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14. Profiling inflammatory response in lesions of cutaneous leishmaniasis patients using a non-invasive sampling method combined with a high-throughput protein detection assay

Author

Taslimi, Yasaman, primary, Agbajogu, Christopher, additional, Brynjolfsson, Siggeir Fannar, additional, Masoudzadeh, Nasrin, additional, Mashayekhi, Vahid, additional, Gharibzadeh, Safoora, additional, Östensson, Malin, additional, Nakka, Sravya Sowdamini, additional, Mizbani, Amir, additional, Rafati, Sima, additional, and Harandi, Ali M., additional

Published
2020
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18. Correction: DNA plasmid coding for Phlebotomus sergenti salivary protein PsSP9, a member of the SP15 family of proteins, protects against Leishmania tropica

Author

Gholami, Elham, primary, Oliveira, Fabiano, additional, Taheri, Tahereh, additional, Seyed, Negar, additional, Gharibzadeh, Safoora, additional, Gholami, Nasim, additional, Mizbani, Amir, additional, Zali, Fatemeh, additional, Habibzadeh, Sima, additional, Bakhadj, Daniel Omid, additional, Meneses, Claudio, additional, Kamyab-Hesari, Kambiz, additional, Sadeghipour, Alireza, additional, Taslimi, Yasaman, additional, khadir, Fatemeh, additional, Kamhawi, Shaden, additional, Mazlomi, Mohammad Ali, additional, Valenzuela, Jesus G., additional, and Rafati, Sima, additional

Published
2019
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19. DNA plasmid coding for Phlebotomus sergenti salivary protein PsSP9, a member of the SP15 family of proteins, protects against Leishmania tropica

Author

Gholami, Elham, primary, Oliveira, Fabiano, additional, Taheri, Tahereh, additional, Seyed, Negar, additional, Gharibzadeh, Safoora, additional, Gholami, Nasim, additional, Mizbani, Amir, additional, Zali, Fatemeh, additional, Habibzadeh, Sima, additional, Bakhadj, Daniel Omid, additional, Meneses, Claudio, additional, Kamyab-Hesari, Kambiz, additional, Sadeghipour, Alireza, additional, Taslimi, Yasaman, additional, khadir, Fatemeh, additional, Kamhawi, Shaden, additional, Mazlomi, Mohammad Ali, additional, Valenzuela, Jesus G., additional, and Rafati, Sima, additional

Published
2019
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20. Comparison of Protective Potency of DNA and Live Vaccines Expressing A2-CPA-CPB-CTE Antigens against Visceral Leishmaniasis in Syrian Hamster as Preliminary Study.

Author

TASLIMI, Yasaman, ZAHEDIFARD, Farnaz, TAHERI, Tahereh, DOROUD, Delaram, LATIF DIZAJI, Sakineh, SALJOUGHIAN, Noushin, and RAFATI, Sima

Subjects
*GOLDEN hamster, *VISCERAL leishmaniasis, *CATIONIC lipids, *DNA vaccines, *HUMORAL immunity, *BODY burden
Abstract

Background: Visceral leishmaniasis is the most severe form of leishmaniasis caused by Leishmania (L.) donovani complex. Drug-resistant strains have been developed as a consequence of the current chemotherapeutic interventions, which has increased the need for advanced preventive and therapeutic strategies. A2-CPA-CPB-CTE-recombinant strain of L. tarentolae, which is non-pathogenic to humans, was shown protective in live vaccine as well as its DNA vaccine counter-part in both murine and canine models. Methods: We evaluated the effectiveness of these DNA and live vaccination harboring A2-CPA-CPB-CTEin protecting hamsters against L. infantum infection using prime-boost regimens, namely DNA/DNA and Live/Live (n=9 hamsters per group). Cationic solid lipid nanoparticles (cSLN) were utilized as an adjuvant for DNA priming and electroporation for boosting DNA. At different time points post-challenge, parasite burden and body weight as well as humoral immune responses were measured. Results: Both immunization strategies partially protect hamsters against L. infantum challenge. This protective immunity is associated with remarkable decrease in parasite load in liver and spleen of vaccinated hamsters eight weeks after challenge compared to control group. Conclusion: Both test groups (DNA/DNA and Live/Live) elicited high levels of IgG2 and total IgG as humoral immune responses and lower level of parasite propagation in both liver and spleen. [ABSTRACT FROM AUTHOR]

Published
2020

21. Role of polymorphisms of the endothelial nitric oxide synthase gene in predicting slow-flow phenomenon after primary percutaneous coronary intervention.

Author

Kiani, Reza, Alilou, Sanam, Rafatnia, Shirin, Taslimi, Yasaman, Habibzadeh, Sima, Gharibzadeh, Safoora, Rafati, Sima, Firouzi, Ata, Rahimi, Shahin, Zahedmehr, Ali, Mehrvarz, Farzaneh, Mahari, Mehrdad Moghadam, Hamediseresht, Marjohn, and Sadeghipour, Parham

Abstract

Copyright of Archives of the Turkish Society of Cardiology / Türk Kardiyoloji Derneği Arşivi is the property of KARE Publishing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2020
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28. Hoarseness as the Presenting Symptom of Visceral Leishmaniasis with Muco-Cutaneous Lesions: A Case Report

Author

MORTAZAVI, Hossein, MOHEBALI, Mehdi, TASLIMI, Yasaman, SADEGHIPOUR, Pardis, ANSARI, Mahsa, KAMYAB, Kambiz, TALEBI, Marjan, and KHAMESIPOUR, Ali

Subjects
Visceral, Hoarseness, PCR, Case Report, lcsh:RC109-216, Leishmaniasis, Leishmania major, lcsh:Infectious and parasitic diseases
Abstract

Herein, a 28-year-old man with hoarseness, skin and oral lesions is presented. At the time of admission, the patient had an erythematous plaque on his chin near his lower lip and an erythematous-violaceous plaque on his palate near the open-ing of the pharynx and 20 kg weight lost in last one year. The biopsy of his skin lesions by hematoxylin and eosin staining revealed an infiltration of the dermis by lymphoplasma and histiocytic cells with a loose granuloma formation sugges-tive of leishmaniasis. Biopsy of mucosal lesions revealed Leishman bodies in dermis. PCR was performed on the specimens of skin, bone marrow, mucosa, and saliva, the results were positive. The pathogenic agent was identified as Leishmania major by the nested PCR. Serologic tests including direct agglutination test (DAT) and indirect immunofluorescence test (IFAT) were positive with high titers of anti-L. infantum antibodies (1:102400 versus 1:800, respectively), indicative of visceral involvement. The patient responded to a combination of miltefosine and meglumine antimoniate (Glucantime®). Visceral involvement due to L. major is rarely reported. To the best of our knowledge, probably hoarseness due to L. major has not been previously reported from Iran.

Published
2015

31. The contribution of NT-gp96 as an adjuvant for increasing HPV16 E7-specific immunity in C57BL /6 mouse model

Author

Mohit, Elham, Bolhassani, Azam, Zahedifard, Farnaz, Taslimi, Yasaman, Rafati, Sima, Institut Pasteur d'Iran, and Réseau International des Instituts Pasteur (RIIP)

Subjects
Human papillomavirus 16, Immunity, Cellular, Vaccines, Synthetic, Papillomavirus E7 Proteins, Papillomavirus Infections, Uterine Cervical Neoplasms, Viral Vaccines, Antibodies, Viral, Statistics, Nonparametric, Immunity, Humoral, Mice, Inbred C57BL, Disease Models, Animal, Mice, Adjuvants, Immunologic, Animals, Female, Immunization, [SDV.IMM.VAC]Life Sciences [q-bio]/Immunology/Vaccinology, Glycoproteins
Abstract

International audience; To control cervical cancer, efficient vaccination against human papillomavirus (HPV) is highly required. Despite the advantages and safety of the protein vaccines, additional strategies to enhance their immunogenicity are needed. E7 is a transforming protein which represents a perfect target antigen for vaccines or immunotherapies. Heat shock proteins (HSPs) facilitate cellular immune responses to antigenic peptides or proteins bound to them. Regarding to previous studies, vaccination with purified HSP ⁄ antigen complexes efficiently elicit antigen-specific immune responses in mice model. The N-terminal of glycoprotein 96 (NT-gp96) has adjuvant effect and can induce effective cumulative immune response against clinical disorders, especially cancers. In this study, the recombinant HPV16 E7 and E7 linked to NT-gp96 (E7-NT-gp96) proteins were generated in prokaryotic expression system. Mice were vaccinated twice with this recombinant proteins and the immunogenicity of the fusion protein was determined. The preventive efficacy of E7-NT-gp96 fusion protein was also evaluated and compared to E7 protein after challenging with cancerous TC-1 cell line. In vitro re-stimulated splenocytes of mice vaccinated with rE7-NT-gp96 protein induced higher IFN-c response in comparison with E7 protein immunization. Moreover, immunization with E7-NT-gp96 protein displayed low but stable humoral responses at post-challenge time. The data showed that vaccination with fused E7-NT-gp96 protein delayed the tumour occurrence and growth as compared to protein E7 alone. These results suggest that fused adjuvant-free E7-NT-gp96 protein vaccination could direct the immune responses towards Th1 immunity. Furthermore, the linkage of NTgp96 to E7 could enhance protective anti-tumour immunity.

Published
2011

32. Evaluation of Live Recombinant Nonpathogenic Leishmania tarentolae Expressing Cysteine Proteinase and A2 Genes as a Candidate Vaccine against Experimental Canine Visceral Leishmaniasis

Author

Shahbazi, Mehdi, primary, Zahedifard, Farnaz, additional, Taheri, Tahereh, additional, Taslimi, Yasaman, additional, Jamshidi, Shahram, additional, Shirian, Sadegh, additional, Mahdavi, Niousha, additional, Hassankhani, Mehdi, additional, Daneshbod, Yahya, additional, Zarkesh-Esfahani, Sayyed Hamid, additional, Papadopoulou, Barbara, additional, and Rafati, Sima, additional

Published
2015
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34. Enhanced Protective Efficacy of Nonpathogenic Recombinant Leishmania tarentolae Expressing Cysteine Proteinases Combined with a Sand Fly Salivary Antigen

Author

Zahedifard, Farnaz, primary, Gholami, Elham, additional, Taheri, Tahereh, additional, Taslimi, Yasaman, additional, Doustdari, Fatemeh, additional, Seyed, Negar, additional, Torkashvand, Fatemeh, additional, Meneses, Claudio, additional, Papadopoulou, Barbara, additional, Kamhawi, Shaden, additional, Valenzuela, Jesus G., additional, and Rafati, Sima, additional

Published
2014
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36. Development of Novel Prime-Boost Strategies Based on a Tri-Gene Fusion Recombinant L. tarentolae Vaccine against Experimental Murine Visceral Leishmaniasis

Author

Saljoughian, Noushin, primary, Taheri, Tahereh, additional, Zahedifard, Farnaz, additional, Taslimi, Yasaman, additional, Doustdari, Fatemeh, additional, Bolhassani, Azam, additional, Doroud, Delaram, additional, Azizi, Hiva, additional, Heidari, Kazem, additional, Vasei, Mohammad, additional, Namvar Asl, Nabiollah, additional, Papadopoulou, Barbara, additional, and Rafati, Sima, additional

Published
2013
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45. Hoarseness as the Presenting Symptom of Visceral Leishmania-sis with Muco-Cutaneous Lesions: A Case Report.

Author

MORTAZAVI, Hossein, MOHEBALI, Mehdi, TASLIMI, Yasaman, SADEGHIPOUR, Pardis, ANSARI, Mahsa, KAMYAB, Kambiz, TALEBI, Marjan, and KHAMESIPOUR, Ali

Subjects
LEISHMANIASIS, HOARSENESS, LEISHMANIA major, IMMUNOGLOBULINS, SEROLOGY
Abstract

Herein, a 28-year-old man with hoarseness, skin and oral lesions is presented. At the time of admission, the patient had an erythematous plaque on his chin near his lower lip and an erythematous-violaceous plaque on his palate near the opening of the pharynx and 20 kg weight lost in last one year. The biopsy of his skin lesions by hematoxylin and eosin staining revealed an infiltration of the dermis by lymphoplasma and histiocytic cells with a loose granuloma formation suggestive of leishmaniasis. Biopsy of mucosal lesions revealed Leishman bodies in dermis. PCR was performed on the specimens of skin, bone marrow, mucosa, and saliva, the results were positive. The pathogenic agent was identified as Leishmania major by the nested PCR. Serologic tests including direct agglutination test (DAT) and indirect immunofluorescence test (IFAT) were positive with high titers of anti-L. infantum antibodies (1:102400 versus 1:800, respectively), indicative of visceral involvement. The patient responded to a combination of miltefosine and meglumine antimoniate (Glucantime®). Visceral involvement due to L. major is rarely reported. To the best of our knowledge, probably hoarseness due to L. major has not been previously reported from Iran. [ABSTRACT FROM AUTHOR]

Published
2015

48. Enhanced Protective Efficacy of Nonpathogenic Recombinant Leishmania tarentolae Expressing Cysteine Proteinases Combined with a Sand Fly Salivary Antigen.

Author

Zahedifard, Farnaz, Gholami, Elham, Taheri, Tahereh, Taslimi, Yasaman, Doustdari, Fatemeh, Seyed, Negar, Torkashvand, Fatemeh, Meneses, Claudio, Papadopoulou, Barbara, Kamhawi, Shaden, Valenzuela, Jesus G., and Rafati, Sima

Subjects
LEISHMANIA, RECOMBINANT antibodies, CYSTEINE proteinases, ANTIGENS, INTRACELLULAR pathogens
Abstract

Background: Novel vaccination approaches are needed to prevent leishmaniasis. Live attenuated vaccines are the gold standard for protection against intracellular pathogens such as Leishmania and there have been new developments in this field. The nonpathogenic to humans lizard protozoan parasite, Leishmania (L) tarentolae, has been used effectively as a vaccine platform against visceral leishmaniasis in experimental animal models. Correspondingly, pre-exposure to sand fly saliva or immunization with a salivary protein has been shown to protect mice against cutaneous leishmaniasis. Methodology/Principal Findings: Here, we tested the efficacy of a novel combination of established protective parasite antigens expressed by L. tarentolae together with a sand fly salivary antigen as a vaccine strategy against L. major infection. The immunogenicity and protective efficacy of different DNA/Live and Live/Live prime-boost vaccination modalities with live recombinant L. tarentolae stably expressing cysteine proteinases (type I and II, CPA/CPB) and PpSP15, an immunogenic salivary protein from Phlebotomus papatasi, a natural vector of L. major, were tested both in susceptible BALB/c and resistant C57BL/6 mice. Both humoral and cellular immune responses were assessed before challenge and at 3 and 10 weeks after Leishmania infection. In both strains of mice, the strongest protective effect was observed when priming with PpSP15 DNA and boosting with PpSP15 DNA and live recombinant L. tarentolae stably expressing cysteine proteinase genes. Conclusion/Significance: The present study is the first to use a combination of recombinant L. tarentolae with a sand fly salivary antigen (PpSP15) and represents a novel promising vaccination approach against leishmaniasis. [ABSTRACT FROM AUTHOR]

Published
2014
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50. Antibody detection against HPV16 E7 & GP96 fragments as biomarkers in cervical cancer patients.

Author

Bolhassani, Azam, Zahedifard, Farnaz, Taslimi, Yasaman, Taghikhani, Mohammad, Nahavandian, Bijan, and Rafati, Sima

Subjects
*CANCER, *TUMOR markers, *CERVICAL cancer diagnosis, *PAPILLOMAVIRUS diseases, *RECOMBINANT proteins, *HEAT shock proteins, *SERODIAGNOSIS
Abstract

Background & objectives: Cervical cancer is the second most frequent cancer among females worldwide, especially human papilloma viruses (HPV) types 16 and 18. In viral systems the identification of serological markers would facilitate the diagnosis of HPV infections and virus-related disease. The aim of the present investigation was to determine and search for serologic markers in cervical cancer patients associated with HPV. Methods: A total of 58 Iranian women with invasive cervical carcinoma including adenocarcinoma and squamous cell carcinoma (SCC) were included. Serum antibody response to HPV infections in patients was detected by Western blot and ELISA techniques based on recombinant HPVI 6E7 and the N-terminal and C-terminal fragments of gp96 (NT-gp96 and CT-gp96) proteins. These recombinant proteins were expressed in Escherichia coli as a His-tag protein and purified using affinity chromatography. Results: The ELISA results indicated that patients with high antibody response to HPVI6E7 had significant seroreactivity to CT-gp96 fragment. In Western blot analysis, a strong association between anti-E7, anti-NT-gp96 and anti-CT-gp96 reactivity and cervical cancer was obtained using purified recombinant proteins. In adenocarcinoma cases, no significant difference was observed in seroreactivities between normal and patients. Interpretation & conclusions: The evaluation of cervical cancer patients' seroreactivities against three recombinant proteins (rE7, rNT-gp96 and rCT-gp96) showed significantly higher levels of these markers in SCC only, but not in adenocarcinoma and control groups. Also, the usage of both techniques (ELISA and Western blotting) can provide more reliable tools for diagnosis of cervical cancer. [ABSTRACT FROM AUTHOR]

Published
2009

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