1. Collaborative care for common mental disorders in low- and middle-income countries: A systematic review and meta-analysis.
- Author
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Faisal, Mehreen Riaz, Salam, Fakiha Tus, Vidyasagaran, Aishwarya Lakshmi, Carswell, Claire, Naseri, Mohammad Wali, Shinwari, Zalmai, Fulbright, Helen, Zavala, Gerardo A., Gilbody, Simon, and Siddiqi, Najma
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TASK shifting , *MIDDLE-income countries , *RANDOMIZED controlled trials , *HIGH-income countries , *INTEGRATED health care delivery - Abstract
Low- and middle-income countries (LMICs) face high burden of common mental disorders (CMDs). Most of the evidence for the Collaborative Care (CC) model effectiveness comes from high-income countries (HICs) and may not generalise to LMICs. A systematic review was conducted to assess effectiveness of CC for CMDs in LMICs. We searched eight-databases, two trial registries (2011-November 2023). Randomised controlled trials (RCTs) of adults (≥18 years) with depression/anxiety diagnosis, reporting remission/change in symptom severity were eligible. Random effects meta-analyses were conducted for: short-(0–6 months), medium-(7–12 months), long-(13–24 months), and very long-term (≥25 months) follow-up. Quality was assessed with Cochrane RoB2 tool. PROSPERO registration: CRD42022380407. Searches identified 7494 studies, 12 trials involving 13,531 participants were included; nine had low-risk of bias. CC was more effective than usual care for depression: dichotomous outcomes (short-term, 7 studies, relative risk (RR) 1.39, 95%CI 1.31, 1.48; medium-term, 6 studies, RR 1.35, 95%CI 1.28, 1.43); and continuous outcomes (short-term, 8 studies, standardised mean difference (SMD) −0.51, 95%CI −0.80, −0.23; medium-term, 8 studies, SMD −0.59, 95%CI −1.00, −0.17). CC was found to be effective at long-term (one study), but not at very long-term. Improvement in anxiety outcomes with CC (2 studies, 340 participants) reported up to 12-months; improvements in quality-of-life were not statistically significant (3 studies, 796 participants, SMD 0.62, 95%CI −0.10, 1.34). Pooled estimates showed high heterogeneity. In LMICs, CC was more effective than usual care for improving depression outcomes at short and medium-term follow-up. A similar improvement was found for anxiety outcomes, but evidence is limited. • Collaborative Care shows effectiveness for treatment of common mental disorders. • Effectiveness established even in the presence of physical comorbidity. • Delivery through task shifting by trained non-mental health workers is effective. • Future research to focus on implementation in low- and middle-income countries [ABSTRACT FROM AUTHOR]
- Published
- 2024
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