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223 results on '"Tary-Lehmann, Magdalena"'

1. Anti-drug Antibody Sample Testing and Reporting Harmonization

Author

Jani, Darshana, Marsden, Robin, Gunsior, Michele, Hay, Laura Schild, Ward, Bethany, Cowan, Kyra J., Azadeh, Mitra, Barker, Breann, Cao, Liching, Closson, Kristin R., Coble, Kelly, Dholakiya, Sanjay L., Dusseault, Julie, Hays, Amanda, Herl, Carina, Hodsdon, Michael E., Irvin, Susan C., Kirshner, Susan, Kolaitis, Gerry, Kulagina, Nadia, Kumar, Seema, Lai, Ching Ha, Lipari, Francesco, Liu, Susana, Merdek, Keith D., Moldovan, Ioana R., Mozaffari, Reza, Pan, Luying, Place, Corina, Snoeck, Veerle, Manning, Marta Starcevic, Stocker, Dennis, Tary-Lehmann, Magdalena, Turner, Amy, Vainshtein, Inna, Verthelyi, Daniela, Williams, William T., Yan, Haoheng, Yan, Weili, Yang, Lili, Yang, Lin, Zemo, Jennifer, and Zhong, Zhandong Don

Published
2022
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2. Theoretical and practical considerations for validating antigen-specific B cell ImmunoSpot assays

Author

Lehmann, Paul V., primary, Karulin, Alexey Y., additional, Becza, Noémi, additional, Yao, Lingling, additional, Liu, Zhigang, additional, Chepke, Jack, additional, Maul-Pavicic, Andrea, additional, Wolf, Carla, additional, Köppert, Sebastian, additional, Valente, Alexis V., additional, Gorbachev, Anton V., additional, Tary-Lehmann, Magdalena, additional, and Kirchenbaum, Greg A., additional

Published
2024
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7. Stability of SARS-CoV-2 spike antigens against mutations

Author

De la Fuente, Ildefonso M., primary, Malaina, Iker, additional, Fedetz, Maria, additional, Chruszcz, Maksymilian, additional, Grandes, Gontzal, additional, Targoni, Oleg, additional, Lozano-Pérez, Antonio A., additional, Shteyer, Eyal, additional, Ya’acov, Ami Ben, additional, de la Cámara, Agustín Gómez, additional, Borobia, Alberto M., additional, Carrasco-Pujante, Jose, additional, Pijoan, Jose Ignacio, additional, Bringas, Carlos, additional, Pérez-Yarza, Gorka, additional, Ouro, Alberto, additional, Crawford, Michael J., additional, Shoshan-Barmatz, Varda, additional, Zhurov, Vladimir, additional, López, José I., additional, Knafo, Shira, additional, Tary-Lehmann, Magdalena, additional, Gabaldón, Toni, additional, and Grbic, Miodrag, additional

Published
2022
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8. Stability of SARS-CoV-2 spike antigens against mutations

Author

European Commission, Natural Sciences and Engineering Research Council of Canada, Eusko Jaurlaritza, Universidad del País Vasco, De la Fuente, Ildefonso M. [0000-0001-6548-7583], Malaina, Iker [0000-0002-1305-6623], Carrasco-Pujante, J. [0000-0001-6490-738X], De la Fuente, Ildefonso M., Malaina, Iker, Fedetz, María, Chruszcz, Maksymilian, Grandes, Gontzal, Lozano-Pérez, Antonio A., Shteyer, Eyal, Ya'akov, Ami Ben, Gómez de la Cámara, Agustín, Borobia, Alberto M., Carrasco-Pujante, J., Pijoan, José Ignacio, Bringas, Carlos, Pérez-Yarza, G., Ouro, Alberto, Crawford, Michael J., Shoshan-Barmatz, Varda, Zhurov, Vladimir, López, Jose I., Knafo, Shira, Tary-Lehmann, Magdalena, Gabaldón, Toni, Grbić, Miodrag, European Commission, Natural Sciences and Engineering Research Council of Canada, Eusko Jaurlaritza, Universidad del País Vasco, De la Fuente, Ildefonso M. [0000-0001-6548-7583], Malaina, Iker [0000-0002-1305-6623], Carrasco-Pujante, J. [0000-0001-6490-738X], De la Fuente, Ildefonso M., Malaina, Iker, Fedetz, María, Chruszcz, Maksymilian, Grandes, Gontzal, Lozano-Pérez, Antonio A., Shteyer, Eyal, Ya'akov, Ami Ben, Gómez de la Cámara, Agustín, Borobia, Alberto M., Carrasco-Pujante, J., Pijoan, José Ignacio, Bringas, Carlos, Pérez-Yarza, G., Ouro, Alberto, Crawford, Michael J., Shoshan-Barmatz, Varda, Zhurov, Vladimir, López, Jose I., Knafo, Shira, Tary-Lehmann, Magdalena, Gabaldón, Toni, and Grbić, Miodrag

Abstract

Modern health care needs preventive vaccines and therapeutic treatments with stability against pathogen mutations to cope with current and future viral infections. At the beginning of the COVID-19 pandemic, our analytic and predictive tool identified a set of eight short SARS-CoV-2 S-spike protein epitopes that had the potential to persistently avoid mutation. Here a combination of genetic, Systems Biology and protein structure analyses confirm the stability of our identified epitopes against viral mutations. Remarkably, this research spans the whole period of the pandemic, during which 93.9% of the eight peptides remained invariable in the globally predominant 43 circulating variants, including Omicron. Likewise, the selected epitopes are conserved in 97% of all 1,514 known SARS-CoV-2 lineages. Finally, experimental analyses performed with these short peptides showed their specific immunoreactivity. This work opens a new perspective on the design of next-generation vaccines and antibody therapies that will remain reliable against future pathogen mutations.

Published
2022

11. Safety and Immunogenicity of M2-Deficient, Single Replication, Live Influenza Vaccine (M2SR) in Adults

Author

Eiden, Joseph, primary, Gordon, Gilad, additional, Fierro, Carlos, additional, Herber, Renee, additional, Aitchison, Roger, additional, Belshe, Robert, additional, Greenberg, Harry, additional, Hoft, Daniel, additional, Hatta, Yasuko, additional, Moser, Michael J., additional, Tary-Lehmann, Magdalena, additional, Kawaoka, Yoshihiro, additional, Neumann, Gabriele, additional, Radspinner, Paul, additional, and Bilsel, Pamuk, additional

Published
2021
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24. Human Antibody Responses Following Vaccinia Immunization Using Protein Microarrays and Correlation With Cell-Mediated Immunity and Antibody-Dependent Cellular Cytotoxicity Responses.

Author

Frey, Sharon E, Stapleton, Jack T, Ballas, Zuhair K, Rasmussen, Wendy L, Kaufman, Thomas M, Blevins, Tammy P, Jensen, Travis L, Davies, D Huw, Tary-Lehmann, Magdalena, Chaplin, Paul, Hill, Heather, Goll, Johannes B, Group, DMID 09-0002 MVA Vaccine Study, and DMID 09-0002 MVA Vaccine Study Group

Abstract

Background: There are limited data regarding immunological correlates of protection for the modified vaccinia Ankara (MVA) smallpox vaccine.Methods: A total of 523 vaccinia-naive subjects were randomized to receive 2 vaccine doses, as lyophilized MVA given subcutaneously, liquid MVA given subcutaneously (liquid-SC group), or liquid MVA given intradermally (liquid-ID group) 28 days apart. For a subset of subjects, antibody-dependent cellular cytotoxicity (ADCC), interferon-γ release enzyme-linked immunospot (ELISPOT), and protein microarray antibody-binding assays were conducted. Protein microarray responses were assessed for correlations with plaque reduction neutralization titer (PRNT), enzyme-linked immunosorbent assay, ADCC, and ELISPOT results.Results: MVA elicited significant microarray antibody responses to 15 of 224 antigens, mostly virion membrane proteins, at day 28 or 42, particularly WR113/D8L and WR101H3L. In the liquid-SC group, responses to 9 antigens, including WR113/D8L and WR101/H3L, correlated with PRNT results. Three were correlated in the liquid-ID group. No significant correlations were observed with ELISPOT responses. In the liquid-ID group, WR052/F13L, a membrane glycoprotein, correlated with ADCC responses.Conclusions: MVA elicited antibodies to 15 vaccinia strain antigens representing virion membrane. Antibody responses to 2 proteins strongly increased and significantly correlated with increases in PRNT. Responses to these proteins are potential correlates of protection and may serve as immunogens for future vaccine development.Clinical Trials Registration: NCT00914732. [ABSTRACT FROM AUTHOR]

Published
2021
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30. 1970. Phase 1 Clinical Trial of Intranasal Immunization with M2-Deficient, Single Replication, Live Influenza Vaccine (M2SR): Safety and Immune Response in Adults

Author

Eiden, Joseph, primary, Gordon, Gilad, additional, Fierro, Carlos, additional, Belshe, Robert, additional, Greenberg, Harry, additional, Hoft, Dan, additional, Hatta, Yasuko, additional, Imboden, Michael, additional, Moser, Mike, additional, Herber, Renee, additional, Boltz, David, additional, Tary-Lehmann, Magdalena, additional, Kawaoka, Yoshihiro, additional, Neumann, Gabriele, additional, Radspinner, Paul, additional, Aitchison, Roger, additional, and Bilsel, Pamuk, additional

Published
2018
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34. Involvement of brain-derived neurotrophic factor (BDNF) in MP4-induced autoimmune encephalomyelitis

Author

Javeri, Sita, Rodi, Michael, Tary-Lehmann, Magdalena, Lehmann, Paul V., Addicks, Klaus, Kuerten, Stefanie, Javeri, Sita, Rodi, Michael, Tary-Lehmann, Magdalena, Lehmann, Paul V., Addicks, Klaus, and Kuerten, Stefanie

Abstract

The role of brain-derived neurotrophic factor (BDNF) in multiple sclerosis and experimental autoimmune encephalomyelitis (EAE) is still unclear. Here we investigate the clinical course, CNS histopathology and peripheral antigen-specific immunity in MP4-induced EAE of BDNF (-/+) mice. We demonstrate that these mice displayed less severe disease compared to BDNF (+/+) mice, reflected by decreased inflammation and demyelination. In correspondence to diminished frequencies of T and B cells in CNS infiltrates, the peripheral MP4-specific T(H)1/T(H)17 response was attenuated in BDNF (-/+), but not in wild-type animals. In contrast, immunization with ovalbumin triggered similar frequencies of IFN-gamma- and IL-17-secreting T cells in both groups. The cytokine secretion and proliferative activity upon mitogen stimulation did not reveal any global defect of T cell function in BDNF (-/+) mice. By influencing the antigen-specific immune response in autoimmune encephalomyelitis, BDNF may support and maintain the disease in ways that go beyond its alleged neuroprotective role. (C) 2010 Elsevier Inc. All rights reserved.

Published
2010

35. Safety and immunogenicity of IMVAMUNE® smallpox vaccine using different strategies for a post event scenario

Author

Frey, Sharon E., primary, Winokur, Patricia L., additional, Salata, Robert A., additional, El-Kamary, Samer S., additional, Turley, Christine B., additional, Walter, Emmanuel B., additional, Hay, Christine Mhorag, additional, Newman, Frances K., additional, Hill, Heather R., additional, Zhang, Ying, additional, Chaplin, Paul, additional, Tary-Lehmann, Magdalena, additional, and Belshe, Robert B., additional

Published
2013
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42. Impaired Plasmacytoid Dendritic Cell (PDC)-NK Cell Activity in Viremic Human Immunodeficiency Virus Infection Attributable to Impairments in both PDC and NK Cell Function

Author

Conry, Sara J., primary, Milkovich, Kimberly A., additional, Yonkers, Nicole L., additional, Rodriguez, Benigno, additional, Bernstein, Helene B., additional, Asaad, Robert, additional, Heinzel, Frederick P., additional, Tary-Lehmann, Magdalena, additional, Lederman, Michael M., additional, and Anthony, Donald D., additional

Published
2009
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