1. Cytotoxic Activity of Zinc Oxide Nanoparticles Using Zingiber officinale Rhizome Extracts against Human Ovarian Cancer (SKOV-3) Cell Line
- Author
-
Sayantani Pal, Tapas Kumar Pal, and Shila Elizabeth Besra
- Subjects
Pharmaceutical Science - Abstract
Zinc Oxide (ZnO) nanoparticle was synthesized using rhizome extracts of Zingiber officinale for in-vitro anti-cancer study in our previous paper. Treated with ZnO nanoparticle with Zingiber officinale extracts (ZGNPE) showed significant inhibition on the human chronic myeloid leukemia cells whereas in normal human embryonic kidney cells showed insignificant toxicity. Therefore, further more we evaluate the cytotoxic activity of ZnO nanoparticle with Zingiber officinale extracts on human ovarian cancer cells (SKOV-3). Cytotoxic activity was performed by MTT assay. Treated with ZGNPE sample 4,5 and 6 showed significant inhibition on the SKOV-3 cancer cells. The IC50 values were 48.49 µg for ZGNP-4, 39.83µg for ZGNP-5 and 45.36 µg for ZGNP-6 respectively. Thus, ZGNPE may be used as chemotherapy drug and an enormous medical application with less toxicity in future. The characterization of nanoparticle was confirmed using ultraviolet spectroscopy and Fourier Transfer Infrared Spectroscopy (FTIR). The ZGNPE characterization also used the UV-Vis Spectrophotometer spectrum technique to measure the structural characterization of nanoparticles by determine the absorbance measurement.
- Published
- 2022
- Full Text
- View/download PDF