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394 results on '"Tarín, Juan J."'

28. Variants translating reduced expression of the beta estrogen receptor gene were associated with increased carotid intima media thickness

Author

Cano-Marquina, Antonio-Jorge, García-Pérez, Miguel-Ángel, Tarín, Juan J., Maceira, Alicia M., Cosín-Sales, Juan, and Cano, Antonio

Subjects
Observational Study, postmenopausal women, Middle Aged, Carotid Intima-Media Thickness, Polymorphism, Single Nucleotide, Hospitals, University, Postmenopause, Cross-Sectional Studies, Heart Disease Risk Factors, Risk Factors, cardiovascular system, Linear Models, Estrogen Receptor beta, Humans, Female, cardiovascular diseases, atherosclerosis, carotid IMT, Biomarkers, Research Article, estrogens, Aged, Ultrasonography
Abstract

There is debate on the role of estrogens in modulating the risk for atherosclerosis in women. Our purpose was to investigate whether the size of the estrogenic impact was independently associated with variation of carotid intima-media thickness (IMT) in healthy late postmenopausal women. The levels of circulating estrogens have been used in previous studies but the influence of SNPs of the estrogen receptors (ER) α and β have not been investigated. We performed a crossed-sectional study of 91 women in a university hospital. We used a double approach in which, in addition to the measurement of estradiol levels by ultrasensitive methods, genetic variants (SNPs) associated with differing expression of the ER α and β genes were assessed. Multivariable analysis was used to examine the association of candidate factors with the value of IMT and plaque detection at both the carotid wall and the sinus. A genotype combination translating reduced gene expression of the ERβ was directly associated with IMT at both the carotid wall (P = .001) and the sinus (P = .002). Other predictors of IMT were the levels of glucose, positively associated with IMT at both the carotid wall (P

Published
2021

47. Acute stress may induce ovulation in women

Author

Cano Antonio, Hamatani Toshio, and Tarín Juan J

Subjects
Gynecology and obstetrics, RG1-991, Reproduction, QH471-489
Abstract

Abstract Background This study aims to gather information either supporting or rejecting the hypothesis that acute stress may induce ovulation in women. The formulation of this hypothesis is based on 2 facts: 1) estrogen-primed postmenopausal or ovariectomized women display an adrenal-progesterone-induced ovulatory-like luteinizing hormone (LH) surge in response to exogenous adrenocorticotropic hormone (ACTH) administration; and 2) women display multiple follicular waves during an interovulatory interval, and likely during pregnancy and lactation. Thus, acute stress may induce ovulation in women displaying appropriate serum levels of estradiol and one or more follicles large enough to respond to a non-midcycle LH surge. Methods A literature search using the PubMed database was performed to identify articles up to January 2010 focusing mainly on women as well as on rats and rhesus monkeys as animal models of interaction between the hypothalamic-pituitary-adrenal (HPA) and hypothalamic-pituitary-gonadal (HPG) axes. Results Whereas the HPA axis exhibits positive responses in practically all phases of the ovarian cycle, acute-stress-induced release of LH is found under relatively high plasma levels of estradiol. However, there are studies suggesting that several types of acute stress may exert different effects on pituitary LH release and the steroid environment may modulate in a different way (inhibiting or stimulating) the pattern of response of the HPG axis elicited by acute stressors. Conclusion Women may be induced to ovulate at any point of the menstrual cycle or even during periods of amenorrhea associated with pregnancy and lactation if exposed to an appropriate acute stressor under a right estradiol environment.

Published
2010
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48. Bazedoxifene increases the proliferation of human arterial endothelial cells but does not affect the expression of cyclins A, B, and D1 and of p27Kip1.

Author

Dudenko, Darya, Gómez, Raúl, García-Pérez, Miguel-Ángel, Tarín, Juan J., and Cano, Antonio

Subjects
ENDOTHELIAL cells, RALOXIFENE, CYCLINS, UMBILICAL arteries, VASCULAR endothelium, CELL size
Abstract

Copyright of Gynecological Endocrinology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2021
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