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368 results on '"Tatsuguchi, Atsushi"'

10. Novel Method of Sampling the Gastrointestinal Muscle Layer: Feasibility of Endoscopic Muscular Resection with a Ligation Device in an in Vivo Porcine Model

Author

Osamu, Goto, Kazutoshi, Higuchi, Atsushi, Tatsuguchi, Eriko, Koizumi, Hiroto, Noda, Takeshi, Onda, Jun, Omori, Mitsuru, Kaise, Katsuhiko, Iwakiri, Goto, Osamu, Higuchi, Kazutoshi, Tatsuguchi, Atsushi, Koizumi, Eriko, Noda, Hiroto, Onda, Takeshi, Omori, Jun, Kaise, Mitsuru, Iwakiri, Katsuhiko, Osamu, Goto, Kazutoshi, Higuchi, Atsushi, Tatsuguchi, Eriko, Koizumi, Hiroto, Noda, Takeshi, Onda, Jun, Omori, Mitsuru, Kaise, Katsuhiko, Iwakiri, Goto, Osamu, Higuchi, Kazutoshi, Tatsuguchi, Atsushi, Koizumi, Eriko, Noda, Hiroto, Onda, Takeshi, Omori, Jun, Kaise, Mitsuru, and Iwakiri, Katsuhiko

Abstract

source:https://www.nms.ac.jp/sh/jnms/2021/088050441.pdf

Published
2022

12. Additional file 1 of Genetic analysis of Japanese patients with small bowel adenocarcinoma using next-generation sequencing

Author

Tatsuguchi, Atsushi, Yamada, Takeshi, Ueda, Koji, Furuki, Hiroyasu, Hoshimoto, Aitoshi, Nishimoto, Takayoshi, Omori, Jun, Akimoto, Naohiko, Gudis, Katya, Tanaka, Shu, Fujimori, Shunji, Shimizu, Akira, and Iwakiri, Katsuhiko

Subjects
congenital, hereditary, and neonatal diseases and abnormalities, complex mixtures, digestive system diseases
Abstract

Additional file 1. Relationship between MMR status and clinicopathological factors of patients with SBA.

Published
2022
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17. Novel Method of Sampling the Gastrointestinal Muscle Layer: Feasibility of Endoscopic Muscular Resection with a Ligation Device in an in Vivo Porcine Model

Author

Osamu, Goto, Kazutoshi, Higuchi, Atsushi, Tatsuguchi, Eriko, Koizumi, Hiroto, Noda, Takeshi, Onda, Jun, Omori, Mitsuru, Kaise, Katsuhiko, Iwakiri, Goto, Osamu, Higuchi, Kazutoshi, Tatsuguchi, Atsushi, Koizumi, Eriko, Noda, Hiroto, Onda, Takeshi, Omori, Jun, Kaise, Mitsuru, and Iwakiri, Katsuhiko

Subjects
Muscle tissue, medicine.medical_specialty, business.product_category, Gastrointestinal Diseases, Swine, Biopsy, In vivo, medicine, Animals, Esophagus, Survival rate, Ligation, business.industry, Stomach, Muscles, Histology, Endoscopy, Muscle, Smooth, General Medicine, Surgery, medicine.anatomical_structure, Rubber band, Feasibility Studies, business
Abstract

BACKGROUND Gastrointestinal muscular sampling is useful in the histological assessment of functional gastrointestinal disorders. We devised a new sampling method to obtain a large volume of muscle tissues and then investigated the feasibility and safety of endoscopic muscular resection with a ligation device in an in vivo porcine model. METHODS After establishing a submucosal tunnel, a rubber band was placed on the muscle tissue by sucking the exposed muscle layer. Thereafter, the established pseudopolyp was removed using an electrocautery snare, and the entry site of the submucosal tunnel was closed endoscopically. This procedure was performed at three sites in the esophagus and stomach of two pigs. The technical success, histology, and survival rate on postoperative day 7 were examined postoperatively. RESULTS We successfully completed the mentioned procedure in 11 of the 12 sites (92%), without the occurrence of severe adverse events. The median diameters of obtained tissues from the esophagus and stomach, respectively, were 5 mm and 10 mm. Histologically, both the inner and outer muscle layers were included in all specimens. The postprocedural course was found uneventful in both pigs during the observatory period. CONCLUSIONS Endoscopic muscular resection using a ligation device enabled us to obtain large and thick muscle tissue samples. This approach may facilitate more precise histological assessments of functional gastrointestinal disorders.

Published
2021

21. Additional file 1 of Three-dimensional visualization improves the endoscopic diagnosis of superficial gastric neoplasia

Author

Higuchi, Kazutoshi, Kaise, Mitsuru, Noda, Hiroto, Kirita, Kumiko, Koizumi, Eriko, Umeda, Takamitsu, Akimoto, Teppei, Omori, Jun, Akimoto, Naohiko, Goto, Osamu, Tatsuguchi, Atsushi, and Iwakiri, Katsuhiko

Abstract

Additional file 1: Supplementary Table 1. The comparison of the coincidence rate of lesion extent in group A and group B. Supplementary Table 2. The comparison of the ease of endoscopic lesion recognition by the skill level of endoscopists.

Published
2021
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30. Heregulin-[alpha] and heregulin-[beta] expression is linked to a COX-2-[PGE.sub.2] pathway in human gastric fibroblasts

Author

Nagata, Kazuhiro, Wada, Ken, Tatsuguchi, Atsushi, Futagami, Seije, Gudis, Katya, Miyake, Kazumasa, Tsukui, Taku, and Sakamoto, Choitsu

Subjects
COX-2 inhibitors -- Research, Cyclooxygenases -- Research, Biological sciences
Abstract

We have previously shown heregulin (HRG)-[alpha] expression in human gastric fibroblasts and its stimulation of gastric epithelial cell growth. Although cyclooxygenase (COX)-2 has also been shown to stimulate growth factor production in these cells, the interaction between COX-2 and HRG remains unknown. Conditioned media (CM) from gastric fibroblasts incubated with [PGE.sub.2] or interleukin (IL)-1[beta], a well known COX-2 inducer, were analyzed for their effect on erbB3 tyrosine phosphorylation in MKN28 gastric epithelial cells. HRG protein expression in fibroblast lysates and CM was also examined by western blot. HRG-[alpha] and HRG-[beta] mRNA expression in gastric fibroblasts and human gastric tissue was examined by real-time quantitative PCR. HRG and COX-2 expressions in surgical resections of human gastric ulcer tissue were examined immunohistochemically. CM from fibroblasts incubated with [PGE.sub.2], or IL-1[beta], stimulated erbB3 phosphorylation in MKN28 cells. Preincubation of the fibroblasts with celecoxib, a selective COX-2 inhibitor, suppressed CM-induced erbB3 phosphorylation. This inhibition was reversed by exogenous [PGE.sub.2]. As with erbB3 phophorylation, IL-1[beta] stimulated both HRG-[alpha] and HRG-[beta] mRNA expression, as well as HRG release into gastric fibroblast CM. IL-1[beta]-stimulated HRG expression and release were also inhibited by celecoxib, and exogenous [PGE.sub.2] restored this inhibitory effect, suggesting the activation of an IL-1[beta]-COX-2-[PGE.sub.2] pathway that culminates in the release of HRG from fibroblasts. HRG-[alpha] and HRG-[beta] mRNA levels were significantly higher in gastriculcer tissue than in normal gastric mucosa. HRG immunoreactivity was found in interstitial cells of the gastric ulcer bed and coexpressed with COX-2. These results suggest that HRG might be a new member of the growth factor family involved in the COX-2-dependent ulcer repair process. cyclooxygenase-2

Published
2006

31. Clinicopathologic characteristics and A20 mutation in primary thyroid lymphoma

Author

Kuribayashi-Hamada, Yasuko, primary, Ishibashi, Mariko, additional, Tatsuguchi, Atsushi, additional, Asayama, Toshio, additional, Takada-Okuyama, Namiko, additional, Onodera-Kondo, Asaka, additional, Moriya, Keiichi, additional, Igarashi, Takehito, additional, Onose, Hiroyuki, additional, Tanosaki, Sakae, additional, Yokose, Norio, additional, Yamaguchi, Hiroki, additional, and Tamura, Hideto, additional

Published
2021
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33. A case of immune-related adverse effect (irAE) colitis Induced by the Long-term Use of pembrolizumab in a Patient with Small Cell Lung Cancer

Author

Minowa, Masumi, primary, Onda, Takeshi, additional, Hamakubo, Ryouhei, additional, Koeda, Mai, additional, Yoshida, Yuji, additional, Okubo, Tomomi, additional, Nishimoto, Takayoshi, additional, Itokawa, Norio, additional, Tatsuguchi, Atsushi, additional, Fujimori, Syunji, additional, Hatori, Tsutomu, additional, and Iwakiri, Katsuhiko, additional

Published
2020
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34. Induced microsomal PGE synthase-1 is involved in cyclooxygenase-2-dependent PGE2 production in gastric fibroblasts

Author

Shinji, Yoko, Tsukui, Taku, Tatsuguchi, Atsushi, Shinoki, Kei, Kusunoki, Masafumi, Suzuki, Kenji, Hiratsuka, Tetsuro, Wada, Ken, Futagami, Seiji, Miyake, Kazumasa, Gudis, Katya, and Sakamoto, Choitsu

Subjects
COX-2 inhibitors -- Research, Fibroblasts -- Research, Biological sciences
Abstract

We have previously shown that the cyclooxygenase (COX)-2/PGE2 pathway plays a key role in VEGF production in gastric fibroblasts. Recent studies have identified three PGE synthase (PGES) isozymes: cytosolic PGES (cPGES) and microsomal PGES (mPGES)-1 and -2, but little is known regarding the expression and roles of these enzymes in gastric fibroblasts. Thus we examined IL-1[beta]-stimulated mPGES-1 and cPGES mRNA and protein expression in gastric fibroblasts by quantitative PCR and Western blot analysis, respectively, and studied both their relationship to COX-1 and -2 and their roles in PGE2 and VEGF production in vitro. IL-1[beta] stimulated increases in both COX-2 and mPGES-1 mRNA and protein expression levels. However, COX-2 mRNA and protein expression were more rapidly induced than mPGES-1 mRNA and protein expression. Furthermore, MK-886, a nonselective mPGES-1 inhibitor, failed to inhibit IL-1[beta]-induced PGE2 release at the 8-h time point, while totally inhibiting PGE2 at the later stage. However, MK-886 did inhibit IL-1[beta]-stimulated PGES activity in vitro by 86.8%. N-(2-cyclohexyloxy-4-nitrophenyl) -methanesulfonamide (NS-398), a selective COX-2 inhibitor, totally inhibited PGE2 production at both the 8-h and 24-h time points, suggesting that COX-2-dependent PGE2 generation does not depend on mPGES-1 activity at the early stage. In contrast, NS-398 did not inhibit VEGF production at 8 h, and only partially at 24 h, whereas MK-886 totally inhibited VEGF production at each time point. These results suggest that IL-1[beta]-induced mPGES-1 protein expression preferentially coupled with COX-2 protein at late stages of PGE2 production and that IL-1[beta]-stimulated VEGF production was totally dependent on membrane-associated proteins involved in eicosanoid and glutathione metabolism (MAPEG) superfamily proteins, which includes mPGES-1, but was partially dependent on the COX-2/PGE2 pathway. interleukin-1[beta]; MK-886; MAPEG superfamily; prostaglandin E synthase activity

Published
2005

35. Cyclooxygenase-2-regulated vascular endothelial growth factor release in gastric fibroblasts

Author

Miura, Shuhei, Tatsuguchi, Atsushi, Wada, Ken, Takeyama, Hiroki, Shinji, Yoko, Hiratsuka, Tetsuro, Futagami, Seiji, Miyake, Kazumasa, Gudis, Katya, Mizokami, Yuji, Matsuoka, Takeshi, and Sakamoto, Choitsu

Subjects
Prostaglandins -- Research, Biological sciences
Abstract

VEGF is a highly specific stimulator of endothelial cells and may play an important role in angiogenesis in the process of tissue regeneration. We previously showed that cyclooxygenase-2 (COX-2) expressed in mesenchymal cells of the ulcer bed is involved in the ulcer repair process. To clarify the role of COX-2 in angiogenesis during gastric ulcer healing, we investigated the relation between COX-2 expression and VEGF production in human gastric fibroblasts in vivo and in vitro. Gastric fibroblasts were cultured in RPMI 1640 with and without IL-1[alpha] or IL-1[beta] in the presence or absence of NS-398, a selective COX-2 inhibitor. Supernatant VEGF and PG[E.sub.2] concentrations were measured by enzyme-linked immunosorbent assay. COX-2 expression in fibroblasts was determined by Western blot analysis. VEGF and COX-2 expression in surgical resections of human gastric ulcer tissue was examined immunohistochemically. IL-1 dose dependently enhanced VEGF release in cultured gastric fibroblasts after a 24-h stimulation. IL-1 also stimulated PG[E.sub.2] production in gastric fibroblasts via COX-2 induction. NS-398 significantly suppressed VEGF and PG[E.sub.2] release from IL-1-stimulated gastric fibroblasts; concurrent addition of PG[E.sub.2] restored NS-398-inhibited VEGF release. COX-2 and VEGF immunoreactivity were colocalized in fibroblast-like ceils in the ulcer bed of gastric tissues. These results suggest that COX-2 plays a key role in VEGF production in gastric fibroblasts stimulated by IL-1 in vitro and that anglogenesis induced by the COX-2-VEGF pathway might be involved in gastric ulcer healing. prostaglandin [E.sub.2]; gastric ulcer; angiogenesis; repair process

Published
2004

37. Three-dimensional flexible endoscopy enables more accurate endoscopic recognition and endoscopic submucosal dissection marking for superficial gastric neoplasia: a pilot study to compare two- and three-dimensional imaging

Author

Higuchi, Kazutoshi, primary, Kaise, Mitsuru, additional, Noda, Hiroto, additional, Kirita, Kumiko, additional, Koizumi, Eriko, additional, Umeda, Takamitsu, additional, Akimoto, Teppei, additional, Omori, Jun, additional, Akimoto, Naohiko, additional, Goto, Osamu, additional, Tatsuguchi, Atsushi, additional, and Iwakiri, Katsuhiko, additional

Published
2020
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40. Su1175 CLINICAL SIGNIFICANCE OF PROGRAMMED DEATH-LIGAND 1 AND 2 EXPRESSION IN SMALL BOWEL ADENOCARCINOMA: CORRELATION WITH MISMATCH REPAIR DEFICIENCY

Author

Hoshimoto, Aitoshi, primary, Tatsuguchi, Atsushi, additional, Yamada, Takeshi, additional, Nishimoto, Takayoshi, additional, Akimoto, Naohiko, additional, Mitsui, Keigo, additional, Tanaka, Shu, additional, Gudis, Katya, additional, Fujimori, Shunji, additional, and Iwakiri, Katsuhiko, additional

Published
2020
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