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1. Performance assessment of the HERD calorimeter with a photo-diode read-out system for high-energy electron beams

Author: Adriani, O., Ambrosi, G., Antonelli, M., Bai, Y., Bai, X., Bao, T., Barbanera, M., Berti, E., Betti, P., Bigongiari, G., Bongi, M., Bonvicini, V., Bottai, S., Cagnoli, I., Cao, W., Casaus, J., Cerasole, D., Chen, Z., Cui, X., D'Alessandro, R., Di Venere, L., Diaz, C., Dong, Y., Detti, S., Duranti, M., Gargano, F., Gao, J., Guo, S., Giovacchini, F., Finetti, N., Formato, V., Jiang, Y., Liang, X., Li, R., Liao, C., Liu, X., Lyu, L., Marin, J., Martinez, G., Mori, N., Oliva, A., Pacini, L., Papini, P., Pillera, R., Pizzolotto, C., Quan, Z., Qin, J. J., Silveri, L., Silvestre, G., Shi, D., Serini, D., Starodubtsev, O., Tang, X., Tiberio, A., Vannuccini, E., Velasco, M., Wang, B., Wang, J., Wang, R., Wang, Z., Xu, M., Yang, X., Zampa, G., Zampa, N., Zhang, S., and Zheng, J.
Subjects: Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract: The measurement of cosmic rays at energies exceeding 100 TeV per nucleon is crucial for enhancing the understanding of high-energy particle propagation and acceleration models in the Galaxy. HERD is a space-borne calorimetric experiment that aims to extend the current direct measurements of cosmic rays to unexplored energies. The payload is scheduled to be installed on the Chinese Space Station in 2027. The primary peculiarity of the instrument is its capability to measure particles coming from all directions, with the main detector being a deep, homogeneous, 3D calorimeter. The active elements are read out using two independent systems: one based on wavelength shifter fibers coupled to CMOS cameras, and the other based on photo-diodes read-out with custom front-end electronics. A large calorimeter prototype was tested in 2023 during an extensive beam test campaign at CERN. In this paper, the performance of the calorimeter for high-energy electron beams, as obtained from the photo-diode system data, is presented. The prototype demonstrated excellent performance, e.g., an energy resolution better than 1% for electrons at 250 GeV. A comparison between beam test data and Monte Carlo simulation data is also presented.
Published: 2024

2. CHIMPS2: $^{13}$CO $J = 3 \to 2$ emission in the Central Molecular Zone

Author: King, S. M., Moore, T. J. T., Henshaw, J. D., Longmore, S. N., Eden, D. J., Rigby, A. J., Rosolowsky, E., Tahani, K., Su, Y., Yiping, A., Tang, X., Ragan, S., Liu, T., Kuan, Y. -J., and Rani, R.
Subjects: Astrophysics - Astrophysics of Galaxies
Abstract: We present the initial data for the ($J = 3 \to 2$) transition of $^{13}$CO obtained from the Central Molecular Zone (CMZ) of the Milky Way as part of the CO Heterodyne Inner Milky Way Plane Survey 2 (CHIMPS2). Covering $359^\circ \leq l \leq 1^\circ$ and $|b| \leq 0.5^\circ$ with an angular resolution of 19 arcsec, velocity resolution of 1 km s$^{-1}$, and rms $T_A^* = 0.59$ K at these resolutions, our observations unveil the complex structure of the CMZ molecular gas in improved detail. Complemented by the $^{12}$CO CHIMPS2 data, we estimate a median optical depth of $\tau_{13} = 0.087$. The preliminary analysis yields a median $^{13}$CO column density range equal to $N(^{13}\text{CO})= 2$--$5 \times 10^{18}$ cm$^{-2}$, median H$_2$ column density equal to $N(\text{H}_2)= 4 \times 10^{22}$ cm$^{-2}$ to $1 \times 10^{23}$ cm$^{-2}$. We derive $N(\text{H}_2)$-based total mass estimates of $M(\text{H}_2)= 2$--$6 \times 10^7\, M_{\odot}$, in agreement with previous studies. We analyze the relationship between the integrated intensity of $^{13}$CO and the surface density of compact sources identified by Herschel Hi-GAL, and find that younger Hi-GAL sources detected at 500 $\mu$m but not at 70 $\mu$m follow the dense gas of the CMZ more closely than those that are bright at 70 $\mu$m. The latter, actively star-forming sources, appear to be more associated with material in the foreground spiral arms., Comment: 13 pages, 9 figures
Published: 2024
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3. Automatic modulation classification for MIMO system based on the mutual information feature extraction

Author: Ussipov, N., Akhtanov, S., Zhanabaev, Z., Turlykozhayeva, D., Karibayev, B., Namazbayev, T., Almen, D., Akhmetali, A., and Tang, X.
Subjects: Electrical Engineering and Systems Science - Signal Processing
Abstract: Automatic Modulation Classification (AMC) is an essential technology that is widely applied into various communications scenarios. In recent years, many Machine Learning and Deep-Learning methods have been introduced into AMC, and a lot of them apply different approaches to eliminate interference in complex Multiple-Input and Multiple-Output (MIMO) signals and improve classification performance. However, in practical communication systems, the perfect elimination of MIMO signal interference is impossible, and therefore classification performance suffers. In this paper, we propose a new AMC algorithm for MIMO system based on mutual information (MI) features extraction, which does not require a large amount of training data and the elimination of MIMO signal interference. In this approach, features based on mutual information are extracted using In-Phase and Quadrature (IQ) constellation diagrams of MIMO signals, which have not been explored previously. Our method can be effective since mutual information considers the interdependencies among variables and measures how much information about one variable reduces uncertainty about another, providing a valuable perspective for extracting higher-level and interesting features from the data. The effectiveness of our method is evaluated on several model and real-world datasets, and its applicability is proven., Comment: IEEE Access (2024)
Published: 2024
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4. Kinetic temperature of massive star-forming molecular clumps measured with formaldehyde V. The massive filament DR21

Author: Zhao, X., Tang, X. D., Henkel, C., Gong, Y., Lin, Y., Li, D. L., He, Y. X., Ao, Y. P., Lu, X., Liu, T., Sun, Y., Wang, K., Chen, X. P., Esimbek, J., Zhou, J. J., Wu, J. W., Qiu, J. J., Zheng, X. W., Li, J. S., Luo, C. S., and Zhao, Q.
Subjects: Astrophysics - Astrophysics of Galaxies
Abstract: The kinetic temperature structure of the massive filament DR21 has been mapped using the IRAM 30 m telescope. This mapping employed the para-H$_2$CO triplet ($J_{\rm K_aK_c}$ = 3$_{03}$--2$_{02}$, 3$_{22}$--2$_{21}$, and 3$_{21}$--2$_{20}$) on a scale of $\sim$0.1 pc. By modeling the averaged line ratios of para-H$_{2}$CO with RADEX under non-LTE assumptions, the kinetic temperature of the dense gas was derived at a density of $n$(H$_{2}$) = 10$^{5}$ cm$^{-3}$. The para-H$_2$CO lines reveal significantly higher temperatures than NH$_3$ (1,1)/(2,2) and FIR wavelengths. The dense clumps appear to correlate with the notable kinetic temperature. Among the four dense cores (N44, N46, N48, and N54), temperature gradients are observed on a scale of $\sim$0.1-0.3 pc. This suggests that the warm dense gas is influenced by internal star formation activity. With the exception of N54, the temperature profiles of these cores were fitted with power-law indices ranging from $-$0.3 to $-$0.5. This indicates that the warm dense gas is heated by radiation emitted from internally embedded protostar(s) and/or clusters. While there is no direct evidence supporting the idea that the dense gas is heated by shocks resulting from a past explosive event in the DR21 region, our measurements toward the DR21W1 region provide compelling evidence that the dense gas is indeed heated by shocks originating from the western DR21 flow. Higher temperatures appear to be associated with turbulence. The physical parameters of the dense gas in the DR21 filament exhibit a remarkable similarity to the results obtained in OMC-1 and N113. This may imply that the physical mechanisms governing the dynamics and thermodynamics of dense gas traced by H$_{2}$CO in diverse star formation regions may be dominated by common underlying principles despite variations in specific environmental conditions. (abbreviated), Comment: 16 pages, 8 figures, 3 tabels. Accepted for publication by Astronomy & Astrophysics
Published: 2024
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5. Solar fusion III: New data and theory for hydrogen-burning stars

Author: Acharya, B., Aliotta, M., Balantekin, A. B., Bemmerer, D., Bertulani, C. A., Best, A., Brune, C. R., Buompane, R., Cavanna, F., Chen, J. W., Colgan, J., Czarnecki, A., Davids, B., deBoer, R. J., Delahaye, F., Depalo, R., García, A., Johnson, M. Gatu, Gazit, D., Gialanella, L., Greife, U., Guffanti, D., Guglielmetti, A., Hambleton, K., Haxton, W. C., Herrera, Y., Huang, M., Iliadis, C., Kravvaris, K., La Cognata, M., Langanke, K., Marcucci, L. E., Nagayama, T., Nollett, K. M., Odell, D., Gann, G. D. Orebi, Piatti, D., Pinsonneault, M., Platter, L., Robertson, R. G. H., Rupak, G., Serenelli, A., Sferrazza, M., Szücs, T., Tang, X., Tumino, A., Villante, F. L., Walker-Loud, A., Zhang, X., and Zuber, K.
Subjects: Astrophysics - Solar and Stellar Astrophysics, Astrophysics - High Energy Astrophysical Phenomena, Nuclear Experiment, Nuclear Theory
Abstract: In stars that lie on the main sequence in the Hertzsprung Russel diagram, like our sun, hydrogen is fused to helium in a number of nuclear reaction chains and series, such as the proton-proton chain and the carbon-nitrogen-oxygen cycles. Precisely determined thermonuclear rates of these reactions lie at the foundation of the standard solar model. This review, the third decadal evaluation of the nuclear physics of hydrogen-burning stars, is motivated by the great advances made in recent years by solar neutrino observatories, putting experimental knowledge of the proton-proton chain neutrino fluxes in the few-percent precision range. The basis of the review is a one-week community meeting held in July 2022 in Berkeley, California, and many subsequent digital meetings and exchanges. Each of the relevant reactions of solar and quiescent stellar hydrogen burning is reviewed here, from both theoretical and experimental perspectives. Recommendations for the state of the art of the astrophysical S-factor and its uncertainty are formulated for each of them. Several other topics of paramount importance for the solar model are reviewed, as well: recent and future neutrino experiments, electron screening, radiative opacities, and current and upcoming experimental facilities. In addition to reaction-specific recommendations, also general recommendations are formed., Comment: 85 pages, 15 figures. To be submitted to Reviews of Modern Physics
Published: 2024

6. Simplified integration of optimal self-management behaviors is associated with improved HbA1c in patients with type 1 diabetes

Author: Deng, C., Xie, Y., Liu, F., Tang, X., Fan, L., Yang, X., Chen, Y., Zhou, Z., and Li, X.
Published: 2024
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7. Stellar halo density with LAMOST K and M giants

Author: Lopez-Corredoira, M., Tang, X. -C., Tian, H., Wang, H. -F., Carraro, G., and Liu, C.
Subjects: Astrophysics - Astrophysics of Galaxies
Abstract: AIMS. We derive the morphology of the stellar component in the outer halo volume, and search for possible overdensities due to substructures therein. METHODS. We made use of some of the data releases of the spectroscopic survey LAMOST DR8-DR9 in tandem with distance determinations for two subsamples, that is, of K-giants and M-giants, respectively, making up 60,000 stars. These distance are obtained through Bayesian techniques that derive absolute magnitudes as a function of measured spectroscopic parameters. Our calculation of the density from these catalogues requires: (1) derivation of the selection function; and (2) a correction for the convolution of the distance errors, which we carried out with Lucy's inversion of the corresponding integral equation. RESULTS. The stellar density distribution of the outer halo (distance to the Galactic centre, $r_G$, of between 25 and 90 kpc) is a smooth monotonously decreasing function with a dependence of approximately $\rho \propto r_G^{-n}$, with $n=4.6\pm 0.4$ for K-giants and $n=4.5\pm 0.2$ for M-giants, and with a insignificant oblateness. The value of $n$ is independent of the angular distance to the Sagittarius tidal stream plane, which is what would be expected if such a stream did not exist in the anticenter positions or had a negligible imprint in the density distribution in the outer halo. Apart from random fluctuations or minor anomalies in some lines of sight, we do not see substructures superimposed in the outer halo volume within the resolution that we are using and limited by the error bars. This constrains the mass of over- and under-densities in the outer halo to be of $\lesssim 10^3$ M$_\odot $/deg$^2$, whereas the total mass of the stellar halo, including inner and outer parts, is $\sim 7\times 10^8$ M$_\odot $., Comment: 11 pages, 14 figures, accepted to be published in A&A
Published: 2024

8. ProCNS: Progressive Prototype Calibration and Noise Suppression for Weakly-Supervised Medical Image Segmentation

Author: Liu, Y., Lin, L., Wong, K. K. Y., and Tang, X.
Subjects: Computer Science - Computer Vision and Pattern Recognition, Computer Science - Machine Learning
Abstract: Weakly-supervised segmentation (WSS) has emerged as a solution to mitigate the conflict between annotation cost and model performance by adopting sparse annotation formats (e.g., point, scribble, block, etc.). Typical approaches attempt to exploit anatomy and topology priors to directly expand sparse annotations into pseudo-labels. However, due to a lack of attention to the ambiguous edges in medical images and insufficient exploration of sparse supervision, existing approaches tend to generate erroneous and overconfident pseudo proposals in noisy regions, leading to cumulative model error and performance degradation. In this work, we propose a novel WSS approach, named ProCNS, encompassing two synergistic modules devised with the principles of progressive prototype calibration and noise suppression. Specifically, we design a Prototype-based Regional Spatial Affinity (PRSA) loss to maximize the pair-wise affinities between spatial and semantic elements, providing our model of interest with more reliable guidance. The affinities are derived from the input images and the prototype-refined predictions. Meanwhile, we propose an Adaptive Noise Perception and Masking (ANPM) module to obtain more enriched and representative prototype representations, which adaptively identifies and masks noisy regions within the pseudo proposals, reducing potential erroneous interference during prototype computation. Furthermore, we generate specialized soft pseudo-labels for the noisy regions identified by ANPM, providing supplementary supervision. Extensive experiments on three medical image segmentation tasks involving different modalities demonstrate that the proposed framework significantly outperforms representative state-of-the-art methods
Published: 2024

9. Assessing the carrying capacity of Perinereis aibuhitensis in a Chinese estuarine wetland using a GIS-based habitat suitability index model

Author: Liu, C, Wang, Q, Zhao, W, Liu, H, Tang, X, Zhang, Z, and Zhou, J
Subjects: Aquaculture. Fisheries. Angling, SH1-691, Ecology, QH540-549.5
Abstract: Increasing attention is being paid to estuarine benthic community conservation and restoration globally. In this study, a GIS-based habitat suitability index (HSI) model was utilized to estimate Perinereis aibuhitensis (Grube, 1878) carrying capacity in estuarine wetlands of the Zhimai River, eastern China. Eight parameters were investigated, including sand content, salinity, pH, and petroleum hydrocarbon. Each parameter was investigated by a non-linear suitability function for transition from transformed parameter values into a normalized quality index. The weight of each parameter factor was determined by an analytic hierarchy process. A functional relationship was established between habitat suitability and population abundance to assess the carrying capacity. Twelve observation stations, divided into central, eastern, and western regions, were selected to collect data on biogeochemical and environmental parameters. These data were interpolated by GIS. The HSI model was then applied to obtain thematic maps of suitable habitat areas for P. aibuhitensis and corresponding carrying capacities. Results showed that central and western regions (approximately 1.013 km2, accounting for 66.38% of the total area) had a relatively high carrying capacity (130-150 ind. m-2), whereas the carrying capacity of the eastern region was below average. The abundance of P. aibuhitensis did not reach the carrying capacity of the environment under present conditions, especially in the eastern region. Results of the present study indicate that the execution of P. aibuhitensis restoration is feasible in this region; the areas around Stn 7 and in the eastern region are recommended for restoration.
Published: 2017
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10. Sulfur isotope ratios in the Large Magellanic Cloud

Author: Gong, Y., Henkel, C., Menten, K. M., Chen, C. -H. R., Zhang, Z. Y., Yan, Y. T., Weiss, A., Langer, N., Wang, J. Z., Mao, R. Q., Tang, X. D., Yang, W., Ao, Y. P., and Wang, M.
Subjects: Astrophysics - Astrophysics of Galaxies
Abstract: Sulfur isotope ratios have emerged as a promising tool for tracing stellar nucleosynthesis, quantifying stellar populations, and investigating the chemical evolution of galaxies. While extensively studied in the Milky Way, in extragalactic environments they remain largely unexplored. We focus on investigating the sulfur isotope ratios in the Large Magellanic Cloud (LMC) to gain insights into sulfur enrichment in this nearby system and to establish benchmarks for such ratios in metal-poor galaxies. We conducted pointed observations of CS and its isotopologues toward N113, one of the most prominent star-formation regions in the LMC, utilizing the Atacama Pathfinder EXperiment 12~m telescope. We present the first robust detection of C$^{33}$S in the LMC by successfully identifying two C$^{33}$S transitions on a large scale of $\sim$5 pc. Our measurements result in an accurate determination of the $^{34}$S/$^{33}$S isotope ratio, which is 2.0$\pm$0.2. Our comparative analysis indicates that the $^{32}$S/$^{33}$S and $^{34}$S/$^{33}$S isotope ratios are about a factor of 2 lower in the LMC than in the Milky Way. Our findings suggest that the low $^{34}$S/$^{33}$S isotope ratio in the LMC can be attributed to a combination of the age effect, low metallicity, and star formation history., Comment: 6 pages, 1 figures, 2 tables, accepted for publication in A&A, adjusted to the final version
Published: 2023
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11. The Efficacy and Safety of Bevacizumab Plus Anti-PD-1/PD-L1 Inhibitors in Combination with Hepatic Arterial Infusion Chemotherapy for Initially Unresectable Hepatocellular Carcinoma

Author: Tang X, Chen J, Peng W, Yang Z, Hu L, Ye Z, Fu Y, Hu D, Zhou Z, Chen M, Zhang Y, and Wang JC
Subjects: hepatocellular carcinoma, immune checkpoint inhibitor, bevacizumab, hepatic arterial infusion chemotherapy, adverse event, Immunologic diseases. Allergy, RC581-607
Abstract: Xiang Tang,1,2,&ast; Jinbin Chen,1,2,&ast; Wei Peng,1,2,&ast; Zhoutian Yang,1,2 Li Hu,1,2 Zhiwei Ye,1,2 Yizhen Fu,1,2 Dandan Hu,1,2 Zhongguo Zhou,1,2 Minshan Chen,1,2 Yaojun Zhang,1,2 Jun-Cheng Wang1,2 1State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, 510060, People’s Republic of China; 2Department of Liver Surgery, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, 510060, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Yaojun Zhang; Jun-Cheng Wang, Department of Liver Surgery, Sun Yat-sen University Cancer Center, 651 Dongfeng Road East, Guangzhou, Guangdong, 510060, People’s Republic of China, Email zhangyuj@sysucc.org.cn; wangjch@sysucc.org.cnObjection: To report the efficacy and safety of triple combination therapy with bevacizumab plus anti-PD-1 (BP1) or anti-PD-L1 inhibitors (BPL) combined with hepatic arterial infusion chemotherapy (HAIC) as a first-line treatment for initially unresectable hepatocellular carcinoma (uHCC).Methods: In this retrospective study, patients with initially uHCC received either BP1-HAIC or BPL-HAIC as first-line treatment. The primary endpoint was progression-free survival (PFS); secondary endpoints included overall survival (OS), objective response rate (ORR) and disease control rate (DCR).Results: Between January 2020 and December 2022, a total of 136 patients with initially uHCC received triple combination therapy, with 76 in the BP1-HAIC group and 60 in the BPL-HAIC group. The median PFS for the entire cohort was 11.1 months (95% CI, 8.0– 13.7 months), and the median OS was 22.4 months (95% CI, 21.3- not reached). Comparative analysis revealed no significant differences in PFS (HR, 0.91, P = 0.69) or OS (HR, 0.71, P = 0.31) between the BP1-HAIC and BPL-HAIC groups. The ORR was 46.3% per RECIST v1.1 and 66.9% per mRECIST, with a DCR of 83.1% under both criteria. Common adverse events (AEs) included hypoalbuminemia and elevated aspartate/alanine aminotransferase, with 5.1% (7/136) experienced upper gastrointestinal bleeding. Multivariate Cox analysis identified tumor number and BCLC stage as independent prognostic factors for OS, and tumor number for PFS.Conclusion: Triple combination therapy demonstrated significant therapeutic efficacy and tumor response in initially uHCC. No notable differences in outcomes were observed between the BP1-HAIC and BPL-HAIC groups. AEs were manageable in clinical practice.Keywords: hepatocellular carcinoma, immune checkpoint inhibitor, bevacizumab, hepatic arterial infusion chemotherapy, adverse event
Published: 2024

12. A Rare Case of Infective Endocarditis with Recurrent Fever Caused by Elizabethkingia anophelis

Author: Tang X, Liu Z, Li D, Xiong Y, Liao K, and Chen Y
Subjects: elizabethkingia anophelis, infective endocarditis, drug resistance, treatment, Infectious and parasitic diseases, RC109-216
Abstract: Xiuxin Tang,1,&ast; Zhiyun Liu,2,&ast; Danni Li,3 Yan Xiong,3 Kang Liao,1 Yili Chen1 1Department of Laboratory Medicine, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, People’s Republic of China; 2Department of Clinical Laboratory, Huizhou Central People ‘s Hospital, Huizhou, Guangdong, 516001, People’s Republic of China; 3Department of Emergency Medicine, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Yili Chen, Department of Laboratory Medicine, The First Affiliated Hospital of Sun Yat-sen University, No. 58 Zhongshan Er Road Guangzhou, Guangzhou, Guangdong Province, 510080, People’s Republic of China, Tel +8620-87330808-8461, Fax +8620-87330808, Email chenyli3@mail.sysu.edu.cnBackground: Elizabethkingia anophelis, an opportunistic pathogen that can cause infections in multiple parts of the human body, has multiple drug resistance and a high mortality rate. However, there have been few reports of infective endocarditis (IE) caused by Elizabethkingia anophelis, which means that diagnosis and treatment face challenges that cannot be ignored. Rapid and accurate identification and drug sensitivity results are needed to make timely treatment adjustments.Case Presentation: An 81-year-old man presented with recurrent fever and increased infection index for more than a month. Based on his clinical symptoms, infection index, reduplicative blood cultures, and results of transesophageal echocardiography, he was ultimately diagnosed with infective endocarditis caused by Elizabethkingia anophelis. The patient had a favorable outcome with a 6-week course of intravenous antibiotic therapy.Conclusion: This is a rare and successfully cured case of IE caused by the pathogen of Elizabethkingia anophelis, which is difficult not only in diagnosis but also in treatment. This case provides a certain referential significance to the treatment of Elizabethkingia anophelis-caused IE in clinical practice.Keywords: Elizabethkingia anophelis, infective endocarditis, drug resistance, treatment
Published: 2024

13. Elucidating the Mechanism of Large-Diameter Titanium Dioxide Nanotubes in Protecting Osteoblasts Under Oxidative Stress Environment: The Role of Fibronectin and Albumin Adsorption

Author: Xiang Y, Lin D, Zhou Q, Luo H, Zhou Z, Wu S, Xu K, Tang X, Ma P, Cai C, and Shen X
Subjects: osteoporosis, oxidative stress, titania nanotube, protein adsorption, osteogenesis., Medicine (General), R5-920
Abstract: Yun Xiang,1,2,&ast; Dini Lin,1,&ast; Qiang Zhou,1 Hongyu Luo,1 Zixin Zhou,1 Shuyi Wu,2 Keyuan Xu,2 Xiaoting Tang,1 Pingping Ma,2 Chunyuan Cai,1 Xinkun Shen1 1Wenzhou Key Laboratory for the Diagnosis and Prevention of Diabetic Complications, The Third Affiliated Hospital of Wenzhou Medical University (Ruian People’s Hospital), Wenzhou, 325016, People’s Republic of China; 2School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, 325027, People’s Republic of China&ast;These authors contributed equally to this work and share first authorshipCorrespondence: Xinkun Shen; Chunyuan Cai, Wenzhou Key Laboratory for the Diagnosis and Prevention of Diabetic Complications, The Third Affiliated Hospital of Wenzhou Medical University (Ruian People’s Hospital), Wenzhou, Zhejiang Province, 325016, People’s Republic of China, 108&num; Wansong Road, Email shenxinkun123@wmu.edu.cn; caichunyuan123@wmu.edu.cnBackground: Large-diameter titanium dioxide nanotubes (TNTs) have shown promise in preserving osteoblast function under oxidative stress (OS) in vitro. However, their ability to enhance osteogenesis in vivo under OS conditions and the underlying mechanisms remain unclear.Purpose: This study aimed to evaluate the osteogenic potential of 110 nm TNTs (TNT110) compared to 30 nm TNTs (TNT30) in an aging rat model exhibiting OS, and to investigate the mechanisms involved.Methods: Surface properties of TNTs were characterized, and in vitro and in vivo experiments were conducted to assess their osteoinductive effects under OS. Transcriptomic, proteomic analyses, and Western blotting were performed to investigate the protective mechanisms of TNT110 on osteoblasts. Protein adsorption studies focused on the roles of fibronectin (FN) and albumin (BSA) in modulating osteoblast behavior on TNT110.Results: In both in vitro and in vivo experiments, TNT110 significantly improved new bone formation and supported osteoblast survival under OS conditions. Subsequent ribonucleic acid sequencing results indicated that TNT110 tended to attenuate inflammatory responses and reactive oxygen species (ROS) expression while promoting endoplasmic reticulum (ER) stress and extracellular matrix receptor interactions, all of which are crucial for osteoblast survival and functionality. Further confirmation indicated that the cellular behavior changes of osteoblasts in the TNT110 group could only occur in the presence of serum. Moreover, proteomic analysis under OS conditions revealed the pivotal roles of FN and BSA in augmenting TNT110’s resistance to OS. Surface pretreatment of TNT110 with FN/BSA alone could beneficially influence the early adhesion, spreading, ER activity, and ROS expression of osteoblasts, a trend not observed with TNT30.Conclusion: TNT110 effectively protects osteoblast function in the OS microenvironment by modulating protein adsorption, with FN and BSA synergistically enhancing osteogenesis. These findings suggest TNT110’s potential for use in implants for elderly patients.Keywords: osteoporosis, oxidative stress, titania nanotube, protein adsorption, osteogenesis
Published: 2024

14. Pediatric Acute Myeloid Leukemia: Unraveling Complexities in Intensive Chemotherapy and the Emergence of Superbugs – A Case Study

Author: Patil S, Li X, Mai H, Wang Y, Tang X, Liu S, and Wen F
Subjects: acute myeloid leukaemia, carbapenem-resistant pseudomonas aeruginosa, paediatric oncology, antimicrobial resistance, superbugs, Infectious and parasitic diseases, RC109-216
Abstract: Sandip Patil, Xinye Li, Huirong Mai, Ying Wang, Xue Tang, Sixi Liu, Feiqiu Wen Department of Haematology and Oncology, Shenzhen Children’s Hospital, Shenzhen, Guangdong Province, People’s Republic of ChinaCorrespondence: Sixi Liu; Feiqiu Wen, Email tigar467@126.com; fwen62@163.comBackground: This case report underscores the intricate challenges in managing paediatric patients with acute myeloid leukaemia (AML) undergoing intensive chemotherapy, particularly when complicated by the emergence of multidrug-resistant pathogens such as Carbapenem-Resistant Pseudomonas aeruginosa (CRPA).Case Presentation: An 11-year-old male with AML presented with skin purpura and persistent cough. Clinical and laboratory assessments revealed a high-risk AML profile with genetic mutations, leading to the initiation of intensive chemotherapy per the C-HUANA-AML-2015 protocol. Despite successful disease remission after initial chemotherapy courses, the patient experienced unexpected complications. Notably, septic shock, bone marrow failure, and the emergence of CRPA were encountered during the clinical course. Septic shock occurred following Course B3 chemotherapy, marked by a fever unresponsive to initial antibiotic therapy. Despite negative blood cultures, meropenem and vancomycin were initiated, successfully normalizing temperature. Subsequent challenges included persistent bone marrow suppression, perianal dermatitis, and the identification of CRPA in stool cultures, leading to altered antibiotic therapy guided by minimum inhibitory concentration (MIC) considerations. Whole-genome sequencing (WGS) of the CRPA strain revealed a highly virulent clone (ST-970) with numerous resistance and virulence genes.Conclusion: This case report offers new insights into the complexities of pediatric AML management, with a focus on the emergence of CRPA. The discovery of a high-risk CRPA clone with detailed genomic data underscores the growing challenge of antimicrobial resistance in pediatric oncology. The persistent presence of CRPA and ongoing bone marrow failure highlight the difficulties in managing these complications. This case calls for a reassessment of treatment strategies and encourages further research to improve outcomes in pediatric AML, emphasizing the need for a multidisciplinary approach to address infectious complications and antimicrobial resistance.Keywords: acute myeloid leukaemia, carbapenem-resistant Pseudomonas aeruginosa, paediatric oncology, antimicrobial resistance, superbugs
Published: 2024

15. A Gluconeogenesis-Related Genes Model for Predicting Prognosis, Tumor Microenvironment Infiltration, and Drug Sensitivity in Hepatocellular Carcinoma

Author: Tang X, Xue J, Zhang J, and Zhou J
Subjects: hepatocellular carcinoma, gluconeogenesis metabolism, prognostic model, tumor microenvironment infiltration, drug sensitivity, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract: Xilong Tang,1,2 Jianjin Xue,1,2 Jie Zhang,2 Jiajia Zhou1,2 1Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, People’s Republic of China; 2Department of Surgery, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, People’s Republic of ChinaCorrespondence: Jiajia Zhou, Department of Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 510120, People’s Republic of China, Email zhoujj29@mail.sysu.edu.cnBackground: Hepatocellular carcinoma (HCC) is a prevalent malignancy within the digestive system, known for its poor prognosis. Gluconeogenesis, a critical metabolic pathway, is responsible for the synthesis of glucose in the normal liver. This study aimed to examine the role of gluconeogenesis-related genes (GRGs) in HCC and evaluate their impact on the tumor microenvironment infiltration and drug sensitivity in HCC.Methods: We retrieved gene expression and clinical pathological data of HCC from The Cancer Genome Atlas (TCGA) database. This dataset was utilized to develop a prognosis model. The data from The International Cancer Genome Consortium (ICGC) served as an independent validation cohort. A least absolute shrinkage and selection operator (LASSO) regression analysis was applied to a curated panel of GRGs to construct and validate the predictive model. Furthermore, unsupervised consensus clustering, based on the expression levels of GRGs, categorized HCC patients into distinct subgroups.Results: A four-gene prognostic model, referred to as GRGs, has been successfully developed with high accuracy and stability for the prediction of HCC patient prognosis. This model enables the stratification of patients into high or low risk groups based on individual risk scores, revealing significant differences in immune infiltration patterns and anti-tumor drug responses. Unsupervised consensus clustering analysis delineated four distinct subgroups of patients, each characterized by a unique prognosis and tumor immune microenvironment (TIME).Conclusion: This study is the first to develop a prognostic model incorporating 4-GRGs that effectively predicts the prognosis, tumor microenvironment infiltration, and drug sensitivity in HCC patients. The model based on 4 GRGs may contribute to predict the prognosis, immunotherapy and chemotherapy response of HCC patients.Keywords: hepatocellular carcinoma, gluconeogenesis metabolism, prognostic model, tumor microenvironment infiltration, drug sensitivity
Published: 2024

16. Endoscopic Joint Capsule and Articular Process Excision for the Treatment of Lumbar Facet Joint Syndrome: A Retrospective Study

Author: Tang X, Yuan H, Huang X, Xiao S, Ji Y, Zhou Y, Fu H, Lu J, Wang M, and Ma K
Subjects: endoscopic, lumbar facet joint syndrome, synovial entrapment, joint capsule, radiofrequency, vas, odi, Medicine (General), R5-920
Abstract: Xiaoxing Tang,1,&ast; Hongjie Yuan,2,&ast; Xuehua Huang,2 Shilin Xiao,2 Yun Ji,2 Yanjing Zhou,1 Hongbo Fu,3 Jingfeng Lu,4 Mingkai Wang,5 Ke Ma2 1Department of Radiology, Nantong Hospital of Traditional Chinese Medicine, Nantong, Jiangsu Province, People’s Republic of China; 2Department of Algology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People’s Republic of China; 3Department of Algology, Nantong Hospital of Traditional Chinese Medicine, Nantong, Jiangsu Province, People’s Republic of China; 4Department of Neurosurgery, Haian People’s Hospital, Nantong, Jiangsu Province, People’s Republic of China; 5Pharmacy Department, Nantong Elderly Rehabilitation Hospital, Nantong, Jiangsu Province, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Ke Ma, Department of Algology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, 1665 Kongjiang Road, Shanghai, 200092, People’s Republic of China, Email marke72@163.comBackground: Dorsal ramus medial branch radiofrequency ablation is reported to be effective for refractory lumbar facet joint syndrome. However, as nerve fibers can regenerate, the therapeutic effect was reported to be short and last only 6 to 12 months. Previously, we reported a novel endoscopic joint capsule and articular process excision procedure. In that case, a satisfying effect was achieved by removing the culprit hyperplastic articular synovial entrapped in the joint space endoscopically. We presume this treatment is an etiologic treatment and can exert longer-term efficacy.Aim: This retrospective clinical trial aimed to elucidate the longer-term efficacy as well as the safety profile of the procedure.Methods: This was a retrospective descriptive study. The participants underwent endoscopic joint capsule and articular process excision procedures. The Oswestry Disability Index (ODI) and Visual Analogue Scale (VAS) before the operation, and at 3 months, 6 months, 1 year, and 2 years post-operation were recorded by reviewing medical charts and conducting telephone interviews.Results: A total of 234 participants were evaluated in the trial. After participant screening, 13 participants were included in the final analysis. The VAS score was reduced from (median (P25, P75)) 6 (4.5, 6) at pre-operation to 2 (0, 4) at 1-year post-operation and 0 (0, 1) at 2-year pre-operation. The ODI score was reduced from 37.78 (27.09, 59.95) at pre-operation to 8.89 (2.22, 24.34) at 1-year post-operation and 6 (0.02, 11.11) at 2-year post-operation. The difference was statistically significant. Further subgroup analysis demonstrated that a narrowed intervertebral space was a possible relevant factor for poor outcomes. No procedure-related complications were reported.Conclusion: Endoscopic joint capsule and articular process excision is an effective and safe procedure for refractory lumbar facet joint syndrome. The effectiveness duration can last up to 1 to 2 years.Keywords: endoscopic, lumbar facet joint syndrome, synovial entrapment, joint capsule, radiofrequency, VAS, ODI
Published: 2024

17. Validation of the Athens Insomnia Scale Among Young Chinese Male Population in a High-Altitude Situation

Author: Tang X, Wang Q, Li S, Li X, Xin Q, and Yang Y
Subjects: athens insomnia scale, high altitude, internal consistency, reliability, sleep, validity, Psychiatry, RC435-571, Neurophysiology and neuropsychology, QP351-495
Abstract: Xugang Tang,1 Qiang Wang,1 Shuang Li,1 Xiuchuan Li,1 Qian Xin,2 Yongjian Yang1 1Department of Cardiology, The General Hospital of Western Theater Command, Chengdu, Sichuan, People’s Republic of China; 2Department of Cardiology, The Sixth Medical Center of Chinese PLA General Hospital, Beijing, People’s Republic of ChinaCorrespondence: Yongjian Yang, Department of Cardiology, The General Hospital of Western Theater Command, Chengdu, Sichuan, People’s Republic of China, Tel/Fax +86 28 8657 1255, Email yyjcdzyy@sina.comPurpose: The Athens Insomnia Scale (AIS) is a widely used and authorized questionnaire for evaluating insomnia symptoms. However, its reliability and validity at high altitudes are uncertain. Therefore, this study aimed to confirm the validity and reliability of AIS during a 3658 m altitude exposure.Patients and Methods: A total of 387 young Chinese males were enlisted in the acute high-altitude exposure group. They flew for about two hours, climbing from 400 m to 3658 m. The high-altitude-acclimated group consisted of 86 young Chinese men who had lived at least six months at 3658 m altitude. The sleep quality of the acute high-altitude exposure group was evaluated using the AIS before the ascent and after exposure to 3658 m for 24 hours, and one week. The sleep quality of the high-altitude-acclimated group was also assessed. The AIS’s internal consistency, reliability, and validity were evaluated.Results: The respondents’ quality of sleep significantly decreased after being exposed to 3658 m as opposed to 400 m. Two factors comprised the AIS, according to an exploratory factor analysis: “sleep problem” (items 1– 5) and “daytime dysfunction” (items 6– 8). The Cronbach’s α internal consistency coefficients exceeded 0.8, and the corrected item-total correlations were all greater than 0.5 when the subjects were exposed to 3658 m. The model fit index was well within the criterion. The average variance extracted and composite reliability were all higher than 0.5 and 0.7, respectively. The interclass correlation coefficient was deemed “fair to good” at 0.482, which is greater than the 0.4 threshold. The AIS has satisfactory discriminant validity, as shown by the Fornell-Larcker criterion and cross-loading results. The daytime dysfunction R-square values (> 0.33) show that the frameworks have considerable predictive accuracy.Conclusion: The AIS exhibits strong consistency, reliability, and validity. The AIS’s features and simplicity make it an essential psychometric tool for high-altitude sleep research.Keywords: athens insomnia scale, high altitude, internal consistency, reliability, sleep, validity
Published: 2024

18. Protonated hydrogen cyanide as a tracer of pristine molecular gas

Author: Gong, Y., Du, F. J., Henkel, C., Jacob, A. M., Belloche, A., Wang, J. Z., Menten, K. M., Yang, W., Quan, D. H., Bop, C. T., Ortiz-León, G. N., Tang, X. D., Rugel, M. R., and Liu, S.
Subjects: Astrophysics - Astrophysics of Galaxies
Abstract: Protonated hydrogen cyanide, HCNH$^{+}$, plays a fundamental role in astrochemistry because it is an intermediary in gas-phase ion-neutral reactions within cold molecular clouds. However, the impact of the environment on the chemistry of HCNH$^{+}$ remains poorly understood. With the IRAM-30 m and APEX-12 m observations, we report the first robust distribution of HCNH$^{+}$ in the Serpens filament and in Serpens South. Our data suggest that HCNH$^{+}$ is abundant in cold and quiescent regions, but is deficit in active star-forming regions. The observed HCNH$^{+}$ fractional abundances relative to H$_{2}$ range from $3.1\times 10^{-11}$ in protostellar cores to $5.9\times 10^{-10}$ in prestellar cores, and the HCNH$^{+}$ abundance generally decreases with increasing H$_{2}$ column density, which suggests that HCNH$^{+}$ coevolves with cloud cores. Our observations and modeling results suggest that the abundance of HCNH$^{+}$ in cold molecular clouds is strongly dependent on the H$_{2}$ number density. The decrease in the abundance of HCNH$^{+}$ is caused by the fact that its main precursors (e.g., HCN and HNC) undergo freeze-out as the number density of H$_{2}$ increases. However, current chemical models cannot explain other observed trends, such as the fact that the abundance of HCNH$^{+}$ shows an anti-correlation with that of HCN and HNC, but a positive correlation with that of N$_{2}$H$^{+}$ in the southern part of the Serpens South northern clump. This indicates that additional chemical pathways have to be invoked for the formation of HCNH$^{+}$ via molecules like N$_{2}$ in regions in which HCN and HNC freeze out. Both the fact that HCNH$^{+}$ is most abundant in molecular cores prior to gravitational collapse and the fact that low-$J$ HCNH$^{+}$ transitions have very low H$_{2}$ critical densities make this molecular ion an excellent probe of pristine molecular gas., Comment: 25 pages, 26 figures, accepted for publication in A&A
Published: 2023
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19. A long short-term memory neural network-based error estimator for three-dimensional dynamically adaptive mesh generation

Author: Wu, X., Gan, P., Li, J., Fang, F., Zou, X., Pain, C. C, Tang, X., Xin, J., Wang, Z., and Zhu, J.
Published: 2023

20. Effects of Bulleyaconitine A on Extracellular Matrix Secretion and Expression of Related Proteins in Acetaldehyde-Activated Hepatic Stellate Cells

Author: Song, Q. W., Yuan, Y. P., Sun, Q. S., Zhan, X. D., Jiang, Y. X., and Tang, X. N.
Published: 2024
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21. NvDEx-100 Conceptual Design Report

Author: Cao, X., Chang, Y., Chen, K., Ciuffoli, E., Duan, L., Fang, D., Gao, C., Ghorui, S. K., Hu, P., Hu, Q., Huang, S., Huang, Z., Lang, L., Li, Y., Li, Z., Liang, T., Liu, J., Lu, C., Mai, F., Mei, Y., Qiu, H., Sun, X., Tang, X., Wang, H., Wang, Q., Xiao, L., Xiao, M., Xin, J., Xu, N., Yang, P., Yang, Y., Yang, Z., Yu, Z., Zhang, D., Zhang, J., Zhao, C., and Zhu, D.
Subjects: Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract: Observing nuclear neutrinoless double beta (0vbb) decay would be a revolutionary result in particle physics. Observing such a decay would prove that the neutrinos are their own antiparticles, help to study the absolute mass of neutrinos, explore the origin of their mass, and may explain the matter-antimatter asymmetry in our universe by lepton number violation. We propose developing a time projection chamber (TPC) using high-pressure 82SeF6 gas and top-metal silicon sensors for read-out in the China Jinping Underground Laboratory (CJPL) to search for neutrinoless double beta decay of 82Se, called the NvDEx experiment. Besides being located at CJPL with the world's thickest rock shielding, NvDEx combines the advantages of the high Qbb (2.996 MeV) of 82Se and the TPC's ability to distinguish signal and background events using their different topological characteristics. This makes NvDEx unique, with great potential for low-background and high-sensitivity 0vbb searches. NvDEx-100, a NvDEx experiment phase with 100 kg of SeF6 gas, is being built, with plans to complete installation at CJPL by 2025. This report introduces 0vbb physics, the NvDEx concept and its advantages, and the schematic design of NvDEx-100, its subsystems, and background and sensitivity estimation.
Published: 2023
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22. Treatment Outcomes and Associated Influencing Factors Among Patients with Rifampicin-Resistant Tuberculosis: A Multicenter, Retrospective, Cohort Study in China

Author: Zou L, Kang W, Guo C, Du J, Chen Q, Shi Z, Tang X, Liang L, Tang P, Pan Q, Zhu Q, Yang S, Chang Z, Guo Z, Wu G, and Tang S
Subjects: rr-tb, treatment outcomes, influencing factors, china, Infectious and parasitic diseases, RC109-216
Abstract: Liping Zou,1,&ast; Wanli Kang,2,&ast; Chunhui Guo,3,&ast; Juan Du,4,&ast; Qing Chen,1 Zhengyu Shi,1 Xianzhen Tang,1 Li Liang,1 Peijun Tang,5 Qing Pan,6 Qingdong Zhu,7 Song Yang,8 Zhanlin Chang,9 Zhouli Guo,1 Guihui Wu,1 Shenjie Tang2 1Department of Tuberculosis, Public Health Clinical Center of Chengdu, Chengdu, People’s Republic of China; 2Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing, People’s Republic of China; 3Department of Tuberculosis, Harbin Chest Hospital, Harbin, People’s Republic of China; 4Department of Tuberculosis, Wuhan Pulmonary Hotel, Wuhan, People’s Republic of China; 5Department of Tuberculosis, the Fifth People’s Hospital of Suzhou, Suzhou, People’s Republic of China; 6Department of Respiratory and Critical Care Medicine, Anqing Municipal Hospital, Anqing, People’s Republic of China; 7Department of Tuberculosis, the Fourth People’s Hospital of Nanning, Nanning, People’s Republic of China; 8General Internal Medicine Department, Chongqing Public Health Medical Center, Chongqing, People’s Republic of China; 9Department of Surgery, the Third People’s Hospital of Tibet Autonomous Region, Lasa, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Guihui Wu, Department of Tuberculosis, Public Health Clinical Center of Chengdu, Jingjusi 18 Street, Jingjiang District, Chengdu, Sichuan, People’s Republic of China, Tel +86-28-8455-0573, Email wghwgh2584@sina.com Shenjie Tang, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing, 101149, People’s Republic of China, Tel +86-13621028338, Email tangsj1106@vip.sina.comObjective: Rifampin-resistant tuberculosis (RR-TB) remains a serious global public health concern. We assessed treatment outcomes and associated influencing factors among RR-TB patients in China.Methods: This research enrolled 1339 patients who started RR-TB treatment between May 2018 and April 2020 in China retrospectively. Data were collected from the electronic medical records. Multivariable logistic regression analysis was used to identify the influencing factors related to unfavorable outcomes.Results: Of the 1339 RR-TB patients, 78.8% (1055/1339) achieved treatment success (cured or treatment completed), 5.1% (68/1339) experienced treatment failure, 1.1% (15/1339) died during treatment, 10.1% (135/1339) were lost to follow-up, and 4.9% (66/1339) were not evaluated. About 67.7% (907/1339) of patients experienced at least one adverse event (AE). The most common AE was hypohepatia (507/1339, 37.9%), followed by hyperuricemia (429/1339, 32.0%), anemia (368/1339, 27.5%), electrolyte disturbance (318/1339, 23.7%), peripheral neuritis (245/1339, 18.3%), and gastrointestinal reactions (203/1339, 15.2%). Multivariate analysis showed that age ≥ 60 years [adjusted odds ratio (aOR): 1.96, 95% confidence interval (CI): 1.39– 2.77], national minority (aOR: 2.36, 95% CI: 1.42– 3.93), smoking (aOR: 1.50, 95% CI: 1.10– 2.04), cardiopathy (aOR: 2.90, 95% CI: 1.33– 6.31), tumors (aOR: 9.84, 95% CI: 2.27– 42.67), immunocompromise (aOR: 2.17, 95% CI: 1.21– 3.91), re-treated TB (aOR: 1.46, 95% CI: 1.08– 1.97), and experienced gastrointestinal reactions (aOR: 2.27, 95% CI: 1.52– 3.40) were associated with unfavorable outcomes. Body mass index (BMI) ≥ 18.5 kg/m2, regimens containing bedaquiline and experienced adverse events (AEs) such as hypohepatia, leukopenia, peripheral neuritis, and optic neuritis were associated with favorable outcomes.Conclusion: High rates of treatment success were achieved for RR-TB patients at tertiary tuberculosis hospitals in China. Age ≥ 60 years, national minority, smoking status, comorbidities, re-treated TB, and experienced gastrointestinal reactions were independent prognostic factors for unfavorable treatment outcomes.Keywords: RR-TB, treatment outcomes, influencing factors, China
Published: 2024

23. Evaluation of Postoperative Discomfort After Strabismus Surgery Under General Anesthesia in Children: A Prospective Observational Study

Author: Mo Y, Zhang W, Tang X, Zhang R, Wang Y, and Zheng L
Subjects: strabismus surgery, discomfort, postoperative nausea, vomiting, general anesthesia, Medicine (General), R5-920
Abstract: Yawen Mo,1,&ast; Wenjuan Zhang,1,&ast; Xiangcheng Tang,1 Rui Zhang,2 Yinghuan Wang,1 Lingling Zheng3 1Department of Strabismus and Amblyopia, State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, People’s Republic of China; 2Department of Anesthesia, State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, People’s Republic of China; 3Department of Nursing Administration, State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Lingling Zheng, State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, 7 Jinsui Road, Guangzhou, People’s Republic of China, Email zhenglingling@gzzoc.comPurpose: Strabismus surgery is most commonly performed on children under general anesthesia. However, few studies have focused on the postoperative discomfort in children after strabismus surgery. This study aimed to evaluate postoperative discomfort and the associated risk factors in children who underwent strabismus surgery under general anesthesia.Patients and Methods: A single-center prospective observational study including 300 children who underwent strabismus surgery after general anesthesia was conducted. Patients’ characteristics, preoperative anxiety, surgical and anesthesia data, discomfort within 24 hours after postanesthesia care unit were recorded. The primary outcome was the incidence of postoperative discomfort.Results: Approximately 51.33% of the children complained of at least one of the following types of postoperative discomfort: postoperative nausea and vomiting (PONV) (23.00%), headache (4.33%), dizziness (20.33%) and emergence agitation (EA) (5.33%). Multivariate analysis indicated that history of motion sickness (P< 0.001, odds ratio [OR]=3.72), and surgery in the dominant eye (P=0.010, OR=2.00) were independent predictors of postoperative discomfort; age was an independent predictor of EA (P< 0.001, OR=0.36); prism diopter≥ 40 was an independent predictor of headache (P=0.005, OR=5.53); age (P=0.020, OR=1.12) and history of motion sickness (P=0.001, OR=2.80) were independent predictors of dizziness; history of motion sickness (P=0.001, OR=2.63) and surgery of inferior oblique anterior transposition (IOAT) (P=0.004, OR=3.10) were independent predictors of PONV.Conclusion: The most frequent postoperative symptoms in children after undergoing strabismus surgery under general anesthesia are PONV, dizziness, EA, and headache. Younger age, larger angle of strabismus, history of motion sickness, surgery on the dominant eye, and surgery of IOAT may be additional risk factors for postoperative discomfort.Keywords: strabismus surgery, discomfort, postoperative nausea, vomiting, general anesthesia
Published: 2024

24. Associations of HDL-C and ApoA-I with Mortality Risk in PCI Patients Across Different hsCRP Levels

Author: Yan K, Li J, Zhu P, Tang X, Li Y, Yang Y, Gao R, Yuan J, and Zhao X
Subjects: apolipoprotein a-i, high-density lipoprotein-cholesterol, inflammation, mortality, percutaneous coronary intervention, Pathology, RB1-214, Therapeutics. Pharmacology, RM1-950
Abstract: Kailun Yan, Jiawen Li, Pei Zhu, Xiaofang Tang, Yulong Li, Yuejin Yang, Runlin Gao, Jinqing Yuan, Xueyan Zhao National Clinical Research Center for Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, People’s Republic of ChinaCorrespondence: Xueyan Zhao; Jinqing Yuan, National Clinical Research Center for Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, People’s Republic of China, Tel +86-10-88322451, Fax +86-10-68351786, Email zhao_xueyan@sina.com; jqyuanfw@163.comPurpose: The association between high-density lipoprotein cholesterol (HDL-C) and apolipoprotein A-I (ApoA-I) and cardiovascular risk in patients with coronary artery disease remains inconsistent. Recent investigations indicated potential dysfunctionality of HDL under inflammation. This study endeavors to explore whether the inflammatory status modifies the effects of HDL-C and ApoA-I on cardiovascular risk in individuals with percutaneous coronary intervention (PCI).Patients and Methods: Consecutive 10,724 PCI patients at Fuwai hospital in 2013 were enrolled. Inflammation status was defined by high-sensitivity C-reactive proteins (hsCRP) ≥ 2 mg/L. The study endpoint was cardiac mortality.Results: Among 9569 PCI patients eventually included, 225 (2.4%) cardiac mortality happened during 5 years. In hsCRP ≥ 2 mg/L group, an U-shaped curve was observed for HDL-C and multivariate Cox regression showed that elevated risks of cardiac mortality correlated to both the lowest quintile (hazard ratio [HR], 2.50; 95% confidence interval [CI], 1.32– 4.71) and the highest quintile of HDL-C (HR, 2.28; 95% CI, 1.23– 4.25). However, an L-shaped curve existed in ApoA-I, indicating only the lowest quintile level of ApoA-I was associated with an increased cardiac mortality risk (HR, 2.19; 95% CI, 1.28– 3.75). Nevertheless, in hsCRP < 2 mg/L group, no significant correlations between HDL-C and ApoA-I and cardiac mortality risk were identified (both P > 0.05).Conclusion: In PCI patients with hsCRP ≥ 2 mg/L. both low and high HDL-C levels correlated with higher cardiac mortality risk (U-shaped), while only low ApoA-I levels were linked to elevated risk (L-shaped). However, in patients with hsCRP < 2 mg/L, neither HDL-C nor ApoA-I levels were associated with higher cardiac mortality risk. These findings shed light on the importance of considering inflammation status, particularly hsCRP levels, in managing HDL-C and ApoA-I levels, and suggest targeting elevated ApoA-I levels as a potential therapeutic approach for PCI patients with hsCRP ≥ 2 mg/L. Keywords: apolipoprotein A-I, high-density lipoprotein-cholesterol, inflammation, mortality, percutaneous coronary intervention
Published: 2024

25. Rate and Associated Factors of Fatigue in Chinese Patients with Non-Alcoholic Fatty Liver Disease: A Cross-Sectional Survey

Author: Du X, Hu J, Xue J, Zhuang Y, Tang X, and Xu Z
Subjects: non-alcoholic fatty liver disease, fatigue, exercise, anxiety, sleep, Medicine (General), R5-920
Abstract: Xian Du,1,&ast; Jun Hu,1,&ast; Jianhua Xue,1 Yuan Zhuang,2 Xuefeng Tang,1 Zhiyue Xu1 1Health Examination Center, Shanghai Health and Medical Center (Huadong Sanatorium), Wuxi, People’s Republic of China; 2The Affiliated Hospital of Nantong University, Nantong, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Zhiyue Xu; Xuefeng Tang, Health Examination Center, Shanghai Health and Medical Center (Huadong Sanatorium), 67 Dajishan, Wuxi, 214065, People’s Republic of China, Email hepenxiaozi@163.com; 978665164@qq.comPurpose: Fatigue was a common symptom of non-alcoholic fatty liver disease (NAFLD), which seriously affected patients’ quality of life. The aim of this study was to detect fatigue rate and to evaluate factors associated with fatigue in NAFLD patients.Patients and Methods: A cross-sectional study was carried out from the Huadong Sanatorium between April 2022 and May 2023, and 133 NAFLD patients were included in this study. They completed Fatigue Severity Scale to assess fatigue, the Hospital Anxiety and Depression Scale to estimate psychological status, and the Pittsburgh Sleep Quality Index for sleep quality. Data were analyzed by independent samples t-tests, χ 2 tests and logistic regression models.Results: We found that 51.1% of NAFLD patients had fatigue. Exercise, anxiety, depression, subjective sleep quality, sleep latency, sleep duration, habitual sleep efficiency, sleep disorders, daytime dysfunction and overall sleep quality were related to fatigue among NAFLD patients. Moreover, logistic regression models indicated anxiety, habitual sleep efficiency and sleep disorders as important predictors of fatigue.Conclusion: This was the first time to explore demographic, clinical, psychological and sleeping correlated factors for fatigue in Chinese NAFLD patients. Our study showed that more than half of NAFLD patients had fatigue, and anxiety, habitual sleep efficiency and sleep disorders were significantly associated with fatigue in NAFLD. The findings indicated that it was very necessary to pay more attention to fatigue of NAFLD patients, especially those with negative emotions and poor sleep quality by favorable intervention to relieve fatigue symptoms, so as to improve quality of life.Keywords: non-alcoholic fatty liver disease, fatigue, exercise, anxiety, sleep
Published: 2024

26. Dual-Targeted Zeolitic Imidazolate Frameworks Drug Delivery System Reversing Cisplatin Resistance to Treat Resistant Ovarian Cancer

Author: Xing Y, Jing R, Tang X, and Jiang Z
Subjects: ovarian cancer, drug resistance, targeted therapy, folic acid, zif-90, nanomedicine, mitochondria, cell apoptosis, Medicine (General), R5-920
Abstract: Yan Xing,1,&ast; Rui Jing,2,&ast; Xiaoying Tang,2 Zhenqi Jiang2 1Department of Gynecology, The First Affiliated Hospital of Ningbo University, Ningbo, People’s Republic of China; 2School of Medical Technology, Beijing Institute of Technology, Beijing, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Zhenqi Jiang; Xiaoying Tang, Email jiangzhenqi@bit.edu.cn; xiaoying@bit.edu.cnObjective: Ovarian cancer cells are prone to acquire tolerance to chemotherapeutic agents, which seriously affects clinical outcomes. The development of novel strategies to enhance the targeting of chemotherapeutic agents to overcome drug resistance and minimize side effects is significant for improving the clinical outcomes of ovarian cancer patients.Methods: We employed folic acid (FA)-modified ZIF-90 nanomaterials (FA-ZIF-90) to deliver the chemotherapeutic drug, cisplatin (DDP), via dual targeting to improve its targeting to circumvent cisplatin resistance in ovarian cancer cells, especially by targeting mitochondria. FA-ZIF-90/DDP could rapidly release DDP in response to dual stimulation of acidity and ATP in tumor cells.Results: FA-ZIF-90/DDP showed good blood compatibility. It was efficiently taken up by human ovarian cancer cisplatin-resistant cells A2780/DDP and aggregated in the mitochondrial region. FA-ZIF-90/DDP significantly inhibited the mitochondrial activity and metastatic ability of A2780/DDP cells. In addition, it effectively induced apoptosis in A2780/DDP cells and overcame cisplatin resistance. In vivo experiments showed that FA-ZIF-90/DDP increased the accumulation of DDP in tumor tissues and significantly inhibited tumor growth.Conclusion: FA-modified ZIF-90 nanocarriers can improve the tumor targeting and anti-tumor effects of chemotherapeutic drugs, reduce toxic side effects, and are expected to be a novel therapeutic strategy to reverse drug resistance in ovarian cancer.Keywords: ovarian cancer, drug resistance, targeted therapy, folic acid, ZIF-90, nanomedicine, mitochondria, cell apoptosis
Published: 2024

27. Significance of Nutritional-Inflammatory Index as Predictors for Total Neoadjuvant Therapy-Induced Tumor Regression in Locally Advanced Rectal Cancer Patients

Author: Zhao Z, Yan M, Pang H, Chen L, Tang X, Chen Z, Chen X, and Sun H
Subjects: rectal cancer, total neoadjuvant therapy, halp, tumor regression., Pathology, RB1-214, Therapeutics. Pharmacology, RM1-950
Abstract: Zhou Zhao,1,2,&ast; Menghua Yan,1,&ast; Huayang Pang,1,2 Lihui Chen,1 Xi Tang,1 Zhixiong Chen,1 Xiufeng Chen,1 Hao Sun1 1Gastrointestinal Cancer Center, Chongqing University Cancer Hospital, Chongqing, 400030, People’s Republic of China; 2Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing University Cancer Hospital, Chongqing, 400030, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Hao Sun; Xiufeng Chen, Gastrointestinal Cancer Center, Chongqing University Cancer Hospital, No. 181 of Hanyu Road, Chongqing, 400030, People’s Republic of China, Email sunhao_med@cqu.edu.cn; sunhao68@sina.com; 13028399392@163.comPurpose: To evaluate the predictive capacity of the nutritional-inflammatory index and clinicopathological characteristics in patients with locally advanced rectal cancer (LARC) receiving total neoadjuvant therapy (TNT).Methods: Data from 127 patients with LARC receiving TNT from January 2017 to January 2021 were retrospectively analyzed. Clinicopathological characteristics with different TNT-induced responses were compared. The Chi-square test and the Mann–Whitney test were used to analyze the association between pre-TNT factors and TNT-induced responses. Multivariable logistic regression analysis was used to construct a predictive model.Results: In the cohort of 127 patients with LARC who underwent total neoadjuvant therapy (TNT), the mean age was 54.1 ± 11.4 years; 88 (69.3%) were male. Seventy patients (55.1%) exhibited a favorable response to TNT, while 57 patients (44.9%) demonstrated a poor response. Tumor characteristics, including diameter, distance from the anal verge, pre-TNT lymphocyte, pre-TNT hemoglobin, CA199, PLR, and HALP, exhibit correlations with TNT-induced tumor regression. Multivariate logistic regression analysis identified large tumor diameters (> 5.0 cm; p = 0.005, HR 2.958; 95% CI 1.382– 6.335) and low HALP (≤ 40; p = 0.002, HR 0.261; 95% CI 0.111– 0.612) as predictors of TNT-induced poor responses. Additionally, low levels of HALP were associated with an increased risk of recurrence in patients with LARC with TNT, but this was not statistically significant (p = 0.087, HR 2.008, 95% CI 0.906– 4.447).Conclusion: A large tumor diameter and low HALP predict poor tumor regression induced by the CAPOX-based TNT regimen in patients with LARC.Plain Language Summary: Recent studies have shown that total neoadjuvant therapy (TNT) is becoming a key treatment for some people with advanced rectal cancer. However, there’s still a lot we do not know about what affects how well patients respond to this treatment. The aim of this study was to see if certain nutritional and inflammatory measures, along with other clinic characteristics, can predict how well patients with advanced rectal cancer will respond to TNT. We looked back at medical records from 127 patients who received TNT between 2017 and 2021. We examined how certain pre-treatment factors were linked to patients’ responses to the therapy. Certain tumor characteristics and blood test results were connected to how well the tumors responded to treatment. Specifically, patients with larger tumors (over 5 cm in diameter) and lower levels of a specific blood marker called HALP were more likely to have a poor response to treatment. Although low HALP was also linked to a higher chance of the cancer coming back, this result was not strong enough to be certain about.Keywords: Rectal cancer, Total neoadjuvant therapy, HALP, Tumor regression
Published: 2024

28. Abnormal Functional Connectivity Intra- and Inter-Network in Resting-State Brain Networks of Patients with Toothache

Author: Zhu Y, Lai X, Wang M, Tang X, Wan T, Li B, Liu X, Wu J, He L, and He Y
Subjects: toothache, independent component analysis, resting-state networks, granger causality, Medicine (General), R5-920
Abstract: Yuping Zhu,1 Xunfu Lai,1 Mengting Wang,2 Xin Tang,1 Tianyi Wan,3 Bin Li,1 Xiaoming Liu,1 Jialin Wu,1 Lei He,1 Yulin He1 1Department of Radiology, The First Affiliated Hospital of Nanchang University, Nanchang, People’s Republic of China; 2Department of Radiology, Yichang Central People’s Hospital, Yichang, People’s Republic of China; 3Department of Radiology, Jiangxi Provincial People’s Hospital, Nanchang, People’s Republic of ChinaCorrespondence: Yulin He, Department of Radiology, The First Affiliated Hospital of Nanchang University, 17 Yongwaizheng Street, Nanchang, Jiangxi, 330006, People’s Republic of China, Tel +86 0791 8869 3802, Email ndyfy02171@ncu.edu.cnObjective: To separate the resting-state network of patients with dental pain using independent component analysis (ICA) and analyze abnormal changes in functional connectivity within as well as between the networks.Patients and Methods: Twenty-three patients with dental pain and 30 healthy controls participated in this study. We extracted the resting-state functional network components of both using ICA. Functional connectivity differences within 14 resting-state brain networks were analyzed at the voxel level. Directional interactions between networks were analyzed using Granger causality analysis. Subsequently, functional connectivity values and causal coefficients were assessed for correlations with clinical parameters.Results: Compared to healthy controls, we found enhanced functional connectivity in the left superior temporal gyrus of anterior protrusion network and the right Rolandic operculum of auditory network in patients with dental pain (p< 0.01 and cluster-level p< 0.05, Gaussian random field corrected). In contrast, functional connectivity of the right precuneus in the precuneus network was reduced, and were significantly as well as negatively correlated to those of the Visual Analogue Scale (r=− 4.93, p=0.017), Hamilton Anxiety Scale (r=− 0.46, p=0.027), and Hamilton Depression Scale (r=− 0.563, p< 0.01), using the Spearman correlation analysis. Regarding the causal relationship between resting-state brain networks, we found increased connectivity from the language network to the precuneus in patients with dental pain (p< 0.05, false discovery rate corrected). However, the increase in causal coefficients from the verbal network to the precuneus network was independent of clinical parameters.Conclusion: Patients with toothache exhibited abnormal functional changes in cognitive-emotion-related brain networks, such as the salience, auditory, and precuneus networks, thereby offering a new imaging basis for understanding central neural mechanisms in dental pain patients.Keywords: toothache, independent component analysis, resting-state networks, Granger causality
Published: 2024

29. Immediate Efficacy of Contralateral Acupuncture on SI3 Combined with Active Exercise for Acute Lumbar Sprains: Protocol for a Randomized Controlled Trial

Author: Tang X, Li Q, Huang G, Chen Z, Huang Y, Pei X, Zhao S, Liu Z, Guo T, and Liang F
Subjects: acute lumbar sprain, immediate efficacy, contralateral acupuncture, active exercise, randomized controlled trial, Medicine (General), R5-920
Abstract: Xin Tang,1,&ast; Qifu Li,1,&ast; Gaoyangzi Huang,1 Ziwen Chen,2 Ya Huang,1 Xianmei Pei,1 Siwen Zhao,1 Zili Liu,1 Taipin Guo,1 Fanrong Liang2 1School of Second Clinical Medicine/The Second Affiliated Hospital, Yunnan University of Chinese Medicine, Kunming, People’s Republic of China; 2College of Acupuncture and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Taipin Guo, School of Second Clinical Medicine/The Second Affiliated Hospital, Kunming, People’s Republic of China, Email gtphncs@126.com Fanrong Liang, College of Acupuncture and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, People’s Republic of China, Email acuresearch@126.comPurpose: Acute lumbar sprain (ALS) is a common clinical disease characterized by persistent intolerable low back pain and limitation of movement, and quick pain relief and restoration of mobility in a short time are the main needs of patients when they visit the clinic. This study aims to evaluate the immediate efficacy of contralateral acupuncture (CAT) on SI3 combined with active exercise in treating ALS.Methods and Analysis: This study is a randomized controlled trial which will recruit 118 eligible participants aged 18 to 55 years with ALS at the Second Affiliated Hospital of Yunnan University of Chinese Medicine between March 2024 and December 2026. Participants will be randomly assigned to the acupuncture group or the sham-acupuncture group in a 1:1 ratio. The acupuncture group will receive a 10-minute acupuncture treatment combined with active exercise, while the sham-acupuncture group will receive a 10-minute sham acupuncture treatment combined with active exercise. Randomization will use a computer-generated sequence with allocation concealed in opaque envelopes. The primary outcome will be the pain visual analogue scale (VAS) scores after 10 minutes of treatment. Secondary outcomes will include the pain VAS scores at other time points (2, 4, 6, and 8 minutes post-treatment), the lumbar range of motion (ROM) scores at various time points, blinded assessment, the treatment effect expectancy scale, and the rescue analgesia rate. The analysis will follow the intention-to-treat principle. The primary outcome will be analyzed using ANCOVA, and secondary outcomes with repeated measures ANOVA. The rescue analgesia rate will be assessed using either the χ2 test or Fisher’s exact test.Discussion: This study is the first randomized controlled trial to assess the immediate efficacy of CAT in combination with active exercise for ALS. This study will provide a simple, rapid, and effective treatment for the clinical management of ALS.Keywords: acute lumbar sprain, immediate efficacy, contralateral acupuncture, active exercise, randomized controlled trial
Published: 2024

30. Multi-Omics Integration Analysis Revealed the Seed Germination Mechanism of Pecan

Author: Xue, T., Qiu, S., Yang, C., Tang, X., Liu, J., and Yuan, Y.
Published: 2024
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31. Deep underground laboratory measurement of $^{13}$C($\alpha$,$n$)$^{16}$O in the Gamow windows of the $s$- and $i$-processes

Author: Gao, B., Jiao, T. Y., Li, Y. T., Chen, H., Lin, W. P., An, Z., Ru, L. H., Zhang, Z. C., Tang, X. D., Wang, X. Y., Zhang, N. T., Fang, X., Xie, D. H., Fan, Y. H., Ma, L., Zhang, X., Bai, F., Wang, P., Fan, Y. X., Liu, G., Huang, H. X., Wu, Q., Zhu, Y. B., Chai, J. L., Li, J. Q., Sun, L. T., Wang, S., Cai, J. W., Li, Y. Z., Su, J., Zhang, H., Li, Z. H., Li, Y. J., Li, E. T., Chen, C., Shen, Y. P., Lian, G., Guo, B., Li, X. Y., Zhang, L. Y., He, J. J., Sheng, Y. D., Chen, Y. J., Wang, L. H., Zhang, L., Cao, F. Q., Nan, W., Nan, W. K., Li, G. X., Song, N., Cui, B. Q., Chen, L. H., Ma, R. G., Yan, S. Q., Liao, J. H., Wang, Y. B., Zeng, S., Nan, D., Fan, Q. W., Qi, N. C., Sun, W. L., Guo, X. Y., Zhang, P., Chen, Y. H., Zhou, Y., Zhou, J. F., He, J. R., Shang, C. S., Li, M. C., Kubono, S., Liu, W. P., deBoer, R. J., Wiescher, M., and Pignatari, M.
Subjects: Nuclear Experiment
Abstract: The $^{13}$C($\alpha$,$n$)$^{16}$O reaction is the main neutron source for the slow-neutron-capture (s-) process in Asymptotic Giant Branch stars and for the intermediate (i-) process. Direct measurements at astrophysical energies in above-ground laboratories are hindered by the extremely small cross sections and vast cosmic-ray induced background. We performed the first consistent direct measurement in the range of $E_{\rm c.m.}=$0.24 MeV to 1.9 MeV using the accelerators at the China Jinping Underground Laboratory (CJPL) and Sichuan University. Our measurement covers almost the entire i-process Gamow window in which the large uncertainty of the previous experiments has been reduced from 60\% down to 15\%, eliminates the large systematic uncertainty in the extrapolation arising from the inconsistency of existing data sets, and provides a more reliable reaction rate for the studies of the s- and i-processes along with the first direct determination of the alpha strength for the near-threshold state.
Published: 2022
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32. The JCMT BISTRO Survey: Multi-wavelength polarimetry of bright regions in NGC 2071 in the far-infrared/submillimetre range, with POL-2 and HAWC+

Author: Fanciullo, L., Kemper, F., Pattle, K., Koch, P. M., Sadavoy, S., Coudé, S., Soam, A., Hoang, T., Onaka, T., Gouellec, V. J. M. Le, Arzoumanian, D., Berry, D., Eswaraiah, C., Chung, E. J., Furuya, R., Hull, C. L. H., Hwang, J., Johnstone, D., Kang, J. -h., Kim, K. H., Kirchschlager, F., Könyves, V., Kwon, J., Kwon, W., Lai, S. -P., Lee, C. W., Liu, T., Lyo, A. -R., Stephens, I., Tamura, M., Tang, X., Ward-Thompson, D., Whitworth, A., and Shinnaga, H.
Subjects: Astrophysics - Astrophysics of Galaxies
Abstract: Polarized dust emission is a key tracer in the study of interstellar medium and of star formation. The observed polarization, however, is a product of magnetic field structure, dust grain properties and grain alignment efficiency, as well as their variations in the line of sight, making it difficult to interpret polarization unambiguously. The comparison of polarimetry at multiple wavelengths is a possible way of mitigating this problem. We use data from HAWC+/SOFIA and from SCUBA-2/POL-2 (from the BISTRO survey) to analyse the NGC 2071 molecular cloud at 154, 214 and 850 $\mu$m. The polarization angle changes significantly with wavelength over part of NGC 2071, suggesting a change in magnetic field morphology on the line of sight as each wavelength best traces different dust populations. Other possible explanations are the existence of more than one polarization mechanism in the cloud or scattering from very large grains. The observed change of polarization fraction with wavelength, and the 214-to-154 $\mu$m polarization ratio in particular, are difficult to reproduce with current dust models under the assumption of uniform alignment efficiency. We also show that the standard procedure of using monochromatic intensity as a proxy for column density may produce spurious results at HAWC+ wavelengths. Using both long-wavelength (POL-2, 850 $\mu$m) and short-wavelength (HAWC+, $\lesssim 200\, \mu$m) polarimetry is key in obtaining these results. This study clearly shows the importance of multi-wavelength polarimetry at submillimeter bands to understand the dust properties of molecular clouds and the relationship between magnetic field and star formation., Comment: Main article: 18 pages, 11 figures. Online supplemental material: 2 pages, 3 figures
Published: 2022
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33. A comparative study of air pollution tolerance capabilities of four tree species in Xi’an city, China

Author: Zheng, J., Qu, X., Hou, R., Tang, X., Xu, Z., Huang, Z., Wang, Z., Zhang, W., Yang, C., and Li, T.
Published: 2024
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34. Development and Prospect of Arsenic Removal Technology for Containing Arsenic Copper Minerals

Author: Tang, X. W. and He, Y. H.
Published: 2023
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35. A Novel Nomogram to Predict Prognosis in Elderly Early-Stage Hepatocellular Carcinoma Patients After Ablation Therapy

Author: Tang X, Wang Q, Jin R, and Hu C
Subjects: hepatocellular carcinoma, elderly, radiofrequency ablation, ehcc, relapse, prognostic model, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract: Xiaomeng Tang,1– 4,&ast; Qi Wang,2– 4,&ast; Ronghua Jin,2– 4 Caixia Hu1 1Interventional Therapy Center for Oncology, Beijing You’an Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Beijing Institute of Infectious Diseases, Beijing, People’s Republic of China; 3National Center for Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, People’s Republic of China; 4Beijing Key Laboratory of Emerging Infectious Diseases, Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Caixia Hu, Interventional therapy center for oncology; Beijing You’an Hospital, Capital Medical University, 8 Xitoutiao, Youanmenwai Street, Fengtai District, Beijing, People’s Republic of China, Tel/Fax +86-13811395702, Email hucaixia1217@126.com Ronghua Jin, Beijing Ditan Hospital, Capital Medical University, 8 Jingshun East Street, Chaoyang District, Beijing, People’s Republic of China, Tel/Fax +86-13811611118, Email ronghuajin@ccmu.edu.cnPurpose: Hepatocellular carcinoma (HCC) is the predominant form of primary liver cancer. Early diagnosis is crucial for improving prognosis. Elderly HCC patients often have underlying liver diseases such as chronic hepatitis and cirrhosis, leading to impaired liver function and suboptimal liver reserve. Radiofrequency ablation (RFA) has rapidly become one of the most important methods for treating early-stage hepatocellular carcinoma (EHCC) due to its advantages, including minimal trauma, short operation time, less intraoperative bleeding, quick postoperative recovery, cost-effectiveness, and few postoperative-complications. However, the prognostic model for early recurrence after local ablation in elderly EHCC patients has not been widely evaluated. We have developed a prognostic model for the recurrence of local RFA in elderly EHCC patients. This is expected to provide a new early warning system for preventing early recurrence in elderly EHCC patients, prolonging patient’s life, and improving overall quality of life.Methods: In this study, we included 661 EHCC patients who underwent local ablation, dividing them into a Primary cohort and a Validation cohort in a 7:3 ratio. We characterized the cohorts and utilized the primary cohort to develop a prognostic nomogram model for recurrence after local ablation in elderly EHCC patients. Additionally, the validation cohort was used to assess the potential of the nomogram as a non-invasive biomarker for post-ablation recurrence in EHCC.Results: The user-friendly nomogram incorporates common clinical variables including gender, BCLC stage, tumor number, tumor size, red blood cell (RBC), gamma-glutamyl transferase (GGT), and prothrombin time activity (PTA). The nomogram constructed using the identified seven variables exhibits robust discriminatory capabilities, favorable predictive performance, and noteworthy clinical utility.Conclusion: We developed a user-friendly nomogram based on the BCLC stage classification, which may provide prognostic assessments for elderly EHCC patients at 1, 3, and 5 years post-RFA.Keywords: hepatocellular carcinoma, elderly, radiofrequency ablation, EHCC, relapse, prognostic model
Published: 2024

36. Gold Nanorod-Loaded Nano-Contrast Agent with Composite Shell-Core Structure for Ultrasonic/Photothermal Imaging-Guided Therapy in Ischemic Muscle Disorders

Author: Tang X, Liu Y, Zhao M, He L, Guo J, Wang T, Li W, and Zhao J
Subjects: ultrasonography, nanoscale contrast agent, nanotechnology, musculoskeletal ultrasound, photothermal imaging, microcirculatory perfusion, Medicine (General), R5-920
Abstract: Xiaoyi Tang,1,2,&ast; Yijia Liu,1,2,&ast; Mengxin Zhao,3,&ast; Lei He,3 Jiahao Guo,3 Tian Wang,3 Wei Li,3 Jiaqi Zhao1 1Department of Ultrasound, Shanghai Fourth People’s Hospital, School of Medicine, Tongji University, Shanghai, 200434, People’s Republic of China; 2Department of Ultrasound, the Second Affiliated Hospital of Naval Medical University (Shanghai Changzheng Hospital), Shanghai, 200003, People’s Republic of China; 3Department of Nanomedicine, Naval Medical University, Shanghai & School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, 200433, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Wei Li; Jiaqi Zhao, Email liwei@smmu.edu.cn; ultrasoundczzjq@163.comPurpose: This study aims to broaden the application of nano-contrast agents (NCAs) within the realm of the musculoskeletal system. It aims to introduce novel methods, strategies, and insights for the clinical management of ischemic muscle disorders, encompassing diagnosis, monitoring, evaluation, and therapeutic intervention.Methods: We developed a composite encapsulation technique employing O-carboxymethyl chitosan (OCMC) and liposome to encapsulate NCA-containing gold nanorods (GNRs) and perfluoropentane (PFP). This nanoscale contrast agent was thoroughly characterized for its basic physicochemical properties and performance. Its capabilities for in vivo and in vitro ultrasound imaging and photothermal imaging were authenticated, alongside a comprehensive biocompatibility assessment to ascertain its effects on microcirculatory perfusion in skeletal muscle using a murine model of hindlimb ischemia, and its potential to augment blood flow and facilitate recovery.Results: The engineered GNR@OCMC-liposome/PFP nanostructure exhibited an average size of 203.18± 1.49 nm, characterized by size uniformity, regular morphology, and a good biocompatibility profile. In vitro assessments revealed NCA’s potent photothermal response and its transformation into microbubbles (MBs) under near-infrared (NIR) irradiation, thereby enhancing ultrasonographic visibility. Animal studies demonstrated the nanostructure’s efficacy in photothermal imaging at ischemic loci in mouse hindlimbs, where NIR irradiation induced rapid temperature increases and significantly increased blood circulation.Conclusion: The dual-modal ultrasound/photothermal NCA, encapsulating GNR and PFP within a composite shell-core architecture, was synthesized successfully. It demonstrated exceptional stability, biocompatibility, and phase transition efficiency. Importantly, it facilitates the encapsulation of PFP, enabling both enhanced ultrasound imaging and photothermal imaging following NIR light exposure. This advancement provides a critical step towards the integrated diagnosis and treatment of ischemic muscle diseases, signifying a pivotal development in nanomedicine for musculoskeletal therapeutics.Keywords: ultrasonography, nanoscale contrast agent, nanotechnology, musculoskeletal ultrasound, photothermal imaging, microcirculatory perfusion
Published: 2024

37. Sex Differences in Personality Disorder and Childhood Maltreatment of Patients with Schizophrenia

Author: Wang X, Ni X, Wei Y, Xu L, Tang X, Liu H, Wang Z, Chen T, Wang J, Zhang Q, and Zhang T
Subjects: personality disorder, psychosis, abuse, neglect, schizophrenia, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429
Abstract: XiaoLiang Wang,1,&ast; XiaoDong Ni,1,&ast; YanYan Wei,1 LiHua Xu,1 XiaoChen Tang,1 HaiChun Liu,2 ZiXuan Wang,3 Tao Chen,4,5 JiJun Wang,1 Qing Zhang,1 TianHong Zhang1 1Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Engineering Research Center of Intelligent Psychological Evaluation and Intervention, Shanghai Key Laboratory of Psychotic Disorders, Shanghai, People’s Republic of China; 2Department of Automation, Shanghai Jiao Tong University, Shanghai, People’s Republic of China; 3Department of Psychology, Shanghai Xinlianxin Psychological Counseling Center, Shanghai, People’s Republic of China; 4Big Data Research Lab, University of Waterloo, Waterloo, Ontario, Canada; 5Labor and Worklife Program, Harvard University, Cambridge, MA, USA&ast;These authors contributed equally to this workCorrespondence: TianHong Zhang; Qing Zhang, Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, 600 Wanping Nan Road, Shanghai, 200030, People’s Republic of China, Tel +86-21-34773065, Fax +86-21-64387986, Email zhang_tianhong@126.com; qing.zhang@smhc.org.cnIntroduction: Despite numerous studies investigating personality disorder (PD) and childhood maltreatment (CM) characteristics in individuals with schizophrenia (SZ), there remains a scarcity of research focusing on sex differences in PD and CM within large samples of SZ patients.Methods: A total of 592 participants (257 males, 335 females) were consecutively sampled from patients diagnosed with SZ at the psychiatric and psycho-counseling clinics at Shanghai Mental Health Center. PDs were assessed using a self-reported personality diagnostic questionnaire and a structured clinical interview, while CMs were evaluated using the Chinese version of the Child Trauma Questionnaire Short Form.Results: Male patients exhibited a prominent self-reported trait of antisocial PD (t=1.972, p=0.049), while female patients demonstrated a notable emphasis on histrionic PD traits (t=− 2.057, p=0.040). Structured interviews for PD diagnoses further indicated a higher comorbidity of schizotypal (χ2=4.805, p=0.028) and schizoid (χ2=6.957, p=0.008) PDs among male patients compared to female patients. Additionally, male patients reported a higher degree (t=2.957, p=0.003) and proportion (χ2=5.277, p=0.022) of experiences of physical abuse in their self-reported CM. Logistic regression analyses highlight distinct factors: higher antisocial PD traits and physical abuse are associated with male patients, while histrionic PD traits and emotional abuse are associated with female patients.Discussion: These findings underscore the importance of recognizing and addressing sex-specific manifestations of personality pathology and the nuanced impact of CM in the clinical management of individuals with SZ. The study advocates for tailored interventions that consider the distinct needs associated with sex differences in both personality traits and CM experiences among SZ patients.Keywords: personality disorder, psychosis, abuse, neglect, schizophrenia
Published: 2024

38. Promising Intestinal Microbiota Associated with Clinical Characteristics of COPD Through Integrated Bioinformatics Analysis

Author: Lai T, Luo C, Yuan Y, Fang J, Wang Y, Tang X, Ouyang L, Lin K, Wu B, Yao W, and Huang R
Subjects: chronic obstructive pulmonary disease, intestinal microbiota, 16s rdna sequencing, lachnospira, gut-lung axis, Diseases of the respiratory system, RC705-779
Abstract: Tianwen Lai,1,&ast; Chaole Luo,1,&ast; Yalian Yuan,2,&ast; Jia Fang,1,&ast; Yun Wang,1 Xiantong Tang,1 Lihuan Ouyang,1 Keyan Lin,1 Bin Wu,2 Weimin Yao,1 Ruina Huang1 1Department of Respiratory and Critical Care Medicine, the First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, 523121, People’s Republic of China; 2Respiratory Diseases Research Institute, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Ruina Huang; Weimin Yao, Email wolidedd@163.com; yaoweimin@gdmu.edu.cnIntroduction: Chronic obstructive pulmonary disease (COPD), an incurable chronic respiratory disease, has become a major public health problem. The relationship between the composition of intestinal microbiota and the important clinical factors affecting COPD remains unclear. This study aimed to identify specific intestinal microbiota with high clinical diagnostic value for COPD.Methods: The fecal microbiota of patients with COPD and healthy individuals were analyzed by 16S rDNA sequencing. Random forest classification was performed to analyze the different intestinal microbiota. Spearman correlation was conducted to analyze the correlation between different intestinal microbiota and clinical characteristics. A microbiota-disease network diagram was constructed using the gut MDisorder database to identify the possible pathogenesis of intestinal microorganisms affecting COPD, screen for potential treatment, and guide future research.Results: No significant difference in biodiversity was shown between the two groups but significant differences in microbial community structure. Fifteen genera of bacteria with large abundance differences were identified, including Bacteroides, Prevotella, Lachnospira, and Parabacteroides. Among them, the relative abundance of Lachnospira and Coprococcus was negatively related to the smoking index and positively related to lung function results. By contrast, the relative abundance of Parabacteroides was positively correlated with the smoking index and negatively correlated with lung function findings. Random forest classification showed that Lachnospira was the genus most capable of distinguishing between patients with COPD and healthy individuals suggesting it may be a potential biomarker of COPD. A Lachnospira disease network diagram suggested that Lachnospira decreased in some diseases, such as asthma, diabetes mellitus, and coronavirus disease 2019 (COVID-19), and increased in other diseases, such as irritable bowel syndrome, hypertension, and bovine lichen.Conclusion: The dominant intestinal microbiota with significant differences is related to the clinical characteristics of COPD, and the Lachnospira has the potential value to identify COPD.Keywords: chronic obstructive pulmonary disease, intestinal microbiota, 16S rDNA sequencing, Lachnospira, gut-lung axis
Published: 2024

39. Correlation of Peripheral Blood Inflammatory Indicators to Prognosis After Intravenous Thrombolysis in Acute Ischemic Stroke: A Retrospective Study

Author: Zhang T, Fu S, Cao X, Xia Y, Hu M, Feng Q, Cong Y, Zhu Y, Tang X, and Wu M
Subjects: modified rankin scale, reperfusion therapy, inflammatory reaction, cerebral vascular disease, clinical prognosis., Medicine (General), R5-920
Abstract: Tianrui Zhang,1,&ast; Sha Fu,1,&ast; Xiaofeng Cao,2 Yangjingyi Xia,1 Manyan Hu,1 Qinghua Feng,1 Yujun Cong,1 Yuan Zhu,1 Xiaogang Tang,1 Minghua Wu1 1Department of Neurology, Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing, 210029, People’s Republic of China; 2Department of Neurology, Jiangyan Hospital of Chinese Medicine, Taizhou, Jiangsu, 225500, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Minghua Wu; Xiaogang Tang, Department of Neurology, Affiliated Hospital of Nanjing University of Chinese Medicine, 155 Hanzhong Road, Nanjing, 210029, People’s Republic of China, Tel +8613951786719, Email yfy0069@njucm.edu.cn; zhongyiTXG@163.comPurpose: According to many previous studies, neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR) and hypersensitive C-reactive protein (CRP) are commonly used as important indicators to assess the prognosis of intravenous thrombolysis in AIS patients. Based on this, we used two novel biomarkers C-NLR (CRP/neutrophil-to-lymphocyte ratio) and C-LMR (CRP×lymphocyte-to-monocyte ratio) to investigate their correlation with 90-day outcomes in AIS patients after intravenous thrombolysis.Patients and Methods: A total of 204 AIS patients who received intravenous thrombolysis at the Stroke Center of Jiangsu Province Hospital of Chinese Medicine from January 2021 to December 2022 were retrospectively included. All patients were followed up 90 days after thrombolysis to assess their prognosis. Patients with a modified Rankin scale score (mRS) of 3– 6 were included in the unfavorable outcome group, and those with a score of 0– 2 were included in the favorable outcome group. Logistic regression analysis, receiver operating characteristic (ROC) curve, and Kaplan–Meier survival curve were used to investigate the association between C-NLR, C-LMR, and 90-day prognosis in AIS patients treated with early intravenous thrombolysis.Results: C-NLR (OR=1.586, 95% CI=1.098~2.291, P=0.014) and C-LMR (OR=1.099, 95% CI=1.025~1.179, P=0.008) were independent risk factors for 90-day prognosis of AIS patients treated with early intravenous thrombolysis. The higher C-NLR and C-LMR were associated with unfavorable prognosis.Conclusion: C-NLR and C-LMR can be used as biomarkers to predict prognosis of AIS patients treated with early intravenous thrombolysis.Keywords: modified rankin scale, reperfusion therapy, inflammatory reaction, cerebral vascular disease, clinical prognosis
Published: 2024

40. Exploring Symptom Clusters in Chinese Patients with Diabetic Kidney Disease: A Network Analysis

Author: Duan DF, Liu M, Ma DY, Yan LJ, Huang YY, Chen Y, Jiang W, Tang X, Xiong AQ, and Shi YY
Subjects: diabetic kidney disease, network analysis, symptom cluster, symptom management., Medicine (General), R5-920
Abstract: Di-Fei Duan,1,2,&ast; Min Liu,1,2,&ast; Deng-Yan Ma,1,2 Lin-Jia Yan,3 Yue-Yang Huang,1,2 Yi Chen,1,2 Wei Jiang,1,2 Xi Tang,2 An-Qi Xiong,4,5 Yun-Ying Shi2 1West China School of Nursing, West China Hospital, Sichuan University, Chengdu, Sichuan Province, People’s Republic of China; 2Department of Nephrology, Kidney Research Institute, West China Hospital, Sichuan University, Chengdu, Sichuan Province, People’s Republic of China; 3The Nethersole School of Nursing Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, People’s Republic of China; 4Department of Nursing, West China Second University Hospital, Sichuan University, Chengdu, Sichuan Province, People’s Republic of China; 5Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, Sichuan Province, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Deng-Yan Ma, Email mdy5104@163.comPurpose: The research on symptom management in patients with diabetic kidney disease (DKD) has shifted from separate symptoms to symptom clusters and networks recently. This study aimed to evaluate the unpleasant symptoms of DKD patients, and to investigate how these symptom clusters could affect patients.Methods: 408 DKD patients were recruited in this cross-sectional study. The symptoms of DKD patients were measured using the modified Dialysis Symptom Index. Network analysis was employed to evaluate the symptom network and the characteristics of individual nodes, while factor analysis was utilized to identify symptom clusters.Results: Blurred vision was the most prevalent symptom among DKD patients. The symptoms identified as the most distressing, severe, and frequent were light headache or dizziness, arteriovenous fistula/catheterization pain, and diarrhea, respectively. Five symptom clusters were obtained from factor analysis, and the most central symptom cluster in the entire symptom network was sexual dysfunction.Conclusion: This study identified five symptom clusters in Chinese DKD patients, with sexual dysfunction emerging as the most central cluster. These findings carry significant clinical implications, underscoring the necessity of assessing symptom clusters and their associations to enhance symptom management in DKD patients. Further research is essential to elucidate the underlying mechanisms of symptoms and to clarify the associations among symptoms in DKD patients across different disease trajectories or treatment modalities.Keywords: diabetic kidney disease, network analysis, symptom cluster, symptom management
Published: 2024

41. Interstellar Nitrogen Isotope Ratios: New NH3 Data from the Galactic Center out to the Perseus Arm

Author: Chen, J. L., Zhang, J. S., Henkel, C., Yan, Y. T., Yu, H. Z., Qiu, J. J., Tang, X. D., Wang, J., Liu, W., Wang, Y. X., Zheng, Y. H., Zhao, J. Y., and Zou, Y. P.
Subjects: Astrophysics - Astrophysics of Galaxies
Abstract: Our aim is to measure the interstellar 14N/15N ratio across the Galaxy, to establish a standard data set on interstellar ammonia isotope ratios, and to provide new constraints on the Galactic chemical evolution. The (J, K ) = (1, 1), (2, 2), and (3, 3) lines of 14NH3 and 15NH3 were observed with the Shanghai Tianma 65 m radio telescope (TMRT) and the Effelsberg 100 m telescope toward a large sample of 210 sources. One hundred fourty-one of these sources were detected by the TMRT in 14NH3. Eight of them were also detected in 15NH3. For 10 of the 36 sources with strong NH3 emission, the Effelsberg 100 m telescope successfully detected their 15NH3(1, 1) lines, including 3 sources (G081.7522, W51D, and Orion-KL) with detections by the TMRT telescope. Thus, a total of 15 sources are detected in both the 14NH3 and 15NH3 lines. Line and physical parameters for these 15 sources are derived, including optical depths, rotation and kinetic temperatures, and total column densities. 14N/15N isotope ratios were determined from the 14NH3/15NH3 abundance ratios. The isotope ratios obtained from both telescopes agree for a given source within the uncertainties, and no dependence on heliocentric distance and kinetic temperature is seen. 14N/15N ratios tend to increase with galactocentric distance, confirming a radial nitrogen isotope gradient. This is consistent with results from recent Galactic chemical model calculations, including the impact of superasymptotic giant branch stars and novae.
Published: 2022
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42. Optimal Repair/Access MDS Array Codes with Multiple Repair Degrees

Author: Liu, Y., Li, J., and Tang, X. H.
Subjects: Computer Science - Information Theory
Abstract: In the literature, most of the known high-rate $(n,k)$ MDS array codes with the optimal repair property only support a single repair degree (i.e., the number of helper nodes contacted during a repair process) $d$, where $k\le d\le n-1$. However, in practical storage systems, the number of available nodes changes frequently. Thus, it is preferred to construct $(n,k)$ MDS array codes with multiple repair degrees and the optimal repair property for all nodes. To the best of our knowledge, only two MDS array codes have such properties in the literature, which were proposed by Ye and Barg (IEEE Trans. Inform. Theory, 63(10), 2001-2014, 2017). However, their sub-packetization levels are relatively large. In this paper, we present a generic construction method that can convert some MDS array codes with a single repair degree into the ones with multiple repair degrees and optimal repair property for a set of nodes, while the repair efficiency/degrees of the remaining nodes can be kept. As an application of the generic construction method, an explicit construction of high-rate MDS array code with multiple repair degrees and the optimal access property for all nodes is obtained over a small finite field. Especially, the sub-packetization level is much smaller than that of the two codes proposed by Ye and Barg concerning the same parameters $n$ and $k$., Comment: 27 pages
Published: 2022

43. Opportunities and Challenges for Inhalable Nanomedicine Formulations in Respiratory Diseases: A Review

Author: Feng X, Shi Y, Zhang Y, Lei F, Ren R, and Tang X
Subjects: nanoparticles, respiratory system, lungs, nanomaterials, nanotechnology, Medicine (General), R5-920
Abstract: Xujun Feng, Yuan Shi, Ye Zhang, Fei Lei, Rong Ren, Xiangdong Tang Department of Respiratory and Critical Care Medicine, Sleep Medicine Center, Mental Health Center, West China Hospital, Sichuan University, Chengdu, People’s Republic of ChinaCorrespondence: Rong Ren; Xiangdong Tang, Department of Respiratory and Critical Care Medicine, Sleep Medicine Center, Mental Health Center, West China Hospital, Sichuan University, Dian Xin Nan Jie 28&num;, Chengdu, 610041, People’s Republic of China, Tel +86-28-85422733, Email 498880651@qq.com; 2372564613@qq.comAbstract: Lungs experience frequent interactions with the external environment and have an abundant supply of blood; therefore, they are susceptible to invasion by pathogenic microorganisms and tumor cells. However, the limited pharmacokinetics of conventional drugs in the lungs poses a clinical challenge. The emergence of different nano-formulations has been facilitated by advancements in nanotechnology. Inhaled nanomedicines exhibit better targeting and prolonged therapeutic effects. Although nano-formulations have great potential, they still present several unknown risks. Herein, we review the (1) physiological anatomy of the lungs and their biological barriers, (2) pharmacokinetics and toxicology of nanomaterial formulations in the lungs; (3) current nanomaterials that can be applied to the respiratory system and related design strategies, and (4) current applications of inhaled nanomaterials in treating respiratory disorders, vaccine design, and imaging detection based on the characteristics of different nanomaterials. Finally, (5) we analyze and summarize the challenges and prospects of nanomaterials for respiratory disease applications. We believe that nanomaterials, particularly inhaled nano-formulations, have excellent prospects for application in respiratory diseases. However, we emphasize that the simultaneous toxic side effects of biological nanomaterials must be considered during the application of these emerging medicines. This study aims to offer comprehensive guidelines and valuable insights for conducting research on nanomaterials in the domain of the respiratory system. Keywords: nanoparticles, respiratory system, lungs, nanomaterials, nanotechnology
Published: 2024

44. Network Pharmacology, Molecular Docking, and Experimental Verification to Reveal the Mitophagy-Associated Mechanism of Tangshen Formula in the Treatment of Diabetic Nephropathy

Author: Chen Y, Wang X, Min J, Zheng J, Tang X, Zhu X, Yu D, and Jin D
Subjects: tangshen formula, diabetes nephropathy, network pharmacology, mitophagy, pink1/parkin pathway, Specialties of internal medicine, RC581-951
Abstract: Yinfeng Chen,&ast; Xiaying Wang,&ast; Jie Min, Jie Zheng, Xuanli Tang, Xiaoling Zhu, Dongrong Yu, De Jin Department of Nephrology, Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, 310007, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Dongrong Yu; De Jin, Department of Nephrology, Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, 310007, People’s Republic of China, Email yudr68@163.com; 826901274@qq.comPurpose: This study investigated the mechanism of TSF in treating DN through network pharmacology, molecular docking, and experimental validation.Methods: To identify critical active ingredients, targets, and DN genes in TSF, multiple databases were utilized for screening purposes. The drug-compound-target network was constructed using Cytoscape 3.9.1 software for network topological analysis. The protein interaction relationship was analyzed using the String database platform. Metascape database conducted enrichment analysis on the key targets using Gene Ontology and the Kyoto Encyclopedia of Genes and Genomes. The renoprotective effect was evaluated using a mouse model of diabetic nephropathy (db/db mice) that occurred spontaneously. Validation of the associated targets and pathways was performed using Western Blot (WB), Polymerase Chain Reaction (PCR), and Immunohistochemical methods (IHC).Results: The network analysis showed that the TSF pathway network targeted 24 important targets and 149 significant pathways. TSF might have an impact by focusing on essential objectives such as TP53, PTEN, AKT1, BCL2, BCL2L1, PINK-1, PARKIN, LC3B, and NFE2L2, along with various growth-inducing routes. Our findings demonstrated that TSF effectively repaired the structure of mitochondria in db/db mice. TSF greatly enhanced the mRNA levels of PINK-1. WB and IHC findings indicated that TSF had a notable impact on activating the PINK-1/PARKIN signaling pathway in db/db mice, significantly increasing LC3 and NRF2 expression.Conclusion: Our results indicate that TSF effectively addresses DN by activating the PINK-1/PARKIN signaling pathway and enhancing Mitochondrion structure in experimental diabetic nephropathy.Keywords: tangshen formula, diabetes nephropathy, network pharmacology, mitophagy, PINK1/Parkin pathway
Published: 2024

45. Controlled siRNA Release of Nanopolyplex for Effective Targeted Anticancer Therapy in Animal Model

Author: Jia J, Yang J, Qian L, Zhou B, Tang X, Liu S, Wu L, Chen J, and Kuang Y
Subjects: nir-controlled sirna release, nanopolyplex, ucnps, anti-tumor therapy, Medicine (General), R5-920
Abstract: Jingchao Jia,1,2,&ast; Jing Yang,3,&ast; Leimin Qian,2 Biao Zhou,2 Xiaodong Tang,2 Shuanghai Liu,2 Li Wu,4 Jifeng Chen,5 Yuting Kuang1 1Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China; 2Department of General Surgery, Jiangyin Hospital Affiliated to Nantong University, Wuxi, People’s Republic of China; 3Jiangnan University Medical Center, Wuxi, People’s Republic of China; 4Department of Pharmaceutics, People’s Hospital of Shanggao, Yichun, People’s Republic of China; 5The Guangzhou Key Laboratory of Molecular and Functional Imaging for Clinical Translation, Jinan University, Guangzhou, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Yuting Kuang, Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China, Email yuting_kuang@163.com Jifeng Chen, The Guangzhou Key Laboratory of Molecular and Functional Imaging for Clinical Translation, Jinan University, Guangzhou, People’s Republic of China, Email chenjifeng-1987@163.comIntroduction: Spatiotemporally controlled release of siRNA for anti-tumor therapy poses significant challenges. Near-infrared (NIR) light, known for its exceptional tissue penetration and minimal tissue invasiveness, holds promise as a viable exogenous stimulus for inducing controlled siRNA release in vivo. However, the majority of light-responsive chemical bonds exhibit absorption wavelengths in the ultraviolet (UV) or short-wavelength visible light range.Methods: To achieve NIR-controlled siRNA release, the study synthesized a UV-sensitive triblock copolymer cRGD-poly(ethylene glycol)-b-poly(aspartic acid ester-5-(2’-(dimethylamino)ethoxy)-2-nitrobenzyl alcohol)-b-polyphenylalanine, abbreviated as cRGD-PEG-PAsp(EDONB)-PPHE. This copolymer is composed of a cRGD-capped PEG block (cRGD-PEG), a poly(aspartate) block modified with cationic moieties through UV-cleavable 2-nitrobenzyl ester bonds [PAsp(EDONB)], and a hydrophobic polyphenylalanine block (PPHE). The cationic amphiphilic polymer cRGD-PEG-PAsp(EDONB)-PPHE can assemble with hydrophobic upconversion nanoparticles (UCNPs) to form a cationic micelle designated as T-UCNP, which subsequently complexes with siRNA to create the final nanopolyplex T-si/UCNP. siRNA-PLK1 was employed to prepare T-PLK1/UCNP nanopolyplex for anti-tumor therapy.Results: T-PLK1/UCNP not only exhibited outstanding tumor cell targeting through cRGD modification but also achieved 980 nm NIR-controlled PLK1 gene silencing. This was achieved by utilizing the encapsulated UCNPs to convert NIR into UV light, facilitating the cleavage of 2-nitrobenzyl ester bonds. As a result, there was a significant suppression of tumor growth.Conclusion: The UCNPs-encapsulated nanopolyplex T-si/UCNP, capable of co-delivering siRNA and UCNPs, enables precise NIR-controlled release of siRNA at the tumor site for cancer RNAi therapy. This nanopolyplex can enhance the controllability and safety of RNAi therapy for tumors, and it also holds the potential to serve as a platform for achieving controlled release and activation of other drugs, such as mRNA and DNA.Keywords: NIR-controlled siRNA release, nanopolyplex, UCNPs, anti-tumor therapy
Published: 2024

46. Application of Multidimensional Quality Management Tools in the Management of Medical Adverse Events

Author: Yuan B, Song S, Tang X, and Ma Z
Subjects: multidimensional quality management tools, adverse events, management system, patient safety, Public aspects of medicine, RA1-1270
Abstract: Bei Yuan, Shibei Song, Xiao Tang, Zhanqiang Ma Medical Department, The Second People’s Hospital of Guizhou Province (Guizhou Province Mental Health Center), Guizhou, Guiyang, 550001, People’s Republic of ChinaCorrespondence: Zhanqiang Ma, Medical Department, The Second People’s Hospital of Guizhou Province (Guizhou Province Mental Health Center), Guizhou, Guiyang, 550001, People’s Republic of China, Tel +86-13017432067, Email 13017432067@163.comPurpose: This study aims to investigate the impact of multidimensional quality management tools in establishing a medical adverse event management system, with the aim of continuously improving medical quality and safety while ensuring patient well-being.Methods: This study introduces risk management theories, such as the “Gray Rhino Theory”, and employs quality management tools like the Plan-Do-Check-Act (PDCA) cycle, Quality Control Circle (QCC), and Root Cause Analysis (RCA), to provide relevant quality management education and training to employees. This approach facilitates the establishment of a medical adverse event management system that encourages reporting and fosters a blame-free reporting culture, while simultaneously implementing quality management across the entire process. The regular utilization of the QCC facilitates ongoing quality improvement. Furthermore, for sentinel events and patient harm incidents with educational values, the study employs the Incident Decision Tree (IDT) to determine appropriate actions. Additionally, the hospital initiates RCA for system-wide improvements, focusing on areas such as management, institutional processes, and environmental aspects. Moreover, an internal medical quality improvement case competition is organized, with outstanding cases being selected to participate in the multidimensional quality management competition organized by the National Quality Management Alliance.Results: The study reveals a significant improvement in employees’ awareness of adverse events, the percentage of employees reporting adverse events increased significantly from 39.15% in 2019 to 49.77% in 2022, P=0.002. Furthermore, the adverse event reporting rate has risen significantly from 2.78% (2019) to 5.96% (2022), P=0.002. Additionally, each department has been able to utilize QCC or RCA tools for quality improvement, thereby further reinforcing the development of a patient safety culture.Conclusion: Multidimensional quality management tools play a crucial role in establishing a hospital’s adverse event management system, promoting continuous improvement in medical quality, ensuring patient safety, and effectively implementing a culture of patient safety.Keywords: multidimensional quality management tools, adverse events, management system, patient safety
Published: 2024

47. Development of a low-background neutron detector array

Author: Li, Y. T., Lin, W. P., Gao, B., Chen, H., Huang, H., Huang, Y., Jiao, T. Y., Li, K. A., Tang, X. D., Wang, X. Y., Fang, X., Huang, H. X., Ren, J., Ru, L. H., Ruan, X. C., Zhang, N. T., and Zhang, Z. C.
Subjects: Physics - Instrumentation and Detectors, Nuclear Experiment
Abstract: A low-background neutron detector array was developed to measure the cross section of the $^{13}$C($\alpha$,n)$^{16}$O reaction, which is the neutron source for the $s$-process in AGB stars, in the Gamow window ($E_{c.m.}$ = 190 $\pm$ 40 keV) at the China Jinping Underground Laboratory (CJPL). The detector array consists of 24 $^{3}$He proportional counters embedded in a polyethylene cube. Due to the deep underground location and a borated polyethylene shield around the detector array, a low background of 4.5(2)/hour was achieved. The $^{51}$V(p, n)$^{51}$Cr reaction was used to determine the neutron detection efficiency of the array for neutrons with energy $E_n$ $<$ 1 MeV. Geant4 simulations, which were shown to well reproduce experimental results, were used to extrapolate the detection efficiency to higher energies for neutrons emitted in the $^{13}$C($\alpha$,n) $^{16}$O reaction. The theoretical angular distributions of the $^{13}$C($\alpha$,n)$^{16}$O reaction were shown to be important in estimating the uncertainties of the detection efficiency.
Published: 2021

48. Observations of multiple NH$_3$ transitions in W33

Author: Tursun, K., Henkel, C., Esimbek, J., Tang, X. D., Wilson, T. L., Malawi, A., Alkhuja, E., Wyrowski, F., Mauersberger, R., Immer, K., Asiri, H., Zhou, J. J., and Wu, G.
Subjects: Astrophysics - Astrophysics of Galaxies
Abstract: At a distance of 2.4kpc, W33 is an outstanding massive and luminous 10pc sized star forming complex containing quiescent infrared dark clouds as well as highly active infrared bright cloud cores heated by young massive stars. We report measurements of ammonia (NH$_3$) inversion lines in the frequency range 18--26GHz, obtained with the 40" resolution of the 100 m Effelsberg telescope. We have detected the ($J$, $K$)=(1,1), (2,2), (3,3), (4,4), (5,5), (6,6), (2,1) and (3,2) transitions. There is a maser line in the (3,3) transition towards W33 Main. Brightness temperature and line shape indicate no significant variation during the last $\sim$36yr. We have determined kinetic temperatures, column densities and other physical properties of NH$_3$ and the molecular clouds in W33. For the total-NH$_3$ column density, we find for 40"(0.5pc) sized regions 6.0($\pm$2.1)$\times$10$^{14}$, 3.5($\pm$0.1)$\times$10$^{15}$, 3.4($\pm$0.2)$\times$10$^{15}$, 3.1($\pm$0.2)$\times$10$^{15}$, 2.8($\pm$0.2)$\times$10$^{15}$ and 2.0($\pm$0.2)$\times$10$^{15}$cm$^{-2}$ at the peak positions of W33 Main, W33 A, W33 B, W33 Main1, W33 A1 and W33 B1, respectively. W33 Main has a total-NH$_3$ fractional abundance of 1.3($\pm$0.1)$\times$10$^{-9}$ at the peak position. High values of 1.4($\pm$0.3)$\times$10$^{-8}$, 1.6($\pm$0.3)$\times$10$^{-8}$, 3.4($\pm$0.5)$\times$10$^{-8}$, 1.6($\pm$0.5)$\times$10$^{-8}$ and 4.0($\pm$1.2)$\times$10$^{-8}$ are obtained at the central positions of W33 A, W33 B, W33 Main1, W33 A1, and W33 B1. From this, we confirm the already previously proposed different evolutionary stages of the six W33 clumps and find that there is no hot core in the region approaching the extreme conditions encountered in W51-IRS2 or Sgr B2. The ortho-to-para-NH$_3$ abundance ratios suggest that ammonia should have been formed in the gas phase or on dust grain mantles at kinetic temperatures of $\gtrsim$20K., Comment: 30 pages, 21 figures, accepted by A&A
Published: 2021
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49. The $^{59}$Fe(n, {\gamma})$^{60}$Fe Cross Section from the Surrogate Ratio Method and Its Effect on the $^{60}$Fe Nucleosynthesis

Author: Yan, S. Q., Li, X. Y., Nishio, K., Lugaro, M., Li, Z. H., Makii, H., Pignatari, M., Wang, Y. B., Orlandi, R., Hirose, K., Tsukada, K., Mohr, P., Li, G. S., Wang, J. G., Gao, B. S., Han, Y. L., Guo, B., Li, Y. J., Shen, Y. P., Sato, T. K., Ito, Y., Suzaki, F., Su, J., Yang, Y. Y., Wang, J. S., Ma, J. B., Ma, P., Bai, Z., Xu, S. W., Ren, J., Fan, Q. W., Zeng, S., Han, Z. Y., Nan, W., Nan, W. K., Chen, C., Lian, G., Hu, Q., Duan, F. F., Jin, S. Y., Tang, X. D., and Liu, W. P.
Subjects: Astrophysics - Astrophysics of Galaxies
Abstract: The long-lived $^{60}$Fe (with a half-life of 2.62 Myr) is a crucial diagnostic of active nucleosynthesis in the Milky Way galaxy and in supernovae near the solar system. The neutron-capture reaction $^{59}$Fe(n,$\gamma$)$^{60}$Fe on $^{59}$Fe (half-life = 44.5 days) is the key reaction for the production of $^{60}$Fe in massive stars. This reaction cross section has been previously constrained by the Coulomb dissociation experiment, which offered partial constraint on the $E$1 $\gamma$-ray strength function but a negligible constraint on the $M$1 and $E$2 components. In this work, for the first time, we use the surrogate ratio method to experimentally determine the $^{59}$Fe(n,$\gamma$)$^{60}$Fe cross sections in which all the components are included. We derived a Maxwellian-averaged cross section of 27.5 $\pm$ 3.5 mb at $kT$= 30 keV and 13.4 $\pm$ 1.7 mb at $kT$= 90 keV, roughly 10 - 20% higher than previous estimates. We analyzed the impact of our new reaction rates in nucleosynthesis models of massive stars and found that uncertainties in the production of $^{60}$Fe from the $^{59}$Fe(n,$\gamma$)$^{60}$Fe rate are at most of 25%. We conclude that stellar physics uncertainties now play a major role in the accurate evaluation of the stellar production of $^{60}$Fe., Comment: 9 pages with 6 figures
Published: 2021
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50. Effectiveness of cooling interventions on heat-stressed dairy cows based on a mechanistic thermoregulatory model

Author: Zhou, M., Tang, X., Xiong, B., Koerkamp, P.W.G. Groot, and Aarnink, A.J.A.
Published: 2024
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