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851 results on '"Tattersall M"'

10. Mechanisms of Treatment Failure

Author

Tattersall, M. H. N., Herfarth, Ch., editor, Senn, H.-J., editor, Baum, M., editor, Diehl, V., editor, Gutzwiller, F., editor, Rajewsky, M. F., editor, Wannenmacher, M., editor, Senn, Hans-Jörg, editor, Gelber, Richard D., editor, Goldhirsch, Aron, editor, and Thürlimann, Beat, editor

Published
1993
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17. PD-1 blockade using pembrolizumab in adolescent and young adult patients with advanced bone and soft tissue sarcoma

Author

Scheinberg, T, Lomax, A, Tattersall, M, Thomas, D, McCowage, G, Sullivan, M, Karim, R, Luk, PP, Mahar, A, Bonar, F, Bhadri, VA, Scheinberg, T, Lomax, A, Tattersall, M, Thomas, D, McCowage, G, Sullivan, M, Karim, R, Luk, PP, Mahar, A, Bonar, F, and Bhadri, VA

Abstract

BACKGROUND: Sarcomas represent 10%-15% of cancers in adolescent and young adult (AYA) patients, and survival for those with metastatic disease or relapse is poor. Immunotherapy with checkpoint inhibition has improved outcomes in multiple tumor types, but data in advanced sarcomas, particularly within the AYA population, are limited. AIM: We aim to evaluate response and toxicity for AYA patients with sarcoma treated with pembrolizumab. METHODS AND RESULTS: We retrospectively reviewed AYA patients with advanced bone and soft tissue sarcoma who received self-funded pembrolizumab between May 2015 and January 2019. Eighteen patients were identified. One patient with Ewing sarcoma had a sustained complete response to therapy. Two patients with alveolar soft part sarcoma received a clinical benefit from pembrolizumab: one had a radiological partial response with an excellent clinical response and one patient achieved stable disease. Four patients died of disease prior to first scheduled assessment and thus were not evaluable. The remaining eleven patients had progressive disease. CONCLUSION: The role of immunotherapy in AYA sarcoma warrants further investigation. Biomarkers of response need to be further evaluated in order to guide patient selection.

Published
2021

27. Summary

Author

Tattersall, M. H. N., Herfarth, Ch., editor, Senn, H. J., editor, Baum, M., editor, Diehl, V., editor, Gutzwiller, F., editor, Rajewsky, M. F., editor, Wannenmacher, M., editor, Senn, Hans Jörg, editor, Gelber, Richard D., editor, Goldhirsch, Aron, editor, and Thürlimann, Beat, editor

Published
1996
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43. Estimating survival in advanced cancer: a comparison of estimates made by oncologists and patients

Author

Smith-Uffen, M. E. S., primary, Johnson, S. B., additional, Martin, A. J., additional, Tattersall, M. H. N., additional, Stockler, M. R., additional, Bell, M. L., additional, Detering, K., additional, Clayton, J. M., additional, Silvester, W., additional, Clarke, S., additional, Vaccaro, L., additional, Beale, P., additional, and Kiely, B. E., additional

Published
2019
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45. Development and Pilot Testing of a Decision Aid for Genomic Research Participants Notified of Clinically Actionable Research Findings for Cancer Risk

Author

Willis, AM, Smith, SK, Meiser, B, Ballinger, ML, Thomas, DM, Tattersall, M, Young, MA, Willis, AM, Smith, SK, Meiser, B, Ballinger, ML, Thomas, DM, Tattersall, M, and Young, MA

Abstract

Germline genomic testing is increasingly used in research to identify genetic causes of disease, including cancer. However, there is evidence that individuals who are notified of clinically actionable research findings have difficulty making informed decisions regarding uptake of genetic counseling for these findings. This study aimed to produce and pilot test a decision aid to assist participants in genomic research studies who are notified of clinically actionable research findings to make informed choices regarding uptake of genetic counseling. Development was guided by published literature, the International Patient Decision Aid Standards, and the expertise of a steering committee of clinicians, researchers, and consumers. Decision aid acceptability was assessed by self-report questionnaire. All 19 participants stated that the decision aid was easy to read, clearly presented, increased their understanding of the implications of taking up research findings, and would be helpful in decision-making. While low to moderate levels of distress/worry were reported after reading the booklet, a majority of participants also reported feeling reassured. All participants would recommend the booklet to others considering uptake of clinically actionable research findings. Results indicate the decision aid is acceptable to the target audience, with potential as a useful decision support tool for genomic research participants.

Published
2018

46. Effect of systemic adjuvant treatment on first sites of breast cancer relapse

Author

Goldhirsch, Aron, Gelber, Richard D, Price, Karen N, Castiglione, Monica, Coates, Alan S, Rudenstam, Carl-Magnus, Collins, John, Lindtner, Jurij, Hacking, Anne, Marini, Giovanni, Byrne, Michael, Cortes-Funes, Hernan, Schnurch, Georg, Brunner, Kurt W, Tattersall, M H N, Forbes, John, and Senn, Hans-Jorg

Published
1994

47. P1.04-11 Exploring the Germ-Line Contribution to Exceptional Response to PD-1/PD-L1 Inhibition in Patients with NSCLC by Whole Genome Sequencing

Author

Barnet, M., primary, Jackson, K., additional, Gao, B., additional, Nagrial, A., additional, Boyer, M., additional, Cooper, W., additional, Hui, R., additional, Linton, A., additional, Tattersall, M., additional, Russell, A., additional, Gibson, G., additional, Cebon, J., additional, Long, G., additional, Menzies, A., additional, Scolyer, R., additional, Lacaze, P., additional, Brink, R., additional, Peters, T., additional, Cowley, M., additional, Gayevskiy, V., additional, Thomas, D., additional, Pinese, M., additional, Blinman, P., additional, Kao, S., additional, and Goodnow, C., additional

Published
2018
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48. Parosteal osteosarcoma of mandible

Author

Noroozi, L., primary, McCarthy, S., additional, Karim, R., additional, Bonar, F., additional, Clark, J., additional, Tattersall, M., additional, Gupta, R., additional, Mahar, A., additional, and Jackett, L., additional

Published
2018
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