1. Predictors and outcomes of linezolid-resistant vancomycin-resistant Enterococcus: A case-case-control study
- Author
-
Kayoko Hayakawa, Gayathri Vadlamudi, Paul R. Lephart, Rida Mroue, Priyanka Nanjireddy, Tarek Obeid, Aaisha Chaudhry, Emily T. Martin, Dror Marchaim, Kavyashri Jagadeesh, Shakila Parveen, Jason M. Pogue, Michael J. Rybak, Bharath Sunkara, Keith S. Kaye, Manit Singla, Kevin Ho, Mohamad Farhat, Sarah Bommarito, and Judy Moshos
- Subjects
Adult ,Male ,medicine.medical_specialty ,Epidemiology ,medicine.drug_class ,medicine.medical_treatment ,Antibiotics ,medicine.disease_cause ,chemistry.chemical_compound ,Antibiotic resistance ,Risk Factors ,Vancomycin ,Internal medicine ,Acetamides ,Drug Resistance, Bacterial ,polycyclic compounds ,medicine ,Humans ,heterocyclic compounds ,Vancomycin-resistant Enterococcus ,Intensive care medicine ,Gram-Positive Bacterial Infections ,Oxazolidinones ,Aged ,Aged, 80 and over ,biology ,business.industry ,Health Policy ,Linezolid ,Public Health, Environmental and Occupational Health ,Case-control study ,Immunosuppression ,Middle Aged ,biochemical phenomena, metabolism, and nutrition ,bacterial infections and mycoses ,biology.organism_classification ,Multiple drug resistance ,Treatment Outcome ,Infectious Diseases ,Enterococcus ,chemistry ,Case-Control Studies ,bacteria ,Female ,business - Abstract
Linezolid is an important agent for the treatment of infections because of vancomycin-resistant Enterococcus (VRE). This study identified independent predictors for isolation of linezolid-resistant VRE (LZD-R-VRE) and analyzed outcomes associated with linezolid resistance. Immunosuppression, prior surgery, and previous exposure to β-lactam antibiotics were independent predictors for isolation of LZD-R-VRE but not for LZD-susceptible-VRE. Prior exposure to linezolid was not a predictor for isolation of LZD-R-VRE.
- Published
- 2012
- Full Text
- View/download PDF