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76 results on '"Tataranno, M. L."'

2. Quantification of stress exposure in very preterm infants: Development of the NeO-stress score

Author

Brain, Child Health, MS Neonatologie, Meesters, N. J., van den Bosch, G. E., van het Hof, L. J., Benders, M. J.N.L., Tataranno, M. L., Reiss, I. K.M., van Kaam, A., Haverman, L., Simons, S. H.P., van Dijk, M., Brain, Child Health, MS Neonatologie, Meesters, N. J., van den Bosch, G. E., van het Hof, L. J., Benders, M. J.N.L., Tataranno, M. L., Reiss, I. K.M., van Kaam, A., Haverman, L., Simons, S. H.P., and van Dijk, M.

Published
2023

3. Introduction of ultra-high-field MR brain imaging in infants: vital parameters, temperature and comfort

Author

MS Neonatologie, Arts-assistenten Kinderen, Brain, Child Health, Developmental Disorders, Circulatory Health, Regenerative Medicine and Stem Cells, MS Radiologie, Highfield Research Group, Cancer, Beeldverwerking ISI, Computational Imaging, Infection & Immunity, van Ooijen, I. M., Annink, K. V., Benders, M. J.N.L., Dudink, J., Alderliesten, T., Groenendaal, F., Tataranno, M. L., Lequin, M. H., Hoogduin, J. M., Visser, F., Raaijmakers, A. J.E., Klomp, D. W.J., Wiegers, E. C., Wijnen, J. P., van der Aa, N. E., MS Neonatologie, Arts-assistenten Kinderen, Brain, Child Health, Developmental Disorders, Circulatory Health, Regenerative Medicine and Stem Cells, MS Radiologie, Highfield Research Group, Cancer, Beeldverwerking ISI, Computational Imaging, Infection & Immunity, van Ooijen, I. M., Annink, K. V., Benders, M. J.N.L., Dudink, J., Alderliesten, T., Groenendaal, F., Tataranno, M. L., Lequin, M. H., Hoogduin, J. M., Visser, F., Raaijmakers, A. J.E., Klomp, D. W.J., Wiegers, E. C., Wijnen, J. P., and van der Aa, N. E.

Published
2023

4. Creating an optimal observational sleep stage classification system for very and extremely preterm infants

Author

Cardiovasculaire Epi Team 5, MS Neonatologie, Child Health, Brain, Infection & Immunity, Developmental Disorders, de Groot, E R, Bik, A, Sam, C, Wang, X, Shellhaas, R A, Austin, T, Tataranno, M L, Benders, M J N L, van den Hoogen, A, Dudink, J, Cardiovasculaire Epi Team 5, MS Neonatologie, Child Health, Brain, Infection & Immunity, Developmental Disorders, de Groot, E R, Bik, A, Sam, C, Wang, X, Shellhaas, R A, Austin, T, Tataranno, M L, Benders, M J N L, van den Hoogen, A, and Dudink, J

Published
2022

5. Shape variability of the central sulcus in the developing brain: a longitudinal descriptive and predictive study in preterm infants

Author

Kinderbewegingszorg patientenzorg, MS Neonatologie, Child Health, Brain, de Vareilles, H, Rivière, D, Sun, Z, Fischer, C, Leroy, F, Neumane, S, Stopar, N, Eijsermans, R, Ballu, M, Tataranno, M L, Benders, Mjnl, Mangin, J F, Dubois, J, Kinderbewegingszorg patientenzorg, MS Neonatologie, Child Health, Brain, de Vareilles, H, Rivière, D, Sun, Z, Fischer, C, Leroy, F, Neumane, S, Stopar, N, Eijsermans, R, Ballu, M, Tataranno, M L, Benders, Mjnl, Mangin, J F, and Dubois, J

Published
2022

6. Management of oxygen saturation monitoring in preterm newborns in the NICU: the Italian picture

Author

Perrone S., Giordano M., De Bernardo G., Lugani P., Sarnacchiaro P., Stazzoni G., Buonocore G., Esposito S., Tataranno M. L., Pesce S., Grappone L., Riccitelli M., Cornacchione S., De Virgilio N., Laschi E., Perrone, S., Giordano, M., De Bernardo, G., Lugani, P., Sarnacchiaro, P., Stazzoni, G., Buonocore, G., Esposito, S., Tataranno, M. L., Pesce, S., Grappone, L., Riccitelli, M., Cornacchione, S., De Virgilio, N., and Laschi, E.

Subjects
Male, NICU, medicine.medical_specialty, Operating procedures, Oxygen saturation, Population, Pediatrics, RJ1-570, 03 medical and health sciences, 0302 clinical medicine, Neonate, 030225 pediatrics, Intensive Care Units, Neonatal, Surveys and Questionnaires, Health care, medicine, Surveys and Questionnaire, Humans, 030212 general & internal medicine, Neonatology, Oximetry, education, Oxygen saturation (medicine), Cross-Sectional Studie, education.field_of_study, Data collection, Health professionals, business.industry, Research, Infant, Newborn, Oxygen monitoring, Cross-Sectional Studies, Italy, Emergency medicine, Female, business, Infant, Premature, Human
Abstract

Background Although many studies emphasize the importance of using oxygen saturation (SpO2) targets in the NICUs, there is a wide variability in used saturation ranges among centers. Primary aim was to draw a representative picture on how the management of oxygen monitoring is performed in the Italian NICUs. Second aim was to identify healthcare-professionals related factors associated with oxygen targeting in the preterm population. Methods Cross-sectional study with data collection via an electronic survey form. A questionnaire containing pre-piloted and open questions on monitoring and management of the SpO2 was administered to neonatologists across the network of the Italian Society of Neonatology. The questions focused on: the infrastructure, specific training, healthcare professionals and patients-related factors. The results of the survey were anonymously collected, summarized and analyzed. Results Out of 378 questionnaires, 93 were correctly filled. Thirty-six different SpO2 ranges were observed. Centers using written standard operating procedures on oxygen management and SpO2 monitoring maintained a correct average range of SpO2 90–95%, avoided hyperoxia and reconsidered saturation targets in relation to comorbidities. 39.8% of responders disabled alarms during neonatal care. One center used biomarkers for complete monitoring of neonatal oxygenation status. Conclusions There is considerable variation in SpO2 targets for preterm infants in the Italian NICUs. Standard operating procedures and specific training for health care personnel are the main factors playing a role for the correct maintenance of the recommended oxygen targets in preterms.

Published
2020

8. Relationship Between Early Functional and Structural Brain Developments and Brain Injury in Preterm Infants

Author

MS Neonatologie, Brain, Child Health, MS CGO, Cancer, De Wel, O, Van Huffel, S, Lavanga, M, Jansen, K, Dereymaeker, A, Dudink, J, Gui, L, Hüppi, P S, de Vries, L S, Naulaers, G, Benders, M J N L, Tataranno, M L, MS Neonatologie, Brain, Child Health, MS CGO, Cancer, De Wel, O, Van Huffel, S, Lavanga, M, Jansen, K, Dereymaeker, A, Dudink, J, Gui, L, Hüppi, P S, de Vries, L S, Naulaers, G, Benders, M J N L, and Tataranno, M L

Published
2021

9. Morphine affects brain activity and volumes in preterms : An observational multi-center study

Author

Tataranno, M. L., Gui, L., Hellström-Westas, Lena, Toet, M., Groenendaal, F., Claessens, N. H. P., Schuurmans, J., Fellman, V, Savman, K., de Vries, L. S., Huppi, P., Benders, M. J. N. L., Tataranno, M. L., Gui, L., Hellström-Westas, Lena, Toet, M., Groenendaal, F., Claessens, N. H. P., Schuurmans, J., Fellman, V, Savman, K., de Vries, L. S., Huppi, P., and Benders, M. J. N. L.

Abstract

Objective: We hypothesized that morphine has a depressing effect on early brain activity, assessed using quantitative aEEG/EEG parameter and depressed activity will be associated with brain volumes at term in extremely preterm infants. Study design: 174 preterm infants were enrolled in 3 European tertiary NICUs (mean GA:26 +/- 1wks) and monitored during the first 72 h after birth with continuous 2 channel aEEG. Six epochs of aEEG recordings were selected and minimum amplitude of aEEG (min aEEG), percentage of time amplitude< 5 mu V (% of time < 5 mu V), spontaneous activity transients (SATrate) and interSAT interval (ISI) were calculated. For infants receiving morphine, the cumulative morphine dosage was calculated. In a subgroup of 58 infants, good quality MRI at term equivalent age (TEA) and the cumulative morphine dose until TEA were available. The effects of morphine administration and cumulative dose on aEEG/EEG measures and on brain volumes were investigated. Results: Morphine administration had a significant effect on all quantitative aEEG/EEG measures, causing depression of early brain activity [longer ISI (beta 2.900), reduced SAT rate (beta -1.386), decreased min aEEG (beta -0.782), and increased % of time < 5 mu V (beta 14.802)] in all epochs. A significant effect of GA and postnatal age on aEEG/EEG measures was observed. Cumulative morphine dose until TEA had a significant negative effect on total brain volume (TBV) (beta -8.066) and cerebellar volume (beta -1.080). Conclusions: Administration of sedative drugs should be considered when interpreting aEEG/EEG together with the negative dose dependent morphine impact on brain development.

Published
2020
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10. Morphine affects brain activity and volumes in preterms : An observational multi-center study

Author

Tataranno, M L, Gui, L, Hellström-Westas, L, Toet, M, Groenendaal, F, Claessens, N H P, Schuurmans, J, Fellman, V, Sävman, K, de Vries, L S, Huppi, P, Benders, M J N L, Tataranno, M L, Gui, L, Hellström-Westas, L, Toet, M, Groenendaal, F, Claessens, N H P, Schuurmans, J, Fellman, V, Sävman, K, de Vries, L S, Huppi, P, and Benders, M J N L

Published
2020

11. Morphine affects brain activity and volumes in preterms: An observational multi-center study

Author

MS Neonatologie, Other research (not in main researchprogram), Brain, Child Health, Regenerative Medicine and Stem Cells, Arts-assistenten Kinderen, Tataranno, M L, Gui, L, Hellström-Westas, L, Toet, M, Groenendaal, F, Claessens, N H P, Schuurmans, J, Fellman, V, Sävman, K, de Vries, L S, Huppi, P, Benders, M J N L, MS Neonatologie, Other research (not in main researchprogram), Brain, Child Health, Regenerative Medicine and Stem Cells, Arts-assistenten Kinderen, Tataranno, M L, Gui, L, Hellström-Westas, L, Toet, M, Groenendaal, F, Claessens, N H P, Schuurmans, J, Fellman, V, Sävman, K, de Vries, L S, Huppi, P, and Benders, M J N L

Published
2020

12. Predictive Role of F2-Isoprostanes as Biomarkers for Brain Damage after Neonatal Surgery

Author

Stolwijk, L. J., Lemmers, P. M. A., Van, Herwaarden, M. Y. A., van der Zee, D. C., van Bel, F., Groenendaal, F., Tataranno, M. L., Calderisi, Marco, Longini, Mariangela, Bazzini, Francesco, Benders, M. J. N. L., and Buonocore, Giuseppe

Subjects
Male, Clinical Biochemistry, medicine.disease_cause, Gastroenterology, Postoperative Complications, Neonate, 0302 clinical medicine, 030202 anesthesiology, Prospective cohort study, F2-Isoprostanes, lcsh:R5-920, Brain, Gestational age, General Medicine, Thoracotomy, Anesthesia, Cohort, Biomarker (medicine), Female, medicine.symptom, lcsh:Medicine (General), Research Article, medicine.medical_specialty, Article Subject, Iron, Brain damage, Anesthesia, General, 03 medical and health sciences, 030225 pediatrics, Internal medicine, Journal Article, Genetics, medicine, Humans, Molecular Biology, Laparotomy, business.industry, Biochemistry (medical), Infant, Newborn, Case-control study, Biomarker, Perioperative, Oxidative Stress, Brain Injuries, Case-Control Studies, Surgery, business, Biomarkers, Oxidative stress
Abstract

Objective. Neonates have a high risk of oxidative stress during anesthetic procedures. The predictive role of oxidative stress biomarkers on the occurrence of brain injury in the perioperative period has not been reported before. Methods. A prospective cohort study of patients requiring major surgery in the neonatal period was conducted. Biomarker levels of nonprotein-bound iron (NPBI) in plasma and F2-isoprostane in plasma and urine before and after surgical intervention were determined. Brain injury was assessed using postoperative MRI. Results. In total, 61 neonates were included, median gestational age at 39 weeks (range 31–42) and weight at 3000 grams (1400–4400). Mild to moderate brain lesions were found in 66%. Logistic regression analysis showed a significant difference between plasma NPBI in patients with nonparenchymal injury versus no brain injury: 1.34 umol/L was identified as correlation threshold for nonparenchymal injury (sensitivity 67%, specificity 91%). In the multivariable analysis, correcting for GA, no other significant relation was found with the oxidative stress biomarkers and risk factors. Conclusion. Oxidative stress seems to occur during anaesthesia in this cohort of neonates. Plasma nonprotein-bound iron showed to be associated with nonparenchymal injury after surgery, with values of 1.34 umol/L or higher. Risk factors should be elucidated in a more homogeneous patient group.

Published
2017
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13. Predictive Role of F2-Isoprostanes as Biomarkers for Brain Damage after Neonatal Surgery

Author

Stolwijk, L J, Lemmers, P M A, van Herwaarden, M Y A, van der Zee, D C, van Bel, F, Groenendaal, F, Tataranno, M L, Calderisi, M, Longini, M., Bazzini, F, Benders, M J N L, Buonocore, G., Stolwijk, L J, Lemmers, P M A, van Herwaarden, M Y A, van der Zee, D C, van Bel, F, Groenendaal, F, Tataranno, M L, Calderisi, M, Longini, M., Bazzini, F, Benders, M J N L, and Buonocore, G.

Published
2017

14. Predictive Role of F2-Isoprostanes as Biomarkers for Brain Damage after Neonatal Surgery

Author

Brain, MS Neonatologie, Child Health, Regenerative Medicine and Stem Cells, Zorgeenheid Kinderchirurgie Medisch, Other research (not in main researchprogram), Stolwijk, L J, Lemmers, P M A, van Herwaarden, M Y A, van der Zee, D C, van Bel, F, Groenendaal, F, Tataranno, M L, Calderisi, M, Longini, M., Bazzini, F, Benders, M J N L, Buonocore, G., Brain, MS Neonatologie, Child Health, Regenerative Medicine and Stem Cells, Zorgeenheid Kinderchirurgie Medisch, Other research (not in main researchprogram), Stolwijk, L J, Lemmers, P M A, van Herwaarden, M Y A, van der Zee, D C, van Bel, F, Groenendaal, F, Tataranno, M L, Calderisi, M, Longini, M., Bazzini, F, Benders, M J N L, and Buonocore, G.

Published
2017

15. Oxidative Stress as a Physiological Pain Response in Full-Term Newborns

Author

Perrone, S., primary, Bellieni, C. V., additional, Negro, S., additional, Longini, M., additional, Santacroce, A., additional, Tataranno, M. L., additional, Bazzini, F., additional, Belvisi, E., additional, Picardi, A., additional, Proietti, F., additional, Iantorno, L., additional, and Buonocore, G., additional

Published
2017
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47. Maternal obesity and perinatal oxidative stress: The strength of the association

Author

Negro, S., Boutsikou, T., Briana, D. D., Tataranno, M. L., Longini, M., Proietti, F., Bazzini, F., Dani, C., Malamitsi-Puchner, A., Giuseppe Buonocore, and Perrone, S.

Subjects
Adult, Male, Intrauterine growth restriction, Gestational Age, Body Mass Index, Maternal obesity, Pregnancy, Risk Factors, F2 isoprostanes, Newborn infant, Oxidative stress, Medicine (all), Birth Weight, Humans, Obesity, Prospective Studies, F2-Isoprostanes, Infant, Newborn, Infant, Fetal Blood, Oxidative Stress, Perinatal Care, Infant, Small for Gestational Age, Multivariate Analysis, Female, Lipid Peroxidation
Abstract

Maternal obesity is a chronic inflammatory state, which has been shown to induce increased levels of free fatty acids, reactive oxygen species and inflammatory cells. Recent evidence reveals increased levels of lipid peroxidation products in the plasma of obese women during pregnancy. The aim of this study was to test the hypothesis that maternal overweight or obesity is associated with increased oxidative stress (OS) in offspring. Two hundred and forty-five pregnant women and their newborns were prospectively enrolled. Mothers were divided in two groups: lean control - LC (n=175, Group I); overweight or obese (n=70, Group II) according to BMI ≥ 25 before pregnancy. Cord blood F2-isoprostanes (F2-IsoPs), as reliable markers of OS, were measured in all newborns. Lower 1 minute APGAR score and higher weight at discharge were found in Group II neonates, compared to those of Group I (p less than 0.05). Small for gestational age (SGA) newborns of both groups showed increased levels of F2-IsoPs than appropriate (AGA) or large (LGA) for gestational age (GA) (p less than 0.01). SGA newborns of Group II had higher F2-IsoPs levels compared to SGA of Group I (p less than 0.01), which were significantly correlated to maternal BMI at the end of pregnancy (r=0.451, p less than 0.01). Multivariate regression analysis corrected for confounding factors, showed that maternal overweight or obesity was significantly associated with high F2-IsoPs levels in SGA offspring (p less than 0.01). Maternal overweight or obesity is associated with increased OS in their SGA newborns. Data suggest the need of antioxidant protection for both mothers during pregnancy and infants soon after birth.

48. Predictive Role of F2-Isoprostanes as Biomarkers for Brain Damage after Neonatal Surgery.

Author

Stolwijk, L. J., Lemmers, P. M. A., van Herwaarden, M. Y. A., van der Zee, D. C., van Bel, F., Groenendaal, F., Tataranno, M. L., Calderisi, M., Longini, M., Bazzini, F., Benders, M. J. N. L., and Buonocore, G.

Subjects
*OXIDATIVE stress, *DIAGNOSIS of brain damage, *BIOMARKERS, *NEONATAL surgery, *ISOPROSTANES, RISK factors
Abstract

Objective. Neonates have a high risk of oxidative stress during anesthetic procedures. The predictive role of oxidative stress biomarkers on the occurrence of brain injury in the perioperative period has not been reported before. Methods. A prospective cohort study of patients requiring major surgery in the neonatal period was conducted. Biomarker levels of nonprotein-bound iron (NPBI) in plasma and F2-isoprostane in plasma and urine before and after surgical intervention were determined. Brain injury was assessed using postoperative MRI. Results. In total, 61 neonates were included, median gestational age at 39 weeks (range 31–42) and weight at 3000 grams (1400–4400). Mild to moderate brain lesions were found in 66%. Logistic regression analysis showed a significant difference between plasma NPBI in patients with nonparenchymal injury versus no brain injury: 1.34 umol/L was identified as correlation threshold for nonparenchymal injury (sensitivity 67%, specificity 91%). In the multivariable analysis, correcting for GA, no other significant relation was found with the oxidative stress biomarkers and risk factors. Conclusion. Oxidative stress seems to occur during anaesthesia in this cohort of neonates. Plasma nonprotein-bound iron showed to be associated with nonparenchymal injury after surgery, with values of 1.34 umol/L or higher. Risk factors should be elucidated in a more homogeneous patient group. [ABSTRACT FROM AUTHOR]

Published
2017
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49. Introduction of ultra-high-field MR brain imaging in infants: vital parameters, temperature and comfort.

Author

van Ooijen IM, Annink KV, Benders MJNL, Dudink J, Alderliesten T, Groenendaal F, Tataranno ML, Lequin MH, Hoogduin JM, Visser F, Raaijmakers AJE, Klomp DWJ, Wiegers EC, Wijnen JP, and van der Aa NE

Abstract

Background: Brain MRI in infants at ultra-high-field scanners might improve diagnostic quality, but safety should be evaluated first. In our previous study, we reported simulated specific absorption rates and acoustic noise data at 7 Tesla., Methods: In this study, we included twenty infants between term-equivalent age and three months of age. The infants were scanned on a 7 Tesla MRI directly after their clinically indicated 3 Tesla brain MRI scan. Vital parameters, temperature, and comfort were monitored throughout the process. Brain temperature was estimated during the MRI scans using proton MR spectroscopy., Results: We found no significant differences in vital parameters, temperature, and comfort during and after 7 Tesla MRI scans, compared to 3 Tesla MRI scans., Conclusions: These data confirm our hypothesis that scanning infants at 7 Tesla MRI appears to be safe and we identified no additional risks from scanning at 3 Tesla MRI., Competing Interests: The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: F. Visser has a partial employment with a commercial organization (Philips Healthcare, Best, The Netherlands) and F. Groenendaal is an expert witness in medicolegal cases. The other authors report no disclosures., (© 2023 University Medical Centre Utrecht.)

Published
2023
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50. Quantification of stress exposure in very preterm infants: Development of the NeO-stress score.

Author

Meesters NJ, van den Bosch GE, van Het Hof LJ, Benders MJNL, Tataranno ML, Reiss IKM, van Kaam A, Haverman L, Simons SHP, and van Dijk M

Subjects
Infant, Infant, Newborn, Humans, Intensive Care Units, Neonatal, Child Development, Stress, Psychological epidemiology, Infant, Premature physiology, Infant, Very Low Birth Weight
Abstract

Background: Stress during treatment at the Neonatal Intensive Care Unit (NICU) has long-term negative consequences on preterm infants' development., Aims: We developed an instrument suited to validly determine the cumulative stress exposure for preterm infants in a NICU., Study Design: This survey study made use of two consecutive questionnaires., Subjects: NICU nurses and physicians from the nine NICUs in the Netherlands., Outcome Measures: First, respondents rated the relevance of 77 items encompassing potentially stressful procedures, commented on their comprehensibility and the comprehensiveness of the list. We calculated the content validity per item (CVI-I) and included only the relevant items in a second questionnaire in which the participants rated the stressfulness from 0 (not stressful) to 10 (extremely stressful). A stressfulness index - representing the median score - was calculated for each included item., Results: Based on the CVI-I of the 77 items, step 1 resulted in 38 items considered relevant to quantify stress in preterm infants during the first 28 days of life. This list of 38 items exists of 34 items with a CVI-I if 0.78 or higher, one of these items was split into two items, and three items were added to improve comprehensiveness. The stressfulness index ranged from five to nine., Conclusions: The NeO-stress score consists of stressful items including their severity index and was developed to determine cumulative stress exposure of preterm infants. Evaluating the cross-cultural validity, correlating it to behavioural and biological stress responses, and evaluating its ability to predict preterm infants at risk for the negative effects following stress might expand the possibilities for this instrument., Competing Interests: Conflict of interest None declared., (Copyright © 2022. Published by Elsevier B.V.)

Published
2023
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