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17. Effects of alpha,beta-unsaturated sulphones and phosphonium salts on ecto-ATPase activity and contractile responses mediated via P2 chi-purinoceptors.

Author

Ziganshin AU, Berdnikov EA, Ziganshina LE, Tantasheva FR, Hoyle CH, and Burnstock G

Subjects
Animals, Cell Membrane drug effects, Cell Membrane enzymology, Guinea Pigs, In Vitro Techniques, Male, Muscle Contraction drug effects, Muscle, Smooth enzymology, Synaptic Transmission drug effects, Urinary Bladder drug effects, Urinary Bladder enzymology, Vas Deferens drug effects, Vas Deferens enzymology, Adenosine Triphosphatases metabolism, Muscle, Smooth drug effects, Organophosphorus Compounds pharmacology, Receptors, Purinergic P2 drug effects, Sulfones pharmacology
Abstract

1. In the guinea-pig urinary bladder and vas deferens, several alpha,beta-unsaturated sulphones and phosphonium salts that were tested inhibited ecto-ATPase activity. The sulphones were more active in the bladder but the phosphonium salts were more effective in the vas deferens. 2. These compounds either potentiated or inhibited purinergic contractile responses in the guinea-pig urinary bladder and vas deferens. 3. alpha,beta-Unsaturated sulphones and phosphonium salts represent a new promising class of compounds, capable of modulating purinergic neurotransmission.

Published
1995
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