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31 results on '"Tassi Yunga, Samuel"'

9. Additional file 6 of Characterization of the primary antibody response to Plasmodium falciparum antigens in infants living in a malaria-endemic area

Author

Tassi Yunga, Samuel, Siriwardhana, Chathura, Fouda, Genevieve G., Bobbili, Naveen, Sama, Grace, Chen, John J., Leke, Rose F. G., and Taylor, Diane Wallace

Abstract

Additional file 6: Figure S6. No correlation between Ab levels at birth and number of infections detected by microscopy. Antibody levels (MFI) at the first visit (mean 9 ± 2 days) were plotted against the number of times each baby was slide-positive during the first year of life. No association between high Ab levels at birth and number of slide-positive infections was found.

Published
2022
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10. Additional file 5 of Characterization of the primary antibody response to Plasmodium falciparum antigens in infants living in a malaria-endemic area

Author

Tassi Yunga, Samuel, Siriwardhana, Chathura, Fouda, Genevieve G., Bobbili, Naveen, Sama, Grace, Chen, John J., Leke, Rose F. G., and Taylor, Diane Wallace

Abstract

Additional file 5: Figure S5. No correlation between Ab levels at birth and number of infections detected by PCR. Antibody levels (MFI) for each baby at the first visit (mean 9 ± 2 days) were plotted against the number of times the baby was PCR-positive during the first year of life. No association between Ab levels at birth and number of PCR-detected infections was seen.

Published
2022
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11. Additional file 1 of Characterization of the primary antibody response to Plasmodium falciparum antigens in infants living in a malaria-endemic area

Author

Tassi Yunga, Samuel, Siriwardhana, Chathura, Fouda, Genevieve G., Bobbili, Naveen, Sama, Grace, Chen, John J., Leke, Rose F. G., and Taylor, Diane Wallace

Abstract

Additional file 1: Figure S1. Comparison of antibody levels in babies at 1 week of life whose subsequent primary infections were sub-microscopic (n = 18) or detected by slide-microscopy (n = 39) Horizontal lines = medians. SUB = sub-microscopic infection; Slide = infection detected by microscopy.

Published
2022
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12. Additional file 3 of Characterization of the primary antibody response to Plasmodium falciparum antigens in infants living in a malaria-endemic area

Author

Tassi Yunga, Samuel, Siriwardhana, Chathura, Fouda, Genevieve G., Bobbili, Naveen, Sama, Grace, Chen, John J., Leke, Rose F. G., and Taylor, Diane Wallace

Abstract

Additional file 3: Figure S3. Some infants had several IgG responses during the first year of life Note: MFI were similar between the primary and secondary IgG Ab response. Figure A-H show IgG responses of different infants (Baby#). Babies A-E had only 1 to 2 detected infections; whereas, babies F to H had multiple infections.

Published
2022
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13. Additional file 2 of Characterization of the primary antibody response to Plasmodium falciparum antigens in infants living in a malaria-endemic area

Author

Tassi Yunga, Samuel, Siriwardhana, Chathura, Fouda, Genevieve G., Bobbili, Naveen, Sama, Grace, Chen, John J., Leke, Rose F. G., and Taylor, Diane Wallace

Abstract

Additional file 2: Figure S2. IgM antibody levels during the first year of life. Horizontal lines show the cut-off for antibody positivity. (n = 47 babies). A. AMA-1 (3D7), B. AMA1 (FVO); C. EBA-175; D. MSP2 (3D7); E. MSA2 (FC27) F. MSP1-42 (3D7); G. MSP1-42 (FVO); H. MSP3; I. RESA, J. LSA1, and K. CSP.

Published
2022
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14. Additional file 4 of Characterization of the primary antibody response to Plasmodium falciparum antigens in infants living in a malaria-endemic area

Author

Tassi Yunga, Samuel, Siriwardhana, Chathura, Fouda, Genevieve G., Bobbili, Naveen, Sama, Grace, Chen, John J., Leke, Rose F. G., and Taylor, Diane Wallace

Abstract

Additional file 4: Figsure S4. No correlation between antibody levels at birth and time to first infection. Ab levels (MFI) in plasma collected at the first visit (mean 9 ± 2 days) of each baby were plotted against time (days) to first infection that was detected by PCR or slide. Simple linear regression was used to determine if Ab levels to any of the antigens was associated with a significant delay in time to infection. No association was found (all R2 values were very low < 0.01 indicating no association) and all p values were non-significant (> 0.01), showing the regression lines did not differ significant from zero (horizontal). Babies who remained malaria-negative during the first year were assigned a value of 366 days as the time to first infection.

Published
2022
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18. Effects of ex vivoblood anticoagulation and preanalytical processing time on the proteome content of platelets

Author

Tassi Yunga, Samuel, Gower, Austin J., Melrose, Alexander R., Fitzgerald, Meghan K., Rajendran, Ashmitha, Lusardi, Theresa A., Armstrong, Randall J., Minnier, Jessica, Jordan, Kelley R., McCarty, Owen J.T., David, Larry L., Wilmarth, Phillip A., Reddy, Ashok P., and Aslan, Joseph E.

Abstract

Ex vivoassays of platelet function critically inform mechanistic and clinical hematology studies, where effects of divergent blood processing methods on platelet composition are apparent, but unspecified.

Published
2022
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19. Identification, Quantification, and System Analysis of Protein N‐ε Lysine Methylation in Anucleate Blood Platelets

Author

Rocheleau, Anne D., primary, Melrose, Alexander R., additional, Cunliffe, Jennifer M., additional, Klimek, John, additional, Babur, Özgün, additional, Tassi Yunga, Samuel, additional, Ngo, Anh T. P., additional, Pang, Jiaqing, additional, David, Larry L., additional, McCarty, Owen J. T., additional, and Aslan, Joseph E., additional

Published
2019
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20. The role of coagulation and platelets in colon cancer-associated thrombosis

Author

Mitrugno, Annachiara, primary, Tassi Yunga, Samuel, additional, Sylman, Joanna L., additional, Zilberman-Rudenko, Jevgenia, additional, Shirai, Toshiaki, additional, Hebert, Jessica F., additional, Kayton, Robert, additional, Zhang, Ying, additional, Nan, Xiaolin, additional, Shatzel, Joseph J., additional, Esener, Sadik, additional, Duvernay, Matthew T., additional, Hamm, Heidi E., additional, Gruber, András, additional, Williams, Craig D., additional, Takata, Yumie, additional, Armstrong, Randall, additional, Morgan, Terry K., additional, and McCarty, Owen J. T., additional

Published
2019
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24. Detection of Plasmodium falciparum DNA in saliva samples stored at room temperature: potential for a non-invasive saliva-based diagnostic test for malaria

Author

Mfuh, Kenji O., primary, Tassi Yunga, Samuel, additional, Esemu, Livo F., additional, Bekindaka, Obase Ngemani, additional, Yonga, Jessica, additional, Djontu, Jean Claude, additional, Mbakop, Calixt D., additional, Taylor, Diane W., additional, Nerurkar, Vivek R., additional, and Leke, Rose G. F., additional

Published
2017
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27. Carpe low-dose aspirin: the new anti-cancer face of an old anti-platelet drug.

Author

Mitrugno, Annachiara, Sylman, Joanna L., Rigg, Rachel A., Tassi Yunga, Samuel, Shatzel, Joseph J., Williams, Craig D., and McCarty, Owen J.T.

Subjects
ASPIRIN, NONSTEROIDAL anti-inflammatory agents, CANCER invasiveness, METASTASIS, TUMORS
Abstract

Cancer metastasis is a dynamic process during which cancer cells separate from a primary tumor, migrate through the vessel wall into the bloodstream, and extravasate at distant sites to form secondary colonies. During this process, circulating tumor cells are subjected to shear stress forces from blood flow, and in contact with plasma proteins and blood cells of the immune and hemostatic system, including platelets. Many studies have shown an association between high platelet count and cancer metastasis, suggesting that platelets may play an occult role in tumorigenesis. This mini-review summarizes recent and emerging discoveries of mechanisms by which cancer cells activate platelets and the role of activated platelets in promoting tumor growth and metastasis. Moreover, the review discusses how aspirin has the potential for being clinically used as an adjuvant in cancer therapy. [ABSTRACT FROM AUTHOR]

Published
2018
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28. PCR-based detection of Plasmodium falciparumin saliva using mitochondrial cox3and varATSprimers

Author

Lloyd, Yukie, Esemu, Livo, Antallan, Jovikka, Thomas, Bradley, Tassi Yunga, Samuel, Obase, Bekindaka, Christine, Nana, Leke, Rose, Culleton, Richard, Mfuh, Kenji, Nerurkar, Vivek, and Taylor, Diane

Abstract

Sampling of saliva for diagnosing Plasmodium falciparuminfections is a safe, non-invasive alternative to sampling of blood. However, the use of saliva presents a challenge because lower concentrations of parasite DNA are present in saliva compared to peripheral blood. Therefore, a sensitive method is needed for detection of parasite DNA in saliva. This study utilized two recently reported “ultra-sensitive” PCR assays based on detection of the P. falciparummitochondrial cox3gene and the multi-copy nuclear varATSgene. The ultra-sensitive assays have an advantage over standard 18S rRNA gene-based PCR assay as they target genes with higher copy numbers per parasite genome. Stored saliva DNA samples from 60 Cameroonian individuals with infections previously confirmed by 18S rRNA gene PCR in peripheral blood were tested with assays targeting the cox3and varATSgenes. Overall, the standard 18S rRNA gene-based PCR assay detected P. falciparumDNA in 62% of the stored saliva DNA samples, whereas 77 and 68% of the samples were positive with assays that target the cox3and varATSgenes, respectively. Interestingly, the ultra-sensitive assays detected more P. falciparuminfections in stored saliva samples than were originally detected by thick-film microscopy (41/60 = 68%). When stratified by number of parasites in the blood, the cox3assay successfully detected more than 90% of infections using saliva when individuals had > 1000 parasites/μl of peripheral blood, but sensitivity was reduced at submicroscopic parasitemia levels. Bands on electrophoresis gels were distinct for the cox3assay, whereas faint or non-specific bands were sometimes observed for varATSand 18S rRNA that made interpretation of results difficult. Assays could be completed in 3.5 and 3 h for the cox3and varATSassays, respectively, whereas the 18S rRNA gene assays required at least 7 h. This study demonstrates that a PCR assay targeting the cox3gene detected P. falciparumDNA in more saliva samples than primers for the 18S rRNA gene. Non-invasive collection of saliva in combination with the proposed cox3primer-based PCR assay could potentially enhance routine testing of P. falciparumduring disease surveillance, monitoring, and evaluation of interventions for malaria elimination.

Published
2018
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29. Does Antibody Avidity to Plasmodium falciparumMerozoite Antigens Increase with Age in Individuals Living in Malaria-Endemic Areas?

Author

Tassi Yunga, Samuel, Bobbili, Naveen, Lloyd, Yukie M., Antallan, Jovikka, Matsunaga, Masako, Quakyi, Isabella, Leke, Rose F. G., and Taylor, Diane Wallace

Abstract

High-avidity antibodies (Abs) are acquired after a few Plasmodium falciparuminfections in low transmission areas, but it remains unclear if Ab avidity to different merozoite antigens increases with age in individuals with persistent antigenemia and, if so, when a fully mature Ab response occurs. The study used plasma samples collected between 1996 and 1998 from 566 individuals aged 4 to 84?years in Simbok, Cameroon, where residents received an estimated 1.6 infectious mosquito bites/person/night.

Published
2021
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31. The role of coagulation and platelets in colon cancer-associated thrombosis.

Author

Mitrugno A, Tassi Yunga S, Sylman JL, Zilberman-Rudenko J, Shirai T, Hebert JF, Kayton R, Zhang Y, Nan X, Shatzel JJ, Esener S, Duvernay MT, Hamm HE, Gruber A, Williams CD, Takata Y, Armstrong R, Morgan TK, and McCarty OJT

Subjects
Blood Platelets pathology, Cell Line, Tumor, Colonic Neoplasms pathology, Cross-Sectional Studies, Humans, Retrospective Studies, Thrombosis pathology, Blood Coagulation physiology, Blood Platelets physiology, Colonic Neoplasms blood, Thrombosis blood
Abstract

Cancer-associated thrombosis is a common first presenting sign of malignancy and is currently the second leading cause of death in cancer patients after their malignancy. However, the molecular mechanisms underlying cancer-associated thrombosis remain undefined. In this study, we aimed to develop a better understanding of how cancer cells affect the coagulation cascade and platelet activation to induce a prothrombotic phenotype. Our results show that colon cancer cells trigger platelet activation in a manner dependent on cancer cell tissue factor (TF) expression, thrombin generation, activation of the protease-activated receptor 4 (PAR4) on platelets and consequent release of ADP and thromboxane A2. Platelet-colon cancer cell interactions potentiated the release of platelet-derived extracellular vesicles (EVs) rather than cancer cell-derived EVs. Our data show that single colon cancer cells were capable of recruiting and activating platelets and generating fibrin in plasma under shear flow. Finally, in a retrospective analysis of colon cancer patients, we found that the number of venous thromboembolism events was 4.5 times higher in colon cancer patients than in a control population. In conclusion, our data suggest that platelet-cancer cell interactions and perhaps platelet procoagulant EVs may contribute to the prothrombotic phenotype of colon cancer patients. Our work may provide rationale for targeting platelet-cancer cell interactions with PAR4 antagonists together with aspirin and/or ADP receptor antagonists as a potential intervention to limit cancer-associated thrombosis, balancing safety with efficacy.

Published
2019
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