11 results on '"Taro Kurosawa"'
Search Results
2. Comparison of the clinical performance and usefulness of five SARS-CoV-2 antibody tests.
- Author
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Mitsuru Wakita, Mayumi Idei, Kaori Saito, Yuki Horiuchi, Kotoko Yamatani, Suzuka Ishikawa, Takamasa Yamamoto, Gene Igawa, Masanobu Hinata, Katsuhiko Kadota, Taro Kurosawa, Sho Takahashi, Takumi Saito, Shigeki Misawa, Chihiro Akazawa, Toshio Naito, Takashi Miida, Kazuhisa Takahashi, Tomohiko Ai, and Yoko Tabe
- Subjects
Medicine ,Science - Abstract
We examined the usefulness of five COVID-19 antibody detection tests using 114 serum samples at various time points from 34 Japanese COVID-19 patients. We examined Elecsys Anti-SARS-CoV-2 from Roche, and four immunochromatography tests from Hangzhou Laihe Biotech, Artron Laboratories, Chil, and Nadal. In the first week after onset, Elecsys had 40% positivity in Group S (severe cases) but was negative in Group M (mild-moderate cases). The immunochromatography kits showed 40-60% and 0-8% positivity in Groups S and M, respectively. In the second week, Elecsys showed 75% and 50% positivity, and the immunochromatography tests showed 5-80% and 50-75% positivity in Groups S and M, respectively. After the third week, Elecsys showed 100% positivity in both groups. The immunochromatography kits showed 100% positivity in Group S. In Group M, positivity decreased to 50% for Chil and 75-89% for Artron and Lyher. Elecsys and immunochromatography kits had 91-100% specificity. Elecsys had comparable chronological change of cut-off index values in the two groups from the second week to the sixth week. The current SARS-CoV-2 antibody detection tests do not provide meaningful interpretation of severity and infection status. Its use might be limited to short-term epidemiological studies.
- Published
- 2021
- Full Text
- View/download PDF
3. Successful Treatment of Steroid-resistant Eosinophilic Gastrointestinal Disease with Mepolizumab.
- Author
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Kentaro Ito, Tomoyoshi Shibuya, Kei Nomura, Mayuko Haraikawa, Taro Kurosawa, Keiichi Haga, Yoichi Akazawa, Takashi Murakami, Osamu Nomura, Mariko Hojo, Takashi Yao, and Akihito Nagahara
- Published
- 2023
- Full Text
- View/download PDF
4. CV2/CRMP5-antibody-related Paraneoplastic Neurologic Syndrome Associated with Gastrointestinal Stromal Tumor
- Author
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Nobuko Serizawa, Tomoyoshi Shibuya, Takashi Murakami, Mariko Hojo, Takahito Awatsu, Takashi Yao, Nobutaka Hattori, Akihito Nagahara, Hirofumi Fukushima, Taro Kurosawa, Akio Mori, and Keiichi Haga
- Subjects
Male ,medicine.medical_specialty ,Gastrointestinal Stromal Tumors ,Paraneoplastic Syndromes ,medicine.medical_treatment ,Gastroenterology ,Serology ,Internal medicine ,Internal Medicine ,Neurological syndrome ,medicine ,Humans ,In patient ,Stromal tumor ,Aged ,Autoantibodies ,Heterogeneous group ,biology ,GiST ,business.industry ,General Medicine ,digestive system diseases ,biology.protein ,Gastrectomy ,Neoplasm Recurrence, Local ,Nervous System Diseases ,Antibody ,business ,Paraneoplastic Syndromes, Nervous System - Abstract
Paraneoplastic neurological syndrome (PNS) is a heterogeneous group of neurological disorders caused by immune-mediated inflammatory mechanisms. We herein report a 77-year-old man with CV2/CRMP5-antibody-related PNS associated with a gastrointestinal stromal tumor (GIST). He was admitted for forgetfulness and delusional behavior. His neurological symptoms were subacute, and a whole-body examination revealed a gastric GIST. Serology showed CV2/collapsin response mediator protein (CRMP)-5 antibodies. Partial gastrectomy was performed for the GIST, and the neurological symptoms and serum CV2/CRMP5 antibodies disappeared. No relapse has occurred since the surgery. PNS should be considered in patients with subacute neurological disorders.
- Published
- 2022
5. Sessile serrated lesions: Clinicopathological characteristics, endoscopic diagnosis, and management
- Author
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Takashi Murakami, Taro Kurosawa, Hirofumi Fukushima, Tomoyoshi Shibuya, Takashi Yao, and Akihito Nagahara
- Subjects
Adenoma ,Hyperplasia ,Gastroenterology ,Colonic Polyps ,Humans ,Microsatellite Instability ,Radiology, Nuclear Medicine and imaging ,Colonoscopy ,Colorectal Neoplasms - Abstract
The 2019 World Health Organization (WHO) Classification of Tumours of the Digestive System (5th edition) introduced the term "sessile serrated lesion" (SSL) to replace the term "sessile serrated adenoma/polyp" (SSA/P). SSLs are early precursor lesions in the serrated neoplasia pathway that result in colorectal carcinomas with BRAF mutations, methylation for DNA repair genes, a CpG island methylator phenotype, and high levels of microsatellite instability. Some of these lesions can rapidly become dysplastic or invasive carcinomas that exhibit high lymphatic invasion and lymph node metastasis potential. The 2019 WHO classification noted that dysplasia arising in an SSL most likely is an advanced polyp, regardless of the morphologic grade of the dysplasia. Detecting SSLs with or without dysplasia is critical; however, detection of SSLs is challenging, and their identification by endoscopists and pathologists is inconsistent. Furthermore, indications for their endoscopic treatment have not been established. Moreover, SSLs are considered to contribute to the development of post-colonoscopy colorectal cancers. Herein, the clinicopathological and endoscopic characteristics of SSLs, including features determined using white light and image-enhanced endoscopy, therapeutic indications, therapeutic methods, and surveillance are reviewed based on the literature. This information may lead to more intensive research to improve detection, diagnosis, and rates of complete resection of these lesions and reduce post-colonoscopy colorectal cancer rates.
- Published
- 2022
6. Linked color imaging improves visibility of colorectal serrated lesion by high color contrast to surrounding mucosa
- Author
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Takashi Murakami, Eiji Kamba, Kei Nomura, Taro Kurosawa, Keiichi Haga, Hirofumi Fukushima, Tsutomu Takeda, Tomoyoshi Shibuya, Takashi Yao, and Akihito Nagahara
- Subjects
Adenoma ,Narrow Band Imaging ,Mucous Membrane ,Gastroenterology ,Humans ,Color ,Colonic Polyps ,Radiology, Nuclear Medicine and imaging ,Colonoscopy ,Colorectal Neoplasms - Abstract
This study aimed to objectively evaluate the efficacy of linked color imaging (LCI) in diagnosing colorectal serrated lesions by utilizing visibility scores and color differences.We examined 89 serrated lesions, including 36 hyperplastic polyps (HPs), 47 sessile serrated lesions (SSLs), and six traditional serrated adenomas (TSAs). Visibility changes were scored by six endoscopists as follows: 4, excellent; 3, good; 2, fair; and 1, poor. Furthermore, images obtained by white-light imaging (WLI) or LCI were assessed using the CIELAB color space in the lesion and adjacent mucosa. We calculated the mean color values (L*, a*, and b*) measured at five regions of interest of the sample lesion and surrounding mucosa and derived the color difference (ΔE*).The visibility scores of both HPs and SSLs in LCI were significantly higher than that in WLI (HPs, 3.67/2.89, P 0.001; SSLs, 3.07/2.36, P 0.001). Furthermore, SSLs showed a significantly higher L* value and significantly lower a* and b* values in LCI than the adjacent mucosae (L*, 61.76/58.23, P = 0.016; a*, 14.91/17.58, P = 0.019; b*, 20.42/24.21, P = 0.007), while WLI produced no significant difference in any color value. A similar trend was apparent in HPs. In all serrated groups, LCI revealed significantly greater ΔE* values between the lesion and adjacent mucosa than WLI (HPs, 11.54/6.12; SSLs, 13.43/7.67; TSAs, 35.00/22.48).Linked color imaging showed higher color contrast between serrated lesions and the surrounding mucosae compared with WLI, indicating improved visibility of colorectal serrated lesion using LCI.
- Published
- 2022
7. Mucin phenotypes and clinicopathological features of colorectal adenocarcinomas: Correlation with colorectal adenocarcinoma with enteroblastic differentiation
- Author
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Taro Kurosawa, Takashi Murakami, Yuya Yamashiro, Hiroyuki Terukina, Takuo Hayashi, Tsuyoshi Saito, Shuko Nojiri, Kazuhiro Sakamoto, Akihito Nagahara, and Takashi Yao
- Subjects
Mucin-2 ,Phenotype ,Mucin-1 ,Humans ,Cell Biology ,Adenocarcinoma ,Colorectal Neoplasms ,Prognosis ,Immunohistochemistry ,Mucin-6 ,Pathology and Forensic Medicine - Abstract
The mucin phenotypes of colorectal carcinoma (CRC) is related to the biological behavior and prognosis. But there has been no studies evaluating phenotypic characteristics in a large number of cases. Furthermore, colorectal adenocarcinoma with enteroblastic differentiation (CAED) is a rare subtype of CRC and having poor prognosis. The aims of this study were to clarify the correlation between mucin phenotypes and tumor development, including biological behavior in CRC, as well as to investigate characteristic of mucin phenotypes in CAED.974 CRC cases and 42 CAED cases of CRCs were classified five types (large-intestinal, small-intestinal, gastric, mixed, and unclassified) of mucin phenotypes by using immunohistochemistry (IHC). IHC was performed on tissue microarrays with antibodies against followings: MUC2, MUC5AC, MUC6, and CD10. In CRCs, large-intestine type has a relatively better prognosis, small-intestinal type frequently shows venous invasions, and liver metastases, gastric type has more high-histological grades and lymphatic invasions, mixed type shows originating from the right side of the colon, larger tumor size and mucinous type, but less venous invasions and liver metastasis, whereas the unclassified type showed poorer prognosis in overall survival with statistical significance. The majority of CAED were found to be small-intestinal type or unclassified type.The phenotypic classification is useful for predicting the prognosis of CRCs. Small-intestinal type and unclassified type showed dismal prognosis in CRCs. We speculate that CAED having aggressive behavior and poor prognosis might reflect characteristics of small-intestinal and unclassified types.
- Published
- 2021
8. CV2/CRMP5-antibody-related Paraneoplastic Neurologic Syndrome Associated with Gastrointestinal Stromal Tumor.
- Author
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Hirofumi Fukushima, Tomoyoshi Shibuya, Takahito Awatsu, Taro Kurosawa, Keiichi Haga, Takashi Murakami, Nobuko Serizawa, Akio Mori, Mariko Hojo, Takashi Yao, Nobutaka Hattori, and Akihito Nagahara
- Published
- 2022
- Full Text
- View/download PDF
9. A case of rectal neuroendocrine tumor (NET) without recurrence for 5 years after endoscopic submucosal dissection (ESD)
- Author
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Hiroyuki Isayama, Hirofumi Fukushima, Takashi Yao, Naoto Sakamoto, Taro Kurosawa, Kenichi Ikejima, Kenshi Matsumoto, Shuichiro Shina, Shotaro Oki, Hiroya Ueyama, Takashi Murakami, Tomoyoshi Shibuya, and Akihito Nagahara
- Subjects
medicine.medical_specialty ,business.industry ,Mechanical Engineering ,medicine ,Energy Engineering and Power Technology ,Endoscopic submucosal dissection ,Radiology ,Management Science and Operations Research ,business - Published
- 2019
10. Comparison of the clinical performance and usefulness of five SARS-CoV-2 antibody tests
- Author
-
Toshio Naito, Mayumi Idei, Kazuhisa Takahashi, Shigeki Misawa, Katsuhiko Kadota, Yoko Tabe, Chihiro Akazawa, Sho Takahashi, Kaori Saito, Kotoko Yamatani, Gene Igawa, Takumi Saito, Taro Kurosawa, Yuki Horiuchi, Masanobu Hinata, Tomohiko Ai, Takashi Miida, Suzuka Ishikawa, Mitsuru Wakita, and Takamasa Yamamoto
- Subjects
Male ,RNA viruses ,0301 basic medicine ,Viral Diseases ,Coronaviruses ,Physiology ,Artificial Gene Amplification and Extension ,Antibodies, Viral ,Biochemistry ,Polymerase Chain Reaction ,Gastroenterology ,Serology ,Medical Conditions ,0302 clinical medicine ,Immune Physiology ,Medicine and Health Sciences ,030212 general & internal medicine ,Enzyme-Linked Immunoassays ,Pathology and laboratory medicine ,Virus Testing ,Immune System Proteins ,Multidisciplinary ,biology ,Clinical performance ,Middle Aged ,Medical microbiology ,Chemistry ,Infectious Diseases ,Viruses ,Physical Sciences ,Medicine ,Female ,SARS CoV 2 ,Pathogens ,Antibody ,Research Article ,Chemical Elements ,Antibody detection ,Adult ,medicine.medical_specialty ,2019-20 coronavirus outbreak ,SARS coronavirus ,Coronavirus disease 2019 (COVID-19) ,Science ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Immunology ,Research and Analysis Methods ,Sensitivity and Specificity ,Microbiology ,Antibodies ,COVID-19 Serological Testing ,03 medical and health sciences ,Diagnostic Medicine ,Internal medicine ,medicine ,Humans ,Immunoassays ,Molecular Biology Techniques ,Molecular Biology ,Aged ,Biology and life sciences ,SARS-CoV-2 ,business.industry ,Organisms ,Viral pathogens ,COVID-19 ,Proteins ,Covid 19 ,Reverse Transcriptase-Polymerase Chain Reaction ,Serum samples ,Microbial pathogens ,Oxygen ,030104 developmental biology ,Immunologic Techniques ,biology.protein ,Reagent Kits, Diagnostic ,business - Abstract
We examined the usefulness of five COVID-19 antibody detection tests using 114 serum samples at various time points from 34 Japanese COVID-19 patients. We examined Elecsys Anti-SARS-CoV-2 from Roche, and four immunochromatography tests from Hangzhou Laihe Biotech, Artron Laboratories, Chil, and Nadal. In the first week after onset, Elecsys had 40% positivity in Group S (severe cases) but was negative in Group M (mild-moderate cases). The immunochromatography kits showed 40–60% and 0–8% positivity in Groups S and M, respectively. In the second week, Elecsys showed 75% and 50% positivity, and the immunochromatography tests showed 5–80% and 50–75% positivity in Groups S and M, respectively. After the third week, Elecsys showed 100% positivity in both groups. The immunochromatography kits showed 100% positivity in Group S. In Group M, positivity decreased to 50% for Chil and 75–89% for Artron and Lyher. Elecsys and immunochromatography kits had 91–100% specificity. Elecsys had comparable chronological change of cut-off index values in the two groups from the second week to the sixth week. The current SARS-CoV-2 antibody detection tests do not provide meaningful interpretation of severity and infection status. Its use might be limited to short-term epidemiological studies.
- Published
- 2021
11. A Case of Early Colonic Cancer with a Diameter of 6mm and Synchronous Liver Metastasis
- Author
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Tomoyoshi Shibuya, Takashi Yao, Akihito Nagahara, Kenichi Ikejima, Junko Kato, Yuzuru Tajima, Hideaki Ritsuno, Hiroya Ueyama, Naoto Sakamoto, Kentaro Izumi, Taro Kurosawa, Kenshi Matsumoto, Takashi Murakami, and Hiromichi Isayama
- Subjects
Colonic cancer ,business.industry ,Mechanical Engineering ,Cancer research ,Energy Engineering and Power Technology ,Medicine ,Management Science and Operations Research ,business ,medicine.disease ,Metastasis - Published
- 2019
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