707 results on '"Tarallo, A. P."'
Search Results
2. First Report of Colletotrichum fioriniae and Colletotrichum godetiae causing anthracnose disease of Blueberry (Vaccinium corymbosum L.) Fruit in New Zealand
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Hosking, Jack E., Mesarich, Carl H., Tarallo, Mariana, de la Rosa, Silvia, and Rivera, Sebastian A.
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- 2024
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Catalog
3. Long-term outcomes and trends in elbow arthroplasty with Coonrad-Morrey prosthesis: a retrospective study in large group of patients
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Tarallo, Luigi, Celli, Andrea, Delvecchio, Matilde, Costabile, Lorenzo, Ciacca, Grazia, Porcellini, Giuseppe, and Catani, Fabio
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- 2024
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4. Analysis of spin-squeezing generation in cavity-coupled atomic ensembles with continuous measurements
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Caprotti, A., Barbiero, M., Tarallo, M. G., Genoni, M. G., and Bertaina, G.
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Quantum Physics ,Physics - Atomic Physics - Abstract
We analyze the generation of spin-squeezed states via coupling of three-level atoms to an optical cavity and continuous quantum measurement of the transmitted cavity field in order to monitor the evolution of the atomic ensemble. Using analytical treatment and microscopic simulations of the dynamics, we show that one can achieve significant spin squeezing, favorably scaling with the number of atoms $N$. However, contrary to some previous literature, we clarify that it is not possible to obtain Heisenberg scaling without the continuous feedback that is proposed in optimal approaches. In fact, in the adiabatic cavity removal approximation and large $N$ limit, we find the scaling behavior $N^{-2/3}$ for spin squeezing and $N^{-1/3}$ for the corresponding protocol duration. These results can be obtained only by considering the curvature of the Bloch sphere, since linearizing the collective spin operators tangentially to its equator yields inaccurate predictions. With full simulations, we characterize how spin-squeezing generation depends on the system parameters and departs from the bad cavity regime, by gradually mixing with cavity-filling dynamics until metrological advantage is lost. Finally, we discuss the relevance of this spin-squeezing protocol to state-of-the-art optical clocks., Comment: 30 pages, 9 figures, post-print version more...
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- 2023
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5. Multidisciplinary high resolution Geophysical Imaging of Pantano Ripa Rossa Segment of the Irpinia Fault (Southern Italy)
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Bruno, Pier Paolo G., Ferrara, Giuseppe, Zambrano, Miller, Maraio, Stefano, Improta, Luigi, Volatili, Tiziano, Di Fiore, Vincenzo, Florio, Giovanni, Iacopini, David, Accomando, Filippo, Tarallo, Daniela, De Martini, Paolo Marco, Muccini, Filippo, Punzo, Michele, Paoletti, Valeria, Albanese, Stefano, Iannone, Antonio, Pacifico, Lucia Rita, Vicari, Annamaria, Famiglietti, Nicola Angelo, Memmolo, Antonino, Cavuoto, Giuseppe, and Milano, Maurizio more...
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- 2024
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6. The European reference network for metabolic diseases (MetabERN) clinical pathway recommendations for Pompe disease (acid maltase deficiency, glycogen storage disease type II)
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Parenti, Giancarlo, Fecarotta, Simona, Alagia, Marianna, Attaianese, Federica, Verde, Alessandra, Tarallo, Antonietta, Gragnaniello, Vincenza, Ziagaki, Athanasia, Guimaraes, Maria Jose’, Aguiar, Patricio, Hahn, Andreas, Azevedo, Olga, Donati, Maria Alice, Kiec-Wilk, Beata, Scarpa, Maurizio, van der Beek, Nadine A. M. E., Del Toro Riera, Mireja, Germain, Dominique P., Huidekoper, Hidde, van den Hout, Johanna M. P., and van der Ploeg, Ans T. more...
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- 2024
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7. Assessing semantic interoperability in environmental sciences: variety of approaches and semantic artefacts
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Di Muri, Cristina, Pulieri, Martina, Raho, Davide, Muresan, Alexandra N., Tarallo, Andrea, Titocci, Jessica, Nestola, Enrica, Basset, Alberto, Mazzoni, Sabrina, and Rosati, Ilaria
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- 2024
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8. Essential gene screening identifies the bromodomain-containing protein BRPF1 as a new actionable target for endocrine therapy-resistant breast cancers
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Salvati, Annamaria, Giurato, Giorgio, Lamberti, Jessica, Terenzi, Ilaria, Crescenzo, Laura, Melone, Viola, Palo, Luigi, Giordano, Alessandro, Sabbatino, Francesco, Roscigno, Giuseppina, Quintavalle, Cristina, Condorelli, Gerolama, Rizzo, Francesca, Tarallo, Roberta, Nassa, Giovanni, and Weisz, Alessandro more...
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- 2024
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9. Genomic and culture-based analysis of Cyclaneusma minus in New Zealand provides evidence for multiple morphotypes
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Tarallo, Mariana, Dobbie, Kiryn Barbara, Leite, Luciano Nunes, Waters, Tammy Leigh, Gillard, Kristin Nikki Tasmin, Sen, Diya, Mesarich, Carl Hayden, Bradshaw, Rosie Ellen, and McDougal, Rebecca Louise more...
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- 2024
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10. Small non-coding RNA transcriptomic profiling in adult and fetal human brain
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Smal, Marharyta, Memoli, Domenico, Alexandrova, Elena, Di Rosa, Domenico, D’Agostino, Ylenia, Russo, Fabio, Giurato, Giorgio, Nassa, Giovanni, Tarallo, Roberta, Weisz, Alessandro, and Rizzo, Francesca more...
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- 2024
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11. Exploring the gut DNA virome in fecal immunochemical test stool samples reveals associations with lifestyle in a large population-based study
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Istvan, Paula, Birkeland, Einar, Avershina, Ekaterina, Kværner, Ane S., Bemanian, Vahid, Pardini, Barbara, Tarallo, Sonia, de Vos, Willem M., Rognes, Torbjørn, Berstad, Paula, and Rounge, Trine B.
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- 2024
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12. Small noncoding RNAs and sperm nuclear basic proteins reflect the environmental impact on germ cells
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Ferrero, Giulio, Festa, Rosaria, Follia, Laura, Lettieri, Gennaro, Tarallo, Sonia, Notari, Tiziana, Giarra, Antonella, Marinaro, Carmela, Pardini, Barbara, Marano, Alessandra, Piaggeschi, Giulia, Di Battista, Carla, Trifuoggi, Marco, Piscopo, Marina, Montano, Luigi, and Naccarati, Alessio more...
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- 2024
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13. Mitofusin 1 silencing decreases the senescent associated secretory phenotype, promotes immune cell recruitment and delays melanoma tumor growth after chemotherapy
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Tarallo, Doménica, Martínez, Jennyfer, Leyva, Alejandro, Mónaco, Amy, Perroni, Carolina, Tassano, Marcos, Gambini, Juan Pablo, Cappetta, Mónica, Durán, Rosario, Moreno, María, and Quijano, Celia
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- 2024
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14. Multidisciplinary high resolution Geophysical Imaging of Pantano Ripa Rossa Segment of the Irpinia Fault (Southern Italy)
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Pier Paolo G. Bruno, Giuseppe Ferrara, Miller Zambrano, Stefano Maraio, Luigi Improta, Tiziano Volatili, Vincenzo Di Fiore, Giovanni Florio, David Iacopini, Filippo Accomando, Daniela Tarallo, Paolo Marco De Martini, Filippo Muccini, Michele Punzo, Valeria Paoletti, Stefano Albanese, Antonio Iannone, Lucia Rita Pacifico, Annamaria Vicari, Nicola Angelo Famiglietti, Antonino Memmolo, Giuseppe Cavuoto, and Maurizio Milano more...
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Medicine ,Science - Abstract
Abstract The Irpinia Fault, also known as the Monte Marzano Fault System, located in the Southern Apennines (Italy), is one of the most seismically active structures in the Mediterranean. It is the source of the 1980, Ms 6.9, multi-segment rupture earthquake that caused significant damage and nearly 3,000 casualties. Paleoseismological surveys indicate that this structure has generated at least four Mw ~ 7 surface-rupturing earthquakes in the past 2 ka. This paper presents a comprehensive, high-resolution geophysical investigation focused on the southernmost fault segment of the Monte Marzano Fault System, i.e., the Pantano-Ripa Rossa Fault, outcropping within the Pantano di San Gregorio Magno intramontane basin. The project, named TEst Site IRpinia fAult (TESIRA), was supported by the University of Napoli Federico II to study the near-surface structure of this intra-basin fault splay that repeatedly ruptured co-seismically in the past thousands of years. Our imaging approach included 2D and 3D electrical and seismic surveys, gravimetry, 3D FullWaver electrical tomography, drone-borne GPR and magnetic surveys, and CO2 soil flux assessment across the surface rupture. This multidisciplinary investigation improved our understanding of the basin shallow structure, providing an image of a rather complex subsurface fault and basin geometry. Seismic data suggest that fault activity at the Pantano segment of MMFS is characterized by a near-surface cumulative displacement greater than previous estimations, calling into question earlier assumptions about the timing of its activation. Despite some challenges with our drone-mounted survey equipment, the integrated dataset provides a comprehensive and reliable image of the subsurface structure. This work demonstrates the utility of developing an integrated approach at high-resolution geophysical imaging and interpretation of fault zones with weak morphological expressions. more...
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- 2024
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15. The European reference network for metabolic diseases (MetabERN) clinical pathway recommendations for Pompe disease (acid maltase deficiency, glycogen storage disease type II)
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Giancarlo Parenti, Simona Fecarotta, Marianna Alagia, Federica Attaianese, Alessandra Verde, Antonietta Tarallo, Vincenza Gragnaniello, Athanasia Ziagaki, Maria Jose’ Guimaraes, Patricio Aguiar, Andreas Hahn, Olga Azevedo, Maria Alice Donati, Beata Kiec-Wilk, Maurizio Scarpa, Nadine A. M. E. van der Beek, Mireja Del Toro Riera, Dominique P. Germain, Hidde Huidekoper, Johanna M. P. van den Hout, Ans T. van der Ploeg, and and the MetabERN Subnetwork for Lysosomal Disorders more...
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Pompe disease ,Glycogen storage disease (GSD) type II ,Acid alpha-glucosidase deficiency ,Acid maltase deficiency ,Lysosomal storage disease ,Medicine - Abstract
Abstract Clinical pathway recommendations (CPR) are based on existing guidelines and deliver a short overview on how to deal with a specific diagnosis, resulting therapy and follow-up. In this paper we propose a methodology for developing CPRs for Pompe disease, a metabolic myopathy caused by deficiency of lysosomal acid alpha-glucosidase. The CPR document was developed within the activities of the MetabERN, a non-profit European Reference Network for Metabolic Diseases established by the European Union. A working group was selected among members of the MetabERN lysosomal storage disease subnetwork, with specific expertise in the care of Pompe disease, and patient support group representatives. The working strategy was based on a systematic literature search to develop a database, followed by quality assessment of the studies selected from the literature, and by the development of the CPR document according to a matrix provided by MetabERN. Quality assessment of the literature and collection of citations was conducted according to the AGREE II criteria and Grading of Recommendations, Assessment, Development and Evaluation methodology. General aspects were addressed in the document, including pathophysiology, genetics, frequency, classification, manifestations and clinical approach, laboratory diagnosis and multidisciplinary evaluation, therapy and supportive measures, follow-up, monitoring, and pregnancy. The CPR document that was developed was intended to be a concise and easy-to-use tool for standardization of care for patients among the healthcare providers that are members of the network or are involved in the care for Pompe disease patients. more...
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- 2024
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16. Assessing semantic interoperability in environmental sciences: variety of approaches and semantic artefacts
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Cristina Di Muri, Martina Pulieri, Davide Raho, Alexandra N. Muresan, Andrea Tarallo, Jessica Titocci, Enrica Nestola, Alberto Basset, Sabrina Mazzoni, and Ilaria Rosati
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Science - Abstract
Abstract The integration and reuse of digital research products can be only ensured through the adoption of machine-actionable (meta)data standards enriched with semantic artefacts. This study compiles 540 semantic artefacts in environmental sciences to: i. examine their coverage in scientific domains and topics; ii. assess key aspects of their FAIRness; and iii. evaluate management and governance concerns. The analyses showed that the majority of semantic artefacts concern the terrestrial biosphere domain, and that a small portion of the total failed to meet the FAIR principles. For example, 5.5% of semantic artefacts were not available in semantic catalogues, 8% were not built with standard model languages and formats, 24.6% were published without usage licences and 22.4% without version information or with divergent versions across catalogues in which they were available. This investigation discusses common semantic practices, outlines existing gaps and suggests potential solutions to address semantic interoperability challenges in some of the resources originally designed to guarantee it. more...
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- 2024
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17. Comparing endoscopic and conventional surgery techniques for carpal tunnel syndrome: A retrospective study
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Danilo Donati, Chiara Goretti, Roberto Tedeschi, Paolo Boccolari, Vincenzo Ricci, Giacomo Farì, Fabio Vita, and Luigi Tarallo
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Carpal tunnel syndrome (CTS) ,Endoscopic carpal tunnel release (ECTR) ,Open carpal tunnel release (OCTR) ,Functional recovery ,Hand surgery ,Surgery ,RD1-811 - Abstract
Introduction: This study aimed to compare the effectiveness of endoscopic carpal tunnel release (ECTR) versus open carpal tunnel release (OCTR) in treating carpal tunnel syndrome (CTS), focusing on symptom relief, functional recovery and post-operative complications. Methods: A retrospective analysis was conducted on 44 patients diagnosed with CTS, randomly assigned to undergo either ECTR (n=23) or OCTR (n=21). Parameters evaluated included post-operative pain, grip strength, functional status using the Disability of the Arm, Shoulder and Hand (DASH) score and time to return to work. Results: Patients who underwent ECTR demonstrated superior functional recovery and quicker return to daily and work activities compared to those in the OCTR group. Grip strength improvement post-surgery showed no significant difference between the groups. However, ECTR patients reported significantly lower DASH scores and faster return to work, indicating better outcomes. There were fewer reports of post-operative complications and scar sensitivity in the ECTR group. Conclusion: ECTR provides an effective alternative to OCTR for CTS treatment, with advantages in functional recovery speed, reduced post-operative discomfort and faster return to work. These findings support the adoption of ECTR as a preferred surgical approach for CTS, highlighting its potential to improve patient outcomes with minimal complications. more...
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- 2024
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18. Essential gene screening identifies the bromodomain-containing protein BRPF1 as a new actionable target for endocrine therapy-resistant breast cancers
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Annamaria Salvati, Giorgio Giurato, Jessica Lamberti, Ilaria Terenzi, Laura Crescenzo, Viola Melone, Luigi Palo, Alessandro Giordano, Francesco Sabbatino, Giuseppina Roscigno, Cristina Quintavalle, Gerolama Condorelli, Francesca Rizzo, Roberta Tarallo, Giovanni Nassa, and Alessandro Weisz more...
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Breast cancer ,Estrogen signaling ,BRPF1 ,Endocrine therapy resistance ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Identifying master epigenetic factors controlling proliferation and survival of cancer cells allows to discover new molecular targets exploitable to overcome resistance to current pharmacological regimens. In breast cancer (BC), resistance to endocrine therapy (ET) arises from aberrant Estrogen Receptor alpha (ERα) signaling caused by genetic and epigenetic events still mainly unknown. Targeting key upstream components of the ERα pathway provides a way to interfere with estrogen signaling in cancer cells independently from any other downstream event. By combining computational analysis of genome-wide ‘drop-out’ screenings with siRNA-mediated gene knock-down (kd), we identified a set of essential genes in luminal-like, ERα + BC that includes BRPF1, encoding a bromodomain-containing protein belonging to a family of epigenetic readers that act as chromatin remodelers to control gene transcription. To gather mechanistic insights into the role of BRPF1 in BC and ERα signaling, we applied chromatin and transcriptome profiling, gene ablation and targeted pharmacological inhibition coupled to cellular and functional assays. Results indicate that BRPF1 associates with ERα onto BC cell chromatin and its blockade inhibits cell cycle progression, reduces cell proliferation and mediates transcriptome changes through the modulation of chromatin accessibility. This effect is elicited by a widespread inhibition of estrogen signaling, consequent to ERα gene silencing, in antiestrogen (AE) -sensitive and -resistant BC cells and pre-clinical patient-derived models (PDOs). Characterization of the functional interplay of BRPF1 with ERα reveals a new regulator of estrogen-responsive BC cell survival and suggests that this epigenetic factor is a potential new target for treatment of these tumors. more...
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- 2024
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19. Ambassadors of professional development in teaching and learning in STEM higher education
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Brouwer Natasa, Niemelä Matti, Maciejowska Iwona, Grecea Ştefania, Tarallo Oreste, and Russo Vincenzo
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continuous professional development (cpd) ,teaching competences ,higher education ,stem ,Chemistry ,QD1-999 - Abstract
In STEM higher education, lecturers need to assist learners in constructing understanding of complex scientific concepts by employing relevant teaching methods, tools, and technologies. A continuous professional development (CPD) of academic teaching staff in teaching and learning is indispensable to keep up with the development of STEM. Using a cascade-like approach in continuous professional development in teaching and learning, where lecturers are involved bottom-up as CPD-Ambassadors, makes it possible to address relevant STEM-specific teaching and learning issues and continuously improve teaching practice. At three international STEM-CPD Summer Schools for CPD-Ambassadors, the CPD-Ambassadors developed fifty CPD-User cases about organising professional development in teaching and learning at their own higher education institutions and promoting the importance of CPD in their local context. The analysis of the CPD-User cases shows that the most frequently addressed teaching competencies and attitudes foster student-centred teaching approaches based on constructivist educational views. A relationship is found with previously defined generally important teaching competences and attitudes for higher STEM education. The results indicate that a cascade-like, discipline oriented continuous professional development approach through CPD-Ambassadors is a promising approach in improving university teaching practice. more...
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- 2024
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20. Genomic and culture-based analysis of Cyclaneusma minus in New Zealand provides evidence for multiple morphotypes
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Mariana Tarallo, Kiryn Barbara Dobbie, Luciano Nunes Leite, Tammy Leigh Waters, Kristin Nikki Tasmin Gillard, Diya Sen, Carl Hayden Mesarich, Rosie Ellen Bradshaw, and Rebecca Louise McDougal
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Cyclaneusma minus ,Morphotypes ,Cyclaneusma needle cast ,Genome sequencing ,Ecp32 candidate effector family ,Plant culture ,SB1-1110 - Abstract
Abstract Cyclaneusma needle cast, caused by Cyclaneusma minus, affects Pinus species world wide. Previous studies suggested the presence of two distinct morphotypes in New Zealand, ‘verum’ and ‘simile’. Traditional mycological analyses revealed a third morphotype with clear differences in colony morphology and cardinal growth rates at varying temperatures. Genome sequencing of eight C. minus isolates provided further evidence of the existence of a third morphotype, named as ‘novus’ in this study. To further analyse these morphotypes, we predicted candidate effector proteins for all eight isolates, and also characterized a cell-death eliciting effector family, Ecp32, which is present in other pine phytopathogens. In concordance with their distinct classification into three different morphotypes, the number of Ecp32 family members differed, with patterns of pseudogenization in the ‘simile’ morphotype, and some members being found exclusively either in the ‘simile’ or ‘verum’ morphotypes. We also showed that the Ecp32 family proteins trigger cell death in non-host Nicotiana species, and, as previously demonstrated in other plant pathogens, the Ecp32 family proteins in C. minus adopt a β-trefoil fold. These analyses provide further evidence that the three morphotypes might be distinct species that need formal descriptions. Understanding the geographical range of different Cyclaneusma species and variations in virulence and pathogenicity will provide a better understanding of pine needle diseases and enable the development of more durable methods to control this disease. more...
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- 2024
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21. Small non-coding RNA transcriptomic profiling in adult and fetal human brain
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Marharyta Smal, Domenico Memoli, Elena Alexandrova, Domenico Di Rosa, Ylenia D’Agostino, Fabio Russo, Giorgio Giurato, Giovanni Nassa, Roberta Tarallo, Alessandro Weisz, and Francesca Rizzo
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Science - Abstract
Abstract Small non-coding RNAs (sncRNAs) make up ~1% of the transcriptome; nevertheless, they play significant roles in regulating cellular processes. Given the complexity of the central nervous system, sncRNAs likely hold particular importance in the human brain. In this study, we provide sncRNA transcriptomic profiles in a range of adult and prenatal brain regions, with a focus on piRNAs, due to their underexplored expression in somatic cells and tissue-specific nature. Using the WIND workflow, which combines two detection methods, we found 1333 (731 miRNAs, 249 piRNAs, 285 snoRNAs, and 68 other sncRNAs) and 1445 unique sncRNAs (770 miRNAs, 307 piRNAs, 289 snoRNAs, and 79 other sncRNAs) in developing and adult brains, respectively. Significant variations were found upon comparison of fetal and adult brain groups, with 82 miRNAs, 17 piRNAs, and 70 snoRNAs enriched in fetal brains and 22 miRNAs, 11 piRNAs in adult brains. This dataset represents a valuable resource for exploring the sncRNA roles in brain function, their involvement in neurological diseases, and the molecular mechanisms behind brain region interactions. more...
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- 2024
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22. Progettare e sperimentare a scuola attraverso il DIST-M: opportunità didattiche e riflessioni
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Anna Coen, Andrea Cravotta, Piera Romano, and Chiara Tarallo
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storytelling ,digital storytelling ,didattica della matematica ,apprendimento collaborativo ,gioco di ruolo ,piattaforma Moodle ,Education ,Mathematics ,QA1-939 - Abstract
La richiesta di progettare e sperimentare un’attività con la metodologia del Digital Interactive Storytelling in Matematica (DIST-M) durante un corso di formazione per docenti in servizio si è rivelata un’efficace opportunità di sviluppo professionale. Vengono qui presentate le riflessioni degli autori in merito alle ricadute e alle potenzialità di una sperimentazione didattica attuata secondo il quadro teorico e il protocollo del DIST-M, in riferimento alla progettazione per competenze, all’interazione tramite Moodle, che offre la possibilità di esaminare le discussioni di classe attraverso la trascrizione delle chat, e alla modalità immersiva dello storytelling, che ha richiesto a docenti e studenti di agire impersonando personaggi con ruoli predefiniti, alternando le modalità di attore e di osservatore. In particolare, viene evidenziato come la metodologia del DIST-M possa diventare utile strumento di valutazione formativa degli studenti, nonché occasione di autovalutazione per docenti e studenti riflessivi. more...
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- 2024
23. Beyond the genomes of Fulvia fulva (syn. Cladosporium fulvum) and Dothistroma septosporum: New insights into how these fungal pathogens interact with their host plants
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Mesarich, Carl H, Barnes, Irene, Bradley, Ellie L, Rosa, Silvia, Wit, Pierre JGM, Guo, Yanan, Griffiths, Scott A, Hamelin, Richard C, Joosten, Matthieu HAJ, Lu, Mengmeng, McCarthy, Hannah M, Schol, Christiaan R, Stergiopoulos, Ioannis, Tarallo, Mariana, Zaccaron, Alex Z, and Bradshaw, Rosie E more...
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Microbiology ,Plant Biology ,Biological Sciences ,Prevention ,2.2 Factors relating to the physical environment ,Aetiology ,Infection ,Ascomycota ,Cladosporium ,Pinus ,Genome ,Fungal ,Host Microbial Interactions ,Dothistroma needle blight ,effector proteins ,genome sequences ,host susceptibility and resistance ,pathogen diversity ,secondary metabolites ,tomato leaf mould ,Crop and Pasture Production ,Plant Biology & Botany ,Evolutionary biology ,Plant biology - Abstract
Fulvia fulva and Dothistroma septosporum are closely related apoplastic pathogens with similar lifestyles but different hosts: F. fulva is a pathogen of tomato, whilst D. septosporum is a pathogen of pine trees. In 2012, the first genome sequences of these pathogens were published, with F. fulva and D. septosporum having highly fragmented and near-complete assemblies, respectively. Since then, significant advances have been made in unravelling their genome architectures. For instance, the genome of F. fulva has now been assembled into 14 chromosomes, 13 of which have synteny with the 14 chromosomes of D. septosporum, suggesting these pathogens are even more closely related than originally thought. Considerable advances have also been made in the identification and functional characterization of virulence factors (e.g., effector proteins and secondary metabolites) from these pathogens, thereby providing new insights into how they promote host colonization or activate plant defence responses. For example, it has now been established that effector proteins from both F. fulva and D. septosporum interact with cell-surface immune receptors and co-receptors to activate the plant immune system. Progress has also been made in understanding how F. fulva and D. septosporum have evolved with their host plants, whilst intensive research into pandemics of Dothistroma needle blight in the Northern Hemisphere has shed light on the origins, migration, and genetic diversity of the global D. septosporum population. In this review, we specifically summarize advances made in our understanding of the F. fulva-tomato and D. septosporum-pine pathosystems over the last 10 years. more...
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- 2023
24. Quantum Monte Carlo study of the role of p-wave interactions in ultracold repulsive Fermi gases
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Bertaina, Gianluca, Tarallo, Marco G., and Pilati, Sebastiano
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Condensed Matter - Quantum Gases ,Physics - Atomic Physics ,Quantum Physics - Abstract
Single-component ultracold atomic Fermi gases are usually described using noninteracting many-fermion models. However, recent experiments reached a regime where $p$-wave interactions among identical fermionic atoms are important. In this paper, we employ variational and fixed-node diffusion Monte Carlo simulations to investigate the ground-state properties of single-component Fermi gases with short-range repulsive interactions. We determine the zero-temperature equation of state, and elucidate the roles played by the $p$-wave scattering volume and the $p$-wave effective range. A comparison against recently derived second-order perturbative results shows good agreement in a broad range of interaction strength. We also compute the quasiparticle effective mass, and we confirm the perturbative prediction of a linear contribution in the $p$-wave scattering volume, while we find significant deviations from the beyond-mean-field perturbative result, already for moderate interaction strengths. Finally, we determine ground-state energies for two-component unpolarized Fermi gases with both interspecies and intraspecies hard-sphere interactions, finding remarkable agreement with a recently derived fourth-order expansion that includes $p$-wave contributions., Comment: 9 pages, 4 figures. Extended data for the effective mass and changed title. Post-print version more...
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- 2022
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25. Cancer-derived exosomal Alu RNA promotes colorectal cancer progression
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Magliacane Trotta, Sara, Adinolfi, Antonio, D’Orsi, Luca, Panico, Sonia, Mercadante, Grazia, Mehlen, Patrick, Ambati, Jayakrishna, De Falco, Sandro, and Tarallo, Valeria
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- 2024
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26. Great tuberosity fixation does not affect healing and clinical outcomes in RSA performed in proximal humeral fractures in elderly patients
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Porcellini, Giuseppe, Montanari, Marta, Giorgini, Andrea, Micheloni, Gian Mario, Bonfatti, Rocco, and Tarallo, Luigi
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- 2024
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27. MicroRNA dysregulation in ataxia telangiectasia
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Emilia Cirillo, Antonietta Tarallo, Elisabetta Toriello, Annamaria Carissimo, Giuliana Giardino, Antonio De Rosa, Carla Damiano, Annarosa Soresina, Raffaele Badolato, Rosa Maria Dellepiane, Lucia A. Baselli, Maria Carrabba, Giovanna Fabio, Patrizia Bertolini, Davide Montin, Francesca Conti, Roberta Romano, Elisa Pozzi, Giulio Ferrero, Roberta Roncarati, Manuela Ferracin, Alfredo Brusco, Giancarlo Parenti, and Claudio Pignata more...
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ataxia telangiectasia ,microRNA ,immunodeficiency ,cancer ,DNA repair ,Immunologic diseases. Allergy ,RC581-607 - Abstract
IntroductionAtaxia telangiectasia (AT) is a rare disorder characterized by neurodegeneration, combined immunodeficiency, a predisposition to malignancies, and high clinical variability. Profiling of microRNAs (miRNAs) may offer insights into the underlying mechanisms of complex rare human diseases, as miRNAs play a role in various biological functions including proliferation, differentiation, and DNA repair. In this study, we investigate the differential expression of miRNAs in samples from AT patients to identify miRNA patterns and analyze how these patterns are related to the disease.MethodsWe enrolled 20 AT patients (mean age 17.7 ± 9.6 years old) and collected clinical and genetic data. We performed short non-coding RNA-seq analysis on peripheral blood mononuclear cells (PBMCs) and fibroblasts to compare the miRNA expression profile between AT patients and controls.ResultsWe observed 42 differentially expressed (DE)-miRNAs in blood samples and 26 in fibroblast samples. Among these, three DE-miRNAs, miR-342-3p, miR-30a-5p, and miR-195-5p, were further validated in additional AT samples, confirming their dysregulation.DiscussionWe identified an AT-related miRNA signature in blood cells and fibroblast samples collected from a group of AT patients. We also predicted several dysregulated pathways, primarily related to cancer, immune system control, or inflammatory processes. The findings suggest that miRNAs may provide insights into the pathophysiology and tumorigenesis of AT and have the potential to serve as useful biomarkers in cancer research. more...
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- 2024
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28. EFFECTS OF TREADMILL GAIT TRAINING ON BALANCE IN PARKINSON’S PATIENTS AFTER DEEP BRAIN STIMULATION
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Viviane Carolina Sales de Andrade, Angelica Castilho Alonso, Natalia Mariana Silva Luna, Fernanda Botta Tarallo Rogatto, Guilherme Carlos Brech, Danilo Sales Bocalini, and Júlia Maria D’Andrea Greve
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Parkinson Disease ,Deep Brain Stimulation ,Postural Balance ,Neurological Gait Disorders ,Neurological Rehabilitation ,Medicine ,Orthopedic surgery ,RD701-811 - Abstract
ABSTRACT Objective: After deep brain stimulation (DBS), patients with Parkinson’s disease (PD) typically still present significant gait and postural stability problems, and thus additional interventions are needed. In this way, our purpose was evaluate the comparative effectiveness of treadmill training, with and without body weight support, on balance outcomes among patients with PD after DBS. Methods: Eleven patients with PD that were using bilateral subthalamic nucleus DBS were evaluated using Time Up and Go test (TUG); Berg Balance Scale (BBS) and Static Posturography. In phase 1, all subjects participated in 8-weeks of treadmill training in conjunction with conventional physiotherapy. After six weeks (wash-out), each patient then participated in a subsequent 8-weeks of treadmill training with partial body weight support. Results: After the phase 1, there were improvements on the cognitive TUG performance (Before: 15.7 ± 1,8 sec; After: 13.7 ± 3.1 sec; p < 0.01) and an increase of anteroposterior and medio-lateral body oscillation with eyes closed. After the phase 2, there were improvements in conventional (Before: 12.3 ± 2.0 sec; After: 10.7 ± 1.7 sec; p < 0.01) and cognitive (Before: 14.6 ± 3.5 sec; After: 12.5 ± 1.6 sec; p < 0.05) TUG performances. There were no significant changes in the Berg Balance Scale following either training protocol. Conclusion: Both trainings improved static and dynamic balance and had similar results; however, supported treadmill training seemed to be a potentially superior option, as patients tended to feel safer. Level of Evidence II, therapeutic studies - investigation of treatment outcomes. more...
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- 2024
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29. One-Dimensional Disordered Bosonic Systems
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D'Errico, Chiara and Tarallo, Marco G.
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Condensed Matter - Disordered Systems and Neural Networks ,Condensed Matter - Quantum Gases - Abstract
Disorder is everywhere in nature and it has a fundamental impact on the behavior of many quantum systems. The presence of a small amount of disorder, in fact, can dramatically change the coherence and transport properties of a system. Despite the growing interest in this topic, a complete understanding of the issue is still missing. An open question, for example, is the description of the interplay of disorder and interactions, which has been predicted to give rise to exotic states of matter such as quantum glasses or many-body localization. In this review, we will present an overview of experimental observations with disordered quantum gases, focused on one-dimensional bosons, and we will connect them with theoretical predictions., Comment: Review paper; 11 pages, 9 figures more...
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- 2022
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30. Cancer-derived exosomal Alu RNA promotes colorectal cancer progression
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Sara Magliacane Trotta, Antonio Adinolfi, Luca D’Orsi, Sonia Panico, Grazia Mercadante, Patrick Mehlen, Jayakrishna Ambati, Sandro De Falco, and Valeria Tarallo
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Medicine ,Biochemistry ,QD415-436 - Abstract
Abstract Inflammation plays a crucial role in cancer progression, but the relevance of the inflammasome remains unclear. Alu RNA was the first endogenous nucleic acid shown to activate the NLRP3 (nucleotide-binding domain leucine-rich repeat containing 3) inflammasome. Here, we showed that Alu RNA can induce epithelial-to-mesenchymal transition (EMT) through NLRP3 inflammasome activation and IL-1β release in colorectal cancer (CRC) cells. Alu RNA is stored, transported and transferred to CRC cells by exosomes. Exosomal Alu RNA promotes tumorigenesis by inducing invasion, metastasis and EMT via NLRP3 inflammasome activation. Consistent with these data, we found that significantly increased Alu RNA expression correlates with the induction of NLRP3 priming in human CRC patients. Furthermore, the level of Alu RNA in circulating exosomes correlates with CRC progression in a preclinical model. These findings reveal the direct involvement of Alu RNA in cancer pathogenesis, and its presence in CRC cell-derived exosomes could be used as a noninvasive diagnostic biomarker. more...
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- 2024
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31. Exploring the gut DNA virome in fecal immunochemical test stool samples reveals associations with lifestyle in a large population-based study
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Paula Istvan, Einar Birkeland, Ekaterina Avershina, Ane S. Kværner, Vahid Bemanian, Barbara Pardini, Sonia Tarallo, Willem M. de Vos, Torbjørn Rognes, Paula Berstad, and Trine B. Rounge
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Science - Abstract
Abstract Stool samples for fecal immunochemical tests (FIT) are collected in large numbers worldwide as part of colorectal cancer screening programs. Employing FIT samples from 1034 CRCbiome participants, recruited from a Norwegian colorectal cancer screening study, we identify, annotate and characterize more than 18000 DNA viruses, using shotgun metagenome sequencing. Only six percent of them are assigned to a known taxonomic family, with Microviridae being the most prevalent viral family. Linking individual profiles to comprehensive lifestyle and demographic data shows 17/25 of the variables to be associated with the gut virome. Physical activity, smoking, and dietary fiber consumption exhibit strong and consistent associations with both diversity and relative abundance of individual viruses, as well as with enrichment for auxiliary metabolic genes. We demonstrate the suitability of FIT samples for virome analysis, opening an opportunity for large-scale studies of this enigmatic part of the gut microbiome. The diverse viral populations and their connections to the individual lifestyle uncovered herein paves the way for further exploration of the role of the gut virome in health and disease. more...
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- 2024
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32. Small noncoding RNAs and sperm nuclear basic proteins reflect the environmental impact on germ cells
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Giulio Ferrero, Rosaria Festa, Laura Follia, Gennaro Lettieri, Sonia Tarallo, Tiziana Notari, Antonella Giarra, Carmela Marinaro, Barbara Pardini, Alessandra Marano, Giulia Piaggeschi, Carla Di Battista, Marco Trifuoggi, Marina Piscopo, Luigi Montano, and Alessio Naccarati more...
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Environmental pollution ,Male fertility ,Small noncoding RNA ,Sperm nuclear basic proteins ,Transcriptomics ,Therapeutics. Pharmacology ,RM1-950 ,Biochemistry ,QD415-436 - Abstract
Abstract Background Molecular techniques can complement conventional spermiogram analyses to provide new information on the fertilizing potential of spermatozoa and to identify early alterations due to environmental pollution. Methods Here, we present a multilevel molecular profiling by small RNA sequencing and sperm nuclear basic protein analysis of male germ cells from 33 healthy young subjects residing in low and high-polluted areas. Results Although sperm motility and sperm concentration were comparable between samples from the two sites, those from the high-pollution area had a higher concentration of immature/immune cells, a lower protamine/histone ratio, a reduced ability of sperm nuclear basic proteins to protect DNA from oxidative damage, and an altered copper/zinc ratio in sperm. Sperm levels of 32 microRNAs involved in intraflagellar transport, oxidative stress response, and spermatogenesis were different between the two areas. In parallel, a decrease of Piwi-interacting RNA levels was observed in samples from the high-polluted area. Conclusions This comprehensive analysis provides new insights into pollution-driven epigenetic alterations in sperm not detectable by spermiogram. Graphical Abstract more...
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- 2024
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33. Mitofusin 1 silencing decreases the senescent associated secretory phenotype, promotes immune cell recruitment and delays melanoma tumor growth after chemotherapy
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Doménica Tarallo, Jennyfer Martínez, Alejandro Leyva, Amy Mónaco, Carolina Perroni, Marcos Tassano, Juan Pablo Gambini, Mónica Cappetta, Rosario Durán, María Moreno, and Celia Quijano
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Medicine ,Science - Abstract
Abstract Cellular senescence is a therapy endpoint in melanoma, and the senescence-associated secretory phenotype (SASP) can affect tumor growth and microenvironment, influencing treatment outcomes. Metabolic interventions can modulate the SASP, and mitochondrial energy metabolism supports resistance to therapy in melanoma. In a previous report we showed that senescence, induced by the DNA methylating agent temozolomide, increased the level of fusion proteins mitofusin 1 and 2 in melanoma, and silencing Mfn1 or Mfn2 expression reduced interleukin-6 secretion by senescent cells. Here we expanded these observations evaluating the secretome of senescent melanoma cells using shotgun proteomics, and explored the impact of silencing Mfn1 on the SASP. A significant increase in proteins reported to reduce the immune response towards the tumor was found in the media of senescent cells. The secretion of several of these immunomodulatory proteins was affected by Mfn1 silencing, among them was galectin-9. In agreement, tumors lacking mitofusin 1 responded better to treatment with the methylating agent dacarbazine, tumor size was reduced and a higher immune cell infiltration was detected in the tumor. Our results highlight mitochondrial dynamic proteins as potential pharmacological targets to modulate the SASP in the context of melanoma treatment. more...
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- 2024
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34. Cold Atoms in Space: Community Workshop Summary and Proposed Road-Map
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Alonso, Ivan, Alpigiani, Cristiano, Altschul, Brett, Araujo, Henrique, Arduini, Gianluigi, Arlt, Jan, Badurina, Leonardo, Balaz, Antun, Bandarupally, Satvika, Barone, Barry C Barish Michele, Barsanti, Michele, Bass, Steven, Bassi, Angelo, Battelier, Baptiste, Baynham, Charles F. A., Beaufils, Quentin, Belic, Aleksandar, Berge, Joel, Bernabeu, Jose, Bertoldi, Andrea, Bingham, Robert, Bize, Sebastien, Blas, Diego, Bongs, Kai, Bouyer, Philippe, Braitenberg, Carla, Brand, Christian, Braxmaier, Claus, Bresson, Alexandre, Buchmueller, Oliver, Budker, Dmitry, Bugalho, Luıs, Burdin, Sergey, Callegari, Luigi Cacciapuoti Simone, Calmet, Xavier, Calonico, Davide, Canuel, Benjamin, Caramete, Laurentiu-Ioan, Carraz, Olivier, Cassettari, Donatella, Chakraborty, Pratik, Chattopadhyay, Swapan, Chauhan, Upasna, Chen, Xuzong, Chen, Yu-Ao, Chiofalo, Maria Luisa, Coleman, Jonathon, Corgier, Robin, Cotter, J. P., Cruise, A. Michael, Cui, Yanou, Davies, Gavin, De Roeck, Albert, Demarteau, Marcel, Derevianko, Andrei, Di Clemente, Marco, Djordjevic, Goran S., Donadi, Sandro, Dore, Olivier, Dornan, Peter, Doser, Michael, Drougakis, Giannis, Dunningham, Jacob, Easo, Sajan, Eby, Joshua, Elertas, Gedminas, Ellis, John, Evans, David, Examilioti, Pandora, Fadeev, Pavel, Fanı, Mattia, Fassi, Farida, Fattori, Marco, Fedderke, Michael A., Felea, Daniel, Feng, Chen-Hao, Ferreras, Jorge, Flack, Robert, Flambaum, Victor V., Forsberg, Rene, Fromhold, Mark, Gaaloul, Naceur, Garraway, Barry M., Georgousi, Maria, Geraci, Andrew, Gibble, Kurt, Gibson, Valerie, Gill, Patrick, Giudice, Gian F., Goldwin, Jon, Gould, Oliver, Grachov, Oleg, Graham, Peter W., Grasso, Dario, Griffin, Paul F., Guerlin, Christine, Gundogan, Mustafa, Gupta, Ratnesh K, Haehnelt, Martin, Hanımeli, Ekim T., Hawkins, Leonie, Hees, Aurelien, Henderson, Victoria A., Herr, Waldemar, Herrmann, Sven, Hird, Thomas, Hobson, Richard, Hock, Vincent, Hogan, Jason M., Holst, Bodil, Holynski, Michael, Israelsson, Ulf, Jeglic, Peter, Jetzer, Philippe, Juzeliunas, Gediminas, Kaltenbaek, Rainer, Kamenik, Jernej F., Kehagias, Alex, Kirova, Teodora, Kiss-Toth, Marton, Koke, Sebastian, Kolkowitz, Shimon, Kornakov, Georgy, Kovachy, Tim, Krutzik, Markus, Kumar, Mukesh, Kumar, Pradeep, Lammerzahl, Claus, Landsberg, Greg, Poncin-Lafitte, Christophe Le, Leibrandt, David R., Leveque, Thomas, Lewicki, Marek, Li, Rui, Lipniacka, Anna, Liu, Christian Lisdat Mia, Lopez-Gonzalez, J. L., Loriani, Sina, Louko, Jorma, Luciano, Giuseppe Gaetano, Lundblad, Nathan, Maddox, Steve, Mahmoud, M. A., Maleknejad, Azadeh, March-Russell, John, Massonnet, Didier, McCabe, Christopher, Meister, Matthias, Meznarsic, Tadej, Micalizio, Salvatore, Migliaccio, Federica, Millington, Peter, Milosevic, Milan, Mitchell, Jeremiah, Morley, Gavin W., Muller, Jurgen, Murphy, Eamonn, Mustecaplıoglu, Ozgur E., OShea, Val, Oi, Daniel K. L., Olson, Judith, Pal, Debapriya, Papazoglou, Dimitris G., Pasatembou, Elizabeth, Paternostro, Mauro, Pawlowski, Krzysztof, Pelucchi, Emanuele, Santos, Franck Pereira dos, Peters, Achim, Pikovski, Igor, Pilaftsis, Apostolos, Pinto, Alexandra, Prevedelli, Marco, Puthiya-Veettil, Vishnupriya, Quenby, John, Rafelski, Johann, Rasel, Ernst M., Ravensbergen, Cornelis, Reguzzoni, Mirko, Richaud, Andrea, Riou, Isabelle, Rothacher, Markus, Roura, Albert, Ruschhaupt, Andreas, Sabulsky, Dylan O., Safronova, Marianna, Saltas, Ippocratis D., Salvi, Leonardo, Sameed, Muhammed, Saurabh, Pandey, Schaffer, Stefan, Schiller, Stephan, Schilling, Manuel, Schkolnik, Vladimir, Schlippert, Dennis, Schmidt, Piet O., Schnatz, Harald, Schneider, Jean, Schneider, Ulrich, Schreck, Florian, Schubert, Christian, Shayeghi, Armin, Sherrill, Nathaniel, Shipsey, Ian, Signorini, Carla, Singh, Rajeev, Singh, Yeshpal, Skordis, Constantinos, Smerzi, Augusto, Sopuerta, Carlos F., Sorrentino, Fiodor, Sphicas, Paraskevas, Stadnik, Yevgeny V., Stefanescu, Petruta, Tarallo, Marco G., Tentindo, Silvia, Tino, Guglielmo M., Tinsley, Jonathan N., Tornatore, Vincenza, Treutlein, Philipp, Trombettoni, Andrea, Tsai, Yu-Dai, Tuckey, Philip, Uchida, Melissa A, Valenzuela, Tristan, Bossche, Mathias Van Den, Vaskonen, Ville, Verma, Gunjan, Vetrano, Flavio, Vogt, Christian, von Klitzing, Wolf, Waller, Pierre, Walser, Reinhold, Williams, Eric Wille Jason, Windpassinger, Patrick, Wittrock, Ulric, Wolf, Peter, Woltmann, Marian, Worner, Lisa, Xuereb, Andre, Yahia, Mohamed, Yazgan, Efe, Yu, Nan, Zahzam, Nassim, Cruzeiro, Emmanuel Zambrini, Zhan, Mingsheng, Zou, Xinhao, Zupan, Jure, and Zupanic, Erik more...
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Astrophysics - Instrumentation and Methods for Astrophysics ,General Relativity and Quantum Cosmology ,High Energy Physics - Experiment ,High Energy Physics - Phenomenology ,Physics - Atomic Physics - Abstract
We summarize the discussions at a virtual Community Workshop on Cold Atoms in Space concerning the status of cold atom technologies, the prospective scientific and societal opportunities offered by their deployment in space, and the developments needed before cold atoms could be operated in space. The cold atom technologies discussed include atomic clocks, quantum gravimeters and accelerometers, and atom interferometers. Prospective applications include metrology, geodesy and measurement of terrestrial mass change due to, e.g., climate change, and fundamental science experiments such as tests of the equivalence principle, searches for dark matter, measurements of gravitational waves and tests of quantum mechanics. We review the current status of cold atom technologies and outline the requirements for their space qualification, including the development paths and the corresponding technical milestones, and identifying possible pathfinder missions to pave the way for missions to exploit the full potential of cold atoms in space. Finally, we present a first draft of a possible road-map for achieving these goals, that we propose for discussion by the interested cold atom, Earth Observation, fundamental physics and other prospective scientific user communities, together with ESA and national space and research funding agencies., Comment: Summary of the Community Workshop on Cold Atoms in Space and corresponding Road-map: https://indico.cern.ch/event/1064855/ more...
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- 2022
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35. Rebuilding Stability: Exploring the Best Rehabilitation Methods for Chronic Ankle Instability
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Roberto Tedeschi, Vincenzo Ricci, Domiziano Tarantino, Luigi Tarallo, Fabio Catani, and Danilo Donati
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chronic ankle instability ,balance training ,proprioception ,rehabilitation ,functional recovery ,Sports ,GV557-1198.995 - Abstract
Background: Chronic Ankle Instability (CAI) is a common condition characterized by repeated episodes of ankle “giving way” and impaired balance, leading to functional limitations. Various rehabilitation techniques, including balance training, proprioceptive exercises, whole-body vibration (WBV), and novel approaches like stroboscopic vision, are used to address these deficits. This review evaluates the effectiveness of different rehabilitation interventions for CAI management. Methods: A review was conducted by analyzing 11 randomized controlled trials that investigated the impact of balance and proprioceptive training programs on CAI. The primary outcomes assessed were the Star Excursion Balance Test (SEBT), Cumberland Ankle Instability Tool (CAIT), and Foot and Ankle Ability Measure (FAAM). Methodological quality was assessed using the PEDro scale, and the risk of bias was evaluated with the ROB 2 tool. Results: All rehabilitation interventions demonstrated significant improvements in SEBT, CAIT, and FAAM scores. However, no single intervention was found to be consistently superior. Traditional balance training, strength exercises, BAPS, and WBV all provided meaningful functional gains. Stroboscopic vision training showed similar effectiveness compared to conventional approaches. The evidence supports a combination of balance and strength training for optimal recovery. Conclusions: Balance and proprioceptive exercises are effective in managing CAI, with improvements in both dynamic stability and subjective outcomes. No intervention stands out as the best, but personalized programs incorporating various methods are recommended. Future research should explore the long-term effects and potential synergies of combined interventions. more...
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- 2024
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36. The Influence of Pelvic Tilt and Femoral Torsion on Hip Biomechanics: Implications for Clinical Assessment and Treatment
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Danilo Donati, Federica Giorgi, Giacomo Farì, Luigi Tarallo, Fabio Catani, and Roberto Tedeschi
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pelvic tilt ,hip biomechanics ,gait analysis ,compensatory mechanisms ,regional interdependence ,Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Biology (General) ,QH301-705.5 ,Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
Background: Hip biomechanics are crucial in understanding movement disorders and joint pathologies. Pelvic tilt and femoral torsion are key factors influencing hip function and stability. This review aims to elucidate their effects on acetabular orientation, hip range of motion (ROM), and associated compensatory mechanisms. Methods: A comprehensive search of databases, including PubMed, Scopus, and Pedro, was conducted. Studies were selected based on Population, Concept, and Context (PCC) criteria, focusing on those examining the relationship between pelvic tilt, femoral torsion, and hip biomechanics. Eight studies were included, utilizing methodologies such as CT imaging, musculoskeletal modeling, and gait analysis, covering populations ranging from asymptomatic adults to elderly women with pelvic retroversion. Results: The review identified significant effects of pelvic retroversion on acetabular anteversion and hip extension. Some studies found no correlation between pelvic index (PI) and acetabular orientation, while others reported a linear increase in acetabular anteversion with pelvic retroversion. Subjects with pelvic retroversion showed greater hip extension. Additionally, femoral anteversion was linked to increased internal rotation and altered hip joint contact forces during gait, with changes in hip ROM and force distribution. No relationship was found between femoral and acetabular anteversion in patients with hip osteoarthritis. Conclusions: Pelvic tilt and femoral torsion significantly affect hip biomechanics, influencing acetabular orientation, ROM, and compensatory mechanisms. Future studies should include symptomatic populations to explore these relationships further. These findings emphasize the critical need for individualized clinical assessments and further research on symptomatic populations to enhance our understanding of pelvic tilt and femoral torsion’s impact on hip biomechanics. more...
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- 2024
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37. The Relationships between Freshmen's Accuracy of Self-Evaluation and the Likelihood of Succeeding in Chemistry and Physics Exams in Two STEM Undergraduate Courses
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Testa, Italo, Galano, Silvia, and Tarallo, Oreste
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In this longitudinal study, we investigate how demographic, cognitive and meta-cognitive variables affect students' success in chemistry and physics exams in two Science-Technology-Engineering-Mathematics undergraduate courses, biology and engineering. Independent variables include high school final examination performance, chemistry and physics marks, self-efficacy and accuracy of self-evaluation, namely the difference between the estimation of one's own performance in a specific task measured with a confidence rating scale and the actual performance score. We involved 81 biology and 125 engineering freshmen students in the study. Biology students were attending a General Chemistry course, while Engineering students were attending a General Physics course. Accuracy of self-evaluation scores were calculated through Rasch analysis of responses to an instrument that included chemistry and physics items, and a confidence tier. We found that for both courses, the likelihood of passing the exams of chemistry and physics was significantly predicted solely by their accuracy of self-evaluation accuracy score. We found the overconfident students had lower likelihood of passing the exam. Our results suggest that the perception of one's own ability is a relevant factor for predicting students' success at undergraduate level and can be a better predictor of academic success than high school performance and self-efficacy. more...
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- 2023
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38. Endorsement of Gender Stereotypes Affects High School Students' Science Identity
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Galano, Silvia, Liccardo, Antonella, Amodeo, Anna Lisa, Crispino, Marianna, Tarallo, Oreste, and Testa, Italo
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We investigated how the endorsement of gender stereotypes affects disciplinary identity across three different science-technology-engineering-mathematics (STEM) areas: physics, biology, and chemistry, and whether such relationship is mediated by self-concept constructs, such as self-efficacy and perceived academic control. Building on the ambivalent sexism theory and masculine ideology paradigm, we focused on gender stereotypes based on hostile and benevolent sexism and on male role norms. A sample of 1406 Italian high school students (girls = 742) was involved in the study. Structural equation modeling was used to test the hypothesized relationships. Results show that the adherence to male role norms and the rejection of hostile sexism have a significant effect on the development of a disciplinary identity in the three targeted STEM domains. However, such an effect is fully mediated by self-efficacy and perceived academic control. Moreover, the identity in the three addressed STEM domains is differently affected by the endorsement of stereotypes, with physics and biology being more largely affected than chemistry. More importantly, the endorsement of hostile sexism stereotypes significantly decreases the perceived self-efficacy, while higher levels of perceived academic control are predicted by higher levels of endorsement of male role norms, for both girls and boys. Our findings suggest that to reduce the perception of femininity as incongruent with STEM identification, it would be necessary to deconstruct the masculine view of self-efficacy and academic control. more...
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- 2023
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39. Optically loaded Strontium lattice clock with a single multi-wavelength reference cavity
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Barbiero, Matteo, Calonico, Davide, Levi, Filippo, and Tarallo, Marco G.
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Physics - Atomic Physics ,Physics - Instrumentation and Detectors - Abstract
We report on the realization of a new compact strontium optical clock using a 2-D magneto-optical-trap (2D-MOT) as cold atomic source and a multi-wavelength cavity as the frequency stabilization system. All needed optical frequencies are stabilized to a zero-thermal expansion high-finesse optical resonator and can be operated without frequency adjustments for weeks. We present the complete characterization of the apparatus. Optical control of the atomic source allows us to perform low-noise clock operation without atomic signal normalization. Long- and short-term stability tests of the clock have been performed for the 88 Sr bosonic isotope by means of interleaved clock operation. Finally, we present the first preliminary accuracy budget of the system. more...
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- 2021
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40. Reverse shoulder arthroplasty in obstetric brachial plexus injury: our experience with shoulder motion analysis
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Giuseppe Porcellini, Marco Montemagno, Chiara Manzini, Gabriele Fiumana, Andrea Giorgini, Gianmario Micheloni, and Luigi Tarallo
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Obstetric brachial plexus palsy ,Erb palsy ,Reverse shoulder arthroplasty ,Shoulder motion analysis ,Orthopedic surgery ,RD701-811 - Abstract
Abstract Background Obstetric brachial plexus injury (OBPI) is a weakening or paralysis of the upper arm caused by brachial plexus injury followed by a muscle paralysis with severe repercussions on the movement of the shoulder joint following a progressive glenohumeral joint deformity. This case series analyzes the clinical and radiological outcomes of reverse total shoulder arthroplasty (RSA) in OBPI patients with a follow-up of 2 years. Materials and methods OBPI patients with secondary end-stage glenohumeral arthritis were enrolled in the study and they were treated with RSA. Patient demographics and clinical outcomes [Range of Motion (ROM), Visual Analog Scale (VAS), Oxford Shoulder Score (OSS)] were evaluated. A novel Shoulder motion analysis was carried out to investigate specific movement patterns of scapulothoracic movements in these patients. This study is a prospective cohort study. Results Four Patients (M: F = 1:3) were enrolled in the study, the mean age was 49.3 years (+ 2.75), the mean OSS (Oxford Shoulder Score) decreased from 48.8 (± 2.5) preoperatively to 18.30 (± 2.78), the mean VAS (Visual Analog Scale) decreased from 7.25 (± 0.5) to 1.7 (± 0.3) in the follow up (∆% relative pain reduction:− 76.5%), Shoulder ROM obtained an improvement (p more...
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- 2023
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41. Geophysical assessment of seawater intrusion: the Volturno Coastal Plain case study
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D. Tarallo, I. Alberico, G. Cavuoto, N. Pelosi, M. Punzo, and V. Di Fiore
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2D-ERT ,MASW ,Downhole ,Boreholes ,GIS analysis ,Integrated approach ,Water supply for domestic and industrial purposes ,TD201-500 - Abstract
Abstract In coastal alluvial plains, the variability of sedimentary inputs, tectonic and eustatism causes a complex subsurface geology which influences the position of fresh/saltwater interface. Furthermore, in these areas densely populated, the over-pumping of freshwater, coupled with the climate change events, promotes the landward migration of freshwater/saltwater boundary. This research illustrates the ability of geophysical tools to recognize the presence of salt/brackish water at Volturno Coastal Plain, Southern Italy. This area is characterized by a peculiar geological setting, due to the proximity at Somma–Vesuvio and Campi Flegrei volcanic areas, which profoundly influences the circulation of groundwater. The subsurface is mainly characterized by: (i) two denser layers located at − 10 m and − 20 m depth which in part prevents the vertical migration of groundwater, (ii) facies heteropy that facilitates the hydraulic connection between the different geological bodies, (iii) a discontinuous Campanian Ignimbrite deposits which favor the hydraulic connection between deeper and shallower aquifers. In this geological framework, 2D-ERT and 3D-ERT integrated with Downhole, Multichannel Analysis of Surface Waves and boreholes made possible to recognize the presence of two main zones with salt and brackish waters, respectively. The first zone, characterized by very low resistivity (≤ 1 Ωm) typical of salt water, stretches 1.5 km inland from the coast. The second zone, with a resistivity between 2 and 5 Ωm typical of brackish water, continues for other 3 km inland. This knowledge is useful for the engagement of all stakeholders (farmers, ranchers and policy makers) in the sustainable use of fresh water and for making water management plan operational tools. more...
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- 2023
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42. Efficacy of two diode lasers in the removal of calculus from the root surface: An in vitro study
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Domenico Marcattili, Leonardo Mancini, Francesco Tarallo, Fabio Casalena, Carla Pietropaoli, and Enrico Marchetti
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debridement ,dental calculus ,diode laser ,root planing ,scaling ,Dentistry ,RK1-715 - Abstract
Abstract Introduction Scaling and root planning (SRP) is still the gold standard of nonsurgical periodontal therapy, and it has been accompanied by several supportive therapies in recent years. One of the most studied methods is the diode laser, thanks to its thermal and bactericidal properties. Our trial intended to verify whether it could influence the chemical bond between calculus and the root surface. Objectives The aim of the study was to assess the efficacy of the diode laser prior the mechanical removal of calculus in an in vitro application. The reduction in time and the number of strokes required to clean the untreated root surfaces were evaluated as primary outcomes. The pressure was considered as a secondary outcome. Methods A total of 75 extracted human teeth with subgingival calculus were assigned equally among three treatment groups (n = 25) according to the size of the occupied areas, which were classified by evaluating the pixel numbers. The groups were assigned to either no pretreatment application (A), Laser Diode Fox III (Sweden & Martina) (B) or Wiser Laser Evolution (Doctor Smile) (C). The weight for instrumentation was calibrated for an After Five curette (Hu‐Friedy, Chicago). A new set of tools was used for each group, and the curettes were sharpened after each use with the Sidekick sharpener (Hu‐Friedy, Chicago). Results A Kruskal–Wallis test was used to assess the significance for each considered parameter. The results were statistically significant for each parameter for the two groups where the laser was used compared to the control group. Conclusions Despite the limitations of an in vitro study, data showed that the diode laser had an overall positive effect on root debridement, facilitating SRP in terms of stroke count, time, and pressure. more...
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- 2023
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43. Profiling small RNAs in fecal immunochemical tests: is it possible?
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Einar Birkeland, Giulio Ferrero, Barbara Pardini, Sinan U. Umu, Sonia Tarallo, Sara Bulfamante, Geir Hoff, Carlo Senore, Trine B Rounge, and Alessio Naccarati
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Small RNA sequencing ,Fecal immunochemical test (FIT) ,Colorectal cancer screening ,Stool biomarkers ,Microbiome ,microRNAs ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Fecal microRNAs represent promising molecules with potential clinical interest as non-invasive diagnostic and prognostic biomarkers. Colorectal cancer (CRC) screening based on the fecal immunochemical test (FIT) is an effective tool for prevention of cancer development. However, due to the poor sensitivity of FIT especially for premalignant lesions, there is a need for implementation of complementary tests. Improving the identification of individuals who would benefit from further investigation with colonoscopy using molecular analysis, such as miRNA profiling of FIT samples, would be ideal due to their widespread use. In the present study, we assessed the feasibility of applying small RNA sequencing to measure human miRNAs in FIT leftover buffer in samples from two European screening populations. We showed robust detection of miRNAs with profiles similar to those obtained from specimens sampled using the established protocol of RNA stabilizing buffers, or in long-term archived samples. Detected miRNAs exhibited differential abundances for CRC, advanced adenoma, and control samples that were consistent for FIT and RNA-stabilizing buffers. Interestingly, the sequencing data also allowed for concomitant evaluation of small RNA-based microbial profiles. We demonstrated that it is possible to explore the human miRNome in FIT leftover samples across populations and envision that the analysis of small RNA biomarkers can complement the FIT in large scale screening settings. more...
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- 2023
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44. Navigation in reverse shoulder arthroplasty: how the lateralization of glenosphere can affect the clinical outcome
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Tarallo, Luigi, Giorgini, Andrea, Micheloni, Gianmario, Montanari, Marta, Porcellini, Giuseppe, and Catani, Fabio
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- 2023
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45. Facial Nerve Injury after Extracapsular Dissection for Benign Parotid Tumors with and without Intraoperative Monitoring: A Retrospective Study of a Single Center
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Maria Giulia Cristofaro, Walter Colangeli, Francesco Ferragina, Giuseppe Tarallo, Angelo Ruggero Sottile, Maria Grazia Ioppolo, Antonella Arrotta, and Ida Barca
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benign parotid tumor ,extracapsular dissection ,postoperative facial nerve paralysis ,intraoperative facial nerve monitoring ,Medicine (General) ,R5-920 - Abstract
Background: Facial nerve injury (FNI) is the most common complication of parotid surgery and manifests as FN paralysis. The use of intraoperative facial nerve monitoring (IFNM) is becoming an established intraoperative aid for surgeons, assisting in the identification of the location and dissection of the facial nerve trunk or branches. The postoperative outcomes of parotid surgery with and without monitoring have been addressed in only a limited number of studies. Objective: The objective of this study is to evaluate the incidence of postoperative paralysis in patients undergoing extracapsular dissection (ED) for benign parotid tumors concerning the use or non-use of IFNM. Materials and Methods: The retrospective study was conducted at the Maxillo-Facial Department of the Magna Graecia University of Catanzaro. The patients were divided into two groups: Group 1 consisted of patients who underwent surgery without IFNM (1 January 2015 to 31 December 2018); Group 2, on the other hand, consisted of patients who underwent surgery with IFNM (1 January 2019 to 31 December 2022). Group 2 employed the Nerve Integrity Monitor (Medtronic’s NIM®). To classify the FN function, we employed the modified House–Brackmann classification system. To evaluate the dependence between the “use of IFNM” and “postoperative paralysis”, a descriptive analysis was conducted, including applying the Chi-squared test and calculating the Pearson correlation. Subsequently, a binary logistic regression model was applied to further evaluate the correlation between the latter. The level of statistical significance was set at p < 0.05. Results: A total of 276 patients were included in the study: 120 subjects were assigned to Group 1 (43.5%, comprising 60 men and 60 women) and 156 subjects were assigned to Group 2 (56.5%, comprising 93 men and 63 women). In 91.7% of the cases (n. 253, precisely 105 in Group 1 and 148 in Group 2), no FNI occurred. In 8.33% of the cases (n. 23, specifically 15 in Group 1 and 8 in Group 2), postoperative paralysis was observed. Of these subjects, only two in Group 1 had permanent paralysis (8.69%); therefore, 91.31% had transient paralysis. As a result, 91.31% of the subjects exhibited transient paralysis. In the case of FNI, 78% of the cases involved the marginal mandibular branch (n. 18), 13% involved the temporo-zygomatic branch (n. 3), and 7% involved more than one branch (n = 2). The results of the multivariable binary logistic regression analysis demonstrated that the use of IFNM was a statistically significant influencing factor, with an estimated reduction in postoperative paralysis of approximately 62% (OR 0.378; 95% CI: 0.155–0.92). In Group 2, the occurrence of transient complications was significantly reduced (OR 0.387; 95% CI: 0.149–1.002 with p < 0.05). Discussion and Conclusions: The use of IFNM in the ED for benign parotid tumors significantly reduces the rate of FNI and, consequently, postoperative FN paralysis. On the other hand, the use of monitoring systems must not replace the experience and anatomical knowledge of the surgeon. more...
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- 2024
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46. A Review of the Literature on Episodes of Acute Fentanyl Intoxication in Pediatric Age and Toxicological Applications
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Matteo Antonio Sacco, Saverio Gualtieri, Alessandro Pasquale Tarallo, Lucia Tarda, Maria Cristina Verrina, Andrea Costa, and Isabella Aquila
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fentanyl ,opioids ,children ,intoxication ,Chemical technology ,TP1-1185 - Abstract
Fentanyl is an opioid with powerful analgesic effects and a high speed of action. Due to its pharmacological properties, this molecule has therapeutic application as an anesthetic in surgery or as palliative therapy for cancer patients. Unfortunately, in recent years, the easy availability of this substance, the low cost and the illegal online market have favored the large-scale diffusion of fentanyl. Fentanyl is available in different forms, including nasal spray, oral patches, soluble capsules, aerosol or the new version of fentanyl mixed with other drugs, making its use very widespread. Subjects of various ages are involved in fentanyl consumption, including minors that have not yet reached adolescence. In this work, we performed a literature review using the search engines PubMed NCBI and SCOPUS regarding episodes of acute fentanyl intoxication occurring in those of a pediatric age using the Mesh Terms “fentanyl” AND “overdose” AND “children”. The inclusion criteria were English papers published in the last 10 years regarding the cases of children under the age of 10. We evaluated the most frequent methods of intake and the circumstances of such episodes. In cases of death, we analyzed the autopsy, the toxicological findings and the investigations carried out. The review results show that in this age group (under < 10 y.o. s), it is possible to identify the risk factors for fentanyl intake, such as the presence of this molecule within the family unit due to drug addiction or medical therapy. The results also demonstrate a significant risk of underestimation of this phenomenon, since the molecule is often not investigated through adequate toxicological analysis. These results, therefore, suggest always carrying out toxicological investigations in the case of suspected fentanyl intoxication, both on patients or cadavers. The investigations must always include a urinary screening for opiates, and the request for a second level analysis with molecule dosage in cases of positivity or in cases of strong suspicion for assumption. In cases of intoxication in a family context of drug addiction, it is necessary to investigate the chronicity of the intake through hair analysis and evaluate the possible co-administration of other drugs. In conclusion, we suggest a protocol, applicable both on patients or cadavers, which can be useful for physicians and forensic pathologists in order to promptly identify these cases and allow for the reporting of them to the judicial authorities with the adoption of strict prevention and control measures. more...
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- 2024
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47. Extracranial Nasosinusal Meningioma: A Case Report of a Rare Entity
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Romano, Antonio, Maffia, Francesco, Iaquino, Vincenzo, Tarallo, Giuseppe, Abbate, Vincenzo, De Fazio, Gianluca Renato, Committeri, Umberto, Bonavolontà, Paola, Califano, Luigi, and Dell’Aversana Orabona, Giovanni more...
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- 2023
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48. Erythrocyte sedimentation rate in heartworm naturally infected dogs 'with or without' Leishmania infantum seropositivity: an observational prospective study
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Maria Alfonsa Cavalera, Oana Gusatoaia, Annamaria Uva, Floriana Gernone, Viviana Domenica Tarallo, Rossella Donghia, Marco Silvestrino, and Andrea Zatelli
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ESR ,APP ,inflammatory markers ,Dirofilaria immitis ,canine leishmaniosis ,coinfections ,Veterinary medicine ,SF600-1100 - Abstract
Canine heartworm disease by Dirofilaria immitis and canine leishmaniosis by Leishmania infantum (CanL) are both vector-borne diseases with frequently overlapping endemicity and able to trigger the acute phase response, being characterized by variations in acute phase proteins (APP). Recently, erythrocyte sedimentation rate (ESR), an indicator of inflammation, has gained attention in veterinary medicine, proving useful in several conditions that include CanL active forms in dogs. This study aims to evaluate ESR in heartworm-infected dogs, compare levels with heartworm-infected and L. infantum seropositive dogs as well as clinically healthy dogs, and assess correlations with other laboratory parameters. From October 2022 to January 2023, a prospective observational study was conducted enrolling heartworm-infected (Dirofilaria group) and heartworm-infected L. infantum seropositive (Dirofilaria/Leishmania group) animals subgrouped according to the CanL clinical form (Dirofilaria/Leishmania active and non-active groups). A group of clinically healthy dogs (control group) was also included. For each dog enrolled physical examination and laboratory tests (complete blood count, biochemical panel including APP, serum protein electrophoresis) were performed. Dirofilaria and Dirofilaria/Leishmania groups presented a significantly higher ESR level compared to healthy dogs. Dirofilaria/Leishmania active group had the highest ESR level among the groups considered. Dirofilaria/Leishmania non-active group had an ESR similar to the Dirofilaria group, but significantly higher and lower compared to the control and the Dirofilaria/Leishmania active group, respectively. A significant positive correlation between ESR and C-Reactive Protein has been found in all groups except for the Dirofilaria/Leishmania non-active group. In Dirofilaria/Leishmania active group a strong positive correlation between ESR and gamma globulins percentage as well as a strong negative correlation between ESR and albumin, albumin/globulins ratio were found. Overall, the ESR was confirmed to be an inflammation marker as well as a helpful disease index, being notably increased in heartworm-infected dogs affected by an active form of CanL. more...
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- 2024
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49. SnoRNA profiling in colorectal cancer and assessment of non-invasive biomarker capacity by ddPCR in fecal samples
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Javier Gómez-Matas, Saray Duran-Sanchon, Juan-José Lozano, Giulio Ferrero, Sonia Tarallo, Barbara Pardini, Alessio Naccarati, Antoni Castells, and Meritxell Gironella
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Health sciences ,Internal medicine ,Medical specialty ,Medicine ,Oncology ,Science - Abstract
Summary: Small nucleolar RNAs (snoRNAs) have been identified dysregulated in several pathologies, and these alterations can be detected in tissues and in circulation. The main aim of this study was to analyze the whole snoRNome in advanced colorectal neoplasms and to identify new potential non-invasive snoRNA-based biomarkers in fecal samples by different analytical approaches. SNORA51, SNORD15B, SNORA54, SNORD12B, SNORD12C, SNORD72, SNORD89, and several members of SNORD115 and SNORD116 clusters were consistently deregulated in both tissue sets. After technical validation, SNORA51 and SNORD15B were detected in FIT+ samples. SNORA51 was significantly upregulated in FIT+ samples from CRC patients compared to healthy controls. This upregulation, together with the fecal hemoglobin concentration, was sufficient to identify, among FIT+ individuals, patients with CRC (AUC = 0.86) and individuals with advanced adenomas (AUC = 0.68). These findings portray snoRNAs as an alternative source of candidates for further studies and SNORA51 appears as a potential non-invasive biomarker for CRC detection. more...
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- 2024
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50. Toward a quantum-enhanced strontium optical lattice clock at INRIM
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Tarallo, Marco G.
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Physics - Atomic Physics - Abstract
The new strontium atomic clock at INRIM seeks to establish a new frontier in quantum measurement by joining state-of-the-art optical lattice clocks and the quantized electromagnetic field provided by a cavity QED setup. The goal of our experiment is to apply advanced quantum techniques to state-of-the-art optical lattice clocks, demonstrating enhanced sensitivity while preserving long coherence times and the highest accuracy. In this paper we describe the current status of the experiment and the prospected sensitivity gain for the designed cavity QED setup., Comment: Proceedings of the Italian National Conference on the Physics of Matter (FisMat 2019), held in Catania, Italy, September 30-October 4, 2019, E. Puppin (Ed.). Journal version is open access more...
- Published
- 2020
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