1. Liquid biopsies for residual disease and recurrence
- Author
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Jonathan Chee Ming Wan, Tariq Imdadali Mughal, Pedram Razavi, Sarah-Jane Dawson, Esther Louise Moss, Ramaswamy Govindan, Iain Beehuat Tan, Yoon-Sim Yap, William Allen Robinson, Clive Dylan Morris, Benjamin Besse, Alberto Bardelli, Jeanne Tie, Scott Kopetz, and Nitzan Rosenfeld
- Subjects
clinical trials ,Neoplasm, Residual ,Liquid Biopsy ,residual disease and recurrence ,ctDNA ,General Medicine ,solid tumors ,Circulating Tumor DNA ,MRD ,RDR ,Biomarkers, Tumor ,Humans ,Neoplasm Recurrence, Local - Abstract
Detection of minimal residual disease in patients with cancer, who are in complete remission with no cancer cells detectable, has the potential to improve recurrence-free survival through treatment selection. Studies analyzing circulating tumor DNA (ctDNA) in patients with solid tumors suggest the potential to accurately predict and detect relapse, enabling treatment strategies that may improve clinical outcomes. Over the past decade, assays for ctDNA detection in plasma samples have steadily increased in sensitivity and specificity. These are applied for the detection of residual disease after treatment and for earlier detection of recurrence. Novel clinical trials are now assessing how assays for "residual disease and recurrence" (RDR) may influence current treatment paradigms and potentially change the landscape of risk classification for cancer recurrence. In this review, we appraise the progress of RDR detection using ctDNA and consider the emerging role of liquid biopsy in the monitoring and management of solid tumors.
- Published
- 2021