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107 results on '"Tatic, Svetislav"'

2. Comprehensive Investigation of Angiogenesis, PASS Score and Immunohistochemical Factors in Risk Assessment of Malignancy for Paraganglioma and Pheochromocytoma.

Author

Milinkovic, Marija, Soldatovic, Ivan, Zivaljevic, Vladan, Bozic, Vesna, Zivotic, Maja, Tatic, Svetislav, and Dundjerovic, Dusko

Subjects
ADRENAL tumors, PARAGANGLIOMA, SERTOLI cells, PHEOCHROMOCYTOMA, RISK assessment, SUCCINATE dehydrogenase, NEOVASCULARIZATION
Abstract

A challenging task in routine practice is finding the distinction between benign and malignant paragangliomas and pheochromocytomas. The aim of this study is to conduct a comparative analysis of angiogenesis by assessing intratumoral microvascular density (MVD) with immunohistochemical (IHC) markers (CD31, CD34, CD105, ERG), and S100 immunoreactivity, Ki67 proliferative index, succinate dehydrogenase B (SDHB) expressiveness, tumor size with one the most utilized score Pheochromocytoma of Adrenal Gland Scales Score (PASS), using tissue microarray (TMA) with 115 tumor samples, 61 benign (PASS < 4) and 54 potentially malignant (PASS ≥ 4). We found no notable difference between intratumoral MVD and potentially malignant behavior. The group of potentially malignant tumors is significantly larger in size, has lower intratumoral MVD, and a decreased number of S100 labeled sustentacular cells. Both groups have low proliferative activity (mean Ki67 is 1.02 and 1.22, respectively). Most tumors maintain SDHB expression, only 6 cases (5.2%) showed a loss of expression (4 of them in PASS < 4 group and 2 in PASS ≥ 4). PASS score is easily available for assessment and complemented with markers of biological behavior to complete the risk stratification algorithm. Size is directly related to PASS score and malignancy. Intratumoral MVD is extensively developed but it is not crucial in evaluating the malignant potential. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Redox metabolism correlates with cellular turnover and clinical phenotype of papillary thyroid carcinoma and colloid goiter.

Author

Rovcanin, Branislav, Gopcevic, Kristina, Kekic, Dusan, Zivaljevic, Vladan, Diklic, Aleksandar, Tatic, Svetislav, Jovanovic, Milan, Odalovic, Bozidar, and Paunovic, Ivan

Subjects
MUCINOUS adenocarcinoma, PAPILLARY carcinoma, THYROID cancer, GOITER, OXIDATION-reduction reaction, BRAF genes, LYMPHATIC metastasis
Abstract

Introduction: Papillary thyroid carcinoma (PTC) and colloid goiter (CG) represent the most common thyroid malignant and benign diseases, respectively. Oxidative stress is considered to have an important role in the pathogenesis of both diseases, but without sufficient and comprehensive data. The aim was to evaluate the redox profile, its influence on cell survival of PTC, comparing it with CG as a control and its relation with demographic, pathological and clinical parameters.Material and methods: We evaluated for the first time the PTC and CG tissue profile of advanced oxidation protein products (AOPP) and total thiols as parameters of redox metabolism and deoxyribonuclease I (DNase I) and deoxyribonuclease II (DNase II) activity as biomarkers of cell turnover and apoptosis. Tissue levels of biochemical parameters were quantified in PTC and CG tissue using spectrophotometric methods. Study parameters were evaluated in light of different demographic, clinical and pathological features of PTC and CG.Results: Papillary thyroid carcinoma tissue is characterized by increased antioxidant activity and a normal prooxidation level. Biochemical parameters show numerous correlations with demographic and clinical characteristics of PTC and CG patients. DNase I and II activities are dependent upon the AOPP concentration in PTC tissue. The size of CG can be predicted with combined use of AOPP, DNase I and DNase II. AOPP is the most powerful predictor of PTC capsular invasion, multicentric intrathyroid dissemination and lymph node metastasis phenotype.Conclusions: Evaluated parameters can be used for assessment of tumor redox and survival status and the clinical course of PTC and CG. [ABSTRACT FROM AUTHOR]

Published
2022
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15. Intracerebral hemorrhage as a first sign of pheochromocytoma: case report and review of the literature

Author

Pekic, Sandra, primary, Jovanovic, Vladimir, additional, Tasic, Goran, additional, Paunovic, Ivan, additional, Tatic, Svetislav, additional, Dundjerovic, Dusko, additional, Doknic, Mirjana, additional, Miljic, Dragana, additional, Stojanovic, Marko, additional, Nikolic Djurovic, Marina, additional, Petakov, Milan, additional, and Popovic, Vera, additional

Published
2019
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17. Pitfalls in diagnosing a small cystic insulinoma: a case report

Author

Sumarac-Dumanovic Mirjana, Micic Dragan, Krstic Miodrag, Georgiev Maja, Diklic Aleksandar, Tatic Svetislav, Stamenkovic-Pejkovic Danica, Kendereski Aleksandra, Cvijovic Goran, and Pavlovic Aleksandra

Subjects
Medicine
Abstract

Abstract Insulinoma is a rare pancreatic endocrine tumour and is typically sporadic and solitary. Over 90% of all insulinomas are benign. Cystic insulinomas are also rare. It is not difficult to determine the site of such neoplasm, as cystic insulinomas are usually 4–10 cm in diameter. We present the case of a patient with a histologically confirmed cystic insulinoma diagnosed after approximately 10 years of hypoglycaemia symptoms. This case is unique because of the small size (2.2 cm) of the tumour. Endoscopic ultrasound (EUS) was useful for localizing this tumour.

Published
2007
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19. Intracerebral hemorrhage as a first sign of pheochromocytoma

Author

Djurdjevic, Sandra Pekic, primary, Jovanovic, Vladimir, additional, Tasic, Goran, additional, Paunovic, Ivan, additional, Tatic, Svetislav, additional, Dundjerovic, Dusko, additional, Doknic, Mirjana, additional, Miljic, Dragana, additional, Stojanovic, Marko, additional, Jemuovic, Zvezdana, additional, Djurovic, Marina Nikolic, additional, Popovic, Vera, additional, and Petakov, Milan, additional

Published
2018
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21. Concomitant high expression of survivin and vascular endothelial growth factor-C is strongly associated with metastatic status of lymph nodes in papillary thyroid carcinoma.

Author

Selemetjev, Sonja, Savin, Svetlana, Paunovic, Ivan, Tatic, Svetislav, and Cvejic, Dubravka

Subjects
SURVIVIN (Protein), VASCULAR endothelial growth factors, LYMPH nodes, METASTASIS, THYROID cancer
Abstract

Purpose: Papillary thyroid carcinoma (PTC) has a strong propensity to metastasize to regional lymph nodes which increases the risk of local-regional relapse and affects the course of the disease. Molecular pathogenesis of lymph node metastasis (LNM) is not yet fully understood. Survivin, a multifunctionale molecule involved in apoptosis, proliferation and angiogenesis, and vascular endothelial growth factor-C (VEGF-C) are suggested to be implicated in lymphatic metastases of human malignancies.Materials and Methods: Expression of survivin and VEGF-C was examined by immunohistochemistry and Western blot in 75 cases of PTCs in relation to their LNM status. Additionally, survivin and VEGF-C were immunohistochemically analyzed in 15 primary PTCs paired with their metastatic tissue in lymph nodes.Results: High expression of survivin and VEGF-C was found in 62.7% and 64.0% cases, respectively, with a positive correlation to each other (Spearman's correlation co-efficient = 0.878, P < 0.001). Expression levels of both proteins were significantly higher in patients with LNM than in those without LNM (P < 0.001). The rate of concomitant high expression of survivin and VEGF-C in patients with LNM involvement was 88.9% (P < 0.01). Metastatic tissue in lymph nodes expressed survivin and VEGF-C at the same high extent as their primary tumors.Conclusion: Concomitant high expression of survivin and VEGF-C is closely associated with LNM status of PTC patients, which suggests their cooperation in the metastatic process. Evaluation of survivin and VEGF-C expression could be clinically significant in predicting the metastatic potential of PTC and subsequent treatment and follow-up of these patients. [ABSTRACT FROM AUTHOR]

Published
2018
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24. Coexpressed High Levels of VEGF-C and Active MMP-9 Are Associated With Lymphatic Spreading and Local Invasiveness of Papillary Thyroid Carcinoma.

Author

Šelemetjev, Sonja, Đorić, Ilona, Paunović, Ivan, Tatić, Svetislav, Cvejić, Dubravka, Ðoric, Ilona, Paunovic, Ivan, Tatic, Svetislav, and Cvejic, Dubravka

Subjects
PAPILLARY carcinoma, VASCULAR endothelial growth factors, MATRIX metalloproteinases
Abstract

Objectives: Papillary thyroid carcinoma (PTC) usually has a good prognosis, but some patients develop an aggressive course of the disease, leading to a poor outcome. Vascular endothelial growth factor C (VEGF-C) and matrix metalloproteinase 9 (MMP-9) have been shown to play roles in tumor progression in various human malignancies.Methods: We analyzed VEGF-C and active MMP-9 expression profiles in PTC samples using immunohistochemistry and Western blotting.Results: Immunohistochemistry showed positive staining for VEGF-C and active MMP-9 in 83% and 57% of PTCs, respectively (n = 60), with a positive correlation between their expression levels (Spearman, P < .001). Concomitant high expression of VEGF-C and active MMP-9 correlated with the presence of lymph node metastasis (P  = .005), pT status (P  = .004), pTNM tumor stage (P  = .005), and particularly the degree of tumor infiltration (P < .001, Fisher exact test). Densitometric analysis of Western blot bands confirmed correlation between VEGF-C and active MMP-9 expression (Wilcoxon and Spearman tests) and significant association with the clinicopathologic parameters (Mann-Whitney and Kruskal-Wallis tests).Conclusions: Association of coexpressed high levels of VEGF-C and active MMP-9 with lymphatic spreading and local invasiveness of PTC suggests their potential usefulness as predictive biomarkers of aggressive PTC behavior. [ABSTRACT FROM AUTHOR]

Published
2016
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25. The impact of PTEN tumor suppressor gene on acquiring resistance to tamoxifen treatment in breast cancer patients

Author

Tanić, Nikola, Milovanović, Zorka M., Tanić, Nasta, Dzodic, Radan, Juranic, Zorica, Šušnjar, Snežana, Plesinac-Karapandzic, Vesna, Tatic, Svetislav, Dramićanin, Tatjana, Davidović, Radoslav S., Dimitrijević, Bogomir B., Tanić, Nikola, Milovanović, Zorka M., Tanić, Nasta, Dzodic, Radan, Juranic, Zorica, Šušnjar, Snežana, Plesinac-Karapandzic, Vesna, Tatic, Svetislav, Dramićanin, Tatjana, Davidović, Radoslav S., and Dimitrijević, Bogomir B.

Abstract

Tamoxifen is a standard therapeutical treatment in patients with estrogen receptor positive breast carcinoma. However, less than 50% of estrogen receptor positive breast cancers do not respond to tamoxifen treatment whereas 40% of tumors that initially respond to treatment develop resistance over time. The underlying mechanisms for tamoxifen resistance are probably multifactorial but remain largely unknown. The primary aim of this study was to investigate the impact of PTEN tumor suppressor gene on acquiring resistance to tamoxifen by analyzing loss of heterozygosity (LOH) and immunohystochemical expression of PTEN in 49 primary breast carcinomas of patients treated with tamoxifen as the only adjuvant therapy. The effect of PTEN inactivation on breast cancer progression and disease outcome was also analyzed. Reduced or completely lost PTEN expression was observed in 55.1% of samples, while 63.3% of samples displayed LOH of PTEN gene. Inactivation of PTEN immunoexpression significantly correlated with the PTEN loss of heterozygosity, suggesting LOH as the most important genetic mechanism for the reduction or complete loss of PTEN expression in primary breast carcinoma. Most importantly, LOH of PTEN and consequential reduction of its immunoexpression showed significant correlation with the recurrence of the disease. Besides, our study revealed that LOH of PTEN tumor suppressor was significantly associated with shorter disease free survival, breast cancer specific survival and overall survival. In summary, our results imply that LOH of PTEN could be used as a good prognostic characteristic for the outcome of breast cancer patients treated with tamoxifen.

Published
2012

27. The impact of PTEN tumor suppressor gene on acquiring resistance to tamoxifen treatment in breast cancer patients

Author

Tanic, Nikola, primary, Milovanovic, Zorka, additional, Tanic, Nasta, additional, Dzodic, Radan, additional, Juranic, Zorica, additional, Susnjar, Snezana, additional, Plesinac-Karapandzic, Vesna, additional, Tatic, Svetislav, additional, Dramicanin, Tatjana, additional, Davidovic, Radoslav, additional, and Dimitrijevic, Bogomir, additional

Published
2012
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28. What’s in the Image Pituitary Metastasis from Papillary Carcinoma of the Thyroid: A Case Report and a Comprehensive Review of the Literature

Author

Stojanovic, Marko, primary, Pekic, Sandra, additional, Doknic, Mirjana, additional, Miljic, Dragana, additional, Ciric, Slavica, additional, Diklic, Aleksandar, additional, Tatic, Svetislav, additional, Joksimovic, Miloje, additional, Manojlovic-Gacic, Emilija, additional, Skender-Gazibara, Milica, additional, and Popovic, Vera, additional

Published
2012
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31. Primary carcinoid of the ovary

Author

Djurovic, Marina, primary, Damjanovic, Svetozar, additional, Tatic, Svetislav, additional, Micev, Marjan, additional, Cetkovic, Aleksandar, additional, Petakov, Milan, additional, Djukic, Vladimir, additional, Miljic, Dragana, additional, Pekic, Sandra, additional, Doknic, Mirjana, additional, Stojanovic, Marko, additional, Vuksanovic, Aleksandar, additional, and Popovic, Vera, additional

Published
2011
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37. Ectopic corticotroph syndrome

Author

Penezic, Zorana, primary, Savic, Slavica, additional, Vujovic, Svetlana, additional, Tatic, Svetislav, additional, Ercegovac, Maja, additional, and Drezgic, Milka, additional

Published
2004
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41. Ptimary thyroid lymphomas and other rare thyroid tumors

Author

Diklic, Aleksandar, primary, Zivaljevic, Vladan, additional, Paunovic, Ivan, additional, Krgovic, Ksenija, additional, Zivic, Rastko, additional, Kazic, Milena, additional, Kalezic, Nevena, additional, Tatic, Svetislav, additional, Havelka, Marija, additional, and Bozic, Vesna, additional

Published
2003
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42. Surgical management of recurrent thyroid cancer

Author

Diklic, Aleksandar, primary, Zivaljevic, Vladan, additional, Paunovic, Ivan, additional, Krgovic, Ksenija, additional, Zivic, Rastko, additional, Kazic, Milena, additional, Kalezic, Nevena, additional, Tatic, Svetislav, additional, Havelka, Marija, additional, and Bozic, Vesna, additional

Published
2003
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43. Follicular thyroid carcinoma

Author

Krgovic, Ksenija, primary, Paunovic, Ivan, additional, Diklic, Aleksandar, additional, Zivaljevic, Vladan, additional, Tatic, Svetislav, additional, Havelka, Marija, additional, Todorovic-Kazic, Milena, additional, Kalezic, Nevena, additional, and Bozic, Vesna, additional

Published
2003
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44. Medullary thyroid carcinoma: Sporadic, hereditary

Author

Paunovic, Ivan, primary, Diklic, Aleksandar, additional, Krgovic, Ksenija, additional, Zivaljevic, Vladan, additional, Tatic, Svetislav, additional, Havelka, Marija, additional, Kalezic, Nevena, additional, Todorovic-Kazic, Milena, additional, and Bozic, Vesna, additional

Published
2003
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48. Cytological evaluation of thyroid solitary nodules

Author

Tatic, Svetislav, primary, Havelka, Marija, additional, Sopta, Jelena, additional, Bozic, Vesna, additional, Paunovic, Ivan, additional, Diklic, Aleksandar, additional, Krgovic, Ksenija, additional, Zivaljevic, Vladan, additional, Todorovic, Milena, additional, and Kalezic, Nevena, additional

Published
2003
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49. Rational diagnosis and surgical management of thyroid nodule

Author

Paunovic, Ivan, primary, Diklic, Aleksandar, additional, Krgovic, Ksenija, additional, Zivaljevic, Vladan, additional, Tatic, Svetislav, additional, Havelka, Marija, additional, Kalezic, Nevena, additional, Todorovic-Kazic, Milena, additional, and Bozic, Vesna, additional

Published
2003
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