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12. Fat mass and obesity-associated protein (FTO) affects midpalatal suture bone remodeling during rapid maxillary expansion.

Author

Zhao, Tingting, Tao, Zhendong, Zhang, Gengming, Zhu, Jiaqi, Du, Mingyuan, Hua, Fang, and He, Hong

Subjects
MAXILLARY expansion, BONE remodeling, ADIPOSE tissues, SMALL interfering RNA, DIMETHYL sulfoxide, SUTURES
Abstract

Background The fat mass and obesity-associated protein (FTO) is an RNA demethylase that contributes to several physiological processes. Nonetheless, the impact of FTO on bone remodeling in the midpalatal suture while undergoing rapid maxillary expansion (RME) remains unclear. Methods First, to explore the expression of FTO in the midpalatal suture during RME, six rats were randomly divided into two groups: Expansion group and Sham group (springs without being activated). Then, suture mesenchymal stem cells (SuSCs) were isolated as in vitro model. The expression of FTO was knocked down by small interfering RNA to study the effect of FTO on the osteogenic differentiation of SuSCs. Finally, to evaluate the function of FTO in the process of bone remodeling in the midpalatal suture, ten rats were randomly divided into two groups: FB23-2 group (10 μM, a small molecule inhibitor of FTO) and DMSO group (control). Results Increased arch width and higher expression of OCN and FTO in the midpalatal area were observed in expansion group (P  < .05). In the in vitro model, the mRNA expression levels of Runx2, Bmp2, Col1a1, Spp1, and Tnfrsf11b were decreased (P  < .05) upon knocking down FTO. Additionally, the protein levels of RUNX2 and OPN were also decreased (P  < 0.05). Adding FB23-2, a small-molecule inhibitor targeting FTO, to the medium of SuSCs caused a decrease in the mRNA expression levels of Runx2, Bmp2, Col1a1, Spp1, and Tnfrsf11b (P  < 0.05). There was a statistically significant difference in evaluating the expression of OCN and OPN on the palatal suture between the FB23-2 and DMSO groups (P  < .05). Limitation The molecular mechanisms by which FTO regulates SuSCs osteogenesis remain to be elucidated. The FTO conditional knock out mouse model can be established to further elucidate the role of FTO during RME. Conclusion FTO contributes to the osteogenic differentiation of SuSCs and plays a promoting role in midpalatal suture bone remodeling during the RME. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Dietary Restriction Attenuates Inflammation and Protects Mouse Skin from High-Dose Ultraviolet B Irradiation

Author

Tang, Duozhuang, Wu, Jianying, Wang, Yiting, Cui, Hui, Tao, Zhendong, Lei, Lang, Zhou, Zhuangfa, and Tao, Si

Subjects
Inflammation, Mice, Aging, Ultraviolet Rays, Animals, Original Articles, Geriatrics and Gerontology, Diet, Skin
Abstract

Ultraviolet B (UVB) radiation may influence the occurrence or even worsen cutaneous disorders from inflammatory to neoplastic disorders. Dietary restriction (DR) is a well-known regimen that can retard aging-associated pathologies, and is shown by us and others that it can significantly inhibit inflammation under various conditions, including in both undisturbed and stressed settings. It is unknown whether DR could act as a nonpharmacological factor to protect skin against UVB-induced damage. In this study, we performed 30% DR to mice 1 week before UVB irradiation (798.6 mJ/cm(2)). Remarkably, continuous DR significantly ameliorated UVB-induced skin damage and histological changes, associated with a great reduction in the inflammatory responses in the skin. Intriguingly, refed DR mice with ad libitum diet even 24 hours postirradiation reinflamed the inflammatory responses and induced significantly strong damage to the skin. Together, this study provides the first experimental evidence that DR greatly protects mouse skin from high dose of UVB irradiation, which if translatable could have great implications in human beings.

Published
2022

22. The Use of Functionalized Silk Fibroin Films as a Platform for Optical Diffraction‐Based Sensing Applications

Author

Zhou, Zhitao, primary, Shi, Zhifeng, additional, Cai, Xiaoqing, additional, Zhang, Shaoqing, additional, Corder, Stephanie G., additional, Li, Xinxin, additional, Zhang, Yeshun, additional, Zhang, Guozheng, additional, Chen, Liang, additional, Liu, Mengkun, additional, Kaplan, David L., additional, Omenetto, Fiorenzo G., additional, Mao, Ying, additional, Tao, Zhendong, additional, and Tao, Tiger H., additional

Published
2017
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23. Preparation of MgTiO3 ceramics by high energy ball milling

Author

Meng Shanshan, Tao Zhendong, Teng Tie-li, Yang Zhong-xi, Wang Yingzi, and Zhang Ying

Subjects
Diffraction, High energy, Materials science, Metallurgy, Sintering, Crystal structure, visual_art, visual_art.visual_art_medium, General Materials Science, Ceramic, Composite material, High-resolution transmission electron microscopy, Porosity, Ball mill
Abstract

MgTiO3 precursor was mechanochemically synthesized by high-energy ball milling of MgO and TiO2. The sintering characteristic of the resulted MgTiO3 precursor was investigated. The experimental results indicate that particles of both MgO and TiO2 powders become smaller rapidly, and then the crystalline structures of MgO and TiO2 change significantly. MgTiO3 was observed by XRD after 30 hours of ball milling. Strong diffraction peaks of MgTiO3 were observed after 50 hours of ball milling. HRTEM observation proves that dense MgTiO3 ceramics with a compact crystalline structure can be sintered from mechanochemically activated MgTiO3 precursor, the volume density of the resulting ceramic is as high as 95% of the theoretical density, the porosity and average pore diameter of the ceramic are measured as 4.95% and 50 nm respectively, and the transverse strength exceeded 500 MPa.

Published
2006

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