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13. Recurrence of new-onset post-operative AF after cardiac surgery: detected by implantable loop recorders: A systematic review and Meta-analysis

Author

Kaur, Hargun, primary, Tao, Brendan, additional, Silverman, Max, additional, Healey, Jeffrey S., additional, Belley-Cote, Emilie P., additional, Islam, Shofiqul, additional, Whitlock, Richard P., additional, Devereaux, Philip J., additional, Conen, David, additional, Bidar, Elham, additional, Kawczynski, Michal, additional, Ayala-Paredes, Félix, additional, Ayala-Valani, Luciano M, additional, Sandgren, Emma, additional, El-Chami, Mikhael F, additional, Jørgensen, Troels Højsgaard, additional, Thyregod, Hans Gustav Hørsted, additional, Sabbag, Avi, additional, and McIntyre, William F., additional

Published
2024
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24. Diversity in enrollment to clinical trials for cataract medicine and surgery: meta-analysis.

Author

Ka-Lok Tao, Brendan, Jim Shenchu Xie, Xia, Manvis, Marzban, Sahand, Vosoughi, Amir R., Ahuja, Nina, and Rocha, Guillermo

Subjects
*CATARACT surgery, *CLINICAL trials, *RACE, *GLOBAL burden of disease, *CATARACT, *PHACOEMULSIFICATION
Abstract

Purpose: To investigate sex, racial, and ethnic disparities in patient enrollment across cataract trials registered in the United States. Setting: Participants enrolled in high-quality (reduced risk of bias), U.S.-registered (on ClinicalTrials.gov), cataract-related randomized controlled trials (RCTs). RCTs must be completed, have used double or greater masking, and have published results through the registry or a scholarly journal. Design: Cross-sectional database study. Methods: Trial (study sponsor country, study site location, trial initiation year, study phase, and study masking) and demographic data (sex, race, and ethnicity according to U.S. reporting guidelines) were collected. The Global Burden of Disease database provided sex-based cataract disease burdens. Pooled participation-to- prevalence ratios (PPRs) with 95% CIs were calculated for female sex, with values between 0.8 and 1.2 constituting sufficient study enrollment. Kruskal-Wallis tests (α = 0.05) with subsequent post hoc comparisons were used to evaluate demographic rep-resentations stratified by trial characteristics. Results: From 864 records, 100 clinical trials (N = 67 874) were identified, of which 97 (N = 67 697) reported sex demographics with a pooled female PPR of 0.89 (95% CI, 0.85-0.94). Of the 67 697 total participants, the absolute female enrollment was 19 062 (28.16%). Ethnicity and race were reported in 9 (N = 1792) and 26 trials (N = 23181), respectively. Among trials that reported race, most were White (N = 19574; 84.44%). Conclusions: High-quality, U.S.-registered, cataract trials enrolled acceptable proportions of women. However, the absolute number of female and racialized participants was low. Race and ethnicity were underreported. Disparity trends predominately held across secondary variables. To promote generalizability, future trials should pursue equitable demographic enrollment. [ABSTRACT FROM AUTHOR]

Published
2024
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26. Probiotics, Prebiotics, Lactoferrin, and Combination Products for Prevention of Mortality and Morbidity in Preterm Infants

Author

Wang, Yuting, primary, Florez, Ivan D., additional, Morgan, Rebecca L., additional, Foroutan, Farid, additional, Chang, Yaping, additional, Crandon, Holly N., additional, Zeraatkar, Dena, additional, Bala, Malgorzata M., additional, Mao, Randi Q., additional, Tao, Brendan, additional, Shahid, Shaneela, additional, Wang, Xiaoqin, additional, Beyene, Joseph, additional, Offringa, Martin, additional, Sherman, Philip M., additional, El Gouhary, Enas, additional, Guyatt, Gordon H., additional, and Sadeghirad, Behnam, additional

Published
2023
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33. Rhythm vs. Rate Control in Patients with Postoperative Atrial Fibrillation after Cardiac Surgery: A Systematic Review and Meta-Analysis

Author

Ahmed, Muneeb, primary, Belley-Coté, Emilie P., additional, Qiu, Yuan, additional, Belesiotis, Peter, additional, Tao, Brendan, additional, Wolf, Alex, additional, Kaur, Hargun, additional, Ibrahim, Alex, additional, Wong, Jorge A., additional, Wang, Michael K., additional, Healey, Jeff S., additional, Conen, David, additional, Devereaux, Philip James, additional, Whitlock, Richard P., additional, and Mcintyre, William F., additional

Published
2023
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36. Assessment of Neurology Residency Program Websites across North America during COVID-19

Author

Tsai, Chia-Chen, Wen, William, Tao, Brendan, Chen, Tychicus, Marzoughi, Sina, Khan, Muhammad T., and Khosa, Faisal

Abstract

ABSTRACTWith virtual interviews for residency applications, residency program websites have become increasingly important resources for applicants. We evaluated the comprehensiveness of US and Canadian neurology residency program website, comparing this to published rankings of the best neurology and neurosurgery hospitals (for US programs) and number of residency positions (for US and Canadian programs). US program websites were found to be largely more comprehensive than Canadian websites, more extensive websites were associated with better program rankings and fewer residency seats in the US, and US regional differences in comprehensiveness were present. We recommend standardized guidelines to increase website comprehensiveness across programs.

Published
2024
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38. Inappropriate Indexing of Case Reports to the "Papilledema" Subject Heading: A Systematic Review.

Author

Tao, Brendan K., Vosoughi, Amir R., Pandya, Bhadra U., Ishaq, Junaid, Margolin, Edward A., and Micieli, Jonathan A.

Abstract

Background: Papilledema must be managed distinctly from other causes of optic disc edema (ODE) due to its basis in raised intracranial pressure (ICP). However, evidence indicates that the term "papilledema" is widely misused across specialties to describe ODE without raised ICP. Sources of this misconception remain undiscerned. Because all physicians consult medical databases, our objective was to evaluate whether nonspecific "papilledema" subject heading definitions misleadingly associate articles on other conditions with papilledema proper. Methods: Systematic review of case reports, prospectively registered on PROSPERO (CRD42022363651). MEDLINE and Embase were searched to July 2022 for any full-length case report indexed to the "papilledema" subject heading. Studies were graded for incorrect indexing, defined as cases lacking evidence for raised ICP. Nonpapilledema diagnoses were assigned to a predefined set of diseases and pathophysiological mechanisms for subsequent comparison. Results: Incorrect indexing occurred in 40.67% of 949 included reports. Embase-derived studies were misindexed significantly less than MEDLINE-derived studies (P, 0.01). There was also significant heterogeneity in incorrect indexing among specific diseases (P = 0.0015) and mechanisms (P = 0.0003). The most commonly misindexed diseases were uveitis (21.24% of errors), optic neuritis (13.47%), and instances with no mention of ODE (13.99%). The most commonly misindexed mechanisms were inflammation (34.97%), other mechanism (e.g., genetic; 25.91%), and ischemia (20.47%). Conclusions: Database subject headings, especially from MEDLINE, do not adequately distinguish between true papilledema and other causes of ODE. Inflammatory diseases were most often incorrectly indexed among other diseases and mechanisms. Current "papilledema" subject headings should be revised to reduce the probability of misinformation. [ABSTRACT FROM AUTHOR]

Published
2023
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41. A Cross-Sectional Study of Sex, Race, and Ethnic Representation in Burn Registered Clinical Trials

Author

Sheikh-Oleslami, Sara, Tao, Brendan, Papp, Bettina, Luthra, Shreya, and Papp, Anthony

Abstract

Purpose: The demographic proportions of plastic surgery trials approximating real-world disease have not well been studied. Judicious trial representation is essential in evaluation of treatments across diverse patient populations. Herein, we investigate sex, racial, and ethnic disparities in patient enrollment across burn trials. Methods: Cross-sectional analysis of participants enrolled in high-quality, with reduced risk of bias, randomized controlled trials (RCT) on burns registered on clinicaltrials.gov under the query “burn.” Completed RCTs reporting at least two demographic groups, employing double masking or greater, and with results accessible through the registry or publications were included. Trial characteristics (sponsor country, site location, initiation year, study phase, masking) and demographic data (sex, race, ethnicity per US reporting guidelines) were collected. The Global Burden of Disease database provided sex-based burn disease burdens. The primary outcome was the population-to-prevalence ratio of enrolled female participants. Secondary outcomes included representation of racial and ethnic populations as related to study blinding, phase, and study/sponsor locations. Results: Of 546 records, 39 trials met the inclusion criteria (2919 participants). All trials reported sex demographics, with females comprising 37.02% of all participants (PPR = 0.71, 95% CI [0.59, 0.82], likely indicating underrepresentation against their empiric disease burden). Only 7 and 9 trials reported ethnicity and race, respectively, although not comprehensively. Among trials reporting race or ethnicity, Caucasians and Black persons comprised 57.52% and 21.80% of participants, respectively, while only 9.80% had Hispanic/Latino ethnicity. Severe underreporting of race and ethnicity precluded much of secondary significance testing across study variables. Conclusions: Females are likely underrepresented in high-quality, US-registered burn trials, unreflective of their real-world disease burden. Further, severe underreporting of race and ethnicity was noted. Future trials should enroll diverse demographics and equitable populations for promotion of study generalizability.

Published
2024
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44. sj-docx-1-tpp-10.1177_20451253231171512 – Supplemental material for Safety and tolerability of intramuscular and sublingual ketamine for psychiatric treatment in the Roots To Thrive ketamine-assisted therapy program: a retrospective chart review

Author

Tsang, Vivian W.L., Tao, Brendan, Dames, Shannon, Walsh, Zach, and Kryskow, Pam

Subjects
FOS: Clinical medicine, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
Abstract

Supplemental material, sj-docx-1-tpp-10.1177_20451253231171512 for Safety and tolerability of intramuscular and sublingual ketamine for psychiatric treatment in the Roots To Thrive ketamine-assisted therapy program: a retrospective chart review by Vivian W.L. Tsang, Brendan Tao, Shannon Dames, Zach Walsh and Pam Kryskow in Therapeutic Advances in Psychopharmacology

Published
2023
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46. Inappropriate Use of the Term 'Papilledema' in the Medical Literature: A Systematic Review of Case Reports Across Specialties

Author

Tao, Brendan

Subjects
Ophthalmology, Medicine and Health Sciences, Medical Specialties, Papilledema, optic disc edema, case report, impact factor, medical specialty, open access
Abstract

Research Question: What is the prevalence of inappropriate use of the term “papilledema” in the literature; and how do authors’ medical specialty, journal impact factor, and open-access journal status influence misuse of this term?

Published
2022
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48. Unspecified psychosis and stimulant drugs: A commentary on current trends.

Author

Tao, Brendan, Bhanot, Saundarai, and Tsang, Vivian W. L.

Subjects
*PSYCHOSES, *STIMULANTS, *SUBSTANCE abuse, *SYMPTOMS, *ANTIPSYCHOTIC agents
Abstract

With the increasing potency of substances in British Columbia and ever-evolving substance use patterns, many British Columbians continue to present to hospitals with unspecified psychosis. It is unclear what portion of these cases is attributable to substance use or medical etiologies rather than a primary psychotic disorder on initial clinical presentation. Stimulants, in particular, account for many substance-induced psychosis cases. Differentiating stimulant-induced psychosis from other etiologies of psychosis in emergency department settings can streamline pharmacotherapy and health management decisions, such as addressing underlying substance use behaviors and using antipsychotic medications to improve patient outcomes. Further, many patients who experience stimulant-induced psychosis are at increased risk of later developing primary psychosis should their substance use continue. Psychoeducational and medical interventions may reduce the possibility of transformation. In this commentary, we discuss stimulant use trends and associated nuances in BC. [ABSTRACT FROM AUTHOR]

Published
2023

49. RHYTHM VERSUS RATE CONTROL IN PATIENTS WITH POSTOPERATIVE ATRIAL FIBRILLATION FOLLOWING CARDIAC SURGERY: A SYSTEMATIC REVIEW AND META-ANALYSIS

Author

Ahmed, Muneeb, primary, Belley-Cote, Emilie, additional, Qiu, Yuan, additional, Belesiotis, Peter, additional, Tao, Brendan, additional, Wolf, Alex, additional, Kaur, Hargun, additional, Ibrahim, Alex, additional, Healey, Jeff S., additional, Conen, David, additional, Devereaux, P.J., additional, Whitlock, Richard, additional, and McIntyre, William F., additional

Published
2022
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