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41 results on '"Tang, Xiaotong"'

17. A novel regulatory mechanism network mediated by lncRNA TUG1 that induces the impairment of spiral artery remodeling in preeclampsia

Author

Xu, Yetao, primary, Wu, Dan, additional, Hui, Bingqing, additional, Shu, Lijun, additional, Tang, Xiaotong, additional, Wang, Cong, additional, Xie, Jiaheng, additional, Yin, Yin, additional, Sagnelli, Matthew, additional, Yang, Nana, additional, Jiang, Ziyan, additional, Zhang, Yuanyuan, additional, and Sun, Lizhou, additional

Published
2022
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28. ZhiShiXiaoPi tang inhibits autophagy induced by corticosterone and functional dyspepsia through blockade of the mTOR pathway

Author

Zhao Yuanhui, Yu Yanhui, Qingxia Huang, Qu Xiaofeng, Xu Jian, Tang Xiaotong, Gong Haiquan, Tian Linlin, Xu Yun, Gao Song, and Wu Ping

Subjects
Male, Apoptosis, Pharmacology, Neuroprotection, PC12 Cells, Rats, Sprague-Dawley, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Corticosterone, In vivo, Drug Discovery, Autophagy, Animals, Viability assay, Dyspepsia, Medicine, Chinese Traditional, PI3K/AKT/mTOR pathway, 030304 developmental biology, Membrane Potential, Mitochondrial, Neurons, 0303 health sciences, TOR Serine-Threonine Kinases, In vitro, Rats, Neuroprotective Agents, chemistry, Gastric Emptying, 030220 oncology & carcinogenesis, Gastrointestinal Motility
Abstract

Ethnopharmacological relevance ZhiShiXiaoPi Tang (ZSXPT) is a Chinese traditional medicine formula that contains 10 Chinese traditional medicine substances. It has been widely used to treat patients with functional dyspepsia (FD). However, the protective effect of ZSXPT and its molecular mechanisms in FD still remain elusive. Aim of the study To investigate the protective effect of ZSXPT on autophagy induced by Corticosterone (Cort) in PC12 cells which have typical neuron characteristics and have been widely used as a model system for depression studies and FD rats, and explore its underlying mechanisms. Materials and methods In this study, high-performance liquid chromatography fingerprint analysis was performed to characterize the chemical composition of ZSXPT. Depression-induced autophagy, ROS generation, and changes in mitochondrial membrane potential (MMP) were investigated in Cort-induced PC12 cells and in FD rats to evaluate the protective effects of ZSXPT. Results Our results show that ZSXPT treatment protects neurons against Cort-induced damage and apoptosis by increasing cell viability and reducing the release of lactate dehydrogenase. ZSXPT decreased Cort-induced ROS generation, increased MMP, and accelerated autophagy through the blockade of the mammalian target of rapamycin (mTOR) pathway. Moreover, we observed similar findings when we studied ZSXPT in a rat model of FD. Conclusions Our in vitro and in vivo results indicate that the neuroprotective effect of ZSXPT against autophagy-induced damage and apoptosis occurs mainly by blocking the mTOR pathway in Cort-induced PC12 cells and in FD rats. Taken together, these data provide reliable experimental evidence and explain the molecular mechanism by which ZSXPT ameliorates FD.

Published
2018

40. IGF2BP2 enhances LincRNA01116 stability via m 6 A: A potential biomarker and therapeutic target for patients with pre-eclampsia.

Author

Zhang T, Tang X, Zhu Y, Wang C, Jiang Z, Yang N, Wang T, Shu L, Xu Y, and Sun L

Subjects
Humans, Female, Pregnancy, Placenta metabolism, Trophoblasts metabolism, Biomarkers metabolism, Cell Proliferation genetics, Cell Movement genetics, RNA-Binding Proteins metabolism, MicroRNAs genetics, Pre-Eclampsia genetics, RNA, Long Noncoding genetics
Abstract

Pre-eclampsia (PE) is a serious complication in pregnant women characterized by failure of placental remodeling and is one of the primary causes of changes in the placental structure and function. The aberrant expression of long noncoding RNA is associated with the occurrence and progression of PE. This study found that linc01116 expression was significantly downregulated in PE patients and was related to poor uterine spiral artery remodeling. Knockdown of linc01116 remarkably decreased the angiogenesis of trophoblast cells in vitro and in vivo. Mechanistically, IGF2BP2 regulated linc01116 RNA stability via m 6 A methylation. Bioinformatics and other experiments further revealed that linc01116 upregulates AAMP expression by adsorbing miR-210-3p in trophoblast cells. In conclusion, this study revealed the critical role of linc01116 in regulating trophoblast angiogenesis. Furthermore, the study provides new clues for detecting placental pathology in PE., (© 2022 Wiley Periodicals LLC.)

Published
2023
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41. Maternal and neonatal outcomes of repeated antepartum bleeding in 493 placenta previa cases: a retrospective study.

Author

Huang S, Zuo Q, Wang T, Tang X, Ge Z, Lu H, Zhou X, and Jiang Z

Subjects
Infant, Newborn, Female, Humans, Pregnancy, Retrospective Studies, Uterine Hemorrhage etiology, Uterine Hemorrhage complications, Pregnancy Outcome epidemiology, Cesarean Section adverse effects, Risk Factors, Placenta Previa epidemiology
Abstract

Objective: To explore the effect of antepartum bleeding caused by PP on pregnancy outcomes., Study Design: We retrospectively analyzed 493 pregnant women complicated with PP. Patients were divided into antepartum repeated bleeding and non-bleeding groups. Maternal characteristics and pregnancy outcomes were compared., Results: The risk of antepartum hemorrhage was 2.038 times higher when gravidity was 5 (95% CI 1.104-3.760, p  = .023). Pregnant women with a history of more than three intrauterine procedures had a 1.968 times higher risk of antepartum hemorrhage (95% CI 1.135-3,412, p  = .016) compared to pregnant women without any intrauterine procedures. The risk of antepartum bleeding was found to be decreasing with the pregnancy advancing; When the placenta edge was noted to be over cervical os, the risk of antepartum bleeding was 4.385-fold than the low-lying plcaenta cases (95%CI2.454-8.372, p  = .000). In the respect of maternal outcomes, the repeated bleeding group, the risk of emergency surgery was 7.213 times higher than elective surgery (95% CI 4.402-11.817, p  = .000). As for the neonatal outcomes, the risk of asphyxia was 2.970 times and the risk of neonatal intensive care unit (NICU) admission was 2.542-fold higher in repeated bleeding group compared to non-bleeding group, respectively., Conclusions: Obstetricians should be aware of the increased risk of antepartum bleeding especially for ≤34 weeks and placenta edge over cervical os PP patients, they have a higher risk of antepartum bleeding. These women have higher possibility of emergency C-section and need preterm newborn resuscitation.

Published
2022
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