14 results on '"Tania Hassanzadeh"'
Search Results
2. Gestational Exposure to Air Pollution Alters Cortical Volume, Microglial Morphology, and Microglia-Neuron Interactions in a Sex-Specific Manner
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Jessica L. Bolton, Steven Marinero, Tania Hassanzadeh, Divya Natesan, Dominic Le, Christine Belliveau, S. N. Mason, Richard L. Auten, and Staci D. Bilbo
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microglia ,air pollution ,microglia-neuron interactions ,cortical volume ,brain development ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Microglia are the resident immune cells of the brain, important for normal neural development in addition to host defense in response to inflammatory stimuli. Air pollution is one of the most pervasive and harmful environmental toxicants in the modern world, and several large scale epidemiological studies have recently linked prenatal air pollution exposure with an increased risk of neurodevelopmental disorders such as autism spectrum disorder (ASD). Diesel exhaust particles (DEP) are a primary toxic component of air pollution, and markedly activate microglia in vitro and in vivo in adult rodents. We have demonstrated that prenatal exposure to DEP in mice, i.e., to the pregnant dams throughout gestation, results in a persistent vulnerability to behavioral deficits in adult offspring, especially in males, which is intriguing given the greater incidence of ASD in males to females (∼4:1). Moreover, there is a striking upregulation of toll-like receptor (TLR) 4 gene expression within the brains of the same mice, and this expression is primarily in microglia. Here we explored the impact of gestational exposure to DEP or vehicle on microglial morphology in the developing brains of male and female mice. DEP exposure increased inflammatory cytokine protein and altered the morphology of microglia, consistent with activation or a delay in maturation, only within the embryonic brains of male mice; and these effects were dependent on TLR4. DEP exposure also increased cortical volume at embryonic day (E)18, which switched to decreased volume by post-natal day (P)30 in males, suggesting an impact on the developing neural stem cell niche. Consistent with this hypothesis, we found increased microglial-neuronal interactions in male offspring that received DEP compared to all other groups. Taken together, these data suggest a mechanism by which prenatal exposure to environmental toxins may affect microglial development and long-term function, and thereby contribute to the risk of neurodevelopmental disorders.
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- 2017
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3. Rare Complications in Chondrolaryngoplasty: Preparation for Safe Outcomes
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Tania Hassanzadeh and Jeffrey H. Spiegel
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Surgery - Abstract
Chondrolaryngoplasty ("tracheal shave") is a common procedure requested by transgender women as well as cisgender men and women. Management of intraoperative complications is crucial given the risk of damage to the vocal cords and loss of the airway in patients who are not intubated. We present two rare complications of chondrolaryngoplasty and their management.
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- 2022
4. An unusual complication after augmentation genioplasty: odontogenic infection requiring implant removal
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Tania Hassanzadeh and Arnold Lee
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Augmentation genioplasty is a common surgical procedure with extremely low infection rates. We present the case of a healthy middle-aged woman who experienced years of chronic infection after chin implantation due to a fractured mandibular canine root, which is exceedingly rare. Awareness of this potential complication will reduce patient morbidity.
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- 2021
5. Deep Space Neck Infections
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Jeremiah C. Tracy and Tania Hassanzadeh
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Anatomy ,NASA Deep Space Network ,Geology - Abstract
Deep neck space infections are a common reason for otolaryngology consultation. The anatomic spaces and their relationships are complex, and inappropriately treated infections may pose life-threatening consequences. It is critical for the practicing otolaryngologist to understand the boundaries and contents of the fascial spaces, microbiology of involved organisms, clinical workup, indications for medical and surgical management, and potential complications. This review contains 15 figures, 3 tables and 25 references. Key Words: Nodes of Rouviere, Danger space, Ludwig’s angina, Lemierre syndrome, Cavernous sinus thrombosis, Necrotizing fasciitis, Bezold abscess
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- 2021
6. Pharyngeal wall and soft palate motion after two common speech surgeries
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Tania, Hassanzadeh, Nicole C, Mastacouris, Kathleen C Y, Sie, Mark A, Vecchiotti, and Andrew R, Scott
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Adult ,Male ,Velopharyngeal Insufficiency ,Adolescent ,Reproducibility of Results ,Young Adult ,Treatment Outcome ,Otorhinolaryngology ,Child, Preschool ,Humans ,Pharynx ,Speech ,Female ,Palate, Soft ,Child ,Retrospective Studies - Abstract
To assess how pharyngeal wall and soft palate motion are affected after two common interventions for velopharyngeal insufficiency.A retrospective observational study was performed. A database of patients who had undergone Furlow palatoplasty or pharyngeal flap surgery between 2011 and 2019 and had video-archived preoperative and postoperative nasopharyngoscopy recordings was created. Recordings were deidentified and randomized, with 5 randomly-selected videos duplicated to determine intra-rater reliability. The videos were scored by 3 experienced raters using a modified Golding-Kushner scale. Pre- and postoperative scores were compared using paired t-test. Inter- and intra-rater reliability were estimated using intra-class correlation (ICC).There were 17 patients who met inclusion criteria. The mean age was 6.9 years (range 3-22 years, 59% male). In the Furlow palatoplasty group (n = 9), an increase in left soft palate motion was noted postoperatively (t(8) = 2.71, p = 0.02). In the pharyngeal flap group (n = 8), increases in lateral pharyngeal wall motion (left: t(7) = 3.58, p = 0.008, right: t(7) = 3.84, p = 0.006) and right soft palate motion (t(6) = 2.49, p = 0.04) were identified. Intra-rater reliability and inter-rater agreement were lower than prior studies utilizing the Golding Kushner scale.Our results provide objective evidence that Furlow palatoplasty and pharyngeal flap surgeries achieve velopharyngeal closure by increasing movement at different anatomical sites. Palatal and pharyngeal wall motion observed during preoperative nasopharyngoscopy may influence a surgeon's choice of intervention.
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- 2022
7. Fulminant and Diffuse Cerebral Toxoplasmosis as the First Manifestation of HIV Infection: A Case Presentation and Review of the Literature
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Alireza Khosravi, Salman Abbasi Fard, Tania Hassanzadeh, Afsaneh Mirshekar, Farhad Tabasi, Ali Khajeh, Safoora Masoumi, and Martin M. Mortazavi
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Male ,Pediatrics ,medicine.medical_specialty ,Opportunistic infection ,Fulminant ,Neurosurgery ,030204 cardiovascular system & hematology ,03 medical and health sciences ,Fatal Outcome ,0302 clinical medicine ,Midline shift ,Acquired immunodeficiency syndrome (AIDS) ,medicine ,Humans ,Child ,Intracranial pressure ,Coma ,AIDS-Related Opportunistic Infections ,business.industry ,Articles ,General Medicine ,medicine.disease ,Magnetic Resonance Imaging ,Toxoplasmosis ,Toxoplasmosis, Cerebral ,030220 oncology & carcinogenesis ,medicine.symptom ,business ,HIV infections - Abstract
Patient: Male, 9-year-old Final Diagnosis: Fulminant and diffuse cerebral toxoplasmosis Symptoms: Decreased level of consciousness • fever • generalized tonic-clonic seizures • hemiplegia Medication: — Clinical Procedure: Decompressive hemicraniectomy Specialty: Neurosurgery Objective: Unusual clinical course Background: One of the most common causes of central nervous system (CNS) opportunistic infections in immunocompromised patients is toxoplasmosis. It can cause focal or disseminated brain lesions leading to neurological deficit, coma, and death. Prompt management with optimal antibiotics is vital. However, the diagnosis of cerebral toxoplasmosis is challenging in infected individuals with human immunodeficiency virus (HIV). The possible diagnosis is based on clinical presentation, imaging, and specific serologic investigations. The diagnosis can be confirmed by histopathological examination and/or by finding nucleic material in the spinal cerebrospinal fluid (CSF) examination. Case Report: We present a review of the literature with a rare illustrative case of diffuse CNS toxoplasmosis as the first manifestation of HIV infection in a young patient. Brain MRI showed diffuse, ring-enhancing lesions, and significant midline shift. Decompressive hemicraniectomy for control of intracranial pressure and anti-infectious therapy were performed. Conclusions: This should raise awareness that cerebral toxoplasmosis can occur in pediatric patients with HIV infection, and, more importantly, as the first manifestation of AIDS. Although the prognosis is often poor, early diagnosis and immediate treatment of this life-threatening opportunistic infection can improve outcomes.
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- 2020
8. Cranial Osteomyelitis: A Comprehensive Review of Modern Therapies
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Salman Abbasi Fard, Syed A. Quadri, Hannah Grossman, Muhammad Adnan Khan, Tania Hassanzadeh, Kian M. Fahimdanesh, Martin M. Mortazavi, R. Shane Tubbs, M. Asif Taqi, and Sajid S. Suriya
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Skull Base ,medicine.medical_specialty ,business.industry ,Osteomyelitis ,Skull ,Surgical debridement ,Skull base osteomyelitis ,medicine.disease ,Surgery ,Diagnostic modalities ,Clinical communication ,03 medical and health sciences ,0302 clinical medicine ,Posterior skull base ,Temporal bone ,Humans ,Medicine ,Treatment Failure ,Neurology (clinical) ,030223 otorhinolaryngology ,business ,Medline database ,030217 neurology & neurosurgery - Abstract
Background Cranial osteomyelitis is a rare but potentially life-threatening condition that requires early diagnosis with prompt and appropriate management by neurosurgeons to prevent further central nervous system complications. Methods The literature in the Medline database was comprehensively reviewed with the keywords “cranial osteomyelitis,” “skull base osteomyelitis (SBO),” “central skull base osteomyelitis,” and “temporal bone osteomyelitis.” Items in the reference list of each article relevant to the objective of this study were reviewed. Results This review produced 183 articles: 13 book chapters, 24 case reports, 17 case series, 98 original articles, 30 review articles, and 1 meta-analysis. We classified cranial osteomyelitis as sinorhino-otogenic, including anterior, middle, and posterior skull base osteomyelitis; and non-sinorhino-otogenic, including iatrogenic, posttraumatic, hematologic, and osteomyelitis with other causes. Conclusions New diagnostic modalities, the introduction of broad-spectrum antibiotics, and recent advances in neurosurgical procedures have led to a decrease in the rate of treatment failure in cranial osteomyelitis. Early recognition of initial nonspecific symptoms is key to diagnosing and managing this treatable but life-threatening condition. Early identification of the causative pathogen, appropriate broad-spectrum antibiotic therapy over a period of 8–20 weeks, and aggressive surgical debridement are essential for managing cranial osteomyelitis. On the other hand, inadequate treatment is responsible for refractory cases and poses a great diagnostic challenge. A new classification dividing cranial osteomyelitis into sinorhino-otogenic versus nonsinorhino-otogenic groups could prove valuable for clinical communication and treatment.
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- 2018
9. Subarachnoid Trabeculae: A Comprehensive Review of Their Embryology, Histology, Morphology, and Surgical Significance
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Salman Abbasi Fard, Martin M. Mortazavi, Ian Armstrong, Muhammad Adnan Khan, Kian M. Fahimdanesh, Syed A. Quadri, Tania Hassanzadeh, Bryn A. Martin, Aaron Gustin, Farzad H. Adl, R. Shane Tubbs, M. Asif Taqi, and Sajid S. Suriya
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business.industry ,Histology ,Anatomy ,Neurovascular bundle ,medicine.disease ,Subarachnoid Space ,nervous system diseases ,030218 nuclear medicine & medical imaging ,Hydrocephalus ,03 medical and health sciences ,Dissection ,0302 clinical medicine ,Cerebrospinal fluid ,medicine.anatomical_structure ,Connective Tissue ,Arachnoid mater ,Embryology ,Humans ,Medicine ,Surgery ,Neurology (clinical) ,Subarachnoid space ,business ,030217 neurology & neurosurgery - Abstract
Introduction Brain is suspended in cerebrospinal fluid (CSF)-filled subarachnoid space by subarachnoid trabeculae (SAT), which are collagen-reinforced columns stretching between the arachnoid and pia maters. Much neuroanatomic research has been focused on the subarachnoid cisterns and arachnoid matter but reported data on the SAT are limited. This study provides a comprehensive review of subarachnoid trabeculae, including their embryology, histology, morphologic variations, and surgical significance. Methods A literature search was conducted with no date restrictions in PubMed, Medline, EMBASE, Wiley Online Library, Cochrane, and Research Gate. Terms for the search included but were not limited to subarachnoid trabeculae, subarachnoid trabecular membrane, arachnoid mater, subarachnoid trabeculae embryology, subarachnoid trabeculae histology, and morphology. Articles with a high likelihood of bias, any study published in nonpopular journals (not indexed in PubMed or MEDLINE), and studies with conflicting data were excluded. Results A total of 1113 articles were retrieved. Of these, 110 articles including 19 book chapters, 58 original articles, 31 review articles, and 2 case reports met our inclusion criteria. Conclusions SAT provide mechanical support to neurovascular structures through cell-to-cell interconnections and specific junctions between the pia and arachnoid maters. They vary widely in appearance and configuration among different parts of the brain. The complex network of SAT is inhomogeneous and mainly located in the vicinity of blood vessels. Microsurgical procedures should be performed with great care, and sharp rather than blunt trabecular dissection is recommended because of the close relationship to neurovascular structures. The significance of SAT for cerebrospinal fluid flow and hydrocephalus is to be determined.
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- 2018
10. The role of same-sex mentorship and organizational support in encouraging women to pursue surgery
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Simin G. Roward, Erynne A Faucett, Tania Hassanzadeh, Hilary C. McCrary, Leigh Neumayer, and Tijana Milinic
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Adult ,Male ,Students, Medical ,Medical psychology ,education ,MEDLINE ,Likert scale ,Physicians, Women ,03 medical and health sciences ,Social support ,0302 clinical medicine ,Mentorship ,Nursing ,Surveys and Questionnaires ,Humans ,Medicine ,030212 general & internal medicine ,Single institution ,Career Choice ,business.industry ,Mentors ,Arizona ,Social Support ,General Medicine ,General Surgery ,030220 oncology & carcinogenesis ,Same sex ,Female ,Surgery ,business ,Career choice - Abstract
While women represent approximately half of all medical students, only 38% of general surgery residents are women. The objective of this study is to explore how access to mentors and organizational support affects career choices.In June of 2016, a survey was sent to medical students at a single institution (n = 472). Questions utilized a 5-point Likert scale. A two-sample t-test was used to evaluate data.A total of 160 students participated in the survey. Among MS1/MS2 students, women were more likely to rank same-sex role models as a positive influence (mean 3.1 vs. 2.4; p 0.05). Similar results were seen among MS3/MS4 students (mean 3.6 vs. 2.5; p 0.05). More women ranked the presence of organizations that support women in surgery as being important (mean 4.6 vs. 4.1; p 0.05).Exposure to same-sex mentors was highly rated among female participants. These findings encourage the creation of national mentorship programs. Early involvement in organizations can positively influence career choice. Addressing gaps in mentorship opportunities and widening accessibility to national organizations are important in reducing barriers.
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- 2017
11. Neurological Aspects of Spinal Cord Tumors
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Tania Hassanzadeh, Andrei V. Alexandrov, Sushma Bellamkonda, Sajid S. Suriya, Martin M. Mortazavi, and Farzad H. Adl
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medicine.medical_specialty ,Elevated level ,medicine.diagnostic_test ,business.industry ,Neoplastic disease ,Physical examination ,Disease ,Spinal cord ,Diagnostic modalities ,medicine.anatomical_structure ,Slow progression ,medicine ,Radiology ,Medical diagnosis ,business - Abstract
This chapter discusses neurological aspects of spinal cord tumors, including clinical symptoms and syndromes, examination techniques, and diagnostic modalities. An emphasis is placed on earlier disease diagnosis as spinal cord tumors are known for delayed diagnoses. Usual causes for this delay consist of slow progression, an incomplete physical examination or misinterpretation of exam findings, late pursuit of imaging, imaging at the incorrect level, or nonspecific symptoms—such as back pain—that is misconstrued as the more prevalent degenerative spine disease. Every physician should maintain an elevated level of suspicion of spinal cord tumors and take the appropriate steps toward diagnosis, until neoplastic disease is definitively ruled out.
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- 2019
12. Falxuplication, a Novel Method for Wrap-Clipping a Fusiform Aneurysm: Technical Note
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Kianoush Khalili, Salman Abbasi Fard, R. Shane Tubbs, M. Asif Taqi, Sajid S. Suriya, Martin M. Mortazavi, and Tania Hassanzadeh
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medicine.medical_specialty ,Subarachnoid hemorrhage ,Computed Tomography Angiography ,medicine.medical_treatment ,Fusiform Aneurysm ,Neurosurgical Procedures ,03 medical and health sciences ,0302 clinical medicine ,Aneurysm ,medicine.artery ,medicine ,Anterior cerebral artery ,Humans ,cardiovascular diseases ,030212 general & internal medicine ,medicine.diagnostic_test ,business.industry ,Angiography, Digital Subtraction ,Intracranial Aneurysm ,Anatomy ,Clipping (medicine) ,Pericallosal Artery ,Subarachnoid Hemorrhage ,medicine.disease ,Surgical Instruments ,Surgery ,Cerebral Angiography ,Falx cerebri ,Spinal Cord ,cardiovascular system ,Female ,Neurology (clinical) ,business ,Tomography, X-Ray Computed ,030217 neurology & neurosurgery ,Cerebral angiography - Abstract
Background Various techniques have been used for wrap-clipping a ruptured, fusiform intracranial aneurysm; however, there is no available literature on use of the falx cerebri for wrap-clipping. We present a review of the literature, with an illustrative case, of a ruptured fusiform pericallosal artery aneurysm firmly attached to the lower edge of the falx cerebri and not amenable to endovascular intervention. Methods Although the firm attachment between the inferior falx and the fusiform aneurysm was maintained, a section of the lower thinner part of the falx cerebri firmly attached to the aneurysm was dissected and wrapped around the fusiform aneurysm, and then stabilized with a fenestrated clip. We chose a segment slightly longer than the length of the fusiform aneurysm to avoid pre– and post–wrap-clipping stenosis. Results Postprocedure, except for a small area of numbness on the left distal anterolateral left leg, the patient was neurologically intact and remained neurologically intact at a 12-month follow-up. Conclusions An inferior thin segment of the falx cerebri can be used for wrap-clipping of ruptured fusiform anterior cerebral artery aneurysms. Furthermore, the inferior falx can be wrapped around the attached fusiform anterior cerebral artery aneurysm without compromising flow, offering a safe solution in these unusually complex cases.
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- 2017
13. A second look at the utility of serial routine repeat computed tomographic scans in patients with traumatic brain injury
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Ansab A. Haider, Andrew Tang, Tania Hassanzadeh, Peter Rhee, Narong Kulvatunyou, Terence O'Keeffe, Tahereh Orouji, Rifat Latifi, Bellal Joseph, and Adil Farman
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Male ,medicine.medical_specialty ,Traumatic brain injury ,Poison control ,Computed tomographic ,Trauma Centers ,Medicine ,Humans ,In patient ,Glasgow Coma Scale ,Prospective Studies ,Neurologic decline ,Prospective cohort study ,business.industry ,Trauma center ,General Medicine ,Middle Aged ,medicine.disease ,Surgery ,Brain Injuries ,Disease Progression ,Female ,business ,Tomography, X-Ray Computed - Abstract
Background The practice of a routine repeat head computed tomographic scans in patients with traumatic brain injury (TBI) is under question. The aim of our study was to evaluate the utility of a more than 1 repeat head computed tomography (M1CT) scans in patients with TBI. Methods We performed a 3-year analysis of a prospectively collected database of all TBI patients presenting to our level I trauma center. Patients who received M1CT scans were included. Findings and reason (without neurologic decline vs after neurologic decline) for M1CT were recorded. Primary outcome measure was neurosurgical intervention. Results A total of 296 patients that underwent M1CT were included. Of those, 291 patients (98.6%) had M1CT without a neurologic decline, and neurosurgical intervention was performed in 1 patient (.3%) who was inexaminable (Glasgow coma scale score = 6). The remaining (n = 5) had M1CT due to a neurologic decline; 4 patients (80%) of the 5 had worsening of ICH; and neurosurgical intervention was performed in 3 (75%) of the 4 patients. Conclusions The practice of multiple repeat head computed tomographic scans should be limited to inexaminable patients or patients with neurological deterioration.
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- 2015
14. Iron Sucrose Impairs Phagocytic Function and Promotes Apoptosis in Polymorphonuclear Leukocytes
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Tania Hassanzadeh, Yuichi Masuda, Mateen Saffarian, Hirohito Ichii, Nosratola D. Vaziri, and Sastry Gollapudi
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Adult ,Male ,Staphylococcus aureus ,Time Factors ,Neutrophils ,Anemia ,Population ,Carbohydrates ,Apoptosis ,Inflammation ,Iron sucrose ,Ferric Compounds ,Article ,Microbiology ,End stage renal disease ,Glucaric Acid ,Phagocytosis ,In vivo ,Escherichia coli ,medicine ,Medicine and Health Sciences ,Humans ,education ,Ferric Oxide, Saccharated ,education.field_of_study ,business.industry ,Carbohydrate ,Flow Cytometry ,medicine.disease ,Nephrology ,Hematinics ,Kidney Failure, Chronic ,Female ,medicine.symptom ,business ,medicine.drug - Abstract
Background: With the recent implementation of bundling reimbursement policy, the use of intravenous (IV) iron preparations for the management of anemia in the end-stage renal disease (ESRD) population has dramatically increased. Iron overload increases the risk of infections in individuals with or without kidney disease. IV iron administration in ESRD patients impairs bacteriocidal capacity of polymorphonuclear leukocytes (PMNs) against Escherichia coli. These preparations consist of an elemental iron core and a carbohydrate shell. In addition to the iron core, the carbohydrate shell may affect PMNs. We therefore examined the effect of iron sucrose, a commonly used preparation, on phagocytic capacity of PMNs from a group of normal individuals against Gram-positive (Staphylococcus aureus) and Gram-negative (E. coli) bacteria. Methods: Iron sucrose was added to heparinized blood samples at pharmacologically-relevant concentrations and incubated for 4 and 24 h at 37°C to simulate in vivo condition. Blood samples mixed with equal volume of saline solution served as controls. To isolate the effects of the carbohydrate shell, blood samples were co-treated with the iron chelator, desferrioxamine. Results: Iron sucrose caused significant PMN apoptosis and dose-dependent suppression of phagocytic function against both Gram-positive and Gram-negative bacteria. These abnormalities were prevented by desferrioxamine which precluded contribution of the carbohydrate shell to the PMN dysfunction. Conclusions: At pharmacologically-relevant concentrations, iron sucrose promotes apoptosis and inhibits phagocytic activities of PMNs. The deleterious effect of iron sucrose is mediated by its elemental iron core, not its carbohydrate shell, and as such may be shared by other IV iron preparations.
- Published
- 2012
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