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34 results on '"Tansy, Aaron"'

1. CARDINALS: A Phase 2, Randomized, Double-blind, Placebo-controlled, Parallel-group Study to Evaluate the Efficacy and Safety of Utreloxastat (PTC857) in Patients with Amyotrophic Lateral Sclerosis (P5-11.010)

Author

Katz, Jonathan S., primary, Vu, Tuan, additional, Chio, Adriano, additional, McDermott, Christopher, additional, Devos, David, additional, Johnston, Mayzie, additional, Sierra, Rafael, additional, Tansy, Aaron, additional, Trimmer, Jeff, additional, and Shefner, Jeremy M., additional

Published
2024
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2. Hemodynamic Features of Symptomatic Vertebrobasilar Disease

Author

Amin-Hanjani, Sepideh, Du, Xinjian, Rose-Finnell, Linda, Pandey, Dilip K, Richardson, DeJuran, Thulborn, Keith R, Elkind, Mitchell SV, Zipfel, Gregory J, Liebeskind, David S, Silver, Frank L, Kasner, Scott E, Aletich, Victor A, Caplan, Louis R, Derdeyn, Colin P, Gorelick, Philip B, Charbel, Fady T, Xie, Hui, Flannery, Michael P, Ganin, Hagai, Ruland, Sean, Grysiewicz, Rebecca, Khaja, Aslam, Pedelty, Laura, Testai, Fernando, Ong, Archie, Epstein, Noam, Muqtadar, Hurmina, Watson, Karriem, Mlinarevich, Nada, Hillmann, Maureen, Hirsch, Joy, Dashnaw, Stephen, Meyers, Philip M, Willey, Josh Z, McNeill-Simaan, Edwina, Perez, Veronica, Canaan, Alberto, Paulino-Hernandez, Wayna, Vo, Katie, Foster, Glenn, Ford, Andria, Nassief, Abdullah, Bradley, Abbie, Serna-Northway, Jannie, Kraus, Kristi, Shiwani, Lina, Hantler, Nancy, Alger, Jeffrey, Godinez, Sergio, Saver, Jeffrey L, Ali, Latisha, Kim, Doojin, Tenser, Matthew, Froehler, Michael, Raychev, Radoslav, Song, Sarah, Ovbiagele, Bruce, Abcede, Hermelinda, Adamczyk, Peter, Rao, Neal, Yallapragada, Anil, Modir, Royya, Hinman, Jason, Tansy, Aaron, Calderon-Arnulphi, Mateo, Sheth, Sunil, Noorian, Alireza, Ng, Kwan, Liang, Conrad, Gadhia, Jignesh, Smith, Hannah, Avila, Gilda, Avelar, Johanna, Mikulis, David, Fierstra, Jorn, Hlasny, Eugen, Casaubon, Leanne K, Vergouwen, Mervyn, del Campo, JC Martin, Jaigobin, Cheryl S, Astorga, Cherissa, Kalman, Libby, Kramer, Jeffrey, Vaughan, Susan, Owens, Laura, Kissela, Brett, Turan, Tanya N, Jacobs, Tom P, and Janis, Scott

Subjects
Cardiovascular, Neurosciences, Stroke, Clinical Research, Adult, Aged, Aged, 80 and over, Blood Flow Velocity, Cerebrovascular Circulation, Cohort Studies, Female, Hemodynamics, Humans, Male, Middle Aged, Prospective Studies, Risk Factors, Vertebrobasilar Insufficiency, magnetic resonance angiography, magnetic resonance imaging, regional blood flow, stroke, vertebrobasilar ischemia, VERiTAS Study Group, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Neurology & Neurosurgery
Abstract

Background and purposeAtherosclerotic vertebrobasilar disease is an important cause of posterior circulation stroke. To examine the role of hemodynamic compromise, a prospective multicenter study, Vertebrobasilar Flow Evaluation and Risk of Transient Ischemic Attack and Stroke (VERiTAS), was conducted. Here, we report clinical features and vessel flow measurements from the study cohort.MethodsPatients with recent vertebrobasilar transient ischemic attack or stroke and ≥50% atherosclerotic stenosis or occlusion in vertebral or basilar arteries (BA) were enrolled. Large-vessel flow in the vertebrobasilar territory was assessed using quantitative MRA.ResultsThe cohort (n=72; 44% women) had a mean age of 65.6 years; 72% presented with ischemic stroke. Hypertension (93%) and hyperlipidemia (81%) were the most prevalent vascular risk factors. BA flows correlated negatively with percentage stenosis in the affected vessel and positively to the minimal diameter at the stenosis site (P

Published
2015

3. Image More to Save More

Author

Tansy, Aaron P, Hinman, Jason D, Ng, Kwan L, Calderon-Arnulphi, Mateo, Modir, Royya, Chatfield, Fiona, and Liebeskind, David S

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Brain Disorders, Neurosciences, Biomedical Imaging, Prevention, Clinical Trials and Supportive Activities, Clinical Research, Stroke, CT, MRI, stroke systems of care, acute stroke interventions, endovascular therapy, acute stroke, stroke centers, acute stroke imaging, Psychology, Clinical sciences, Biological psychology
Abstract

Recent successful endovascular stroke trials have provided unequivocal support for these therapies in selected patients with large-vessel occlusive acute ischemic stroke. In this piece, we briefly review these trials and their utilization of advanced neuroimaging techniques that played a pivotal role in their success through targeted patient selection. In this context, the unique challenges and opportunity for advancement in current stroke networks' routine delivery of care created by these trials are discussed and recommendations to change current national stroke system guidelines are proposed.

Published
2015

4. The goldilocks dilemma in acute ischemic stroke.

Author

Tansy, Aaron P and Liebeskind, David S

Subjects
endovascular, ischemia, perfusion, stroke, therapy, Clinical Sciences, Neurosciences, Psychology
Abstract

Despite the advent of and exciting advances in novel endovascular therapies, t-PA remains the only proven treatment for acute ischemic stroke to date. Although a variety of reasons likely underlie why past trials of endovascular strategies have been unsuccessful, we address in this perspective piece one critical unknown for which a solution is undoubtedly necessary if future ones are to meet with success: determination and selection of patients that are "just right" for endovascular treatments, or the Goldilocks dilemma. Key clinical criteria highlighted in past trials may help provide a solution to this critical problem. However, for them to do so, we propose that they must be applied in service of a model that accounts for the nuanced, dynamic nature of acute ischemic stroke better than the prevailing "time is brain" model. We provide and examine three clinical cases to illustrate this proposal towards solving the Goldilocks dilemma and advancing treatment in acute ischemic stroke. Further, we address our field's ongoing challenge and mission in the meantime to best care for the "not-so-right" patients, by far the majority of the affected stroke population.

Published
2013

8. First‐in‐Human Studies of Pharmacokinetics and Safety of Utreloxastat (PTC857), a Novel 15‐Lipooxygenase Inhibitor for the Treatment of Amyotrophic Lateral Sclerosis

Author

Gao, Lan, primary, Giannousis, Peter, additional, Thoolen, Martin, additional, Kaushik, Diksha, additional, Latham, Joey, additional, Tansy, Aaron, additional, Ma, Jiyuan, additional, Johnston, Mayzie, additional, Dali, Mandar, additional, Golden, Lee, additional, Klein, Matthew, additional, Kong, Ronald, additional, and Trimmer, Jeffrey, additional

Published
2022
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11. First‐in‐Human Studies of Pharmacokinetics and Safety of Utreloxastat (PTC857), a Novel 15‐Lipooxygenase Inhibitor for the Treatment of Amyotrophic Lateral Sclerosis.

Author

Gao, Lan, Giannousis, Peter, Thoolen, Martin, Kaushik, Diksha, Latham, Joey, Tansy, Aaron, Ma, Jiyuan, Johnston, Mayzie, Dali, Mandar, Golden, Lee, Klein, Matthew, Kong, Ronald, and Trimmer, Jeffrey

Subjects
AMYOTROPHIC lateral sclerosis, PHARMACOKINETICS
Abstract

Utreloxastat (PTC857) is a 15‐lipoxygenase inhibitor being developed to treat amyotrophic lateral sclerosis. This first‐in‐human study investigated the safety and pharmacokinetics of utreloxastat in healthy volunteers (N = 82) in a double‐blind, placebo‐controlled trial. The effects of a single ascending dose (100–1000 mg), multiple ascending doses (150–500 mg), and food (500 mg) on the pharmacokinetics and safety of utreloxastat were evaluated. Following single doses, the time to maximum plasma concentration (Cmax) was observed ≈4 hours after dosing and the terminal half‐life ranged from 20 to 25.3 hours. The Cmax and area under the concentration‐time curve (AUC) increased slightly over dose proportionally. Following multiple doses (once daily/twice daily), the apparent clearance reduced and terminal half‐life was ≥33 hours. There was no apparent difference of exposure following morning or evening doses. Varying diets increased the Cmax and AUCs of utreloxastat but did not alter time to Cmax. There were no gender‐based differences in exposure. Utreloxastat showed no marked safety signal following single doses up to 1000 mg and multiple doses over 14 days of 500 mg once daily or 250 mg twice daily. The results support further development of utreloxastat for the treatment of patients with amyotrophic lateral sclerosis at a 250‐mg twice‐daily dose administered with food. [ABSTRACT FROM AUTHOR]

Published
2023
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14. Optimized Hemodynamic Assessment to Predict Stroke Risk in Vertebrobasilar Disease: Analysis From the VERiTAS Study

Author

See, Alfred P., primary, Pandey, Dilip K., additional, Du, Xinjian, additional, Rose‐Finnell, Linda, additional, Charbel, Fady T., additional, Derdeyn, Colin P., additional, Amin‐Hanjani, Sepideh, additional, Richardson, DeJuran, additional, Xie, Hui, additional, Thulborn, Keith, additional, Flanner, Michael P., additional, Ganin, Hagai, additional, Ruland, Sean, additional, Grysiewicz, Rebecca, additional, Khaja, Aslam, additional, Pedelty, Laura, additional, Testai, Fernando, additional, Ong, Archie, additional, Epstein, Noam, additional, Muqtadar, Hurmina, additional, Watson, Karriem, additional, Mlinarevich, Nada, additional, Hillmann, Maureen, additional, Elkind, Mitchell S. V., additional, Hirsch, Joy, additional, Dashnaw, Stephen, additional, Meyers, Philip M., additional, Willey, Josh Z., additional, McNeill‐Simaan, Edwina, additional, Perez, Veronica, additional, Canaan, Alberto, additional, Paulino‐Hernandez, Wayna, additional, Zipfel, Gregory J., additional, Vo, Katie, additional, Foster, Glenn, additional, Ford, Andria, additional, Nassief, Abdullah, additional, Bradley, Abbie, additional, Serna‐Northway, Jannie, additional, Kraus, Kristi, additional, Shiwani, Lina, additional, Hantler, Nancy, additional, Liebeskind, David S., additional, Alger, Jeffrey, additional, Godinez, Sergio, additional, Saver, Jeffrey L., additional, Ali, Latisha, additional, Kim, Doojin, additional, Tenser, Matthew, additional, Froehler, Michael, additional, Raychev, Radoslav, additional, Song, Sarah, additional, Ovbiagele, Bruce, additional, Abcede, Hermelinda, additional, Adamczyk, Peter, additional, Rao, Neal, additional, Yallapragada, Anil, additional, Modir, Royya, additional, Hinman, Jason, additional, Tansy, Aaron, additional, Calderon‐Arnulphi, Mateo, additional, Sheth, Sunil, additional, Noorian, Alireza, additional, Ng, Kwan, additional, Liang, Conrad, additional, Gadhia, Jignesh, additional, Smith, Hannah, additional, Avila, Gilda, additional, Avelar, Johanna, additional, Silver, Frank L., additional, Mikulis, David, additional, Fierstra, Jorn, additional, Hlasny, Eugen, additional, Casaubon, Leanne K., additional, Vergouwen, Mervyn, additional, Martin del Campo, J. C., additional, Jaigobin, Cheryl S., additional, Astorga, Cherissa, additional, Kalman, Libby, additional, Kramer, Jeffrey, additional, Vaughan, Susan, additional, Owens, Laura, additional, Thulborn, Keith R., additional, Caplan, Louis R., additional, Gorelick, Philip B., additional, Kasner, Scott E., additional, Kissela, Brett, additional, Turan, Tanya N., additional, Aletich, Victor, additional, Jacobs, Tom P., additional, and Janis, Scott, additional

Published
2020
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21. ARPEGGIO: a placebo-controlled trial of oral laquinimod in primary progressive multiple sclerosis (S8.003)

Author

Giovannoni, Gavin, primary, Barkhof, Frederik, additional, Hartung, Hans-Peter, additional, Cree, Bruce, additional, Krieger, Stephen, additional, Montalban, Xavier, additional, Sormani, Maria Pia, additional, Uccelli, Antonio, additional, Uitdehaag, Bernard, additional, Vollmer, Timothy, additional, Reshef, Ayelet, additional, Li, Thomas, additional, Feldman, Peter, additional, Tansy, Aaron, additional, and Steinerman, Joshua, additional

Published
2018
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22. Acute Stroke Multimodal Imaging: Present and Potential Applications toward Advancing Care.

Author

Matos Diaz, Ivan, Liang, John W., Ostojic, L. Velickovic, Tansy, Aaron P., Matos Diaz, Ivan, Liang, John W., Ostojic, L. Velickovic, and Tansy, Aaron P.

Abstract

In the past few decades, the field of acute ischemic stroke (AIS) has experienced significant advances in clinical practice. A core driver of this success has been the utilization of acute stroke imaging with an increasing focus on advanced methods including multimodal imaging. Such imaging techniques not only provide a richer understanding of AIS in vivo, but also, in doing so, provide better informed clinical assessments in management and treatment toward achieving best outcomes. As a result, advanced stroke imaging methods are now a mainstay of routine AIS practice that reflect best practice delivery of care. Furthermore, these imaging methods hold great potential to continue to advance the understanding of AIS and its care in the future. Copyright © 2017 by Thieme Medical Publishers, Inc.

Published
2017

25. Abstract W P47: Recanalization After IV TPA Alone Among Acute Ischemic Stroke Patients Treated With Combined IV-Endovascular Recanalization: Impact of Arterial Occlusion Site

Author

Kim, Seo Hyun, primary, Liebeskind, David, additional, Jahan, Reza, additional, Starkman, Sidney, additional, Ali, Latisha, additional, Rao, Neal, additional, Hinman, Jason, additional, Vespa, Paul, additional, B. Blanco, Manuel, additional, Modir, Royya, additional, Tansy, Aaron, additional, Vinuela, Fernando, additional, Duckwiler, Gary, additional, Tateshima, Satoshi, additional, Gonzalez, Nestor, additional, and Saver, Jeffrey L., additional

Published
2014
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26. Abstract T P33: Collateral Grade on MRI - Validation With Conventional Angiography is Key

Author

Ng, Kwan L, primary, Saver, Jeffrey L, additional, Alger, Jeffry R, additional, Scalzo, Fabien, additional, Salamon, Noriko, additional, Yoo, Bryan, additional, Starkman, Sidney, additional, Ali, Latisha K, additional, Rao, Neal, additional, Hinman, Jason, additional, Calderon-Arnulphi, Mateo, additional, Modir, Royya, additional, Tansy, Aaron, additional, Liang, Conrad W, additional, Sheth, Sunil A, additional, Noorian, Alireza R, additional, Vespa, Paul, additional, Blanco, Manuel B, additional, Jahan, Reza, additional, Vinuela, Fernando, additional, Duckwiler, Gary R, additional, Tateshima, Satoshi, additional, Gonzalez, Nestor, additional, and Liebeskind, David S, additional

Published
2014
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30. Abstract W P47.

Author

Kim, Seo Hyun, Liebeskind, David, Jahan, Reza, Starkman, Sidney, Ali, Latisha, Rao, Neal, Hinman, Jason, Vespa, Paul, B. Blanco, Manuel, Modir, Royya, Tansy, Aaron, Vinuela, Fernando, Duckwiler, Gary, Tateshima, Satoshi, Gonzalez, Nestor, and Saver, Jeffrey L.

Published
2014

31. Abstract T P33.

Author

Ng, Kwan L, Saver, Jeffrey L, Alger, Jeffry R, Scalzo, Fabien, Salamon, Noriko, Yoo, Bryan, Starkman, Sidney, Ali, Latisha K, Rao, Neal, Hinman, Jason, Calderon-Arnulphi, Mateo, Modir, Royya, Tansy, Aaron, Liang, Conrad W, Sheth, Sunil A, Noorian, Alireza R, Vespa, Paul, Blanco, Manuel B, Jahan, Reza, and Vinuela, Fernando

Published
2014

32. Abstract T P29.

Author

Liebeskind, David S, Sanossian, Nerses, Alger, Jeffry R, Qiao, Joe X, Scalzo, Fabien, Johnson, Mark S, Starkman, Sidney, Ali, Latisha K, Kim, Doojin, Rao, Neal M, Hinman, Jason D, Tansy, Aaron P, Calderon-Arnulphi, Mateo, Modir, Royya F, Vespa, Paul M, Blanco, Manuel B, Jahan, Reza, Tateshima, Satoshi, Gonzalez, Nestor R, and Duckwiler, Gary R

Published
2014

33. Abstract W P21.

Author

Liang, Conrad W, Saver, Jeffrey L, Jahan, Reza, Starkman, Sidney, Ali, Latisha K, Rao, Neal, Hinman, Jason D, Vespa, Paul M, Blanco, Manuel B, Modir, Royya F, Tansy, Aaron P, Calderon-Arnulphi, Mateo, Ng, Kwan L, Noorian, Ali R, Sheth, Sunil A, Viñuela, Fernando, Duckwiler, Gary R, Tateshima, Satoshi, Gonzalez, Nestor R, and Liebeskind, David S

Published
2014

34. Abstract W MP19.

Author

Tansy, Aaron P, Scalzo, Fabien, Starkman, Sidney, Ali, Latisha K, Kim, Doojin, Vespa, Paul M, Rao, Neal M, Yallapragada, Anil, Alger, Jeffrey R, Salamon, Noriko, Saver, Jeffrey L, and Liebeskind, David S

Published
2014

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