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2. A Novel Color-Coded Liver Metastasis Mouse Model to Distinguish Tumor and Adjacent Liver Segment

Author

Nishino, Hiroto, Hollandsworth, Hannah M, Amirfakhri, Siamak, Tashiro, Yoshihiko, Yamamoto, Jun, Turner, Michael A, Lwin, Thinzar M, Singer, Bernhard B, Hoffman, Robert M, and Bouvet, Michael

Subjects
Liver Disease, Biotechnology, Colo-Rectal Cancer, Digestive Diseases, Cancer, Animals, Antibodies, Monoclonal, Carcinoembryonic Antigen, Colonic Neoplasms, Color, Fluorescent Dyes, GPI-Linked Proteins, Hepatectomy, Humans, Indocyanine Green, Injections, Intravenous, Liver, Liver Neoplasms, Mice, Molecular Imaging, Optical Imaging, Xenograft Model Antitumor Assays, Liver metastases, Colon cancer, Nude mouse model, Indocyanine green, Fluorescent tumor-specific antibody, CEACAM, Color-coded fluorescence imaging, Clinical Sciences, Surgery
Abstract

BackgroundIt is difficult to distinguish between a tumor and its liver segment with traditional use of indocyanine green (ICG) alone. In the present study, a method was used to limit ICG to the liver segment adjacent to a tumor. A spectrally-distinct fluorescently-labeled tumor-specific antibody against human carcinoembryonic antigen-related cell-adhesion molecules was used to label the metastatic tumor in a patient-derived orthotopic xenograft mouse model to enable color-coded visualization and distinction of a colon-cancer liver metastases and its adjacent liver segment.Materials and methodsNude mice received surgical orthotopic implantation in the liver of colon-cancer liver metastases derived from two patients. An anti- carcinoembryonic antigen-related cell-adhesion molecules monoclonal antibody (mAb 6G5j) was conjugated to a near-infrared dye IR700DX (6G5j-IR700DX). After three weeks, mice received 6G5j-IR700DX via tail-vein injection 48 hours before surgery. ICG was intravenously injected after ligation of the left or left lateral Glissonean pedicle resulting in labeling of the segment with preserved blood-flow in the liver. Imaging was performed with the Pearl Trilogy and FLARE Imaging Systems.ResultsThe metastatic liver tumor had a clear fluorescence signal due to selective tumor targeting by 6G5j-IR700DX, which was imaged on the 700 nm channel. The adjacent liver segment, with preserved blood-flow in the liver, had a clear fluorescence ICG 800 nm signal, while the left or left lateral segment had no fluorescence signal. Overlay of the images showed clear color-coded differentiation between the tumor fluorescing at 700 nm and the adjacent liver segment fluorescing at 800 nm.ConclusionsColor-coding of a liver tumor and uninvolved liver segment has the potential for improved liver resection.

Published
2021

3. PPARγ Agonist Pioglitazone in Combination With Cisplatinum Arrests a Chemotherapy-resistant Osteosarcoma PDOX Model

Author

HIGUCHI, TAKASHI, YAMAMOTO, JUN, SUGISAWA, NORIHIKO, TASHIRO, YOSHIHIKO, NISHINO, HIROTO, YAMAMOTO, NORIO, HAYASHI, KATSUHIRO, KIMURA, HIROAKI, MIWA, SHINJI, IGARASHI, KENTARO, BOUVET, MICHAEL, SINGH, SHREE RAM, TSUCHIYA, HIROYUKI, and HOFFMAN, ROBERT M

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Orphan Drug, Pediatric, Rare Diseases, Pediatric Cancer, Clinical Research, Cancer, Adolescent, Animals, Antibiotics, Antineoplastic, Antineoplastic Agents, Apoptosis, Bone Neoplasms, Cell Proliferation, Cisplatin, Doxorubicin, Drug Resistance, Neoplasm, Drug Therapy, Combination, Humans, Hypoglycemic Agents, Male, Mice, Mice, Nude, Osteosarcoma, PPAR gamma, Pioglitazone, Tumor Cells, Cultured, Xenograft Model Antitumor Assays, pioglitazone, cisplatinum, drug resistance, PDOX, PPARγ, Immunology, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

BACKGROUND/AIM:Cisplatinum (CDDP) is a first-line drug in osteosarcoma treatment and the acquisition of resistance to CDDP is associated with a poor prognosis. Peroxisome proliferator-activated receptor gamma (PPARγ) is a nuclear hormone receptor that plays important roles in cell proliferation, differentiation, development, metabolism and cell death. Recently, PPARγ was reported to enhance the efficacy, overcome resistance, and decrease the toxicity of CDDP in various human cancers. In this study we tested whether pioglitazone (PIO), a PPARγ agonist, could overcome CDDP resistance in osteosarcoma. MATERIALS AND METHODS:In this study, we used a human osteosarcoma cell line and a patient-derived orthotopic xenograft (PDOX) models of osteosarcoma. We measured cell viability of 143B human osteosarcoma cells when treated with CDDP and PIO. We randomized PDOX models of osteosarcoma into four treatment groups: Group 1, Untreated control; Group 2, PIO alone; Group 3, CDDP alone; Group 4, a combination of CDDP and PIO. Each group comprised six mice. Mice were treated for 14 days and tumor size and body weight were measured. RESULTS:Cell viability of 143B human osteosarcoma cells was significantly reduced when PIO (50 μmol/l) was combined with CDDP compared to CDDP alone. PDOX osteosarcoma tumors treated with the CDDP-PIO combination showed the strongest tumor growth inhibition compared to other treatment groups. PDOX osteosarcoma tumors treated with the CDDP-PIO combination had the least cancer cells and the most necrosis in histological section. CONCLUSION:These results suggest that combining PIO along with CDDP could be an effective treatment strategy for osteosarcoma and has important clinical potential for patients.

Published
2020

4. Ligation Method to Specifically Label a Liver Segment With Indocyanine Green in an Orthotopic Nude-Mouse Liver-Metastasis Model

Author

NISHINO, HIROTO, HOLLANDSWORTH, HANNAH M, TASHIRO, YOSHIHIKO, YAMAMOTO, JUN, AMIRFAKHRI, SIAMAK, FILEMONI, FILEMONI, SUGISAWA, NORIHIKO, HOFFMAN, ROBERT M, and BOUVET, MICHAEL

Subjects
Liver Disease, Digestive Diseases, Chronic Liver Disease and Cirrhosis, Cancer, Aetiology, 2.1 Biological and endogenous factors, Animals, Humans, Indocyanine Green, Liver Neoplasms, Mice, Mice, Nude, Optical Imaging, Indocyanine green, liver, hepatic segment, labeling, liver metastasis, patient-derived orthotopic xenographt, PDOX, Glissonean pedicle, ligation, imaging, nude mouse, Clinical Sciences, Oncology & Carcinogenesis
Abstract

Background/aimThe visualization of hepatic segments with indocyanine green (ICG) fluorescence can aid in anatomic liver resection. The present study aimed to develop a method to specifically label an hepatic segment in a nude mouse model with liver metastasis.Materials and methodsAn orthotopic mouse model was established by surgical orthotopic implantation (SOI) of a patient-derived colon-cancer liver metastasis in the left lobe of the liver. Three weeks after SOI, the left Glissonean pedicle was ligated and 10 μg ICG was administrated intravenously. Images were obtained with the Pearl Trilogy Imaging System.ResultsAll mice expressed an 800 nm signal from ICG on the right lobe of the liver. The left lobe of the liver, in which the tumor was located, showed no fluorescence and had ischemia due to successful ligation of the Glissonean pedicle.ConclusionThe ligation of the Glissonean pedicle enables specific liver-segment labeling with ICG, which has potential clinical application for liver metastasectomy.

Published
2020

5. Sutureless Surgical Orthotopic Implantation Technique of Primary and Metastatic Cancer in the Liver of Mouse Models

Author

NISHINO, HIROTO, HOLLANDSWORTH, HANNAH M, SUGISAWA, NORIHIKO, YAMAMOTO, JUN, TASHIRO, YOSHIHIKO, INUBUSHI, SACHIKO, HAMADA, KAZUYUKI, SUN, YU, LIM, HYEIN, AMIRFAKHRI, SIAMAK, FILEMONI, FILEMONI, HOFFMAN, ROBERT M, and BOUVET, MICHAEL

Subjects
Liver Disease, Digestive Diseases, Rare Diseases, Cancer, Biotechnology, Liver Cancer, Oral and gastrointestinal, Animals, Carcinoma, Hepatocellular, Disease Models, Animal, Humans, Liver Neoplasms, Mice, Mice, Nude, Neoplasm Transplantation, Hepatocellular carcinoma, colon cancer, liver metastasis, nude mouse, orthotopic, cell line, patient tumor, PDOX, Clinical Sciences, Oncology & Carcinogenesis
Abstract

Background/aimSurgical orthotopic implantation (SOI) is used to establish patient-derived orthotopic xenograft (PDOX) and other orthotopic mouse models. Orthotopic liver models can be challenging, as the liver parenchyma is prone to bleeding. The present report describes a sutureless method to implant tumors in the liver that reduces bleeding and procedural time.Materials and methodsHuman HCC cell-line (Huh-7-GFP) and CM2, a patient-derived colon-cancer liver metastasis, were used for sutureless SOI of tumor fragments in the liver of nude mice. A small cavity was formed on the liver surface. A solitary tumor fragment was implanted in the cavity without suturing to create hemostasis.ResultsSix weeks after sutureless SOI, the tumor volume of Huh-7-GFP (n=5) was 584.41±147.64 mm3 and the tumor volume of CM2 (n=5) was 1336.54±1038.20 mm3 The engraftment rate was 100%.ConclusionThis novel method for establishing orthotopic liver-implantation mouse models is suitable for studies of liver cancer and liver metastases due to its simple procedure and potential high engraftment rate.

Published
2020

6. Ischemia reperfusion-induced metastasis is resistant to PPARγ agonist pioglitazone in a murine model of colon cancer

Author

Tashiro, Yoshihiko, Nishino, Hiroto, Higuchi, Takashi, Sugisawa, Norihiko, Fukuda, Yasunari, Yamamoto, Jun, Inubushi, Sachiko, Aoki, Takeshi, Murakami, Masahiko, Singh, Shree Ram, Bouvet, Michael, and Hoffman, Robert M

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Liver Disease, Digestive Diseases, Cancer, Colo-Rectal Cancer, Aetiology, 2.1 Biological and endogenous factors, Animals, Colonic Neoplasms, Cytokines, Disease Models, Animal, Disease Progression, Inflammation, Liver, Liver Neoplasms, Mice, Mice, Inbred C57BL, Neoplasm Metastasis, PPAR gamma, Pioglitazone, Reperfusion Injury, Spleen
Abstract

Ischemia reperfusion injury (IRI) during liver-metastasis resection for treatment of colon cancer may increase the risk of further metastasis. Peroxisome proliferator-activated receptor-γ (PPARγ) activation has been observed to exert a protective effect against IRI and IRI-induced metastasis of hepatocellular carcinoma. The present study aimed to investigate the effect of the PPARγ agonist pioglitazone on tumor metastasis and liver injury following IRI in a mouse model of colon cancer. Pioglitazone (30 mg/kg weight) was administered orally 1.5 h before and 2 h after the initiation of ischemia and was orally administrated daily to mice from day 0-21. SL4-cancer cells expressing red fluorescent protein (SL4-RFP) (1 × 106) were injected into the spleen. Fifteen minutes after injection, the hepatoduodenal ligament was clamped with a vessel clip, and released 5 min later. Liver, blood and tumor samples were taken from mice in order to determine if inflammation was induced by IRI. The effect of pioglitazone on liver metastasis was assessed. Furthermore, the effect of pioglitazone to control the inflammatory response during IRI progression was examined. Liver metastasis along with MMP-9 activation and the production of inflammatory cytokines were resistant to pioglitazone. Our results indicate that liver metastasis and associated inflammation in mice were resistant to pioglitazone.

Published
2020

10. A novel image-guided laparoscopic liver resection with integrated fluorescent imaging and artificial intelligence: A preliminary study.

Author

Tashiro, Yoshihiko, primary, Aoki, Takeshi, additional, Kobayashi, Nao, additional, Kumazu, Yuta, additional, Tomioka, Kodai, additional, Saito, Kazuhiko, additional, Yamazaki, Tatsuya, additional, Hirai, Takahito, additional, Shibata, Hideki, additional, Date, Hiromi, additional, Watanabe, Ryohei, additional, Matsuda, Kazuhiro, additional, Kusano, Tomokazu, additional, Yamazaki, Kimiyasu, additional, and Watanabe, Makoto, additional

Published
2024
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11. Simple classification system for predicting the difficulty level of laparoscopic cholecystectomy

Author

Hirai, Takahito, primary, Aoki, Takeshi, additional, Sasamoto, Suguru, additional, Iseki, Sadahito, additional, Shinohara, Yukari, additional, Yamazaki, Tatsuya, additional, Saito, Kazuhiko, additional, Uchida, Marie, additional, Tomioka, Kodai, additional, Shibata, Hideki, additional, Wada, Yusuke, additional, Tashiro, Yoshihiko, additional, Nogaki, Koji, additional, Matsuda, Kazuhiro, additional, Kusano, Tomokazu, additional, Fujimori, Akira, additional, Enami, Yuta, additional, Kato, Takashi, additional, and Murakami, Masahiko, additional

Published
2024
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14. Experience of the pancreas duodenectomy for so-called carcinosarcoma of the common bile duct:a case report and review of literature

Author

Sasamoto, Suguru, Aoki, Takeshi, Tashiro, Yoshihiko, Matsuda, Kazuhiro, Koizumi, Tomotake, Kusano, Tomokazu, Wada, Yusuke, Shibata, Hideki, Tomioka, Kodai, Yamashita, Takeshi, Date, Hiromi, Ariyoshi, Tomotake, Goto, Satoru, Yamazaki, Kimiyasu, Fujimori, Akira, Watanabe, Makoto, Enami, Yuta, Otsuka, Koji, Norose, Tomoko, Ohike, Nobuyuki, Yamochi, Toshiko, Takimoto, Masafumi, and Murakami, Masahiko

Published
2021
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16. Development of a Novel Artificial Intelligence System for Laparoscopic Hepatectomy

Author

TOMIOKA, KODAI, primary, AOKI, TAKESHI, additional, KOBAYASHI, NAO, additional, TASHIRO, YOSHIHIKO, additional, KUMAZU, YUTA, additional, SHIBATA, HIDEKI, additional, HIRAI, TAKAHITO, additional, YAMAZAKI, TATSUYA, additional, SAITO, KAZUHIKO, additional, YAMAZAKI, KIMIYASU, additional, WATANABE, MAKOTO, additional, MATSUDA, KAZUHIRO, additional, KUSANO, TOMOKAZU, additional, FUJIMORI, AKIRA, additional, and ENAMI, YUTA, additional

Published
2023
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18. Virtual reality with three-dimensional image guidance of individual patients’ vessel anatomy in laparoscopic distal pancreatectomy

Author

Aoki, Takeshi, Koizumi, Tomotake, Mansour, Doaa A., Fujimori, Akira, Kusano, Tomokazu, Matsuda, Kazuhiro, Nogaki, Koji, Tashiro, Yoshihiko, Hakozaki, Tomoki, Wada, Yusuke, Shibata, Hideki, Tomioka, Kodai, Hirai, Takahito, Yamazaki, Tatsuya, Saito, Kazuhiko, Enami, Yuta, Koike, Reiko, Mitamura, Keitaro, Yamada, Kosuke, Watanabe, Makoto, Otsuka, Koji, and Murakami, Masahiko

Published
2020
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20. List of contributors

Author

Aleman, Rene, primary, Aoki, Takeshi, additional, Bouvet, Michael, additional, Cao, Hop S. Tran, additional, Choyke, Peter L., additional, Dip, Fernando, additional, Durkin, Claire, additional, Falco, Jorge, additional, Gioux, Sylvain, additional, Hiroshima, Yukihiko, additional, Ho, Jason, additional, Hoffman, Robert M., additional, Hollandsworth, Hannah M., additional, Ishizawa, Takeaki, additional, Kawaguchi, Yoshikuni, additional, Kobayashi, Hisataka, additional, Koizumi, Tomotake, additional, Krishna, Somashekar G., additional, Kuasano, Tomokazu, additional, Mansour, Doaa A., additional, Menzo, Emanuele Lo, additional, Metildi, Cristina A., additional, Miwa, Shinji, additional, Murakami, Masahiko, additional, Murakami, Takashi, additional, Nagaya, Tadanobu, additional, Nakamura, Yu A., additional, Nishino, Hiroto, additional, Oyefule, Omobolanle, additional, Rosenthal, Raul J., additional, Roy, Mayank, additional, Saiura, Akio, additional, Szomstein, Samuel, additional, Takahashi, Naoto, additional, Tashiro, Yoshihiko, additional, Turner, Michael, additional, Uehara, Fuminari, additional, and Yano, Shuya, additional

Published
2020
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26. Advances of Intraoperative Fluorescence Imaging in Hepato-biliary-pancreatic Surgery

Author

Tomioka, Kodai, primary, Aoki, Takeshi, additional, Kusano, Tomokazu, additional, Matsuda, Kazuhiro, additional, Nogaki, Koji, additional, Tashiro, Yoshihiko, additional, Wada, Yusuke, additional, Shibata, Hideki, additional, Yamazaki, Tatsuya, additional, Saito, Kazuhiko, additional, Uchida, Marie, additional, Nagaishi, Shodai, additional, Fujimori, Akira, additional, and Enami, Yuta, additional

Published
2023
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28. Linkage of methionine addiction, histone lysine hypermethylation, and malignancy

Author

Yamamoto, Jun, primary, Inubushi, Sachiko, additional, Han, Qinghong, additional, Tashiro, Yoshihiko, additional, Sugisawa, Norihiko, additional, Hamada, Kazuyuki, additional, Aoki, Yusuke, additional, Miyake, Kentaro, additional, Matsuyama, Ryusei, additional, Bouvet, Michael, additional, Clarke, Steven G., additional, Endo, Itaru, additional, and Hoffman, Robert M., additional

Published
2022
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31. Indocyanine Green Labeling of Tumors in the Liver Recurring After Radiofrequency Ablation Enables Complete Resection by Fluorescence-guided Surgery

Author

TASHIRO, YOSHIHIKO, primary, AOKI, TAKESHI, additional, HIRAI, TAKAHITO, additional, KOIZUMI, TOMOTAKE, additional, KUSANO, TOMOKAZU, additional, MATSUDA, KAZUHIRO, additional, YAMADA, KOSUKE, additional, NOGAKI, KOJI, additional, HAKOZAKI, TOMOKI, additional, WADA, YUSUKE, additional, SHIBATA, HIDEKI, additional, TOMIOKA, KODAI, additional, YAMAZAKI, TATSUYA, additional, SAITO, KAZUHIKO, additional, FUJIMORI, AKIRA, additional, ENAMI, YUTA, additional, and HOFFMAN, ROBERT M., additional

Published
2022
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33. The Prognosis for Unexpected Gallbladder Carcinoma with Bile Spillage during Laparoscopic Cholecystectomy

Author

KOIZUMI, Tomotake, AOKI, Takeshi, ENAMI, Yuta, FUJIMORI, Akira, KUSANO, Tomokazu, MATSUDA, Kazuhiro, YAMADA, Kosuke, NOGAKI, Koji, TASHIRO, Yoshihiko, and MURAKAMI, Masahiko

Subjects
urologic and male genital diseases
Abstract

Here we review the prognosis of patients with unsuspected gallbladder carcinoma（GBC）, detected after laparoscopic cholecystectomy（LC）in a single institute. We reviewed the medical records of patients diagnosed with gallbladder stones on admission, who underwent LC. Carcinoma involving the gallbladder was found in 22 of 2,770 patients（0.9％）via postoperative pathological examination. This GBC group spanned 58-87 years of age（mean, 75 years; 13 females and 9 males）. The preoperative diagnosis was gallbladder stones with acute/chronic cholecystitis or adenomyomatosis of the gallbladder in all patients. We performed an additional surgery in 6 of 15 patients with pT2 and T3 disease; of these, 3 patients with pT2 disease and 1 with pT3 experienced bile spillage during the LC. The mean survival of patients with unexpected GBC was 21 months, with bile spillage occurring as a complication of LC identified as a potential risk factor for shorter survival（15.3 vs. 32.5 months）. We identified patients with pT2 and pT3 disease after LC, and two patients with pT2 and 1 with pT3 who had bile spillage during LC died of peritoneal dissemination within 28 months, despite additional surgery. Occasional seeding caused by bile spillage during LC should be carefully avoided to minimize the risk of developing unsuspected GBC after LC.

Published
2019

34. The Surgical Benefits of Repeat Hepatectomy for Colorectal Liver Metastasis

Author

KUSANO, Tomokazu, AOKI, Takeshi, YAMAZAKI, Tatsuya, HIRAI, Takashi, TOMIOKA, Koudai, SHIBATA, Hideki, WADA, Yuusuke, HAKOZAKI, Tomoki, TASHIRO, Yoshihiko, NOGAKI, Kouji, MATSUDA, Kazuhiro, YAMADA, Kousuke, KOIZUMI, Tomotake, MITAMURA, Keitaro, FUJIMORI, Akira, KOIKE, Reiko, ENAMI, Yuta, and MURAKAMI, Masahiko

Abstract

The most common site of distant metastasis from colorectal cancer is the liver, and hepatectomy presents the best curative treatment for recurrence of colorectal liver metastasis （CRLM）. This study aimed to identify factors of prognostic value for repeat hepatectomy for CRLM and to determine whether a third such procedure could similarly produce favourable outcomes for CRLM. We analyzed data for 161 patients in our department with colorectal metastasis. Of these, 22 patients underwent repeat hepatectomy for recurrent metastasis, with 16 undergoing a second hepatectomy and 6 a third hepatectomy. We analyzed patient characteristics, tumor status, operation-related variables, and short- and long-term outcomes. Univariate analysis for repeat hepatectomy identified the following five prognostic risk factors: T factor （＞SE） of the primary cancer, number of tumors involved in the initial hepatectomy （＞5）, interval from first to second hepatectomy （＜1year）, number of tumors involved in second hepatectomy （＞3）, and post-operation time （＞30days）. By multivariate analysis, T factor （＞SE） of the primary cancer, number of tumors in the initial hepatectomy （＞5）, and number of tumors in the second hepatectomy （＞3） were independently associated with a worse survival after surgery for CRLM. Although surgical outcomes of the third hepatectomy were not compared with those of the first and second hepatectomy, there were no obvious differences, nor did the 1-, 3-, and 5-year survival rates differ significantly among the three groups. Repeat hepatectomy for CRLM could improve long-term survival. In addition, patients undergoing a third hepatectomy showed a similar survival benefit to those having one or two resections.

Published
2019

35. Determinative Structural Features Identified With Probe-based Confocal Endomicroscopy for the Accurate Diagnosis of Gallbladder Malignancy

Author

KOIZUMI, TOMOTAKE, primary, AOKI, TAKESHI, additional, YAMOCHI, TOSHIKO, additional, TASHIRO, YOSHIHIKO, additional, YAMAZAKI, TATSUYA, additional, KUSANO, TOMOKAZU, additional, MATSUDA, KAZUHIRO, additional, WADA, YUSUKE, additional, SHIBATA, HIDEKI, additional, SAITO, KAZUHIKO, additional, NOGAKI, KOJI, additional, HAKOZAKI, TOMOKI, additional, TOMIOKA, KODAI, additional, HIRAI, TAKAHITO, additional, FUJIMORI, AKIRA, additional, MANSOUR, DOAA A., additional, ABBAS GAHIN, AHMED ELEWA, additional, and HOFFMAN, ROBERT M., additional

Published
2021
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36. Extent and Instability of Trimethylation of Histone H3 Lysine Increases With Degree of Malignancy and Methionine Addiction

Author

YAMAMOTO, JUN, primary, AOKI, YUSUKE, additional, INUBUSHI, SACHIKO, additional, HAN, QINGHONG, additional, HAMADA, KAZUYUKI, additional, TASHIRO, YOSHIHIKO, additional, MIYAKE, KENTARO, additional, MATSUYAMA, RYUSEI, additional, BOUVET, MICHAEL, additional, CLARKE, STEVEN G., additional, ENDO, ITARU, additional, and HOFFMAN, ROBERT M., additional

Published
2021
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37. Comparison of Endotoxin Activity Assay and Various Biomarkers for Severity Assessment in Colorectal Perforation Patients

Author

Matsuda, Kazuhiro, primary, Aoki, Takeshi, additional, Watanabe, Makoto, additional, Tomioka, Kodai, additional, Tashiro, Yoshihiko, additional, Tomokazu, Kusano, additional, Koizumi, Tomotake, additional, Satoru, Goto, additional, Yamazaki, Kimiyasu, additional, Otsuka, Koji, additional, and Murakami, Masahiko, additional

Published
2021
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42. Indocyanine Green Fluorescence Image-guided Laparoscopic Hepatectomy Enabled Resection of a Tumor Invisible With Ultrasonography

Author

OURA, KEISUKE, primary, AOKI, TAKESHI, additional, TASHIRO, YOSHIHIKO, additional, MATSUDA, KAZUHIRO, additional, KOIZUMI, TOMOTAKE, additional, KUSANO, TOMOKAZU, additional, WADA, YUSUKE, additional, SHIBATA, HIDEKI, additional, YAMASHITA, TAKESHI, additional, DATE, HIROMI, additional, ARIYOSHI, TOMOTAKE, additional, GOTO, SATORU, additional, YAMAZAKI, KIMIYASU, additional, WATANABE, MAKOTO, additional, FUJIMORI, AKIRA, additional, ENAMI, YUTA, additional, OTSUKA, KOJI, additional, HOFFMAN, ROBERT M., additional, and MURAKAMI, MASAHIKO, additional

Published
2021
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45. Use of Transumbilical Incision as an Organ Removal Site in Laparoscopic Pancreatectomy

Author

TOMIOKA, KODAI, primary, MURAKAMI, MASAHIKO, additional, AOKI, TAKESHI, additional, MATSUDA, KAZUHIRO, additional, KOIZUMI, TOMOTAKE, additional, KUSANO, TOMOKAZU, additional, NOGAKI, KOJI, additional, TASHIRO, YOSHIHIKO, additional, WADA, YUSUKE, additional, HAKOZAKI, TOMOKI, additional, SHIBATA, HIDEKI, additional, HIRAI, TAKAHITO, additional, YAMAZAKI, TATSUYA, additional, SAITO, KAZUHIKO, additional, SATO, YOSHIHITO, additional, MOCHIZUKI, KIYOTAKA, additional, FUJIMORI, AKIRA, additional, and ENAMI, YUTA, additional

Published
2021
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46. The Efficacy of Intraoperative Fluorescent Imaging Using Indocyanine Green for Cholangiography During Cholecystectomy and Hepatectomy

Author

Shibata, Hideki, primary, Aoki, Takeshi, additional, Koizumi, Tomotake, additional, Kusano, Tomokazu, additional, Yamazaki, Tatsuya, additional, Saito, Kazuhiko, additional, Hirai, Takahito, additional, Tomioka, Kodai, additional, Wada, Yusuke, additional, Hakozaki, Tomoki, additional, Tashiro, Yoshihiko, additional, Nogaki, Koji, additional, Yamada, Kosuke, additional, Matsuda, Kazuhiro, additional, Fujimori, Akira, additional, Enami, Yuta, additional, and Murakami, Masahiko, additional

Published
2021
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