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155 results on '"Tang, Wei-jun"'

1. EGb761 improves the cognitive function of elderly db/db−/− diabetic mice by regulating the beclin-1 and NF-κB signaling pathways

Author

Guan, Zhu-Fei, Zhang, Xiao-Ming, Tao, Ying-Hong, Zhang, Yu, Huang, Yan-Yan, Chen, Gang, Tang, Wei-Jun, Ji, Gang, Guo, Qi-Lin, Liu, Ming, Zhang, Qian, Wang, Na-Na, Yu, Zhong-Yu, Hao-Yang, Wu, Guo-Feng, Tang, Zhou-Ping, Du, Zun-Guo, Shang, Xi-Liang, Liu, Ying-Chao, Mei, Guang-Hai, Guo, Jing-Chun, and Zhou, Hou-Guang

Published
2018
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4. Comparison of electroacupuncture and moxibustion on brain-gut function in patients with diarrhea-predominant irritable bowel syndrome: A randomized controlled trial

Author

Zhao, Ji-meng / 赵继梦, Lu, Jin-hua / 卢金花, Yin, Xiao-jun / 尹小君, Chen, Xing-kui / 陈兴奎, Chen, Yue-hua / 陈跃华, Tang, Wei-jun / 汤伟军, Jin, Xiao-ming / 金小明, Wu, Lu-yi / 吴璐一, Bao, Chun-hui / 包春辉, Wu, Huan-gan / 吴焕淦, and Shi, Yin / 施 茵

Published
2015
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16. Abstract TP465: Autonomic Dysfunction and Potentially Related Brain Regions in Cerebral Small Vessel Disease

Author

Tang Wei-jun, Zhang Miaoyi, Ding Ding, Jianhui Fu, and Yu Huan

Subjects
Advanced and Specialized Nursing, medicine.medical_specialty, business.industry, Disease, Hypoxia (medical), Autonomic nervous system, Blood pressure, Internal medicine, Heart rate, medicine, Cardiology, Neurology (clinical), Small vessel, medicine.symptom, Cardiology and Cardiovascular Medicine, business
Abstract

Objects: To observe the fluctuations of nocturnal oxygen saturation, heart rate and blood pressure and whether there are autonomic dysfunction related brain regions in cerebral small vessel disease (CSVD). Methods: Consecutive patients with arteriosclerotic CSVD and community-dwelling elders without CSVD between 50 and 80 years old were enrolled. The parameters of oxygen saturation fluctuations and heart rate variability(HRV) were synchronously collected by polysomnography(PSG). 24-hour ambulatory blood pressure monitoring were also performed to assess the circadian rhythm and blood pressure variability(BPV). The differences in the above parameters were analyzed using appropriate statistical methods. Additionally, the voxel based morphometry (VBM) analysis was used to determine whether there were autonomic dysfunction associated structural alterations in CSVD. Results: 1. 51 patients were included in CSVD group and 37 in control group. After adjustment for gender, age, hypertension, stroke, BMI and apnea-hypopnea index(AHI), CSVD was independently associated to oxygen desaturation index (P=0.039).After adjusting age, gender, hypertension, stroke, AHI, and periodic limb movement index during sleep, significant difference of the standard deviation of normal-to-normal intervals(SDNN) during sleep period existed (P=0.030).The ratio of patients with reverse dipping patterns was higher in CSVD group after correcting age, gender, stroke, use of antihypertensive drugs, AHI and BP levels at the same periods. But no statistical differences in all BPV parameters were determined between two groups. 2. 19 CSVD patients and 16 community elders were finally included for VBM analysis. After adjustment for age, gender and AHI, grey matter atrophy in certain brain regions were more significant in CSVD group, especially in the right inferior orbitofrontal gyrus, superior medial frontal gyrus, insula, medial cingulate and bilateral medial temporal gyrus. Conclusion: CSVD patients have autonomic dysfunction which may be related with grey matter atrophy in part of autonomic network associated brain regions.

Published
2020

18. Epigallocatechin gallate preserves endothelial function by reducing the endogenous nitric oxide synthase inhibitor level

Author

Tang, Wei-Jun, Hu, Chang-Ping, Chen, Mei-Fang, Deng, Pan-Yue, and Li, Yuan-Jian

Subjects
Tumor necrosis factor -- Research, Nitric oxide -- Research, Low density lipoproteins -- Research, Biological sciences, Research
Abstract

Abstract: Asymmetric dimethylarginine (ADMA), the endogenous nitric oxide synthase inhibitor, is thought to be a key factor contributing to endothelial dysfunction. Tea catechins can cause an endothelium-dependent vasorelaxation. The present [...]

Published
2006

28. Gene mutation profiling of primary glioblastoma through multiple tumor biopsy guided by 1H-magnetic resonance spectroscopy

Author

Tang, Chao, Guo, Jun, Chen, Hong, Yao, Cheng-Jun, Zhuang, Dong-Xiao, Wang, Yin, Tang, Wei-Jun, Ren, Guang, Yao, Yu, Wu, Jin-Song, Mao, Ying, and Zhou, Liang-Fu

Subjects
Adult, Image-Guided Biopsy, Male, Aspartic Acid, Adolescent, Brain Neoplasms, Gene Expression Profiling, Proton Magnetic Resonance Spectroscopy, DNA Mutational Analysis, Mutation, Missense, Middle Aged, Magnetic Resonance Imaging, Choline, Young Adult, Phenotype, Codon, Nonsense, Biomarkers, Tumor, Humans, Original Article, Female, Genetic Predisposition to Disease, Neoplasm Grading, Glioblastoma
Abstract

Genetic mutation has served as the biomarkers for the diagnosis and treatment of glioblastoma multiforme (GBM). However, intra-tumor heterogeneity may interfere with personalized treatment strategies based on mutation analysis. This study aimed to characterize somatic mutation profiling of GBM. We collected 33 samples from 7 patients with the primary GBM associated with different Choline (Cho) to N-acetylaspartate (NAA) index (CNI) through the frameless proton magnetic resonance spectroscopy (1H-MRS) guided biopsies and investigated multiple somatic mutations profi ling using the AmpliSeq cancer hotspot panel V2. We identifi ed 53 missense or nonsense mutations in 27 genes including some novel mutations such as APC and IDH2. The mutations in EGFR, TP53, PTEN, PIK3CA genes were presented with different frequency and the majority of the mutated gene was only shared by 1-2 samples from one patient. Moreover, we found the association of CNI with histological grade, but there was no signifi cant change of CNI in the presence of TP53, EGFR and PTEN mutations. These data suggest that gene mutations constitute a heterogeneous marker for primary GBM which may be independent of intra-tumor morphological phenotypes of GBM; therefore, gene mutation markers could not be determined from a small number of needle biopsies or only confi ned to the high-grade region.

Published
2015

29. EGb761 improves the cognitive function of elderly db/db−/− diabetic mice by regulating the beclin-1 and NF-κB signaling pathways.

Author

Guan, Zhu-Fei, Zhang, Xiao-Ming, Tao, Ying-Hong, Zhang, Yu, Huang, Yan-Yan, Chen, Gang, Tang, Wei-Jun, Ji, Gang, Guo, Qi-Lin, Liu, Ming, Zhang, Qian, Wang, Na-Na, Yu, Zhong-Yu, Hao-Yang, Wu, Guo-Feng, Tang, Zhou-Ping, Du, Zun-Guo, Shang, Xi-Liang, Liu, Ying-Chao, and Mei, Guang-Hai

Subjects
NF-kappa B, PLANT extracts, CELLULAR signal transduction, COGNITION disorders, LABORATORY mice
Abstract

To assess whether EGb761 could protect elderly diabetic mice with cognitive disorders and explore the role of beclin-1-mediated autophagy in these protective effects. Two-month-old male db/db−/− mice and wild-type C57/BL6 mice were randomly divided into six groups: db/db−/− control, db/db−/− 50 mg, db/db−/− 100 mg, wild-type (WT) control, WT 50 mg, and WT 100 mg. EGb761 (50 mg/kg or 100 mg/kg of bodyweight) was given by gavage once a day for 1 month from the age of 6 months. Y-maze and social choice tests were performed at 8th months. The blood pressure was measured. The imaging changes in the brain were measured using magnetic resonance imaging (MRI). The expression and distribution of beclin-1, LC3, and NF-κB were detected using immunohistochemistry staining and western blotting. Ultrastructure alterations in the hippocampus were observed using transmission electron microscopy. Compared with WT mice, the learning ability, memory and overall cognitive function of db/db−/− mice decreased (P < 0.05), and EGb761 could significantly improve the learning and memory function of db/db−/− mice (P < 0.05). EGb761 significantly improved systolic blood pressure in db/db−/− mice (P < 0.01). In addition, fMRI-bold showed a decline in the hippocampus of mice in the db/db−/− group compared with WT. EGb761 could improve these above changes. Immunohistochemistry staining and western blotting confirmed that EGb761 significantly increased beclin-1 and reduced LC3-II/I levels in the brains of db/db−/− mice (P < 0.05). NF-κB levels were obviously higher in the db/db−/− group than that in the WT group, and EGb761 significantly reduced NF-κB levels in db/db−/− mice (P < 0.05). There was a trend of increased autophagosomes in db/db−/− mice, but EGb761 did not change obviously the number of autophagosomes. Compared with normal aged WT mice, aging db/db−/− mice had more common complications of cerebral small vessel disease and cognitive dysfunction. EGb761 could significantly improve the cognitive function of aging db/db−/− mice via a mechanism that may involve the regulation of beclin-1, LC3, and NF-κB. [ABSTRACT FROM AUTHOR]

Published
2018
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31. Process modeling and performance evaluation for re-configurable enterprise application system

Author

Tang Wei-jun and Zhang Mao-qing

Subjects
Process modeling, business.industry, Artifact-centric business process model, Business process, Computer science, Enterprise integration, Applications of UML, Integrated enterprise modeling, Petri net, Business process modeling, Business Process Model and Notation, Unified Modeling Language, Stochastic Petri net, Systems engineering, Software engineering, business, computer, computer.programming_language
Abstract

A framework for enterprise application system was proposed to reconfigure system's business process effectively by using method of separating process logical and business logical And then, UML/GSPN (generalized stochastic Petri nets) integrated modeling approach was adopted in the framework, it include System's process modeling in UML and performance evaluation in GSPN technology. An example of sales order process in enterprise application system was given to illustrate the validity of the approach. The result show that the performance evaluation method is capable of providing a basic quantitative analysis means in reconfiguration of system's business process.

Published
2011

32. Recurrent gain-of-function USP8 mutations in Cushing's disease

Author

Ma, Zeng-Yi, primary, Song, Zhi-Jian, additional, Chen, Jian-Hua, additional, Wang, Yong-Fei, additional, Li, Shi-Qi, additional, Zhou, Liang-Fu, additional, Mao, Ying, additional, Li, Yi-Ming, additional, Hu, Rong-Gui, additional, Zhang, Zhao-Yun, additional, Ye, Hong-Ying, additional, Shen, Ming, additional, Shou, Xue-Fei, additional, Li, Zhi-Qiang, additional, Peng, Hong, additional, Wang, Qing-Zhong, additional, Zhou, Dai-Zhan, additional, Qin, Xiao-Lan, additional, Ji, Jue, additional, Zheng, Jie, additional, Chen, Hong, additional, Wang, Yin, additional, Geng, Dao-Ying, additional, Tang, Wei-Jun, additional, Fu, Chao-Wei, additional, Shi, Zhi-Feng, additional, Zhang, Yi-Chao, additional, Ye, Zhao, additional, He, Wen-Qiang, additional, Zhang, Qi-Lin, additional, Tang, Qi-Sheng, additional, Xie, Rong, additional, Shen, Jia-Wei, additional, Wen, Zu-Jia, additional, Zhou, Juan, additional, Wang, Tao, additional, Huang, Shan, additional, Qiu, Hui-Jia, additional, Qiao, Ni-Dan, additional, Zhang, Yi, additional, Pan, Li, additional, Bao, Wei-Min, additional, Liu, Ying-Chao, additional, Huang, Chuan-Xin, additional, Shi, Yong-Yong, additional, and Zhao, Yao, additional

Published
2015
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33. THE DISTRIBUTION OF ABUTMENT PRESSURE ON THE INTERFACE BASED ON COAL-SEAM THICKNESS CHANGE AND ITS SUPPORT TYPE CHOICE.

Author

CHANG QING-LIANG, TANG WEI-JUN, SUN XI-KUI, WU FENG-FENG, and ZHOU HUA-QIANG

Subjects
*COALBED methane, *BRIDGE abutments, *SIMULATION methods & models, *COAL mining
Abstract

The distribution pattern and magnitude of abutment pressure along the working face did have a fundamental impact both on the stability of face wall and on the rational calculation of the supporting resistance. Taken the particular occurrence condition of variable thickness coal seam of Daizhuang mine in Shangdong Zibo Mining Group as the background, the distribution pattern and magnitude of the tendency of the abutment pressure on the working face has been analyzed in this thesis with the methods of theoretical analysis, numerical simulations and experimental measures. In this study the expression of abutment pressure has been established and it also shows that the variety of coal-seam thickness has led to the uneven distribution of abutment pressure. It also demonstrates while the working face is advancing, the strength of abutment pressure has been increased and its difference of stress distribution on both sides of the interface based on coal-seam thickness change has grown rapidly. This tells us the abutment pressure in the area of smaller thickness coal-seam is obviously greater than the one in the area of bigger thickness coal-seam. By the rational choice of two sets of support on working face, the safety of recovery requirements and support on the working face has been guaranteed. [ABSTRACT FROM AUTHOR]

Published
2016

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