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Your search keyword '"Tang, Zhong-Hua"' showing total 282 results
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282 results on '"Tang, Zhong-Hua"'

13. Blocking ATM-dependent NF-κB pathway overcomes niche protection and improves chemotherapy response in acute lymphoblastic leukemia

Author

Chen, Ya-Li, Tang, Chao, Zhang, Meng-Yi, Huang, Wen-Li, Xu, Yan, Sun, Hui-Yin, Yang, Fan, Song, Li-Li, Wang, He, Mu, Li-Li, Li, Ming-Hao, Zheng, Wei-Wei, Miao, Yan, Ding, Li-Xia, Li, Ben-Shang, Shen, Shu-Hong, Liu, Sheng-Li, Li, Hui, Zhu, Zhong-Qun, Chen, Hui-Wen, Tang, Zhong-Hua, Chen, Jing, Hong, Deng-Li, Chen, Hong-Zhuan, Duan, Cai-Wen, and Zhou, Bin-Bing S.

Published
2019
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19. MS/MS molecular networking‐guided in‐depth profiling of triterpenoid saponins from the fruit ofEleutherococcus senticosusand their neuroprotectivity evaluation

Author

Zhou, Yu, primary, Ren, Ying‐Shan, additional, Li, Xi‐Tao, additional, Cai, Meng‐Ting, additional, Li, Hui‐Lin, additional, Ding, Wen‐Luan, additional, Wu, Yu‐Hang, additional, Guo, Hai‐Biao, additional, Tang, Zhong‐Hua, additional, Sun, Fei, additional, Chen, A‐Li, additional, Piao, Xiu‐Hong, additional, Wang, Shu‐Mei, additional, and Ge, Yue‐Wei, additional

Published
2022
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27. MS/MS molecular networking‐guided in‐depth profiling of triterpenoid saponins from the fruit of Eleutherococcus senticosus and their neuroprotectivity evaluation.

Author

Zhou, Yu, Ren, Ying‐Shan, Li, Xi‐Tao, Cai, Meng‐Ting, Li, Hui‐Lin, Ding, Wen‐Luan, Wu, Yu‐Hang, Guo, Hai‐Biao, Tang, Zhong‐Hua, Sun, Fei, Chen, A‐Li, Piao, Xiu‐Hong, Wang, Shu‐Mei, and Ge, Yue‐Wei

Abstract

Introduction: Eleutherococcus senticosus fruit (ESF) is a natural health supplement resource that has been extensively applied as a tonic for the nervous system. The structures and neural bioactivities of triterpenoid saponins (TS), which are the major constituents of ESF, have not been comprehensively analyzed thus far. Objective: We conducted a complete in‐depth MS/MS molecular networking (MN)‐based targeted analysis of TS from the crude extract of ESF and investigated its neuroprotective value. Methods: An MS/MS MN‐guided strategy was used to rapidly present a series of precursor ions (PIs) of TS in a compound cluster as TS‐targeted information used in the discovery and characterization of TS. In addition, a prepared TS‐rich fraction of ESF was assayed for its restraining effects on β‐amyloid‐induced inhibition of neurite outgrowth. Results: A total of 87 TS were discovered using a PI tracking strategy, 28 of which were characterized as potentially undescribed structures according to their high‐resolution MS values. Furthermore, the TS‐rich fraction can significantly reduce β‐amyloid‐induced damage to neural networks by promoting the outgrowth of neurites and axons. Conclusion: Our findings reveal the richness of TS in ESF and will accelerate their application in the treatment of neurodegenerative diseases. Eleutherococcus senticosus fruit (ESF) is a natural health supplement resource that has been extensively applied as a tonic for the nervous system. In this paper, a comprehensive LC‐MS analysis of triterpene saponins (TS) from ESF was performed using an MS/MS molecular networking strategy, and 87 TS were finally tracked, of which 28 TS were potential new saponins. In addition, the TS‐rich fraction of ESF was prepared and assayed for their restraining effect on the β‐amyloid‐induced destruction of neurite outgrowth. [ABSTRACT FROM AUTHOR]

Published
2023
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36. Clinicopathological characteristics and treatment of young women with breast cancer in China: a nationwide multicenter 10-year retrospective study

Author

Zhang, Wei, primary, Zhang, Bai-Lin, additional, He, Jian-Jun, additional, Fan, Jin-Hu, additional, Li, Jing, additional, Zhang, Bin, additional, Yang, Hong-Jian, additional, Xie, Xiao-Ming, additional, Tang, Zhong-Hua, additional, Li, Hui, additional, Li, Jia-Yuan, additional, Wang, Shu-Lian, additional, Qiao, You-Lin, additional, Huang, Rong, additional, and Zhang, Pin, additional

Published
2021
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40. Bromodomains and Extra-Terminal (BET) Inhibitor JQ1 Suppresses Proliferation of Acute Lymphocytic Leukemia by Inhibiting c-Myc-Mediated Glycolysis

Author

Zhang, Meng-Yi, primary, Liu, Sheng-Li, additional, Huang, Wen-Li, additional, Tang, Da-Bin, additional, Zheng, Wei-Wei, additional, Zhou, Neng, additional, Zhou, Hang, additional, Abudureheman, Tuersunayi, additional, Tang, Zhong-Hua, additional, Zhou, Bin-Bing S., additional, and Duan, Cai-Wen, additional

Published
2020
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45. Breast cancer stage at diagnosis and area-based socioeconomic status: a multicenter 10-year retrospective clinical epidemiological study in China

Author

Wang Qiong, Li Jing, Zheng Shan, Li Jia-Yuan, Pang Yi, Huang Rong, Zhang Bao-Ning, Zhang Bin, Yang Hong-Jian, Xie Xiao-Ming, Tang Zhong-Hua, Li Hui, He Jian-Jun, Fan Jin-Hu, and Qiao You-Lin

Subjects
Breast cancer, Stage at diagnosis, Area-based socioeconomic status, Nation-wide, Multi-center, Retrospective study, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Although socioeconomic status (SES) has been focused on as a key determinant of cancer stage at diagosis in western countries, there has been no systemic study on the relationship of SES and breast cancer stage at diagnosis in China. Methods The medical charts of 4,211 eligible breast cancer patients from 7 areas across China who were diagnosed between 1999 and 2008 were reviewed. Four area-based socioeconomic indicators were used to calculate area-based SES by cluster analysis. The associations between area-based SES and stage at diagnosis were analyzed by trend chi-square tests. Binary logistic regression was performed to estimate odds ratios for individual demographic characteristics' effects on cancer stages, stratified by area-based SES. Results The individual demographic and pathologic characteristics of breast cancer cases were significantly different among the seven areas studied. More breast cancer cases in low SES areas (25.5%) were diagnosed later (stages III & IV) than those in high (20.4%) or highest (14.8%) SES areas (χ2 for trend = 80.79, P < 0.001). When area-based SES is controlled for, in high SES areas, cases with less education were more likely to be diagnosed at later stages compared with more educated cases. In low SES areas, working women appeared to be diagnosed at earlier breast cancer stages than were homemakers (OR: 0.18-0.26). Conclusions In China, women in low SES areas are more likely to be diagnosed at later breast cancer stages than those in high SES areas.

Published
2012
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48. Additional file 1: of Chemotherapy-induced niche perturbs hematopoietic reconstitution in B-cell acute lymphoblastic leukemia

Author

Tang, Chao, Li, Ming-Hao, Chen, Ya-Li, Sun, Hui-Ying, Liu, Sheng-Li, Zheng, Wei-Wei, Meng-Yi Zhang, Li, Hui, Fu, Wei, Zhang, Wen-Jun, Liang, Ai-Bin, Tang, Zhong-Hua, Deng-Li Hong, Bin-Bing Zhou, and Cai-Wen Duan

Subjects
hemic and immune systems, humanities, health care economics and organizations
Abstract

Figure S1. Chemotherapy-induced niche contributes to the increase of ROS and apoptosis in HSCs. (a) HSCs apoptosis in Ctrl+DNR and B-ALL+DNR was analyzed by flow cytometry. (b) Statistical summary of apoptotic cell ratio of HSCs in (a). n = 4–8 mice per group. (c) The intracellular ROS level of HSCs in Ctrl+DNR and B-ALL+DNR was detected by H2-DCFDA staining. (d) Statistical summary of ROS level distribution in (c). n = 4–8 mice per group. (PPTX 111 kb)

Published
2018
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