treatments on Shear Bond Strength of New Composite to Old Composite.

Author: Tavangar SM, Tayefeh Davalloo R, Rostamzadeh T, Darabi F, Mirabolghasemi SMA, and Ahmadi R
Abstract: Statement of the Problem: Composite restoration failures may occur because of different factors. In these situations, the repair of a composite restoration has many advantages over replacement such as saving time, lower cost, and lower risk of excessive removal of sound tooth structure and subsequent pulp exposure., Purpose: The purpose of this in vitro study was to evaluate the effects of two surface treatments on shear bond strength (SBS) of new composite to old composite., Materials and Method: In this in vitro study, 60 composite discs were fabricated using a plexiglass mold measuring 4 mm in thickness and 7 mm in diameter, and were randomly divided into three groups (n=20). In group 1, the bonding procedure was done with no modification. After roughening of one surface in all remaining samples, chloroform (CHCl3) was applied on the surface of samples in group 2 and phosphoric acid 35% was applied on the surface of the samples in group 3. PermaSeal was then applied in all samples and new composites were bonded to the surface. The samples were stored in distilled water for one week and were then subjected to 500 thermal cycles and shear bond strength between two layers of composite and mode of failures were evaluated., Results: The lowest and the highest SBS values of repair composite to old composite were noted in groups 3 and 1, respectively and this difference was statistically significant ( p < 0.05).The difference between groups 1 and 2 was not significantly different ( p = 0.197). The mode of failure was mixed in all samples of groups 2 and 3 and cohesive in group 1., Conclusion: After grinding, the surface treatment with phosphoric acid did not increase the SBS of new composite to old composite, while chloroform increased the SBS almost to the level of the baseline in control group., (Copyright: © Journal of Dentistry.)
Published: 2021
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50. Evidencing the presence of merkel cell polyomavirus in papillary thyroid cancer.

Author: Ghanghareh M, Mosayebi Amroabadi J, Tavangar SM, Irani S, Sakhaee F, Ghazanfari Jajin M, Vaziri F, Siadat SD, and Fateh A
Subjects: Adult, Case-Control Studies, Cross-Sectional Studies, DNA, Viral analysis, Female, Humans, Iran epidemiology, Male, Merkel cell polyomavirus isolation & purification, Middle Aged, Polyomavirus Infections virology, Thyroid Cancer, Papillary epidemiology, Thyroid Neoplasms epidemiology, Tumor Virus Infections virology, DNA, Viral genetics, Merkel cell polyomavirus genetics, Polyomavirus Infections complications, Thyroid Cancer, Papillary virology, Thyroid Neoplasms virology, Tumor Virus Infections complications, Viral Load
Abstract: Merkel cell polyomavirus (MCPyV) infects most people asymptomatically, but recent reports indicate that the virus may be related to carcinogenesis. This study aimed to evaluate the impact of MCPyV on the development of papillary thyroid cancer (PTC). Totally, 1057 samples, including 412 fresh biopsy samples (FBS) and 645 paraffin-embedded PTC biopsy samples (PEBS), and 1057 adjacent non-cancerous samples were assessed for the presence of MCPyV DNA and RNA. MCPyV DNA was positive in 215 (20.3%) of samples, including 126 (30.6%) in FBS and 89 (13.8%) in PEBS. In MCPyV-positive samples, the mean MCPyV copy number was higher in the patients with FBS (2.3 × 10 -1 ± 0.5 × 10 -1 copies/cell) compared to PEBS (0.7 × 10 -4 ± 0.1 × 10 -4 copies/cell) and adjacent non-PTC normal samples (0.3 × 10 -5 ± 0.02 × 10 -5 copies/cell), indicating a statistically significant difference (P < 0.001). The LT-Ag RNA expression was higher in FBS compared to PEBS, while VP1 gene transcript was not detected in any samples. Although our findings showed the presence of MCPyV in a subset of PTC Iranian patients, further research is required to confirm these findings., (© 2021. The Author(s).)
Published: 2021
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