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717 results on '"Tanner, N"'

1. The homotopy of the KU_G-local equivariant sphere spectrum

Author

Carawan, Tanner N., Field, Rebecca, Guillou, Bertrand J., Mehrle, David, and Stapleton, Nathaniel J.

Subjects
Mathematics - Algebraic Topology
Abstract

We compute the homotopy Mackey functors of the $KU_G$-local equivariant sphere spectrum when $G$ is a finite $q$-group for an odd prime $q$, building on the degree zero case from arXiv:2204.03797., Comment: 15 pages. Comments welcome!

Published
2023
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2. TCTP regulates genotoxic stress and tumorigenicity via intercellular vesicular signaling

Author

Amson, Robert, Senff-Ribeiro, Andrea, Karafin, Teele, Lespagnol, Alexandra, Honoré, Joane, Baylot, Virginie, Banroques, Josette, Tanner, N Kyle, Chamond, Nathalie, Dimitrov, Jordan D, Hoebeke, Johan, Droin, Nathalie M, Job, Bastien, Piard, Jonathan, Bommer, Ulrich-Axel, Choi, Kwang-Wook, Abdelfatah, Sara, Efferth, Thomas, Telerman, Stephanie B, Geyer, Felipe Correa, Reis-Filho, Jorge, and Telerman, Adam

Published
2024
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3. Constrained Volume Micro- and Nanoparticle Collection Methods in Microfluidic Systems

Author

Tanner N. Wells, Holger Schmidt, and Aaron R. Hawkins

Subjects
microfluidics, particle trapping, particle enrichment, cell trapping, particle manipulation, Mechanical engineering and machinery, TJ1-1570
Abstract

Particle trapping and enrichment into confined volumes can be useful in particle processing and analysis. This review is an evaluation of the methods used to trap and enrich particles into constrained volumes in microfluidic and nanofluidic systems. These methods include physical, optical, electrical, magnetic, acoustic, and some hybrid techniques, all capable of locally enhancing nano- and microparticle concentrations on a microscale. Some key qualitative and quantitative comparison points are also explored, illustrating the specific applicability and challenges of each method. A few applications of these types of particle trapping are also discussed, including enhancing biological and chemical sensors, particle washing techniques, and fluid medium exchange systems.

Published
2024
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7. Label-free and amplification-free viral RNA quantification from primate biofluids using a trapping-assisted optofluidic nanopore platform

Author

Sampad, Mohammad Julker Neyen, primary, Saiduzzaman, S. M., additional, Walker, Zach J., additional, Wells, Tanner N., additional, Wayment, Jesse X., additional, Ong, Ephraim M., additional, Mdaki, Stephanie D., additional, Tamhankar, Manasi A., additional, Yuzvinsky, Thomas D., additional, Patterson, Jean L., additional, Hawkins, Aaron R., additional, and Schmidt, Holger, additional

Published
2024
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9. The RNA Helicase Ded1 from Yeast Is Associated with the Signal Recognition Particle and Is Regulated by SRP21.

Author

Yeter-Alat, Hilal, Belgareh-Touzé, Naïma, Le Saux, Agnès, Huvelle, Emmeline, Mokdadi, Molka, Banroques, Josette, and Tanner, N. Kyle

Subjects
RNA helicase, RNA-binding proteins, GENETIC translation, YEAST extract, YEAST, NUCLEOPROTEINS
Abstract

The DEAD-box RNA helicase Ded1 is an essential yeast protein involved in translation initiation that belongs to the DDX3 subfamily. The purified Ded1 protein is an ATP-dependent RNA-binding protein and an RNA-dependent ATPase, but it was previously found to lack substrate specificity and enzymatic regulation. Here we demonstrate through yeast genetics, yeast extract pull-down experiments, in situ localization, and in vitro biochemical approaches that Ded1 is associated with, and regulated by, the signal recognition particle (SRP), which is a universally conserved ribonucleoprotein complex required for the co-translational translocation of polypeptides into the endoplasmic reticulum lumen and membrane. Ded1 is physically associated with SRP components in vivo and in vitro. Ded1 is genetically linked with SRP proteins. Finally, the enzymatic activity of Ded1 is inhibited by SRP21 in the presence of SCR1 RNA. We propose a model where Ded1 actively participates in the translocation of proteins during translation. Our results provide a new understanding of the role of Ded1 during translation. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Assessment of Plasma Proteomics Biomarker’s Ability to Distinguish Benign From Malignant Lung Nodules: Results of the PANOPTIC (Pulmonary Nodule Plasma Proteomic Classifier) Trial

Author

Silvestri, G.A., Leake, L., Mazzone, P., Beukemann, M., Midthun, D., McCarthy, P., Sigal, B., Deluca, T., Laberge, F., Fortin, B., Balaan, M., Dimitt, B., Pierre, A., Allison, F., Yarmus, L., Oakjones-Burgess, K., Tanner, N., Ettinger, N., Setchfield, T., Madtes, D., Hubbard, J., McConnell, W., Robinson, K., Lackey, A., Jacques, L., Kuo, E., Markland-Gentles, V., Massion, P., Muterspaug, A., Leach, J., Rothe, K., Rom, W., Pass, H., Sorenson, A., Chesnutt, A., Georgeson, A., Balekian, A., Fisher, J., Murali, R., Overton, A., Desai, N., Levesque, A., Krimsky, W., King, S., Vachani, A., Maletteri, K., Mileham, K., Carter, L., Hong, G., Ma, J., Voelker, K., Barrentine, H., Aronson, R., Henderson, M., Lamberti, J., Krawiecki, C., Case, A., Wilkins, L., Ayers, J.M., Fangmann, K., Landis, J., DeSouza, L., Hammoud, Z., Kah, D., Sanchez, J., Murdoch, L., Silvestri, Gerard A., Tanner, Nichole T., Kearney, Paul, Vachani, Anil, Massion, Pierre P., Porter, Alexander, Springmeyer, Steven C., Fang, Kenneth C., Midthun, David, and Mazzone, Peter J.

Published
2018
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16. 'Stick with Yourselves; It's What's Normal': The Intergroup Racial Attitudes of Senior, White, Fraternity Men

Author

Morgan, Demetri L., Zimmerman, Hilary B., Terrell, Tanner N., and Marcotte, Beth A.

Abstract

Substantive cross-racial interaction on college campuses has been known to have positive effects on student learning and development (Chang, Astin, & Kim, 2004). However, literature shows that students from different minoritized racial groups often remain separated from majority White groups, such as fraternities, thus prohibiting each group to realize the benefits such interaction could offer (Sidanius, Laar, Levin, & Sinclair, 2004). Utilizing focus group methods, this study investigated the racial attitudes of 20 senior, White, Interfraternity Council men in order to better show how the fraternity culture and experience influence the racial attitudes of members. This study found four themes that help illuminate how racist attitudes are formed and reproduced in these organizations. The implications of this study are useful for student affairs professionals concerned with the ways in which racial dynamics on predominantly White campuses affect the campus climate for diversity and the character development of students.

Published
2015
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17. The Sudbury Neutrino Observatory

Author

Norman, E B, Chan, Y D, Garcia, A, Lesko, K T, Smith, A R, Stokstad, R G, Zlimen, I, Evans, H C, Ewan, G T, Hallin, A, Lee, H W, Leslie, J R, MacArthur, J D, Mak, H B, McDonald, A B, McLatchie, W, Robertson, B C, Skensved, P, Sur, B, Bonvin, E, Earle, B D, Hepburn, D, Milton, G M, Blevis, I, Davidson, W F, Hargrove, C K, Mes, H, Shatkay, M, Sinclair, D, Carter, A L, Hollebone, B, Kessler, D, Jagam, P, Law, J, Ollerhead, R W, Simpson, J J, Wang, J X, Bigu, J, Hallman, E D, Haq, R U, Virtue, C, Gil, S, Waltham, C, Lowry, M M, Beier, E W, Frati, W, Newcomer, M, Van Berg, R, Bowles, T J, Doe, P, Fowler, M M, Hime, A, McGirt, F, Robertson, R G H, Spencer, T C, Vieira, D J, Wilhemy, J B, Wilkerson, J F, Wouters, J M, Tanner, N W, Jelley, N A, Barton, J C, Doucas, G, Hooper, E W, Knox, A B, Moorhead, M E, Omori, M, Trent, P T, and Wark, D L

Published
1992

18. Enzymatic and Molecular Characterization of Anti-Leishmania Molecules That Differently Target Leishmania and Mammalian eIF4A Proteins, LieIF4A and eIF4AMus

Author

Abdelkrim, Yosser Zina, primary, Harigua-Souiai, Emna, additional, Bassoumi-Jamoussi, Imen, additional, Barhoumi, Mourad, additional, Banroques, Josette, additional, Essafi-Benkhadir, Khadija, additional, Nilges, Michael, additional, Blondel, Arnaud, additional, Tanner, N. Kyle, additional, and Guizani, Ikram, additional

Published
2022
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20. Effectiveness of a brief group intervention program for young adults with gaming-related problems

Author

Männikkö, N. (Niko), Mustonen, T. (Terhi), Tanner, N. (Niina), Vähänikkilä, H. (Hannu), Kääriäinen, M. (Maria), Männikkö, N. (Niko), Mustonen, T. (Terhi), Tanner, N. (Niina), Vähänikkilä, H. (Hannu), and Kääriäinen, M. (Maria)

Abstract

Excessive digital gaming can have unfavorable effects on gamers’ well-being and everyday functioning. The aims of this study were to investigate the effects of a novel group intervention “Limitless Gaming Bootcamp” on (i) gaming disorder (GD) tendencies, (ii) the amount of time spent on leisure activities, and (iii) subjective well-being among Finnish young adults, and to determine the persistence of the intervention’s influence over time. A one-group pre- and post-test design with no control group was used. Thirty-seven participants were enrolled in the study. The inclusion criteria were being between the ages of 18 and 29; self-reported excessive gaming; a willingness to get support in monitoring one’s gaming behaviour; and a fluency in Finnish. Participants completed a 10-session group intervention designed to enhance conscious gaming behavior and well-being. Baseline, post-test, and six month follow-up measurements were conducted to gather data. Variables measured included background variables, gaming disorder tendencies (Problematic Online Gaming Questionnaire, POGQ), self-reported time spent on various leisure activities, and subjective well-being (Short Form of the Clinical Outcomes in Routine Evaluation Outcome Measure, CORE-SF/A). The time spent on gaming decreased from pre- to post-intervention measurement and further to the six month follow-up, and participants exhibited less severe GD symptoms during the post-intervention phase and six months after the intervention. Gradual improvements in subjective well-being were also observed. The group intervention was found to be particularly effective at reducing the severity of GD symptoms.

Published
2022

23. Cost‐effectiveness of emergency versus delayed laparoscopic cholecystectomy for acute gallbladder pathology

Author

Sutton, A. J., Vohra, R. S., Hollyman, M., Marriott, P. J., Buja, A., Alderson, D., Pasquali, S., Griffiths, E. A., Vohra, R. S., Spreadborough, P., Hollyman, M., Marriott, P. J., Kirkham, A., Pasquali, S., Alderson, D., Griffiths, E. A., Fenwick, S., Elmasry, M., Nunes, Q. M., Kennedy, D., Khan, R. B., Khan, M. A. S., Magee, C. J., Jones, S. M., Mason, D., Parappally, C. P., Mathur, P., Saunders, M., Jamel, S., Ul Haque, S., Zafar, S., Shiwani, M. H., Samuel, N., Dar, F., Jackson, A., Lovett, B., Dindyal, S., Winter, H., Fletcher, T., Rahman, S., Wheatley, K., Nieto, T., Ayaani, S., Youssef, H., Nijjar, R. S., Watkin, H., Naumann, D., Emesih, S., Sarmah, P. B., Lee, K., Joji, N., Heath, J., Teasdale, R. L., Weerasinghe, C., Needham, P. J., Welbourn, H., Forster, L., Finch, D., Blazeby, J. M., Robb, W., McNair, A. G. K., Hrycaiczuk, A., Charalabopoulos, A., Kadirkamanathan, S., Tang, C.‐B., Jayanthi, N. V. G., Noor, N., Dobbins, B., Cockbain, A. J., Nilsen‐Nunn, A., de Siqueira, J., Pellen, M., Cowley, J. B., Ho, W.‐M., Miu, V., White, T. J., Hodgkins, K. A., Kinghorn, A., Tutton, M. G., Al‐Abed, Y. A., Menzies, D., Ahmad, A., Reed, J., Khan, S., Monk, D., Vitone, L. J., Murtaza, G., Joel, A., Brennan, S., Shier, D., Zhang, C., Yoganathan, T., Robinson, S. J., McCallum, I. J. D., Jones, M. J., Elsayed, M., Tuck, E., Wayman, J., Carney, K., Aroori, S., Hosie, K. B., Kimble, A., Bunting, D.M., Fawole, A. S., Basheer, M., Dave, R. V., Sarveswaran, J., Jones, E., Kendal, C., Tilston, M. P., Gough, M., Wallace, T., Singh, S., Downing, J., Mockford, K. A., Issa, E., Shah, N., Chauhan, N., Wilson, T. R., Forouzanfar, A., Wild, J. R. L., Nofal, E., Bunnell, C., Madbak, K., Rao, S. T. V., Devoto, L., Siddiqi, N., Khawaja, Z., Hewes, J. C., Gould, L., Chambers, A., Rodriguez, D. U., Sen, G., Robinson, S., Carney, K., Bartlett, F., Rae, D. M., Stevenson, T. E. J., Sarvananthan, K., Dwerryhouse, S. J., Higgs, S. M., Old, O. J., Hardy, T. J., Shah, R., Hornby, S. T., Keogh, K., Frank, L., Al‐Akash, M., Upchurch, E. A., Frame, R. J., Hughes, M., Jelley, C., Weaver, S., Roy, S., Sillo, T. O., Galanopoulos, G., Cuming, T., Cunha, P., Tayeh, S., Kaptanis, S., Heshaishi, M., Eisawi, A., Abayomi, M., Ngu, W. S., Fleming, K., Bajwa, D. S., Chitre, V., Aryal, K., Ferris, P., Silva, M., Lammy, S., Mohamed, S., Khawaja, A., Hussain, A., Ghazanfar, M. A., Bellini, M. I., Ebdewi, H., Elshaer, M., Gravante, G., Drake, B., Ogedegbe, A., Mukherjee, D., Arhi, C., Iqbal, L. G. N., Watson, N. F., Aggarwal, S. K., Orchard, P., Villatoro, E., Willson, P. D., Mok, J., Woodman, T., Deguara, J., Garcea, G., Babu, B. I., Dennison, A. R., Malde, D., Lloyd, D., Satheesan, S., Al‐Taan, O., Boddy, A., Slavin, J. P., Jones, R. P., Ballance, L., Gerakopoulos, S., Jambulingam, P., Mansour, S., Sakai, N., Acharya, V., Sadat, M. M., Karim, L., Larkin, D., Amin, K., Khan, A., Law, J., Jamdar, S., Smith, S. R., Sampat, K., Oʼshea, K. M., Manu, M., Asprou, F. M., Malik, N. S., Chang, J., Johnstone, M., Lewis, M., Roberts, G. P., Karavadra, B., Photi, E., Hewes, J., Gould, L., Chambers, A., Rodriguez, D., OʼReilly, D. A., Rate, A. J., Sekhar, H., Henderson, L. T., Starmer, B. Z., Coe, P. O., Tolofari, S., Barrie, J., Bashir, G., Sloane, J., Madanipour, S., Halkias, C., Trevatt, A. E. J., Borowski, D. W., Hornsby, J., Courtney, M. J., Virupaksha, S., Seymour, K., Robinson, S., Hawkins, H., Bawa, S., Gallagher, P. V., Reid, A., Wood, P., Finch, J. G., Parmar, J., Stirland, E., Gardner‐Thorpe, J., Al‐Muhktar, A., Peterson, M., Majeed, A., Bajwa, F. M., Martin, J., Choy, A., Tsang, A., Pore, N., Andrew, D. R., Al‐Khyatt, W., Taylor, C., Bhandari, S., Chambers, A., Subramanium, D., Toh, S. K. C., Carter, N. C., Tate, S., Pearce, B., Wainwright, D., Mercer, S. J., Knight, B., Vijay, V., Alagaratnam, S., Sinha, S., Khan, S., El‐Hasani, S. S., Hussain, A. A., Bhattacharya, V., Kansal, N., Fasih, T., Jackson, C., Siddiqui, M. N., Chishti, I. A., Fordham, I. J., Siddiqui, Z., Bausbacher, H., Geogloma, I., Gurung, K., Tsavellas, G., Basynat, P., Shrestha, A. K., Basu, S., Mohan, A. C., Harilingam, M., Rabie, M., Akhtar, M., Kumar, P., Jafferbhoy, S. F., Hussain, N., Raza, S., Haque, M., Alam, I., Aseem, R., Patel, S., Asad, M., Booth, M. I., Ball, W. R., Wood, C. P. J., Pinho‐Gomes, A. C., Kausar, A., Obeidallah, M. R., Varghase, J., Lodhia, J., Bradley, D., Rengifo, C., Lindsay, D., Gopalswamy, S., Finlay, I., Wardle, S., Bullen, N., Iftikhar, S. Y., Awan, A., Ahmed, J., Leeder, P., Fusai, G., Bond‐Smith, G., Psica, A., Puri, Y., Hou, D., Noble, F., Szentpali, K., Broadhurst, J., Date, R., Hossack, M. R., Goh, Y. L., Turner, P., Shetty, V., Riera, M., Macano, C. A.W., Sukha, A., Preston, S. R., Hoban, J. R., Puntis, D. J., Williams, S. V., Krysztopik, R., Kynaston, J., Batt, J., Doe, M., Goscimski, A., Jones, G. H., Smith, S. R., Hall, C., Carty, N., Ahmed, J., Panteleimonitis, S., Gunasekera, R. T., Sheel, A. R. G., Lennon, H., Hindley, C., Reddy, M., Kenny, R., Elkheir, N., McGlone, E. R., Rajaganeshan, R., Hancorn, K., Hargreaves, A., Prasad, R., Longbotham, D. A., Vijayanand, D., Wijetunga, I., Ziprin, P., Nicolay, C. R., Yeldham, G., Read, E., Gossage, J. A., Rolph, R. C., Ebied, H., Phull, M., Khan, M. A., Popplewell, M., Kyriakidis, D., Hussain, A., Henley, N., Packer, J. R., Derbyshire, L., Porter, J., Appleton, S., Farouk, M., Basra, M., Jennings, N. A., Ali, S., Kanakala, V., Ali, H., Lane, R., Dickson‐Lowe, R., Zarsadias, P., Mirza, D., Puig, S., Al Amari, K., Vijayan, D., Sutcliffe, R., Marudanayagam, R., Hamady, Z., Prasad, A. R., Patel, A., Durkin, D., Kaur, P., Bowen, L., Byrne, J. P., Pearson, K. L., Delisle, T. G., Davies, J., Tomlinson, M. A., Johnpulle, M. A., Slawinski, C., Macdonald, A., Nicholson, J., Newton, K., Mbuvi, J., Farooq, A., Mothe, B. S., Zafrani, Z., Brett, D., Francombe, J., Spreadborough, P., Barnes, J., Cheung, M., Al‐Bahrani, A. Z., Preziosi, G., Urbonas, T., Alberts, J., Mallik, M., Patel, K., Segaran, A., Doulias, T., Sufi, P. A., Yao, C., Pollock, S., Manzelli, A., Wajed, S., Kourkulos, M., Pezzuto, R., Wadley, M., Hamilton, E., Jaunoo, S., Padwick, R., Sayegh, M., Newton, R. C., Hebbar, M., Farag, S. F., Spearman, J., Hamdan, M. F., DʼCosta, C., Blane, C., Giles, M., Peter, M. B., Hirst, N. A., Hossain, T., Pannu, A., El‐Dhuwaib, Y., Morrison, T. E. M., Taylor, G. W., Thompson, R. L. E., McCune, K., Loughlin, P., Lawther, R., Byrnes, C. K., Simpson, D. J., Mawhinney, A., Warren, C., McKay, D., McIlmunn, C., Martin, S., MacArtney, M., Diamond, T., Davey, P., Jones, C., Clements, J.M., Digney, R., Chan, W. M., McCain, S., Gull, S., Janeczko, A., Dorrian, E., Harris, A., Dawson, S., Johnston, D., McAree, B., Ghareeb, E., Thomas, G., Connelly, M., McKenzie, S., Cieplucha, K., Spence, G., Campbell, W., Hooks, G., Bradley, N., Hill, A. D. K., Cassidy, J. T., Boland, M., Burke, P., Nally, D. M., Hill, A. D. K., Khogali, E., Shabo, W., Iskandar, E., McEntee, G. P., OʼNeill, M. A., Peirce, C., Lyons, E. M., OʼSullivan, A. W., Thakkar, R., Carroll, P., Ivanovski, I., Balfe, P., Lee, M., Winter, D. C., Kelly, M. E., Hoti, E., Maguire, D., Karunakaran, P., Geoghegan, J. G., McDermott, F., Martin, S. T., Cross, K. S., Cooke, F., Zeeshan, S., Murphy, J. O., Mealy, K., Mohan, H. M., Nedujchelyn, Y., Ullah, M. F., Ahmed, I., Giovinazzo, F., Milburn, J., Prince, S., Brooke, E., Buchan, J., Khalil, A. M., Vaughan, E. M., Ramage, M. I., Aldridge, R. C., Gibson, S., Nicholson, G. A., Vass, D. G., Grant, A. J., Holroyd, D. J., Jones, M. A., Sutton, C. M. L. R., OʼDwyer, P., Nilsson, F., Weber, B., Williamson, T. K., Lalla, K., Bryant, A., Carter, C. R., Forrest, C. R., Hunter, D. I., Nassar, A. H., Orizu, M. N., Knight, K., Qandeel, H., Suttie, S., Belding, R., McClarey, A., Boyd, A. T., Guthrie, G. J. K., Lim, P. J., Luhmann, A., Watson, A. J. M., Richards, C. H., Nicol, L., Madurska, M., Harrison, E., Boyce, K. M., Roebuck, A., Ferguson, G., Pati, P., Wilson, M. S. J., Dalgaty, F., Fothergill, L., Driscoll, P. J., Mozolowski, K. L., Banwell, V., Bennett, S. P., Rogers, P. N., Skelly, B. L., Rutherford, C. L., Mirza, A. K., Lazim, T., Lim, H. C. C., Duke, D., Ahmed, T., Beasley, W. D., Wilkinson, M. D., Maharaj, G., Malcolm, C., Brown, T. H., Shingler, G. M., Mowbray, N., Radwan, R., Morcous, P., Wood, S., Kadhim, A., Stewart, D. J., Baker, A. L., Tanner, N., Shenoy, H., Hafiz, S., De Marchi, J. A., Singh‐Ranger, D., Hisham, E., Ainley, P., OʼNeill, S., Terrace, J., Napetti, S., Hopwood, B., Rhys, T., Downing, J., Kanavati, O., Coats, M., Aleksandrov, D., Kallaway, C., Yahya, S., Weber, B., Templeton, A., Trotter, M., Lo, C., Dhillon, A., Heywood, N., Aawsaj, Y., Hamdan, A., Reece‐Bolton, O., McGuigan, A., Shahin, Y., Ali, A., Luther, A., Nicholson, J. A., Rajendran, I., Boal, M., and Ritchie, J.

Published
2017
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25. Predicting the difficult laparoscopic cholecystectomy: development and validation of a pre-operative risk score using an objective operative difficulty grading system

Author

Nassar, A. H. M., Hodson, J., H. J., Ng, Vohra, R. S., Katbeh, T., Zino, S., Griffiths, E. A., Kirkham, A. J., Pasquali, S., Marriott, P., Johnstone, M., Spreadborough, P., Alderson, D., Fenwick, S., Elmasry, M., Nunes, Q. M., Kennedy, D., Khan, R. B., Khan, M. A. S., Magee, C. J., Jones, S. M., Mason, D., Parappally, C. P., Mathur, P., Saunders, M., Jamel, S., Haque, S. U., Zafar, S., Shiwani, M. H., Samuel, N., Dar, F., Jackson, A., Lovett, B., Dindyal, S., Winter, H., Fletcher, T., Rahman, S., Wheatley, K., Nieto, T., Ayaani, S., Youssef, H., Nijjar, R. S., Watkin, H., Naumann, D., Emesih, S., Sarmah, P. B., Lee, K., Joji, N., Lambert, J., Heath, J., Teasdale, R. L., Weerasinghe, C., Needham, P. J., Welbourn, H., Forster, L., Finch, D., Blazeby, J. M., Robb, W., Mcnair, A. G. K., Hrycaiczuk, A., Charalabopoulos, A., Kadirkamanathan, S., Tang, C. -B., Jayanthi, N. V. G., Noor, N., Dobbins, B., Cockbain, A. J., Nilsen-Nunn, A., de Siqueira, J., Pellen, M., Cowley, J. B., W. -M., Ho, Miu, V., White, T. J., Hodgkins, K. A., Kinghorn, A., Tutton, M. G., Al-Abed, Y. A., Menzies, D., Ahmad, A., Reed, J., Khan, S., Monk, D., Vitone, L. J., Murtaza, G., Joel, A., Brennan, S., Shier, D., Zhang, C., Yoganathan, T., Robinson, S. J., Mccallum, I. J. D., Jones, M. J., Elsayed, M., Tuck, L., Wayman, J., Carney, K., Aroori, S., Hosie, K. B., Kimble, A., Bunting, D. M., Fawole, A. S., Basheer, M., Dave, R. V., Sarveswaran, J., Jones, E., Kendal, C., Tilston, M. P., Gough, M., Wallace, T., Singh, S., Mockford, J. D. K. A., Issa, E., Shah, N., Chauhan, N., Wilson, T. R., Forouzanfar, A., Wild, J. R. L., Nofal, E., Bunnell, C., Madbak, K., Rao, S. T. V., Devoto, L., Siddiqi, N., Khawaja, Z., Hewes, J. C., Gould, L., Chambers, A., Rodriguez, D. U., Sen, G., Robinson, S., Bartlett, F., Rae, D. M., Stevenson, T. E. J., Sarvananthan, K., Dwerryhouse, S. J., Higgs, S. M., Old, O. J., Hardy, T. J., Shah, R., Hornby, S. T., Keogh, K., Frank, L., Al-Akash, M., Upchurch, E. 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R., Rajaganeshan, R., Hancorn, K., Hargreaves, A., Prasad, R., Longbotham, D. A., Vijayanand, D., Wijetunga, I., Ziprin, P., Nicolay, C. R., Yeldham, G., Read, E., Gossage, J. A., Rolph, R. C., Ebied, H., Phull, M., Khan, M. A., Popplewell, M., Kyriakidis, D., Henley, N., Packer, J. R., Derbyshire, L., Porter, J., Appleton, S., Farouk, M., Basra, M., Jennings, N. A., Ali, S., Kanakala, V., Ali, H., Lane, R., Dickson-Lowe, R., Zarsadias, P., Mirza, D., Puig, S., Al Amari, K., Vijayan, D., Sutcliffe, R., Marudanayagam, R., Hamady, Z., Prasad, A. R., Patel, A., Durkin, D., Kaur, P., Bowen, L., Byrne, J. P., Pearson, K. L., Delisle, T. G., Davies, J., Tomlinson, M. A., Johnpulle, M. A., Slawinski, C., Macdonald, A., Nicholson, J., Newton, K., Mbuvi, J., Farooq, A., Mothe, B. S., Zafrani, Z., Brett, D., Francombe, J., Barnes, J., Cheung, M., Al-Bahrani, A. Z., Preziosi, G., Urbonas, T., Alberts, J., Mallik, M., Patel, K., Segaran, A., Doulias, T., Sufi, P. A., Yao, C., Pollock, S., Manzelli, A., Wajed, S., Kourkulos, M., Pezzuto, R., Wadley, M., Hamilton, E., Jaunoo, S., Padwick, R., Sayegh, M., Newton, R. C., Hebbar, M., Farag, S. F., Spearman, J., Hamdan, M. F., D'Costa, C., Blane, C., Giles, M., Peter, M. B., Hirst, N. A., Hossain, T., Pannu, A., El-Dhuwaib, Y., Morrison, T. E. M., Taylor, G. W., Thompson, R. L. E., Mccune, K., Loughlin, P., Lawther, R., Byrnes, C. K., Simpson, D. J., Mawhinney, A., Warren, C., Mckay, D., Mcilmunn, C., Martin, S., Macartney, M., Diamond, T., Davey, P., Jones, C., Clements, J. M., Digney, R., Chan, W. M., Mccain, S., Gull, S., Janeczko, A., Dorrian, E., Harris, A., Dawson, S., Johnston, D., Mcaree, B., Ghareeb, E., Thomas, G., Connelly, M., Mckenzie, S., Cieplucha, K., Spence, G., Campbell, W., Hooks, G., Bradley, N., Hill, A. D. K., Cassidy, J. T., Boland, M., Burke, P., Nally, D. M., Khogali, E., Shabo, W., Iskandar, E., Mcentee, G. P., O'Neill, M. A., Peirce, C., Lyons, E. M., O'Sullivan, A. 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Subjects
Adult, Male, operative difficulty, medicine.medical_specialty, medicine.medical_treatment, Difficulty grading, difficult cholecystectomy, predictive score, surgery, laparoscopic, cholecystectomy, Surgical planning, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Preoperative Care, Humans, Medicine, Laparoscopic cholecystectomy, Framingham Risk Score, business.industry, General surgery, Reproducibility of Results, Middle Aged, medicine.disease, Pre operative, Single surgeon, Cholecystectomy, Laparoscopic, ROC Curve, 030220 oncology & carcinogenesis, Multivariate Analysis, Cholecystitis, Female, 030211 gastroenterology & hepatology, Surgery, Cholecystectomy, business, Abdominal surgery
Abstract

The prediction of a difficult cholecystectomy has traditionally been based on certain pre-operative clinical and imaging factors. Most of the previous literature reported small patient cohorts and have not used an objective measure of operative difficulty. The aim of this study was to develop a pre-operative score to predict difficult cholecystectomy, as defined by a validated intra-operative difficulty grading scale. Two cohorts from prospectively maintained databases of patients who underwent laparoscopic cholecystectomy were analysed: the CholeS Study (8755 patients) and a single surgeon series (4089 patients). Factors potentially predictive of difficulty were correlated to the Nassar intra-operative difficulty scale. A multivariable binary logistic regression analysis was then used to identify factors that were independently associated with difficult laparoscopic cholecystectomy, defined as operative difficulty grades 3 to 5. The resulting model was then converted to a risk score, and validated on both internal and external datasets. Increasing age and ASA classification, male gender, diagnosis of CBD stone or cholecystitis, thick-walled gallbladders, CBD dilation, use of pre-operative ERCP and non-elective operations were found to be significant independent predictors of difficult cases. A risk score based on these factors returned an area under the ROC curve of 0.789 (95% CI 0.773–0.806, p

Published
2019
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31. A multicentre cohort study assessing day of week effect and outcome from emergency appendicectomy

Author

Ferguson, Henry JM, Hall, Nigel J, Bhangu, Aneel, Panagiotopoulou, I G, Chatzizacharias, N, Rana, M, Rollins, K, Ejtehadi, F, Jha, B, Tan, Y W, Fanous, N, Markides, G, Tan, A, Marshal, C, Akhtar, S, Mullassery, D, Ismail, A, Hitchins, C, Sharif, S, Osborne, L, Sengupta, N, Challand, C, Pournaras, D, Bevan, K, King, J, Massey, J, Sandhu, I, Wells, J M, Teichmann, D A, Peckham-Cooper, A, Sellers, M, Folaranmi, S E, Davies, B, Potter, S, Egbeare, D, Kallaway, C, Parsons, S, Upchurch, E, Lazaridis, A, Cocker, D, King, D, Behar, N, Loukogeorgakis, S P, Kalaiselvan, R, Marzouk, S, Turner, E J H, Kaptanis, S, Kaur, V, Shingler, G, Bennett, A, Shaikh, S, Aly, M, Coad, J, Khong, T, Nouman, Z, Crawford, J, Szatmary, P, West, H, Lambert, J, Gash, K, Hanks, K A, Griggs, E, Humphreys, L, Torrance, A, Hardman, J, Taylor, L, Rex, D, Bennett, J, Crowther, N, McAree, B, Flexer, S, Mistry, P, Jain, P, Hwang, M, Oswald, N, Wells, A, Newsome, H, Martinez, P, Alvarez, C A B, León, J, Carradice, D, Gohil, R, Mount, M, Campbell, A, Iype, S, Dyson, E, Groot-Wassink, T, Ross, A R, Jones, C, Charlesworth, P, Baylem, N, Voll, J, Sian, T, Creedon, L, Hicks, G, Goring, J, Ng, V, Tiboni, S, Palser, T, Rees, B, Ravindra, P, Neophytou, C, Dent, H, Lo, T, Broom, L, OʼConnell, M, Foulkes, R, Griffith, D, Butcher, K, Mclaren, O, Tai, A, Yano, H, Torrance, H D T, Moussa, O, Mittapalli, D, Watt, D, Basson, S, Gilliland, J, Pilgrim, S, Wilkins, A, Yee, J, Cain, H, Wilson, M, Pearson, J, Turnbull, E, Brigic, A, Yassin, N A, Clarke, J, Mallappa, S, Jackson, P, Jones, C, Lakshminarayanan, B, Sharma, A, Velineni, R, Fareed, K, Yip, G, Brown, A, Patel, N, Ghisel, M, Tanner, N, Jones, H, Witherspoon, J, Phillips, M, Ho, M F, Ng, S, Mak, T, Campain, N, Mukhey, D, Mitchell, W K, Amawi, F, Dickson, E, Aggarwal, S, Satherley, L K, Asprou, F, Keys, C, Steven, M, Johnstone, M, Muhlschlegel, J, Hamilton, E, Yin, J, Dilworth, M, Wright, A, Spreadborough, P, Singh, M, Mockford, K, Morgan, J, Ball, W, Royle, J, Lacy-Colson, J, Lai, W, Griffiths, S, Mitchell, S, Parsons, C, Joel, A S, Mason, P F, Harrison, G J, Steinke, J, Rafique, H, Battersby, C, Hawkins, W, Gurram, D, Hateley, C A, Penkethman, A, Lambden, C, Conway, A, Dent, P, Yacob, D, Oshin, O A, Hargreaves, A, Gossedge, G, Long, J, Walls, M, Futaba, K, Pinkney, T, Puig, S, Boddy, A, Jones, A, Tennuci, C, Battersby, N, Wilkin, R, Lloyd, C, Sein, E, McEvoy, K, Whisker, L, Austin, S, Colori, A, Sinclair, P, Loughran, M, Lawrence, A, Horsnell, J, Bagenal, J, Pisesky, A, Mastoridis, S, Solanki, K, Siddiq, I, Merker, L, Sarmah, P, Richardson, C, Hanratty, D, Evans, L, Mortimer, M, Bhalla, A, Bartlett, D, Beral, D, Blencowe, N S, Cornish, J, Haddow, J B, Hall, N J, Johnstone, M, Pilgrim, S, Strong, S, Velineni, R, Marriot, P, Vohra, R, Patel, A, Poon, H, and Hepburn, E

Published
2014
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32. Outcomes of obstructed abdominal wall hernia: results from the UK national small bowel obstruction audit

Author

Lee, MJ, Drake, TM, Sayers, AE, Walsh, CJ, Davies, MM, Fearnhead, NS, Abercrombie, J, Acheson, A, Alderson, D, Anderson, I, Bach, S, Davies, M, Hamady, Z, Hind, D, Hollyman, M, Hare, S, Lee, E, Northover, J, Lewis, C, Marriott, P, Maynard, N, Murray, D, Tierney, G, Verjee, A, Wild, J, Abbott, S, Abdulaal, Y, Afshar, S, Ah‐Chuen, J, Ahmed, T, Akhtar, M, Akram, F, Aldred, E, Ali, A, Aly, M, Amajuoyi, A, Amin, V, Anderson, D, Anderson, O, Andreou, A, Ansari, A, Appleton, S, Ardley, R, Arshad, F, Ashour, O, Asour, A, Athem, A, Athersmith, M, Ayoub, F, Azeem, H, Azhar, B, Badenoch, T, Baillie, C, Bandyopadhyay, D, Barker, J, Barker, S, Barkham, B, Baron, R, Barrie, J, Barry‐Yarrow, E, Bashir, G, Battersby, N, Bazoua, G, Behar, N, Bellam, S, Berger, C, Bhandari, S, Bhasin, S, Biggs, S, Bisset, C, Blake, L, Blencowe, N, Boam, T, Boddy, A, Boereboom, C, Bogdan, M, Bogle, R, Bohra, P, Boland, M, Bolkan, H, Borg, C, Boulton, R, Bouras, G, Boyer, M, Boyle, J, Branagan, G, Brewer, H, Briggs, C, Broadhurst, J, Brown, E, Brown, J, Brown, L, Brown, O, Burns, K, Butcher, K, Butler, M, Byrne, B, Campbell, L, Capper, C, Cartmell, M, Cash, T, Chan, S, Chandratreya, N, Chapman, J, Chapman, S, Charalabopoulos, A, Cheek, C, Chok, S, Choong, W, Chow, M, Chowdhury, J, Coe, P, Conaghan, P, Conn, G, Cook, N, Cook, T, Cooper, S, Cornish, J, Cotton, D, Cox, C, Coyne, P, Crook, R, Crozier, J, Cuffolo, G, Cunha, P, Curtis, N, Cutting, J, Da Costa, K, Silva, L, Das, B, Davenport, M, Davies, J, Davies, T, Day, A, Dayal, S, Dean, S, Demetriou, G, Dengu, F, Dennis, R, Dent, H, Dent, P, Deputy, M, Devoto, L, Di Benedetto, G, Dindyal, S, Donnelly, E, Doody, P, Douka, E, Downham, C, Dowson, H, Edent, H, Edgerton, K, Ekpete, N, El Farran, M, Elamin, O, Eljaafari, M, Elsaid, N, El‐Sharif, M, Evans, J, Evans, M, Ewe, R, Ewing, A, Exarchou, K, Fallaize, R, Faoury, M, Farag, S, Farinella, E, Faulkner, G, Ferguson, H, Fisher, O, Fletcher, J, Forouzanfar, A, Foster, A, Fox, R, Francis, N, Fretwell, V, Fung, D, Gammeri, E, Garnham, J, Geraghty, A, Gilbert, A, Gill, C, Gill, M, Gillespie, M, Giordano, P, Glasbey, J, Goh, M, Golder, A, Green, N, Gregoir, T, Grey, T, Groundwater, E, Grove, T, Growcott, S, Gunasekaran, S, Habib, H, Haddow, J, Halahakoon, V, Halkias, C, Hall, C, Hampson, A, Hancock, L, Hanna, T, Hannay, J, Harikrishnan, A, Harries, R, Harris, G, Hartley, J, Harvey, K, Hawkin, P, Hawkins, J, Healy, R, Heard, R, Heartshorne, R, Heller, S, Hendra, L, Herrod, P, Heywood, N, Hicks, G, Hobson, B, Holtham, S, Hope, C, Hopley, P, Hossain, T, Hossaini, S, Howse, F, Hubbard, T, Humphreys, A, Ikram, H, Ioannis, M, Iqbal, M, Iqbal, N, Jain, R, Jatania, J, Jenkinson, P, Jokhan, S, Jones, A, Jones, C, Jones, L, Joshi, H, Joshi, K, Joy, M, Jull, P, Kakaniaris, G, Kallam, R, Kane, E, Kang, P, Kanitkar, R, Kauser, S, Kazmi, F, Kedrzycki, M, Kelly, S, Kendall, J, Khan, M, Khan, T, King, G, Kisiel, A, Kitsis, C, Kolawole, I, Korambayil, S, Kosasih, S, Kosti, A, Kotb, A, Kouris, S, Kshatriya, K, Kumar, S, Lafaurie, G, Lal, R, Lau, A, Lazim, T, Lazzaro, A, Lee, K, Lefroy, R, Leinhardt, D, Lennon, H, Leong, K, Levy, B, Lim, E, Lim, J, Lindley, S, Liu, D, Lloyd, P, Locker, D, Lockwood, S, Lowe, C, Lund, J, Lunevicius, R, Lunt, A, Lutfi, S, Luther, A, Luwemba, S, Mahankali‐Rao, P, Mahroof, S, Mai, D, Majid, S, Malik, A, Malik, K, Mann, K, Mansour, S, Manu, N, Mapara, R, Martin, C, Martin, J, Martin, R, Mason, C, Massey, L, Mathias, J, Mathur, P, Maude, K, McArthur, D, McCain, S, McCluney, S, McFall, M, McIlroy, B, McKay, S, McKinley, N, McNair, A, McWhirter, D, Mekhail, P, Mellor, K, Merchant, J, Merker, L, Messenger, D, Miles, A, Mir, S, Mishra, A, Mistry, P, Miu, V, Moat, M, Mockford, K, Mohamed, E, Mohamed, I, Mondragon‐Pritchard, M, Moore, N, Moretti, L, Morris, H, Morrison, T, Morrison‐Jones, V, Moss, J, Moug, S, Mountford, D, Moynihan, R, Muhammad, K, Muldoon‐Smith, D, Mulholland, J, Mullan, M, Murgitroyd, E, Murugaiyan, K, Myers, A, Mykoniatis, I, Nana, G, Nash, T, Nassar, A, Newton, R, Ng, C, Ng, P, Nguyen, K, Nicholas, F, Noor, M, Nowers, J, Nugent, C, Nunn, A, Nunn, R, Obeid, N, O'Callaghan, J, O'Hara, R, Oke, O, Olivier, J, O'Neill, A, O'Neill, S, Osei‐Bordom, D, Osgood, L, Panagiotopoulos, S, Panchasara, B, Parks, R, Patel, H, Patel, P, Patel, R, Patel, S, Pawelec, K, Payne, C, Pearson, K, Perin, G, Peristerakis, I, Petronio, B, Phelan, L, Phillips, J, Pisaneschi, C, Pitt, J, Plunkett‐Reed, K, Ponchietti, L, Pouzi, A, Pouzi, M, Powell, A, Powell‐Chandler, A, Pranesh, N, Proctor, V, Pywell, S, Qureshi, A, Qureshi, N, Rahman, M, Rai, Z, Ramcharan, S, Rangarajan, K, Rashid, M, Reader, H, Rehman, A, Rehman, S, Rengifo, C, Richards, E, Richardson, N, Robinson, A, Robinson, D, Rossi, B, Rutherford, F, Sadien, I, Saghir, T, Sahnan, K, Salahia, G, Sarveswaran, J, Saunders, M, Scott, B, Scott, K, Seager, A, Seal, S, Sezen, E, Shaban, F, Shah, P, Shahmohammadi, M, Shamsiddinova, A, Shankar, S, Sharpe, A, Shatkar, V, Sheel, A, Shields, T, Shinkwin, M, Shurmer, J, Siddika, A, Siddiqui, S, Simson, R, Sinclair, P, Singh, B, Singh, S, Sivaraj, J, Skaife, P, Skelly, B, Skinner, A, Slim, N, Smart, C, Smart, N, Smith, F, Smith, I, Smith, R, Spence, G, Sreedhar, A, Steinke, J, Stevenson, L, Stewart‐Parker, E, Stott, M, Stubbs, B, Stylianides, N, Subramonia, S, Swinkin, M, Swinscoe, M, Symons, N, Tahir, W, Taj, T, Takacs, K, Tam, J, Tan, K, Tani, S, Tanner, N, Tao, D, Taylor, M, Thava, B, Thippeswamy, K, Thomas, C, Thompson, E, Thompson, R, Thompson‐Reil, C, Thorn, C, Tongo, F, Toth, G, Turnbull, A, Turnbull, J, Valero, C, Boxel, G, Varcada, M, Venn, M, Ventham, N, Venza, M, Vimalachandran, D, Virlos, I, Wade, T, Wafi, A, Waite, K, Walker, M, Walker, N, Walker, T, Walsh, U, Wardle, S, Warner, R, Watfah, J, Watson, N, Watt, J, Watts, J, Wayman, J, Weegenaar, C, West, H, West, M, Whitehurst, L, Whyler, M, Wiggans, M, Wijeyekoon, S, Williams, G, Williams, R, Williamson, A, Williamson, J, Wilson, J, Winter, A, Wolpert, L, Wong, J, Yeap, E, Yeong, T, Zaman, S, Zappa, B, and Zosimas, D

Subjects
Adult, Male, medicine.medical_specialty, National Audit of Small Bowel Obstruction Steering Group and National Audit of Small Bowel Obstruction Collaborators, Incisional hernia, lcsh:Surgery, 030230 surgery, Abdominal wall, 03 medical and health sciences, 0302 clinical medicine, Postoperative Complications, NASBO Collaborators, medicine, Humans, Hernia, Hospital Mortality, General, Emergency Treatment, Aged, Proportional Hazards Models, Aged, 80 and over, Groin, business.industry, Mortality rate, Hazard ratio, West Midlands Research Collaborative, General Medicine, Odds ratio, Original Articles, lcsh:RD1-811, Middle Aged, medicine.disease, Quality Improvement, United Kingdom, Surgery, Hernia, Abdominal, Bowel obstruction, medicine.anatomical_structure, Logistic Models, 030220 oncology & carcinogenesis, Original Article, Female, business, NASBO Steering Group, Intestinal Obstruction
Abstract

Background Abdominal wall hernia is a common surgical condition. Patients may present in an emergency with bowel obstruction, incarceration or strangulation. Small bowel obstruction (SBO) is a serious surgical condition associated with significant morbidity. The aim of this study was to describe current management and outcomes of patients with obstructed hernia in the UK as identified in the National Audit of Small Bowel Obstruction (NASBO). Methods NASBO collated data on adults treated for SBO at 131 UK hospitals between January and March 2017. Those with obstruction due to abdominal wall hernia were included in this study. Demographics, co‐morbidity, imaging, operative treatment, and in‐hospital outcomes were recorded. Modelling for factors associated with mortality and complications was undertaken using Cox proportional hazards and multivariable regression modelling. Results NASBO included 2341 patients, of whom 415 (17·7 per cent) had SBO due to hernia. Surgery was performed in 312 (75·2 per cent) of the 415 patients; small bowel resection was required in 198 (63·5 per cent) of these operations. Non‐operative management was reported in 35 (54 per cent) of 65 patients with a parastomal hernia and in 34 (32·1 per cent) of 106 patients with an incisional hernia. The in‐hospital mortality rate was 9·4 per cent (39 of 415), and was highest in patients with a groin hernia (11·1 per cent, 17 of 153). Complications were common, including lower respiratory tract infection in 16·3 per cent of patients with a groin hernia. Increased age was associated with an increased risk of death (hazard ratio 1·05, 95 per cent c.i. 1·01 to 1·10; P = 0·009) and complications (odds ratio 1·05, 95 per cent c.i. 1·02 to 1·09; P = 0·001). Conclusion NASBO has highlighted poor outcomes for patients with SBO due to hernia, highlighting the need for quality improvement initiatives in this group., This study shows that small bowel obstruction due to abdominal wall hernia is common, typically involves a co‐morbid group of patients and has poor outcomes, including high mortality rates. High mortality from this problem

Published
2020

34. 'Are We Really Not Going to Talk about the Black Girl?': The Intergroup Racial Attitudes of Senior, White, Sorority Women

Author

Tanner N. Terrell, Demetri L. Morgan, and Hilary B. Zimmerman

Subjects
Racial composition, White (horse), Higher education, business.industry, media_common.quotation_subject, 05 social sciences, 050301 education, Gender studies, Focus group, 0506 political science, Education, Gender Studies, Race (biology), 050602 political science & public administration, Girl, business, Psychology, 0503 education, media_common
Abstract

Despite the positive effects of cross-racial interactions for students, predominantly White sororities remain segregated. Utilizing focus group methods, this study investigates the racial attitudes...

Published
2018
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35. The In Silico Identification of Potential Members of the Ded1/DDX3 Subfamily of DEAD-Box RNA Helicases from the Protozoan Parasite Leishmania infantum and Their Analyses in Yeast

Author

Mokdadi, Molka, primary, Abdelkrim, Yosser Zina, additional, Banroques, Josette, additional, Huvelle, Emmeline, additional, Oualha, Rafeh, additional, Yeter-Alat, Hilal, additional, Guizani, Ikram, additional, Barhoumi, Mourad, additional, and Tanner, N. Kyle, additional

Published
2021
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44. 702. Characteristics of Infective Endocarditis (IE) and Predictors of 90-day Mortality Among People Who Do and Do Not Inject Drugs with IE in Seattle, Washington

Author

Corcorran, Maria A, primary, Stewart, Jenell C, additional, Lan, Kristine F, additional, Gupta, Ayushi, additional, Muggli, Tanner N, additional, Sharninghausen, Jody C, additional, Takasugi, Jordan, additional, Tietjen, Ty J, additional, Glick, Sara N, additional, Seshadri, Chetan, additional, Koomalsingh, Kevin, additional, Gibbons, Edward F, additional, Harrington, Robert, additional, Dhanireddy, Shireesha, additional, and Kim, H Nina, additional

Published
2020
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45. 702. Characteristics of Infective Endocarditis (IE) and Predictors of 90-day Mortality Among People Who Do and Do Not Inject Drugs with IE in Seattle, Washington

Author

Maria A Corcorran, Jenell C Stewart, Kristine F Lan, Ayushi Gupta, Tanner N Muggli, Jody C Sharninghausen, Jordan Takasugi, Ty J Tietjen, Sara N Glick, Chetan Seshadri, Kevin Koomalsingh, Edward F Gibbons, Robert Harrington, Shireesha Dhanireddy, and H Nina Kim

Subjects
medicine.medical_specialty, Univariate analysis, business.industry, medicine.disease, medicine.disease_cause, AcademicSubjects/MED00290, Infectious Diseases, Oncology, Bacterial endocarditis, Infective endocarditis, Clinical diagnosis, Internal medicine, Poster Abstracts, medicine, Coagulase, business, Staphylococcus
Abstract

Background People who inject drugs (PWID) are at high risk for IE and account for a growing proportion of IE cases in the United States. We describe key characteristics of IE and predictors of 90-day mortality among people who do and do not inject drug at two large academic medical centers. Methods We used a string-searching and pattern-matching algorithm within all discharge (DC) summaries to query the electronic medical record (EMR) for cases of IE among adults ≥18 years of age at two academic medical centers in Seattle, Washington from December 1, 2013 to July 31, 2019. All cases were chart reviewed by a member of the study team to confirm a clinical diagnosis of IE and verify housing and PWID status, the latter defined as any injection drug use in the 3 months prior to admission. Microbiology and valve involvement were extracted from DC summaries and chart-reviewed where needed. Deaths were obtained from Washington state death index, which links to our EMR. Descriptive statistics were used to compare PWID and non-PWID with IE, and Kaplan-Meier log rank tests and Cox proportional hazard models were used to assess for predictors of 90-day mortality. Results We identified 387 patients with IE, 44% (n=166) of whom were PWID. When compared to non-PWID, PWID were younger (median age 33 vs. 55 years, p< 0.001) and more likely to be female (48% vs. 31%, p=0.001), homeless (41% vs. 9%, p< 0.001), have coagulase-positive Staphylococcal IE (69% vs. 32%, p< 0.001), and have right sided IE (66% vs. 26%, p< 0.001). Seventeen percent (n=64) of patients died within 90 days of admission, including 14% (n=23) of PWID and 19% (n=41) of non-PWID, with no difference in 90-day mortality between these groups (log-rank p=0.3). In univariate analyses, having left sided IE was the only predictor of 90-day mortality (HR 4.79, 95% CI 2.18 – 10.5). Conclusion Despite PWID being significantly younger and having a much higher frequency of right sided IE, they had similar 90-day mortality to non-PWID in this contemporary, urban cohort of hospitalized IE patients. Table 1. Demographic Characteristics of People Who Do and Do Not Inject Drugs with Infective Endocarditis at Two Seattle Hospitals, 2014 – 2019 Disclosures All Authors: No reported disclosures

Published
2020
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46. National prospective cohort study of the burden of acute small bowel obstruction

Author

Lee, M. J., Sayers, A. E., Drake, T. M., Marriott, P. J., Anderson, I. D., Bach, S. P., Bradburn, M., Hind, D., Verjee, A., Fearnhead, N. S., Abercrombie, John, Acheson, Austin, Alderson, Derek, Anderson, Iain, Davies, Michael, Hamady, Zaed, Hollyman, Marianne, Hare, Sarah, Lee, Ellen, Northover, John, Lewis, Christopher, McFall, Malcolm, Murugananthan, Aravinth, Murray, David, Singh, Pritam, Tierney, Gillian, Walsh, Ciaran, Wild, Jonathan, Wilson, Timothy, Abbott, S, Abdulaal, Y, Afshar, S, Ah‐Chuen, J, Ahmed, T, Akhtar, M, Akram, F, Aldred, E, Ali, A, Aly, M, Amajuoyi, A, Amin, V, Anderson, D, Anderson, O, Andreou, A, Ansari, A, Appleton, S, Ardley, R, Arshad, F, Ashour, O, Asour, A, Athem, A, Athersmith, M, Ayoub, F, Azeem, H, Azhar, B, Badenoch, T, Baillie, C, Bandyopadhyay, D, Barker, J, Barker, S, Barkham, B, Baron, R, Barrie, J, Barry‐Yarrow, E, Bashir, G, Battersby, N, Bazoua, G, Behar, N, Bellam, S, Berger, C, Bhandari, S, Bhasin, S, Biggs, S, Bisset, C, Blake, L, Blencowe, N, Boam, T, Boddy, A, Boereboom, C, Bogdan, M, Bogle, R, Bohra, P, Boland, M, Bolkan, H, Borg, C, Boulton, R, Bouras, G, Boyer, M, Boyle, J, Branagan, G, Brewer, H, Briggs, C, Broadhurst, J, Brown, E, Brown, J, Brown, L, Brown, O, Burns, K, Butcher, K, Butler, M, Byrne, B, Campbell, L, Capper, C, Cartmell, M, Cash, T, Chan, S, Chandratreya, N, Chapman, J, Chapman, S, Charalabopoulos, A, Cheek, C, Chok, S, Choong, W, Chow, M, Chowdhury, J, Coe, P, Conaghan, P, Conn, G, Cook, N, Cook, T, Cooper, S, Cornish, J, Cotton, D, Cox, C, Coyne, P, Crook, R, Crozier, J, Cuffolo, G, Cunha, P, Curtis, N, Cutting, J, Da Costa, K, Silva, L, Das, B, Davenport, M, Davies, J, Davies, T, Day, A, Dayal, S, Dean, S, Demetriou, G, Dengu, F, Dennis, R, Dent, H, Dent, P, Deputy, M, Devoto, L, Di Benedetto, G, Dindyal, S, Donnelly, E, Doody, P, Douka, E, Downham, C, Dowson, H, Edent, H, Edgerton, K, Ekpete, N, El Farran, M, Elamin, O, Eljaafari, M, Elsaid, N, El‐Sharif, M, Evans, J, Evans, M, Ewe, R, Ewing, A, Exarchou, K, Fallaize, R, Faoury, M, Farag, S, Farinella, E, Faulkner, G, Ferguson, H, Fisher, O, Fletcher, J, Forouzanfar, A, Foster, A, Fox, R, Francis, N, Fretwell, V, Fung, D, Gammeri, E, Garnham, J, Geraghty, A, Gilbert, A, Gill, C, Gill, M, Gillespie, M, Giordano, P, Glasbey, J, Goh, M, Golder, A, Green, N, Gregoir, T, Grey, T, Groundwater, E, Grove, T, Growcott, S, Gunasekaran, S, Habib, H, Haddow, J, Halahakoon, V, Halkias, C, Hall, C, Hampson, A, Hancock, L, Hanna, T, Hannay, J, Harikrishnan, A, Harries, R, Harris, G, Hartley, J, Harvey, K, Hawkin, P, Hawkins, J, Healy, R, Heard, R, Heartshorne, R, Heller, S, Hendra, L, Herrod, P, Heywood, N, Hicks, G, Hobson, B, Holtham, S, Hope, C, Hopley, P, Hossain, T, Hossaini, S, Howse, F, Hubbard, T, Humphreys, A, Ikram, H, Ioannis, M, Iqbal, M, Iqbal, N, Jain, R, Jatania, J, Jenkinson, P, Jokhan, S, Jones, A, Jones, C, Jones, L, Joshi, H, Joshi, K, Joy, M, Jull, P, Kakaniaris, G, Kallam, R, Kane, E, Kang, P, Kanitkar, R, Kauser, S, Kazmi, F, Kedrzycki, M, Kelly, S, Kendall, J, Khan, M, Khan, T, King, G, Kisiel, A, Kitsis, C, Kolawole, I, Korambayil, S, Kosasih, S, Kosti, A, Kotb, A, Kouris, S, Kshatriya, K, Kumar, S, Lafaurie, G, Lal, R, Lau, A, Lazim, T, Lazzaro, A, Lee, K, Lefroy, R, Leinhardt, D, Lennon, H, Leong, K, Levy, B, Lim, E, Lim, J, Lindley, S, Liu, D, Lloyd, P, Locker, D, Lockwood, S, Lowe, C, Lund, J, Lunevicius, R, Lunt, A, Lutfi, S, Luther, A, Luwemba, S, Mahankali‐Rao, P, Mahroof, S, Mai, D, Majid, S, Malik, A, Malik, K, Mann, K, Mansour, S, Manu, N, Mapara, R, Martin, C, Martin, J, Martin, R, Mason, C, Massey, L, Mathias, J, Mathur, P, Maude, K, McArthur, D, McCain, S, McCluney, S, McIlroy, B, McKay, S, McKinley, N, McNair, A, McWhirter, D, Mekhail, P, Mellor, K, Merchant, J, Merker, L, Messenger, D, Miles, A, Mir, S, Mishra, A, Mistry, P, Miu, V, Moat, M, Mockford, K, Mohamed, E, Mohamed, I, Mondragon‐Pritchard, M, Moore, N, Moretti, L, Morris, H, Morrison, T, Morrison‐Jones, V, Moss, J, Moug, S, Mountford, D, Moynihan, R, Muhammad, K, Muldoon‐Smith, D, Mulholland, J, Mullan, M, Murgitroyd, E, Murugaiyan, K, Myers, A, Mykoniatis, I, Nana, G, Nash, T, Nassar, A, Newton, R, Ng, C, Ng, P, Nguyen, K, Nicholas, F, Noor, M, Nowers, J, Nugent, C, Nunn, A, Nunn, R, Obeid, N, O'Callaghan, J, O'Hara, R, Oke, O, Olivier, J, O'Neill, A, O'Neill, S, Osei‐Bordom, D, Osgood, L, Panagiotopoulos, S, Panchasara, B, Parks, R, Patel, H, Patel, P, Patel, R, Patel, S, Pawelec, K, Payne, C, Pearson, K, Perin, G, Peristerakis, I, Petronio, B, Phelan, L, Phillips, J, Pisaneschi, C, Pitt, J, Plunkett‐Reed, K, Ponchietti, L, Pouzi, A, Pouzi, M, Powell, A, Powell‐Chandler, A, Pranesh, N, Proctor, V, Pywell, S, Qureshi, A, Qureshi, N, Rahman, M, Rai, Z, Ramcharan, S, Rangarajan, K, Rashid, M, Reader, H, Rehman, A, Rehman, S, Rengifo, C, Richards, E, Richardson, N, Robinson, A, Robinson, D, Rossi, B, Rutherford, F, Sadien, I, Saghir, T, Sahnan, K, Salahia, G, Sarveswaran, J, Saunders, M, Scott, B, Scott, K, Seager, A, Seal, S, Sezen, E, Shaban, F, Shah, P, Shahmohammadi, M, Shamsiddinova, A, Shankar, S, Sharpe, A, Shatkar, V, Sheel, A, Shields, T, Shinkwin, M, Shurmer, J, Siddika, A, Siddiqui, S, Simson, R, Sinclair, P, Singh, B, Singh, S, Sivaraj, J, Skaife, P, Skelly, B, Skinner, A, Slim, N, Smart, C, Smart, N, Smith, F, Smith, I, Smith, R, Spence, G, Sreedhar, A, Steinke, J, Stevenson, L, Stewart‐Parker, E, Stott, M, Stubbs, B, Stylianides, N, Subramonia, S, Swinkin, M, Swinscoe, M, Symons, N, Tahir, W, Taj, T, Takacs, K, Tam, J, Tan, K, Tani, S, Tanner, N, Tao, D, Taylor, M, Thava, B, Thippeswamy, K, Thomas, C, Thompson, E, Thompson, R, Thompson‐Reil, C, Thorn, C, Tongo, F, Toth, G, Turnbull, A, Turnbull, J, Valero, C, Boxel, G, Varcada, M, Venn, M, Ventham, N, Venza, M, Vimalachandran, D, Virlos, I, Wade, T, Wafi, A, Waite, K, Walker, M, Walker, N, Walker, T, Walsh, U, Wardle, S, Warner, R, Watfah, J, Watson, N, Watt, J, Watts, J, Wayman, J, Weegenaar, C, West, H, West, M, Whitehurst, L, Whyler, M, Wiggans, M, Wijeyekoon, S, Williams, G, Williams, R, Williamson, A, Williamson, J, Wilson, J, Winter, A, Wolpert, L, Wong, J, Yeap, E, Yeong, T, Zaman, S, Zappa, B, Zosimas, D, Moug S Mondragon‐Pritchard, M, Rehan, S, and van Boxel, G

Abstract

Background: \ud Small bowel obstruction is a common surgical emergency, and is associated with high levels of morbidity and mortality across the world. The literature provides little information on the conservatively managed group. The aim of this study was to describe the burden of small bowel obstruction in the UK.\ud \ud Methods: \ud This prospective cohort study was conducted in 131 acute hospitals in the UK between January and April 2017, delivered by trainee research collaboratives. Adult patients with a diagnosis of mechanical small bowel obstruction were included. The primary outcome was in‐hospital mortality. Secondary outcomes included complications, unplanned intensive care admission and readmission within 30 days of discharge. Practice measures, including use of radiological investigations, water soluble contrast, operative and nutritional interventions, were collected.\ud \ud Results: \ud Of 2341 patients identified, 693 (29·6 per cent) underwent immediate surgery (within 24 h of admission), 500 (21·4 per cent) had delayed surgery after initial conservative management, and 1148 (49·0 per cent) were managed non‐operatively. The mortality rate was 6·6 per cent (6·4 per cent for non‐operative management, 6·8 per cent for immediate surgery, 6·8 per cent for delayed surgery; P = 0·911). The major complication rate was 14·4 per cent overall, affecting 19·0 per cent in the immediate surgery, 23·6 per cent in the delayed surgery and 7·7 per cent in the non‐operative management groups (P < 0·001). Cox regression found hernia or malignant aetiology and malnutrition to be associated with higher rates of death. Malignant aetiology, operative intervention, acute kidney injury and malnutrition were associated with increased risk of major complication.\ud \ud Conclusion: \ud Small bowel obstruction represents a significant healthcare burden. Patient‐level factors such as timing of surgery, acute kidney injury and nutritional status are factors that might be modified to improve outcomes.

Published
2019

50. Experimental study of π− π+ system at low invariant-masses

Author

Kernel, G., Korbar, D., Križan, P., Mikuž, M., Sever, F., Stanovnik, A., Starič, M., Zavrtanik, D., Michaelis, E. G., Tanner, N. W., van Eijk, C. W. E., Hollander, R. W., Lourens, W., Clark, S. A., Davies, J. D., Lowe, J., Playfer, S. M., Jovanovich, J. V., and Omicron Collaboration

Published
1991
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