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Your search keyword '"Tapanadechopone, Pairath"' showing total 14 results
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14 results on '"Tapanadechopone, Pairath"'

3. Associations of CB1 cannabinoid receptor (CNR1) gene polymorphisms with risk for alcohol dependence

Author

Pabalan, Noel, Chaweeborisuit, Phanthip, Tharabenjasin, Phuntila, Tasanarong, Adis, Jarjanazi, Hamdi, Eiamsitrakoon, Thanee, and Tapanadechopone, Pairath

Subjects
Genotype, alcohol dependence, Polymorphism, Single Nucleotide, White People, meta-analysis, Black or African American, Alcoholism, Meta-Analysis as Topic, Receptor, Cannabinoid, CB1, Humans, Genetic Predisposition to Disease, Systematic Review and Meta-Analysis, cannabinoid receptor 1 polymorphisms, Research Article, Genome-Wide Association Study
Abstract

Objectives: Reported associations of the cannabinoid receptor 1 (CNR1) single nucleotide polymorphisms (SNPs) with alcohol dependence (AD) have been inconsistent, prompting a meta-analysis to obtain more precise estimates. Methods: A Boolean search of 4 databases (PubMed, Scopus, Google Scholar, and Mednar) sought articles that evaluated the association between CNR1 polymorphisms and risk of AD. We selected the articles with sufficient genotype frequency data to enable calculation of odds ratios (ORs) and 95% confidence intervals (CIs). Using the Population Intervention Comparators Outcome elements, AD patients (P) were compared by genotype data between AD-participants (I) and non-AD-participants (C) in order to determine the risk of AD (O) attributed to the CNR1 SNPs. Analyzing 4 SNPs (rs1049353, rs1535255, rs2023239, and rs806379) using standard genetic models, we examined associations where multiple comparisons were Holm–Bonferroni corrected. The pooled ORs were assessed for aggregate statistical power and robustness (sensitivity analysis). Subgroups were Caucasians and African-Americans. Results: From 32 comparisons, 14 were significant indicating increased risk, from which 5 outcomes (P-value for association [Pa] = .003 to

Published
2021

9. The Effects of High Glucose on Adipogenic and Osteogenic Differentiation of Gestational Tissue-Derived MSCs.

Author

Hankamolsiri, Weerawan, Manochantr, Sirikul, Tantrawatpan, Chairat, Tantikanlayaporn, Duangrat, Tapanadechopone, Pairath, and Kheolamai, Pakpoom

Subjects
BONE marrow cells, MESENCHYMAL stem cells, TYPE 2 diabetes treatment, FAT cells, PHYSIOLOGICAL effects of glucose
Abstract

Most type 2 diabetic patients are obese who have increased number of visceral adipocytes. Those visceral adipocytes release several factors that enhance insulin resistance making diabetic treatment ineffective. It is known that significant percentages of visceral adipocytes are derived from mesenchymal stem cells and high glucose enhances adipogenic differentiation of mouse bone marrow-derived MSCs (BM-MSCs). However, the effect of high glucose on adipogenic differentiation of human bone marrow and gestational tissue-derived MSCs is still poorly characterized. This study aims to investigate the effects of high glucose on proliferation as well as adipogenic and osteogenic differentiation of human MSCs derived from bone marrow and several gestational tissues including chorion, placenta, and umbilical cord. We found that high glucose reduced proliferation but enhanced adipogenic differentiation of all MSCs examined. The expression levels of some adipogenic genes were also upregulated when MSCs were cultured in high glucose. Although high glucose transiently downregulated the expression levels of some osteogenic genes examined, its effect on the osteogenic differentiation levels of the MSCs is not clearly demonstrated. The knowledge gained from this study will increase our understanding about the effect of high glucose on adipogenic differentiation of MSCs and might lead to an improvement in the diabetic treatment in the future. [ABSTRACT FROM AUTHOR]

Published
2015
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11. Detection of Proteoglycan Core Proteins with Glycosaminoglycan Lyases and Antibodies.

Author

Walker, John M., Iozzo, Renato V., Couchman, John R., and Tapanadechopone, Pairath

Abstract

Proteoglycans are quite abundant components of many extracellular matrices, while most cell surfaces also bear these macromolecules. Frequently the profiles are complex. For example, several members of the syndecan and glypican families of cell surface heparan sulfate proteoglycans may be present on a single cell type (1,2). Some extracellular matrices, e.g., from brain, may also contain a variety of proteoglycans including several members of the hyalectans or aggregating proteoglycans such as neurocan, brevican, and versican (3). Frequently it is useful to monitor the nature and variety of proteoglycans in a pool from tissues or cell cultures in a simple manner, before moving on to further purification steps, use of core protein-specific antibodies, or pursuit of a potentially novel core protein. [ABSTRACT FROM AUTHOR]

Published
2001
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14. Childhood disintegrative disorder: a case report.

Author

Tapanadechopone P

Subjects
Child, Child Development Disorders, Pervasive physiopathology, Child Development Disorders, Pervasive psychology, Humans, Male, Thailand, Child Development Disorders, Pervasive diagnosis, Regression, Psychology
Abstract

Childhood Disintegrative Disorder (CDD), a clinical syndrome distinctfrom childhood autism, is a rare unremittingly pervasive developmental disorder resultingfrom disintegration ofmentalfunctions and progressive neurological abnormality. This rare condition is characterized by regression or loss ofpreviously acquired language and social skills after a period of at least 2 years of normal development. This report presenting a case of a 10-year-old boy who presented with normal development until 3-4 years of age followed by gradually developmental deterioration in previously acquired social skills, language and intellectual functions with aberrant behaviors suggestive of childhood disintegrative disorder This case is reported as a very rare case and there is no previous official report in Thailand.

Published
2015

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