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Objectives: Cardiotrophin-1 (CT-1) is closely linked to many cardiovascular diseases, such as myocardial infarction and heart failure, and exhibits cardioprotective effect in ischemia-reperfusion injury. The present study was designed to investigate the course of CT-1 in patients undergoing on-pump coronary artery bypass grafting (CABG), and to evaluate the relationship between plasma CT-1 levels and postoperative cardiac function.Methods: Twenty-four patients undergoing elective CABG were studied. Radial artery blood samples were collected before cardiopulmonary bypass (CPB), 5 min and 20 min after reperfusion, and 1 h, 6 h, 12 h and 24 h after CPB. Coronary sinus blood samples were collected before CPB, 5 min and 20 min after reperfusion. Plasma CT-1 levels were measured using the ELISA method. Hemodynamic data were collected.Results: Peripheral CT-1 levels did not change significantly postoperatively. Trans-myocardial CT-1 levels increased significantly 5 min and 20 minutes after reperfusion as compared to baseline. A weak positive correlation (r = 0.408, p = 0.048) was found between trans-myocardial CT-1 levels at 20 min after reperfusion and CI at 12 h after CPB.Conclusions: The heart secretes CT-1 after ischemic injury. The precise effect of CT-1 in CABG needs further investigation. [ABSTRACT FROM AUTHOR]

Aims. To compare mothers' and fathers' parenting satisfaction; to identify factors contributing to their parenting satisfaction; and to evaluate the effect of these factors.Background. Parenting satisfaction is important for parents' motivation to care, nurture and interact with their child. Parenting is influenced by attributes of parent, infant and the environment. However, more research is needed to understand the contributing factors.Design. Parenting satisfaction and several parent, infant and environment attributes were measured at hospital or in one week of discharge. A total of 2600 questionnaires were handed out to a convenience sample of Finnish speaking parents in two hospitals during the winter of 2006. Multiple-birth and early-discharge parents receiving support at home were excluded. Responses were received from 863 mothers (66%) and 525 fathers (40%).Methods. Comparisons were made by percentages and means. Significances were determined by GEE models and One Way ANOVA tests. Pearson's and Spearman's correlations were used to determine correlations and multiple regression analysis to clarify the effect size.Results. Mothers were more satisfied than fathers with their parenting. Self-concept, depressive symptoms, infant centrality, state of mind on discharge and perception of infant contributed most to parenting satisfaction. Family functioning, health and advice from personnel were major contributory factors as well.Conclusion. Hospital practices and social support from personnel did not correlate with parenting satisfaction. More research is recommended to evaluate them, since they had an effect when combined with other attributes.Relevance to clinical practice. Our results will help professionals understand the experiences, resources and challenges faced by parents. Family-oriented care and sound advice have the potential to offer the most supportive environment for both parents. If professionals can identify mothers who are afraid, concerned or insecure during pregnancy, they can also offer them extra support before the child is born. [ABSTRACT FROM AUTHOR]

Aim. This paper is a report of study of parent, infant and environmental correlates of mothers' and fathers' perceptions of their parenting self-efficacy. Background. Many parents are not confident in their ability to be good parents. Parenting self-efficacy is important for parents' sense of well-being, is a possible predictor of parenting practices and might be an indicator of risk. However, very little evidence exists on factors that influence fathers' perceptions of parenting, or comparisons between the parents. Methods. The data were collected by questionnaire in 2006-2007 in two hospitals with a convenience sample of Finnish-speaking parents (N = 1300 families) during the first postpartum week. Multiple-birth and early-discharge parents were excluded. The response rate for mothers was 66% (n = 863) and for fathers 40% (n = 525). Comparisons were made by percentages and means. Statistical significance was determined by Generalized Estimating Equations models and one-way anova. Pearson's and Spearman's correlation coefficients were used to determine correlations, and multiple regression analysis to clarify the effect size. Results. Mothers scored higher than fathers on parenting self-efficacy. Parity, self-concept, depressive symptoms and state of mind on discharge contributed to parenting self-efficacy. Experiences of childbirth and life change correlated with mothers', but not with fathers', parenting self-efficacy. Perceptions of infant, family functioning, health and advice from personnel were major contributory factors. Conclusion. Assessments of parenting self-efficacy are recommended to identify at-risk groups and at-risk parents. More research is recommended to look into the effect of rooming-in, feeding practices, fathers' presence and social support from personnel and parenting self-efficacy and to evaluate risk scales for at-risk parents. Parent attributes had a greater effect on mothers' parenting self-efficacy, while environmental attributes had a greater effect on fathers' parenting self-efficacy. At-risk parents can be supported by conducting face-to-face discussions about significant topics. [ABSTRACT FROM AUTHOR]